Home Microbiology Bacterial chemical Azelaic acid

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Azelaic acid Bacterial chemical

Cat.No.S4550

Azelaic acid (Nonanedioic acid, Finacea, Azelex, Anchoic acid) is an organic compound produced by the ozonolysis of oleic acid and possesses antibacterial, keratolytic, comedolytic, and anti-oxidant activity.
Azelaic acid Bacterial chemical Chemical Structure

Chemical Structure

Molecular Weight: 188.22

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Quality Control

Purity: >97%
97

Solubility

In vitro
Batch:

DMSO : 37 mg/mL (196.57 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 37 mg/mL

Ethanol : 37 mg/mL

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In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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%
% Tween 80
% ddH2O
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 188.22 Formula

C9H16O4

 Storage (From the date of receipt)
CAS No. 123-99-9 Download SDF Storage of Stock Solutions

Synonyms Nonanedioic acid, Finacea, Azelex, Anchoic acid Smiles C(CCCC(=O)O)CCCC(=O)O

Mechanism of Action

In vitro
AZ(Azelaic acid) combined with taurine (Tau) show more inhibitory effects in melanocytes than the treatment of this compound alone. This combination inhibits the melanin production and tyrosinase activity of B16F10 melanoma cells without significant cytotoxicity. Also inhibitory effects after treatment with these combined chemical are stronger than this acid alone on melanogenesis.
In vivo
Azelaic acid exhibits an anti-atherogenic effect. Its athero-protective effect is not related to changes in plasma lipid content. This compound supplementation decreases the level of CD68 macrophage marker by 34% (p<0.05).
References

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