All Products

Catalog No. Product Name Information
S7071 (+)-Bicuculline (+)-Bicuculline (d-Bicuculline) is a competitive antagonist of GABAA receptors with IC50 of 2 μM, also blocks Ca(2+)-activated potassium channels.
S3959 (+)-Borneol (+)-Borneol is one of enantiomers of borneol which is a valuable medical material, senior aromatic spice, and chemical material and has been used in food and also folk medicine.
S7099 (-)-Blebbistatin (-)-Blebbistatin ((S)-(-)-Blebbistatin) is a cell-permeable inhibitor for non muscle myosin II ATPase with IC50 of ~2 μM in cell-free assays, does not inhibit myosin light chain kinase, inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly.
S3977 (-)-Borneol (-)-Borneol (L-Borneol), one of enantiomers of borneol, has a camphoraceous and evident woody odor. (-)-Borneol has a highly efficacious positive modulating action at GABA receptor with an EC50 of 237 μM.
S6136 (±)-α-Bisabolol α-bisabolol is a small, plant-derived, oily sesquiterpene alcohol with some anti-inflammatory and even anti-microbial properties.
S1783 1,2-Bis(2-iodoethoxy)ethane 1,2-Bis(2-iodoethoxy)ethane is a PEG-based PROTAC linker. 1,2-Bis(2-iodoethoxy)ethane is applicable to the synthesis of MT802 and SJF620 which are potent PROTAC BTK degraders with DC50 of 1 nM and 7.9 nM, respectively.
S6803 1-BCP 1-BCP (Piperonylic acid piperidide) is a memory-enhancing agent that enhances AMPA-induced currents.
S6206 1-Butanol 1-Butanol occurs naturally as a minor product of the fermentation of sugars and other carbohydrates, and is present in many foods and beverages.
S5587 2,3-Benzofuran 2,3-Benzofuran is a mutagenic and carcinogenic compound.
S6040 2,3-Butanediol (mixture of isomers) 2,3-Butanediol (Dimethylene glycol, 2,3-Dihydroxybutane, Butan-2,3-diol, 2,3-Butylene glycol) is an important microbial metabolite and has been widely used in many fields such as food, medicine, chemical, and so on.
S3699 2,3-Butanedione-2-monoxime 2,3-Butanedione monoxime (BDM, Diacetyl monoxime, Diacetylmonoxime) is the well-characterized, low-affinity, non-competitive inhibitor of skeletal muscle myosin-II and inhibits skeletal and cardiac muscle contraction.
S1660 2-(Benzyloxy)ethanol 2-(Benzyloxy)ethanol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S5575 2-Benzoxazolinone 2-Benzoxazolinone (BOA, 2-Hydroxybenzoxazole), a well-known allelochemical with strong phytotoxicity, is a potential herbicidal candidate and probably functions via interfering with auxins or disrupting membrane integrity.
E0120 2-Bromohexadecanoic acid

2-Bromohexadecanoic acid (2-BP, 2-bromopalmitate) is a nonmetabolisable analogue of palmitate and acts as a palmitoylation inhibitor. 2-Bromohexadecanoic acid can directly and irreversibly inhibit the palmitoyltransferase activity of all DHHC (Asp-His-His-Cys) proteins.

S8317 3BDO 3BDO, a butyrolactone derivative, could target FKBP1A and activate the mTOR signaling pathway. It inhibits autophagy in HUVECs. 3BDO inhibits oxLDL-induced apoptosis.
S6481 3beta-hydroxy-delta5-cholenic acid 3beta-hydroxy-delta5-cholenic acid is a monohydroxy bile acid of endogenous origin. It is found in biologic fluids beginning in fetal life.
S3685 4-Biphenylacetic acid 4-Biphenylacetic acid (BPA) is a potential non-steroidal anti-inflammatory agent and forms solid inclusion complex with β-cyclodextrin. Its interaction with quinolone antibacterial agents can induce functional blockade of the γ-aminobutyric acid receptors.
S4997 4-Butylresorcinol 4-Butylresorcinol (4-n-Butylresorcinol, Rucinol) is a potent inhibitor of tyrosinase and is used in cosmetics as a depigmenting agent.
S3427 4BP-TQS 4BP-TQS is an allosteric agonist of α7 subunit-containing neuronal nicotinic acetylcholine receptors (nAChRs).
S9498 5-BDBD

5-BDBD is a potent P2X4R selective antagonist with an IC50 of 0.75 μM when applied for 2 min prior and during ATP stimulation.

S1803 5-Boc-amino-pentanoic acid 5-Boc-amino-pentanoic acid (Boc-5-aminovaleric acid, Boc-NH-C4-acid, Boc-5-Ava-OH) is a PROTAC linker that belongs to a Alkyl/ether linker. Boc-NH-C4-acid is applicable to the synthesis of PROTAC1, and specifically degrades EED, EZH2, and SUZ12 in the PRC2 Complex.
S4511 6-Benzylaminopurine 6-Benzylaminopurine is a first-generation synthetic cytokinin which could regulate the activities of the antioxidant defense system of plants.Its treatment elicits plant growth and development.
S5577 6-Biopterin 6-Biopterin ( L-Biopterin, L-Erythro-Biopterin) is a natural product that has been considered as a growth factor for some insects.
S6495 6-Bromo-2-hydroxy-3-methoxybenzaldehyde 6-Bromo-2-hydroxy-3-methoxybenzaldehyde is a bromobenzaldehyde derivative that participates in the synthesis of (±)-norannuradhapurine. 6-Bromo-2-hydroxy-3-methoxybenzaldehyde is an IRE-1α inhibitor with an IC50 of 0.08 μM.
S7857 8-Bromo-cAMP 8-bromo-cAMP (8-Br-Camp) is a cell permeable analog of cAMP that activates cyclic-AMP-dependent protein kinase with a Ka value of 0.05 μM; and a PKA activator.
A5104 B Raf Rabbit Recombinant mAb B Raf Rabbit Recombinant mAb detects endogenous levels of total B Raf.
S4920 b-AP15 b-AP15 (NSC687852) is a deubiquitinases inhibitor for 19S proteasomes activity of Ub-AMC cleavage with IC50 of 2.1 μM.
S6538 B-Raf IN 1 B-Raf IN 1 is an inhibitor of Raf wih IC50 values of 24 nM and 25 nM for B-Raf and C-Raf respectively. It is selective over 13 other kinases, including PKCα, IKKβ, and PI3Kα.
S6660 B-Raf inhibitor 1 (Compound 13) dihydrochloride B-Raf inhibitor 1 (Compound 13) is a type IIA Raf inhibitor which bind to the DFG-out conformation with ki of 1 nM,1 nM,and 0.3 nM for B-Raf(WT), B-Raf(V600E) and C-Raf, respectively.
S3428 B355252 B355252 is a neuroprotective agent potentiating nerve growth factor (NGF)-induced neurite outgrowth. B355252 protects against cell death caused by glutamate-evoked oxidative stress.
S3928 Baccatin Ⅲ Baccatin Ⅲ is a polycyclic diterpene which can be used for the semi-synthesis of paclitaxel and analogs. It exhibits immunomodulatory and anticancer chemotherapeutic activities.
A5095 BACE1 Rabbit Recombinant mAb BACE1 Rabbit Recombinant mAb detects endogenous levels of total BACE1.
S4146 Bacitracin Bacitracin is a mixture of related cyclic polypeptides produced by organisms of the licheniformis group of Bacillus subtilis var Tracy, which disrupts both gram positive and gram negative bacteria by interfering with cell wall and peptidoglycan synthesis.
S1791 Bacitracin Zinc Bacitracin is an antibiotic that interferes with the dephosphorylation of C55-isoprenyl pyrophosphate, a membrane carrier molecule that transports the building-blocks of the peptidoglycan bacterial cell wall outside of the inner membrane. It inhibits cleavage of Tyr from Met-enkephalin with IC50 of 10 μM.
S4840 Baclofen Baclofen is a gamma-amino-butyric acid (GABA) derivative used as a skeletal muscle relaxant and central nervous system depressant. It activates GABA receptors, specifically the GABAB receptors.
S1369 Bafetinib (INNO-406) Bafetinib (INNO-406, NS-187) is a potent and selective dual Bcr-Abl/Lyn inhibitor with IC50 of 5.8 nM/19 nM in cell-free assays, does not inhibit the phosphorylation of the T315I mutant and is less potent to PDGFR and c-Kit. Phase 2.
S1413 Bafilomycin A1 (Baf-A1) Bafilomycin A1(Baf-A1) is a vacuolar H+-ATPase inhibitor with IC50 of 0.44 nM. Bafilomycin A1 is found to inhibit autophagy while induces apoptosis.
A5408 Bag3 Rabbit Recombinant mAb Bag3 Rabbit Recombinant mAb detects endogenous level of total Bag3.
S8865 BAI1 BAI1 is a direct allosteric inhibitor of BAX with a dissociation constant (Kd) of 15.0 ± 4 μM.
S2268 Baicalein Baicalein is a CYP2C9 and prolyl endopeptidase inhibitor.
S2269 Baicalin (NSC-661431) Baicalin (NSC-661431) is a known prolyl endopeptidase inhibitor and affects the GABA receptors.
S9554 Bakkenolide A Bakkenolide A (Fukinanolid), extracted from Petasites tricholobus, has been suggested to against cancer and display protective effects on inflammatory cytokines formation.
S3813 Bakuchiol Bakuchiol ((S)-(+)-Bakuchiol) is a meroterpene phenol abundant in seeds and leaves of the plant Psoralea corylifolia. It has anti-inflammatory and antimicrobial activities.
S0194 Balicatib Balicatib (AAE-581) is a potent and selective inhibitor of the osteoclastic enzyme cathepsin K.
S9725 Balixafortide (POL6326)

Balixafortide (POL6326) is an orally bioavailable peptidic CXC chemokine receptor 4 (CXCR4) antagonist.

S2064 Balofloxacin Balofloxacin (Q-35) is a quinolone antibiotic, inhibiting the synthesis of bacterial DNA by interference with the enqyme DNA gyrase.
S5601 Balofloxacin Dihydrate Balofloxacin Dihydrate is an orally active fluoroquinolone antibiotic.
E0322 Balovaptan

Balovaptan (RG7314) is a highly potent and selective brain-penetrant vasopressin 1a (hV1a) receptor antagonist, with Kis of 1 nM and 39 nM for human V1a receptor and mouse mV1a receptor.

E0110 Baloxavir Baloxavir (Baloxavir acid, S-033447) is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor with an IC50 of 2.5 nM. BXA inhibits viral RNA transcription via selective inhibition of CEN activity.
S5952 Baloxavir marboxil Baloxavir marboxil, a cap-endonuclease inhibitor, is an antiviral drug.
S4842 Balsalazide Balsalazide (Colazal, Giazo), an aminosalicylate and oral prodrug, is enzymatically cleaved in the colon to produce the anti-inflammatory agent mesalazine. Balsalazide suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway.
S3745 Balsalazide disodium Balsalazide Disodium is the disodium salt form of balsalazide, an aminosalicylate and oral prodrug that is enzymatically cleaved in the colon to produce the anti-inflammatory agent mesalazine. Balsalazide Disodium suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway.
S0411 BAM 15 BAM 15 is a novel mitochondrial protonophore uncoupler capable of protecting mammals from acute renal ischemic-reperfusion injury and cold-induced microtubule damage. BAM 15 is also a potent AMPK activator. BAM 15 attenuates transportation-induced apoptosis in iPS-differentiated retinal tissue.
E0334 BAMB-4

BAMB-4 is a new membrane-permeable inhibitor of inositol-1,4,5-trisphosphate-3-kinase A((ITPKA) with IC50 of 37 μM in ADP-Glo Assay.

S4277 Bambuterol HCl Bambuterol HCl is a potent β-adrenoceptor agonist, used in the treatment of asthma.
S3840 Baohuoside I Baohuoside I (Icariside II) is a flavonoid isolated from Epimedium koreanum Nakai with anti-inflammatory and anti-cancer activities. It may exert cytotoxic effect via the ROS/MAPK pathway.
S0034 BAR501 BAR501 is a potent and selective G protein-coupled bile acid receptor 1 (GPBAR1, GPCR19, TGR5) agonist that effectively transactivates GPBAR1 in HEK293 cells overexpressing a CRE along with GPBAR1 with EC50 of 1 μM.
S0033 BAR502 BAR502 is a dual agonist with IC50 of 2 μM and 0.4 μM for FXR and GPBAR1, respectively.
S1147 Barasertib (AZD1152-HQPA) Barasertib (AZD1152-HQPA, AZD2811, INH-34) is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay, ~3700 fold more selective for Aurora B over Aurora A. Phase 1.
S6647 Bardoxolone Bardoxolone (CDDO, RTA 401), acts by releasing Nrf2 from KEAP1,is a highly potent activator of Nrf2 that induce programmed cell death (apoptosis) in cancer cells.
S8078 Bardoxolone Methyl Bardoxolone Methyl (RTA 402, TP-155, NSC 713200, CDDO Methyl Ester, CDDO-Me) is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities; Also a potent Nrf2 activator and nuclear factor-κB (NF-κB) inhibitor. Bardoxolone Methyl abrogates ferroptosis. Bardoxolone methyl induces apoptosis and autophagy in cancer cells.
S2851 Baricitinib (INCB028050) Baricitinib (LY3009104, INCB028050) is a selective JAK1 and JAK2 inhibitor with IC50 of 5.9 nM and 5.7 nM in cell-free assays, ~70 and ~10-fold selective versus JAK3 and Tyk2, no inhibition to c-Met and Chk2. Baricitinib is found to reduce or interrupt the passage of the virus into target cells and is used in the treatment research for COVID-19. Phase 3.
S5754 Baricitinib phosphate Baricitinib phosphate (INCB-028050, LY-3009104) is a selective JAK1 and JAK2 inhibitor with IC50 of 5.9 nM and 5.7 nM, ~70 and ~10-fold selective versus JAK3 and Tyk2, no inhibition to c-Met and Chk2. Baricitinib is found to reduce or interrupt the passage of the virus into target cells and is used in the treatment research for COVID-19.
S0870 Barnidipine Barnidipine (Libradin, Mepirodipine, Vasexten, YM-09730-5, Cyress, Hypoca, Oldeca) is an antihypertensive drug that belongs to the dihydropyridine (DHP) group of calcium antagonist (CaA) with Ki of 0.21 nM for [3H]nitrendipine binding sites.
S0032 Batefenterol  Batefenterol (GSK961081, TD-5959) is both a muscarinic receptor antagonist and a β2-adrenoceptor agonist with Ki of 1.4 nM, 1.3 nM and 3.7 nM for hM2, hM3 muscarinic receptors and hβ2-adrenoceptor, respectively.
S7155 Batimastat (BB-94) Batimastat (BB-94) is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3 with IC50 of 3 nM, 4 nM, 4 nM, 6 nM and 20 nM, respectively. Also inhibits the activitity of other metalloproteases, such as ADAM17.
S3982 Batyl alcohol Batyl alcohol (Batilol, Stearyl monoglyceride, 1-O-Octadecylglycerol, Batilolum), isolated from shark liver oil, is also present in yellow bone marrow of animals and has been described as an inflammatory agent.
S5469 Bavachin Bavachin (Corylifolin) is a phytoestrogen purified from natural herbal plants such as Psoralea corylifolia. It acts as a weak phytoestrogen by binding and activating the ER.
S3878 Bavachinin Bavachinin (7-O-Methylbavachin) is a novel natural pan-PPAR agonist from the fruit of the traditional Chinese glucose-lowering herb malaytea scurfpea. It shows stronger activities with PPAR-γ than with PPAR-α and PPAR-β/δ (EC50 = 0.74 μmol/l, 4.00 μmol/l and 8.07 μmol/l in 293T cells, respectively).
S8189 BAW2881 (NVP-BAW2881) BAW2881 (NVP-BAW2881) is a novel vascular endothelial growth factor (VEGF) receptor tyrosine-kinase inhibitor that potently inhibits VEGFR1-3 at 1.0-4.3 nanomolar (nM) concentrations and inhibits PDGFRβ, c-Kit, and RET (c-RET) at 45-72 nM concentrations.
S2913 BAY 11-7082 BAY 11-7082 (BAY 11-7821) is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM in tumor cells. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 with IC50 of 0.19 μM and 0.96 μM, respectively. BAY 11-7082 induces apoptosis and S phase arrest in gastric cancer cells.
S7352 Bay 11-7085 BAY 11-7085 (Bay 11-7083) is an irreversible inhibitor of TNFα-induced IκBα phosphorylation with IC50 of 10 μM.
S8215 BAY 1217389 BAY 1217389 is an orally bioavailable, selective inhibitor of the serine/threonine kinase monopolar spindle 1 (Mps1) with IC50 values below 10 nmol/L while showing an excellent selectivity profile.
S8730 BAY 1251152 BAY1251152 is a potent PTEFb/CDK9 inhibitor with an IC50 value of 3 nM for CDK9 and an at least 50-fold selectivity against other CDKs in enzymatic assays. BAY1251152 binds to and blocks the phosphorylation and kinase activity of CDK9, thereby preventing PTEFb-mediated activation of RNA Pol II and leading to the inhibition of gene transcription of various anti-apoptotic proteins.
S8530 BAY 1436032 BAY-1436032 is a highly selective, potent and orally available inhibitor of mutant Isocitrate Dehydrogenase 1 (mIDH1). It is a double-digit nanomolar and selective pan-inhibitor of the enzymatic activity of various IDH1-R132X mutants in vitro and displays potent inhibition of 2-HG release (nanomolar range) in patient derived and engineered cell lines expressing different IDH1 mutants.
S8995 BAY 2416964 BAY 2416964 (compound 192) is a potent and orally active antagonist of aryl hydrocarbon receptor (AhR) with IC50 of 341 nM. BAY 2416964 has the potential in the treatment of solid tumors.
S8128 BAY 41-2272 BAY 41-2272 is a direct and NO-independent soluble guanylate cyclase (sGC) stimulator.
S0285 Bay 41-4109 racemate BAY 41-4109 racemate (BAY41-4109 Racemic) is a mixture of R-isomer of BAY 41-4109 and S-isomer of BAY 41-4109. BAY 41-4109 an antiviral compound that inhibits human hepatitis B virus (HBV) with IC50 of 53 nM.
S0412 Bay 59-3074 Bay 59-3074 is a selective cannabinoid CB1/CB2 receptor partial agonist with Ki of 55.4 nM, 48.3 nM and 45.5 nM at rat and human CB1 and human CB2 receptors, respectively. Bay 59-3074 displays analgesic properties.
S7309 BAY 87-2243 BAY 87-2243 is a potent and selective hypoxia-inducible factor-1 (HIF-1) inhibitor. BAY 87-2243 inhibits mitochondrial complex I activity, thus triggering a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis. BAY 87-2243 exerts antitumor activity. Phase 1.
S7924 Bay K 8644 Bay K 8644 is a potent, selective activator of L-type Ca2+ channel with IC50 of 17.3 nM.
E0318 BAY-1797

BAY-1797 is a potent, orally active, and selective P2X4 antagonist, with an IC50 of 211 nM for human P2X4. BAY-1797 shows no or very weak activity on the other P2X ion channels.

S8945 BAY-1816032 BAY-1816032 is a potent and oral available inhibitor of budding uninhibited by benzimidazoles 1 (BUB1) kinase with IC50 of 6.1 nM for recombinant catalytic domain of human BUB1. BAY-1816032 has antitumor activity.
S8842 BAY-218 BAY-218 is a potent and selective small-molecule AhR inhibitor, inhibiting AhR nuclear translocation, dioxin response element (DRE)-luciferase reporter expression and AhR-regulated target gene expression induced by both exogenous and endogenous AhR ligands.
S8826 BAY-293 BAY-293 selectively inhibits the KRAS-SOS1 interaction with an IC50 of 21 nM.
S0540 BAY-474 BAY-474 is an inhibitor of tyrosine-protein kinase c-Met and can act as an epigenetics probe.
S6639 BAY-545 BAY-545 is an A2B adenosine receptor antagonist with ic50 of 59 nM.
S7006 BAY-61-3606 BAY-61-3606 is a potent and selective inhibitor of Syk kinase (Ki = 7.5 nM). BAY-61-3606 induces cell cycle arrest and apoptosis.
S8747 BAY-8002 BAY-8002 is a novel MCT1 inhibitor and potently suppress bidirectional lactate transport. BAY-8002 significantly increases intratumor lactate levels and transiently modulates pyruvate levels.
S8452 BAY-876 BAY-876 is a potent and selective GLUT1 inhibitor (IC50=0.002 μM) with a selectivity factor of >100 against GLUT2, GLUT3, and GLUT4.
S8896 BAY-885 BAY-885 is a highly potent and selective ERK5 inhibitor.
S8935 BAY-985 BAY-985 is a potent and highly selective TBK1/IKKε inhibitor. BAY-985 shows high potency toward TBK1 (IC50 = 2 nM, low ATP assay; 30 nM, high ATP assay) and IKKε(IC50 = 2 nM), as well as high potency in the mechanistic pIRF3 assay (IC50 = 74 nM), and an antiproliferative effect on SK-MEL-2 cells (IC50 = 900 nM).
S0898 BAY1082439 BAY1082439 is an orally bioavailable and selective inhibitor of PI3Kα/β/δ with anti-cancer activity. BAY1082439 also inhibits mutated forms of PIK3CA.
S8500 BAY1125976 BAY 1125976 is a selective allosteric AKT1/2 inhibitor,exhibits high efficacy on AKT signaling-dependent tumor growth in mouse models. BAY1125976 inhibits the activity of AKT1 (IC50 = 5.2 nM at 10 µM ATP and 44 nM at 2 mM ATP) and AKT2 (IC50 = 18 nM at 10 µM ATP and 36 nM at 2 mM ATP) very potently.Whereas BAY1125976 is almost inactive on AKT3 (IC50 = 427 nM at 10 µM ATP).
S2167 Bazedoxifene (TSE-424) acetate Bazedoxifene Acetate (WAY-140424, TSE-424) is a third generation selective estrogen receptor modulator (SERM).
S2128 Bazedoxifene (WAY-140424) HCl Bazedoxifene HCl (WAY-140424, TSE-424) is a novel, non-steroidal, indole-based estrogen receptor modulator (SERM) binding to both ERα and ERβ with IC50 of 23 nM and 89 nM, respectively.
S0322 BC-1215 BC-1215 is an inhibitor of F-box protein 3 (Fbxo3, a ubiquitin E3 ligase component) with IC50 of 0.9 μg/mL and LC50 of 87 μg/ml for IL-1β release. BC-1215 inhibits the Fbxo3-TRAF activation pathway by destabilizing TRAF1-6.
S9860 BC1618 BC1618 is an orally active Fbxo48 inhibitor that stimulates adenosine monophosphate (AMP)-activated protein kinase (Ampk)-dependent signaling. BC1618 promotes mitochondrial fission, facilitates autophagy and improves hepatic insulin sensitivity.
S6894 BCH BCH (2-Aminobicyclo-(2,2,1)-heptane-2-carboxylic acid, LAT1-IN-1) is a selective and competitive inhibitor of system L amino acid transporter 1 (LAT1). BCH (LAT1-IN-1) induces apoptosis in cancer cells.
S8977 BCH001 BCH001 is a specific PAPD5 inhibitor that restores telomerase activity and telomere length in dyskeratosis congenita (DC) patient induced pluripotent stem cells. PAPD5 is a noncanonical poly(A) polymerase with an unusual RNA-binding motif.
A5425 BCHE Rabbit Recombinant mAb BCHE Rabbit Recombinant mAb detects endogenous level of total BCHE.
S2837 BCI BCI ((E)-BCI, compound 1) is an allosteric dual specificity phosphatase (DUSP) inhibitor with EC50 of 13.3 μM and 8.0 μM in cells for DUSP6 and DUSP1, respectively.
S6833 BCI-121 BCI-121 is a potent inhibitor of SMYD3 that impairs the proliferation of many kinds of cancer cells.
A5078 Bcl10 Rabbit Recombinant mAb Bcl10 Rabbit Recombinant mAb detects endogenous levels of Bcl10.
S1993 BCL6-IN-7 BCL6-IN-7 (BCL6 inhibitor 7) is a potent inhibitor of BCL6 protein-protein interaction.
S6838 BCTC BCTC is an orally effective and highly potent vanilloid receptor 1 (VR1/TRPV1) antagonist. BCTC inhibits capsaicin-induced and acid-induced activation of rat VR1 with IC50 of 35 nM and 6.0 nM, respectivley. BCTC exhibits anti-tumor activity.
S0106 BD-1047 dihydrobromide BD-1047 dihydrobromide (HBr) is a selective functional antagonist of sigma-1 (σ1) receptor, shows antipsychotic activity in animal models predictive of efficacy in schizophrenia.
S0191 BD1063 2HCL BD1063 2HCL (BD1063 dihydrochloride) is a potent and selective sigma-1 receptor (σ1R) antagonist with Ki of 4.43 nM.
S0981 BD750 BD750 is an immunosuppressant and a dual inhibitor of JAK3 and STAT5 that inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation with IC50 of 1.5 μM and 1.1 μM for mouse and human T-cell proliferation, respectively.
A5077 BDNF Rabbit Recombinant mAb BDNF Rabbit Recombinant mAb detects endogenous levels of BDNF.
E0118 BDP-13176 BDP-13176 is a potent fascin 1 inhibitor with an IC50 of 240 nM.
S4472 BDP5290 BDP5290 is a potent dual inhibitor of ROCK and MRCK with IC50 of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.
S9786 BDTX-189 BDTX-189 is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations with Kd of 0.2 nM, 0.76 nM, 13 nM and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively. BDTX-189 exhibits anticancer activity.
S0489 BEBT-908 (CUDC-908) BEBT-908 (CUDC-908, PI3Kα inhibitor 1, MDK9521, PI3Kα-IN-243) is a potent selective inhibitor of PI3Kα with IC50 < 0.1 μM. BEBT-908 also inhibits HDAC with IC50 ≤ 1 μM.
S7929 BEC HCl BEC HCl is a slow-binding, and competitive arginase inhibitor with Ki of 0.31 μM (pH7.5) and 0.4-0.6 μM for Arginase II and rat Arginase I, respectively.
S5888 Beclamide Beclamide (N-Benzyl-3-chloropropionamide, beta-chlorpropionamide) exhibits sedative and anticonvulsant properties.
S3078 Beclomethasone dipropionate Beclomethasone dipropionate is a potent glucocorticoid steroid used for the treatment of rhinitis and sinusitis.
S5623 Bedaquiline Bedaquiline (TMC-207, R207910), a diarylquinoline, binds to subunit c of mycobacterial ATP synthase and inhibits its activity. It is highly selective for mycobacterial ATP synthase enzyme compared to homologous eukaryotic enzyme (Selectivity Index >20 000).
S4854 Bedaquiline fumarate Bedaquiline fumarate (TMC-207), an oral diarylquinoline, is a bactericidal antimycobacterial drug. It is a proton-translocating ATP synthetase inhibitor.
S5381 Behenic Acid Behenic Acid (docosanoic acid) is a long-chain saturated fatty acid that exists naturally as a triglyceride in canola. It act as a lubricant that helps restore the skin's natural oils and improve overall levels of hydration.
S1085 Belinostat (PXD101) Belinostat (PXD101, NSC726630, PX-105684) is a novel HDAC inhibitor with IC50 of 27 nM in a cell-free assay, with activity demonstrated in cisplatin-resistant tumors. Belinostat (PXD101) induces autophagy.
S8511 Belizatinib (TSR-011) "Belizatinib (TSR-011) is a potent inhibitor of ALK (IC50=0.7 nM) and tropomyosin receptor kinase (TRK) (IC50 values less than 3 nM for TRK A, B, and C). "
S2228 Belnacasan (VX-765) Belnacasan (VX-765) is a potent and selective inhibitor of caspase-1 with Ki of 0.8 nM in a cell-free assay. Phase 2.
S6631 Belotecan (CKD-602) hydrochloride Belotecan (CKD-602) is a potent DNA topoisomerase I inhibitor that exerts a clinical anticancer effect on various types of tumor.
S7936 Belumosudil (KD025) Belumosudil (KD025, SLx-2119) is an orally available, and selective ROCK2 inhibitor with IC50 and Ki of 60 nM and 41 nM, respectively. Phase 2.
S8853 Belvarafenib (HM95573) Belvarafenib (GDC5573, HM95573, RG6185) is a selective and orally bioavailable pan-RAF kinase inhibitor with IC50 values of 41 nM, 7 nM and 2 nM for BRAF WT, BRAF(V600E) and CRAF kinases, respectively.
S2841 Bemcentinib (R428) Bemcentinib (R428, BGB324) is an inhibitor of Axl with IC50 of 14 nM, >100-fold selective for Axl versus Abl. Selectivty for Axl is also greater than Mer and Tyro3 (50-to-100- fold more selective) and InsR, EGFR, HER2, and PDGFRβ (100- fold more selective).
S4197 Bemegride Bemegride is a central nervous system stimulant and antidote for barbiturate poisoning.
E1013 Bemnifosbuvir Hemisulfate (AT-527)

Bemnifosbuvir Hemisulfate (AT-527, RG-6422, RO 7496998) is a hemi-sulfate salt of AT-511. AT-511 is a potent inhibitor of SARS-CoV-2 with an EC90 of 0.47 μM.

S3701 Benactyzine hydrochloride Benactyzine hydrochloride is a centrally acting muscarinic antagonist. It is used as an antidepressant in the treatment of depression and associated anxiety.
S5938 Benazepril Benazepril is used to treat high blood pressure (hypertension), congestive heart failure, and chronic renal failure. Benazepril is converted into its active form benazeprilat, a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor.
S1284 Benazepril HCl Benazepril HCl (CGS 14824A) is a novel angiotensin I converting enzyme inhibitor, used primarily in treatment of hypertension.
S5939 Bendamustine (SDX105) Bendamustine (SDX105) is a nitrogen mustard drug used in the treatment of chronic lymphocytic leukemia (CLL), multiple myeloma, and non-Hodgkin's lymphoma.
S1212 Bendamustine (SDX105) HCl Bendamustine (SDX-105, Cytostasane) HCl is a DNA-damaging agent with IC50 of 50 μM in cell-free assay.
S5361 Bendazac Bendazac (bendazolic acid, AF-983) is a non-steroidal anti-inflammatory drug that delays the cataractogenic process. It may act by preventing protein denaturation.
S5867 Bendazac L-lysine Bendazac L-lysine has a protective effect against lens protein denaturation both in vitro and in vivo. It is also a nonsteroidal anti-inflammatory drug (NSAID) used for joint and muscular pain.
S3589 Bendazol Bendazol (2-Benzylbenzimidazole, Dibazol, Dibazole, Bendazole, Tromasedan) is a hypotensive drug that enhances NO synthase activity in renal glomeruli and collecting tubules. Bendazol inhibits the progression of form-deprivation myopia (FDM) and suppresses the upregulation of HIF-1α.
S4798 Benfotiamine Benfotiamine (S-Benzoylthiamine O-monophosphate) is a synthetic S-acyl derivative of thiamine (vitamin B1) and has been investigated for the treatment and prevention of Diabetic Nephropathy and Diabetes Mellitus, Type 2. Benfotiamine suppresses oxidative stress-induced NF-κB activation and prevents the bacterial endotoxin-induced inflammation.
S2017 Benidipine HCl Benidipine HCl (KW-3049) is a hydrochloride salt form of benidipine which is a dihydropyridine calcium channel blocker.
S5043 Benorylate Benorylate (Benorilate, Benoral, Benortan) is the esterification product of paracetamol and acetylsalicylic acid with anti-inflammatory, analgesic and antipyretic properties.
S5256 Benproperine phosphate Benproperine phosphate (Blascorid, Pirexyl), a cough suppressant, is an orally active, potent actin-related protein 2/3 complex subunit 2 (ARPC2) inhibitor. Benproperine phosphate attenuates the actin polymerization rate of action polymerization nucleation by impairing Arp2/3 function. Benproperine phosphate suppresses cancer cell migration and tumor metastasis.
S3515 Benpyrine racemate Benpyrine racemate ((Rac)-Benpyrine) is a potent, highly specific and orally active inhibitor of TNF-α and attenuates TNF-α-induced inflammation, thereby reducing liver and lung injury.
S2453 Benserazide HCl Benserazide HCl (Ro-4-4602) is a peripherally-acting aromatic L-amino acid decarboxylase (AAAD) or DOPA decarboxylase inhibitor.
S8867 Bentamapimod (AS602801) Bentamapimod (AS602801) is a novel, orally active JNK inhibitor with IC50 values of 80 nM, 90 nM and 230 nM for JNK1, JNK2 and JNK3 respectively.
S4388 Bentiromide Bentiromide is a peptide which is broken down in the pancreas by chymotrypsin. The bentiromide test is a test of pancreatic exocrine function.
S5626 Benzalkonium chloride Benzalkonium chloride, a detergent and preservative found in health care and household products, is an established irritant.
S4715 Benzamide Benzamide, a derivative of benzoic acid, is an inhibitor of poly(ADP-ribose) polymerase with an IC50 of 3.3 μM.
S3558 Benzamil Benzamil (Benzylamiloride), an analogue of amiloride, is a Na+/Ca2+ exhanger (NCX) inhibitor with IC50 of ~ 100 nM and an epithelial sodium channel (ENaC) blocker. Benzamil inhibits TRPP3-mediated Ca2+-activated currents with IC50 of 1.1 μM.
S5736 Benzathine penicilline Benzathine penicilline (Benzathine penicillin G) is an antibiotic useful for the treatment of a number of bacterial infections.
S4221 Benzbromarone Benzbromarone is a CYP2C9 inhibitor, it binds to CYP2C9 with Ki value of 19.3 nM.
S4725 Benzenesulfonamide Benzenesulfonamide (Benzenesulphonamide, Benzosulfonamide, Phenyl sulfonamide, Benzene sulfonamide) ia an inhibitor of carbonic anhydrases.
S4162 Benzethonium Chloride Benzethonium chloride is a potent inhibitor of nAChRs, it inhibits α4β2 nAChRs and α7 nAChRs with IC50 of 49 nM and 122 nM, respectively.
S2831 Benzetimide hydrochloride Benzetimide (R4929) hydrochloride is an antagonist of muscarinic acetylcholine receptor.
S3741 Benznidazole Benznidazole (Radanil) is a nitroimidazole derivative having an antiprotozoal activity by interfering with parasite protein biosynthesis, influencing cytokines production and stimulating host phagocytosis.
S4210 Benzocaine Benzocaine is the ethyl ester of p-aminobenzoic acid (PABA), it is a local anesthetic commonly used as a topical pain reliever or in cough drops.
S4669 Benzocaine hydrochloride Benzocaine hydrochloride (Ethyl 4-aminobenzoate, Ethyl p-aminobenzoate) is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.
S4161 Benzoic Acid Benzoic acid (FEMA 2131) is a colorless crystalline solid and a simple aromatic carboxylic acid, used as a food preservative.
S5574 Benzoic aldehyde Benzaldehyde (Benzenecarboxaldehyde, Phenylmethanal, Benzoic) is an organic compound that is frequently used in industry for chemical synthesis.
S4438 Benzophenone Benzophenone (Diphenyl ketone, Benzoylbenzene) filters out both UVA and UVB rays and is widely used in a great variety of sunscreens and personal care products.
S0944 Benzoylaconitine Benzoylaconine (Isaconitine, Pikraconitin) is an alkaloid derived from the Chinese traditional medicine Radix Aconiti Lateralis Preparata (Fuzi).
S5166 Benzoyleneurea Benzoyleneurea (2,4-Dihydroxyquinazoline, Quinazolinedione, Quinazoline-2,4-diol) scaffold is used in the synthesis of novel protein geranylgeranyltransferase-I inhibitors. Benzoyleneurea possesses anti-bacterial activity.
S0952 Benzoylhypaconine Benzoylhypaconine (Benzoylhypacoitine) is a monoester Aconitum alkaloid, the main pharmacologic and toxic component.
E0202 Benzoylmesaconine Benzoylmesaconine (Mesaconine 14-benzoate) is a main Aconitum alkaloid isolated from several Aconitum species with potent pharmacological activities, such as analgesia and anti-inflammation.
S3163 Benztropine mesylate Benztropine is a dopamine transporter (DAT) inhibitor with IC50 of 118 nM.
S4165 Benzydamine HCl Benzydamine HCl (AF864) is a topical nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, antipyretic and local anesthetic activity.
S5576 Benzyl acetate Benzyl acetate (Acetic acid benzyl ester, Benzyl ethanoate, Phenylmethyl), usually found in alcoholic beverages, is a flavouring agent.
S4600 Benzyl alcohol Benzyl alcohol (Phenylmethanol, Benzenemethanol, Phenylcarbinol, Benzoyl alcohol) is used as a local anesthetic. Also, it is used in the manufacture of other benzyl compounds, as a pharmaceutic aid, and in perfumery and flavoring.
S4599 Benzyl benzoate Benzyl benzoate (Ascabiol, Novoscabin, Scabitox, Benzoic acid benzyl ester) is one of the older preparations used to treat scabies. Scabies is a skin infection caused by the mite sarcoptes scabiei.
S5167 Benzyl cinnamate Benzyl cinnamate (Cinnamein, Benzylcinnamoate, Benzyl 3-phenylpropenoate, Cinnamic acid benzyl ester), a flavouring agent isolated from various plant species, is used in heavy oriental perfumes and as a fixative.
S4783 Benzyl isothiocyanate Benzyl isothiocyanate (BITC, Benzoylthiocarbimide, Isothiocyanic Acid Benzoyl Ester) is an isothiocyanate originally found in cruciferous vegetables that exhibits immunomodulatory, anti-parasitic, antibiotic, antioxidative, anti-atherosclerotic, anti-angiogenic, anti-metastatic, anticancer chemotherapeutic, and chemopreventive activities.
S9376 Benzylacetone Benzylacetone (4-Phenyl-2-butanone, Methyl 2-phenylethyl ketone) is an attractant compound in flowers. Benzylacetone exhibits potent and reversible antityrosinase (mushroom) activity, with IC50s of 2.8 mM and 0.6 mM for monophenolase and diphenolase, respectively.
S0406 Benzylamiloride hydrochloride Benzamil hydrochloride is a potent and specific blocker of sodium channel (ENaC).
S6015 Benzylcetyldimethylammonium chloride hydrate Benzylcetyldimethylammonium chloride hydrate is a chemical.
S6157 Benzyldimethylstearylammonium Chloride Hydrate Benzyldimethylstearylammonium Chloride Hydrate is a chemical with mild odor.
S6170 Benzyldodecyldimethylammonium Chloride Dihydrate Benzyldodecyldimethylammonium Chloride Dihydrate is a chemical.
S5206 Benzylpenicillin potassium Benzylpenicillin potassium (Penicillin G potassium) is the potassium salt form of penicillin G, a broad-spectrum penicillin antibiotic.
S4389 Bephenium Hydroxynaphthoate Bephenium is an activator of B-type Acetylcholine receptor (AChR). Bephenium selectively activates the Hco-L-AChR1 subtype made of Hco-UNC-29.1, Hco-UNC-38, Hco-UNC-63, Hco-ACR-8 subunits. Bephenium hydroxynaphthoate is an anthelmintic agent formerly used in the treatment of hookworm infections and ascariasis.
S5940 Bepotastine Bepotastine is a non-sedating, selective antagonist of the histamine 1 (H1) receptor that is indicated in allergic rhinitis, urticaria, and pruritus associated with skin disease.
S3037 Bepotastine Besilate Bepotastine Besilate (TAU 284) is a non-sedating, selective antagonist of histamine 1 (H1) receptor with pIC50 of 5.7.
S9566 Bepridil hydrochloride Bepridil hydrochloride is an anti-anginal drug classified as a calcium channel blocker. It also blocks multiple other ion channels, including sodium and potassium channels.
S9141 Berbamine Berbamine (BA), a traditional Chinese medicines extracted from Berberis amurensis (xiaoboan), is a novel inhibitor of bcr/abl fusion gene with potent anti-leukemia activity and also an inhibitor of NF-κB. Berbamine (BA) induces apoptosis in human myeloma cells and inhibits the growth of cancer cells by targeting Ca²⁺/calmodulin-dependent protein kinase II (CaMKII).
S3609 Berbamine dihydrochloride Berbamine (BA, BBM) dihydrochloride, a traditional Chinese medicines extracted from Berberis amurensis (xiaoboan), is a novel inhibitor of bcr/abl fusion gene with potent anti-leukemia activity and also an inhibitor of NF-κB. Berbamine (BA, BBM) dihydrochloride induces apoptosis in human myeloma cells and inhibits the growth of cancer cells by targeting Ca²⁺/calmodulin-dependent protein kinase II (CaMKII).
S9046 Berberine Berberine (Umbellatine), an alkaloid isolated from Rhizoma coptidis, has broad applications, particularly as an antibacterial agent in the clinic.
S2271 Berberine chloride (NSC 646666) Berberine chloride (NSC 646666, Natural Yellow 18) is a quaternary ammonium salt from the group of isoquinoline alkaloids. Berberine activates caspase 3 and caspase 8, cleavage of poly ADP-ribose polymerase (PARP) and the release of cytochrome c. Berberine chloride decreases the expression of c-IAP1, Bcl-2 and Bcl-XL. Berberine chloride induces apoptosis with sustained phosphorylation of JNK and p38 MAPK, as well as generation of the ROS. Berberine chloride is a dual topoisomerase I and II inhibitor. Berberine chloride is also a potential autophagy modulator.
S5967 Berberine chloride hydrate Berberine (Natural Yellow 18) chloride hydrate is a quaternary ammonium salt from the group of isoquinoline alkaloids. Berberine activates caspase 3 and caspase 8, cleavage of poly ADP-ribose polymerase (PARP) and the release of cytochrome c. Berberine chloride decreases the expression of c-IAP1, Bcl-2 and Bcl-XL. Berberine chloride induces apoptosis with sustained phosphorylation of JNK and p38 MAPK, as well as generation of the ROS. Berberine chloride is a dual topoisomerase I and II inhibitor. Berberine chloride is also a potential autophagy modulator.
S5440 Berberine Sulfate Berberine sulfate (Umbellatine), an alkaloid extracted from several plants, possesses antimicrobial activity against a wide variety of microorganisms including Gram-positive and Gram-negative bacteria, fungi, and protozoa.
S9237 Berberrubine Berberrubine (Beroline, 9-Berberoline), an isoquinoline alkaloid isolated from many medicinal plants, possesses diverse pharmacological activities, including glucose-lowering, lipid-lowering, anti-inflammatory, and anti-tumor effects.
S4239 Bergapten Bergapten is a psoralen that can be photoactivated and is capable of crossing-linking DNA, covalently modifying proteins and lipids, and consequently inhibiting cell replication.
S9442 Bergaptol Bergaptol (5-Hydroxypsoralen, 5-Hydroxyfuranocoumarin) is a natural furanocoumarin found in the essential oils of citrus including lemon and bergamot.Bergaptol is a potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 μM.
S2270 Bergenin Bergenin (Cuscutin) is trihydroxybenzoic acid glycoside and the C-glycoside of 4-O-methyl gallic acid.
S5941 Besifloxacin Besifloxacin is a fourth generation fluoroquinolone-type opthalmic antibiotic for the treatment of bacterial conjunctivitis.
S3055 Besifloxacin HCl Besifloxacin HCl is a fourth-generation fluoroquinolone antibiotic.
S6729 Besifovir Besifovir is novel and potent acyclic nucleotide phosphonate used to treat hepatitis B virus (HBV) infection.
S1591 Bestatin (NK421) Bestatin (NK421, Ubenimex) is a potent aminopeptidase-B and leukotriene (LT) A4 hydrolase inhibitor, used in the treatment of acute myelocytic leukemia.
S2939 BET bromodomain inhibitor BET bromodomain inhibitor is a potent BET inhibitor.
A5461 Beta 2 Adrenergic Receptor Rabbit Recombinant mAb Beta 2 Adrenergic Receptor Rabbit Recombinant mAb detects endogenous level of total Beta 2 Adrenergic Receptor.
A5538 Beta Actin Rabbit Recombinant mAb Beta Actin Rabbit Recombinant mAb detects endogenous level of total Beta Actin.
S1767 Beta Carotene Beta Carotene is an organic compound and classified as a terpenoid. It is a precursor (inactive form) of vitamin A.
A5038 Beta Catenin Rabbit Recombinant mAb

