Amodiaquine

Catalog No.S5948

For research use only.

Amodiaquine is a synthetic aminoquinoline that acts by binding to the protozoal or parasitic DNA and preventing DNA and RNA production and subsequent protein synthesis. It is used for the therapy of malaria.

Amodiaquine Chemical Structure

CAS No. 86-42-0

Selleck's Amodiaquine has been cited by 4 Publications

Purity & Quality Control

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Biological Activity

Description Amodiaquine is a synthetic aminoquinoline that acts by binding to the protozoal or parasitic DNA and preventing DNA and RNA production and subsequent protein synthesis. It is used for the therapy of malaria.

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 355.86
Formula

C20H22ClN3O

CAS No. 86-42-0
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCN(CC)CC1=C(C=CC(=C1)NC2=C3C=CC(=CC3=NC=C2)Cl)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05478954 Recruiting Drug: Sulfadoxine pyrimethamine|Drug: Amodiaquine Malaria Malaria Consortium July 15 2022 Phase 4
NCT05471544 Not yet recruiting Drug: Sulfadoxine pyrimethamine|Drug: Amodiaquine Malaria Malaria Consortium July 30 2022 Phase 3
NCT05343312 Recruiting Drug: AL (Coartem)|Drug: AS-AQ (Carsucam)|Drug: DHP|Drug: PA Malaria Centro de Investigacao em Saude de Manhica|United States Agency for International Development (USAID) March 16 2022 Phase 4
NCT04002687 Completed Drug: ATV-PG 1000-400 mg + AQ 612 mg Malaria Medicines for Malaria Venture|Richmond Pharmacology Limited April 4 2019 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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