Allylthiourea

For research use only.

Catalog No.S4017

Allylthiourea Chemical Structure

CAS No. 109-57-9

Allylthiourea is a metabolic inhibitor that selective inhibits ammonia oxidation.

Purity & Quality Control

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Biological Activity

Description Allylthiourea is a metabolic inhibitor that selective inhibits ammonia oxidation.
In vitro

Allylthiourea selectively inhibits ammonia oxidation at concentrations 8-80 μM. Allylthiourea (1 μM)inhibits ammonia oxidation by 80%. Complete inhibition is observed at an Allylthiourea concentration of 86 μM. [1] The inhibition of Allylthiourea on ammonia oxidation probably acts through chelating the copper of the ammonia monooxygenase active site. [2] Allylthiourea is able to produce soluble methane monooxygenase (sMMO) in the presence of copper. Addition of 25 μM Allylthiourea decreases intracellular copper by 48% in Methylosinus trichosporium OB3b, allowing sMMO production at Cu/biomass ratios normally not permitting sMMO synthesis, which achieves a plateau of 320 μmol naphthol formed per gram dry biomass per hour. [3]

Protocol

Solubility (25°C)

In vitro DMSO 23 mg/mL (197.96 mM)
Ethanol 23 mg/mL (197.96 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 116.18
Formula

C4H8N2S

CAS No. 109-57-9
Storage powder
in solvent
Synonyms N/A
Smiles C=CCNC(=S)N

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID