Home Metabolism Peroxidases inhibitor 4-Aminobenzohydrazide For research use only.

4-Aminobenzohydrazide

Synonyms: 4-Aminobenzhydrazide, 4-aminobenzoic acid hydrazide, 4-ABAH, Myeloperoxidase Inhibitor I, NSC 640

4-Aminobenzohydrazide (4-Aminobenzhydrazide, 4-aminobenzoic acid hydrazide, 4-ABAH, Myeloperoxidase Inhibitor I, NSC 640) is an inhibitor of MPO (Myeloperoxidase) enzyme that enhances iNOS induction in MPO-positive cells, but not in MPO-KO cells.

4-Aminobenzohydrazide Chemical Structure

4-Aminobenzohydrazide Chemical Structure

CAS: 5351-17-7

Selleck's 4-Aminobenzohydrazide has been cited by 1 publication

Purity & Quality Control

Batch: S987401 DMSO] 30 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.96%
99.96

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Biological Activity

Description 4-Aminobenzohydrazide (4-Aminobenzhydrazide, 4-aminobenzoic acid hydrazide, 4-ABAH, Myeloperoxidase Inhibitor I, NSC 640) is an inhibitor of MPO (Myeloperoxidase) enzyme that enhances iNOS induction in MPO-positive cells, but not in MPO-KO cells.
Targets
MPO [1]
In vitro
In vitro

4-aminobenzohydrazide is an inhibitor of MPO enzyme that enhances iNOS induction in MPO-positive cells, but not in MPO-KO cells.[1]
Cell Research Cell lines bone marrow cells
Concentrations 0.1 μM, 10 μM, 100 μM, 200 μM
Incubation Time 8 h
Method

If MPO suppresses the induction of iNOS by IL, inhibitors of MPO enzyme activity should alleviate this suppression. To test this, bone marrow cells from TgM-POg and MPO-KO mice are incubated with IFNc/LPS for 8 h in the presence of increasing concentrations of 4-aminobenzohydrazide (ABAH).
In Vivo
In vivo

Hamsters treated with ABAH show no significant differences in the percentage of lesions or in the percentage of amoebae damaged compared with the untreated hamsters. ABAH treated mice versus untreated mice show larger abscesses and a decreased percentage of damaged amoebae in these lesion at all stages of evolution.[2]
Animal Research Animal Models 9 week-old Hamsters, 7–10 week-old male BALB/c mice
Dosages 40 mg/kg
Administration IP

Chemical Information & Solubility

Molecular Weight 151.17 Formula

C7H9N3O
CAS No. 5351-17-7 SDF --
Smiles NNC(=O)C1=CC=C(N)C=C1
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 30 mg/mL ( (198.45 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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