Avibactam sodium

Catalog No.S3732 Synonyms: AVE-1330A, NXL104

For research use only.

Avibactam (AVE-1330A, NXL104) is a covalent, reversible, non-β-lactam β-lactamase inhibitor with IC50 values of 8, 80, and 38 nM for TEM-1, P99, and KPC-2 β-lactamases, respectively.

Avibactam sodium Chemical Structure

CAS No. 1192491-61-4

Selleck's Avibactam sodium has been cited by 2 Publications

Purity & Quality Control

Choose Selective β-lactamase Inhibitors

Biological Activity

Description Avibactam (AVE-1330A, NXL104) is a covalent, reversible, non-β-lactam β-lactamase inhibitor with IC50 values of 8, 80, and 38 nM for TEM-1, P99, and KPC-2 β-lactamases, respectively.
Targets
SHV-4 [1]
(Cell-free assay)
TEM-1 [1]
(Cell-free assay)
KPC-2 [1]
(Cell-free assay)
P99 [1]
(Cell-free assay)
1.5 nM 8 nM 38 nM 80 nM
In vitro

Avibactam (formerly NXL104, AVE1330A) is a synthetic non-β-lactam, β-lactamase inhibitor inhibits the activities of Ambler class A and C β-lactamases and some Ambler class D enzymes[1]. Avibactam has an unusual mechanism of action: it is a covalent inhibitor that acts via ring opening, but in contrast to other currently used β-lactamase inhibitors, this reaction is reversible[2].

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 287.23
Formula

C7H10N3O6 .Na

CAS No. 1192491-61-4
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1CC(N2CC1N(C2=O)OS(=O)(=O)[O-])C(=O)N.[Na+]

In vivo Formulation Calculator (Clear solution)

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01448395 Completed Drug: [14C]NXL104 Healthy Pfizer October 2011 Phase 1
NCT01291602 Completed Drug: NXL104|Drug: CAZ104|Drug: Placebo Healthy Male and Female Japanese Volunteers Pfizer February 2011 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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