Home Neuronal Signaling 5-HT Receptor chemical Azacyclonol

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Azacyclonol 5-HT Receptor chemical

Cat.No.S3196

Azacyclonol (MER 17, MDL 4829), also known as γ-pipradol, is a drug used to diminish hallucinations in psychotic individuals.
Azacyclonol 5-HT Receptor chemical Chemical Structure

Chemical Structure

Molecular Weight: 267.37

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Quality Control

Batch: S319601 DMSO]53 mg/mL]false]Ethanol]53 mg/mL]false]Water]2 mg/mL]false Purity: 99.99%
99.99

Chemical Information, Storage & Stability

Molecular Weight 267.37 Formula

C18H21NO

 Storage (From the date of receipt)
CAS No. 115-46-8 Download SDF Storage of Stock Solutions

Synonyms MER 17, MDL 4829 Smiles C1CNCCC1C(C2=CC=CC=C2)(C3=CC=CC=C3)O

Solubility

In vitro
Batch:

DMSO : 53 mg/mL ( (198.22 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 53 mg/mL

Water : 2 mg/mL

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Mechanism of Action

In vitro
The formation of Azacyclonol in human intestinal microsomes is linear with respect to time up to 60 min. The rates of formation of this compound increases linearly with microsomal protein concentration up to 2 mg/mL. The apparent Km and Vmax values of this chemical are 0.82 μM and 60 pmol/min/mg protein in microsomes from human liver. [1] The formation of this compound and terfenadine alcohol from terfenadine is confirmed to be catalyzed predominantly by CYP3A(4) isozyme, and the ratio of the rate of terfenadine alcohol formation to that of this chemical is 3:1. [2] The amount of this compound eliminated renally increases on average 2-fold after rifampin dosing. [3]
In vivo
Azacyclonol (i.v.) impairs the response of the nictitating membrane to both post- and preganglionic stimulation. The activity of this compound in depressing transmission through the cat superior ceivical ganglion is 6.63%. [4]
References

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