Name: Adefovir Dipivoxil (GS 0840)
Brand: Selleck Chemicals
SKU: S1718
Availability: InStock
Rating: 5 (6 reviews)

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Quality Control

Batch: Purity: 99.99%

99.99

Related Targets	Integrase Bacterial Antibiotics Anti-infection Fungal Antiviral COVID-19 Parasite HIV HCV Protease
Other Reverse Transcriptase Inhibitors	Dapivirine (TMC120) Fangchinoline 3'-Fluoro-3'-deoxythymidine (Alovudine) Salicylanilide Bifendate Ulonivirine Islatravir Lersivirine (UK-453061) 4-Chloro-2-(trifluoroacetyl)aniline hydrochloride

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (199.41 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 100 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	5.000mg/ml (9.97mM)	Taking the 1 mL working solution as an example, add 50 μL of 100 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	1.250mg/ml (2.49mM)	Taking the 1 mL working solution as an example, add 50 μL of 25 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

%

% Tween 80

% ddH₂O

% DMSO

+

%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	501.47	Formula	C₂₀H₃₂N₅O₈P	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	142340-99-6	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

Targets/IC₅₀/Ki	HBV RT
In vivo	Adefovir Dipivoxil (GS 0840) reduces Liver HBV DNA to <0.1 pg of viral DNA per mg of total DNA (pg/mg) in transgenic mice expressing hepatitis B virus. This compound also reduces serum HBV DNA to 3.5 log10 genomic equivalents (ge)/mL in the same model, compared to 5.3 log10 ge/mL for the placebo control group. Its antiviral activity reaches near maximum viral reduction by day 10 in the liver and achieves an endpoint of liver virus inhibition at 1.0 mg/kg/day.
References	[1] https://pubmed.ncbi.nlm.nih.gov/12076749/ [2] https://pubmed.ncbi.nlm.nih.gov/11796353/ [3] https://pubmed.ncbi.nlm.nih.gov/15388423/ [4] https://pubmed.ncbi.nlm.nih.gov/10718947/ [5] https://pubmed.ncbi.nlm.nih.gov/12865451/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2021-03-29)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT00973219	COMPLETED	Chronic Hepatitis B	Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)	2009-09
NCT02965859	UNKNOWN	Chronic Hepatitis B	Guangzhou Yipinhong Pharmaceutical CO.,LTD	2012-12	PHASE2
NCT02327416	UNKNOWN	Hepatitis B, Chronic	Tongji Hospital	2014-10	PHASE3
NCT00810524	UNKNOWN	Hepatitis B, Chronic	Sun Yat-sen University	2007-01	PHASE4
NCT02826070	UNKNOWN	Hepatitis B, Chronic	Nanfang Hospital, Southern Medical University	2015-04	PHASE4
NCT02327689	UNKNOWN	Hepatitis B, Chronic; Fibrosis	Asian-Pacific Alliance of Liver Disease, Beijing	2015-01	PHASE4

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Handling Instructions

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Adefovir Dipivoxil (GS 0840) Reverse Transcriptase inhibitor

Chemical Structure

Molecular Weight: 501.47