Home Neuronal Signaling GABA Receptor modulator AZD7325

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AZD7325 GABA Receptor modulator

Cat.No.S0164

AZD7325 is a potent and orally active partial selective Positive allosteric modulator (PAM) of GABAAα2 and Aα3 receptor with Ki=0.3 and 1.3 nM, respectively, and has less antagonistic efficacy at the Aα1 and Aα5 receptor subtypes.
AZD7325 GABA Receptor modulator Chemical Structure

Chemical Structure

Molecular Weight: 354.38

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Quality Control

Batch: S016401 DMSO]71 mg/mL]false]Ethanol]71 mg/mL]false]Water]Insoluble]false Purity: 99.95%
99.95

Solubility

In vitro
Batch:

DMSO : 71 mg/mL (200.34 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 71 mg/mL

Water : Insoluble

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Chemical Information, Storage & Stability

Molecular Weight 354.38 Formula

C19H19FN4O2

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 942437-37-8 -- Storage of Stock Solutions

Synonyms N/A Smiles CCCNC(=O)C1=NN=C2C(=C1N)C=CC=C2C3=C(C=CC=C3F)OC

Mechanism of Action

Targets/IC50/Ki
Aα1
Aα5 receptor
GABAAα2
0.3 nM(Ki)
Aα3
1.3 nM(Ki)
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02530580 Completed
Healthy
University College London
 February 2016 Phase 1
NCT02135198 Completed
Healthy
University College London
 September 2014 Phase 1
NCT00940641 Suspended
Absorption|Distribution|Metabolism|Excretion
AstraZeneca
 August 2009 Phase 1
NCT00945425 Terminated
Healthy
AstraZeneca
 July 2009 Phase 1
NCT00901290 Suspended
Pharmacokinetics
AstraZeneca
 May 2009 Phase 1
NCT00769899 Completed
Healthy Volunteer
AstraZeneca
 October 2008 Phase 1

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