Atorvastatin Calcium

Licensed by Pfizer Catalog No.S2077

Atorvastatin Calcium  Chemical Structure

Molecular Weight(MW): 1155.34

Atorvastatin Calcium is an inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol.

Size Price Stock Quantity  
In DMSO USD 140 In stock
USD 110 In stock
USD 770 In stock
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Cited by 1 Publication

1 Customer Review

  • Micrographs of hematoxylin and eosin-stained liver sections from untreated and atorvastatin-treated TO mouse. Results of representative experiment of liver specimens incubated in vitro at 37癈 with and without 1.0 礛 atorvastatin for 6 hr is shown. A liver specimen at 0 hr is also shown. Liver structure and cytology are preserved in treated and untreated specimens. Inflammation and cholestasis are absent. (Hematoxylin and eosin, 10?and 40?.

    BMC Pharmacol Toxicol 2013 14, 15. Atorvastatin Calcium purchased from Selleck.

Purity & Quality Control

Choose Selective HMG-CoA Reductase Inhibitors

Biological Activity

Description Atorvastatin Calcium is an inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol.
Targets
HMG-CoA reductase [1]
(Cell-free assay)
In vitro

Atorvastatin inhibits pre-proET-1 mRNA expression in a concentration- and time-dependent fashion (60-70% maximum inhibition) and reduces immunoreactive ET-1 levels (25-50%), this inhibitory effect is maintained in the presence of oxidized LDL (1-50 mg/mL). [1] Atorvastatin significantly reduces angiotensin II-induced and epidermal growth factor-induced ROS production in VSMCs. Atorvastatin downregulates mRNA expression of the NAD(P)H oxidase subunit nox1 in VSMCs, whereas p22phox mRNA expression is not significantly altered. Atorvastatin inhibits membrane translocation of rac1 GTPase, which is required for the activation of NAD(P)H oxidase. [2] Atorvastatin (0.1 μM) significantly diminishes NF-κB activation induced by Ang II and TNF-α in mononuclear cells and VSMC. Atorvastatin (1 μM) diminishes MCP-1 expression induced by Ang II, TNF-α and is reversed by Mevalonate only in Ang II-stimulated cells. Atorvastatin (1 μM) diminishes IP-10 expression induced by Ang II and by TNF-α in VSMC, and this reduction is partially reversed by Mevalonate. [3] Atorvastatin and Gemfibrozil metabolites, but not the parent drugs, are potent antioxidants against lipoprotein oxidation. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human Me300 cells M3i3c2N6fG:2b4jpZ:Kh[XO|YYm= NH;3UHc4OiCq M{L0dGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1mOzByIHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9NU4zKM7:TR?= MVKyNlU{OzNzNh?=
human KB cells NGHhUlJEgXSxdH;4bYPDqGG|c3H5 M{exT|czKGh? NEXpToZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMSiClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUGuPVch|ryP MojSNlI2OzN|MU[=
human HeLa cells M1zW[mN6fG:2b4jpZ:Kh[XO|YYm= NIDaWo04OiCq NXW1bplQS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVQvOjJizszN NH;yZVAzOjV|M{OxOi=>
human LN18 cells NUfoXItNS3m2b4TvfIlkyqCjc4PhfS=> MnqyO|IhcA>? MXTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDMUlE5KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKHO3co\peoFtKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZkvKEmFNUC9Ok46KM7:TR?= MUGyNlU{OzNzNh?=
human LNZ308 cells M1zTU2N6fG:2b4jpZ:Kh[XO|YYm= NFSyOXA4OiCq MWPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDMUno{ODhiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME23MlQ1KM7:TR?= NFzvSVUzOjV|M{OxOi=>
human LN229 cells M1zZ[GN6fG:2b4jpZ:Kh[XO|YYm= MVu3NkBp M1zaSGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGxPOjJ7IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuIIP1dpZqfmGuIHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:QC5zIN88US=> M2HubVIzPTN|M{G2
human Caco2 cells NYfNfnpyS3m2b4TvfIlkyqCjc4PhfS=> NWexcnBRPzJiaB?= NWjUZ4U6S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hS2Glb{KgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0yQC55IN88US=> NXK2UFBFOjJ3M{OzNVY>
human HCEC cells M3rSRWN6fG:2b4jpZ:Kh[XO|YYm= NUi3OJBTPzJiaB?= MWrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIR2VEKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKHO3co\peoFtKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9NlAvOyEQvF2= M4fvUlIzPTN|M{G2

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Growth inhibition assay
Cell viability; 

PubMed: 25874930     


The inhibitory effect of increasing concentrations (1–50μM) of atorvastatin calcium on PDGF-BB-induced VSMCs. 

25874930
In vivo

Atorvastatin reduces vascular mRNA expression of p22phox and nox1 and increased aortic catalase expression in statin-treated rats. [2] Atorvastatin inhibits the increase of hsCRP serum levels in the cholesterol-fed rabbits. Atorvastatin inhibits the increase in osteopontin expression throughout the valve leaflet in the hypercholesterolemic aortic valves. [5]

Protocol

Solubility (25°C)

In vitro DMSO 100 mg/mL (86.55 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+35% PEG300+2% Tween 80+ddH2O
For best results, use promptly after mixing.
4mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 1155.34
Formula

2(C33H34FN2O5).Ca

CAS No. 134523-03-8
Storage powder
in solvent
Synonyms N/A

Bio Calculators

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03066466 Recruiting Drug: Atorvastatin|Drug: Methotrexate|Drug: Tacrolimus Acute Myeloid Leukemia|Acute Lymphocytic Leukemia|Myelodysplastic Syndrome Loyola University December 10 2019 Phase 3
NCT03837925 Recruiting Drug: Atorvastatin 40mg Tablet|Drug: Placebo comparator Cardiovascular Diseases French Cardiology Society|Fondation Coeur et Recherche|ICAN Nutrition Education and Research|Fédération francaise de cardiologie June 13 2019 Phase 3
NCT03874156 Recruiting Drug: Atorvastatin 40mg|Drug: Placebo Oral Tablet Statin Adverse Reaction Vestre Viken Hospital Trust|The Hospital of Vestfold|Oslo University Hospital|University of Oslo March 5 2019 Phase 4

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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HMG-CoA Reductase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID