Home PI3K/Akt/mTOR Akt inhibitor - mTOR inhibitor - ROS activator - Autophagy activator ABTL-0812 For research use only.

ABTL-0812

Synonyms: α-Hydroxylinoleic acid

ABTL0812 (α-Hydroxylinoleic acid, LP-10218, SCLN-0812) inhibits Akt/mTOR axis by inducing the overexpression of TRIB3 and activating autophagy in lung squamous carcinoma cell lines. ABTL0812 also induces AMPK activation and ROS accumulation.

ABTL-0812 Chemical Structure

ABTL-0812 Chemical Structure

CAS: 57818-44-7

Purity & Quality Control

Batch: S961101 Purity: 99.33%
99.33

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Signaling Pathway

Akt Signaling Pathways

Akt Signaling Pathway

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Biological Activity

Description ABTL0812 (α-Hydroxylinoleic acid, LP-10218, SCLN-0812) inhibits Akt/mTOR axis by inducing the overexpression of TRIB3 and activating autophagy in lung squamous carcinoma cell lines. ABTL0812 also induces AMPK activation and ROS accumulation.
Targets
Akt [1] mTOR [1]
In vitro
In vitro

ABTL0812 inhibits Akt/mTOR axis by inducing the overexpression of TRIB3 and activating autophagy in lung squamous carcinoma cell lines. Furthermore, treatment with ABTL0812 also induces AMPK activation and ROS accumulation. Moreover, combination of ABTL0812 with chemotherapy markedly increases the therapeutic effect of chemotherapy without increasing toxicity. Combination of ABTL0812 and chemotherapy induces nonapoptotic cell death mediated by TRIB3 activation and autophagy induction.[1]
Cell Research Cell lines Human adenocarcinoma cell lines (A549, NCI-H1975), squamous-cell carcinoma (NCI-H520, NCI-H157)
Concentrations 0–200 μM
Incubation Time 72 h
Method

Briefly, for docetaxel studies, subconfluent cultures of adenocarcinoma lung cancer cells are incubated for 72 hr in the presence of an increasing concentration of ABTL0812 (0–200 μM), docetaxel (0–100 μM) or the combination of increasing doses of docetaxel with ABTL0812 20 μM. For paclitaxel studies, subconfluent cultures of adenocarcinoma and squamous lung cancer cell lines are incubated for 48 hr in the presence of an increasing concentration of paclitaxel (0–1 μM) or the combination of increasing doses of paclitaxel with sub-IC50 concentrations of ABTL0812 (5–30 μM).
In Vivo
In vivo

ABTL0812 enhances carboplatin and paclitaxel antitumor activity both in adenocarcinomas and squamous lung xenografts.[1]
Animal Research Animal Models 5-week-old female athymic nude Foxn 1nu nu/nu mice
Dosages 30 mg/kg, 120 mg/kg
Administration Oral gavage
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02201823 Completed
Cancer
Ability Pharmaceuticals SL|Hospital Clinic of Barcelona|Institut Català d''Oncologia
 February 2014 Phase 1

Chemical Information & Solubility

Molecular Weight 296.44 Formula

C18H32O3
CAS No. 57818-44-7 SDF --
Density 1.0 g/mL
Smiles CCCCCC=CCC=CCCCCCCC(C(=O)O)O
Storage (From the date of receipt) 2 years -20°C liquid

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