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Asaraldehyde COX inhibitor

Cat.No.S2531

Asaraldehyde (Asaronaldehyde) is a natural COX-2 inhibitor, exhibiting 17-fold selectivity over COX-1.
Asaraldehyde COX inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 196.2

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Quality Control

Batch: S253101 DMSO]39 mg/mL]false]Ethanol]16 mg/mL]false]Water]Insoluble]false Purity: 100%
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100

Solubility

In vitro
Batch:

DMSO : 39 mg/mL (198.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 16 mg/mL

Water : Insoluble

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 196.2 Formula

C10H12O4

 Storage (From the date of receipt)
CAS No. 4460-86-0 Download SDF Storage of Stock Solutions

Synonyms Asaronaldehyde Smiles COC1=CC(=C(C=C1C=O)OC)OC

Mechanism of Action

Targets/IC50/Ki
COX-2
In vitro
Asaraldehyde is found to be the most abundant constituent, but is totally absent in its cultured broth and its natural host, C. kanehirae wood. On feeding with the acid-digested sawdust of C. kanehirae wood or vanillin to the broth for culture, this compound is produced in both cultured broths. It shows 3.32% of prostaglandin H endoperoxide synthase-1 (COX-1) inhibitory activity and 52.69% prostaglandin H endoperoxide synthase-2 (COX-2) inhibitory activity, respectively at 100 mg/mL. This chemical shows selectivity towards COX-2 enzyme inhibition at 100 µg/mL. The COX-2/COX-1 ratio for it is 17.68 at 100 µg/mL compared to solvent control. This compound down-regulates C/EBPβ, C/EBPδ, and C/EBPα. It suppresses expression of PPARγ1 and PPARγ2. It also significantly suppresses the expression of acetyl-CoA carboxylase (ACC).
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