AS1269574

Catalog No.E0347

For research use only.

AS 1269574, a small-molecule G protein-coupled receptor 119 (GPR119) agonist, has an EC50 of 2.5 μM in HEK293 cells transiently expressing human GPR119 and enhances insulin secretion in the mouse pancreatic β-cell line MIN-6 only under high-glucose (16.8 mM) conditions.

AS1269574 Chemical Structure

CAS No. 330981-72-1

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Biological Activity

Description AS 1269574, a small-molecule G protein-coupled receptor 119 (GPR119) agonist, has an EC50 of 2.5 μM in HEK293 cells transiently expressing human GPR119 and enhances insulin secretion in the mouse pancreatic β-cell line MIN-6 only under high-glucose (16.8 mM) conditions.
Targets
IGF-1R [1] human GPR119 [1]
(in cAMP assay)
2.5 μM(EC50)

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 308.17
Formula

C13H14BrN3O

CAS No. 330981-72-1
Storage 3 years -20°C powder
2 years -80°C in solvent

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