Home Neuronal Signaling 5-HT Receptor chemical Azacyclonol

research use only

Azacyclonol 5-HT Receptor chemical

Azacyclonol (MER 17, MDL 4829), also known as γ-pipradol, is a drug used to diminish hallucinations in psychotic individuals.

Azacyclonol 5-HT Receptor chemical Chemical Structure

Chemical Structure

Molecular Weight: 267.37

Purity & Quality Control

Batch: S319601 DMSO]53 mg/mL]false]Ethanol]53 mg/mL]false]Water]2 mg/mL]false Purity: 99.99%
99.99

Related Products

Signaling Pathway

5-HT Receptor Signaling Pathways

5-HT Receptor Signaling Pathway

Mechanism of Action

In vitro
In vitro The formation of Azacyclonol in human intestinal microsomes is linear with respect to time up to 60 min. The rates of formation of this compound increases linearly with microsomal protein concentration up to 2 mg/mL. The apparent Km and Vmax values of this chemical are 0.82 μM and 60 pmol/min/mg protein in microsomes from human liver. [1] The formation of this compound and terfenadine alcohol from terfenadine is confirmed to be catalyzed predominantly by CYP3A(4) isozyme, and the ratio of the rate of terfenadine alcohol formation to that of this chemical is 3:1. [2] The amount of this compound eliminated renally increases on average 2-fold after rifampin dosing. [3]

In Vivo
In vivo Azacyclonol (i.v.) impairs the response of the nictitating membrane to both post- and preganglionic stimulation. The activity of this compound in depressing transmission through the cat superior ceivical ganglion is 6.63%. [4]

References
  • https://pubmed.ncbi.nlm.nih.gov/9279883/
  • https://pubmed.ncbi.nlm.nih.gov/7587944/
  • https://pubmed.ncbi.nlm.nih.gov/11240975/
  • https://pubmed.ncbi.nlm.nih.gov/19108183/

Chemical Information

Molecular Weight 267.37 Formula

C18H21NO
CAS No. 115-46-8 SDF Download SDF
Synonyms MER 17, MDL 4829
Smiles C1CNCCC1C(C2=CC=CC=C2)(C3=CC=CC=C3)O

Storage and Stability

Storage (From the date of receipt)

In vitro
Batch:

DMSO : 53 mg/mL ( (198.22 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 53 mg/mL

Water : 2 mg/mL


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.