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Azacyclonol

Name: Azacyclonol
Brand: Selleck Chemicals
SKU: S3196
Rating: 5 (2 reviews)

Synonyms: MER 17, MDL 4829

Catalog No.S3196 Purity: 99.99%

Azacyclonol (MER 17, MDL 4829), also known as γ-pipradol, is a drug used to diminish hallucinations in psychotic individuals.

Azacyclonol Chemical Structure

CAS: 115-46-8

Selleck's Azacyclonol has been cited by 2 publications

Purity & Quality Control

Batch: S319601 DMSO] 53 mg/mL] false] Ethanol] 53 mg/mL] false] Water] 2 mg/mL] false Purity: 99.99%

99.99

Azacyclonol Related Products

Related Targets	5-HT1 5-HT2 5-HT3 5-HT4 5-HT6 5-HT7 5-HT5	Click to Expand
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Signaling Pathway

5-HT Receptor Signaling Pathway

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Biological Activity

Description	Azacyclonol (MER 17, MDL 4829), also known as γ-pipradol, is a drug used to diminish hallucinations in psychotic individuals.

In vitro
In vitro	The formation of Azacyclonol in human intestinal microsomes is linear with respect to time up to 60 min. The rates of formation of Azacyclonol increases linearly with microsomal protein concentration up to 2 mg/mL. The apparent Km and Vmax values of Azacyclonol are 0.82 μM and 60 pmol/min/mg protein in microsomes from human liver. ^[1] The formation of Azacyclonol and terfenadine alcohol from terfenadine is confirmed to be catalyzed predominantly by CYP3A(4) isozyme, and the ratio of the rate of terfenadine alcohol formation to that of Azacyclonol is 3:1. ^[2] The amount of Azacyclonol eliminated renally increases on average 2-fold after rifampin dosing. ^[3]

In Vivo
In vivo	Azacyclonol (i.v.) impairs the response of the nictitating membrane to both post- and preganglionic stimulation. The activity of Azacyclonol in depressing transmission through the cat superior ceivical ganglion is 6.63%. ^[4]

References

[4] Brown DA, et al. Br J Pharmacol Chemother, 1964, 23(2), 241-256.

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Chemical Information & Solubility

Molecular Weight	267.37	Formula	C₁₈H₂₁NO
CAS No.	115-46-8	SDF	Download Azacyclonol SDF
Smiles	C1CNCCC1C(C2=CC=CC=C2)(C3=CC=CC=C3)O
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 53 mg/mL ( (198.22 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 53 mg/mL

Water : 2 mg/mL

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In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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