Home Immunology & Inflammation ROS inhibitor Allylthiourea

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Allylthiourea ROS inhibitor

Cat.No.S4017

Allylthiourea is a metabolic inhibitor that selective inhibits ammonia oxidation.
Allylthiourea ROS inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 116.18

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Quality Control

Batch: S401701 DMSO]23 mg/mL]false]Ethanol]23 mg/mL]false]Water]Insoluble]false Purity: 99.62%
99.62

Chemical Information, Storage & Stability

Molecular Weight 116.18 Formula

C4H8N2S

 Storage (From the date of receipt)
CAS No. 109-57-9 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles C=CCNC(=S)N

Solubility

In vitro
Batch:

DMSO : 23 mg/mL ( (197.96 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 23 mg/mL

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Mechanism of Action

In vitro
Allylthiourea selectively inhibits ammonia oxidation at concentrations 8-80 μM. This compound (1 μM) inhibits ammonia oxidation by 80%. Complete inhibition is observed at an Allylthiourea concentration of 86 μM. [1] The inhibition of this chemical on ammonia oxidation probably acts through chelating the copper of the ammonia monooxygenase active site. [2] It is able to produce soluble methane monooxygenase (sMMO) in the presence of copper. Addition of 25 μM this compound decreases intracellular copper by 48% in Methylosinus trichosporium OB3b, allowing sMMO production at Cu/biomass ratios normally not permitting sMMO synthesis, which achieves a plateau of 320 μmol naphthol formed per gram dry biomass per hour. [3]
References

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