Name: Auranofin
Brand: Selleck Chemicals
SKU: S4307
Rating: 5 (3 reviews)

Auranofin is an inhibitor of thioredoxin reductase (TrxR) with IC50 of 88 nM for purified H. pylori TrxR in cell-free assay. Auranofin has anti-cancer activity and can completely inhibit bacterial growth at 1.2 μM. Auranofin is an FDA-approved gold-containing compound used for the treatment of rheumatoid arthritis.

Auranofin Chemical Structure

CAS: 34031-32-8

Selleck's Auranofin has been cited by 3 publications

Purity & Quality Control

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Choose Selective Bacterial Inhibitors

Biological Activity

Description

Auranofin is an inhibitor of thioredoxin reductase (TrxR) with IC50 of 88 nM for purified H. pylori TrxR in cell-free assay. Auranofin has anti-cancer activity and can completely inhibit bacterial growth at 1.2 μM. Auranofin is an FDA-approved gold-containing compound used for the treatment of rheumatoid arthritis.

Targets

TrxR ^[1]
(Cell-free assay)

88 nM

In vitro
In vitro	Auranofin (Ridaura, SKF-39162) is an inhibitor of thioredoxin reductase (TrxR) with IC50 of 88 nM for purified H. pylori TrxR in cell-free assay.

In Vivo
In vivo	Auranofin is a small molecule inhibitor of NONO that suppressed GBM tumor growth in an orthotopic xenograft model in mice.
Animal Research	Animal Models	Athymic nude mice
	Dosages	5 or 10 mg/kg
	Administration	o.g.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT02089048	Completed	Amoebiasis	National Institute of Allergy and Infectious Diseases (NIAID)	April 2 2014	Phase 1
NCT01747798	Completed	Recurrent Fallopian Tube Cancer\|Recurrent Ovarian Epithelial Cancer\|Recurrent Primary Peritoneal Cavity Cancer	Mayo Clinic	November 2 2012	Early Phase 1
NCT01419691	Completed	Chronic Lymphocytic Leukemia (CLL)\|Small Lymphocytic Lymphoma\|Leukemia Prolymphocytic	University of Kansas Medical Center\|The Leukemia and Lymphoma Society\|Kansas Bioscience Authority\|Therapeutics for Rare and Neglected Diseases (TRND)	September 2011	Phase 2
NCT02176135	Withdrawn	HIV	Vaccine and Gene Therapy Institute Florida\|University of Miami		Phase 1\|Phase 2

References

Chemical Information & Solubility

Molecular Weight	678.48	Formula	C₂₀H₃₄AuO₉PS
CAS No.	34031-32-8	SDF	Download Auranofin SDF
Smiles	CCP(CC)CC.CC(=O)OCC1C(C(C(C(O1)[S-])OC(=O)C)OC(=O)C)OC(=O)C.[Au+]
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 100 mg/mL ( (147.38 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 100 mg/mL

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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