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ADOX (Adenosine Dialdehyde) Transferase inhibitor

Cat.No.S8608

ADOX (Adenosine Dialdehyde) is an adenosine analog and a S-adenosylmethionine-dependent methyltransferase inhibitor with an IC50 of 40 nM.
ADOX (Adenosine Dialdehyde) Transferase inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 265.23

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Chemical Information, Storage & Stability

Molecular Weight 265.23 Formula

C10H11N5O4

 Storage (From the date of receipt)
CAS No. 34240-05-6 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles C1=NC(=C2C(=N1)N(C=N2)C(C=O)OC(CO)C=O)N

Solubility

In vitro
Batch:

DMSO : 19 mg/mL (71.63 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Mechanism of Action

Targets/IC50/Ki
AdoHcy hydrolase [1]
(Cell-free)
40 nM
In vitro
Adenosine dialdehyde (AdOx), an indirect inhibitor that can be incorporated by cells, inhibits S-adenosyl-L-homocystein hydrolase, resulting in the accumulation of S-adenosyl-L-homo cystein (Adoicy), a product inhibitor of methyltransferases that utilize S-adenosyl-L-methionine (AdoMet) as the methyl group donor[2]. This compound inhibited the Tax-activated NF-κB pathway, resulting in reactivation of p53 and induction of p53 target genes. Analysis of the NF-κB pathway demonstrated that AdOx treatment resulted in degradation of the IκB kinase complex and inhibition of NF-κB through stabilization of the NF-κB inhibitor IκBα. It induced G2/M cell cycle arrest and cell death in HTLV-1-transformed but not control lymphocytes[4].
In vivo
AdOx (Adenosine Dialdehyde) exerts a potent inhibitory effect on the in situ growth of established murine neuroblastoma (MNB) tumors, prolongs the life span of tumor bearing mice, and does not suppress hematopoiesis when administered by steady state infusion. It inhibits the replication of L1210 leukemia cells and increased life span approximately 40% when administered i.p. at a dose of 20 mg/kg/day until death[3].
References

Applications

Methods Biomarkers Images PMID
Western blot p-Tau / Tau AUF1 S8608-WB1 23943618

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