For research use only.

Catalog No.S7339

10 publications

AZD3965 Chemical Structure

CAS No. 1448671-31-5

AZD3965 is a potent, selective and orally available monocarboxylate transporter 1 (MCT1) inhibitor with a binding affinity of 1.6 nM, 6-fold selective over MCT2. Phase 1.

Selleck's AZD3965 has been cited by 10 publications

1 Customer Review

  • Lactate release by SiHa-WT cells treated with AR-C155858 (left; n = 8-9) or AZD3965 (right; n = 5-6) versus vehicle.

    Cancer Res, 2017, 77(20):5591-5601. AZD3965 purchased from Selleck.

Purity & Quality Control

Choose Selective MCT Inhibitors

Biological Activity

Description AZD3965 is a potent, selective and orally available monocarboxylate transporter 1 (MCT1) inhibitor with a binding affinity of 1.6 nM, 6-fold selective over MCT2. Phase 1.
MCT1 [1]
In vitro

In lymphoma cell lines that preferentially express MCT1, AZD3965 potently inhibits lactate transport and cell growth. [1] AZD3965 inhibits MCT1 activity in cells, and shows higher sensitivity in hypoxia. [2] In H526, HGC27 cells and DMS114 cells, AZD3965 increases intracellular lactate and significantly reduces lactate uptake. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Raji Mki3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGXvcI84OiCq M1ri[mdKPTB;MUKuN|Uhdk1? M1rrSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MEWwNVk6Lz5{OUC1NFE6QTxxYU6=
WSU-DLCL-2 M2r4RWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYHIe2gzPzJiaB?= MoPrS2k2OD14LkGxJI5O NFHDUXI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUC1NFE6QSd-MkmwOVAyQTl:L3G+
SU-DHL-10 NYLrdlNxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1v4V|czKGh? M1LhTmdKPTB;ND6yNkBvVQ>? NFPwdWs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUC1NFE6QSd-MkmwOVAyQTl:L3G+
Karpas-422 NVj6OII5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mn2wO|IhcA>? MmXQS2k2OD1|OUWuN|ghdk1? NWj1TVhiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmwOVAyQTlpPkK5NFUxOTl7PD;hQi=>
Hut78 NW\sVXJiTnWwY4Tpc44h[XO|YYm= MWS1MEAzPSxiNUCwJI5O MYCyOEBp MmexNlRpKGW6cH;zeZJmKHSxIHGgcI94KGOxbnPlcpRz[XSrb36gc4YhSVqGM{m2OUApPW6PKTDs[YQhfG9iYTCxNE1nd2ymIHL1bYxlNXWyIHnuJGxi[3SjdHXJJIlvKE2FVESrJGh2fDd6IHj1cYFvKGy7bYDoc41iKGOnbHzzMEB4cGmlaDD3ZZMhe3W|dHHpcoVlKGG2IHjp[4hmeiCmcoXnJINwdmOnboTyZZRqd26|IDiyOY5OKGGwZDC1NFBvVSl? NEiwcok9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEmyN|g3OSd-Mki5NlM5PjF:L3G+
HT29 NWfxWHhRTnWwY4Tpc44h[XO|YYm= MmD2OUwhOjVuIEWwNEBvVQ>? MoHtNlQhcA>? NIr4WXNE\WyuczDzbI94\WRiYTD0doVv\CC2b4fhdoR{KGGwIHnuZ5Jm[XOnIHnuJGxi[3SjdHXJJJJmdGG2aY\lJJRwKGOxboTyc4x{KHerdHigOY5OKGGwZDCyOY5OKEGcREO5OlUhf2irY3igc45tgSCkZXPhcYUhe2mpbnnmbYNidnRid3n0bEBmgHCxc4Xy[UB1dyB3MECgcm0hSVqGM{m2OUBz\WGlaHnu[{B2eCC2bzC0MYZwdGRuIILlcIF1cX[nIITvJINwdnS{b3zzMi=> Mn23QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh7MkO4OlEoRjJ6OUKzPFYyRC:jPh?=

... Click to View More Cell Line Experimental Data

Methods Test Index PMID
Growth inhibition assay
Cell viability ; 

PubMed: 29050199     

AZD3965 monotherapy phenotypic activity. Cell growth was assessed through viable cell number 72 hr post AZD3965 treatment. GI50 values +/- s.e.

In vivo In nonobese diabetic scid-γ mice bearing COR-L103 xenografts, AZD3965 (100 mg/kg, p.o.) reduces tumor growth and increased intratumor lactate. [2] In mice bearing H526 tumors, AZD3965 (100 mg/kg, p.o.) causes increased lactate concentration, a reduction in growth and increased radiation sensitivity. [3]


Animal Research:[2]
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  • Animal Models: Nonobese diabetic scid-γ mice bearing COR-L103 xenografts
  • Dosages: 100 mg/kg
  • Administration: p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (193.98 mM)
Ethanol 100 mg/mL (193.98 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 515.51


CAS No. 1448671-31-5
Storage powder
in solvent
Synonyms N/A
Smiles CC1=C(C(=NN1)C(F)(F)F)CC2=C(C3=C(S2)N(C(=O)N(C3=O)C)C(C)C)C(=O)N4CC(CO4)(C)O

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01791595 Completed Drug: AZD3965 Adult Solid Tumor|Diffuse Large B Cell Lymphoma|Burkitt Lymphoma Cancer Research UK February 2013 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID