Home Microbiology Reverse Transcriptase inhibitor Abacavir sulfate

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Abacavir sulfate Reverse Transcriptase inhibitor

Cat.No.S3165

Abacavir (1592U89) is a commonly used nucleoside analogue with potent antiviral activity against HIV-1.
Abacavir sulfate Reverse Transcriptase inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 335.35

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Quality Control

Batch: Purity: 99.85%
99.85

Solubility

In vitro
Batch:

Water : 67 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

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In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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%
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 335.35 Formula

C14H18N6O.1/2 H2SO4

 Storage (From the date of receipt)
CAS No. 188062-50-2 Download SDF Storage of Stock Solutions

Synonyms 1592U89 SMILES C1CC1NC2=C3C(=NC(=N2)N)N(C=N3)C4CC(C=C4)CO.C1CC1NC2=C3C(=NC(=N2)N)N(C=N3)C4CC(C=C4)CO.OS(=O)(=O)O

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

Targets/IC50/Ki
HIV-1 reverse-transcriptase
In vitro
Abacavir is an analog of guanosine (a purine). Its target is the viral reverse transcriptase enzyme.
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-08-28)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT07792096 NOT_YET_RECRUITING
HIV Infection
University College, London
 2026-11 PHASE3
NCT06428045 RECRUITING
High Grade Glioma
University of Miami
 2025-04-15 PHASE1
NCT06356740 NOT_YET_RECRUITING
Systemic Lupus Erythematosus
Hospices Civils de Lyon
 2024-09-01 PHASE2
NCT05193994 TERMINATED
Amyotrophic Lateral Sclerosis
Macquarie University, Australia
 2022-02-24 PHASE3
NCT06658977 TERMINATED
Amyotrophic Lateral Sclerosis; ALS
Macquarie University, Australia
 2024-11-15 PHASE3
NCT04731103 COMPLETED
Aicardi-Goutières Syndrome
University of Edinburgh
 2022-08-24 PHASE2

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