Azacyclonol

Catalog No.S3196 Synonyms: MER 17, MDL 4829

For research use only.

Azacyclonol (MER 17, MDL 4829), also known as γ-pipradol, is a drug used to diminish hallucinations in psychotic individuals.

Azacyclonol Chemical Structure

CAS No. 115-46-8

Selleck's Azacyclonol has been cited by 1 Publication

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Biological Activity

Description Azacyclonol (MER 17, MDL 4829), also known as γ-pipradol, is a drug used to diminish hallucinations in psychotic individuals.
In vitro

The formation of Azacyclonol in human intestinal microsomes is linear with respect to time up to 60 min. The rates of formation of Azacyclonol increases linearly with microsomal protein concentration up to 2 mg/mL. The apparent Km and Vmax values of Azacyclonol are 0.82 μM and 60 pmol/min/mg protein in microsomes from human liver. [1] The formation of Azacyclonol and terfenadine alcohol from terfenadine is confirmed to be catalyzed predominantly by CYP3A(4) isozyme, and the ratio of the rate of terfenadine alcohol formation to that of Azacyclonol is 3:1. [2] The amount of Azacyclonol eliminated renally increases on average 2-fold after rifampin dosing. [3]

In vivo Azacyclonol (i.v.) impairs the response of the nictitating membrane to both post- and preganglionic stimulation. The activity of Azacyclonol in depressing transmission through the cat superior ceivical ganglion is 6.63%. [4]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 267.37
Formula

C18H21NO

CAS No. 115-46-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1CNCCC1C(C2=CC=CC=C2)(C3=CC=CC=C3)O

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