Atorvastatin Calcium

For research use only.

Licensed by Pfizer Catalog No.S2077

3 publications

Atorvastatin Calcium  Chemical Structure

Molecular Weight(MW): 1155.34

Atorvastatin Calcium is an inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol.

Size Price Stock Quantity  
10mM (1mL in DMSO) USD 140 In stock
USD 110 In stock
USD 770 In stock
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Selleck's Atorvastatin Calcium has been cited by 3 publications

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  • Micrographs of hematoxylin and eosin-stained liver sections from untreated and atorvastatin-treated TO mouse. Results of representative experiment of liver specimens incubated in vitro at 37癈 with and without 1.0 礛 atorvastatin for 6 hr is shown. A liver specimen at 0 hr is also shown. Liver structure and cytology are preserved in treated and untreated specimens. Inflammation and cholestasis are absent. (Hematoxylin and eosin, 10?and 40?.

    BMC Pharmacol Toxicol 2013 14, 15. Atorvastatin Calcium purchased from Selleck.

Purity & Quality Control

Choose Selective HMG-CoA Reductase Inhibitors

Biological Activity

Description Atorvastatin Calcium is an inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol.
HMG-CoA reductase [1]
(Cell-free assay)
In vitro

Atorvastatin inhibits pre-proET-1 mRNA expression in a concentration- and time-dependent fashion (60-70% maximum inhibition) and reduces immunoreactive ET-1 levels (25-50%), this inhibitory effect is maintained in the presence of oxidized LDL (1-50 mg/mL). [1] Atorvastatin significantly reduces angiotensin II-induced and epidermal growth factor-induced ROS production in VSMCs. Atorvastatin downregulates mRNA expression of the NAD(P)H oxidase subunit nox1 in VSMCs, whereas p22phox mRNA expression is not significantly altered. Atorvastatin inhibits membrane translocation of rac1 GTPase, which is required for the activation of NAD(P)H oxidase. [2] Atorvastatin (0.1 μM) significantly diminishes NF-κB activation induced by Ang II and TNF-α in mononuclear cells and VSMC. Atorvastatin (1 μM) diminishes MCP-1 expression induced by Ang II, TNF-α and is reversed by Mevalonate only in Ang II-stimulated cells. Atorvastatin (1 μM) diminishes IP-10 expression induced by Ang II and by TNF-α in VSMC, and this reduction is partially reversed by Mevalonate. [3] Atorvastatin and Gemfibrozil metabolites, but not the parent drugs, are potent antioxidants against lipoprotein oxidation. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human Me300 cells MnLPR5l1d3SxeHnjxsBie3OjeR?= M4DOdFczKGh? NFHhXYdEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBO\TNyMDDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVEvOiEQvF2= NV:5dW9kOjJ3M{OzNVY>
human KB cells MWHDfZRwfG:6aXRCpIF{e2G7 MWS3NkBp NEfsWJVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMSiClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUGuPVch|ryP NXjpRnBFOjJ3M{OzNVY>
human HeLa cells MV;DfZRwfG:6aXRCpIF{e2G7 NEfme|Q4OiCq NHny[3ZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\UyjIHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9OE4zOiEQvF2= NWHHWHl1OjJ3M{OzNVY>
human LN18 cells NIj5PFdEgXSxdH;4bYPDqGG|c3H5 NVH5OYtpPzJiaB?= MkLQR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUG4yQCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC|dYL2bZZidCCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NiCLQ{WwQVYvQSEQvF2= MXGyNlU{OzNzNh?=
human LNZ308 cells NI\KUVVEgXSxdH;4bYPDqGG|c3H5 NVLtbnV{PzJiaB?= MnHSR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUG5bOzB6IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9O{41PCEQvF2= M4XuU|IzPTN|M{G2
human LN229 cells Mn;vR5l1d3SxeHnjxsBie3OjeR?= M1SwbVczKGh? M3n5ZmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGxPOjJ7IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuIIP1dpZqfmGuIHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:QC5zIN88US=> NVfjZ3RLOjJ3M{OzNVY>
human Caco2 cells MV;DfZRwfG:6aXRCpIF{e2G7 MmPqO|IhcA>? M4PKO2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGNi[29{IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9NVgvPyEQvF2= M3y4O|IzPTN|M{G2
human HCEC cells NGO5WoVEgXSxdH;4bYPDqGG|c3H5 M3m5VVczKGh? M4TFXGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhETUNiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxic4Xyeol3[WxiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0zOC5|IN88US=> M{XIUVIzPTN|M{G2

... Click to View More Cell Line Experimental Data

Methods Test Index PMID
Growth inhibition assay
Cell viability; 

PubMed: 25874930     

The inhibitory effect of increasing concentrations (1–50μM) of atorvastatin calcium on PDGF-BB-induced VSMCs. 

In vivo

Atorvastatin reduces vascular mRNA expression of p22phox and nox1 and increased aortic catalase expression in statin-treated rats. [2] Atorvastatin inhibits the increase of hsCRP serum levels in the cholesterol-fed rabbits. Atorvastatin inhibits the increase in osteopontin expression throughout the valve leaflet in the hypercholesterolemic aortic valves. [5]


Solubility (25°C)

In vitro DMSO 100 mg/mL (86.55 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+35% PEG300+2% Tween 80+ddH2O
For best results, use promptly after mixing.

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 1155.34


CAS No. 134523-03-8
Storage powder
in solvent
Synonyms N/A
Smiles [Ca++].CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(=C([N]1CCC(O)CC(O)CC([O-])=O)C3=CC=C(F)C=C3)C4=CC=CC=C4.CC(C)C5=C(C(=O)NC6=CC=CC=C6)C(=C([N]5CCC(O)CC(O)CC([O-])=O)C7=CC=C(F)C=C7)C8=CC=CC=C8

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Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation (Different batches have different solubility ratios, please contact Selleck to provide you with the correct ratio)
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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04388501 Not yet recruiting Drug: JNJ-70033093|Drug: Atorvastatin Healthy Janssen Pharmaceutica N.V. Belgium July 9 2020 Phase 1
NCT03066466 Recruiting Drug: Atorvastatin|Drug: Methotrexate|Drug: Tacrolimus Acute Myeloid Leukemia|Acute Lymphocytic Leukemia|Myelodysplastic Syndrome Loyola University December 10 2019 Phase 3
NCT03837925 Recruiting Drug: Atorvastatin 40mg Tablet|Drug: Placebo comparator Cardiovascular Diseases French Cardiology Society|Fondation Coeur et Recherche|ICAN Nutrition Education and Research|Fédération francaise de cardiologie June 13 2019 Phase 3

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HMG-CoA Reductase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID