Catalog No.S7339

For research use only.

AZD3965 is a potent, selective and orally available monocarboxylate transporter 1 (MCT1) inhibitor with a binding affinity of 1.6 nM, 6-fold selective over MCT2. Phase 1.

AZD3965 Chemical Structure

CAS No. 1448671-31-5

Selleck's AZD3965 has been cited by 10 Publications

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Purity & Quality Control

Choose Selective MCT Inhibitors

Biological Activity

Description AZD3965 is a potent, selective and orally available monocarboxylate transporter 1 (MCT1) inhibitor with a binding affinity of 1.6 nM, 6-fold selective over MCT2. Phase 1.
MCT1 [1]
In vitro

In lymphoma cell lines that preferentially express MCT1, AZD3965 potently inhibits lactate transport and cell growth. [1] AZD3965 inhibits MCT1 activity in cells, and shows higher sensitivity in hypoxia. [2] In H526, HGC27 cells and DMS114 cells, AZD3965 increases intracellular lactate and significantly reduces lactate uptake. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Raji MXfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MknZO|IhcA>? MVvHTVUxRTF{LkO1JI5O NWrYRmZPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmwOVAyQTlpPkK5NFUxOTl7PD;hQi=>
WSU-DLCL-2 NWP5cHBwT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3q4XFczKGh? NHzCNIdIUTVyPU[uNVEhdk1? NHjqXWk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUC1NFE6QSd-MkmwOVAyQTl:L3G+
SU-DHL-10 M3n2XGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHTJS2g4OiCq M1rQXWdKPTB;ND6yNkBvVQ>? MonhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjlyNUCxPVkoRjJ7MEWwNVk6RC:jPh?=
Karpas-422 NVPweHJiT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYe3NkBp Mn7ZS2k2OD1|OUWuN|ghdk1? NG\yWGE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUC1NFE6QSd-MkmwOVAyQTl:L3G+
Hut78 NEPSXY1HfW6ldHnvckBie3OjeR?= NGXHemU2NCB{NTygOVAxKG6P M2TqeFI1KGh? M1vFdVI1cCCneIDvd5Vz\SC2bzDhJIxwfyClb37j[Y51emG2aX;uJI9nKEGcREO5OlUhMDWwTTmgcIVlKHSxIHGgNVAu\m:uZDDieYlt\C23cDDpckBN[WO2YYTlTUBqdiCPQ2S0L{BJfXR5ODDoeY1idiCueX3wbI9u[SClZXzsd{whf2irY3ige4F{KHO3c4ThbY5m\CCjdDDobYdp\XJiZIL1[{Bkd26lZX70doF1cW:wczCoNlVvVSCjbnSgOVAxdk1r NGDwbXU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEmyN|g3OSd-Mki5NlM5PjF:L3G+
HT29 MkXhSpVv[3Srb36gZZN{[Xl? MXm1MEAzPSxiNUCwJI5O NVLZd5IzOjRiaB?= NHiyb|VE\WyuczDzbI94\WRiYTD0doVv\CC2b4fhdoR{KGGwIHnuZ5Jm[XOnIHnuJGxi[3SjdHXJJJJmdGG2aY\lJJRwKGOxboTyc4x{KHerdHigOY5OKGGwZDCyOY5OKEGcREO5OlUhf2irY3igc45tgSCkZXPhcYUhe2mpbnnmbYNidnRid3n0bEBmgHCxc4Xy[UB1dyB3MECgcm0hSVqGM{m2OUBz\WGlaHnu[{B2eCC2bzC0MYZwdGRuIILlcIF1cX[nIITvJINwdnS{b3zzMi=> M1HKV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OUKzPFYyLz5{OEmyN|g3OTxxYU6=
Methods Test Index PMID
Growth inhibition assay Cell viability 29050199
In vivo In nonobese diabetic scid-γ mice bearing COR-L103 xenografts, AZD3965 (100 mg/kg, p.o.) reduces tumor growth and increased intratumor lactate. [2] In mice bearing H526 tumors, AZD3965 (100 mg/kg, p.o.) causes increased lactate concentration, a reduction in growth and increased radiation sensitivity. [3]

Protocol (from reference)

Animal Research:[2]
  • Animal Models: Nonobese diabetic scid-γ mice bearing COR-L103 xenografts
  • Dosages: 100 mg/kg
  • Administration: p.o.

Solubility (25°C)

In vitro

DMSO 100 mg/mL
(193.98 mM)
Ethanol 100 mg/mL
(193.98 mM)
Water Insoluble

Chemical Information

Molecular Weight 515.51


CAS No. 1448671-31-5
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=C(C(=NN1)C(F)(F)F)CC2=C(C3=C(S2)N(C(=O)N(C3=O)C)C(C)C)C(=O)N4CC(CO4)(C)O

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01791595 Completed Drug: AZD3965 Adult Solid Tumor|Diffuse Large B Cell Lymphoma|Burkitt Lymphoma Cancer Research UK February 2013 Phase 1

(data from, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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