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Amodiaquine Parasite inhibitor

Cat.No.S5948

Amodiaquine is a synthetic aminoquinoline that acts by binding to the protozoal or parasitic DNA and preventing DNA and RNA production and subsequent protein synthesis. It is used for the therapy of malaria.
Amodiaquine Parasite inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 355.86

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Quality Control

Batch: S594801 DMSO]71 mg/mL]false]Ethanol]22 mg/mL]false]Water]Insoluble]false Purity: 99.50%
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99.50

Solubility

In vitro
Batch:

DMSO : 71 mg/mL (199.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 22 mg/mL

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight
Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg
g
μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO
%
% Tween 80
% ddH2O
% DMSO
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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 355.86 Formula

C20H22ClN3O

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 86-42-0 -- Storage of Stock Solutions

Synonyms N/A Smiles CCN(CC)CC1=C(C=CC(=C1)NC2=C3C=CC(=CC3=NC=C2)Cl)O

Mechanism of Action

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05979896 Recruiting
Malaria
Malaria Consortium
 July 28 2023 Phase 4
NCT05478954 Active not recruiting
Malaria
Malaria Consortium
 July 15 2022 Phase 4
NCT05471544 Active not recruiting
Malaria
Malaria Consortium
 July 18 2022 Phase 3
NCT05343312 Active not recruiting
Malaria
Centro de Investigacao em Saude de Manhica|United States Agency for International Development (USAID)
 March 16 2022 Phase 4
NCT04002687 Completed
Malaria
Medicines for Malaria Venture|Richmond Pharmacology Limited
 April 4 2019 Phase 1

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