Aciclovir (BW 248U)

For research use only.

Catalog No.S1807 Synonyms: Acyclovir, Acycloguanosine, Zovirax, ACV, NSC 645011

10 publications

Aciclovir (BW 248U) Chemical Structure

CAS No. 59277-89-3

Acyclovir (BW 248U, Acyclovir, Acycloguanosine, Zovirax, ACV, NSC 645011) is a synthetic nucleoside analogue active against herpesviruses. Acyclovir induces cell cycle perturbation and apoptosis in Jurkat leukemia cells.

Selleck's Aciclovir (BW 248U) has been cited by 10 publications

1 Customer Review

  • (A) HONE1 and (B) HK1-EBV cells were treated with TPA (40 ng/ml) and SB (3 mM) for EBV induction. After 3 h, uninduced and induced HONE1 and HK1-EBV cells were treated with the vehicle control (0.006% DMSO) or indicated concentrations of berberine for 48 h. Subsequently, the culture medium was harvested for quantitative-PCR analysis with EBNA1 primers. Each sample was normalized to the amount of the GAPDH gene; *p<0.05, compared with the control group.

    Oncol Rep, 2017, 37(4):2109-2120. Aciclovir (BW 248U) purchased from Selleck.

Purity & Quality Control

Choose Selective Antiviral Inhibitors

Biological Activity

Description Acyclovir (BW 248U, Acyclovir, Acycloguanosine, Zovirax, ACV, NSC 645011) is a synthetic nucleoside analogue active against herpesviruses. Acyclovir induces cell cycle perturbation and apoptosis in Jurkat leukemia cells.
Targets
HSV [1]
In vitro

Acyclovir sensitivity of herpes simplex virus isolates is determined in a plaque-reduction assay in Vero cells. IC50 Values are consistently 2-3 fold lower in B2 compared with the H strain of Vero cells. HSV Type 2 strains are 2-10-fold less sensitive than Type 1 strains[2].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
BSC-1 cells MmHsSpVv[3Srb36gZZN{[Xl? MXzBcpRqfmm{YXygZYN1cX[rdImgc4YhfGinIHPvcZBwfW6mIIfhd{BmfmGudXH0[YQh[WejaX7zeEB1cGViSHXydIV{KHOrbYDs[Zghfmm{dYOgeJlx\S1zIHnuJGJUSy1zIHPlcIx{NCCLQ{WwQVIvPiEQvF2= NUHKdG1sOjlzM{OwNC=>
P3HR-1 cells MVjGeY5kfGmxbjDhd5NigQ>? NH3pPVhG\m[nY4TpeoUh[2:wY3XueJJifGmxbjDmc5IhfGinIHnubIljcXSrb36gc4YhTXC|dHXpck1D[XK{II\pdpV{KEWEVj3EUmEhe3mwdHjld4l{KGmwIHj1cYFvKGy7bYDoc4Jt[XO2b3nkJHA{UFJvMTDj[YxteyxiRVO1NF03Njd3IN88US=> M{nwN|EzPDB6N{K2
HFF cells MYnGeY5kfGmxbjDhd5NigQ>? MUjDc45k\W62cnH0bY9vKG[xcjDIV3YuOSCybHHxeYUhemWmdXP0bY9vKCiYUGKpJIJ6KDVyJTDpckBJTkZiY3XscJMtKEWFNUC9NU4yKM7:TR?= NFTO[5QyPDV6NEm1OC=>
HFF cells MkXSSpVv[3Srb36gZZN{[Xl? NIrMNY1KdmirYnn0c5J6KGOxbnPlcpRz[XSrb36gdoVyfWm{ZXSgeI8hemWmdXPlJGhUXi1zIHnu[JVk\WRiY4n0c5BifGixZ3XubYMh\W[oZXP0JEhEWEVrIHL5JFUxKCViaX6gTGZHKGOnbHzzMEBGSzVyPUKuNlIh|ryP M2XzRVE1PTh2OUW0
human embryonic lung cells MlTiSpVv[3Srb36gZZN{[Xl? NHq1WXRCdnSrdnnyZYwh[WO2aY\peJkhf2G|IH3lZZN2emWmIHHzJIVn\mWldHn2[UBkd26lZX70doF1cW:wIILldZVqemWmIITvJJJm\HWlZTDWZZJq[2WubHGgXo9{fGW{II\pdpV{KCiRS1GpMYlv\HWlZXSgdIxieXWnIH\vdo1ifGmxbjDpckBpfW2jbjDlcYJzgW:waXOgcJVv\yClZXzsd{whTUN3ME2xMlEh|ryP NGO1dVQyOTV2OUS1Oy=>
HEL cells M1HlV2Z2dmO2aX;uJIF{e2G7 M2DuOGNwdXCxdX7kJJdieyC2ZYP0[YQh\m:{IHHueIkufmm{YXygZYN1cX[rdImgZYdicW6|dDDIV3YuOSiJKTDpckBJTUxiY3XscJMtKEWFNUC9NU4{KM7:TR?= NUDRToFvOTR4NEOzNlg>
HEL cell M4DIU2Z2dmO2aX;uJIF{e2G7 M2n3XWVn\mWldHn2[UBkd26lZX70doF1cW:wIILldZVqemWmIITvJIlvcGmkaYSgWJlzd3OrbnWgb4lv[XOnIDjUT{sqKF[jcnnj[Yxt[S2cb4P0[ZIhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjbZR6KGK7IEWwKUBqdiCRS1Ggd5Rz[WmwIFjFUEBk\WyuIHzpcoV{NCCHQ{WwQVQvPTNizszN M{O1[FEyPDl3NUi2
HSV-2 MS Vero cells NHz1SWpHfW6ldHnvckBie3OjeR?= NVyxO|FkUW6qaXLpeIlwdiCxZjD2bZJidCCleYTvdIF1cGmlIHXm[oVkfCCrbjDpcoZm[3SnZDDoeY1idiCob4Lld4tqdiCoaXLyc4Jt[XO2IHPlcIwhdW:wb3zhfYVzeyCxZjDIV3YuOiCPUzDW[ZJwKGOnbHzzJIJ6KDVyJTygSWM2OD14LkKg{txO NFHhR2IyOTV6NUS1Oy=>
HSV-1 E-377 Vero cells NF;lco9HfW6ldHnvckBie3OjeR?= MWLJcohq[mm2aX;uJI9nKHCuYYH1[UBnd3KvYYTpc44hcW5ibX;uc4xigWW{czDv[kBJW1ZvMTDFMVM4PyCYZYLvJINmdGy|IHL5JFUxLSxiRVO1NF01NjRizszN MoruNVE2QDV2NUe=
HSV-1 KOS Vero cells MYjGeY5kfGmxbjDhd5NigQ>? MoXtTY5pcWKrdHnvckBw\iCybHHxeYUh\m:{bXH0bY9vKGmwIH3vco9t[XmncoOgc4YhUFOYLUGgT29UKF[ncn:gZ4VtdHNiYomgOVAmNCCHQ{WwQVIvOiEQvF2= NXr1dYFmOTF3OEW0OVc>
HeLa cell MnqwSpVv[3Srb36gZZN{[Xl? NV3BOpM3SWKrbHn0fUB1dyCrbnjpZol1KGO7dH;wZZRpd2enbnnjbZR6KG:oIHjldpBmeyC|aX3wcIV5KHS7cHWgNUB3cXK3czCoS{khcW5iSHXMZUBk\WyuIHP1cJR2emVuIFnDOVA:OC5zOTFOwG0> NU\sdWQyOTF|NU[xNVA>
HEp-2 cells MUPGeY5kfGmxbjDhd5NigQ>? MUnNbY5qdXWvIHnubIljcXSxcomgZ49v[2WwdILheIlwdiClYYXzbY5oKDJ3JTDpcohq[mm2aX;uJI9nKGO7dH;wZZRpcWNiZX\m[YN1KGmwZIXj[YQh[nliSHXydIV{KHOrbYDs[Zghfmm{dYOtNUApUzl5OTmgbY4hUEWyLUKgZ4VtdHN? MoLqNlg1OjVyNh?=
HeLa cells MX3GeY5kfGmxbjDhd5NigQ>? NIn5O4RKdmirYnn0bY9vKG:oIFjTWk0yKESQQTDzfY51cGW|aYOgbY4hfmm{dYOtbY5n\WO2ZXSgTIVN[SClZXzsd{whUUN3ME2xMlkh|ryP Mo\HO|c2OjJyNh?=
human HFF cells M3T6W2Z2dmO2aX;uJIF{e2G7 Ml7wTY5pcWKrdH;yfUBkd26lZX70doF1cW:wIH;mJJRp\SCmcoXnJIFo[Wmwc4SgeIhmKGO7dH;wZZRpcWNiZX\m[YN1KG[xcjDFMVM4PyC|dILhbY4hd2ZiaHXydIV{KHOrbYDs[Zghfmm{dYOtNUApUFOYLUGpJIlvKGi3bXHuJGhHTiClZXzsd{whTUN3ME2wMlA1KM7:TR?= MWG4N|k1QTN|
human HFF cells NGLnZohHfW6ldHnvckBie3OjeR?= NV7FOZIyUW6qaXLpeI9zgSClb37j[Y51emG2aX;uJI9nKHSqZTDkdpVoKGGpYXnud5QhfGinIHP5eI9x[XSqaXOg[YZn\WO2IH\vdkBOWyC|dILhbY4hd2ZiaHXydIV{KHOrbYDs[Zghfmm{dYOtNkApUFOYLUKpJIlvKGi3bXHuJGhHTiClZXzsd{whTUN3ME2wMlA6KM7:TR?= MUK4N|k1QTN|
MRC-5 cells NFLGVFlHfW6ldHnvckBie3OjeR?= MYfBcpRqfmm{YXygZYN1cX[rdImgbY4heGyjcYXlJJJm\HWldHnvckBie3OjeTD3ZZMh\GW2ZYLtbY5m\CCjZ3HpcpN1KGincoDld{B{cW2ybHX4JJZqenW|IIT5dIUhOiBqSGPWMVIqKGmwIF3SR{02KGOnbHzzMEBKSzVyPUKuOUDPxE1? M2C5NFIyPTN{MEK=
human lung fibroblasts (MRC-5) NHvkVXNHfW6ldHnvckBie3OjeR?= NWn3[ZN7S2:vcH;1coQhf2G|IITld5Rm\CCob4KgZY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVzeGW|IGPpcZBt\XhidnnyeZMhXHmyZT2xLFE5OTh7KTDpckBpfW2jbjDseY5oKG[rYoLvZoxie3S|IDjNVmMuPSl? NIP3WHo{ODRyOUm4
Raji cells M1TTVGZ2dmO2aX;uJIF{e2G7 M2fhTGlvcGmkaYTvdpkh[2:wY3XueJJifGmxbjDv[kB1cGViZIL1[{Bi\2GrboP0JJRp\SCjboTp[4VvKHC{b3T1Z5Rqd25iYXfhbY5{fCCSM1jSMVEhe3S{YXnuJI9nKGWyc4TlbY4h[mG{cjD2bZJ2ey1{IDjFRnYqKGmwIGLhbokh[2WubIOsJGVEPTB;Mj65JO69VQ>? NY\CVIRRQDN7NEmzNy=>
Vero cells NFHSXYlHfW6ldHnvckBie3OjeR?= M3XzT2lvcGmkaYTvdpkh[WO2aY\peJkh[WejaX7zeEBp\XKyZYOgd4lueGyneDD2bZJ2eyC2eYDlJFIhMEiVVjCyLUB{fHKjaX6gNVg3KGmwIG\ldo8h[2WubIOsJGlEPTB;MT63JO69VQ>? Mn[1PFU4Pjl{Mh?=
BSC-1 cells NYDwO|dMTnWwY4Tpc44h[XO|YYm= NX7lSHhSTW[oZXP0bZZmKGOxbnPlcpRz[XSrb36gdoVyfWm{ZXSgeI8hcW6qaXLpeEBp\XKyZYOgd4lueGyneDD2bZJ2eyBzIHnuJGJUSy1zIHPlcIx{KGmwIFXMTXNCNCCHQ{WwQVEvPSEQvF2= Mn;VNVU3OzRyMEO=
HFF cells MkfmSpVv[3Srb36gZZN{[Xl? NV7n[G1sTW[oZXP0bZZmKGOxbnPlcpRz[XSrb36gdoVyfWm{ZXSgeI8hcW6qaXLpeEB3[XKrY3XscIEhgm:|dHXyJJZqenW|IILldIxq[2G2aX;uJIlvKEiIRjDj[YxteyxiRVO1NF0yNjZizszN NV\JRopnOTV4M{SwNFM>
HFF cells M13nSGZ2dmO2aX;uJIF{e2G7 MU\F[oZm[3SrdnWgZ49v[2WwdILheIlwdiC{ZYH1bZJm\CC2bzDpcohq[mm2IHjldpBmeyC|aX3wcIV5KH[rcoXzJFEhcW5iSF\GJINmdGy|IHnuJIN6fG:yYYTobYMh\W[oZXP0JEhEWEVrIHHzd4F6NCCHQ{WwQVAvQSEQvF2= M2L6blE2PjN2MECz
Daudi cells NYqxUYxDTnWwY4Tpc44h[XO|YYm= NHn3SGZKdmirYnn0bY9vKG:oIFXCWkBz\XCuaXPheIlwdiCrbjDEZZVlcSClZXzsd{BjgSC4aYLhcEBk[XC|aXSgZY51cWenbj3FUGlUSSxiRVO1NF0xNjN|IN88US=> NXrISm1uOTdyMES3NlY>
african green monkey Vero cells NXPMZXFNTnWwY4Tpc44h[XO|YYm= MVO0PEBp M33xUmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhUXjJic4TyZYlvKDN|MzDpcoZm[3SnZDDpckBi\nKrY3HuJIdz\WWwIH3vcotmgSCYZYLvJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiY4n0c5BifGirYzDl[oZm[3RiYX\0[ZIhPDhiaILzJIJ6KHCuYYH1[UBz\WS3Y4Tpc44h[XO|YYmsJGVEPTB;MT64O{DPxE1? M2rWXFIzPzB2OEmw
WI-38 cell M4\PN2Z2dmO2aX;uJIF{e2G7 NF7hNnFCdnSrII\pdoFtKGGldHn2bZR6KGGpYXnud5QhXlqYKIDwcIxiKHO2cnHpckkhcW5iV1mtN|gh[2WubDDtc45wdGG7ZYLzMEBKTDVyPUSg{txO MXSxN|E3QTZ4
HEL cells Mn\YSpVv[3Srb36gZZN{[Xl? NEDCbYg1KGSjeYO= MYHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIV3YyKEuRUzDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqb3flcolkcXS7IHHmeIVzKDRiZHH5d{whTUN3ME2wMlIh|ryP MXeyNlQ2QTh5Nh?=
HEL cells NVeyeIVUTnWwY4Tpc44h[XO|YYm= MWXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIV3YyKEuRUzDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXOg[YZn\WO2LDDFR|UxRTBwMUSg{txO MnHXNlMxQTlyOUe=
African green monkey Vero 76 cells MWnDfZRwfG:6aXPpeJkh[XO|YYm= M3vlVlQ5NTl4IHi= MVnDfZRwfG:6aXPpeJkh[WejaX7zeEBC\nKrY3HuJIdz\WWwIH3vcotmgSCYZYLvJFc3KGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IES4JJRwKDl4IHjyd{BjgSClconzeIFtKH[rb3zleEB{fGGrbnnu[{whS0N3ME2xN{DPxE1? Mn\1NlYyOTl7OUK=

... Click to View More Cell Line Experimental Data

In vivo low-dose oral acyclovir may be effective in the prevention of HSV infection during OKT3 treatment of seropositive patients. Continuation of acyclovir prophylaxis for two to four weeks following the conclusion of OKT3 therapy may prevent occurrence of delayed infections[3].

Protocol

Solubility (25°C)

In vitro DMSO 45 mg/mL (199.82 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 225.2
Formula

C8H11N5O3

CAS No. 59277-89-3
Storage powder
in solvent
Synonyms Acyclovir, Acycloguanosine, Zovirax, ACV, NSC 645011
Smiles C1=NC2=C(N1COCCO)N=C(NC2=O)N

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04448392 Not yet recruiting Drug: Valacyclovir Neonatal Herpes Simplex Infection University of Alabama at Birmingham July 2021 Phase 1
NCT02997982 Completed Drug: Valaciclovir 500Mg Tablet Alzheimer Disease|Mild Cognitive Impairment|Herpes Simplex Hugo Lovheim|Umeå University December 2016 Phase 2
NCT02879630 Recruiting -- Obesity West Virginia University August 2016 --
NCT02152358 Unknown status Drug: Aciclovir|Drug: Ganciclovir|Drug: Placebo Viral Pneumonia Assistance Publique Hopitaux De Marseille March 2014 Phase 4

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID