Molecular Weight(MW): 539.69
Amcasertib (BBI503), a first-in-class cancer stemness kinase inhibitor, is claimed to inhibit Nanog and other CSC pathways by targeting kinases with potential anticancer activity.
Purity & Quality Control
Choose Selective Stemness kinase Inhibitors
|Description||Amcasertib (BBI503), a first-in-class cancer stemness kinase inhibitor, is claimed to inhibit Nanog and other CSC pathways by targeting kinases with potential anticancer activity.|
BBI-503 is orally-administered compound, which is designed to target CSC pathways in multiple tumour types.
|In vivo||BBI503 inhibits Nanog and other cancer stem cell pathways by targeting kinases, and shows encouraging early signs of anti-cancer activity for patients with advanced colorectal cancer.|
|In vitro||DMSO||14 mg/mL (25.94 mM)|
|Ethanol||1 mg/mL (1.85 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2
Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02232620||Terminated||Drug: BBI503||Gastrointestinal Stromal Tumors||Boston Biomedical Inc||March 13 2017||Phase 2|
|NCT02232646||Withdrawn||Drug: BBI503||Urologic Malignancies|Renal Cell Carcinoma|Urothelial Carcinoma||Boston Biomedical Inc||January 2017||Phase 2|
|NCT02432326||Active not recruiting||Drug: BBI608|Drug: BBI503||Cancer|Advanced Solid Tumors||Boston Biomedical Inc||April 2015||Phase 1|
|NCT02354898||Completed||Drug: BBI503|Drug: Sorafenib||Advanced Solid Tumors|Hepatocellular Carcinoma||Sumitomo Dainippon Pharma Co. Ltd.||March 2015||Phase 1|
|NCT02232633||Active not recruiting||Drug: BBI503||Hepatocellular Carcinoma|Cholangiocarcinoma||Boston Biomedical Inc||February 2015||Phase 2|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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