Beta Catenin Antibody detects endogenous levels of total beta Catenin.

A5107 beta Tubulin III Rabbit Recombinant mAb beta Tubulin III Rabbit Recombinant mAb detects endogenous levels of total beta Tubulin III.
A5167 Beta Tubulin Rabbit Recombinant mAb (HRP conjugated) Beta Tubulin Rabbit Recombinant mAb (HRP conjugated) detects endogenous level of total beta tubulin.
S9118 Beta-Asarone Beta-Asarone, found in certain plants such as Acorus and Asarum, could pass the blood-brain barrier and exerts neuroprotection effects.
S9408 Beta-Elemonic acid Beta-Elemonic acid (3-Oxotirucallenoic Acid), a known triterpene isolated from Boswellia (Burseraceae), exhibits anti‑inflammatory effects.
S7261 Beta-Lapachone Beta-Lapachone (β-Lapachone, ARQ-501) is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II or ligase. Phase 2.
S5619 Betahistine Betahistine is an antivertigo drug that primarily acts as a histamine H1 agonist.
S3176 Betahistine 2HCl Betahistine (PT-9) is a histamine H3 receptor inhibitor with IC50 of 1.9 μM.
S0217 Betahistine EP Impurity C (NSC19005) Betahistine EP Impurity C (NSC19005) is structurally related to Betahistine and is a dimer of Betahistine. It is used as a reagent in the preparation of copper pyridylmethylethylenediamine dicyanamido polymeric complexes.
S5498 Betahistine mesylate Betahistine mesylate is the mesylate salt form of Betahistine, a histamine analog and H3 receptor agonist that serves as a vasodilator.
S3755 Betaine Betaine (trimethylglycine, glycine betaine, lycine, oxyneurine), a methyl derivative of glycine first isolated from sugar beets, has been shown to have potential benefits for fighting heart disease, improving body composition, and helping promote muscle gain and fat loss because of its abilities to promote protein synthesis in the body.
S1500 Betamethasone Betamethasone (NSC-39470, SCH-4831) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.
S6375 Betamethasone 21-valerate Betamethasone 21-valerate can be metabolised into betamethasone by skin esterases. Betamethasone Valerate is effective and safe in the treatment of patchy alopecia areata (AA).
S1688 Betamethasone Dipropionate Betamethasone Dipropionate (SCH 11460) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive abilities.
E0174 Betamethasone sodium phosphate

Betamethasone sodium phosphate (Betamethasone 21-Phosphate Disodium Salt) is a potent glucocorticoid with anti-inflammatory activity.

S1690 Betamethasone Valerate Betamethasone Valerate is a moderately potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.
S4191 Betamipron Betamipron (CS-443) is a chemical compound which is used together with panipenem to inhibit panipenem uptake into the renal tubule and prevent nephrotoxicity.
S2091 Betaxolol Betaxolol (SL 75212) is a selective beta1 adrenergic receptor blocker used in the treatment of hypertension and glaucoma.
S1827 Betaxolol HCl Betaxolol (SL 75212) is a β1 adrenergic receptor blocker with IC50 of 6 μM.
S6612 Betazole Dihydrochloride Betazole Dihydrochloride (Ametazole, 2-(3-Pyrazolyl)ethanamine) is a histamine H2 agonist used clinically to test gastric secretory function.
S2455 Bethanechol chloride Bethanechol chloride is a selective muscarinic receptor agonist without any effect on nicotinic receptors.
S5388 Betrixaban Betrixaban is a new, long-acting, oral and selective Factor Xa inhibitor that decreases prothrombinase activity and thrombin generation.
S5389 Betrixaban maleate Betrixaban maleate is the maleate salt form of Betrixaban, which is a Factor Xa inhibitor that decreases prothrombinase activity and thrombin generation.
S4754 Betulin Betulin (BE, betulinol, betuline, betulinic alcohol), also known as betulinol, betuline, or betulinic alcohol, is a pentacyclic lupane-type triterpenoid naturally distributed in many plants and displays a broad spectrum of biological and pharmacological properties such as anticancer and chemopreventive activity. Betulin (Trochol), is a sterol regulatory element-binding protein (SREBP) inhibitor with an IC50 of 14.5 μM in K562 cell line.
S3603 Betulinic acid Betulinic acid (ALS-357, Lupatic acid, Betulic acid), a pentacyclic triterpenoid from Syzigium claviflorum, is a inhibitor of HIV-1 with EC50 of 1.4 μ M. Betulinic acid acts as a new activator of NF-kB.Phase 1/2.
S9153 Betulinicaldehyde Betulinicaldehyde (Betulinal, Betunal), isolated from the bark of tectona grandis., is an anti-tumor agent.
S3900 Betulonic acid Betulonic acid (Liquidambaric acid), derived from betulinol, a pentacyclic styrene, has shown a highly specific anti-prostate cancer activity in in vitro cell cultures.
A2006 Bevacizumab (anti-VEGF) Bevacizumab (anti-VEGF, Avastin) is a humanized anti-VEGF monoclonal antibody which binds to and neutralizes all human VEGF-A isoforms and bioactive proteolytic fragments, MW:149 KD.
S5042 Bevantolol hydrochloride Bevantolol hydrochloride (NC-1400) is a cardioselective, beta adrenoceptor antagonist, devoid of intrinsic β sympathomimetic activity and with weak membrane-stabilizing and local anesthetic properties.
S9010 Bevirimat Bevirimat (MPC-4326, PA-457, YK-FH312), the prototype Human Immunodeficiency Virus type 1 (HIV-1) maturation inhibitor, is highly potent in cell culture and efficacious in HIV-1 infected patients.
E0141 Bexagliflozin (EGT1442)

Bexagliflozin (EGT1442, EGT-0001442, THR-1442) is a potent and selective SGLT2 inhibitor with an IC50 of 2 nM.

S2098 Bexarotene (LGD1069) Bexarotene (Targretin, LGD1069) is a retinoid specifically selective for retinoid X receptors, used as an oral antineoplastic agent in the treatment of cutaneous T-cell lymphoma.
S4159 Bezafibrate Bezafibrate (BM 15075) is the first clinically tested dual and pan-PPAR co-agonism.
S8188 BFH772 BFH772 is a novel potent oral VEGFR2 inhibitor, targeting VEGFR2 kinase with IC50 of 3 nM.
S0264 BFMO (biogenic Fe-Mn oxides) BFMO (biogenic Fe-Mn oxides, defined as a mixture of biogenic Mn oxide (BMO) and Fe oxide) could eliminate or decrease Fe(II), Mn(II), and As(III&V) species simultaneously. BFMO can be used for As removal from water containing high concentrations of Fe(II) and Mn(II).
S8370 BGP-15 2HCl BGP-15, is a nicotinic amidoxime derivative with PARP inhibitory activity. It has been demonstrated that BGP-15 protects against ischemia-reperfusion injury.
S2749 BGT226 (NVP-BGT226) maleate BGT226 (NVP-BGT226) maleate is a novel class I PI3K/mTOR inhibitor for PI3Kα/β/γ with IC50 of 4 nM/63 nM/38 nM. Phase 1/2.
S3628 BHQ BHQ (2,5-di-t-butyl-1,4-benzohydroquinone) is a potent and selective inhibitor of the sarco-endoplasmic reticulum Ca2+-ATPase (SERCA).
S0073 BI 01383298 BI 01383298 is a potent and selective inhibitor of the sodium-citrate co-transporter (SLC13A5) with IC50 of 56 nM and 24 nM in HEK cells and HepG2 cells, respectively.
S1109 BI 2536 BI-2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. BI-2536 inhibits Bromodomain 4 (BRD4) with Kd of 37 nM and potently suppresses c-Myc expression. BI-2536 induces apoptosis and attenuates autophagy. Phase 2.
S8574 BI 894999 BI 894999 is a potent and selective BET inhibitor with IC50 of 5 nM and 41 nM for the binding of BRD4-BD1 and BRD4-BD2 to acetylated histones, respectively. BI 894999 is highly selective for BRD2/3/4 and BRDT (Kd of 0.49-1.6 nM), with at least a 200-fold selectivity vs. BRD4-BD1.
S0367 BI SF3 BI SF3 is an active compound.
S1058 BI-1347 BI-1347 is small molecule inhibitor of Cyclin-dependent kinase 8(CDK8) with IC50 of 1.1 nM.
S8959 BI-2852 BI-2852 is a potent inhibitor of KRAS that binds with nanomolar affinity to a pocket between switch I and II on RAS. BI-2852 blocks all GEF, GAP, and effector interactions with KRAS, leading to inhibition of downstream signaling and an antiproliferative effect in the low micromolar range in KRAS mutant cells.
S8916 BI-3406 BI-3406 (compound I-13) is a potent, selective and orally active inhibitor of the interaction between KRAS and Son of Sevenless 1 (SOS1) with IC50 of 5 nM. BI-3406 reduces the formation of GTP-loaded KRAS, and inhibits MAPK pathway signaling. BI-3406 exhibits anti-tumor activities.
S6937 BI-3802 BI-3802 is a highly potent oncogenic transcription factor BCL6 degrader with strong de-repression of target genes anti-proliferative effects. BI-3802 inhibits the BTB domain of BCL6 with IC50 of ≤3 nM. BI-3802 exhibits antitumor activity.
S8735 BI-3812 BI-3812 is a highly potent and efficacious BCL6 inhibitor probe compound with an IC50 less than 3 nM.
S8921 BI-4020 BI-4020 is an orally active, non-covalent EGFR inhibitor with IC50 of 0.6 nM and 0.2 nM for EGFRdel19 T790M C797S as biomarker potency and anti-proliferation potency in BaF3 cells, respectively.
S0039 BI-409306 BI 409306 (SUB 166499) is a potent and selective inhibitor of human and rat PDE9A with mean IC50 of 65 nM and 168 nM, respectively. Treatment with BI 409306 increases brain cGMP levels, promotes long-term potentiation, and improves episodic and working memory performance in rodents.
S6545 BI-4464 BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM.
S0495 BI-671800 BI-671800 (AP-761, Cmpd A) is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2) with IC50 of 4.5 nM and 3.7 nM for PGD2 binding to human CRTH2 and murine CRTH2, respectively. BI-671800 is associated with a small improvement in FEV1 in symptomatic controller-naïve asthma patients, and in patients on ICS.
S6393 BI-749327 BI-749327 is a potent, selective and orally bioavailable antagonist of TRPC6 with IC50 of 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6, respectively.
S7843 BI-847325 BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Phase 1.
S2843 BI-D1870 BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B. BI-D1870 exhibits anticancer attributes including the generation of reactive oxygen species (ROS) and increases in endoplasmic reticulum (ER) stress and autophagy.
S5932 BIA 10-2474 BIA 10-2474 is a novel fatty acid amide hydrolase (FAAH) inhibitor, with a potent inhibitory effect upon FAAH and prolonged action in vivo.
S1370 Biapenem Biapenem (L-627, LJC10627) is a carbapenem antibiotic with activity against both Gram-positive and Gram-negative bacterial strains.
S2234 BIBF-0775 BIBF-0775 is a selective inhibitor of transforming growth factor β Receptor I (TGFβRI,Alk5) with an IC50 of 34nM.
E0014 BIBO 3304 Trifluoroacetate

BIBO 3304 Trifluoroacetate (BIBO-3304 TFA) is a novel neuropeptide Y Y1 receptor (NPY1R) antagonist with IC50 values of 0.38 nM and 0.72 nM for human Y1 receptor and rat Y1 receptor, respectively. BIBO 3304 shows low affinity for the human Y2 receptor, human and rat Y4 receptor as well as for the human and rat Y5 receptor (IC50 values >1000 nM).

S1186 BIBR 1532 BIBR 1532 is a potent, selective, non-competitive telomerase inhibitor with IC50 of 100 nM in a cell-free assay. No inhibition of DNA and RNA polymerases, including HIV reverse transcriptase are observed at concentrations vastly exceeding the IC50 for telomerase. BIBR 1532 induces apoptosis in cancer cells.
S1190 Bicalutamide (ICI-176334) Bicalutamide (ICI-176334) is an androgen receptor (AR) antagonist with IC50 of 0.16 μM in LNCaP/AR(cs)cell line. Bicalutamide promotes autophagy.
S6276 Bicine Bicine (N,N-Bis(2-hydroxyethyl)glycine, Diethylolglycine, Diethanol glycine, Dihydroxyethylglycine) is an organic compound used as a buffering agent.
S5911 Bictegravir Bictegravir (GS-9883) is a novel, potent, once-daily, unboosted inhibitor of HIV-1 integrase.
E0161 Bictegravir Sodium

Bictegravir (GS-9883) Sodium is a novel and potent inhibitor of HIV-1 integrase, specifically targets IN strand transfer activity with an IC50 of 7.5 nM.

S6453 Bicyclol Bicyclol (SY-801) is a drug that can improve liver function and inhibit HBV replication.
S5985 Bifemelane hydrochloride (MCI-2016) Bifemelane hydrochloride (MCI-2016) is a potent, selective and competitive monoamine oxidase A (MAO-A) inhibitor with Ki of 4.20 μM and a noncompetitive inhibitor of MAO-B with Ki of 46.0 μM. Bifemelane hydrochloride exhibits potent antidepressant activity and can be used for the research of cognitive and emotional disturbances related to cerebrovascular disease.
S4890 Bifendate Bifendate, a synthetic intermediate of schisandrin C, is an anti-HBV drug used in Chinese medicine for the treatment of chronic hepatitis B.
S1854 Bifonazole Bifonazole (Bay h 4502) is a substituted imidazole antifungal agent.
S3571 BIIB-068 BIIB068 is a potent, selective, reversible and orally active inhibitor of BTK with IC50 of 1 nM and Kd of 0.3 nM, respectively.
S1175 BIIB021 BIIB021 (CNF2024) is an orally available, fully synthetic small-molecule inhibitor of HSP90 with Ki and EC50 of 1.7 nM and 38 nM, respectively. Phase 2.
S3721 Bilastine Bilastine is a new, well-tolerated, nonsedating H1 receptor antihistamine and has a rapid onset and prolonged duration of action.
S5116 Bilibubin Bilibubin (Bilirubin) is a tetrapyrrole and a breakdown product of heme catabolism that acts as a physiological, chain-breaking antioxidant.
S2276 Bilobalide Bilobalide is a biologically active terpenic trilactone present in Ginkgo biloba.
S1407 Bimatoprost Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension.
S8738 Bimiralisib (PQR309) Bimiralisib (PQR309) is a novel brain-penetrant dual PI3K/mTOR inhibitor with in vitro and in vivo antilymphoma activity. It displays excellent selectivity versus PI3K-related lipid kinases, protein kinases and unrelated targets.
S3032 Bindarit (AF 2838) Bindarit (AF 2838) exhibits selective inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.
S7007 Binimetinib (MEK162) Binimetinib (MEK162, ARRY-162, ARRY-438162) is a potent inhibitor of MEK1/2 with IC50 of 12 nM in a cell-free assay. Binimetinib induces G1 cell cycle arrest and apoptosis in human NSCLC cell lines and induces autophagy. Phase 3.
S7198 BIO BIO (GSK-3 Inhibitor IX, 6-bromoindirubin-3-oxime, 6-Bromoindirubin-3'-oxime, MLS 2052) is a specific inhibitor of GSK-3 with IC50 of 5 nM for GSK-3α/β in a cell-free assay, shows >16-fold selectivity over CDK5, also a pan-JAK inhibitor with IC50 of 30 nM for Tyk2. BIO induces apoptosis in human melanoma cells.
S7915 BIO-acetoxime BIO-acetoxime (GSK-3 Inhibitor X) is a potent dual GSK3α/β inhibitor with IC50 of 10 nM, >240-fold selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B.
L1700 Bioactive Compound Library-I A unique collection of 8273 bioactive compounds for high throughput screening (HTS) and high content screening (HCS).
L1700-Ⅱ Bioactive Compound Library-Ⅱ A unique collection of 5309 bioactive compounds for high throughput screening (HTS) and high content screening (HCS).
S2377 Biochanin A Biochanin A (4-Methylgenistein), an O-methylated isoflavone from Trifolium pratense, inhibits protein tyrosine kinase (PTK) of epidermal growth factor receptor with IC50 values of 91.5 μM.
S9886 Biocytin Biocytin ((+)-Biocytin, Biotinyl-L-lysine) is a conjugate of D-biotin and L-lysine. Biocytin is an attractive neuronal tracer. It labels neurons fast over long distances, and it can be used in conjunction with calcium dyes to report on neuronal activity in retrogradely labeled live neurons.
S0995 BioE-1115 BioE-1115 is a highly selective and potent dual inhibitor of PAS kinase (PASK) and casein kinase 2α (CK2α) with IC50 of ~4 nM and ~10 μM, respectively.
S3130 Biotin (Vitamin B7) Biotin is a water-soluble B-vitamin and is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids.
S1596 Biotin-PEG4-acid Biotin-PEG4-acid is a PEG-based PROTAC linker that is applicable to the synthesis of PROTAC.
S1365 Biotin-PEG6-alcohol Biotin-PEG6-alcohol is a biotin-labeled and PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1947 Biotin-PFP ester Biotin-PFP ester is an alkyl/ether-based PROTAC linker that is applicable to the synthesis of PROTACs.
S6318 Biotinyl Tyramide

Biotinyl Tyramide is a biotin derivative used for signal amplification in IHC and fluorescent in situ hybridization (ISH).

E0362 BiP Inducer X (BIX)

BiP Inducer X (BIX) is a selective GRP78 (BiP, HSPA5) inducer. BIX induces BiP only, in a dose-dependent manner, without induction of other molecules involved in the ER stress response.

S5438 Biphenyl-4-sulfonyl chloride Biphenyl-4-sulfonyl chloride (p-Phenylbenzenesulfonyl, 4-Phenylbenzenesulfonyl, p-Biphenylsulfonyl) is a HDAC inhibitor with synthetic applications in palladium-catalyzed desulfitative C-arylation.
S7360 Birabresib (OTX015) Birabresib (OTX015, MK 8628) is a potent BET bromodomain inhibitor with EC50 ranging from 10 to 19 nM for BRD2, BRD3, and BRD4 in cell-free assays. Birabresib inhibits the expression of Nuclear receptor binding SET domain protein 3 (NSD3) target genes.
S7015 Birinapant (TL32711) Birinapant (TL32711) is a SMAC mimetic antagonist, mostly to cIAP1 with Kd of <1 nM in a cell-free assay, less potent to XIAP. Birinapant helps to induce apoptosis in latent HIV-1-infected cells. Phase 2.
S3360 Bis(2-ethylhexyl) phthalate

Bis(2-ethylhexyl) phthalate (Dioctyl phthalate, DOP, Diplast O, ESBO-D 82, Ergoplast FDO, Ergoplast FDO-S, Etalon) induces DNA strand breaks and gene expression alterations in larval zebrafish Danio rerio.

S6314 Bis(2-methyl-3-furyl)disulphide Bis(2-Methyl-3-furyl) disulfide is a volatile sulfur compound that is a key contributor to the meat-like aroma in cooked meat.
S1772 Bis-NH2-C1-PEG3 Bis-NH2-C1-PEG3 is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1347 Bis-NH2-PEG2 Bis-NH2-PEG2 is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S0623 Bis-PEG1-NHS ester Bis-PEG1-NHS ester is a non-cleavable 1-unit PEG linker for antibody-drug-conjugation (ADC).
S1350 Bis-PEG3-acid Bis-PEG3-acid is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S0693 Bis-PEG3-NHS ester Bis-PEG3-NHS ester is a non-cleavable 3-unit PEG linker that can be used for antibody-drug-conjugation (ADC).
S0694 Bis-PEG5-NHS ester Bis-PEG5-NHS ester is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0689 Bis-PEG8-acid Bis-PEG8-acid is a PEG-based PROTAC linker can be applied into the synthesis of PROTACs. Bis-PEG8-acid is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S1781 Bis-Tos-PEG4 Bis-Tos-PEG4 is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1769 Bis-Tos-PEG6 Bis-Tos-PEG6 is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S0638 Bis-​PEG2-​NHS ester Bis-PEG2-NHS ester is a non-cleavable 2-unit PEG linker used for antibody-drug-conjugation (ADC).
S0613 Bis-​PEG4-​NHS ester Bis-​PEG4-​NHS ester is a noncleavable 4-unit PEG linker for antibody-drug-conjugation (ADC).
S4047 Bisacodyl Bisacodyl (INN) is a stimulant laxative drug that works directly on the colon to produce a bowel movement.
S3938 Bisdemethoxycurcumin (BDMC) Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin and possesses several biological activities, such as anti-inflammation and anti-cancer activities.
S7208 Bisindolylmaleimide I (GF109203X) Bisindolylmaleimide I (GF109203X, GO 6850) is a potent PKC inhibitor with IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ in cell-free assays, respectively, showing more than 3000-fold selectivity for PKC as compared to EGFR, PDGFR and insulin receptor.
S0754 Bisindolylmaleimide IV Bisindolylmaleimide IV (Arcyriarubin A, BIM IV, Compound 5/1a) is a potent inhibitor of protein kinase C (PKC) with IC50 of 0.55 μM. Bisindolylmaleimide IV also inhibits PKA with IC50 of 11.8μM. Bisindolylmaleimide IV is a potent, selective inhibitor of human cytomegalovirus (HCMV) replication in cell culture with IC50 of 0.2 μM.
S4093 Bismuth Subcitrate Potassium Bismuth Subcitrate is an antibiotic used to treat stomach ulcers associated with Helicobacter pylori, a bacterial infection.
S4032 Bismuth Subsalicylate Bismuth Subsalicylate is the active ingredient in Pepto-Bismol and inhibits prostaglandin G/H Synthase 1/2.
S4551 Bisoctrizole Bisoctrizole (Tinosorb M, Tinuvin-360, UV-360, Milestab-360) is a broad-spectrum ultraviolet radiation absorber, absorbing UVB as well as UVA rays. Also a hybrid UV absorber, reflecting and scattering UV.
S5942 Bisoprolol Bisoprolol is a cardioselective β1-adrenergic blocking agent used for secondary prevention of myocardial infarction (MI), heart failure, angina pectoris and mild to moderate hypertension.
S1206 Bisoprolol fumarate Bisoprolol fumarate (EMD33512) is a selective type β1 adrenergic receptor blocker.
S6007 Bisphenol A Bisphenol A is a starting material for the synthesis of plastics, primarily certain polycarbonates and epoxy resins, as well as some polysulfones and certain niche materials. It exhibits estrogen-mimicking, hormone-like properties.
S4552 Bithionol Bithionol (Actamer) is a potent inhibitor of soluble adenylyl cyclase(sAC) with an IC50 of 4 μM and has antibacterial and anthelmintic properties along with algaecide activity.
S8219 Bitopertin Bitopertin (RG1678,RO-4917838) is a potent inhibitor of glycine transporter 1 (GlyT1), with Ki of 8.1 nM for human hGlyT1b and IC50 of 22-25 nM in Chinese hamster ovary cells.
P1004 Bivalirudin Trifluoroacetate Bivalirudin Trifluoroacetate is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin.
S8006 BIX 01294 BIX01294 is an inhibitor of G9a histone methyltransferase with IC50 of 2.7 μM in a cell-free assay, reduces H3K9me2 of bulk histones, also weakly inhibits GLP (primarily H3K9me3), no significant activity observed at other histone methyltransferases. BIX01294 induces autophagy. BIX01294 also inhibits H3K36 methylation by oncoproteins NSD1, NSD2 and NSD3.
S1531 BIX 02189 BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM, also inhibits ERK5 catalytic activity with IC50 of 59 nM in cell-free assays, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2.
S0819 BL-918 BL-918 is a potent, orally active activator of UNC-51-like kinase 1 (ULK1) with EC50 of 24.14 nM and Kd of 0.719 μM. BL-918 induces cytoprotective autophagy for Parkinson's disease treatment.
S6339 Black PN Black PN (Brilliant Black BN) is a black dye that provides a blackish violet shade in applications.
S7419 Blasticidin S HCl Blasticidin S HCl is a nucleoside antibiotic isolated from Stretomyces girseochromogenes, and acts as a DNA and protein synthesis inhibitor, used to select transfected cells carrying bsr or BSD resistance genes.
S1214 Bleomycin (NSC125066) sulfate Bleomycin Sulfate (NSC125066) is a glycopeptide antibiotic and an anticancer agent for squamous cell carcinomas (SCC) with IC50 of 4 nM in UT-SCC-19A cells.
S9481 Blinin Blinin, isolated from the whole plant of Conyza blinii, is used in folk medicine in the south-west of China.
S2112 Blonanserin Blonanserin (AD 5423) is a relatively selective serotonin (5-HT)2A and dopamine D2 antagonist, used the treatment of schizophrenia.
S0857 BLT-1 BLT-1 is an inhibitor of HDL receptor SR-BI. BLT-1 is primarily used for phosphorylation and dephosphorylation applications.
S7819 BLU9931 BLU9931 is a potent, selective, and irreversible FGFR4 inhibitor with IC50 of 3 nM, about 297-, 184-, and 50-fold selectivity over FGFR1/2/3, respectively.
S7725 BLZ945 BLZ945 is an orally active, potent and selective CSF-1R inhibitor with IC50 of 1 nM, >1000-fold selective against its closest receptor tyrosine kinase homologs.
S0455 BM212 BM212 is a potent inhibitor of the intracellular mycobacteria, exerting bactericidal activity against intracellular bacilli residing.
S2854 BML-190 BML-190 (IMMA) is a selective cannabinoid CB2 receptor inverse agonist with Ki of 435 nM, with 50-fold selectivity over CB1 receptor.
S1073 BML-210 (CAY10433) BML-210 (CAY10433) is a small molecule inhibitor of HDAC.BML-210 inhibits the HDAC4-VP16-driven reporter signal in a dose-dependent manner with an apparent IC50 of ∼5 µM.
S2255 BMOV BMOV (Bis maltolato oxovanadium, Bis(maltolato)oxovanadium (IV)) is a potent oral vanadium complex with anti-diabetic properties and insulin-mimicking effects.BMOV is shown to improve cardiac dysfunctions in diabetic models.
S0582 BMPS BMPS is a noncleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S7911 BMS-1 (PD-1/PD-L1 inhibitor 1) BMS-1 (PD-1/PD-L1 inhibitor 1, PD1-PDL1-IN1) is a small-molecule inhibitor of PD-1/PD-L1 interaction with IC50 of 6 nM.
S9610 BMS-1001 BMS-1001 is a potent inhibitor of PD-1/PD-L1 interaction with EC50 of 253 nM. BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes.
S8859 BMS-1166 BMS-1166 is a novel and potent small molecule inhibitor of the PD-1/PD-L1 interaction with an IC50 of 1.4 nM.
S3413 BMS-191011 BMS-191011 (BMS-A), an opener of large-conductance Ca2+-activated potassium channels, dilates rat retinal arterioles in vivo.
S2014 BMS-265246 BMS-265246 is a potent and selective CDK1/2 inhibitor with IC50 of 6 nM/9 nM in a cell-free assay. It is 25-fold more selective for CDK1/2 than CDK4.
S3525 BMS-3 BMS-3 is a potent inhibitor of LIM kinases (LIMKs) with IC50 of 5 nM and 6 nM for LIMK1 and LIMK2, respectively.
S8044 BMS-345541 BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM in cell-free assays, respectively.
S2632 BMS-378806 BMS-378806 (BMS 806) selectively inhibits the binding of HIV-1 gp120 to the CD4 receptor with EC50 of 0.85-26.5 nM in virus.
S0185 BMS-5 BMS-5 (LIMKi 3) is a potent inhibitor of LIM kinases (LIMK) with IC50 of 7 nM and 8 nM for LIMK1 and LIMK2, respectively.
S1012 BMS-536924 BMS-536924 (CS-0117) is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for Akt1, MAPK1/2.
S8124 BMS-582949 BMS-582949 (PS540446) is a potent and selective p38 mitogen-activated protein kinase (p38 MAPK) inhibitor with IC50 of 13nM,inhibiting both p38 kinase activity and activation of p38.
S0170 BMS-687453 BMS-687453 (compound 2) is a potent and selective agonist of PPARα with EC50 of 10 nM and IC50 of 260 nM for human PPARα.
S1366 BMS-707035 BMS-707035 is a specific HIV-I integrase (IN) inhibitor with IC50 of 15 nM. Phase 2.
S1124 BMS-754807 BMS-754807 is a potent and reversible inhibitor of IGF-1R/InsR with IC50 of 1.8 nM/1.7 nM in cell-free assays, less potent to Met (c-Met), Aurora A/B, TrkA/B and Ron, and shows little activity to Flt3, Lck, MK2, PKA, PKC etc. Phase 2.
S1561 BMS-777607 BMS-777607 (BMS 817378) is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3 with IC50 of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM in cell-free assays, 40-fold more selective for Met-related targets versus Lck, VEGFR-2, and TrkA/B, and more than 500-fold greater selectivity versus all other receptor and non receptor kinases. Phase 1/2.
S2201 BMS-794833 BMS-794833 is a potent ATP competitive inhibitor of Met (c-Met)/VEGFR2 with IC50 of 1.7 nM/15 nM, also inhibits Ron, Axl and Flt3 with IC50 of <3 nM; a prodrug of BMS-817378. Phase 1.
S0085 BMS-813160 BMS-813160 is a potent, well-absorbed dual CCR2 and CCR5 chemokine antagonist. BMS-813160 inhibits inflammatory processes, angiogenesis, tumor cell migration, tumor cell proliferation and invasion.
S7138 BMS-833923 BMS-833923 (XL139) is an orally bioavailable Smoothened antagonist. Phase 2.
S7144 BMS-911543 BMS-911543 is a potent and selective inhibitor of JAK2 with IC50 of 1.1 nM, ~350-, 75- and 65-fold selective to JAK1, JAK3 and TYK2, respectively. Phase 1/2.
S8348 BMS-935177 BMS-935177 is a potent, reversible Bruton's Tyrosine Kinase (BTK) inhibitor with an IC50 value of 2.8 nM and demonstrates good kinase selectivity. It is more potent against BTK than other kinase, including the other Tec family kinases (TEC, BMX, ITK, and TXK) over which the compound is between 5- and 67-fold selective.
S3572 BMS-986020 BMS-986020 (AM152, AP-3152 free acid) is a potent and selective antagonist of lysophosphatidic acid receptor 1 (LPA1). BMS-986020 inhibits bile acid and phospholipid transporters with IC50 of 4.8 μM, 6.2 μM, and 7.5 μM for BSEP, MRP4, and MDR3, respectively. BMS-986020 has the potential for the treatment of idiopathic pulmonary fibrosis (IPF).
S9691 BMS-986158 BMS-986158 is a potent inhibitor of BET with IC50s of 6.6 nM and 5 nM in NCI-H211 small cell lung cancer (SCLC) cells and MDA-MB231 triple negative breast cancer (TNBC) cells, respectively.
S3477 BMS-986187 BMS-986187 is a potent and selective positive allosteric modulator (PAM) of the δ-opioid receptor and a G-protein-biased allosteric agonist.
S3478 BMS-986188 BMS-986188 is a positive allosteric modulator (PAM) of δ-opioid receptors with EC50 of 0.05 μM in a β-arrestin recruitment assay.
S2932 BMS-986260 BMS-986260 is a potent, selective, and orally bioavailable inhibitor of TGFβR1 with IC50 of 1.6 nM.
S9899 BMS-986299

BMS-986299 is a novel NLRP3 agonist that induces IL8 release to activate natural killer (NK) cells.

S9644 BMS-P5 BMS-P5 (EX-A4667) is a specific and orally active inhibitor of peptidylarginine deiminase 4 (PAD4).
S0277 BMS303141 BMS-303141 is a potent, cell-permeable inhibitor of ATP-citrate lyase (ACL) with IC50 of 0.13 μM. BMS-303141 shows inhibition of total lipid syntheses with IC50 of 8 μM in HepG2 cells.
S6622 BMS309403 BMS309403 is a small-molecule FABP4 inhibitor with nM affinity (Kd=4 nM for FABP4) and >100-fold selectivity against FABP5 as well as the heart isoform FABP3.
S0824 BMVC-8C3O BMVC-8C3O is a DNA G-quadruplexe (G4) ligand that induces topological conversion of non-parallel to parallel forms in human telomeric DNA G4s.
S2691 BMY 7378 Dihydrochloride BMY 7378 is a multi-targeted inhibitor of α2C-adrenoceptor and α1D-adrenoceptor with pKi of 6.54 and 8.2, respectively, and acts as a mixed agonist and antagonist for 5-HT1A receptor with pKi of 8.3.
S0873 BNC105 BNC105, a novel compound developed as a Vascular Disrupting Agent (VDA) for treatment of cancer, is a tubulin polymerization inhibitor.
S0552 BNC210 BNC210 (H-Ile-Trp-OH, IW-2143) is a negative allosteric modulator of alpha-7 nicotinic acetylcholine receptor (α7 nAChR).
A5150 BNIP1 Rabbit Recombinant mAb BNIP1 Rabbit Recombinant mAb detects endogenous level of BNIP1.
S1429 BnO-PEG4-OH BnO-PEG4-OH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1682 BnO-PEG5-OH BnO-PEG5-OH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S0678 BnO-PEG6-OH BnO-PEG6-OH is a non-cleavable 6-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S8965 BO-264 BO-264 is a potent and orally active inhibitor of transforming acidic coiled-coil 3 (TACC3) with IC50 of 188 nM and Kd of 1.5 nM. BO-264 specifically blocks the function of FGFR3-TACC3 fusion protein. BO-264 induces SAC-dependent mitotic arrest, apoptosis and DNA damage with antitumor activities.
S6682 Bobcat339 hydrochloride Bobcat339 is a selective cytosine-based TET enzyme inhibitor with IC50 of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 can reduce DNA 5-hydroxymethylcytosine abundance by inhibiting TET enzyme function in living cells and provide support for its utility as a viable pharmacological probe.
S1963 Boc-11-aminoundecanoic acid Boc-11-aminoundecanoic acid is an Alkyl/ether-based PROTAC linker that is applicable to the synthesis of MS432.
S0333 BOC-Dap-NE BOC-Dap-NE is an active compound.
S1694 Boc-GABA-OH Boc-GABA-OH is a PROTAC linker that can be applied to synthesis UNC6852, an EED-targeted PROTAC.
S0579 Boc-Gly-Gly-Phe-Gly-OH Boc-Gly-Gly-Phe-Gly-OH (GGFG) is a self-assembly of N- and C-protected tetrapeptide, a protease cleavable linker used for the antibody-drug conjugates (ADCs).
S1355 Boc-N-Amido-PEG2-C2-azide Boc-N-Amido-PEG2-C2-azide is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1632 Boc-N-Amido-PEG3-azide Boc-N-Amido-PEG3-azide is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S0570 Boc-NH-C6-Br Boc-NH-C6-Br is a cleavable linker applied into the synthesis of antibody-drug conjugates (ADCs).
S1879 Boc-NH-PEG1-CH2COOH Boc-NH-PEG1-CH2COOH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1886 Boc-NH-PEG12-CH2CH2COOH Boc-NH-PEG12-CH2CH2COOH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1279 Boc-NH-PEG2-C2-NH2 Boc-NH-PEG2-C2-NH2 is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1955 Boc-NH-PEG2-CH2COOH Boc-NH-PEG2-CH2COOH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1298 Boc-NH-PEG3 Boc-NH-PEG3 is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1961 Boc-NH-PEG4 Boc-NH-PEG4 is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S0698 Boc-NH-PEG4-CH2CH2COOH Boc-NH-PEG4-CH2CH2COOH is a PEG-based PROTAC linker can be applied into the synthesis of PROTAC. Boc-NH-PEG4-CH2CH2COOH is a cleavable ADC linker used as a linker for antibody-drug conjugates (ADC).
S0575 Boc-NH-PEG4-CH2CH2NH2 Boc-NH-PEG4-CH2CH2NH2 a cleavable 5-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S1942 Boc-NH-PEG6-azide Boc-NH-PEG6-azide is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1824 Boc-NH-PEG7-acid Boc-NH-PEG7-acid is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1821 Boc-NH-PEG7-azide Boc-NH-PEG7-azide is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1936 Boc-NH-PEG8-CH2CH2COOH Boc-NH-PEG8-CH2CH2COOH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S0585 Boc-Val-Cit-OH Boc-Val-Cit-OH is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0335 Boc-Val-Cit-PAB-PNP Boc-Val-Cit-PAB-PNP is a cleavable linker of ADC that is used in the synthesis of antibody-drug conjugates (ADCs).
S3733 Boceprevir Boceprevir (EBP 520, SCH 503034) is an oral, direct acting hepatitis C virus (HCV) protease inhibitor with Ki value of 14 nM for NS3. It is used in combination with other antiviral agents in the treatment of chronic hepatitis C, genotype 1.
S6531 Bohemine Bohemine is a CDK inhibitor with IC50s of 4.6, 83, and 2.7 μM for Cdk2/cyclin E, Cdk2/cyclin A, and Cdk9/cyclin T1, respectively.
S5225 Boldenone Boldenone (Dehydrotestosterone) is an anabolic steroid developed for veterinary use, mostly for treatment of horses.
S3715 Boldenone Undecylenate Boldenone is an agonist of the androgen receptor (AR). Boldenone Undecylenate is a derivative of testosterone, which has strong anabolic effect and only moderately androgenic.
S9050 Boldine Boldine, isolated from Peumus boldus, has alpha-adrenergic antagonist activities in vascular tissue with anti-oxidant, hepatoprotective, cytoprotective, antipyretic and anti-inflammatory effects.
S3605 Borneol Borneol is a bicyclic monoterpenoid compound extracted from medicinal plants such as Blumea balsamifera, and Dryobalanops aromatica. It is a TRPM8 agonist that increases ocular surface wetness.
S3893 Bornyl acetate Bornyl acetate (Isobornyl, Bornyl acetic ether, 2-Camphanol), the main volatile constituent in numerous conifer oils and some Chinese traditional herbs, exhibits anti-inflammatory property and it is used as an analgesic.
S1013 Bortezomib (PS-341) Bortezomib (PS-341, Velcade, LDP-341, MLM341, NSC 681239) is a potent 20S proteasome inhibitor with Ki of 0.6 nM. It exhibits favorable selectivity towards tumor cells over normal cells. Bortezomib (PS-341) inhibits NF-κB and induces ERK phosphorylation to suppress cathepsin B and inhibit the catalytic process of autophagy in ovarian cancer and other solid tumors.
S8839 Borussertib Borussertib is a covalent-allosteric inhibitor of protein kinase Akt with an IC50 of 0.8 nM and a Ki of 2.2 nM for WT Akt.
S8911 BOS172722 BOS172722 is a monopolar spindle 1 (MPS1) checkpoint inhibitor with IC50 of 11 nM, Ki of 0.11 nM.
S3051 Bosentan Hydrate Bosentan (Ro 47-0203) is an endothelin (ET) receptor antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively.
S1014 Bosutinib (SKI-606) Bosutinib (SKI-606) is a novel, dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM in cell-free assays, respectively. Bosutinib also effectively decreases the activity of PI3K/AKT/mTOR, MAPK/ERK and JAK/STAT3 signaling pathways by blocking the phosphorylation levels of p-ERK, p-S6, and p-STAT3. Bosutinib promotes autophagy.
S6762 Bozitinib (PLB-1001) Bozitinib (PLB-1001, CBT-101, APL-101, CBI-3103) is a highly selective ATP-competitive c-Met inhibitor with blood-brain barrier permeability. Bozitinib (PLB-1001) selectively inhibits MET-altered tumor cells in preclinical models.
S0414 BP 897 BP 897 is a potent and selective agonist of dopamine D3 receptor and a weak antagonist of dopamine D2 receptor with Ki of 0.92 nM and 61 nM for D3 and D2 receptors, respectively. BP 897 shows low affinities at D1 and D4 receptors with Ki of 3 µM and 0.3 µM, respectively.
E0085 BPAM344

BPAM344 is a novel potent positive allosteric modulator (PAM) of the three KAR subunits GluK1b, GluK2a, and GluK3a.

S0212 BPR1J-097 BPR1J-097 is a novel potent inhibitor of FLT3 with IC50 of 11 nM.
S0840 BPR1K871 BPR1K871 (DBPR114) is a potent and selective dual inhibitor of FLT3 and AURKA with IC50 of 19 nM and 22 nM, respectively. BPR1K871 (DBPR114) acts as a preclinical development candidate for anti-cancer therapy.
S7753 BPTES BPTES is a potent and selective Glutaminase GLS1 (KGA) inhibitor with IC50 of 0.16 μM. It has no effect on glutamate dehydrogenase activity and causes only a very slight inhibition of γ-glutamyl transpeptidase activity.
S0296 BPTU BPTU (BMS-646786) is a novel allosteric antagonist of P2Y1.
S8651 bpV (HOpic) bpV (HOpic) (Bisperoxovanadium (HOpic)) is a potent inhibitor of PTEN with an IC50 of 14 nM. The IC50s for PTP-β and PTP-1B are about 350- and 1800-fold higher than the IC50 for PTEN, respectively.
S7883 BQ-123 BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2.
S5931 BQCA BQCA (benzylquinolone carboxylic acid) is a highly selective positive allosteric modulator of the M1 muscarinic acetylcholine receptor (mAChR).
S6571 BQR695 BQR695 (NVP-BQR695) is a quinoxaline that displays sub-micromolar potency against human PI4KIIIβ (IC50~90 nM).
S2936 BQT BQT is a bound ligand of 6epv which is the ATAD2 bromodomain in complex with compound 5.
S7607 BQU57 BQU57, a derivative of RBC8, is a selective GTPase Ral inhibitor relative to the GTPases Ras and RhoA.
S1659 Br-C10-methyl ester Br-C10-methyl ester is a PROTAC linker that refers to the alkyl/ether composition. Br-C10-methyl ester is applicable to the synthesis of a series of PROTACs.
S1552 Br-PEG3-C2-Boc Br-PEG3-C2-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1684 Br-PEG3-OH Br-PEG3-OH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1852 Br-PEG4-CH2-Boc Br-PEG4-CH2-Boc is a PEG- and Alkyl/ether-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1449 Br-PEG4-OH Br-PEG4-OH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S3547 Bractoppin Bractoppin is a potent and selective inhibitor that specific selectively blocks phosphopeptide recognition by the BRCA1 tBRCT domain with binding IC50 of 74 nM.
E0037 Bradykinin

Bradykinin is a potent vasodilator peptide that exerts its vasodilatory action through stimulation of specific endothelial B2 receptors, thereby causing the release of prostacyclin, NO, and EDHF.

S6642 Branaplam (LMI070) Branaplam (LMI070) is a highly selective, small-molecule splicing modulators of survival motor neuron‑2 (SMN2) with an EC50 of 0.02 μM.
S8832 Branebrutinib (BMS-986195) Branebrutinib (BMS-986195) is a potent inhibitor of BTK with IC50 values of 0.1 nM, 0.9 nM, 1.5 nM, 5 nM for BTK, TEC, BMX, TXK, respectively.
S6781 Brassinazole Brassinazole (BRZ) is a potent inhibitor of brassinosteroid (BR) biosynthesis with IC50 of ~ 1 μM, that has been developed to probe the myriad functions of brassinosteroids. Brassinosteroids are a class of phytohormones with essential roles in plant growth and development, including the promotion of stem elongation and cell division.
S9428 Brazilin Brazilin (Natural Red 24) is a red pigment obtained from the wood of the brazilwood family. It is used to dye fabric and has diverse biological activities, including neuroprotective, anti-inflammatory, antibacterial, and antioxidant properties.
E0391 BRD-6929

BRD-6929 is a potent, selective brain-penetrant inhibitor of class I histone deacetylase HDAC1 and HDAC2 inhibitor with IC50 of 1 nM and 8 nM, respectively. BRD-6929 shows high-affinity to HDAC1 and HDAC2 with Ki of 0.2 and 1.5 nM, respectively. BRD-6929 can be used for mood-related behavioral model research.

S8844 BRD0539 BRD0539 is a potent inhibitor of Streptococcus pyogenes Cas9 (SpCas9) with IC50 of 22 μM in an in vitro DNA cleavage assay.
E1007 BRD0639

BRD0639 is a first-in-class PBM-competitive small molecule inhibitor that disrupts the PRMT5-RIOK1 complex with IC50s of 7.5 μM and 16 μM in permeabilized and living cells, respectively.

S9638 BRD0705 BRD0705 is a potent, paralog selective and orally active inhibitor of GSK3α (Glycogen synthase kinase 3α) with IC50 of 66 nM and Kd of 4.8 μM. BRD0705 also inhibits GSK3β with IC50 of 515 nM. BRD0705 can be used for acute myeloid leukemia (AML).
S8962 BRD3308 BRD3308 is a potant and highly selective inhibitor of HDAC3 with IC50 of 54 nM, 1.26 μM and 1.34 μM for HDAC3, HDAC1 and HDAC2, respectively. BRD3308 activates HIV-1 transcription. BRD3308 suppresses pancreatic β-cell apoptosis induced by inflammatory cytokines (glucolipotoxic stress) and increases functional insulin release.
A5058 Brd4 Rabbit Recombinant mAb Brd4 Rabbit Recombinant mAb detects endogenous levels of total Brd4.
S0771 BRD6989 BRD6989 is a selective inhibitor of CDK8 and CDK19. BRD6989 upregulates IL-10. BRD6989 is an analog of the natural product cortistatin A (dCA).
S2943 BRD9539 BRD9539 is an inhibitor of histone methyltransferase G9a with IC50 of 6.3 μM. BRD9539 also inhibits PRC2 activity.
S7046 Brefeldin A Brefeldin A is a lactone antibiotic and ATPase inhibitor for protein transport with IC50 of 0.2 μM in HCT 116 cells, induces cancer cell differentiation and apoptosis. It could also improve the HDR(homology-directed repair) efficiency and be an enhancer of CRISPR-mediated HDR. Brefeldin A is also an inhibitor of autophagy and mitophagy.
S8804 Brepocitinib (PF-06700841) Brepocitinib (PF-06700841, PF-841) is a potent inhibitor of Tyk2 and Jak1 with IC50s of 23 nM, 17 nM, 77 nM for Tyk2, Jak1 and Jak2 respectively. It has appropriate in-family selectivity against JAK2 and JAK3.
S6626 Brequinar (DUP785) Brequinar (DUP785, NSC 368390) is an inhibitor of dihydroorotate dehydrogenase (DHODH) with an IC50 of ∼20 nM in vitro.
S3565 Brequinar Sodium Brequinar Sodium (Bipenquinate, BRQ, DUP-785, NSC 368390) is a potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of ~20 nM and triggers differentiation in the ER-HoxA9, U937, and THP1 cells with ED50 of ~1 μM.
S6751 Brevianamide F Brevianamide F, belonging to a class of naturally occurring 2,5-diketopiperazines, is the simplest member and the biosynthetic precursor of a large family of biologically active prenylated tryptophan-proline 2,5-diketopiperazines that are produced by the fungi A.fumigates and Aspergillus sp..
S6919 Brevilin A Brevilin A (6-O-Angeloylplenolina), a sesquiterpene lactone isolated from Centipeda minima, is a selective inhibitor of STAT3 and attenuates the JAKs activity by blocking the JAKs tyrosine kinase domain JH1. Brevilin A induces apoptosis and autophagy of colon adenocarcinoma cell CT26 via mitochondrial pathway and PI3K/AKT/mTOR inactivation.
S4639 Brexpiprazole Brexpiprazole (OPC-34712) is a novel D2 dopamine and serotonin 1A partial agonist, called serotonin-dopamine activity modulator (SDAM), and a potent antagonist of serotonin 2A receptors, noradrenergic alpha 1B and 2C receptors with Ki values of 0.3, 0.12, 0.47, 0.17 and 0.59 nM for D2L, 5-HT1A, 5-HT2A, α1B receptors and α2C receptors respectivey.
A5361 BRG1 Rabbit Recombinant mAb BRG1 Rabbit Recombinant mAb detects endogenous level of total BRG1.
S6533 Briciclib Briciclib (ON-014185) is a water soluble derivative of ON-013100, a small molecule that binds to and inhibits eukaryotic translation initiation factor 4E (eIF4E).
S8229 Brigatinib (AP26113) Brigatinib (AP26113) is a potent and selective ALK (IC50, 0.6 nM) and ROS1 (IC50, 0.9 nM) inhibitor. It also inhibits IGF-1R, FLT3, and mutant variants of FLT3 (D835Y) and EGFR with lower potentcy.
S7855 Brilanestrant (GDC-0810) Brilanestrant (GDC-0810, ARN-810) is a potent ER-α binder (ER-α, IC50 = 6.1 nM; ER-β, IC50 = 8.8 nM), a full transcriptional antagonist with no agonism and displays good potency and efficacy in ER-α degradation (EC50 = 0.7 nM) and MCF-7 breast cancer cell viability (IC50 = 2.5 nM) assays with good selectivity over other nuclear hormone receptors.
S3217 Brilliant Blue G Brilliant Blue G (BBG) is a potent non-competitive antagonist of P2X7 receptor with IC50 of 10.1 nM and 265 nM for rat P2X7 and human P2X7, respectively. Brilliant Blue G is a dye which is commonly used in laboratories to stain or quantify proteins.
S9508 Brimonidine Brimonidine (Bromoxidine, UK 1430) is an alpha adrenergic receptor agonist (primarily alpha-2) and is used for the treatment of open-angle glaucoma or ocular hypertension to lower intraocular pressure.
S4266 Brimonidine Tartrate Brimonidine Tartrate is a highly selective α-adrenergic receptor agonist with EC50 of 0.45 nM for the α2A adrenoreceptor, and used to treat open-angle glaucoma or ocular hypertension.
S3178 Brinzolamide Brinzolamide (AL-4862) is a potent carbonic anhydrase II inhibitor with IC50 of 3.19 nM.
S0166 BRITE338733 BRITE-338733 is a potent RecA (a DNA-dependent ATPase) inhibitor with IC50 of 4.7 µM.
S1084 Brivanib (BMS-540215) Brivanib is an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM, moderate potency against VEGFR-1 and FGFR-1, but >240-fold against PDGFR-β. Phase 3.
S1138 Brivanib Alaninate (BMS-582664) Brivanib alaninate (BMS-582664) is the prodrug of BMS-540215, an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM.
S5009 Brivudine Brivudine (BVDU) is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. It is incorporated into the viral DNA and blocks the action of DNA polymerases, thus inhibiting viral replication.
S0723 BRL 15572 BRL 15572 is selective antagonist of 5-HT1D with around 60× selectivity over other related receptors. BRL 15572 is a useful tool for the differentiation between human 5-HT1B and 5-HT1D receptors in functional studies.
S2677 BRL-15572 Dihydrochloride BRL-15572 is a 5-HT1D receptor antagonist with pKi of 7.9, also shows a considerable affinity at 5-HT1A and 5-HT2B receptors, exhibiting 60-fold selectivity over 5-HT1B receptor.
E0111 BRM/BRG1 ATP Inhibitor-1 BRM/BRG1 ATP Inhibitor-1 (Compound 14) is an orally active inhibitors of Brahma Homolog (BRM)/SMARCA2 (BRG1) with IC50s below 0.005 µM.
A2032 Brodalumab (anti-IL17RA) Brodalumab (anti-IL17RA) (KHK4827, AMG 827) is a recombinant, fully human monoclonal antibody (IgG2) which binds with high affinity to the interleukin (IL) 17 receptor A (IL17R).
S4248 Bromfenac Sodium Bromfenac Sodium (AHR 10282R) is a nonsteroidal anti-inflammatory drug (NSAID), which has anti-inflammatory activity and may block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2.
S5786 Bromfenac sodium hydrate Bromfenac sodium hydrate (Bromsite, Bromday, Prolensa, Xibrom), a brominated nonsteroidal anti-inflammatory drugs (NSAID) with strong in vitro anti-inflammatory potency, is a potent and orally active inhibitor of COX with IC50 of 5.56 nM and 7.45 nM for COX-1 and COX-2, respectively.
S5943 Bromhexine Bromhexine is an expectorant/mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus
S2060 Bromhexine HCl Bromhexine HCl is a medication prescribed for coughs which works by dissolving hard phlegm.
S5305 Bromisoval Bromisoval (Bromovalerylurea, Isobromyl, Bromaral, BRN 1773255) is a hypnotic and sedative of the bromoureide group with anti-inflammatory effects.
S1906 Bromo-PEG1-C2-Boc Bromo-PEG1-C2-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1868 Bromo-PEG1-CH2-Boc Bromo-PEG1-CH2-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1686 Bromo-PEG2-alcohol Bromo-PEG2-alcohol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1918 Bromo-PEG2-C2-Boc Bromo-PEG2-C2-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1850 Bromo-PEG2-CH2-Boc Bromo-PEG2-CH2-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1817 Bromo-PEG3-CH2-Boc Bromo-PEG3-CH2-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1687 Bromo-PEG4-bromide Bromo-PEG4-bromide is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S7918 Bromodeoxyuridine (BrdU) Bromodeoxyuridine (BrdU, 5-Bromo-2'-deoxyuridine, BUdR) is a nucleoside analog that competes with thymidine for incorporation into DNA, and used in the detection of proliferating cells.
S5426 Bromopyruvic acid Bromopyruvic acid (3-Bromopyruvic acid, 3-Bromopyruvate, Bromopyruvic acid, Hexokinase II Inhibitor II, 3-BP) is a hexokinase II inhibitor with Ki of 2.4 mM for glycolysis/hexokinase inhibition. It is inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs.
S2585 Brompheniramine hydrogen maleate Brompheniramine hydrogen maleate is a histamine H1 receptors antagonist.
S4553 Bronopol Bronopol (2-bromo-2-nitropropane-1,3-diol) is antibacterial agent, used as preservative in cosmetic industry.
S0146 Broxaldine Broxaldine (Brobenzoxaldine, AL307) is an antiprotozoal drug and can be used in leprosy.
S4195 Broxyquinoline Broxyquinoline is an antiprotozoal agent and able to release oxygen free radicals from the water in mucous membranes.
S0816 Brr2 Inhibitor C9 Brr2 inhibitor C9 (Brr2 Inhibitor 9) is an allosteric inhibitor of the spliceosomal RNA helicase Brr2. Brr2 is implicated in autosomal-dominant retinitis pigmentosa a group of progressive retinal degenerative disorders.
S4390 Brucine Brucine, an alkaloid closely related to strychnine, is most commonly found in the Strychnos nux-vomica tree.
S6172 Brucine sulfate heptahydrate Brucine is an alkaloid that acts as an antagonist at glycine receptors and paralyzes inhibitory neurons.
S7956 Brusatol Brusatol (NSC 172924), isolated from the fruit of B. javanica, is a NRF2 inhibitor.
S8815 BSJ-03-123 BSJ-03-123 is a phthalimide-based degrader of cyclin-dependent kinase 6 (CDK6). (PROTAC)
S9859 BSJ-4-116 BSJ-4-116 is a specific degrader of cyclin-dependent kinase 12 (CDK12). BSJ-4-116 exhibits potent antiproliferative effects.
S9728 BSO (L-Buthionine-(S,R)-sulfoximine)

BSO (L-Buthionine-(S,R)-sulfoximine, L-Buthionine sulfoximine) is a cell-permeable, potent, fast acting and irreversible inhibitor of g-glutamylcysteine synthetase (γ-glutamylcysteine synthetase, γ-GCS) and depletes cellular glutathione levels. The IC50 of BSO on melanoma, breast and ovarian tumor specimens are 1.9 μM, 8.6 μM, and 29 μM, respectively.

S6796 BTB-1 BTB-1 is a novel, selective and reversible inhibitor of the mitotic motor protein Kif18A with IC50 of 1.69 μM.
S0006 BTdCPU BTdCPU is a potent heme-regulated eIF2α kinase (HRI) activator and promotes eIF2α phosphorylation. BTdCPU induces apoptosis in resistant cell.
S8542 Btk inhibitor 2 Btk inhibitor 2 is a BTK inhibitor.
S0307 BTR-1 BTR-1 is an active anti-cancer agent which can cause S phase arrest and affect DNA replication in leukemic cells. BTR-1 activates apoptosis and induces cell death.
E0328 BTRX-335140

BTRX-335140 (CYM-53093) is a potent and selective, orally active κ opioid receptor (KOR) antagonist, with IC50 values of 0.8 nM, 110 nM, and 6500 nM for κOR, μOR and δOR, respectively.

S8650 BTSA1 BTSA1 is a pharmacologically optimized BAX activator that binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis. It effectively promotes apoptosis in leukemia cell lines and patient samples while sparing healthy cells.
S9871 BTYNB BTYNB (BTYNB IMP1 Inhibitor, MDK6620) is a potent and selective inhibitor of IMP1 binding to c-Myc mRNA. BTYNB downregulates β-TrCP1 mRNA and reduces activation of nuclear transcriptional factors-kappa B (NF-κB). BTYNB disrupts this enhancer function by impairing IGF2 mRNA-binding protein 1 (IGF2BP1)-RNA association.
S1097 BTZ043 Racemate BTZ043 racemate is a decaprenylphosphoryl-β-D-ribose 2'-epimerase (DprE1) inhibitor acting as a new antimycobacterial agent that kill Mycobacterium tuberculosis.
S0539 BTZO-1 BTZO-1 binds to macrophage migration inhibitory factor (MIF) with Kd of 68.6 nM. BTZO-1 activats antioxidant response element (ARE)-mediated gene expression and suppresses oxidative stress-induced cardiomyocyte apoptosis in vitro.
S4554 Bucetin Bucetin is an analgesic and antipyretice agent with a risk of carcinogenesis.
S4140 Buclizine HCl Buclizine HCl (UCB-4445) is an antihistamine and anticholinergic of the piperazine derivative family.
S9074 Buddlejasaponin IVb Buddlejasaponin IVb (Saikosaponin 1b), a major component of Pleurospermum kamtschaticum, exerts anti-inflammatory and cytotoxic effects against cancer cells.
S1286 Budesonide Budesonide is a glucocorticoid steroid for the treatment of asthma, non-infectious rhinitis.
S7821 Bufalin Bufalin (BF) is a potent inhibitor of steroid receptor coactivator SRC-3, SRC-1 and Na+/K+-ATPase. Bufalin binds to the subunit α1, α2 and α3 of Na+/K+-ATPase with Kd of 42.5 nM, 45 nM and 40 nM, respectively. Bufalin is a major digoxin-like immunoreactive component isolated from the Chinese medicine Chan Su with anti-cancer activity.
S3023 Bufexamac Bufexamac is a COX inhibitor for IFN-α release with EC50 of 8.9 μM.
S2607 Buflomedil HCl Buflomedil HCl is a vasodilator used to treat claudication or the symptoms of peripheral arterial disease; A nonselective alpha adrenergic receptor inhibitor.
S0910 Bufotalin Bufotalin, a novel anti-osteoblastoma agent, is a cardiotoxic bufanolide steroid and a cardiac glycoside analogue. Bufotalin is secreted by a number of toad species.
P1105 Bulevirtide (Myrcludex B) Bulevirtide (Myrcludex B) is a sodium-taurocholate co-transporting polypeptide (NTCP) receptor inhibitor with IC50 of ∼80 pM and inactivates NTCP function at concentrations far below those required to block bile salt transport.
S0945 Bullatine B Bullatine B (Neoline) alleviates oxaliplatin-induced peripheral neuropathy in mice and can be used as a marker compound to determine the quality of the PA products for the treatment of neuropathic pain. Bullatine B is the active ingredient of processed aconite root (PA).
S3907 Bulleyaconi cine A Bulleyaconi cine A (Bulleyaconitine A, BLA) is an active ingredient of Aconitum bulleyanum plants and classified as an "aconitine-like" alkaloid. It is a potent use-dependent blocker for both Nav1.7 and Nav1.8 Na+ currents.
S1287 Bumetanide Bumetanide (Bumex) is a loop diuretic of the sulfamyl category to treat heart failure. Bumetanide is a selective Na+-K+-Cl- cotransporter 1 (NKCC1) inhibitor, weakly inhibits NKCC2, with IC50s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respectively.
S2247 Buparlisib (BKM120) Buparlisib (BKM120, NVP-BKM120) is a selective PI3K inhibitor of p110α/β/δ/γ with IC50 of 52 nM/166 nM/116 nM/262 nM in cell-free assays, respectively. Reduced potency against VPS34, mTOR, DNAPK, with little activity to PI4Kβ. Buparlisib induces apoptosis. Phase 2.
S4971 Buparvaquone Buparvaquone (Butalex) is a second-generation hydroxynaphthoquinone related to parvaquone, with novel features that make it a promising compound for the therapy and prophylaxis of all forms of theileriosis.
S2454 Bupivacaine HCl Bupivacaine HCl binds to the intracellular portion of voltage-gated sodium channels and blocks sodium influx into nerve cells, used for treating cardiac arrhythmias.
E0089 Bupranolol

Bupranolol is an adrenergic-beta-2 antagonist. Bupranolol might be useful for prevention or treatment of thrombosis.

S4256 Buspirone HCl Buspirone is a serotonergic (5HT(1A) receptor agonist) anxiolytic drug with some D(2) dopaminergic effect, used for anxiety disorders.
S1692 Busulfan (NSC-750) Busulfan (NSC-750) is a cell cycle non-specific alkylating antineoplastic agent. Busulfan induces apoptosis.
S4583 Butamben Butamben (Butyl 4-aminobenzoate) is a long-duration local anesthetic used for the treatment of chronic pain.
S1765 Butane-1,4-diyldiphosphonic acid Butane-1,4-diyldiphosphonic acid is an alkyl chain-based PROTAC linker that is applicable to the synthesis of PROTACs.
S5944 Butenafine Butenafine is a synthetic benzylamine antifungal agent.
S3154 Butenafine HCl Butenafine HCl (KP-363) is a synthetic benzylamine antifungal, works by inhibiting the synthesis of sterols by inhibiting squalene epoxidase.
S5359 Butoconazole Butoconazole is an imidazole antifungal used in gynecology.
S1833 Butoconazole nitrate Butoconazole nitrate (RS-35887) is an anti-fungal agent that inhibits PHA-stimulated release of cytokines-- IL-2, TNFα, IFN and GM-CSF from human peripheral blood lymphocytes (IC50 of 7.2 μg/mL, 14.4 μg/mL, 7.36 μg/mL and 7.6 μg/mL, respectively).
S5822 Butyl benzyl phthalate Butyl benzyl phthalate (BBP, 1,2-benzenedicarboxylic acid, butyl phenylmethyl ester) is a member of the group of chemicals known as phthalates. It is a toxicant and may be used as a plasticiser.
S0553 Butyl isobutyl phthalate  Butyl isobutyl phthalate (BIP), isolated from the rhizoid of Laminaria japonica, is a non-competitive inhibitor of α-glucosidase with IC50 of 38 μM. Butyl isobutyl phthalate displays a significant hypoglycemic effect and has the potential for diabetes treatment.
S6202 Butylated hydroxytoluene Butylated hydroxytoluene (dibutylhydroxytoluene, Dibutylated hydroxytoluene, AO-29, BHT) is a lipophilic organic compound that is useful for its antioxidant properties.
S4584 Butylparaben Butylparaben (Butyl parahydroxybenzoate, Butyl 4-hydroxybenzoate) is a chemical compound commonly used as an antifungal preservative in cosmetic products.
S2378 Butylscopolamine Bromide Butylscopolamine Bromide (Scopolamine Butylbromide), is a peripherally acting antimuscarinic, anticholinergic agent used as an abdominal-specific antispasmodic.
S0209 BVT 2733 BVT 2733, a new small molecule, is a non-steroidal, isoform-selective inhibitor of 11beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1).
S0229 BVT-14225 BVT-14225 is a selective inhibitor of 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) with IC50 of 52 nM.
S9829 BVT-948 BVT 948 is a irreversible, noncompetitive and cell-permeable protein tyrosine phosphatase(PTP) inhibitor with IC50s of 0.9 μM, 1.7 μM, 0.09 μM, 1.5 μM and 0.7 μM for PTP1B, TCPTP, SHP-2, LAR and YopH respectively.
S6576 BW-A78U BW-A78U, an adenine derivative PDE inhibitor, has anticonvulsant activity.
S1274 BX-795 BX-795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1. BX-795 modulates autophagy via inhibiting ULK1. BX-795 also is a potent TBK1 inhibitor that blocks both TBK1 and IKKε with IC 50 values of 6 nM and 41 nM, respectively.
S1275 BX-912 BX912 is a potent and specific PDK1 inhibitor with IC50 of 12 nM, 9- and 105- fold greater selectivity for PDK1 than PKA and PKC in cell-free assays, respectively. In comparison to GSK3β, selectivity for PDK1 is 600-fold.
S0758 BX430 BX430 is a potent and selective noncompetitive allosteric antagonist of human P2X4 receptor channels with IC50 of 0.54 μM. BX430 is a potent antagonist of zebrafish P2X4 but has no effect on rat and mouse P2X4 orthologs. BX430 is used for chronic pain and cardiovascular disease.
S7604 BX471

BX471 (ZK811752, BAY 865047, SH T 04268H) is a potent nonpeptide CC chemokine receptor-1 (CCR1) antagonist with Ki values of 1 nM and 5.5 nM in both MIP-1α and MCP-3 binding to CCR1-transfected HEK293 cells, respectively.

S6504 BX517 BX517 is a potent and selective inhibitor of PDK1 that binds to the ATP binding pocket of the protein (IC50 = 6 nM).
S0519 BYK204165 BYK204165 is a potent and selective inhibitor of the poly(ADP-ribose) polymerase (PARP). BYK204165 inhibits cell-free recombinant human PARP-1 (hPARP-1) with pIC50 of 7.35 and pKi of 7.05 and murine PARP-2 (mPARP-2) with pIC50 of 5.38, respectively.