For research use only.
CAS No. 86-42-0
Amodiaquine is a synthetic aminoquinoline that acts by binding to the protozoal or parasitic DNA and preventing DNA and RNA production and subsequent protein synthesis. It is used for the therapy of malaria.
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|Description||Amodiaquine is a synthetic aminoquinoline that acts by binding to the protozoal or parasitic DNA and preventing DNA and RNA production and subsequent protein synthesis. It is used for the therapy of malaria.|
|In vitro||DMSO||71 mg/mL (199.51 mM)|
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|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
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|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04002687||Completed||Drug: ATV-PG 1000-400 mg + AQ 612 mg||Malaria||Medicines for Malaria Venture|Richmond Pharmacology Limited||April 4 2019||Phase 1|
|NCT01328990||Completed||Drug: sulfadoxine-pyrimethamine plus amodiaquine||Malaria||London School of Hygiene and Tropical Medicine|Cheikh Anta Diop University Senegal||April 2011||Phase 1|Phase 2|
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