Abemaciclib mesylate (LY2835219)

Catalog No.S7158

For research use only.

Abemaciclib (LY2835219) is a potent and selective inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM in cell-free assays, respectively. Phase 3.

Abemaciclib mesylate (LY2835219) Chemical Structure

CAS No. 1231930-82-7

Selleck's Abemaciclib mesylate (LY2835219) has been cited by 58 publications

Purity & Quality Control

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Biological Activity

Description Abemaciclib (LY2835219) is a potent and selective inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM in cell-free assays, respectively. Phase 3.
Targets
CDK4 [1]
(Cell-free assay)
CDK6 [1]
(Cell-free assay)
2 nM 10 nM
In vitro

LY2835219 is an orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. LY2835219 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation in early G1. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of the serine/threonine kinases CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human COLO205 cells MVLGeY5kfGmxbjDhd5NigQ>? MYqyOEBp MYrJcohq[mm2aX;uJI9nKEOGS{SvOkBqdiCqdX3hckBEV0yRMkC1JINmdGy|IHHzd4V{e2WmIHHzJI1igGmvdX2gZ4VtdCCleXPs[UBienKnc4SgZZQhTzFicHjhd4Uh[W[2ZYKgNlQhcHK|IHL5JJBzd3CrZHn1cUBqd2SrZHWgd5RicW6rbnetZoF{\WRiZnzve{BkgXSxbXX0dolkKGGwYXz5d4l{ NXrQZ4pMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[xNVU2PzFpPkK2NVE2PTdzPD;hQi=>
human COLO205 cells MWXGeY5kfGmxbjDhd5NigQ>? NXvufZFPOjRiaB?= NFTMeGRKdmirYnn0bY9vKG:oIFPET|QwPiCrbjDoeY1idiCFT1zPNlA2KGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gVoIheGixc4Doc5J6dGG2aX;uJIFnfGW{IEK0JIhzeyCkeTDwdo9xcWSrdX2gbY9lcWSnIIP0ZYlvcW6pLXLhd4VlKGyjc3XyMZNk[W6waX7nJIZtfW:{ZYPj[Y5k\SCvaXPyc5Bt[XSnIHP5eI9u\XS{aXOgZY5idHm|aYO= NXzSOYd7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[xNVU2PzFpPkK2NVE2PTdzPD;hQi=>
insect cells  NHqyUlRHfW6ldHnvckBie3OjeR?= MX61NEBucW6| M4POO2lvcGmkaYTpc44hd2ZiaIXtZY4hS0SNND;jfYNtcW5iREGg[ZhxemW|c3XkJIlvKGmwc3XjeEBk\WyuczDhd5Nme3OnZDDhd{BxcG:|cHjvdplt[XSrb36gc4YhS1SURjDh[pRmeiB3MDDtbY5{KGK7IH3pZ5JweGyjdHWgd4NqdnSrbHzheIlwdiClb4XueIVzNCCLQ{WwQVIhdk1? MmnuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZzMUW1O|EoRjJ4MUG1OVcyRC:jPh?=
insect cells  M1HhNGZ2dmO2aX;uJIF{e2G7 MkjCOVAhdWmwcx?= NH2wWHZEd22yZYTpeIl3\SCrbnjpZol1cW:wIH;mJIh2dWGwIFPET|Qw[3mlbHnuJGQyKGW6cILld5Nm\CCrbjDpcpNm[3RiY3XscJMh[XO|ZYPz[YQh[XNicHjvd5Bpd3K7bHH0bY9vKG:oIFPUVmYh[W[2ZYKgOVAhdWmwczDifUBOcWOqYXXsbZMuVWWwdHXuJJBtd3RiYX7hcJl{cXNiaX6gdJJme2WwY3Wgc4YhSVSSLDDLbV0xNjZibl2= MofCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZzMUW1O|EoRjJ4MUG1OVcyRC:jPh?=
HCT116 MWfBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M4izPFczKGi{cx?= MXXJR|UxKD1iMD61OEDPxE1? M17QO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMU[1N|QyLz5|MEG2OVM1OTxxYU6=
MCF7 MULBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NX;pN2h{PzJiaILz NWTwVo1mUUN3MDC9JFAvPzFizszN NV\afVd4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CxOlU{PDFpPkOwNVY2OzRzPD;hQi=>
PANC1 MWDBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MUS3NkBpenN? NUTrO2pMUUN3MDC9JFUvQTRizszN M1W3OlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMU[1N|QyLz5|MEG2OVM1OTxxYU6=
Sf9 NHTCNXNHfW6ldHnvckBie3OjeR?= MUXJcohq[mm2aX;uJI9nKEOGS{GvR5lkdGmwIFKgLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO|ZXSgbY4h[mGldXzveolz[WxiaX7m[YN1\WRiaX7z[YN1KFOoOTDj[YxteyC3c3nu[{BpcXO2b37lJGgyKGG|IIP1ZpN1emG2ZTDpckBxemW|ZX7j[UBw\iCdZ3HtcYEuOzOSXVHUVEwhUUN3MDC9JFAvOzdzIN88UU4> MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjd2MUi1N{c,OjZ5NEG4OVM9N2F-
Sf9 NYntWGpNTnWwY4Tpc44h[XO|YYm= M{TWWVkxKG2rboO= NHSxZmpKdmirYnn0bY9vKG:oIILlZ49u[mmwYX70JIh2dWGwIF6teIVzdWmwYXygS3NVNXSjZ3fl[EBETEt2IDi0JJRwKDNyMzDy[ZNq\HWnczmvZ5lkdGmwIFSxJEg1KHSxIEK5OUBz\XOrZIXld{kh\XiycnXzd4VlKGmwIIPmPUBk\WyuczD1d4lv\yCFLYTldo1qdmGuIILleIlvd2KuYYP0c41iKG[{YXft[Y51KGG|IIP1ZpN1emG2ZTDh[pRmeiB7MDDtbY5{KGK7IGvnZY1u[S1|M2DdRXRRKGKjc3XkJI1q[3KxYnX0ZUB{[2mwdHnscIF1cW:wIHPveY51cW5uIFvpJF0hOC5yMEKg{txONg>? NVzQV25iRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkexO|ExOzZpPkK3NVcyODN4PD;hQi=>
Sf9 M4TS[GZ2dmO2aX;uJIF{e2G7 M3\H[VkxKG2rboO= MorQTY5pcWKrdHnvckBw\iC{ZXPvcYJqdmGwdDDmeYxtKGynbnf0bEBpfW2jbjDOMZRmem2rbnHsJGdUXC22YXfn[YQhS0SNNjCoNUB1dyB|Mk[gdoV{cWS3ZYOpM4N6[2yrbjDENUApPCC2bzCyPVUhemW|aXT1[ZMqKGW6cILld5Nm\CCrbjDz[lkh[2WubIOgeZNqdmdiQz30[ZJucW6jbDDy[ZRqdm:kbHHzeI9u[SCocnHncYVvfCCjczDzeYJ{fHKjdHWgZYZ1\XJiOUCgcYlveyCkeTDb[4FudWFvM{PQYWFVWCCkYYPl[EBucWO{b3LleIEhe2OrboTpcIxiNCCNaTC9JFAvODFizszNMi=> M3;TOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUexNFM3Lz5{N{G3NVA{PjxxYU6=
Sf21 NHny[FdHfW6ldHnvckBie3OjeR?= NEKyNXZKdmirYnn0bY9vKG:oIILlZ49u[mmwYX70JIh2dWGwIH\1cIwhdGWwZ4ToJGMufGW{bXnuZYwhUGm|Nj30ZYdo\WRiQ1TLO{9kgWOuaX6gTE9PNXSncn3pcoFtKEeVVD30ZYdo\WRiTVHUNUBmgHC{ZYPz[YQhcW5iYnHjeYxwfmm{dYOgbY5n\WO2ZXSgV4YzOSCrboPlZ5Qh[2WubIOgeZNqdmdiY3TrO{B{fWK|dILheIUheGWydHnk[UwhU2liPTCzMlkyKM7:TT6= M{nNWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUexNFM3Lz5{N{G3NVA{PjxxYU6=
COLO205 MVTBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NE\GdmE6PiCqcoO= MVrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEORTF:yNFUh[2WubIOgZYZ1\XJiOU[gbJJ{KGK7IFPDT{05KGG|c3H5MEBKSzVyIE2gNE41PiEQvF2u NIO2NlI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUC3OFI2PCd-MkmwO|QzPTR:L3G+
U87MG NUfxSGRISW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NXfxUHl7PzJiaILz MXvBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFV6N13HJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCGQWDJJJN1[WmwaX7nJIJie2WmIHHzd4F6NCCLQ{WwJF0hOC5yNEixJO69VS5? MnnFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl{NEe4OVcoRjJ7MkS3PFU4RC:jPh?=
Sf9 NX\LVVdmTnWwY4Tpc44h[XO|YYm= NXLSNINyUW6qaXLpeIlwdiCxZjDy[YNwdWKrbnHueEBpfW2jbjDOMZRmem2rbnHsJGdUXC22YXfn[YQhS0SNNDCoV|QhfG9iRUOwN{Bz\XOrZIXld{kwS3mlbHnuJGQyKCiTNDD0c{BKOjl3IILld4llfWW|KTDlfJBz\XO|ZXSgbY4he2Z7IHPlcIx{KHW|aX7nJHJjKHC{b4TlbY4hMDd5MzD0c{A6OjhicnXzbYR2\XNrIHHzJJN2[nO2cnH0[UBqdiCycnXz[Y5k\SCxZjDbN|NRZS2DVGCgZpkhe2OrboTpcIxifGmxbjDjc5VvfGmwZzDt[ZRpd2RuIFnDOVAhRSByLkCwNkDPxE1w MoLYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2Mkm4N|IoRjJ7NEK5PFMzRC:jPh?=
Sf9 NFrsUGhHfW6ldHnvckBie3OjeR?= M1X4WlkxKG2rboO= MYrJcohq[mm2aX;uJI9nKHKnY3;tZolv[W62IHj1cYFvKG[3bHygcIVv\3SqIFPET|Yh\XiycnXzd4VlKGmwIHLhZ5Vtd3[rcoXzJIlv\mWldHXkJHNnQSCrboPlZ5Qh[2WubIOgeZNqdmdiaHnzeI9v\SCKMTDzeYJ{fHKjdHWgZYZ1\XJiOUCgcYlveyCkeTDBSHAuT2yxIHHzd4F6NCCLQ{WwJF0hOC5yMEe4JO69VS5? NU\xPVhLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0Nlk5OzJpPkK5OFI6QDN{PD;hQi=>
Sf9 NVvQe2tkTnWwY4Tpc44h[XO|YYm= MV3Jcohq[mm2aX;uJI9nKHKnY3;tZolv[W62IHj1cYFvKE5vdHXycYlv[WxiR2PUMZRi\2enZDDDSGs1KCiPMTD0c{BCOzJ4IILld4llfWW|KT;DfYNtcW5iREGgLHE1KHSxIFmyPVUhemW|aXT1[ZMqKGW6cILld5Nm\CCrbjDz[lkh[2WubIOgeZNqdmdiUnKgdJJwfGWrbjCoO|c{KHSxIEmyPEBz\XOrZIXld{kh[XNic4Xid5Rz[XSnIHnuJJBz\XOnbnPlJI9nKFt|M2DdMWFVWCCkeTDzZ4lvfGmubHH0bY9vKGOxdX70bY5oKG2ndHjv[EwhUUN3MDC9JFAvODFizszNMi=> MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR{OUizNkc,Ojl2Mkm4N|I9N2F-
Sf9 MVvGeY5kfGmxbjDhd5NigQ>? MWK5NEBucW6| NIfkR45KdmirYnn0bY9vKG:oIILlZ49u[mmwYX70JIh2dWGwIH\1cIwhdGWwZ4ToJGNFUzFxQ4njcIlvKER|IHX4dJJme3OnZDDpckBj[WO3bH;2bZJ2eyCrbn\lZ5Rm\CCVZkmgbY5{\WO2IHPlcIx{KHW|aX7nJIhqe3SxbnWgTFEhe3Wkc4TyZZRmKGGodHXyJFkxKG2rboOgZpkhSUSSLVfsc{Bie3OjeTygTWM2OCB;IECuNFU3KM7:TT6= NHrBU4Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSyPVg{Oid-Mkm0Nlk5OzJ:L3G+
MDA-MB-231 MVPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFv MUO3NkBpenN? NH:wTFRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi1{M{GgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KESDUFmgd5RicW6rbnegZoF{\WRiYYPzZZktKEmFNUCgQUAxNjF7MTFOwG0v M2jSclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEK5PFMzLz5{OUSyPVg{OjxxYU6=
COLO205 Mn3pRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idg>? M3W3eFk3KGi{cx?= MmrpRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCFT1zPNlA2KGOnbHzzJIFnfGW{IEm2JIhzeyCkeTDDR2s5KGG|c3H5MEBKSzVyIE2gNE4zOTdizszNMi=> MmTIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2NUmyO|QoRjJ7NEW5Nlc1RC:jPh?=
MDA-MB-468 M2m0U2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5? MoDkPVYhcHK| NUTZWGZmSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvNE[4JINmdGy|IHHmeIVzKDl4IHjyd{BjgSCFQ1u4JIF{e2G7LDDJR|UxKD1iND64NFgh|ryPLh?= MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR3OUK3OEc,Ojl2NUmyO|Q9N2F-
COLO205 MXXJcohq[mm2aX;uJI9nKEOGS{SgbY4hcHWvYX6= MkD6NE4yKHSxIEGwJJVO M1\RfVI1KGi{cx?= M1vUd2lvcGmkaYTpc44hd2ZiQ1TLOEBqdiCqdX3hckBEV0yRMkC1JINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiC2b4ThcEBT[iCycn;0[YlvKGyndnXsJIF1KDBwMTD0c{AyOCC3TTDh[pRmeiB{NDDodpMh[nliaX3teY5w[myxdITpcochdWW2aH;k MmTiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2NUmyO|QoRjJ7NEW5Nlc1RC:jPh?=
COLO205 M1;XXWNmdGxiY4njcIUh[XO|YYm= MlW1eZAhfG9iMUCgeW0> M33hcVI1KGi{cx?= M{\KO2NmdGxiY4njcIUh[XK{ZYP0JIlvKGi3bXHuJGNQVE9{MEWgZ4VtdHNiYYPz[ZN{\WRiYYOgZYNkfW23bHH0bY9vKGG2IFeyM20heGijc3WgeZAhfG9iMUCgeW0h[W[2ZYKgNlQhcHK|IHL5JJBzd3CrZHn1cUBqd2SrZHWgd5RicW6rbnegZoF{\WRiRlHDV{BidmGueYPpdy=> MnrXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2NUmyO|QoRjJ7NEW5Nlc1RC:jPh?=
Assay
Methods Test Index PMID
Western blot p-Rb(S780) / Rb / p21 ; p-ERK / ERK / p-Akt / Akt / p-mTOR(S2448) / mTOR ; pRb(S795) / E2F1 / Cyclin A2 / Cyclin E2 26909611 27748766
Growth inhibition assay Cell viability 26909611
In vivo LY2835219 saturates BBB efflux with an unbound plasma IC50 of about 95 nM. The percent of dose in brain for LY2835219-MsOH is 0.5–3.9%. In both a subcutaneous and intracranial human glioblastoma model (U87MG), LY2835219-MsOH suppressed tumor growth in a dose-dependent manner both as a single agent, and in combination with temozolomide. [1]

