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Amodiaquine Parasite inhibitor

Cat.No.S5948

Amodiaquine is a synthetic aminoquinoline that acts by binding to the protozoal or parasitic DNA and preventing DNA and RNA production and subsequent protein synthesis. It is used for the therapy of malaria.
Amodiaquine Parasite inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 355.86

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Quality Control

Batch: S594801 DMSO]71 mg/mL]false]Ethanol]22 mg/mL]false]Water]Insoluble]false Purity: 99.50%
99.50

Solubility

In vitro
Batch:

DMSO : 71 mg/mL (199.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 22 mg/mL

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight
Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO
%
% Tween 80
% ddH2O
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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 355.86 Formula

C20H22ClN3O

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 86-42-0 -- Storage of Stock Solutions

Synonyms N/A SMILES CCN(CC)CC1=C(C=CC(=C1)NC2=C3C=CC(=CC3=NC=C2)Cl)O

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Mechanism of Action

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-01-07)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT07322068 NOT_YET_RECRUITING
Malaria, Falciparum
Stanford University
 2026-09 PHASE4
NCT06967519 RECRUITING
Malaria; Hiv
Yale University
 2025-12-18 PHASE4
NCT05951595 RECRUITING
Uncomplicated Plasmodium Falciparum Malaria
University of Oxford
 2025-09-11 PHASE3
NCT06083688 COMPLETED
Malaria,Falciparum; Anemia in Children
Liverpool School of Tropical Medicine
 2024-10-14 PHASE4
NCT04080895 TERMINATED
Pharmacokinetic; Healthy; Drug Combination
University of Oxford
 2022-11-01 PHASE1
NCT05764746 COMPLETED
Uncomplicated Plasmodium Falciparum Malaria
Muhimbili University of Health and Allied Sciences
 2023-05-01 PHASE2; PHASE3

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