Auranofin

Catalog No.S4307 Synonyms: Ridaura, SKF39162

For research use only.

Auranofin (Ridaura, SKF-39162) is an inhibitor of thioredoxin reductase (TrxR) with IC50 of 88 nM for purified H. pylori TrxR in cell-free assay. Auranofin has anti-cancer activity and can completely inhibit bacterial growth at 1.2 μM. Auranofin is an FDA-approved gold-containing compound used for the treatment of rheumatoid arthritis.

Auranofin Chemical Structure

CAS No. 34031-32-8

Selleck's Auranofin has been cited by 1 Publication

Purity & Quality Control

Choose Selective Bacterial Inhibitors

Biological Activity

Description Auranofin (Ridaura, SKF-39162) is an inhibitor of thioredoxin reductase (TrxR) with IC50 of 88 nM for purified H. pylori TrxR in cell-free assay. Auranofin has anti-cancer activity and can completely inhibit bacterial growth at 1.2 μM. Auranofin is an FDA-approved gold-containing compound used for the treatment of rheumatoid arthritis.
Targets
TrxR [1]
(Cell-free assay)
88 nM

Protocol (from reference)

Chemical Information

Molecular Weight 678.48
Formula

C20H34AuO9PS

CAS No. 34031-32-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCP(CC)CC.CC(=O)OCC1C(C(C(C(O1)[S-])OC(=O)C)OC(=O)C)OC(=O)C.[Au+]

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02089048 Completed Drug: Auranofin Amoebiasis National Institute of Allergy and Infectious Diseases (NIAID) April 2 2014 Phase 1
NCT01747798 Completed Drug: auranofin|Other: laboratory biomarker analysis Recurrent Fallopian Tube Cancer|Recurrent Ovarian Epithelial Cancer|Recurrent Primary Peritoneal Cavity Cancer Mayo Clinic November 2 2012 Early Phase 1
NCT01419691 Completed Drug: auranofin Chronic Lymphocytic Leukemia (CLL)|Small Lymphocytic Lymphoma|Leukemia Prolymphocytic University of Kansas Medical Center|The Leukemia and Lymphoma Society|Kansas Bioscience Authority|Therapeutics for Rare and Neglected Diseases (TRND) September 2011 Phase 2
NCT02176135 Withdrawn Drug: Auranofin HIV Vaccine and Gene Therapy Institute Florida|University of Miami Phase 1|Phase 2

(data from https://clinicaltrials.gov, updated on 2022-11-29)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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