Adefovir Dipivoxil (GS 0840)

Catalog No.S1718

For research use only.

Adefovir Dipivoxil (GS 0840) is a reverse transcriptase inhibitor, used in the treatment of chronic hepatitis B virus (HBV).

Adefovir Dipivoxil (GS 0840) Chemical Structure

CAS No. 142340-99-6

Selleck's Adefovir Dipivoxil (GS 0840) has been cited by 5 Publications

Purity & Quality Control

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Biological Activity

Description Adefovir Dipivoxil (GS 0840) is a reverse transcriptase inhibitor, used in the treatment of chronic hepatitis B virus (HBV).
Targets
HBV RT [1]
In vitro

In vivo Adefovir Dipivoxil reduces Liver HBV DNA to <0.1 pg of viral DNA per mg of total DNA (pg/mg) in transgenic mice expressing hepatitis B virus. Adefovir Dipivoxil treatment also reduces serum HBV DNA to 3.5 log10 genomic equivalents (ge)/mL in transgenic mice expressing hepatitis B virus compared to 5.3 log10 ge/mL for the placebo control group. Adefovir Dipivoxil antiviral activity reaches near maximum viral reduction by day 10 in the liver and reaches an endpoint of liver virus inhibition at 1.0 mg/kg/day. [1]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 501.47
Formula

C20H32N5O8P

CAS No. 142340-99-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC(C)(C)C(=O)OCOP(=O)(COCCN1C=NC2=C(N=CN=C21)N)OCOC(=O)C(C)(C)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT00489151 Unknown status Drug: adefovir dipivoxil|Drug: lamivudine Hepatitis B Hospital Authority Hong Kong|The University of Hong Kong June 2005 Not Applicable
NCT00644761 Completed Drug: Adefovir Dipivoxil Hepatitis B Gilead Sciences February 2004 Phase 2
NCT00230477 Completed Drug: Hepsera|Drug: Hepsera and lamivudine Hepatitis B University of Washington|Gilead Sciences|GlaxoSmithKline April 2003 Phase 4
NCT00158717 Completed Drug: Hepsera Hepatitis B Gilead Sciences April 2003 --

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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