Abacavir sulfate

Catalog No.S3165 Synonyms: 1592U89

For research use only.

Abacavir (1592U89) is a commonly used nucleoside analogue with potent antiviral activity against HIV-1.

Abacavir sulfate Chemical Structure

CAS No. 188062-50-2

Selleck's Abacavir sulfate has been cited by 4 Publications

Purity & Quality Control

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Biological Activity

Description Abacavir (1592U89) is a commonly used nucleoside analogue with potent antiviral activity against HIV-1.
Targets
HIV-1 reverse-transcriptase [1]
In vitro

Abacavir is an analog of guanosine (a purine). Its target is the viral reverse transcriptase enzyme.

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 335.35
Formula

C14H18N6O.1/2 H2SO4

CAS No. 188062-50-2
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1CC1NC2=C3C(=NC(=N2)N)N(C=N3)C4CC(C=C4)CO.C1CC1NC2=C3C(=NC(=N2)N)N(C=N3)C4CC(C=C4)CO.OS(=O)(=O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04133012 Recruiting Other: Samplings HIV-1 Infection ANRS Emerging Infectious Diseases|ViiV Healthcare February 10 2020 Not Applicable
NCT02708342 Completed -- HIV Ospedale San Raffaele|Merck Sharp & Dohme LLC April 2016 --

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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