4-Aminoantipyrine

For research use only.

Catalog No.S4509 Synonyms: Ampyrone, NSC 60242, Metapirazone, Solnapyrin-A, Solvapyrin-A, Minoazophene, Aminoazophene, Aminoantipyrin

4-Aminoantipyrine Chemical Structure

CAS No. 83-07-8

4-Aminoantipyrine(Ampyrone) is a metabolite of aminopyrine with analgesic, anti-inflammatory, and antipyretic properties. It is used as a reagent for biochemical reactions producing peroxides or phenols.

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Biological Activity

Description 4-Aminoantipyrine(Ampyrone) is a metabolite of aminopyrine with analgesic, anti-inflammatory, and antipyretic properties. It is used as a reagent for biochemical reactions producing peroxides or phenols.
In vitro

The level of glutathione(GSH) in single erythrocytes is impacted slightly at low AAP(4-aminoantipyrine) concentrations probably due to the protection of glutathione reductase. When AAP concentration further increases, AAP has a significant influence on GSH[2].

In vivo 4-aminoantipyrine (4-AA) is not genotoxic and mutagenic in vivo, it can interfere with DNA damaging agents biological activities and may reduce the effectiveness of DNA damage-based chemotherapy[3].

Protocol

Cell Research:

[2]

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  • Cell lines: Human erythrocytes
  • Concentrations: 1 × 10−6 mol/L to 1 × 10−3 mol/L
  • Incubation Time: 2 h
  • Method:

    Erythrocytes in PBS are incubated for 2 h at ambient temperature (without mixing) with AAP in concentrations from 1 × 10−6 mol/L to 1 × 10−3 mol/L. Sample of erythrocytes without AAP is used as control. After the exposure of AAP, erythrocytes are washed with borate buffer (pH 9.0) 2 times by centrifuging and determined for GSH.


    (Only for Reference)
Animal Research:

[1]

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  • Animal Models: Male Wistar rats
  • Dosages: 240 µmol/kg
  • Administration: iv(caudal vein)
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 40 mg/mL (196.81 mM)
Water 40 mg/mL (196.81 mM)
Ethanol 40 mg/mL (196.81 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 203.24
Formula

C11H13N3O

CAS No. 83-07-8
Storage powder
in solvent
Synonyms Ampyrone, NSC 60242, Metapirazone, Solnapyrin-A, Solvapyrin-A, Minoazophene, Aminoazophene, Aminoantipyrin
Smiles CC1=C(C(=O)N(N1C)C2=CC=CC=C2)N

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID