Agomelatine (S20098)

For research use only.

Catalog No.S1243

3 publications

Agomelatine (S20098) Chemical Structure

CAS No. 138112-76-2

Agomelatine (S20098) is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor.

Selleck's Agomelatine (S20098) has been cited by 3 publications

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Biological Activity

Description Agomelatine (S20098) is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor.
5-HT2C [1]
In vitro

Agomelatine completely normalizes stress-affected cell survival and partly reverses reduced doublecortin expression in the hippocampus of rats subjected to chronic footshock stress. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEK 293 NUDoWotXTnWwY4Tpc44h[XO|YYm= NVrmUGk5SmmwZHnu[{Bi\m[rbnn0fUBnd3JiaIXtZY4hVWWuYYTvcolvKHKnY3XweI9zKHS7cHWgNWEhe3SjYnz5JJRz[W6|ZnXjeIVlKGmwIHj1cYFvKGWvYoL5c45q[yCtaXTu[Zkh[2WubIOgLGhGUyB{OUOpJJV{cW6pIEKtX|EzPUmfaX;kc41mdGG2b37pckBieyC{YXTpc4xq\2GwZDygT4k:PmVvMEWg{txO NEXvVlcyOjZ2NkCyNi=>
CHO cells NV74PFNiTnWwY4Tpc44h[XO|YYm= M3vpOFEzOCCvaX7z MUPEbZNxdGGlZX3lcpQhd2ZiW{GyOWlecW:mb33lcIF1d26rbjDmc5JuKGi3bXHuJG1VOSC{ZXPldJRweiCneIDy[ZN{\WRiaX6gR2hQKGOnbHzzJIFnfGW{IEGyNEBucW6|LDDLbV0xNjFibl2= MlLrNlI{ODF{MUS=
CHO-Galpha16 cells NYHScYVbTnWwY4Tpc44h[XO|YYm= NX\QRWNWOjBibXnudy=> NVf0SYxvSmmwZHnu[{Bi\m[rbnn0fUB1dyC{YYSgUXQyKHKnY3XweI9zKGW6cILld5Nm\CCrbjDDTG8uT2GucHjhNVYh[2WubIOgZZN{\XO|ZXSgZZMhS2F{KzDtc4JqdGm8YYTpc44h[W[2ZYKgNlAhdWmwczDifUBHVEmSUjDhd5NigSxiRVO1NF0zNjFibl2= MmrNNlEzOzd4NES=

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In vivo Agomelatine is effective in reversing the transgenic mouse behavioural changes noted in the Porsolt forced swim test as well as in the elevated plus maze. Agomelatine also markedly accelerates readjustment of circadian cycles of temperature and activity following an induced phase shift. [2] Agomelatine enhances cell proliferation and neurogenesis in the ventral hippocampus (VH) of adult rats, a region pertinent to mood disorders. Agomelatine increases the ratio of mature vs immature neurons and enhances neurite outgrowth of granular cells in adult rats, suggesting an acceleration of maturation. Agomelatine also activates several cellular signals (extracellular signal-regulated kinase1/2, protein kinase B, and glycogen synthase kinase 3beta) known to be modulated by antidepressants and implicated in the control of proliferation/survival. [3] Agomelatine enhances the time devoted to active social interaction in unfamiliar pairs of rats exposed to a novel environment. [4] Agomelatine increases cell proliferation and neurogenesis in the ventral dentate gyrus of rats, a region notably implicated in response to emotion, which is consistent with the antidepressant-anxiolytic properties of Agomelatine. Agomelatine increases survival of newly formed neurons in the entire dentate gyrus of rats. [5]


Solubility (25°C)

In vitro DMSO 48 mg/mL (197.28 mM)
Water Insoluble
Ethanol ''48 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 243.3


CAS No. 138112-76-2
Storage powder
in solvent
Synonyms N/A
Smiles CC(=O)NCCC1=CC=CC2=C1C=C(C=C2)OC

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03977441 Unknown status Drug: Agomelatine or PIacebo Parkinson Disease|Depression|Sleep Disorders|Circadian Rhythm Disorders Second Affiliated Hospital of Soochow University July 2019 Phase 4
NCT00463242 Completed Drug: Agomelatine|Drug: paroxetine|Drug: placebo Major Depressive Disorder Novartis March 2007 Phase 3

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5-HT Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID