Azelaic acid

Catalog No.S4550 Synonyms: Nonanedioic acid, Finacea, Azelex, Anchoic acid

For research use only.

Azelaic acid (Nonanedioic acid, Finacea, Azelex, Anchoic acid) is an organic compound produced by the ozonolysis of oleic acid and possesses antibacterial, keratolytic, comedolytic, and anti-oxidant activity.

Azelaic acid Chemical Structure

CAS No. 123-99-9

Purity & Quality Control

Choose Selective Bacterial Inhibitors

Biological Activity

Description Azelaic acid (Nonanedioic acid, Finacea, Azelex, Anchoic acid) is an organic compound produced by the ozonolysis of oleic acid and possesses antibacterial, keratolytic, comedolytic, and anti-oxidant activity.
In vitro

AZ(Azelaic acid) combined with taurine (Tau) show more inhibitory effects in melanocytes than the treatment of AZ alone. AZ combined with Tau inhibits the melanin production and tyrosinase activity of B16F10 melanoma cells without significant cytotoxicity. Also inhibitory effects after treatment with these combined chemical are stronger than AZ alone on melanogenesis[2].

In vivo Azelaic acid exhibits an anti-atherogenic effect. Its athero-protective effect is not related to changes in plasma lipid content. Azelaic acid supplementation decreases the level of CD68 macrophage marker by 34% (p<0.05)[1].

Protocol (from reference)

Cell Research:

[2]

  • Cell lines: The mouse melanoma cell line B16F10
  • Concentrations: 20 mM
  • Incubation Time: 24 h
  • Method:

    B16F10 melanoma cells are seeded at a density of 2.5×105 cells/60 mm culture dish. The cells are treated with Azelaic acid combined with Tau for 24 hr. The cells pellets are dissolved in 1 N NaOH at 60°C for 1 hr. The relative melanin content is determined by measuring the absorbance at 475 nm in ELISA reader.

Animal Research:

[1]

  • Animal Models: Low density lipoprotein receptor knockout (LDLr−/−) mice
  • Dosages: 0.50%
  • Administration: oral administration

Solubility (25°C)

In vitro

DMSO 37 mg/mL
(196.57 mM)
Water 37 mg/mL
(196.57 mM)
Ethanol ''37 mg/mL

Chemical Information

Molecular Weight 188.22
Formula

C9H16O4

CAS No. 123-99-9
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C(CCCC(=O)O)CCCC(=O)O

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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