Amcasertib (BBI503)

For research use only.

Catalog No.S8572

1 publication

Amcasertib (BBI503) Chemical Structure

Molecular Weight(MW): 539.69

Amcasertib (BBI503), a first-in-class cancer stemness kinase inhibitor, is claimed to inhibit Nanog and other CSC pathways by targeting kinases with potential anticancer activity.

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Selleck's Amcasertib (BBI503) has been cited by 1 publication

Purity & Quality Control

Choose Selective Stemness kinase Inhibitors

Biological Activity

Description Amcasertib (BBI503), a first-in-class cancer stemness kinase inhibitor, is claimed to inhibit Nanog and other CSC pathways by targeting kinases with potential anticancer activity.
Targets
Nanog [1]
()
In vitro

BBI-503 is orally-administered compound, which is designed to target CSC pathways in multiple tumour types[1].

In vivo BBI503 inhibits Nanog and other cancer stem cell pathways by targeting kinases, and shows encouraging early signs of anti-cancer activity for patients with advanced colorectal cancer[1].

Protocol

Solubility (25°C)

In vitro DMSO 14 mg/mL (25.94 mM)
Ethanol 1 mg/mL (1.85 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 539.69
Formula

C31H33N5O2S

CAS No. 1129403-56-0
Storage powder
in solvent
Synonyms N/A
Smiles CCN(CC)CCNC(=O)C1=C(NC(=C1C)C=C2C3=C(C=CC(=C3)C4=CSC(=N4)C5=CC=CC=C5)NC2=O)C

In vivo Formulation Calculator (Clear solution)

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Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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  • Computed Result

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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02232620 Terminated Drug: BBI503 Gastrointestinal Stromal Tumors Sumitomo Dainippon Pharma Oncology Inc March 13 2017 Phase 2
NCT02232646 Withdrawn Drug: BBI503 Urologic Malignancies|Renal Cell Carcinoma|Urothelial Carcinoma Sumitomo Dainippon Pharma Oncology Inc January 2017 Phase 2
NCT02432326 Completed Drug: BBI608|Drug: BBI503 Cancer|Advanced Solid Tumors Sumitomo Dainippon Pharma Oncology Inc April 2015 Phase 1
NCT02354898 Completed Drug: BBI503|Drug: Sorafenib Advanced Solid Tumors|Hepatocellular Carcinoma Sumitomo Dainippon Pharma Co. Ltd. March 2015 Phase 1
NCT02232633 Active not recruiting Drug: BBI503 Hepatocellular Carcinoma|Cholangiocarcinoma Sumitomo Dainippon Pharma Oncology Inc February 2015 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID