Home Neuronal Signaling AChR inhibitor - Dopamine Receptor inhibitor Amfebutamone (Bupropion) HCl For research use only.

Amfebutamone (Bupropion) HCl

Synonyms: Wellbutrin

Amfebutamone (Bupropion) HCl(Wellbutrin) is a selective norepinephrine-dopamine reuptake inhibitor with IC50 of 6.5 and 3.4 μM for the reuptake of dopamine and norepinephrine, respectively.

Amfebutamone (Bupropion) HCl Chemical Structure

Amfebutamone (Bupropion) HCl Chemical Structure

CAS: 31677-93-7

Selleck's Amfebutamone (Bupropion) HCl has been cited by 3 publications

Purity & Quality Control

Batch: Purity: 99.98%
99.98

Amfebutamone (Bupropion) HCl Related Products

Signaling Pathway

AChR Signaling Pathways

AChR Signaling Pathway

Choose Selective AChR Inhibitors

Biological Activity

Description Amfebutamone (Bupropion) HCl(Wellbutrin) is a selective norepinephrine-dopamine reuptake inhibitor with IC50 of 6.5 and 3.4 μM for the reuptake of dopamine and norepinephrine, respectively.
Targets
Dopamine receptor [1] AChR [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04902625 Recruiting
Obesity Morbid|Bariatric Surgery Candidate|Medication Persistence
Zuyderland Medisch Centrum|Nederlandse Obesitas Kliniek
 March 21 2023 Phase 4
NCT04718740 Completed
Recurrent Ovarian Cancer
Jiangsu HengRui Medicine Co. Ltd.
 June 25 2021 Phase 1

Chemical Information & Solubility

Molecular Weight 276.2 Formula

C13H18ClNO.HCl
CAS No. 31677-93-7 SDF Download Amfebutamone (Bupropion) HCl SDF
Smiles CC(C(=O)C1=CC(=CC=C1)Cl)NC(C)(C)C.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 8 mg/mL ( (28.96 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
Batch:

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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