Protocol (from reference)

Solubility (25°C)

In vitro

Water 100 mg/mL
(165.92 mM)
DMSO 83 mg/mL
(137.71 mM)
Ethanol '''24 mg/mL

In vivo

Add solvents to the product individually and in order
(Data is from Selleck tests instead of citations):
water
For best results, use promptly after mixing.

100mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 602.7
Formula

C27H32F2N8.CH4O3S

CAS No. 1231930-82-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCN1CCN(CC1)CC2=CN=C(C=C2)NC3=NC=C(C(=N3)C4=CC5=C(C(=C4)F)N=C(N5C(C)C)C)F.CS(=O)(=O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04967521 Not yet recruiting Drug: Abemaciclib|Drug: Placebo Advanced Dedifferentiated Liposarcoma Sarcoma Alliance for Research through Collaboration|Eli Lilly and Company September 2021 Phase 3
NCT04750928 Not yet recruiting Drug: Abemaciclib Neurofibromatosis 1 National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) September 7 2021 Phase 1|Phase 2
NCT04941274 Recruiting Drug: Abemaciclib Kaposi Sarcoma National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) September 7 2021 Phase 1|Phase 2
NCT04169074 Recruiting Drug: Abemaciclib|Drug: Abemaciclib plus nivolumab HNSCC University of Arizona June 16 2021 Phase 2
NCT04921904 Not yet recruiting Drug: Abemaciclib|Drug: Ramucirumab Metastatic Esophageal Adenocarcinoma|Metastatic Gastroesophageal Junction Adenocarcinoma Baylor Research Institute June 2021 Phase 1|Phase 2

(data from https://clinicaltrials.gov, updated on 2021-09-06)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

Question 1:
Is your product S7158 LY2835219 “mesylate salt form”?

Answer:
Our S7158 LY2835219 is mesylate salt form.

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