Azelaic acid

For research use only.

Catalog No.S4550 Synonyms: Nonanedioic acid, Finacea, Azelex, Anchoic acid

Azelaic acid Chemical Structure

CAS No. 123-99-9

Azelaic acid (Nonanedioic acid, Finacea, Azelex, Anchoic acid) is an organic compound produced by the ozonolysis of oleic acid and possesses antibacterial, keratolytic, comedolytic, and anti-oxidant activity.

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Biological Activity

Description Azelaic acid (Nonanedioic acid, Finacea, Azelex, Anchoic acid) is an organic compound produced by the ozonolysis of oleic acid and possesses antibacterial, keratolytic, comedolytic, and anti-oxidant activity.
In vitro

AZ(Azelaic acid) combined with taurine (Tau) show more inhibitory effects in melanocytes than the treatment of AZ alone. AZ combined with Tau inhibits the melanin production and tyrosinase activity of B16F10 melanoma cells without significant cytotoxicity. Also inhibitory effects after treatment with these combined chemical are stronger than AZ alone on melanogenesis[2].

In vivo Azelaic acid exhibits an anti-atherogenic effect. Its athero-protective effect is not related to changes in plasma lipid content. Azelaic acid supplementation decreases the level of CD68 macrophage marker by 34% (p<0.05)[1].

Protocol

Cell Research:

[2]

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  • Cell lines: The mouse melanoma cell line B16F10
  • Concentrations: 20 mM
  • Incubation Time: 24 h
  • Method:

    B16F10 melanoma cells are seeded at a density of 2.5×105 cells/60 mm culture dish. The cells are treated with Azelaic acid combined with Tau for 24 hr. The cells pellets are dissolved in 1 N NaOH at 60°C for 1 hr. The relative melanin content is determined by measuring the absorbance at 475 nm in ELISA reader.


    (Only for Reference)
Animal Research:

[1]

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  • Animal Models: Low density lipoprotein receptor knockout (LDLr−/−) mice
  • Dosages: 0.50%
  • Administration: oral administration
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 37 mg/mL (196.57 mM)
Water 37 mg/mL (196.57 mM)
Ethanol ''37 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 188.22
Formula

C9H16O4

CAS No. 123-99-9
Storage powder
in solvent
Synonyms Nonanedioic acid, Finacea, Azelex, Anchoic acid
Smiles C(CCCC(=O)O)CCCC(=O)O

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID