Home GPCR & G Protein GHSR agonist AnaMorelin hydrochloride

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AnaMorelin hydrochloride GHSR agonist

Cat.No.E4923

Anamorelin hydrochloride(RC-1291 HCL, ONO-7643) is a potent and selective agonist of ghrelin receptor with EC50 of 0.74 nM FLIPR assay. It has a significant appetite-enhancing activity and has the potential to treat cancer anorexia-cachexia syndrome.
AnaMorelin hydrochloride GHSR agonist Chemical Structure

Chemical Structure

Molecular Weight: 583.17

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Quality Control

Batch: E492301 DMSO]100 mg/mL]false]Water]100 mg/mL]false]Ethanol]100 mg/mL]false Purity: 98.96%
98.96

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (171.47 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 100 mg/mL

Ethanol : 100 mg/mL

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 583.17 Formula

C31H42N6O3.ClH

 Storage (From the date of receipt)
CAS No. 861998-00-7 Download SDF Storage of Stock Solutions

Read more about storage stability stock solution CAS number

Mechanism of Action

Targets/IC50/Ki
ghrelin receptor
0.74 nM(EC50)
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-04-15)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03637816 ACTIVE_NOT_RECRUITING
Anorexia; Lung Non-Small Cell Carcinoma; Stage III Lung Cancer AJCC v8; Stage IIIA Lung Cancer AJCC v8; Stage IIIB Lung Cancer AJCC v8; Stage IIIC Lung Cancer AJCC v8; Stage IV Lung Cancer AJCC v8; Stage IVA Lung Cancer AJCC v8; Stage IVB Lung Cancer AJCC v8
M.D. Anderson Cancer Center
 2018-11-27 PHASE2; PHASE3
NCT04844970 TERMINATED
Metastatic Pancreatic Cancer
Lahey Clinic
 2023-04-01 PHASE2
NCT03743051 COMPLETED
Cachexia; Cancer; Non Small Cell Lung Cancer
Helsinn Healthcare SA
 2019-03-05 PHASE3
NCT04021706 COMPLETED
Sarcopenia; Osteopenia
Tufts University
 2019-12-05 PHASE1
NCT03743064 COMPLETED
Cachexia; Cancer; Non Small Cell Lung Cancer
Helsinn Healthcare SA
 2019-05-06 PHASE3
NCT03035409 ACTIVE_NOT_RECRUITING
Advanced Malignant Solid Neoplasm; C-Reactive Protein Measurement; Cancer Fatigue; Metastatic Malignant Solid Neoplasm; Recurrent Malignant Solid Neoplasm; Weight Loss
M.D. Anderson Cancer Center
 2017-02-08 PHASE2

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