(+)-beta-Cedrene is a natural product found in <i>Widdringtonia whytei</i>, <i>Helichrysum odoratissimum.</i>
||(+)-Bicuculline (d-Bicuculline) is a competitive antagonist of GABAA receptors with IC50 of 2 μM, also blocks Ca(2+)-activated potassium channels.
||(+)-Borneol is one of enantiomers of borneol which is a valuable medical material, senior aromatic spice, and chemical material and has been used in food and also folk medicine.
||(-)-Blebbistatin ((S)-(-)-Blebbistatin) is a cell-permeable inhibitor for non muscle myosin II ATPase with IC50 of ~2 μM in cell-free assays, does not inhibit myosin light chain kinase, inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly.
||(-)-Borneol (L-Borneol), one of enantiomers of borneol, has a camphoraceous and evident woody odor. (-)-Borneol has a highly efficacious positive modulating action at GABA receptor with an EC50 of 237 μM.
(-)-Butin is the S enantiomer of Butin that is a major biologically active flavonoid isolated from the heartwood of <i>Dalbergia odorifera</i>, with strong antioxidant, antiplatelet and anti-inflammatory activities.
||α-bisabolol is a small, plant-derived, oily sesquiterpene alcohol with some anti-inflammatory and even anti-microbial properties.
||1,2-Bis(2-iodoethoxy)ethane is a PEG-based PROTAC linker. 1,2-Bis(2-iodoethoxy)ethane is applicable to the synthesis of MT802 and SJF620 which are potent PROTAC BTK degraders with DC50 of 1 nM and 7.9 nM, respectively.
||1-BCP (Piperonylic acid piperidide) is a memory-enhancing agent that enhances AMPA-induced currents.
||1-Butanol occurs naturally as a minor product of the fermentation of sugars and other carbohydrates, and is present in many foods and beverages.
||2,3-Benzofuran is a mutagenic and carcinogenic compound.
||2,3-Butanediol (mixture of isomers)
||2,3-Butanediol (Dimethylene glycol, 2,3-Dihydroxybutane, Butan-2,3-diol, 2,3-Butylene glycol) is an important microbial metabolite and has been widely used in many fields such as food, medicine, chemical, and so on.
||2,3-Butanedione monoxime (BDM, Diacetyl monoxime, Diacetylmonoxime) is the well-characterized, low-affinity, non-competitive inhibitor of skeletal muscle myosin-II and inhibits skeletal and cardiac muscle contraction.
||2-(Benzyloxy)ethanol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||2-Benzoxazolinone (BOA, 2-Hydroxybenzoxazole), a well-known allelochemical with strong phytotoxicity, is a potential herbicidal candidate and probably functions via interfering with auxins or disrupting membrane integrity.
||2-Bromohexadecanoic acid (2-BP, 2-bromopalmitate) is a nonmetabolisable analogue of palmitate and acts as a palmitoylation inhibitor, which inhibits multiple palmitoyl-acyl transferase (PAT) activity towards MyrGCK(NBD) and FarnCNRas(NBD) with identical IC50s of approx. 4 µM. 2-Bromohexadecanoic acid can directly and irreversibly inhibit the palmitoyltransferase activity of all DHHC (Asp-His-His-Cys) proteins.
||3BDO, a butyrolactone derivative, could target FKBP1A and activate the mTOR signaling pathway. It inhibits autophagy in HUVECs. 3BDO inhibits oxLDL-induced apoptosis.
||3beta-hydroxy-delta5-cholenic acid is a monohydroxy bile acid of endogenous origin. It is found in biologic fluids beginning in fetal life.
||4,4'-Bis(4-aminophenoxy)biphenyl is a monomer for polyimide production.
||4-Biphenylacetic acid (BPA) is a potential non-steroidal anti-inflammatory agent and forms solid inclusion complex with β-cyclodextrin. Its interaction with quinolone antibacterial agents can induce functional blockade of the γ-aminobutyric acid receptors.
||4-Butylresorcinol (4-n-Butylresorcinol, Rucinol) is a potent inhibitor of tyrosinase and is used in cosmetics as a depigmenting agent.
||4BP-TQS is an allosteric agonist of α7 subunit-containing neuronal nicotinic acetylcholine receptors (nAChRs).
5-BDBD is a potent P2X4R selective antagonist with an IC50 of 0.75 μM when applied for 2 min prior and during ATP stimulation.
||5-Boc-amino-pentanoic acid (Boc-5-aminovaleric acid, Boc-NH-C4-acid, Boc-5-Ava-OH) is a PROTAC linker that belongs to a Alkyl/ether linker. Boc-NH-C4-acid is applicable to the synthesis of PROTAC1, and specifically degrades EED, EZH2, and SUZ12 in the PRC2 Complex.
||5-Bromocytosine can be used in the synthesis of cross-link products under anaerobic and aerobic conditions.
||6-Benzoylheteratisine is a naturally occurring antagonist of the Na+ channel activator aconitine.
||6-Benzylaminopurine is a first-generation synthetic cytokinin which could regulate the activities of the antioxidant defense system of plants.Its treatment elicits plant growth and development.
||6-Biopterin ( L-Biopterin, L-Erythro-Biopterin) is a natural product that has been considered as a growth factor for some insects.
||6-Bromo-2-hydroxy-3-methoxybenzaldehyde is a bromobenzaldehyde derivative that participates in the synthesis of (±)-norannuradhapurine. 6-Bromo-2-hydroxy-3-methoxybenzaldehyde is an IRE-1α inhibitor with an IC50 of 0.08 μM.
7beta-Hydroxybufalin is a kind of steroids derived from the glandular body of Bufo bufo gargarizans Cantor.
||7-bromoindirubin-3-oxime (7BIO), an indirubin derivative derived from indirubin-3-oxime, possesses inhibitory effects against cyclin-dependent kinase-5 (CDK5) and glycogen synthase kinase-3β (GSK3β), also potently inhibits Aβ oligomer-induced neuroinflammation, synaptic impairments, tau hyper-phosphorylation, and activation of astrocytes and microglia.
||8-bromo-cAMP (8-Br-Camp) is a cell permeable analog of cAMP that activates cyclic-AMP-dependent protein kinase with a Ka value of 0.05 μM; and a PKA activator.
||b-AP15 (NSC687852) is a deubiquitinases inhibitor for 19S proteasomes activity of Ub-AMC cleavage with IC50 of 2.1 μM.
||B-Raf IN 1
||B-Raf IN 1 is an inhibitor of Raf wih IC50 values of 24 nM and 25 nM for B-Raf and C-Raf respectively. It is selective over 13 other kinases, including PKCα, IKKβ, and PI3Kα.
||B-Raf inhibitor 1 (Compound 13) dihydrochloride
||B-Raf inhibitor 1 (Compound 13) is a type IIA Raf inhibitor which bind to the DFG-out conformation with ki of 1 nM,1 nM,and 0.3 nM for B-Raf(WT), B-Raf(V600E) and C-Raf, respectively.
||B355252 is a neuroprotective agent potentiating nerve growth factor (NGF)-induced neurite outgrowth. B355252 protects against cell death caused by glutamate-evoked oxidative stress.
||Baccatin Ⅲ is a polycyclic diterpene which can be used for the semi-synthesis of paclitaxel and analogs. It exhibits immunomodulatory and anticancer chemotherapeutic activities.
||Bacitracin is a mixture of related cyclic polypeptides produced by organisms of the licheniformis group of Bacillus subtilis var Tracy, which disrupts both gram positive and gram negative bacteria by interfering with cell wall and peptidoglycan synthesis.
||Bacitracin is an antibiotic that interferes with the dephosphorylation of C55-isoprenyl pyrophosphate, a membrane carrier molecule that transports the building-blocks of the peptidoglycan bacterial cell wall outside of the inner membrane. It inhibits cleavage of Tyr from Met-enkephalin with IC50 of 10 μM.
||Baclofen is a gamma-amino-butyric acid (GABA) derivative used as a skeletal muscle relaxant and central nervous system depressant. It activates GABA receptors, specifically the GABAB receptors.
||Bacopa monniera Extract
Bacopasaponin C is a natural glycoside isolated from Bacopa monniera and has anti-tumor and anti-Leishmania activities.
Bacopaside II is a natural product of medicinal plant Bacopa monnieri, which blocks Aquaporin-1 (AQP1) water channel and hinders the migration of cells expressing AQP1, and also induces cell cycle arrest and apoptosis.
||Bafetinib (INNO-406, NS-187) is a potent and selective dual Bcr-Abl/Lyn inhibitor with IC50 of 5.8 nM/19 nM in cell-free assays, does not inhibit the phosphorylation of the T315I mutant and is less potent to PDGFR and c-Kit. Phase 2.
||Bafilomycin A1 (Baf-A1)
||Bafilomycin A1(Baf-A1) is a vacuolar H+-ATPase inhibitor with IC50 of 0.44 nM. Bafilomycin A1 is found to inhibit autophagy while induces apoptosis.
||BAI1 is a direct allosteric inhibitor of BAX with a dissociation constant (Kd) of 15.0 ± 4 μM.
||Baicalein is a CYP2C9 and prolyl endopeptidase inhibitor.
||Baicalin (NSC-661431) is a known prolyl endopeptidase inhibitor and affects the GABA receptors.
||Bakkenolide A (Fukinanolid), extracted from Petasites tricholobus, has been suggested to against cancer and display protective effects on inflammatory cytokines formation.
||Bakuchiol ((S)-(+)-Bakuchiol) is a meroterpene phenol abundant in seeds and leaves of the plant Psoralea corylifolia. It has anti-inflammatory and antimicrobial activities.
||Balicatib (AAE-581) is a potent and selective inhibitor of the osteoclastic enzyme cathepsin K.
Balixafortide (POL6326) is an orally bioavailable peptidic CXC chemokine receptor 4 (CXCR4) antagonist.
||Balofloxacin (Q-35) is a quinolone antibiotic, inhibiting the synthesis of bacterial DNA by interference with the enqyme DNA gyrase.
||Balofloxacin Dihydrate is an orally active fluoroquinolone antibiotic.
||Baloxavir (Baloxavir acid, S-033447) is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor with an IC50 of 2.5 nM. BXA inhibits viral RNA transcription via selective inhibition of CEN activity.
||Baloxavir marboxil, a cap-endonuclease inhibitor, is an antiviral drug.
||Balsalazide (Colazal, Giazo), an aminosalicylate and oral prodrug, is enzymatically cleaved in the colon to produce the anti-inflammatory agent mesalazine. Balsalazide suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway.
||Balsalazide Disodium is the disodium salt form of balsalazide, an aminosalicylate and oral prodrug that is enzymatically cleaved in the colon to produce the anti-inflammatory agent mesalazine. Balsalazide Disodium suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway.
||Balsam Pear Extract
||Balsam Pear Powder
||BAM(8-22), a proteolytically cleaved product of proenkephalin A, is a potent activator of Mas-related G-protein-coupled receptors (Mrgprs), MrgprC11 and hMrgprX1, and induces scratching in mice in an Mrgpr-dependent manner.
||BAM 15 is a novel mitochondrial protonophore uncoupler capable of protecting mammals from acute renal ischemic-reperfusion injury and cold-induced microtubule damage. BAM 15 is also a potent AMPK activator. BAM 15 attenuates transportation-induced apoptosis in iPS-differentiated retinal tissue.
||BAMB-4 (ITPKA-IN-C14) is a new type of membrane permeable ITPKA inhibitor, and IC50 is 37 μM in the Kinase ADP-Glo assay.
||Bamboo Sap Extract
||Bamboo Shaving Extract
||Bambuterol HCl is a potent β-adrenoceptor agonist, used in the treatment of asthma.
||Baohuoside I (Icariside II) is a flavonoid isolated from Epimedium koreanum Nakai with anti-inflammatory and anti-cancer activities. It may exert cytotoxic effect via the ROS/MAPK pathway.
||BAPTA tetrapotassium salt
||BAPTA tetrapotassium salt (BAPTA tetrapotassium, Bapta-am) is a non-permeable, selective extracellular calcium chelator, with 105-fold greater affinity for Ca2+ than Mg2+, which is a valuable tool to study the role of calcium in cell signaling.
||BAPTA-AM is a selective, membrane-permeable calcium chelator.
||BAR501 is a potent and selective G protein-coupled bile acid receptor 1 (GPBAR1, GPCR19, TGR5) agonist that effectively transactivates GPBAR1 in HEK293 cells overexpressing a CRE along with GPBAR1 with EC50 of 1 μM.
||BAR502 is a dual agonist with IC50 of 2 μM and 0.4 μM for FXR and GPBAR1, respectively.
||Defosbarasertib (AZD1152-HQPA, AZD2811, INH-34, Barasertib-HQPA) is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay, ~3700 fold more selective for Aurora B over Aurora A. Phase 1.
||Bardoxolone (CDDO, RTA 401), acts by releasing Nrf2 from KEAP1,is a highly potent activator of Nrf2 that induce programmed cell death (apoptosis) in cancer cells.
||Bardoxolone Methyl (RTA 402, TP-155, NSC 713200, CDDO Methyl Ester, CDDO-Me) is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities; Also a potent Nrf2 activator and nuclear factor-κB (NF-κB) inhibitor. Bardoxolone Methyl abrogates ferroptosis. Bardoxolone methyl induces apoptosis and autophagy in cancer cells.
||Baricitinib (LY3009104, INCB028050) is a selective JAK1 and JAK2 inhibitor with IC50 of 5.9 nM and 5.7 nM in cell-free assays, ~70 and ~10-fold selective versus JAK3 and Tyk2, no inhibition to c-Met and Chk2. Baricitinib is found to reduce or interrupt the passage of the virus into target cells and is used in the treatment research for COVID-19. Phase 3.
||Baricitinib phosphate (INCB-028050, LY-3009104) is a selective JAK1 and JAK2 inhibitor with IC50 of 5.9 nM and 5.7 nM, ~70 and ~10-fold selective versus JAK3 and Tyk2, no inhibition to c-Met and Chk2. Baricitinib is found to reduce or interrupt the passage of the virus into target cells and is used in the treatment research for COVID-19.
||Barley grass Extract
||Barnidipine (Libradin, Mepirodipine, Vasexten, YM-09730-5, Cyress, Hypoca, Oldeca) is an antihypertensive drug that belongs to the dihydropyridine (DHP) group of calcium antagonist (CaA) with Ki of 0.21 nM for [3H]nitrendipine binding sites.
||Basella rubra Extract
Bassiatin ((3S,6R)-Lateritin), isolated from the cultured broth of Beauveria bassiana, is a new platelet aggregation inhibitor. Bassiatin inhibits ADP-induced aggregation of rabbit platelets with the IC50 of 0.19 μM.
||Batefenterol (GSK961081, TD-5959) is both a muscarinic receptor antagonist and a β2-adrenoceptor agonist with Ki of 1.4 nM, 1.3 nM and 3.7 nM for hM2, hM3 muscarinic receptors and hβ2-adrenoceptor, respectively.
||Batimastat (BB-94) is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3 with IC50 of 3 nM, 4 nM, 4 nM, 6 nM and 20 nM, respectively. Also inhibits the activitity of other metalloproteases, such as ADAM17.
||Batyl alcohol (Batilol, Stearyl monoglyceride, 1-O-Octadecylglycerol, Batilolum), isolated from shark liver oil, is also present in yellow bone marrow of animals and has been described as an inflammatory agent.
||Bauhinia Variegata Extract
Bavachalcone is a major bioactive compounds isolated from Psoralea corylifolia L.Bavachalcone has been widely used as antibiotic or anticancer agent.
||Bavachin (Corylifolin) is a phytoestrogen purified from natural herbal plants such as Psoralea corylifolia. It acts as a weak phytoestrogen by binding and activating the ER.
||Bavachinin (7-O-Methylbavachin) is a novel natural pan-PPAR agonist from the fruit of the traditional Chinese glucose-lowering herb malaytea scurfpea. It shows stronger activities with PPAR-γ than with PPAR-α and PPAR-β/δ (EC50 = 0.74 μmol/l, 4.00 μmol/l and 8.07 μmol/l in 293T cells, respectively).
||Bavdegalutamide (ARV-110) is an orally bioavailable, specific androgen receptor (AR) PROTAC degrader that leads to ubiquitination and degradation of AR. ARV-110 completely degrades androgen receptor (AR) in all cell lines tested with DC50 of < 1 nM. ARV-110 can be used for the research of prostate cancer.
||BAW2881 (NVP-BAW2881) is a novel vascular endothelial growth factor (VEGF) receptor tyrosine-kinase inhibitor that potently inhibits VEGFR1-3 at 1.0-4.3 nanomolar (nM) concentrations and inhibits PDGFRβ, c-Kit, and RET (c-RET) at 45-72 nM concentrations.
||BAY 11-7082 (BAY 11-7821) is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM in tumor cells. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 with IC50 of 0.19 μM and 0.96 μM, respectively. BAY 11-7082 induces apoptosis and S phase arrest in gastric cancer cells.
||BAY 11-7085 (Bay 11-7083) is an irreversible inhibitor of TNFα-induced IκBα phosphorylation with IC50 of 10 μM.
||BAY 1217389 is an orally bioavailable, selective inhibitor of the serine/threonine kinase monopolar spindle 1 (Mps1) with IC50 values below 10 nmol/L while showing an excellent selectivity profile.
||BAY1251152 is a potent PTEFb/CDK9 inhibitor with an IC50 value of 3 nM for CDK9 and an at least 50-fold selectivity against other CDKs in enzymatic assays. BAY1251152 binds to and blocks the phosphorylation and kinase activity of CDK9, thereby preventing PTEFb-mediated activation of RNA Pol II and leading to the inhibition of gene transcription of various anti-apoptotic proteins.
||BAY-1436032 is a highly selective, potent and orally available inhibitor of mutant Isocitrate Dehydrogenase 1 (mIDH1). It is a double-digit nanomolar and selective pan-inhibitor of the enzymatic activity of various IDH1-R132X mutants in vitro and displays potent inhibition of 2-HG release (nanomolar range) in patient derived and engineered cell lines expressing different IDH1 mutants.
||BAY 2416964 (compound 192) is a potent and orally active antagonist of aryl hydrocarbon receptor (AhR) with IC50 of 341 nM. BAY 2416964 has the potential in the treatment of solid tumors.
||BAY 2666605 is an orally active phosphodiesterase 3A (PDE3A) and phosphodiesterase 3B (PDE3B) inhibitor with IC50s of 87 nM and 50 nM, respectively.
||BAY 41-2272 is a direct and NO-independent soluble guanylate cyclase (sGC) stimulator.
||Bay 41-4109 racemate
||BAY 41-4109 racemate (BAY41-4109 Racemic) is a mixture of R-isomer of BAY 41-4109 and S-isomer of BAY 41-4109. BAY 41-4109 an antiviral compound that inhibits human hepatitis B virus (HBV) with IC50 of 53 nM.
||Bay 59-3074 is a selective cannabinoid CB1/CB2 receptor partial agonist with Ki of 55.4 nM, 48.3 nM and 45.5 nM at rat and human CB1 and human CB2 receptors, respectively. Bay 59-3074 displays analgesic properties.
||BAY 87-2243 is a potent and selective hypoxia-inducible factor-1 (HIF-1) inhibitor. BAY 87-2243 inhibits mitochondrial complex I activity, thus triggering a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis. BAY 87-2243 exerts antitumor activity. Phase 1.
||Bay K 8644
||Bay K 8644 is a potent, selective activator of L-type Ca2+ channel with IC50 of 17.3 nM.
||BAY-1816032 is a potent and oral available inhibitor of budding uninhibited by benzimidazoles 1 (BUB1) kinase with IC50 of 6.1 nM for recombinant catalytic domain of human BUB1. BAY-1816032 has antitumor activity.
||BAY-218 is a potent and selective small-molecule AhR inhibitor, inhibiting AhR nuclear translocation, dioxin response element (DRE)-luciferase reporter expression and AhR-regulated target gene expression induced by both exogenous and endogenous AhR ligands.
||BAY-293 selectively inhibits the KRAS-SOS1 interaction with an IC50 of 21 nM.
||BAY-3827 is a potent AMPK inhibitor which inhibits AMPK kinase activity with IC50 values of 1.4 nM at a low, 10 μM ATP concentration and 15 nM at a high, 2 mM ATP concentration.
||BAY-474 is an inhibitor of tyrosine-protein kinase c-Met and can act as an epigenetics probe.
||BAY-545 is an A2B adenosine receptor antagonist with ic50 of 59 nM.
||BAY-61-3606 is a potent and selective inhibitor of Syk kinase (Ki = 7.5 nM). BAY-61-3606 induces cell cycle arrest and apoptosis.
||BAY-8002 is a novel MCT1 inhibitor and potently suppress bidirectional lactate transport. BAY-8002 significantly increases intratumor lactate levels and transiently modulates pyruvate levels.
||BAY-876 is a potent and selective GLUT1 inhibitor (IC50=0.002 μM) with a selectivity factor of >100 against GLUT2, GLUT3, and GLUT4.
||BAY-885 is a highly potent and selective ERK5 inhibitor.
||BAY-985 is a potent and highly selective TBK1/IKKε inhibitor. BAY-985 shows high potency toward TBK1 (IC50 = 2 nM, low ATP assay; 30 nM, high ATP assay) and IKKε(IC50 = 2 nM), as well as high potency in the mechanistic pIRF3 assay (IC50 = 74 nM), and an antiproliferative effect on SK-MEL-2 cells (IC50 = 900 nM).
||BAY1082439 is an orally bioavailable and selective inhibitor of PI3Kα/β/δ with anti-cancer activity. BAY1082439 also inhibits mutated forms of PIK3CA.
||BAY 1125976 is a selective allosteric AKT1/2 inhibitor,exhibits high efficacy on AKT signaling-dependent tumor growth in mouse models. BAY1125976 inhibits the activity of AKT1 (IC50 = 5.2 nM at 10 µM ATP and 44 nM at 2 mM ATP) and AKT2 (IC50 = 18 nM at 10 µM ATP and 36 nM at 2 mM ATP) very potently.Whereas BAY1125976 is almost inactive on AKT3 (IC50 = 427 nM at 10 µM ATP).
Bayogenin is an alfalfa saponins, which has certain inhibitory effect on glycogen phosphorylase.
||BAZ1A-IN-1 is a potent inhibitor of BAZ1A (bromodomain-containing protein), exerting a Kd value of 0.52 μM against BAZ1A bromodomain, shows good anti-viability activity against cancer cell lines expressing a high level of BAZ1A, but weak or no activity against cancer cells with a low expression level of BAZ1A.
||Bazedoxifene (TSE-424) acetate
||Bazedoxifene Acetate (WAY-140424, TSE-424) is a third generation selective estrogen receptor modulator (SERM).
||Bazedoxifene (WAY-140424) HCl
||Bazedoxifene HCl (WAY-140424, TSE-424) is a novel, non-steroidal, indole-based estrogen receptor modulator (SERM) binding to both ERα and ERβ with IC50 of 23 nM and 89 nM, respectively.
||BC-1215 is an inhibitor of F-box protein 3 (Fbxo3, a ubiquitin E3 ligase component) with IC50 of 0.9 μg/mL and LC50 of 87 μg/ml for IL-1β release. BC-1215 inhibits the Fbxo3-TRAF activation pathway by destabilizing TRAF1-6.
||BC-LI-0186 is a selective blocker of Leucyl-tRNA synthetase (LRS, LeuRS) and Ras-related GTP-binding protein D (RagD) interaction (LRS-RagD interaction) (IC50 = 46.11 nM) by competing against RagD for LRS VC domain binding (KD = 42.1 nM), thereby inhibiting lysosomal localization of LRS and mTORC1 activity. It also effectively suppresses the activity of cancer-associated mTOR mutants and the growth of rapamycin-resistant cancer cells.
||BC1618 is an orally active Fbxo48 inhibitor that stimulates adenosine monophosphate (AMP)-activated protein kinase (Ampk)-dependent signaling. BC1618 promotes mitochondrial fission, facilitates autophagy and improves hepatic insulin sensitivity.
||BCATc Inhibitor 2
||BCATc Inhibitor 2 is a selective branched-chain aminotransferase (BCAT) inhibitor for research of neurodegenerative diseases. The IC50s of BCATc Inhibitor 2 are 0.2 μM, 0.8 μM and 3.0 μM for rat cytosolic isoenzyme rBCATc, human cytosolic isoenzyme hBCATc and rat mitochondrial isoenzyme rBCATm, respectively.
||BCH (2-Aminobicyclo-(2,2,1)-heptane-2-carboxylic acid, LAT1-IN-1) is a selective and competitive inhibitor of system L amino acid transporter 1 (LAT1). BCH (LAT1-IN-1) induces apoptosis in cancer cells.
||BCH001 is a specific PAPD5 inhibitor that restores telomerase activity and telomere length in dyskeratosis congenita (DC) patient induced pluripotent stem cells. PAPD5 is a noncanonical poly(A) polymerase with an unusual RNA-binding motif.
||BCI ((E)-BCI, compound 1) is an allosteric dual specificity phosphatase (DUSP) inhibitor with EC50 of 13.3 μM and 8.0 μM in cells for DUSP6 and DUSP1, respectively.
||BCI-121 is a potent inhibitor of SMYD3 that impairs the proliferation of many kinds of cancer cells.
||BCL6-IN-7 (BCL6 inhibitor 7) is a potent inhibitor of BCL6 protein-protein interaction.
||BCTC is an orally effective and highly potent vanilloid receptor 1 (VR1/TRPV1) antagonist. BCTC inhibits capsaicin-induced and acid-induced activation of rat VR1 with IC50 of 35 nM and 6.0 nM, respectivley. BCTC exhibits anti-tumor activity.
||BD-1047 dihydrobromide (HBr) is a selective functional antagonist of sigma-1 (σ1) receptor, shows antipsychotic activity in animal models predictive of efficacy in schizophrenia.
||BD1063 2HCL (BD1063 dihydrochloride) is a potent and selective sigma-1 receptor (σ1R) antagonist with Ki of 4.43 nM.
||BD750 is an immunosuppressant and a dual inhibitor of JAK3 and STAT5 that inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation with IC50 of 1.5 μM and 1.1 μM for mouse and human T-cell proliferation, respectively.
||BDP5290 is a potent dual inhibitor of ROCK and MRCK with IC50 of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.
||BDTX-189 is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations with Kd of 0.2 nM, 0.76 nM, 13 nM and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively. BDTX-189 exhibits anticancer activity.
||Bean Sprout Extract
||Beautiful millettia root Extract
||BEBT-908 (CUDC-908, PI3Kα inhibitor 1, MDK9521, PI3Kα-IN-243) is a potent selective inhibitor of PI3Kα with IC50 < 0.1 μM. BEBT-908 also inhibits HDAC with IC50 ≤ 1 μM.
||BEC HCl is a slow-binding, and competitive arginase inhibitor with Ki of 0.31 μM (pH7.5) and 0.4-0.6 μM for Arginase II and rat Arginase I, respectively.
||Beclamide (N-Benzyl-3-chloropropionamide, beta-chlorpropionamide) exhibits sedative and anticonvulsant properties.
||Beclomethasone dipropionate is a potent glucocorticoid steroid used for the treatment of rhinitis and sinusitis.
||Bedaquiline (TMC-207, R207910), a diarylquinoline, binds to subunit c of mycobacterial ATP synthase and inhibits its activity. It is highly selective for mycobacterial ATP synthase enzyme compared to homologous eukaryotic enzyme (Selectivity Index >20 000).
||Bedaquiline fumarate (TMC-207), an oral diarylquinoline, is a bactericidal antimycobacterial drug. It is a proton-translocating ATP synthetase inhibitor.
||Bee flower Extract
||Bee Pollen Extract
||Beef tendon grass Extract
||Behenic Acid (docosanoic acid) is a long-chain saturated fatty acid that exists naturally as a triglyceride in canola. It act as a lubricant that helps restore the skin's natural oils and improve overall levels of hydration.
||Belamcandae Rhizoma Extract
||Belamcandae Rhizoma Extract is extracted from dry roots of Belamcanda chinensis (L.) DC.. Belamcanda chinensis is mainly used to treat sore throat, bronchitis, and chronic tracheitis. Isoflavonoids, including irigenin, isolated from the rhizome of Belamcanda chinensis have been suggested to possess not only antioxidative and anti-inflammatory, but also antitumor activities.
||Belinostat (PXD101, NSC726630, PX-105684) is a novel HDAC inhibitor with IC50 of 27 nM in a cell-free assay, with activity demonstrated in cisplatin-resistant tumors. Belinostat (PXD101) induces autophagy.
||"Belizatinib (TSR-011) is a potent inhibitor of ALK (IC50=0.7 nM) and tropomyosin receptor kinase (TRK) (IC50 values less than 3 nM for TRK A, B, and C).
Bellidifolin ameliorates Isoprenaline-Induced myocardial fibrosis by regulating TGF-β1/Smads and p38 signaling and preventing NR4A1 cytoplasmic localization.
||Belnacasan (VX-765) is a potent and selective inhibitor of caspase-1 with Ki of 0.8 nM in a cell-free assay. Phase 2.
||Belotecan (CKD-602) hydrochloride
||Belotecan (CKD-602) is a potent DNA topoisomerase I inhibitor that exerts a clinical anticancer effect on various types of tumor.
||Belumosudil (KD025, SLx-2119) is an orally available, and selective ROCK2 inhibitor with IC50 and Ki of 60 nM and 41 nM, respectively. Phase 2.
||Belvarafenib (GDC5573, HM95573, RG6185) is a selective and orally bioavailable pan-RAF kinase inhibitor with IC50 values of 41 nM, 7 nM and 2 nM for BRAF WT, BRAF(V600E) and CRAF kinases, respectively.
||Bemcentinib (R428, BGB324) is an inhibitor of Axl with IC50 of 14 nM, >100-fold selective for Axl versus Abl. Selectivty for Axl is also greater than Mer and Tyro3 (50-to-100- fold more selective) and InsR, EGFR, HER2, and PDGFRβ (100- fold more selective).
||Bemegride is a central nervous system stimulant and antidote for barbiturate poisoning.
||Bemnifosbuvir Hemisulfate (AT-527)
Bemnifosbuvir Hemisulfate (AT-527, RG-6422, RO 7496998) is a hemi-sulfate salt of AT-511. AT-511 is a potent inhibitor of SARS-CoV-2 with an EC90 of 0.47 μM.
||Benactyzine hydrochloride is a centrally acting muscarinic antagonist. It is used as an antidepressant in the treatment of depression and associated anxiety.
||Benazepril is used to treat high blood pressure (hypertension), congestive heart failure, and chronic renal failure. Benazepril is converted into its active form benazeprilat, a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor.
||Benazepril HCl (CGS 14824A) is a novel angiotensin I converting enzyme inhibitor, used primarily in treatment of hypertension.
||Bendamustine (SDX105) is a nitrogen mustard drug used in the treatment of chronic lymphocytic leukemia (CLL), multiple myeloma, and non-Hodgkin's lymphoma.
||Bendamustine (SDX105) HCl
||Bendamustine (SDX-105, Cytostasane) HCl is a DNA-damaging agent with IC50 of 50 μM in cell-free assay.
||Bendazac (bendazolic acid, AF-983) is a non-steroidal anti-inflammatory drug that delays the cataractogenic process. It may act by preventing protein denaturation.
||Bendazac L-lysine has a protective effect against lens protein denaturation both in vitro and in vivo. It is also a nonsteroidal anti-inflammatory drug (NSAID) used for joint and muscular pain.
||Bendazol (2-Benzylbenzimidazole, Dibazol, Dibazole, Bendazole, Tromasedan) is a hypotensive drug that enhances NO synthase activity in renal glomeruli and collecting tubules. Bendazol inhibits the progression of form-deprivation myopia (FDM) and suppresses the upregulation of HIF-1α.
||Benfotiamine (S-Benzoylthiamine O-monophosphate) is a synthetic S-acyl derivative of thiamine (vitamin B1) and has been investigated for the treatment and prevention of Diabetic Nephropathy and Diabetes Mellitus, Type 2. Benfotiamine suppresses oxidative stress-induced NF-κB activation and prevents the bacterial endotoxin-induced inflammation.
||Benidipine HCl (KW-3049) is a hydrochloride salt form of benidipine which is a dihydropyridine calcium channel blocker.
||Benorylate (Benorilate, Benoral, Benortan) is the esterification product of paracetamol and acetylsalicylic acid with anti-inflammatory, analgesic and antipyretic properties.
||Benproperine phosphate (Blascorid, Pirexyl), a cough suppressant, is an orally active, potent actin-related protein 2/3 complex subunit 2 (ARPC2) inhibitor. Benproperine phosphate attenuates the actin polymerization rate of action polymerization nucleation by impairing Arp2/3 function. Benproperine phosphate suppresses cancer cell migration and tumor metastasis.
||Benpyrine racemate ((Rac)-Benpyrine) is a potent, highly specific and orally active inhibitor of TNF-α and attenuates TNF-α-induced inflammation, thereby reducing liver and lung injury.
||Benserazide HCl (Ro-4-4602) is a peripherally-acting aromatic L-amino acid decarboxylase (AAAD) or DOPA decarboxylase inhibitor.
||Bentamapimod (AS602801) is a novel, orally active JNK inhibitor with IC50 values of 80 nM, 90 nM and 230 nM for JNK1, JNK2 and JNK3 respectively.
||Bentiromide is a peptide which is broken down in the pancreas by chymotrypsin. The bentiromide test is a test of pancreatic exocrine function.
||Benzalkonium chloride, a detergent and preservative found in health care and household products, is an established irritant.
||Benzamide, a derivative of benzoic acid, is an inhibitor of poly(ADP-ribose) polymerase with an IC50 of 3.3 μM.
||Benzamil (Benzylamiloride), an analogue of amiloride, is a Na+/Ca2+ exhanger (NCX) inhibitor with IC50 of ~ 100 nM and an epithelial sodium channel (ENaC) blocker. Benzamil inhibits TRPP3-mediated Ca2+-activated currents with IC50 of 1.1 μM.
||Benzathine penicilline (Benzathine penicillin G) is an antibiotic useful for the treatment of a number of bacterial infections.
||Benzbromarone is a CYP2C9 inhibitor, it binds to CYP2C9 with Ki value of 19.3 nM.
||Benzenepentanol undergoes oxidation in the presence of ceric ammonium nitrate to yield 2-benzyltetrahydrofuran.
||Benzenesulfonamide (Benzenesulphonamide, Benzosulfonamide, Phenyl sulfonamide, Benzene sulfonamide) ia an inhibitor of carbonic anhydrases.
||Benzethonium chloride is a potent inhibitor of nAChRs, it inhibits α4β2 nAChRs and α7 nAChRs with IC50 of 49 nM and 122 nM, respectively.
||Benzetimide (R4929) hydrochloride is an antagonist of muscarinic acetylcholine receptor.
||Benznidazole (Radanil) is a nitroimidazole derivative having an antiprotozoal activity by interfering with parasite protein biosynthesis, influencing cytokines production and stimulating host phagocytosis.
Benzo(a)-1,3-benzodioxolo(4,5-g)quinolizinium, 8,9-dimethoxy-6-methyl- is a natural product found in <i>Fumaria capreolata</i>, or <i>Fumaria indica</i>.
||Benzocaine is the ethyl ester of p-aminobenzoic acid (PABA), it is a local anesthetic commonly used as a topical pain reliever or in cough drops.
||Benzocaine hydrochloride (Ethyl 4-aminobenzoate, Ethyl p-aminobenzoate) is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.
||Benzoic acid (FEMA 2131) is a colorless crystalline solid and a simple aromatic carboxylic acid, used as a food preservative.
||Benzaldehyde (Benzenecarboxaldehyde, Phenylmethanal, Benzoic) is an organic compound that is frequently used in industry for chemical synthesis.
||Benzophenone (Diphenyl ketone, Benzoylbenzene) filters out both UVA and UVB rays and is widely used in a great variety of sunscreens and personal care products.
||Benzoylaconine (Isaconitine, Pikraconitin) is an alkaloid derived from the Chinese traditional medicine Radix Aconiti Lateralis Preparata (Fuzi). Benzoylaconitine inhibits production of IL-6 and IL-8 via MAPK, Akt, NF-κB signaling in IL-1β-induced human synovial cells.
Benzoylalbiflorin is a monoterpenoid isolated from Radix Paeoniae Alba, which is a traditional Chinese medicine used for the research of rheumatoid arthritis, inflammation, amenorrhea, epistaxis, abdominal pain, and other symptoms.
||Benzoyleneurea (2,4-Dihydroxyquinazoline, Quinazolinedione, Quinazoline-2,4-diol) scaffold is used in the synthesis of novel protein geranylgeranyltransferase-I inhibitors. Benzoyleneurea possesses anti-bacterial activity.
||Benzoylhypaconine (Benzoylhypacoitine) is a monoester Aconitum alkaloid, the main pharmacologic and toxic component.
||Benzoylmesaconine (Mesaconine 14-benzoate) is a main Aconitum alkaloid isolated from several Aconitum species with potent pharmacological activities, such as analgesia and anti-inflammation.
Benzoyloxypaeoniflorin, isolated from the roots of <i>Paeonia suffruticosa</i>, is a tyrosinase inhibitor against mushroom tyrosinase with IC50 of 0.453 mM, also is NF-κB Inhibitor and contributes to blood circulation improvement through its inhibitory effect on both platelet aggregation and blood coagulation.
||Benztropine is a dopamine transporter (DAT) inhibitor with IC50 of 118 nM.
||Benzydamine HCl (AF864) is a topical nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, antipyretic and local anesthetic activity.
||Benzyl acetate (Acetic acid benzyl ester, Benzyl ethanoate, Phenylmethyl), usually found in alcoholic beverages, is a flavouring agent.
||Benzyl alcohol (Phenylmethanol, Benzenemethanol, Phenylcarbinol, Benzoyl alcohol) is used as a local anesthetic. Also, it is used in the manufacture of other benzyl compounds, as a pharmaceutic aid, and in perfumery and flavoring.
||Benzyl benzoate (Ascabiol, Novoscabin, Scabitox, Benzoic acid benzyl ester) is one of the older preparations used to treat scabies. Scabies is a skin infection caused by the mite sarcoptes scabiei.
||Benzyl cinnamate (Cinnamein, Benzylcinnamoate, Benzyl 3-phenylpropenoate, Cinnamic acid benzyl ester), a flavouring agent isolated from various plant species, is used in heavy oriental perfumes and as a fixative.
||Benzyl isothiocyanate (BITC, Benzoylthiocarbimide, Isothiocyanic Acid Benzoyl Ester) is an isothiocyanate originally found in cruciferous vegetables that exhibits immunomodulatory, anti-parasitic, antibiotic, antioxidative, anti-atherosclerotic, anti-angiogenic, anti-metastatic, anticancer chemotherapeutic, and chemopreventive activities.
||Benzylacetone (4-Phenyl-2-butanone, Methyl 2-phenylethyl ketone) is an attractant compound in flowers. Benzylacetone exhibits potent and reversible antityrosinase (mushroom) activity, with IC50s of 2.8 mM and 0.6 mM for monophenolase and diphenolase, respectively.
||Benzamil hydrochloride is a potent and specific blocker of sodium channel (ENaC).
||Benzylcetyldimethylammonium chloride hydrate
||Benzylcetyldimethylammonium chloride hydrate is a chemical.
||Benzyldimethylstearylammonium Chloride Hydrate
||Benzyldimethylstearylammonium Chloride Hydrate is a chemical with mild odor.
||Benzyldodecyldimethylammonium Chloride Dihydrate
||Benzyldodecyldimethylammonium Chloride Dihydrate is a chemical.
||Benzylpenicillin potassium (Penicillin G potassium) is the potassium salt form of penicillin G, a broad-spectrum penicillin antibiotic.
||Bephenium is an activator of B-type Acetylcholine receptor (AChR). Bephenium selectively activates the Hco-L-AChR1 subtype made of Hco-UNC-29.1, Hco-UNC-38, Hco-UNC-63, Hco-ACR-8 subunits. Bephenium hydroxynaphthoate is an anthelmintic agent formerly used in the treatment of hookworm infections and ascariasis.
||Bepotastine is a non-sedating, selective antagonist of the histamine 1 (H1) receptor that is indicated in allergic rhinitis, urticaria, and pruritus associated with skin disease.
||Bepotastine Besilate (TAU 284) is a non-sedating, selective antagonist of histamine 1 (H1) receptor with pIC50 of 5.7.
||Bepridil hydrochloride is an anti-anginal drug classified as a calcium channel blocker. It also blocks multiple other ion channels, including sodium and potassium channels.
||Berbamine (BA), a traditional Chinese medicines extracted from Berberis amurensis (xiaoboan), is a novel inhibitor of bcr/abl fusion gene with potent anti-leukemia activity and also an inhibitor of NF-κB. Berbamine (BA) induces apoptosis in human myeloma cells and inhibits the growth of cancer cells by targeting Ca²⁺/calmodulin-dependent protein kinase II (CaMKII).
||Berbamine (BA, BBM) dihydrochloride, a traditional Chinese medicines extracted from Berberis amurensis (xiaoboan), is a novel inhibitor of bcr/abl fusion gene with potent anti-leukemia activity and also an inhibitor of NF-κB. Berbamine (BA, BBM) dihydrochloride induces apoptosis in human myeloma cells and inhibits the growth of cancer cells by targeting Ca²⁺/calmodulin-dependent protein kinase II (CaMKII).
||Berberine (Umbellatine), an alkaloid isolated from Rhizoma coptidis, has broad applications, particularly as an antibacterial agent in the clinic.
||Berberine chloride (NSC 646666)
||Berberine chloride (NSC 646666, Natural Yellow 18) is a quaternary ammonium salt from the group of isoquinoline alkaloids. Berberine activates caspase 3 and caspase 8, cleavage of poly ADP-ribose polymerase (PARP) and the release of cytochrome c. Berberine chloride decreases the expression of c-IAP1, Bcl-2 and Bcl-XL. Berberine chloride induces apoptosis with sustained phosphorylation of JNK and p38 MAPK, as well as generation of the ROS. Berberine chloride is a dual topoisomerase I and II inhibitor. Berberine chloride is also a potential autophagy modulator.
||Berberine chloride hydrate
||Berberine (Natural Yellow 18) chloride hydrate is a quaternary ammonium salt from the group of isoquinoline alkaloids. Berberine activates caspase 3 and caspase 8, cleavage of poly ADP-ribose polymerase (PARP) and the release of cytochrome c. Berberine chloride decreases the expression of c-IAP1, Bcl-2 and Bcl-XL. Berberine chloride induces apoptosis with sustained phosphorylation of JNK and p38 MAPK, as well as generation of the ROS. Berberine chloride is a dual topoisomerase I and II inhibitor. Berberine chloride is also a potential autophagy modulator.
||Berberine sulfate (Umbellatine), an alkaloid extracted from several plants, possesses antimicrobial activity against a wide variety of microorganisms including Gram-positive and Gram-negative bacteria, fungi, and protozoa.
||Berberrubine (Beroline, 9-Berberoline), an isoquinoline alkaloid isolated from many medicinal plants, possesses diverse pharmacological activities, including glucose-lowering, lipid-lowering, anti-inflammatory, and anti-tumor effects.
Bergamottin is an effective competitive CYP1A1 inhibitor, with a Ki of 10.703 nM.
||Bergapten is a psoralen that can be photoactivated and is capable of crossing-linking DNA, covalently modifying proteins and lipids, and consequently inhibiting cell replication.
||Bergaptol (5-Hydroxypsoralen, 5-Hydroxyfuranocoumarin) is a natural furanocoumarin found in the essential oils of citrus including lemon and bergamot.Bergaptol is a potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 μM.
||Bergenin (Cuscutin) is trihydroxybenzoic acid glycoside and the C-glycoside of 4-O-methyl gallic acid.
||Berzosertib (VE-822, VX970, M6620) is an ATR inhibitor with IC50 of 19 nM in HT29 cells.
||Besifloxacin is a fourth generation fluoroquinolone-type opthalmic antibiotic for the treatment of bacterial conjunctivitis.
||Besifloxacin HCl is a fourth-generation fluoroquinolone antibiotic.
||Besifovir is novel and potent acyclic nucleotide phosphonate used to treat hepatitis B virus (HBV) infection.
||Bestatin (NK421, Ubenimex) is a potent aminopeptidase-B and leukotriene (LT) A4 hydrolase inhibitor, used in the treatment of acute myelocytic leukemia.
||BET bromodomain inhibitor
||BET bromodomain inhibitor is a potent BET inhibitor.
||Beta Carotene is an organic compound and classified as a terpenoid. It is a precursor (inactive form) of vitamin A.
||Beta-Asarone, found in certain plants such as Acorus and Asarum, could pass the blood-brain barrier and exerts neuroprotection effects.
||Beta-Elemonic acid (3-Oxotirucallenoic Acid), a known triterpene isolated from Boswellia (Burseraceae), exhibits anti‑inflammatory effects.
||Beta-Lapachone (β-Lapachone, ARQ-501) is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II or ligase. Phase 2.
Beta-Mangostin, an xanthone compound isolated in Cratoxylum arborescens, which has antibacterial, antimalarial and anticancer activities.
Beta-Mangostin, an xanthone compound isolated in Cratoxylum arborescens, which has antibacterial, antimalarial and anticancer activities.
Beta-Mangostin, an xanthone compound isolated in Cratoxylum arborescens, which has antibacterial, antimalarial and anticancer activities.
Beta-Mangostin, an xanthone compound isolated in Cratoxylum arborescens, which has antibacterial, antimalarial and anticancer activities.
Beta-Mangostin, an xanthone compound isolated in Cratoxylum arborescens, which has antibacterial, antimalarial and anticancer activities.
||Betahistine is an antivertigo drug that primarily acts as a histamine H1 agonist.
||Betahistine (PT-9) is a histamine H3 receptor inhibitor with IC50 of 1.9 μM.
||Betahistine EP Impurity C (NSC19005)
||Betahistine EP Impurity C (NSC19005) is structurally related to Betahistine and is a dimer of Betahistine. It is used as a reagent in the preparation of copper pyridylmethylethylenediamine dicyanamido polymeric complexes.
||Betahistine mesylate is the mesylate salt form of Betahistine, a histamine analog and H3 receptor agonist that serves as a vasodilator.
||Betaine (trimethylglycine, glycine betaine, lycine, oxyneurine), a methyl derivative of glycine first isolated from sugar beets, has been shown to have potential benefits for fighting heart disease, improving body composition, and helping promote muscle gain and fat loss because of its abilities to promote protein synthesis in the body.
||Betamethasone (NSC-39470, SCH-4831) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.
||Betamethasone 21-valerate can be metabolised into betamethasone by skin esterases. Betamethasone Valerate is effective and safe in the treatment of patchy alopecia areata (AA).
||Betamethasone Dipropionate (SCH 11460) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive abilities.
||Betamethasone sodium phosphate
Betamethasone sodium phosphate (Betamethasone 21-Phosphate Disodium Salt) is a potent glucocorticoid with anti-inflammatory activity.
||Betamethasone Valerate is a moderately potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.
||Betamipron (CS-443) is a chemical compound which is used together with panipenem to inhibit panipenem uptake into the renal tubule and prevent nephrotoxicity.
||Betaxolol (SL 75212) is a selective beta1 adrenergic receptor blocker used in the treatment of hypertension and glaucoma.
||Betaxolol (SL 75212) is a β1 adrenergic receptor blocker with IC50 of 6 μM.
||Betazole Dihydrochloride (Ametazole, 2-(3-Pyrazolyl)ethanamine) is a histamine H2 agonist used clinically to test gastric secretory function.
||Bethanechol chloride is a selective muscarinic receptor agonist without any effect on nicotinic receptors.
||Betrixaban is a new, long-acting, oral and selective Factor Xa inhibitor that decreases prothrombinase activity and thrombin generation.
||Betrixaban maleate is the maleate salt form of Betrixaban, which is a Factor Xa inhibitor that decreases prothrombinase activity and thrombin generation.
||Betulin (BE, betulinol, betuline, betulinic alcohol), also known as betulinol, betuline, or betulinic alcohol, is a pentacyclic lupane-type triterpenoid naturally distributed in many plants and displays a broad spectrum of biological and pharmacological properties such as anticancer and chemopreventive activity. Betulin (Trochol), is a sterol regulatory element-binding protein (SREBP) inhibitor with an IC50 of 14.5 μM in K562 cell line.
||Betulinic acid (ALS-357, Lupatic acid, Betulic acid), a pentacyclic triterpenoid from Syzigium claviflorum, is a inhibitor of HIV-1 with EC50 of 1.4 μ M. Betulinic acid acts as a new activator of NF-kB.Phase 1/2.
||Betulinicaldehyde (Betulinal, Betunal), isolated from the bark of tectona grandis., is an anti-tumor agent.
||Betulonic acid (Liquidambaric acid), derived from betulinol, a pentacyclic styrene, has shown a highly specific anti-prostate cancer activity in in vitro cell cultures.
||Bevacizumab (anti-VEGF, Avastin) is a humanized anti-VEGF monoclonal antibody which binds to and neutralizes all human VEGF-A isoforms and bioactive proteolytic fragments, MW:149 KD.
||Bevantolol hydrochloride (NC-1400) is a cardioselective, beta adrenoceptor antagonist, devoid of intrinsic β sympathomimetic activity and with weak membrane-stabilizing and local anesthetic properties.
||Bevirimat (MPC-4326, PA-457, YK-FH312), the prototype Human Immunodeficiency Virus type 1 (HIV-1) maturation inhibitor, is highly potent in cell culture and efficacious in HIV-1 infected patients.
Bevurogant is a retinoid-related orphan receptor-gamma t (RORγt) antagonist. Bevurogant can be used for the research of chronic inflammatory diseases.
Bexagliflozin (EGT1442, EGT-0001442, THR-1442) is a potent and selective SGLT2 inhibitor with an IC50 of 2 nM.
||Bexarotene (Targretin, LGD1069) is a retinoid specifically selective for retinoid X receptors, used as an oral antineoplastic agent in the treatment of cutaneous T-cell lymphoma.
||Bezafibrate (BM 15075) is the first clinically tested dual and pan-PPAR co-agonism.
||BFH772 is a novel potent oral VEGFR2 inhibitor, targeting VEGFR2 kinase with IC50 of 3 nM.
||BFMO (biogenic Fe-Mn oxides)
||BFMO (biogenic Fe-Mn oxides, defined as a mixture of biogenic Mn oxide (BMO) and Fe oxide) could eliminate or decrease Fe(II), Mn(II), and As(III&V) species simultaneously. BFMO can be used for As removal from water containing high concentrations of Fe(II) and Mn(II).
||BGP-15, is a nicotinic amidoxime derivative with PARP inhibitory activity. It has been demonstrated that BGP-15 protects against ischemia-reperfusion injury.
||BGT226 (NVP-BGT226) maleate
||BGT226 (NVP-BGT226) maleate is a novel class I PI3K/mTOR inhibitor for PI3Kα/β/γ with IC50 of 4 nM/63 nM/38 nM. Phase 1/2.
||BHQ (2,5-di-t-butyl-1,4-benzohydroquinone) is a potent and selective inhibitor of the sarco-endoplasmic reticulum Ca2+-ATPase (SERCA).
||BI 01383298 is an irreversible and non-competitive inhibitor of human sodium-coupled citrate transporter (hNaCT), in which the inhibition is evident for the constitutively expressed transporter in HepG2 cells and for the ectopically expressed human NaCT in HEK293 cells, with IC50 of ~100 nM.
||BI-2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. BI-2536 inhibits Bromodomain 4 (BRD4) with Kd of 37 nM and potently suppresses c-Myc expression. BI-2536 induces apoptosis and attenuates autophagy. Phase 2.
||BI 894999 is a potent and selective BET inhibitor with IC50 of 5 nM and 41 nM for the binding of BRD4-BD1 and BRD4-BD2 to acetylated histones, respectively. BI 894999 is highly selective for BRD2/3/4 and BRDT (Kd of 0.49-1.6 nM), with at least a 200-fold selectivity vs. BRD4-BD1.
||BI SF3 is an active compound.
||BI-1347 is small molecule inhibitor of Cyclin-dependent kinase 8(CDK8) with IC50 of 1.1 nM.
||BI-2852 is a potent inhibitor of KRAS that binds with nanomolar affinity to a pocket between switch I and II on RAS. BI-2852 blocks all GEF, GAP, and effector interactions with KRAS, leading to inhibition of downstream signaling and an antiproliferative effect in the low micromolar range in KRAS mutant cells.
||BI-3406 (compound I-13) is a potent, selective and orally active inhibitor of the interaction between KRAS and Son of Sevenless 1 (SOS1) with IC50 of 5 nM. BI-3406 reduces the formation of GTP-loaded KRAS, and inhibits MAPK pathway signaling. BI-3406 exhibits anti-tumor activities.
||BI-3802 is a highly potent oncogenic transcription factor BCL6 degrader with strong de-repression of target genes anti-proliferative effects. BI-3802 inhibits the BTB domain of BCL6 with IC50 of ≤3 nM. BI-3802 exhibits antitumor activity.
||BI-3812 is a highly potent and efficacious BCL6 inhibitor probe compound with an IC50 less than 3 nM.
||BI-4020 is an orally active, non-covalent EGFR inhibitor with IC50 of 0.6 nM and 0.2 nM for EGFRdel19 T790M C797S as biomarker potency and anti-proliferation potency in BaF3 cells, respectively.
||BI 409306 (SUB 166499) is a potent and selective inhibitor of human and rat PDE9A with mean IC50 of 65 nM and 168 nM, respectively. Treatment with BI 409306 increases brain cGMP levels, promotes long-term potentiation, and improves episodic and working memory performance in rodents.
||BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM.
||BI-671800 (AP-761, Cmpd A) is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2) with IC50 of 4.5 nM and 3.7 nM for PGD2 binding to human CRTH2 and murine CRTH2, respectively. BI-671800 is associated with a small improvement in FEV1 in symptomatic controller-naïve asthma patients, and in patients on ICS.
||BI-6C9 is a highly specific BH3 interacting domain (Bid) inhibitor, which prevents mitochondrial outer membrane potential (MOMP) and mitochondrial fission, and protects the cells from mitochondrial apoptosis inducing factor (AIF) release and caspase-independent cell death in neurons.
||BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Phase 1.
||BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B. BI-D1870 exhibits anticancer attributes including the generation of reactive oxygen species (ROS) and increases in endoplasmic reticulum (ER) stress and autophagy.
BI6015, a hepatocyte nuclear factor 4α (HNF4α) antagonist, induces loss of HNF4α expression and hepatic steatosis in vivo. BI6015 is cytotoxic to human hepatocellular carcinoma (HCC).
||BIA (TMBIM6 antagonist BIA), a potential TMBIM6 antagonist, is an inhibitor of the interaction between TMBIM6 (Transmembrane B cell lymphoma 2-associated X protein (BAX) inhibitor motif-containing 6) and mTORC2, which ultimately blocks AKT activation and cancer progression.
||BIA 10-2474 is a novel fatty acid amide hydrolase (FAAH) inhibitor, with a potent inhibitory effect upon FAAH and prolonged action in vivo.
||Biapenem (L-627, LJC10627) is a carbapenem antibiotic with activity against both Gram-positive and Gram-negative bacterial strains.
Biatractylolide, a native compound isolated from Atractylodis Macrocephalae Rhizoma root, has inhibitory activities on acetylcholinesterase (AChE).
||BIBF-0775 is a selective inhibitor of transforming growth factor β Receptor I (TGFβRI,Alk5) with an IC50 of 34nM.
||BIBO 3304 Trifluoroacetate
BIBO 3304 Trifluoroacetate (BIBO-3304 TFA) is a novel neuropeptide Y Y1 receptor (NPY1R) antagonist with IC50 values of 0.38 nM and 0.72 nM for human Y1 receptor and rat Y1 receptor, respectively. BIBO 3304 shows low affinity for the human Y2 receptor, human and rat Y4 receptor as well as for the human and rat Y5 receptor (IC50 values >1000 nM).
||BIBR 1532 is a potent, selective, non-competitive telomerase inhibitor with IC50 of 100 nM in a cell-free assay. No inhibition of DNA and RNA polymerases, including HIV reverse transcriptase are observed at concentrations vastly exceeding the IC50 for telomerase. BIBR 1532 induces apoptosis in cancer cells.
||Bicalutamide (ICI-176334) is an androgen receptor (AR) antagonist with IC50 of 0.16 μM in LNCaP/AR(cs)cell line. Bicalutamide promotes autophagy.
||Bicinchoninic acid disodium salt
||Bicinchoninic acid disodium salt is used for determination of reducing sugar and protein though Copper.
||Bicine (N,N-Bis(2-hydroxyethyl)glycine, Diethylolglycine, Diethanol glycine, Dihydroxyethylglycine) is an organic compound used as a buffering agent.
||Bictegravir (GS-9883) is a novel, potent, once-daily, unboosted inhibitor of HIV-1 integrase.
Bictegravir (GS-9883) Sodium is a novel and potent inhibitor of HIV-1 integrase, specifically targets IN strand transfer activity with an IC50 of 7.5 nM.
||Bicyclol (SY-801) is a drug that can improve liver function and inhibit HBV replication.
||Bidens Bipinnata Extract
||Bifemelane hydrochloride (MCI-2016)
||Bifemelane hydrochloride (MCI-2016) is a potent, selective and competitive monoamine oxidase A (MAO-A) inhibitor with Ki of 4.20 μM and a noncompetitive inhibitor of MAO-B with Ki of 46.0 μM. Bifemelane hydrochloride exhibits potent antidepressant activity and can be used for the research of cognitive and emotional disturbances related to cerebrovascular disease.
||Bifendate, a synthetic intermediate of schisandrin C, is an anti-HBV drug used in Chinese medicine for the treatment of chronic hepatitis B.
||Bifonazole (Bay h 4502) is a substituted imidazole antifungal agent.
||Bigelovin, a sesquiterpene lactone isolated from Inula helianthus-aquatica, is a selective retinoid X receptor α agonist.
||BIIB068 is a potent, selective, reversible and orally active inhibitor of BTK with IC50 of 1 nM and Kd of 0.3 nM, respectively.
||BIIB021 (CNF2024) is an orally available, fully synthetic small-molecule inhibitor of HSP90 with Ki and EC50 of 1.7 nM and 38 nM, respectively. Phase 2.
||Bilastine is a new, well-tolerated, nonsedating H1 receptor antihistamine and has a rapid onset and prolonged duration of action.
||Bilibubin (Bilirubin) is a tetrapyrrole and a breakdown product of heme catabolism that acts as a physiological, chain-breaking antioxidant.
||Bilobalide is a biologically active terpenic trilactone present in Ginkgo biloba.
||Bilobetin is an active ingredient isolated from Ginkgo biloba, which can reduce blood lipids and improve the effect of insulin.
||Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension.
||Bimiralisib (PQR309) is a novel brain-penetrant dual PI3K/mTOR inhibitor with in vitro and in vivo antilymphoma activity. It displays excellent selectivity versus PI3K-related lipid kinases, protein kinases and unrelated targets.
||Bindarit (AF 2838)
||Bindarit (AF 2838) exhibits selective inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.
||Binimetinib (MEK162, ARRY-162, ARRY-438162) is a potent inhibitor of MEK1/2 with IC50 of 12 nM in a cell-free assay. Binimetinib induces G1 cell cycle arrest and apoptosis in human NSCLC cell lines and induces autophagy. Phase 3.
||BIO (GSK-3 Inhibitor IX, 6-bromoindirubin-3-oxime, 6-Bromoindirubin-3'-oxime, MLS 2052) is a specific inhibitor of GSK-3 with IC50 of 5 nM for GSK-3α/β in a cell-free assay, shows >16-fold selectivity over CDK5, also a pan-JAK inhibitor with IC50 of 30 nM for Tyk2. BIO induces apoptosis in human melanoma cells.
||BIO-acetoxime (GSK-3 Inhibitor X) is a potent dual GSK3α/β inhibitor with IC50 of 10 nM, >240-fold selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B.
||Bioactive Compound Library-I
||A unique collection of 8268 bioactive compounds for high throughput screening (HTS) and high content screening (HCS).
||Bioactive Compound Library-Ⅱ
||A unique collection of 5309 bioactive compounds for high throughput screening (HTS) and high content screening (HCS).
||Biochanin A (4-Methylgenistein), an O-methylated isoflavone from Trifolium pratense, inhibits protein tyrosine kinase (PTK) of epidermal growth factor receptor with IC50 values of 91.5 μM.
||Biocytin ((+)-Biocytin, Biotinyl-L-lysine) is a conjugate of D-biotin and L-lysine. Biocytin is an attractive neuronal tracer. It labels neurons fast over long distances, and it can be used in conjunction with calcium dyes to report on neuronal activity in retrogradely labeled live neurons.
||BioE-1115 is a highly selective and potent dual inhibitor of PAS kinase (PASK) and casein kinase 2α (CK2α) with IC50 of ~4 nM and ~10 μM, respectively.
||Biotin (Vitamin B7)
||Biotin is a water-soluble B-vitamin and is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids.
||Biotin-PEG4-acid is a PEG-based PROTAC linker that is applicable to the synthesis of PROTAC.
||Biotin-PEG6-alcohol is a biotin-labeled and PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Biotin-PFP ester is an alkyl/ether-based PROTAC linker that is applicable to the synthesis of PROTACs.
Biotinyl Tyramide is a biotin derivative used for signal amplification in IHC and fluorescent in situ hybridization (ISH).
||BiP Inducer X (BIX)
BiP Inducer X (BIX) is a selective GRP78 (BiP, HSPA5) inducer. BIX induces BiP only, in a dose-dependent manner, without induction of other molecules involved in the ER stress response.
||Biphenyl-4-sulfonyl chloride (p-Phenylbenzenesulfonyl, 4-Phenylbenzenesulfonyl, p-Biphenylsulfonyl) is a HDAC inhibitor with synthetic applications in palladium-catalyzed desulfitative C-arylation.
||Birabresib (OTX015, MK 8628) is a potent BET bromodomain inhibitor with EC50 ranging from 10 to 19 nM for BRD2, BRD3, and BRD4 in cell-free assays. Birabresib inhibits the expression of Nuclear receptor binding SET domain protein 3 (NSD3) target genes.
||Birinapant (TL32711) is a SMAC mimetic antagonist, mostly to cIAP1 with Kd of <1 nM in a cell-free assay, less potent to XIAP. Birinapant helps to induce apoptosis in latent HIV-1-infected cells. Phase 2.
Bis(2-ethylhexyl) phthalate (Dioctyl phthalate, DOP, Diplast O, ESBO-D 82, Ergoplast FDO, Ergoplast FDO-S, Etalon) induces DNA strand breaks and gene expression alterations in larval zebrafish Danio rerio.
||Bis(2-Methyl-3-furyl) disulfide is a volatile sulfur compound that is a key contributor to the meat-like aroma in cooked meat.
||Bis-NH2-C1-PEG3 (PROTAC Linker 24) is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Bis-NH2-PEG2 is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Bis-PEG1-NHS ester is a non-cleavable 1-unit PEG linker for antibody-drug-conjugation (ADC).
||Bis-PEG3-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
||Bis-PEG3-NHS ester is a non-cleavable 3-unit PEG linker that can be used for antibody-drug-conjugation (ADC).
||Bis-PEG5-NHS ester is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
||Bis-PEG8-acid is a PEG-based PROTAC linker can be applied into the synthesis of PROTACs. Bis-PEG8-acid is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
||Bis-Tos-PEG4 is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Bis-Tos-PEG6 is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Bis-PEG2-NHS ester is a non-cleavable 2-unit PEG linker used for antibody-drug-conjugation (ADC).
||Bis-PEG4-NHS ester is a noncleavable 4-unit PEG linker for antibody-drug-conjugation (ADC).
||Bisacodyl (INN) is a stimulant laxative drug that works directly on the colon to produce a bowel movement.
Bisantrene (CS1, NSC-337766, CL 216,942) is an anthracene derivative with anti-tumor activity. Bisantrene also is a potent and selective FTO inhibitor.
||Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin and possesses several biological activities, such as anti-inflammation and anti-cancer activities.
||Bisindolylmaleimide I (GF109203X)
||Bisindolylmaleimide I (GF109203X, GO 6850) is a potent PKC inhibitor with IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ in cell-free assays, respectively, showing more than 3000-fold selectivity for PKC as compared to EGFR, PDGFR and insulin receptor.
||Bisindolylmaleimide IV (Arcyriarubin A, BIM IV, Compound 5/1a) is a potent inhibitor of protein kinase C (PKC) with IC50 of 0.55 μM. Bisindolylmaleimide IV also inhibits PKA with IC50 of 11.8μM. Bisindolylmaleimide IV is a potent, selective inhibitor of human cytomegalovirus (HCMV) replication in cell culture with IC50 of 0.2 μM.
||Bisindolylmaleimide VIII (acetate)
||Bisindolylmaleimide VIII (acetate) (Ro 31-7549 acetate) is a potent and selective protein kinase C (PKC) inhibitor with an IC50 of 158 nM for rat brain PKC, also exerting IC50s of 53, 195, 163, 213, and 175 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, PKC-ε, respectively.
||Bismuth Subcitrate Potassium
||Bismuth Subcitrate is an antibiotic used to treat stomach ulcers associated with Helicobacter pylori, a bacterial infection.
||Bismuth Subsalicylate is the active ingredient in Pepto-Bismol and inhibits prostaglandin G/H Synthase 1/2.
||Bisoctrizole (Tinosorb M, Tinuvin-360, UV-360, Milestab-360) is a broad-spectrum ultraviolet radiation absorber, absorbing UVB as well as UVA rays. Also a hybrid UV absorber, reflecting and scattering UV.
||Bisoprolol is a cardioselective β1-adrenergic blocking agent used for secondary prevention of myocardial infarction (MI), heart failure, angina pectoris and mild to moderate hypertension.
||Bisoprolol fumarate (EMD33512) is a selective type β1 adrenergic receptor blocker.
||Bisphenol A is a starting material for the synthesis of plastics, primarily certain polycarbonates and epoxy resins, as well as some polysulfones and certain niche materials. It exhibits estrogen-mimicking, hormone-like properties.
||Bithionol (Actamer) is a potent inhibitor of soluble adenylyl cyclase(sAC) with an IC50 of 4 μM and has antibacterial and anthelmintic properties along with algaecide activity.
||Bitopertin (RG1678,RO-4917838) is a potent inhibitor of glycine transporter 1 (GlyT1), with Ki of 8.1 nM for human hGlyT1b and IC50 of 22-25 nM in Chinese hamster ovary cells.
||Bitter almond Extract
||Bivalirudin Trifluoroacetate is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin.
||BIX01294 is an inhibitor of G9a histone methyltransferase with IC50 of 2.7 μM in a cell-free assay, reduces H3K9me2 of bulk histones, also weakly inhibits GLP (primarily H3K9me3), no significant activity observed at other histone methyltransferases. BIX01294 induces autophagy. BIX01294 also inhibits H3K36 methylation by oncoproteins NSD1, NSD2 and NSD3.
||BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM, also inhibits ERK5 catalytic activity with IC50 of 59 nM in cell-free assays, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2.
Bixin, isolated from the seeds of <i>Bixa orellana</i>, is a carotenoid, possessing anti-inflammatory, anti-tumor and anti-oxidant activities. Bixin treatment ameliorated cardiac dysfunction through inhibiting fibrosis, inflammation and reactive oxygen species (ROS) generation.
||BL-918 is a potent, orally active activator of UNC-51-like kinase 1 (ULK1) with EC50 of 24.14 nM and Kd of 0.719 μM. BL-918 induces cytoprotective autophagy for Parkinson's disease treatment.
||Black Ant Extract
||Black Bone Rattan extract
||Black Carrot Extract
||Black Coffee Extract
||Black Cohosh Extract
||Black Garlic Extract
||Black Pepper Extract
||Black PN (Brilliant Black BN) is a black dye that provides a blackish violet shade in applications.
||Black Quinoa Extract
||Black Sesame Extract
||Black Soya Bean Extract
||Black Tea Extract
||Black Tea Root Extract
||Blasticidin S HCl
||Blasticidin S HCl is a nucleoside antibiotic isolated from Stretomyces girseochromogenes, and acts as a DNA and protein synthesis inhibitor, used to select transfected cells carrying bsr or BSD resistance genes.
||Bleomycin (NSC125066) sulfate
||Bleomycin Sulfate (NSC125066) is a glycopeptide antibiotic and an anticancer agent for squamous cell carcinomas (SCC) with IC50 of 4 nM in UT-SCC-19A cells.
||Bletilla Striata Root Extract
||Blighted Wheat Extract
||Blinin, isolated from the whole plant of Conyza blinii, is used in folk medicine in the south-west of China.
||Blonanserin (AD 5423) is a relatively selective serotonin (5-HT)2A and dopamine D2 antagonist, used the treatment of schizophrenia.
||BLT-1 is an inhibitor of HDL receptor SR-BI. BLT-1 is primarily used for phosphorylation and dephosphorylation applications.
BLU-945 effectively inhibits EGFR with L858R and/or exon 19 deletion mutation, T790M mutation, and C797S mutation. BLU-945 facilitates efficacious dosing and reduces EGFR-mediated on-target toxicities. S BLU-945 has the potential for the research of cancer disease (extracted from patent WO2021133809A1, compound 112).
||BLU9931 is a potent, selective, and irreversible FGFR4 inhibitor with IC50 of 3 nM, about 297-, 184-, and 50-fold selectivity over FGFR1/2/3, respectively.
||Blueberry Fruit Extract
||Blue indigo Extract
||Blumeatin, a compound isolated from Blumea balsamifera DC, can protect liver against injury induced by CCl4 and thioacetamide.
||BLZ945 is an orally active, potent and selective CSF-1R inhibitor with IC50 of 1 nM, >1000-fold selective against its closest receptor tyrosine kinase homologs.
||BM212 is a potent inhibitor of the intracellular mycobacteria, exerting bactericidal activity against intracellular bacilli residing.
||BM213, a selective C5aR1 agonist with an EC50 of 59 nM, induces C5aR1-mediated calcium mobilization and pERK1/2 signaling but not β-arrestin recruitment. BM213 is much more stable in serum and displays no cytotoxicity on SHSY-5Y cells.
||BMF-219 is a novel, potent, irreversible menin inhibitor, can be used in the treatment of leukemia.
||BML-190 (IMMA) is a selective cannabinoid CB2 receptor inverse agonist with Ki of 435 nM, with 50-fold selectivity over CB1 receptor.
||BML-210 (CAY10433) is a small molecule inhibitor of HDAC.BML-210 inhibits the HDAC4-VP16-driven reporter signal in a dose-dependent manner with an apparent IC50 of ∼5 µM.
||BMOV (Bis maltolato oxovanadium, Bis(maltolato)oxovanadium (IV)) is a potent oral vanadium complex with anti-diabetic properties and
insulin-mimicking effects.BMOV is shown to improve cardiac dysfunctions in diabetic models.
||BMPS is a noncleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
||BMS-1 (PD-1/PD-L1 inhibitor 1)
||BMS-1 (PD-1/PD-L1 inhibitor 1, PD1-PDL1-IN1) is a small-molecule inhibitor of PD-1/PD-L1 interaction with IC50 of 6 nM.
||BMS-1001 is a potent inhibitor of PD-1/PD-L1 interaction with EC50 of 253 nM. BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes.
||BMS-1166 is a novel and potent small molecule inhibitor of the PD-1/PD-L1 interaction with an IC50 of 1.4 nM.
||BMS-191011 (BMS-A), an opener of large-conductance Ca2+-activated potassium channels, dilates rat retinal arterioles in vivo.
||BMS-265246 is a potent and selective CDK1/2 inhibitor with IC50 of 6 nM/9 nM in a cell-free assay. It is 25-fold more selective for CDK1/2 than CDK4.
||BMS-3 is a potent inhibitor of LIM kinases (LIMKs) with IC50 of 5 nM and 6 nM for LIMK1 and LIMK2, respectively.
||BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM in cell-free assays, respectively.
||BMS-378806 (BMS 806) selectively inhibits the binding of HIV-1 gp120 to the CD4 receptor with EC50 of 0.85-26.5 nM in virus.
||BMS-5 (LIMKi 3) is a potent inhibitor of LIM kinases (LIMK) with IC50 of 7 nM and 8 nM for LIMK1 and LIMK2, respectively.
||BMS-536924 (CS-0117) is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for Akt1, MAPK1/2.
||BMS-582949 (PS540446) is a potent and selective p38 mitogen-activated protein kinase (p38 MAPK) inhibitor with IC50 of 13nM,inhibiting both p38 kinase activity and activation of p38.
||BMS-687453 (compound 2) is a potent and selective agonist of PPARα with EC50 of 10 nM and IC50 of 260 nM for human PPARα.
||BMS-707035 is a specific HIV-I integrase (IN) inhibitor with IC50 of 15 nM. Phase 2.
||BMS-754807 is a potent and reversible inhibitor of IGF-1R/InsR with IC50 of 1.8 nM/1.7 nM in cell-free assays, less potent to Met (c-Met), Aurora A/B, TrkA/B and Ron, and shows little activity to Flt3, Lck, MK2, PKA, PKC etc. Phase 2.
||BMS-777607 (BMS 817378) is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3 with IC50 of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM in cell-free assays, 40-fold more selective for Met-related targets versus Lck, VEGFR-2, and TrkA/B, and more than 500-fold greater selectivity versus all other receptor and non receptor kinases. Phase 1/2.
||BMS-794833 is a potent ATP competitive inhibitor of Met (c-Met)/VEGFR2 with IC50 of 1.7 nM/15 nM, also inhibits Ron, Axl and Flt3 with IC50 of <3 nM; a prodrug of BMS-817378. Phase 1.
||BMS-813160 is a potent, well-absorbed dual CCR2 and CCR5 chemokine antagonist. BMS-813160 inhibits inflammatory processes, angiogenesis, tumor cell migration, tumor cell proliferation and invasion.
||BMS-833923 (XL139) is an orally bioavailable Smoothened antagonist. Phase 2.
||BMS-911543 is a potent and selective inhibitor of JAK2 with IC50 of 1.1 nM, ~350-, 75- and 65-fold selective to JAK1, JAK3 and TYK2, respectively. Phase 1/2.
||BMS-935177 is a potent, reversible Bruton's Tyrosine Kinase (BTK) inhibitor with an IC50 value of 2.8 nM and demonstrates good kinase selectivity. It is more potent against BTK than other kinase, including the other Tec family kinases (TEC, BMX, ITK, and TXK) over which the compound is between 5- and 67-fold selective.
||BMS-986020 (AM152, AP-3152 free acid) is a potent and selective antagonist of lysophosphatidic acid receptor 1 (LPA1). BMS-986020 inhibits bile acid and phospholipid transporters with IC50 of 4.8 μM, 6.2 μM, and 7.5 μM for BSEP, MRP4, and MDR3, respectively. BMS-986020 has the potential for the treatment of idiopathic pulmonary fibrosis (IPF).
||BMS-986122 is a selective, potent positive allosteric modulator of the mu-opioid receptor (µ-OR), shows potentiation of orthosteric agonist-mediated β-arrestin recruitment, adenylyl cyclase inhibition, and G protein activation, and potentiates DAMGO-mediated [35S]GTPγS binding in mouse brain membranes.
||BMS-986158 is a potent inhibitor of BET with IC50s of 6.6 nM and 5 nM in NCI-H211 small cell lung cancer (SCLC) cells and MDA-MB231 triple negative breast cancer (TNBC) cells, respectively.
||BMS-986176 (LX-9211,AAK1-IN-1) is a highly selective, brain-penetrant, potent AAK1 (adaptor associated kinase 1) inhibitor with an IC50 of 2 nM.
||BMS-986187 is a potent and selective positive allosteric modulator (PAM) of the δ-opioid receptor and a G-protein-biased allosteric agonist.
||BMS-986188 is a positive allosteric modulator (PAM) of δ-opioid receptors with EC50 of 0.05 μM in a β-arrestin recruitment assay.
||BMS-986260 is a potent, selective, and orally bioavailable inhibitor of TGFβR1 with IC50 of 1.6 nM.
BMS-986299 is a novel NLRP3 agonist that induces IL8 release to activate natural killer (NK) cells.
||BMS-P5, a potent selective pharmacological inhibitor of PAD4, is used to evaluate the effect of PAD4 inhibition on multiple myeloma (MM)-induced neutrophil extracellular trap (NET) formation.
||BMS-303141 is a potent, cell-permeable inhibitor of ATP-citrate lyase (ACL) with IC50 of 0.13 μM. BMS-303141 shows inhibition of total lipid syntheses with IC50 of 8 μM in HepG2 cells.
||BMS309403 is a small-molecule FABP4 inhibitor with nM affinity (Kd=4 nM for FABP4) and >100-fold selectivity against FABP5 as well as the heart isoform FABP3.
||BMVC-8C3O is a DNA G-quadruplexe (G4) ligand that induces topological conversion of non-parallel to parallel forms in human telomeric DNA G4s.
||BMY 7378 Dihydrochloride
||BMY 7378 is a multi-targeted inhibitor of α2C-adrenoceptor and α1D-adrenoceptor with pKi of 6.54 and 8.2, respectively, and acts as a mixed agonist and antagonist for 5-HT1A receptor with pKi of 8.3.
||BNC105, a novel compound developed as a Vascular Disrupting Agent (VDA) for treatment of cancer, is a tubulin polymerization inhibitor.
||BNC210 (H-Ile-Trp-OH, IW-2143) is a negative allosteric modulator of alpha-7 nicotinic acetylcholine receptor (α7 nAChR).
||BnO-PEG4-OH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||BnO-PEG5-OH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||BnO-PEG6-OH is a non-cleavable 6-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
||BO-264 is a potent and orally active inhibitor of transforming acidic coiled-coil 3 (TACC3) with IC50 of 188 nM and Kd of 1.5 nM. BO-264 specifically blocks the function of FGFR3-TACC3 fusion protein. BO-264 induces SAC-dependent mitotic arrest, apoptosis and DNA damage with antitumor activities.
||Boat-fruited sterculia seed Extract
||Bobcat339 is a selective cytosine-based TET enzyme inhibitor with IC50 of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 can reduce DNA 5-hydroxymethylcytosine abundance by inhibiting TET enzyme function in living cells and provide support for its utility as a viable pharmacological probe.
||Boc-11-aminoundecanoic acid is an Alkyl/ether-based PROTAC linker that is applicable to the synthesis of MS432.
||BOC-Dap-NE is an active compound.
||Boc-GABA-OH is a PROTAC linker that can be applied to synthesis UNC6852, an EED-targeted PROTAC.
||Boc-Gly-Gly-Phe-Gly-OH (GGFG) is a self-assembly of N- and C-protected tetrapeptide, a protease cleavable linker used for the antibody-drug conjugates (ADCs).
||Boc-N-Amido-PEG2-C2-azide is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Boc-N-Amido-PEG3-azide is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Boc-NH-C6-Br is a cleavable linker applied into the synthesis of antibody-drug conjugates (ADCs).
||Boc-NH-PEG1-CH2COOH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Boc-NH-PEG12-CH2CH2COOH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Boc-NH-PEG2-C2-NH2 is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Boc-NH-PEG2-CH2COOH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Boc-NH-PEG3 is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Boc-NH-PEG4 is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Boc-NH-PEG4-CH2CH2COOH is a PEG-based PROTAC linker can be applied into the synthesis of PROTAC. Boc-NH-PEG4-CH2CH2COOH is a cleavable ADC linker used as a linker for antibody-drug conjugates (ADC).
||Boc-NH-PEG4-CH2CH2NH2 a cleavable 5-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
||Boc-NH-PEG6-azide is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Boc-NH-PEG7-acid is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Boc-NH-PEG7-azide is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Boc-NH-PEG8-CH2CH2COOH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Boc-Val-Cit-OH is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
||Boc-Val-Cit-PAB-PNP is a cleavable linker of ADC that is used in the synthesis of antibody-drug conjugates (ADCs).
||Boceprevir (EBP 520, SCH 503034) is an oral, direct acting hepatitis C virus (HCV) protease inhibitor with Ki value of 14 nM for NS3. It is used in combination with other antiviral agents in the treatment of chronic hepatitis C, genotype 1.
||Boesenbergia Pandurata Extract
||Bohemine is a CDK inhibitor with IC50s of 4.6, 83, and 2.7 μM for Cdk2/cyclin E, Cdk2/cyclin A, and Cdk9/cyclin T1, respectively.
||Boldenone (Dehydrotestosterone) is an anabolic steroid developed for veterinary use, mostly for treatment of horses.
||Boldenone is an agonist of the androgen receptor (AR). Boldenone Undecylenate is a derivative of testosterone, which has strong anabolic effect and only moderately androgenic.
||Boldine, isolated from Peumus boldus, has alpha-adrenergic antagonist activities in vascular tissue with anti-oxidant, hepatoprotective, cytoprotective, antipyretic and anti-inflammatory effects.
Bombesin, a tetradecapeptide, plays an important role in the release of gastrin and the activation of G-protein receptors.
||Bombyx Moril Extract
||Bones of Cervus elaphus’ Extract
||Borneol is a bicyclic monoterpenoid compound extracted from medicinal plants such as Blumea balsamifera, and Dryobalanops aromatica. It is a TRPM8 agonist that increases ocular surface wetness.
||Bornyl acetate (Isobornyl, Bornyl acetic ether, 2-Camphanol), the main volatile constituent in numerous conifer oils and some Chinese traditional herbs, exhibits anti-inflammatory property and it is used as an analgesic.
||Borofalan (10B) (SPM-011; Steboronine), a Ionising radiation emitter, can be used to treat the head and neck cancer.
||Bortezomib (PS-341, Velcade, LDP-341, MLM341, NSC 681239) is a potent 20S proteasome inhibitor with Ki of 0.6 nM. It exhibits favorable selectivity towards tumor cells over normal cells. Bortezomib (PS-341) inhibits NF-κB and induces ERK phosphorylation to suppress cathepsin B and inhibit the catalytic process of autophagy in ovarian cancer and other solid tumors.
||Borussertib is a covalent-allosteric inhibitor of protein kinase Akt with an IC50 of 0.8 nM and a Ki of 2.2 nM for WT Akt.
||BOS-318 is a potent, slowly dissociating, highly selective, and cell-permeable furin inhibitor with IC50 value of 1.9 nM.
||BOS172722 is a monopolar spindle 1 (MPS1) checkpoint inhibitor with IC50 of 11 nM, Ki of 0.11 nM.
||Bosentan (Ro 47-0203) is an endothelin (ET) receptor antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively.
||Bosutinib (SKI-606) is a novel, dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM in cell-free assays, respectively. Bosutinib also effectively decreases the activity of PI3K/AKT/mTOR, MAPK/ERK and JAK/STAT3 signaling pathways by blocking the phosphorylation levels of p-ERK, p-S6, and p-STAT3. Bosutinib promotes autophagy.
||Box5, a Wnt5a-derived N-butyloxycarbonyl hexapeptide (t-Boc-Met-Asp-Gly-Cys-Glu-Leu), acts as an Wnt5a antagonist, inhibits the basal migration and invasion of Wnt5a-expressing HTB63 melanoma cells, antagonizes the effects of Wnt5a on melanoma cell migration and invasion by directly inhibiting Wnt5a-induced PKC and Ca(2+) signaling.
||Bozitinib (PLB-1001, CBT-101, APL-101, CBI-3103) is a highly selective ATP-competitive c-Met inhibitor with blood-brain barrier permeability. Bozitinib (PLB-1001) selectively inhibits MET-altered tumor cells in preclinical models.
||BP 897 is a potent and selective agonist of dopamine D3 receptor and a weak antagonist of dopamine D2 receptor with Ki of 0.92 nM and 61 nM for D3 and D2 receptors, respectively. BP 897 shows low affinities at D1 and D4 receptors with Ki of 3 µM and 0.3 µM, respectively.
||BPC157 (Bepecin, PL 14736), a small, chemically synthesised pentadecapeptide and a partial sequence of the human gastric juice protein BPC, which has been shown to be safe in clinical trials for inflammatory bowel disease and may be able to cure intestinal anastomosis dehiscence.
||BPR1J-097 is a novel potent inhibitor of FLT3 with IC50 of 11 nM.
||BPR1K871 (DBPR114) is a potent and selective dual inhibitor of FLT3 and AURKA with IC50 of 19 nM and 22 nM, respectively. BPR1K871 (DBPR114) acts as a preclinical development candidate for anti-cancer therapy.
||BPTES is a potent and selective Glutaminase GLS1 (KGA) inhibitor with IC50 of 0.16 μM. It has no effect on glutamate dehydrogenase activity and causes only a very slight inhibition of γ-glutamyl transpeptidase activity.
||BPTU (BMS-646786) is a novel allosteric antagonist of P2Y1.
||bpV (HOpic) (Bisperoxovanadium (HOpic)) is a potent inhibitor of PTEN with an IC50 of 14 nM. The IC50s for PTP-β and PTP-1B are about 350- and 1800-fold higher than the IC50 for PTEN, respectively.
||BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2.
||BQCA (benzylquinolone carboxylic acid) is a highly selective positive allosteric modulator of the M1 muscarinic acetylcholine receptor (mAChR).
||BQR695 (NVP-BQR695) is a quinoxaline that displays sub-micromolar potency against human PI4KIIIβ (IC50~90 nM).
||BQT is a bound ligand of 6epv which is the ATAD2 bromodomain in complex with compound 5.
||BQU57, a derivative of RBC8, is a selective GTPase Ral inhibitor relative to the GTPases Ras and RhoA.
||Br-C10-methyl ester is a PROTAC linker that refers to the alkyl/ether composition. Br-C10-methyl ester is applicable to the synthesis of a series of PROTACs.
||Br-PEG3-C2-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Br-PEG3-OH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Br-PEG4-CH2-Boc is a PEG- and Alkyl/ether-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Br-PEG4-OH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Bractoppin, a drug-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem (t)BRCT domain, which selectively inhibits substrate binding with nanomolar activity (IC50 = 0.074 μM) in vitro.
Bradykinin is a potent vasodilator peptide that exerts its vasodilatory action through stimulation of specific endothelial B2 receptors, thereby causing the release of prostacyclin, NO, and EDHF.
||Branaplam (LMI070) is a highly selective, small-molecule splicing modulators of survival motor neuron‑2 (SMN2) with an EC50 of 0.02 μM.
Brandioside is a natural phenylpropanoid glycoside from <i>Brandisia hancei</i>.
||Branebrutinib (BMS-986195) is a potent inhibitor of BTK with IC50 values of 0.1 nM, 0.9 nM, 1.5 nM, 5 nM for BTK, TEC, BMX, TXK, respectively.
||Brassica juncea seed Extract
Brassica juncea seed Extract, isolated from the seeds of brown (<i>Brassica juncea</i>) mustard, contains abundant phenolic compound.
||Brassica rapa Extract
Brassicasterol is a major sterol in rapeseed and canola oil and also found in marine algae and shellfish, which shows to inhibit sterol δ 24-reductase, an enzyme involved in cholesterol biosynthesis in mammals.
||Brassinazole (BRZ) is a potent inhibitor of brassinosteroid (BR) biosynthesis with IC50 of ~ 1 μM, that has been developed to probe the myriad functions of brassinosteroids. Brassinosteroids are a class of phytohormones with essential roles in plant growth and development, including the promotion of stem elongation and cell division.
||Brazilin (Natural Red 24) is a red pigment obtained from the wood of the brazilwood family. It is used to dye fabric and has diverse biological activities, including neuroprotective, anti-inflammatory, antibacterial, and antioxidant properties.
||BRD0539 is a potent inhibitor of Streptococcus pyogenes Cas9 (SpCas9) with IC50 of 22 μM in an in vitro DNA cleavage assay.
BRD0639 is a first-in-class PBM-competitive small molecule inhibitor that disrupts the PRMT5-RIOK1 complex with IC50s of 7.5 μM and 16 μM in permeabilized and living cells, respectively.
||BRD0705 is a potent, paralog selective and orally active inhibitor of GSK3α (Glycogen synthase kinase 3α) with IC50 of 66 nM and Kd of 4.8 μM. BRD0705 also inhibits GSK3β with IC50 of 515 nM. BRD0705 can be used for acute myeloid leukemia (AML).
||BRD3308 is a potant and highly selective inhibitor of HDAC3 with IC50 of 54 nM, 1.26 μM and 1.34 μM for HDAC3, HDAC1 and HDAC2, respectively. BRD3308 activates HIV-1 transcription. BRD3308 suppresses pancreatic β-cell apoptosis induced by inflammatory cytokines (glucolipotoxic stress) and increases functional insulin release.
||BRD6989 is a selective inhibitor of CDK8 and CDK19. BRD6989 upregulates IL-10. BRD6989 is an analog of the natural product cortistatin A (dCA).
||BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression.
||BRD9539 is an inhibitor of histone methyltransferase G9a with IC50 of 6.3 μM. BRD9539 also inhibits PRC2 activity.
||Brefeldin A is a lactone antibiotic and ATPase inhibitor for protein transport with IC50 of 0.2 μM in HCT 116 cells, induces cancer cell differentiation and apoptosis. It could also improve the HDR(homology-directed repair) efficiency and be an enhancer of CRISPR-mediated HDR. Brefeldin A is also an inhibitor of autophagy and mitophagy.
||Bremelanotide Acetate (PT-141 Acetate) is a melanocortin receptor (MCR) agonist recently approved in the USA for the treatment of premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD), as characterized by low sexual desire that causes marked distress or interpersonal difficulty.
||Brepocitinib (PF-06700841, PF-841) is a potent inhibitor of Tyk2 and Jak1 with IC50s of 23 nM, 17 nM, 77 nM for Tyk2, Jak1 and Jak2 respectively. It has appropriate in-family selectivity against JAK2 and JAK3.
||Brequinar (DUP785, NSC 368390) is an inhibitor of dihydroorotate dehydrogenase (DHODH) with an IC50 of ∼20 nM in vitro.
||Brequinar Sodium (Bipenquinate, BRQ, DUP-785, NSC 368390) is a potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of ~20 nM and triggers differentiation in the ER-HoxA9, U937, and THP1 cells with ED50 of ~1 μM.
||Brevianamide F, belonging to a class of naturally occurring 2,5-diketopiperazines, is the simplest member and the biosynthetic precursor of a large family of biologically active prenylated tryptophan-proline 2,5-diketopiperazines that are produced by the fungi A.fumigates and Aspergillus sp..
Brevifolincarboxylic acid is extracted from Polygonum capitatum, has inhibitory effect on the aryl hydrocarbon receptor (AhR). Brevifolincarboxylic acid is an α-glucosidase inhibitor with an IC50 of 323.46 μM.
||Brevilin A (6-O-Angeloylplenolina), a sesquiterpene lactone isolated from Centipeda minima, is a selective inhibitor of STAT3 and attenuates the JAKs activity by blocking the JAKs tyrosine kinase domain JH1. Brevilin A induces apoptosis and autophagy of colon adenocarcinoma cell CT26 via mitochondrial pathway and PI3K/AKT/mTOR inactivation.
||Brexpiprazole (OPC-34712) is a novel D2 dopamine and serotonin 1A partial agonist, called serotonin-dopamine activity modulator (SDAM), and a potent antagonist of serotonin 2A receptors, noradrenergic alpha 1B and 2C receptors with Ki values of 0.3, 0.12, 0.47, 0.17 and 0.59 nM for D2L, 5-HT1A, 5-HT2A, α1B receptors and α2C receptors respectivey.
||Briciclib (ON-014185) is a water soluble derivative of ON-013100, a small molecule that binds to and inhibits eukaryotic translation initiation factor 4E (eIF4E).
||Brigatinib (AP26113) is a potent and selective ALK (IC50, 0.6 nM) and ROS1 (IC50, 0.9 nM) inhibitor. It also inhibits IGF-1R, FLT3, and mutant variants of FLT3 (D835Y) and EGFR with lower potentcy.
||Brilanestrant (GDC-0810, ARN-810） is a potent ER-α binder (ER-α, IC50 = 6.1 nM; ER-β, IC50 = 8.8 nM), a full transcriptional antagonist with no agonism and displays good potency and efficacy in ER-α degradation (EC50 = 0.7 nM) and MCF-7 breast cancer cell viability (IC50 = 2.5 nM) assays with good selectivity over other nuclear hormone receptors.
||Brilliant Blue G
||Brilliant Blue G (BBG) is a potent non-competitive antagonist of P2X7 receptor with IC50 of 10.1 nM and 265 nM for rat P2X7 and human P2X7, respectively. Brilliant Blue G is a dye which is commonly used in laboratories to stain or quantify proteins.
||Brimonidine (Bromoxidine, UK 1430) is an alpha adrenergic receptor agonist (primarily alpha-2) and is used for the treatment of open-angle glaucoma or ocular hypertension to lower intraocular pressure.
||Brimonidine Tartrate is a highly selective α-adrenergic receptor agonist with EC50 of 0.45 nM for the α2A adrenoreceptor, and used to treat open-angle glaucoma or ocular hypertension.
||Brincidofovir (CMX001), the lipid-conjugated prodrug of Cidofovir (HY-17438) with long-acting antiviral effect, shows activity against a broad spectrum of DNA viruses including cytomegalovirus (CMV), adenovirus (ADV), varicella zoster virus, herpes simplex virus, polyomaviruses, papillomaviruses, poxviruses, and mixed double-stranded DNA virus infections.
||Brinzolamide (AL-4862) is a potent carbonic anhydrase II inhibitor with IC50 of 3.19 nM.
Britannilactone is a natural compound with anti-inflammatory activity.
||BRITE-338733 is a potent RecA (a DNA-dependent ATPase) inhibitor with IC50 of 4.7 µM.
||Brivanib is an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM, moderate potency against VEGFR-1 and FGFR-1, but >240-fold against PDGFR-β. Phase 3.
||Brivanib Alaninate (BMS-582664)
||Brivanib alaninate (BMS-582664) is the prodrug of BMS-540215, an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM.
||Brivudine (BVDU) is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. It is incorporated into the viral DNA and blocks the action of DNA polymerases, thus inhibiting viral replication.
||BRL-15572 is a preferential antagonist at native human 5-HT1D receptors, can be a useful tool for the differentiation between human 5-HT1B and 5-HT1D receptors in functional studies.
||BRL-15572 is a 5-HT1D receptor antagonist with pKi of 7.9, also shows a considerable affinity at 5-HT1A and 5-HT2B receptors, exhibiting 60-fold selectivity over 5-HT1B receptor.
||BRM/BRG1 ATP Inhibitor-1
||BRM/BRG1 ATP Inhibitor-1 (Compound 14) is an orally active inhibitors of Brahma Homolog (BRM)/SMARCA2 (BRG1) with IC50s below 0.005 µM.
||Brodalumab (anti-IL17RA) (KHK4827, AMG 827) is a recombinant, fully human monoclonal antibody (IgG2) which binds with high affinity to the interleukin (IL) 17 receptor A (IL17R).
||Bromfenac Sodium (AHR 10282R) is a nonsteroidal anti-inflammatory drug (NSAID), which has anti-inflammatory activity and may block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2.
||Bromfenac sodium hydrate
||Bromfenac sodium hydrate (Bromsite, Bromday, Prolensa, Xibrom), a brominated nonsteroidal anti-inflammatory drugs (NSAID) with strong in vitro anti-inflammatory potency, is a potent and orally active inhibitor of COX with IC50 of 5.56 nM and 7.45 nM for COX-1 and COX-2, respectively.
||Bromhexine is an expectorant/mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus
||Bromhexine HCl is a medication prescribed for coughs which works by dissolving hard phlegm.
||Bromisoval (Bromovalerylurea, Isobromyl, Bromaral, BRN 1773255) is a hypnotic and sedative of the bromoureide group with anti-inflammatory effects.
||Bromo-PEG1-C2-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Bromo-PEG1-CH2-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Bromo-PEG2-alcohol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Bromo-PEG2-C2-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Bromo-PEG2-CH2-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Bromo-PEG3-CH2-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Bromo-PEG4-bromide is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Bromodeoxyuridine (BrdU, 5-Bromo-2'-deoxyuridine, BUdR) is a nucleoside analog that competes with thymidine for incorporation into DNA, and used in the detection of proliferating cells.
||Bromopyruvic acid (3-Bromopyruvic acid, 3-Bromopyruvate, Bromopyruvic acid, Hexokinase II Inhibitor II, 3-BP) is a hexokinase II inhibitor with Ki of 2.4 mM for glycolysis/hexokinase inhibition. It is inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs.
||Brompheniramine hydrogen maleate
||Brompheniramine hydrogen maleate is a histamine H1 receptors antagonist.
||Bronopol (2-bromo-2-nitropropane-1,3-diol) is antibacterial agent, used as preservative in cosmetic industry.
||Broussonetiae Fructus Extract
||Brown Rice Extract
||Broxaldine (Brobenzoxaldine, AL307) is an antiprotozoal drug and can be used in leprosy.
||Broxyquinoline is an antiprotozoal agent and able to release oxygen free radicals from the water in mucous membranes.
||Brr2 Inhibitor C9
||Brr2 inhibitor C9 (Brr2 Inhibitor 9) is an allosteric inhibitor of the spliceosomal RNA helicase Brr2. Brr2 is implicated in autosomal-dominant retinitis pigmentosa a group of progressive retinal degenerative disorders.
||Brucea Javanica Extract
Bruceantinol, a quassinoid compound isolated from the fruits of <i>Brucea javanica</i>, has cytotoxic and antibacterial effects.
Bruceine D, isolated from Brucea javanica (L.) Merr. (Simaroubaceae), shows antineoplastic properties in various human cancers including pancreas, breast, lung, blood, bone, and liver. Bruceine D induces apoptosis in human chronic myeloid leukemia K562 cells via mitochondrial pathway.
||Brucine, an alkaloid closely related to strychnine, is most commonly found in the Strychnos nux-vomica tree.
||Brucine sulfate heptahydrate
||Brucine is an alkaloid that acts as an antagonist at glycine receptors and paralyzes inhibitory neurons.
||Brusatol (NSC 172924), isolated from the fruit of B. javanica, is a NRF2 inhibitor.
||BSJ-03-123 is a phthalimide-based degrader of cyclin-dependent kinase 6 (CDK6). (PROTAC)
||BSJ-4-116 is a specific degrader of cyclin-dependent kinase 12 (CDK12). BSJ-4-116 exhibits potent antiproliferative effects.
BSO (L-Buthionine-(S,R)-sulfoximine, L-Buthionine sulfoximine, l-BSO) is a cell-permeable, potent, fast acting and irreversible inhibitor of g-glutamylcysteine synthetase (γ-glutamylcysteine synthetase, γ-GCS) and depletes cellular glutathione levels. The IC50 of BSO on melanoma, breast and ovarian tumor specimens are 1.9 μM, 8.6 μM, and 29 μM, respectively.
||The combination of BSTFA and TMCS is the preferred reagent for trimethylsilylation of alcohols, alkaloids, amines, biogenic amines, carboxylic acids, phenols, and steroids. TMCS increases the reactivity of BSTFA. BSTFA-TMCS has good solvent properties and can function as a silylation reagent without additional solvents.
||BT2 is a novel branched-chain α-ketoacid dehydrogenase complex kinase (BDK) inhibitor wieh an IC50 of 3.19 μM.
||BT5 is an irreversible inhibitor of the nuclear receptor-binding SET domain protein 1 (NSD1) SET domain.
||BTB-1 is a novel, selective and reversible inhibitor of the mitotic motor protein Kif18A with IC50 of 1.69 μM.
||BTdCPU is a potent activator of heme regulated inhibitor kinase (HRI), one of eukaryotic translation initiation factor 2α kinases (eIF2α-kinases).
||BTK IN-1(SNS062 analog) is a potent Bruton's tyrosine kinase (BTK) inhibitor, with an IC50 of <100 nM.
||Btk inhibitor 2
||Btk inhibitor 2 is a BTK inhibitor.
||BTR-1 induces cytotoxicity in a time- and concentration-dependent manner on leukemia cell line CEM. BTR-1 affects DNA replication by inducing a block at S phase and leads to activation of apoptosis to induce cell death.
||BTSA1 is a pharmacologically optimized BAX activator that binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis. It effectively promotes apoptosis in leukemia cell lines and patient samples while sparing healthy cells.
||BTYNB (BTYNB IMP1 Inhibitor, MDK6620) is a potent and selective inhibitor of IMP1 binding to c-Myc mRNA. BTYNB downregulates β-TrCP1 mRNA and reduces activation of nuclear transcriptional factors-kappa B (NF-κB). BTYNB disrupts this enhancer function by impairing IGF2 mRNA-binding protein 1 (IGF2BP1)-RNA association.
||BTZ043 racemate is a decaprenylphosphoryl-β-D-ribose 2'-epimerase (DprE1) inhibitor acting as a new antimycobacterial agent that kill Mycobacterium tuberculosis.
||BTZO-1 binds to macrophage migration inhibitory factor (MIF) with Kd of 68.6 nM. BTZO-1 activats antioxidant response element (ARE)-mediated gene expression and suppresses oxidative stress-induced cardiomyocyte apoptosis in vitro.
||Bucetin is an analgesic and antipyretice agent with a risk of carcinogenesis.
||Buclizine HCl (UCB-4445) is an antihistamine and anticholinergic of the piperazine derivative family.
||Buddlejasaponin IVb (Saikosaponin 1b), a major component of Pleurospermum kamtschaticum, exerts anti-inflammatory and cytotoxic effects against cancer cells.
||Budesonide is a glucocorticoid steroid for the treatment of asthma, non-infectious rhinitis.
||Bufalin (BF) is a potent inhibitor of steroid receptor coactivator SRC-3, SRC-1 and Na+/K+-ATPase. Bufalin binds to the subunit α1, α2 and α3 of Na+/K+-ATPase with Kd of 42.5 nM, 45 nM and 40 nM, respectively. Bufalin is a major digoxin-like immunoreactive component isolated from the Chinese medicine Chan Su with anti-cancer activity.
||Bufexamac is a COX inhibitor for IFN-α release with EC50 of 8.9 μM.
||Buffalo Horn Extract
||Buflomedil HCl is a vasodilator used to treat claudication or the symptoms of peripheral arterial disease; A nonselective alpha adrenergic receptor inhibitor.
||Bufotalin, a novel anti-osteoblastoma agent, is a cardiotoxic bufanolide steroid and a cardiac glycoside analogue. Bufotalin is secreted by a number of toad species.
Bufotenidine is a naturally-occurring toxin found in frog and toad skin and plants.
||Bulevirtide (Myrcludex B)
||Bulevirtide (Myrcludex B) is a sodium-taurocholate co-transporting polypeptide (NTCP) receptor inhibitor with IC50 of ∼80 pM and inactivates NTCP function at concentrations far below those required to block bile salt transport.
||Bullatine B (Neoline) alleviates oxaliplatin-induced peripheral neuropathy in mice and can be used as a marker compound to determine the quality of the PA products for the treatment of neuropathic pain. Bullatine B is the active ingredient of processed aconite root (PA).
||Bulleyaconi cine A
||Bulleyaconi cine A (Bulleyaconitine A, BLA) is an active ingredient of Aconitum bulleyanum plants and classified as an "aconitine-like" alkaloid. It is a potent use-dependent blocker for both Nav1.7 and Nav1.8 Na+ currents.
||Bumetanide (Bumex) is a loop diuretic of the sulfamyl category to treat heart failure. Bumetanide is a selective Na+-K+-Cl- cotransporter 1 (NKCC1) inhibitor, weakly inhibits NKCC2, with IC50s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respectively.
||Bunge Auriculate Root Extract
||Buparlisib (BKM120, NVP-BKM120) is a selective PI3K inhibitor of p110α/β/δ/γ with IC50 of 52 nM/166 nM/116 nM/262 nM in cell-free assays, respectively. Reduced potency against VPS34, mTOR, DNAPK, with little activity to PI4Kβ. Buparlisib induces apoptosis. Phase 2.
||Buparvaquone (Butalex) is a second-generation hydroxynaphthoquinone related to parvaquone, with novel features that make it a promising compound for the therapy and prophylaxis of all forms of theileriosis.
||Bupivacaine HCl binds to the intracellular portion of voltage-gated sodium channels and blocks sodium influx into nerve cells, used for treating cardiac arrhythmias.
||Burdock root Extract
||Buspirone is a serotonergic (5HT(1A) receptor agonist) anxiolytic drug with some D(2) dopaminergic effect, used for anxiety disorders.
||Busulfan (NSC-750) is a cell cycle non-specific alkylating antineoplastic agent. Busulfan induces apoptosis.
||Butamben (Butyl 4-aminobenzoate) is a long-duration local anesthetic used for the treatment of chronic pain.
||Butane-1,4-diyldiphosphonic acid is an alkyl chain-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Butea Superba Extract
||Butenafine is a synthetic benzylamine antifungal agent.
||Butenafine HCl (KP-363) is a synthetic benzylamine antifungal, works by inhibiting the synthesis of sterols by inhibiting squalene epoxidase.
||Butoconazole is an imidazole antifungal used in gynecology.
||Butoconazole nitrate (RS-35887) is an anti-fungal agent that inhibits PHA-stimulated release of cytokines-- IL-2, TNFα, IFN and GM-CSF from human peripheral blood lymphocytes (IC50 of 7.2 μg/mL, 14.4 μg/mL, 7.36 μg/mL and 7.6 μg/mL, respectively).
||Butyl benzyl phthalate
||Butyl benzyl phthalate (BBP, 1,2-benzenedicarboxylic acid, butyl phenylmethyl ester) is a member of the group of chemicals known as phthalates. It is a toxicant and may be used as a plasticiser.
||Butyl isobutyl phthalate
||Butyl isobutyl phthalate (BIP), isolated from the rhizoid of Laminaria japonica, is a non-competitive inhibitor of α-glucosidase with IC50 of 38 μM. Butyl isobutyl phthalate displays a significant hypoglycemic effect and has the potential for diabetes treatment.
||Butylated hydroxytoluene (dibutylhydroxytoluene, Dibutylated hydroxytoluene, AO-29, BHT) is a lipophilic organic compound that is useful for its antioxidant properties.
||Butylparaben (Butyl parahydroxybenzoate, Butyl 4-hydroxybenzoate) is a chemical compound commonly used as an antifungal preservative in cosmetic products.
||Butylscopolamine Bromide (Scopolamine Butylbromide), is a peripherally acting antimuscarinic, anticholinergic agent used as an abdominal-specific antispasmodic.
||BVDV IN-1 is a non-nucleoside inhibitor of bovine viral diarrhea virus (BVDV), with an EC50 of 1.8 μM.
||BVT 2733, a new small molecule, is a non-steroidal, isoform-selective inhibitor of 11beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1).
||BVT-14225 is a selective inhibitor of 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) with IC50 of 52 nM.
||BVT 948 is a irreversible, noncompetitive and cell-permeable protein tyrosine phosphatase（PTP） inhibitor with IC50s of 0.9 μM, 1.7 μM, 0.09 μM, 1.5 μM and 0.7 μM for PTP1B, TCPTP, SHP-2, LAR and YopH respectively.
||BW-A78U, an adenine derivative PDE inhibitor, has anticonvulsant activity.
||BX-795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1. BX-795 modulates autophagy via inhibiting ULK1. BX-795 also is a potent TBK1 inhibitor that blocks both TBK1 and IKKε with IC 50 values of 6 nM and 41 nM, respectively.
||BX912 is a potent and specific PDK1 inhibitor with IC50 of 12 nM, 9- and 105- fold greater selectivity for PDK1 than PKA and PKC in cell-free assays, respectively. In comparison to GSK3β, selectivity for PDK1 is 600-fold.
||BX430 is a potent and selective noncompetitive allosteric antagonist of human P2X4 receptor channels with IC50 of 0.54 μM. BX430 is a potent antagonist of zebrafish P2X4 but has no effect on rat and mouse P2X4 orthologs. BX430 is used for chronic pain and cardiovascular disease.
BX471 (ZK811752, BAY 865047, SH T 04268H) is a potent nonpeptide CC chemokine receptor-1 (CCR1) antagonist with Ki values of 1 nM and 5.5 nM in both MIP-1α and MCP-3 binding to CCR1-transfected HEK293 cells, respectively.
||BX517 is a potent and selective inhibitor of PDK1 that binds to the ATP binding pocket of the protein (IC50 = 6 nM).
Byakangelicin, one of the active compounds found in the roots of Angelica gigas, can serve as a modulator to improve brain accumulation of diverse active compounds (Umb, Cur, and Dox) and enhance therapeutic effects. Byakangelicin is likely to increase the expression of all PXR target genes (such as MDR1) and induce a wide range of drug-drug interactions. Byakangelicin can inhibit the effects of sex hormones, it may increase the catabolism of endogenous hormones.
Byakangelicol is a leukotriol isolated from Angelica dahurica, which can be used in the study of airway inflammation.
||BYK204165 is a potent and selective inhibitor of the poly(ADP-ribose) polymerase (PARP). BYK204165 inhibits cell-free recombinant human PARP-1 (hPARP-1) with pIC50 of 7.35 and pKi of 7.05 and murine PARP-2 (mPARP-2) with pIC50 of 5.38, respectively.
||Bz-RS-ISer(3-Ph)-Ome is a chemical.
||BZ1, a pyridazinone-based BPTF inhibitor, possesses a high potency (Kd = 6.3 nM) and >350-fold selectivity over BET bromodomains.
BZAD01 is a GluN2B subtype-selective NMDA antagonist.
||BzATP triethylammonium salt
||BzATP triethylammonium salt acts as a P2X receptor agonist with pEC50s of 8.74, 5.26, 7.10, 7.50, 6.19, 6.31, 5.33 for P2X1, P2X2, P2X3, P2X2/3, P2X4 and P2X7, respectively, also is potent at P2X7 receptors with EC50s of 3.6 μM and 285 μM for rat P2X7 and mouse P2X7, respectively.
β-Boswellic acid is isolated from the gum resin of Boswellia serrate, which is a non-reducing type inhibitor of the 5-lipoxygenase (5-LO) product formation either interacting directly with the 5-LO or blocking its translocation.