|| Methyl p-tert-butylphenylacetate
||Methyl 4-tert-butylphenylacetate is a flavouring ingredient with a roasted, chocolate-like flavour.
(+)-Medicarpin, a pterocarpan, is a type of isoflavonoid isolated from several medicinal plant species with various biological effects.
(+)-Medioresinol Di-O-β-D-glucopyranoside is a lignan glucoside with strong inhibitory activity of 3', 5'-cyclic monophosphate (cyclic AMP) phosphodiesterase.
(-)-Maackiain, a Kujin-derived anti-allergic compound, disrupts the interaction of Hsp90 with PKCδ, resulting in the suppression of phorbol 12-myristate 13-acetate (PMA)-induced up-regulation of H1R gene expression in HeLa cells.
||(-)-Menthol is a levo isomer of menthol and used as a cooling agent that strongly activates TRPM8.
(±)-Methyl Jasmonate (MeJA, Methyl jasmonate, Methyl 2-(3-oxo-2-(pent-2-en-1-yl)cyclopentyl)acetate), a phytohormone that acts as a vital cell regulator in plants, is a new candidate for the treatment of Inflammatory bowel diseases (IBDs), modulating the expression of the major classes of caspase-type protease families.
(±)-ML 209 is a RORγt inverse agonist with an IC50 of 460 nM. (±)-ML 209 suppresses Th17 cell differentiation and IL17A expression in vitro.
||1-methoxy PMS (1-Methoxy-5-methylphenazinium methyl sulfate) is stable electron-transport mediator between NAD(P)H and tetrazolium dyes.
||1-Methyl-2-pyrrolidone (NMP, N-Methylpyrrolidone) is a highly refined solvent and intended for use in biological, proteomics, and other sensitive assays.
1-Methyl-3-nitro-1-nitrosoguanidine (N-Methyl-N-nitroso-N′-nitroguanidine, Methylnitronitrosoguanidine, MNNG, MNG) is a biochemical tool used experimentally as a carcinogen and mutagen.
||1-Methyl-7-nitroisatoic anhydride (1M7)
||1-methyl-7-nitroisatoic anhydride (1M7) is a commonly applied RNA-SHAPE electrophile for probing 2'-hydroxyl reactivity.
||1-Methylnaphthalene is an organic compound.
1-Methylnicotinamide (1-MNA, 3-Carbamoyl-1-methylpyridin-1-ium, Trigonellamide) chloride is an active endogenous metabolite of nicotinamide that exhibits anti-inflammatory and anti-thrombotic activities. 1-Methylnicotinamide enhances tumor vasculature formation and markedly increases prostacyclin (PGI2) generation.
||1-Methylpyrrolidine is extensively used in the synthesis of pyrrolidine based ionic liquids.
10-Methoxycamptothecin is a natural bioactive derivative of camptothecin (CPT) isolated from <i>Camptotheca acuminata</i>, and has been confirmed to possess high anti-cancer properties.
||11(α)-Methoxysaikosaponin F is a triterpenoid saponin isolated from Bupleurum marginatum Wall.ex DC(ZYCH). 11(α)-Methoxysaikosaponin F has an IC50 of 387.7 nM with viability of hepatic stellate cells-T6 (HSCs-T6).
||11-Mercaptoundecanoic acid (MUA) is a thiol-containing fatty acid, which has been described in the preparation of self-assembled monolayers (SAMs), mixed monolayers, and metal-associated nanoparticles.
13-Methylberberine chloride (13-Methylberberinium chloride), a berberine analogue, has anti-adipogenic and antitumor activities. 13-Methylberberine chloride (13-Methylberberinium chloride) increases production of IL-12 and inhibits the expression of iNOS at posttranscriptional level in macrophages activated with LPS.
||2-(4-Methoxyphenyl)acetic acid (p-Anisylacetic acid, 4-Methoxyphenylacetic acid) is a 4-O-Methylated catecholamine metabolite found in normal human urine, cerebrospinal fluid and brain tissue.
2-Mercaptobenzothiazole (Benzothiazole-2-thiol, 2-MBT, Mercapto-2-benzothiazole) is an exceptionally potent inhibitor of banana polyphenoloxidase and can significantly delay the onset of substrate oxidation at concentrations as low as 100 nM.
||2-Methoxy-1,4-naphthoquinone, isolated from the leaves of Impatiens glandulifera, specifically suppressed the expression of PKC βI, δ, and ζ in a concentration-dependent manner in Raji cells.
||2-Methoxybenzoic acid (o-Anisic acid) is a flavouring agent.
||2-methoxycinnamaldehyde (O-methoxycinnamaldehyde), found in ceylan cinnamon, is a flavouring ingredient.
||2-Methoxycinnamic acid (AI3-11206) is a cinnamic acid with magnetic properties.
||2-Methoxyestradiol (2-MeOE2, NSC 659853, 2-ME2) depolymerizes microtubules and blocks HIF-1α nuclear accumulation and HIF-transcriptional activity. 2-Methoxyestradiol induces both autophagy and apoptosis in various carcinogenic cell lines. Phase 2.
||2-Methyl-1-propanol is widely used as an solvent for chemical reaction and an useful material for organic synthesis.
||2-Methyl-3-Pentanone is an aliphatic ketone with used as a reagent in organic chemistry and as a solvent.
||2-Methyl-4-pentenoic acid is a branched-chain fatty acid.
||2-Methylenebutyrolactone (Tulipalin A, MBL, α-methylene-γ-butyrolactone), also known as α-methylene-γ-butyrolactone (MBL) (Tulipalin A), belongs to the class of sesquiterpene lactone family and is considered as cyclic analog of most common vinyl monomer methyl methacrylate (MMA).
||2-Methylheptanoic Acid is a flavouring ingredient.
||2-Methylhexanoic acid is a flavouring ingredient.
||2-Methyllactic acid (2-Hydroxyisobutyric acid, Acetonic acid) is a metabolite of methyl tertiary-butyl ether.
||2-Methylglutaric acid (alpha-Methylglutaric acid) is a metabolite of succinic acid, a citric acid cycle intermediate.
2-Methylpentanoic acid (2-Methylvaleric acid, Methylpropylacetic acid) is a short-chain fatty acid that exists in various foods including cheeses, cherimoya, lamb and mutton, and so on. 2-Methylpentanoic acid is a flavor compound used for food-flavor ingredient, fragrances.
||2-Methylsuccinic acid (Pyrotartaric acid, 2-methylbutanedioic acid, propane-1,2-dicarboxylic acid, Methylsuccinate) is a normal metabolite found in human fluids.
||2-Methyltetrahydrofuran-3-one is a volatile constituent of the aroma complex of roasted coffee.
||2-Methylvaleraldehyde is a flavouring ingredient.
3'-Methoxypuerarin (3'-MOP) is an isoflavone extracted from radix puerariae that shows neuron protection activity.
||3-(3-Methoxyphenyl)propionic acid is a naturally occurring human metabolite, It is an organic acid and excreted in human urine.
||3-(Methylthio)propionic acid (3-methylthiopropionate, 4-Thiapentanoic acid, 3-Methylsulfanylpropionic acid) is a thia fatty acid acid consisting of propionic acid with a methylthio substituent at the 3-position and an intermediate in mammalian methionine metabolism in vitro.
||3-Maleimidopropionic acid is an alkyl chain-based PROTAC linker that is applicable to the synthesis of PROTACs.
||3-Methoxybenzamide (3-MBA) is a competitive inhibitor of poly(ADP-ribose) synthetase with Ki values of less than 2 μM and also inhibits ADP-ribosyltransferase (ADPRT)
||3-Methoxybenzoic acid (m-Anisic acid, 3-Methoxybenzoate, 3-Anisic acid, m-Methylsalicylic acid) is a food additive that acts as a flavouring ingredient.
||3-Methoxyphenylacetic acid (m-Methoxyphenylacetic acid, P-Methoxyphenylacetic acid, Anisylacetic acid, m-OMePAA) is a monocarboxylic acid.
3-Methoxytyramine (3-O-methyl Dopamine, 3MT) hydrochloride, a major extracellular metabolite of dopamine, is a neuromodulator that in certain situations may be involved in movement control.
||3-methyltoxoflavin is an effective inhibitor of protein disulfide isomerase (PDI) with IC50 of 170 nM.
||3-Methyl-2-butanol is a flavouring ingredient. It is found in apple, cider, grape, honey, wine, orange juice and strawberry.
3-Methyl-2-buten-1-ol (Prenol, Prenyl alcohol, Dimethylallyl alcohol) is an endogenous metabolite.
||3-Methyl-2-oxobutanoic acid (alpha-Ketoisovalerate, alpha-Ketoisovaleric acid), a neurotoxin, an acidogen and a metabotoxin, is an abnormal metabolite that arises from the incomplete breakdown of branched-chain amino acids.
||3-Methyladenine (3-MA, NSC 66389) is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM in HeLa cells; blocks class I PI3K consistently, whereas suppression of class III PI3K is transient, and also blocks autophagosome formation. 3-Methyladenine (3-MA) is successfully used to suppress mitophagy. Solutions of 3-MA are best fresh-prepared by heating.
||3-Methyladipic acid (3-Methyladipate, β-Methyladipic acid, β-Methyladipate) is a metabolite of the catabolism of phytanic acid.
||3-Methylbutanoic acid (Isovaleric acid, Delphinic acid, 3-Methylbutyric acid, Isopentanoic acid, β-methylbutyric acid) is a natural fatty acid found in a wide variety of plants and essential oils. It has a strong pungent cheesy or sweaty smell, but its volatile esters have pleasing scents and are used widely in perfumery.
3-Methylglutaric acid (MGA, 3MG acid) is a conspicuous C6 dicarboxylic organic acid that can be used as a single solid-state NMR standard compound to perform all calibration steps except for magnet shimming.
||3-Methylpyrazole (3-MP) is a weak or non-inhibitor of alcohol dehydrogenase.
||3-Methylvaleric acid is a flavouring ingredient.
||3-Methylxanthine (3-MX), a 3-alkylxanthine, is an inhibitor of cyclic guanosine monophosphate (GMP) phosphodiesterase (PDE) with IC50 of 920 μM on guinea-pig isolated trachealis muscle.
||4'-Methoxychalcone, found in citrus, is chalcone derivative that has shown diverse pharmacological properties, including anti-tumor and anti-inflammatory activities. 4'-Methoxychalcone significantly enhanced adipocyte differentiation, in part, by its potent effects on PPARγ activation and by its reverse effect on TNF-α.
||4'-Methoxypuerarin, an isoflavone diethylene glycol, is isolated from Pueraria lobata.
||4-Methoxyresveratrol is a stibenoid found in the Chinese herb Gnetum cleistostachyum. 4'-Methoxyresveratrol alleviates AGE-induced inflammation through suppressing RAGE-mediated MAPK/NF-κB signaling pathway and NLRP3 inflammasome activation.
||4-Maleimidobutyric acid is an alkyl chain-based PROTAC linker that is applicable to the synthesis of PROTACs.
||4-Methoxysalicylaldehyde (2-Hydroxy-4-methoxybenzaldehyde), a naturally occurring product, has a range of industrial applications in the preparation of organic compounds, drugs and therapeutic agents.
||4-Methoxysalicylic acid (2-Hydroxy-p-anisic Acid), an arabinose derivative, is used in the synthesis of 1,3,4-oxadiazole derivatives.
||4-Methyl-2-oxovaleric acid (Ketoleucine, 4-MOV, KIC, 4-Methyl-2-oxopentanoic acid, alpha-Ketoisocaproic acid, alpha-ketoisocaproate, 2-Oxoisohexanoate) is released by Astrocytes to neurons and can be reaminated by aminotransferase to leucine. 4-Methyl-2-oxovaleric acid reduces the rate of protein degradation in skeletal muscle. 4-Methyl-2-oxovaleric acid acts as an uncoupler of oxidative phosphorylation (OXPHOS) and as a metabolic inhibitor possibly through its inhibitory effect on alpha-ketoglutarate dehydrogenase (oxoglutarate dehydrogenase complex, OGDC) activity.
||4-Methyl-2-pentanone is an organic solvent used in industry.
||4-Methyl-n-octanoic Acid is a flavouring ingredient.
||4-Methylbenzylidene camphor (Enzacamene, 4-MBC) is an organic camphor derivative that is used in the cosmetic industry for its ability to protect the skin against UV, specifically UV B radiation.
||4-Methylcatechol (P-Methylcatechol, 3,4-Dihydroxytoluene, Homocatechol) is an inducer of nerve growth factor. It is used to synthesize antimicrobial and antioxidant.
||4-methylesculetin is one of the coumarin derivatives with great anti-oxidant and anti-inflammatory activities. 4-Methylesculetin inhibits myeloperoxidase (MPO) activity and reduces IL-6 level.
||4-Methylsalicylic acid (m-Cresotic acid, 2-Hydroxy-4-methylbenzoic acid, m-Cresotinic acid, 2-Hydroxy-p-toluic acid) is used to inhibit the medium chain acyl-CoA synthetase.
||4-Methylumbelliferone is a hyaluronic acid (HA) synthesis inhibitor with an IC50 of 0.4 mM.
||4-Methylvaleric acid (Isocaproic acid, Isocaproate, 4-Methylpentanoate, 4-Methylpentanoic acid) is an important metabolite in early placentas enabling the convertion from cholesterol to pregnenolone to Dehydroepiandrosterone (DHEA).
||4-MMPB, a selective inhibitor of 15-lipoxygenase (15-LO) with an IC50 of 18 μM, shows IC50s of 19.5 μM and 19.1 μM for soybean 15-lipoxygenase (SLO) and human 15-lipoxygenase-1 (15-LOX-1), respectively.
4'-Methoxyagarotetrol is a natural compound that can be found in Aquilaria sinensis (Lour.).
||5-Maleimidovaleric acid is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
||5-methoxyflavone is a novel DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity.
||5-Methoxysalicylic acid is a chemical compound belongs to the class of organic compounds known as m-methoxybenzoic acids and derivatives.
||5-Methoxytryptamine (Mexamine, Methoxytryptamine) is a tryptamine derivative that acts as a full agonist at the 5-HT1, 5-HT2, 5-HT4, 5-HT6, and 5-HT7 receptors.
||5-Methyl furfural is an important chemical intermediate.
||5-Methyl-2'-deoxycytidine (5-Me-dC, 5-Methyldeoxycytidine, 5MedCyd) is a minor component found in most eukaryotic DNA.
||5-Methyl-7-methoxyisoflavone is a chemical compound commonly used as a bodybuilding supplement.
||5-Methylcytidine is a modified nucleoside derived from 5-methylcytosine. It is found in ribonucleic acids of animal, plant, and bacterial origin.
||5-Methylcytosine, a methylated form of the DNA base cytosine, is a major epigenetic mark in the nuclear DNA in mammals and may be involved in the regulation of gene transcription.
||5-Methyluridine (Ribothymidine, Ribosylthymine, Thymine riboside) is a pyrimidine nucleoside that acts as an human endogenous metabolite.
||6-Maleimidohexanoic acid N-hydroxysuccinimide ester
||6-Maleimidohexanoic acid N-hydroxysuccinimide ester (ECMS) is a useful protective group in antibody drug conjugates (ADCs).
||6-Mercaptopurine (6-MP) Monohydrate
||6-Mercaptopurine (6-MP) Monohydrate is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.
||6-Methoxy-2-naphthoic acid (6-Methoxy-2-naphthalenecarboxylic acid) is an modulator of NMDAR.
||6-Methoxydihydroavicine (6-Methoxy Dihydrosanguinarine) is an lkaloid isolated from the fruits of M.cordata.
||6-Methoxydihydrosanguinarine, an lkaloid isolated from the fruits of M.cordata, exhibits strong cytotoxicity against MCF-7 and SF-268 cell lines with IC50 of 0.61 μM and 0.54 μM, respectively.
6-Methoxyluteolin is a natural flavonoid isolated from <i>Eupatorium ballotaefolium</i> HBK with potent anti-inflammatory activities.
6-Methoxytricin is a flavonoid isolated from <i>Artemisia iwayomogi</i>. 6-Methoxytricin is an inhibitor on <b>aldose reductase (AR) </b> and <b>advanced glycation endproduct (AGE)</b> formation activities with IC<sup>50</sup> values of 30.29 μM and 134.88 μM, respectively. 6-Methoxytricin has potential as an anti-diabetic complications agent.
||6-Methylcoumarin (Toncarine), a synthetic fragrance widely used in cosmetics, belongs to the class of organic compounds known as coumarins and derivatives.
||7-Methoxy-4-methylcoumarin is a coumarin derivative and fluorescent label. 7-Methoxy-4-methylcoumarin has an antimicrobial activitiy against both gram positive and gram negative bacterial stains. 4-Methylherniarin displays good activity against B. subtilis and S.sonnei with IC50 of 11.76 μg/ml and 13.47 μg/ml, respectively.
||7-Methoxycoumarin (Herniarine), also known as Herniarin, is a methoxy derivative of coumarin and substrate for dealkylase. It has been used in the synthesis of anti-first-pass effect compounds and detergents.
||7-Methoxyisoflavone (MIF) is a potent activator of adenosine monophosphate-activated protein kinase (AMPK).
7-Methoxyrosmanol (7-O-Methoxyrosmanol) is a phenolic diterpene separated from rosemary.
||7-Methylcoumarin can inhibit the growth of S. aureus and the growth of Gram-positive bacteria within a concentration of 0.8–3.6 μg/ml, and also has a strong hepatoprotective activity.
||9'''-Methyl salvianolate B
9'''-Methyl salvianolate B is an active constituent in ethanol extract of <i>Radix Salviae Miltiorrhizae</i>.
||9''-Methyl salvianolate B
||9''-Methyl salvianolate B (9'-methyllithospermate B, 9'-Methyl lithospermate B, 9'''-Methyl salvianolate B) is an active constituent in ethanol extract of Radix Salviae Miltiorrhizae.
9-Methoxycamptothecin, isolated from <i>Nothapodytes foetida</i>, has antitumor activities through topoisomerase inhibition.
9-Methoxycanthin-6-one is present in intact plant parts and in callus tissues of different explants with anti-tumour activity.
||M-31850 is a potent, selective and competitive inhibitor of β-hexosaminidase (Hex) with IC50 of 6.0 μM and 3.1 μM for human HexA and human HexB, respectively. M-31850 also competitively inhibits β-N-acetyl-D-hexosaminidase of Hex2 with Ki of 2.5 μM.
||m-3M3FBS is a potent activator of phospholipase C (PLC) that stimulates a transient intracellular calcium concentration increase in neutrophils. m-3M3FBS induces apoptosis in monocytic leukemia cells.
||m-Cresol is an important chemical material, which is mainly derived from low-temperature coal tar. m-Cresol is used as an intermediate in the production of other chemicals.
||m-Dichlorobenzene is an intermediate for agrochemicals and pharmaceuticals.
||m-PEG10-alcohol (Decaethylene glycol monomethyl ether) is a non-cleavable 10-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). m-PEG10-alcohol is also a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs.
||m-PEG11-Amino is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
||m-PEG12-amine is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. m-PEG12-amine is also a non-cleavable 12-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
||m-PEG16-alcohol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||m-PEG2-Amine is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
||m-PEG2-azide is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||m-PEG2-Tos is an uncleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
||m-PEG3-Amine is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
||m-PEG3-CH2CH2COOH is a non-cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
||m-PEG3-alcohol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||m-PEG3-Tos is a PEG-based PROTAC linker that is applicable to the synthesis of Silymarin.
||m-PEG4-Br is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs) for Trastuzumab. m-PEG4-Br is placed distally from the monomethyl auristatin E (MMAE) payload to yield an ADC with altered hydrophilicity, antigen binding, and in vitro potency.
||m-PEG5-acid is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||m-PEG5-CH2CH2COOH is a PEG-based based PROTAC linker that is applicable to the synthesis of PROTACs.
||m-PEG5-NH2 is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||m-PEG6-Amine is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
||m-PEG6-Br is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||m-PEG6-CH2CH2COOH is a PEG-based based PROTAC linker that is applicable to the synthesis of PROTACs.
||m-PEG6-NHS ester is a non-cleavable 5-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
||m-PEG6-O-CH2COOH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||m-PEG7-alcohol (O-Methyl-heptaethylene glycol) is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||m-PEG7-Amine is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
||m-PEG7-CH2COOH is a non-cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
||m-PEG8-Amine is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
||m-PEG8-NHS ester is a non-cleavable 8-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
||m-PEG8-thiol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||m-PEG9-Amine is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
||m-Tolyl acetate is a pharmaceutical intermediate and antiseptic.
||M1001 is a weak agonist of hypoxia-inducible factor-2α (HIF-2α) that binds to the HIF-2α PAS-B domain with Kd of 667 nM.
||M2I-1 is an inhibitor of Mad2 (mitotic arrest deficient 2) targeting the binding of Mad2 to Cdc20, an essential protein-protein interaction (PPI) within the SAC (spindle assembly checkpoint).
||M2N12 is a potent and highly selective cell division cycle 25C protein phosphatase (Cdc25C) inhibitor with an IC50 value of 0.09 μM, also shows promising activity against Cdc25A and Cdc25B with IC50 values of 0.53 μM and 1.39 μM, respectively.
||M4076 is an ATP-competitive inhibitor of the Ataxia telangiectasia mutated (ATM) kinase with IC50 of 0.2 nM, which targets tumor cell survival and growth by inhibiting double-strand break (DSB) repair as well as checkpoint control.
||M435-1279 is a UBE2T inhibitor, inhibiting the Wnt/β-catenin signaling pathway hyperactivation through blocking UBE2T-mediated degradation of RACK1.
||MA-0204 is a potent, highly selective and orally available modulator of peroxisome proliferator activated receptor δ (PPARδ) with EC50 of 0.4 nM, 7.9 nM and 10 nM for human, mouse and rat PPARδ, respectively. MA-0204 is used as a potential treatment for Duchene Muscular Dystrophy (DMD).
||Maackiain (Demethylpterocarpin) is a pterocarpan that is widely distributed in leguminous plants. It has anticancer and antimicrobial effects.
||MAC-545496 is a nanomolar glycopeptide-resistance-associated protein R(GraR) inhibitor with strong binding affinity to the full-length GraR protein (Kd ≤ 0.1 nM). MAC-545496 can reverse β-lactam resistance in methicillin-resistant strains and synergize with CAMPs. MAC-545496 shows remarkable activity in macrophages and attenuates S. aureus virulence in a G. mellonella larvae infection model.
||mAChR-IN-1 is a muscarinic cholinergic receptor (mAChR) antagonist with IC50 of 17 nM.
||Macitentan (ACT 064992)
||Macitentan (ACT 064992) is an orally active, non-peptide, dual ETA/ETB (endothelin) receptor antagonist with IC50 of 0.5 nM/391 nM.
||Macleaya Cordata Extract
||Macranthoidin B (Macranthoiside I) is a major bioactive saponin in rat plasma after oral administration of extraction of saponins from Flos Lonicerae.
||Macrocyclic Compound Library
||A unique collection of 188 macrocyclic compounds used for high throughput screening(HTS) and high content screening(HCS).
||Madecassic acid (Brahmic acid), a natural triterpene first isolated from C. asiatica, has diverse anti-inflammatory and anti-diabetic effects, blocking NF-κB activation in macrophages and causing by iNOS, COX-2, TNF-alpha, IL-1beta and IL-6 inhibition.
||Madecassoside (Asiaticoside A) is the main active triterpene constituent of Centella asiatica herbs, a traditional Chinese medicine for wound healing and scar management.
||Madrasin (DDD00107587) is a potent and cell-penetrant pre-mRNA splicing inhibitor. Madrasin interferes with the early stages of spliceosome assembly and stalls spliceosome assembly at the A complex.
||Maduramicin, which could be isolated from the actinomycete Actinomadura rubra, is an antiprotozoal agent used in veterinary medicine to prevent coccidiosis.
||Mafenide Acetate is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy.
||Mafenide is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy.
||Magnesium 2-aminoacetate (Magnesium glycinate) is essential for DNA and RNA synthesis, cellular repair, and maintaining the antioxidant status of the cell.
Magnesium chloride can reduce the activated thromboplastin times.
||Magnesium lactate trihydrate
||Magnesium lactate, the magnesium salt of lactic acid, is a mineral supplement that is added to some food and beverages as an acidity regulator.
||Magnoflorine (Escholin, Thalictrin), an important compound in Aristolochia, was usually used as an anxiolytic chemical. It shows significant antioxidant activity as a DPPH free radical scavenger and inhibits α-tyrosinase.
||Magnoflorine (Escholine, Thalictrine, Corytuberine methochloride), isolated from the rhizome of Sinomenium acutum and from Pachygone ovata, is usually used as an anxiolytic chemical with anti-oxidant, α-tyrosinase inhibitory and anti-inflammationary activities.
Magnoflorine iodide, an aporphine alkaloid found in Acoruscalamus, reduces the formation of C. albicans biofilm. Magnoflorine iodide has anti-fungal, anti-antidiabetic and anti-oxidative activity.
||Magnolia Bark Extract
||Magnolia Obovata Extract
||Magnoliae Flos Extract
||Magnolin is a natural compound abundantly found in Magnolia flos targeting ERK1 (IC50=87 nM) and ERK2 (IC50=16.5 nM) and inhibits cell transformation induced by tumor promoters such as epidermal growth factor (EGF).
||Magnolol (NSC 293099) is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties. It can block TNF-α-induced NF-KB activation.
Magrolimab (anti-CD47) (5F9, GS-4721,Hu5F9 G4,ONO 7913) is a first-in-class macrophage immune checkpoint inhibitor that mainly binds to N-terminal pyroglutamate of CD47.
Mahanimbine is an orally active alkaloid from curry leaves. Mahanimbine inhibits progression of high-fat diet (HFD)-induced metabolic complications in mice.
||MAK683 (EED inhibitor-1, example 2) is an inhibitor of embryonic ectoderm development (EED). MAK683 exhibits IC50 of 59 nM, 89 nM and 26 nM in EED Alphascreen binding, LC-MS and ELISA assay, respectively.
||Mal-amido-PEG2-C2-acid is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Mal-amido-PEG2-NHS ester is a non-cleavable ADC linker containing a maleimide group and an NHS ester. The NHS ester can label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.
||Mal-amido-PEG8-C2-acid is a noncleavable ADC linker.
||Mal-C2-NHS ester is a non-cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
||Mal-NH-Boc is an alkyl/ether-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Mal-PEG2-acid is a non-cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). Mal-PEG2-acid can be conjugated to Tubulysin and its derivative cytotoxic molecule.
||Mal-PEG2-NHS ester is a non-cleavable ADC linker consists of a Maleimide group, 2-unit PEG and an NHS ester.
||Mal-PEG3-NHS ester is a noncleavable ADC linker with a Maleimide group that is used for making antibody-drug conjugates (ADCs).
||Mal-PEG6-NHS ester is a non-cleavable ADC linker containing a Maleimide group, 6-unit PEG and a NHS ester.
||Mal-PEG4-NHS ester is a non-cleavable ADC linker containing a Maleimide group, 4-unit PEG and an NHS ester.
||Malachite green (Aniline green, Basic green 4, Diamond green B, Victoria green B) is a synthetic dyestuff and antimicrobial with potential carcinogenicity.
||Malantide is a synthetic dodecapeptide derived from the site phosphorylated by cAMP-dependent protein kinase (PKA) on the β-subunit of phosphorylase kinase, which is a highly specific substrate for PKA with a Km of 15 μM.
||MALAT1-IN-1 (TC SL C5) is a potent and specific inhibitor of Malat1 (Metastasis-associated lung adenocarcinoma transcript 1) that modulates Malat1 downstream genes in a dose-dependent manner without affecting expression of nuclear enriched abundant transcript 1 (Neat1).
||Malaytea Scurfpea Extract
Maleamic acid ((Z)-4-Amino-4-oxobut-2-enoic acid) is an endogenous metabolite.
Maleic acid inhibits glutamate decarboxylase (GAD) activity, thus enhances acid sensitivity of Listeria monocytogenes. Maleic acid affects the extracellular GABA levels.
||Maleimide exhibits fluorescence quenching ability and can be used for the specific detection of thiol analytes as fluorogenic probes. Maleimide is also used for production of antibody-drug conjugate (ADC) which is used in cancer research.
||Malic acid (Hydroxybutanedioic acid, 2-Hydroxysuccinic acid) is a common, naturally occurring ingredient in many foods. It is the main acid found in apples and other fruits.
Malonic acid (MOA), one of the major dicarboxylic acids (DCAs) in aerosols, has been identified experimentally and computationally to be a strong acid. Malonic acid (MOA) acts as a mediate bridge for the formation of pure SA-A-based clusters.
||Malotilate (NKK105) is a drug used for the treatment of liver cirrhosis. Malotilate is a liver protein metabolism improved compound, which selectively inhibit the 5-lipoxygenase.
||Maltitol (Maltisorb, 4-O-α-glucopyranosyl-D-sorbitol) is a sugar alcohol (polyol) used as a sugar substitute. It is especially useful in the production of sweets, including sugarless hard candies, chewing gum, chocolates.
||Maltohexaose (Amylohexaose) is a polysaccharide with 6 units of glucose and can be classified as a maltodextrin.
||Maltol (Larixinic acid, Palatone, Veltol) is a naturally occurring organic compound that is flavour enhancer and flavouring agent.
||Maltose (Maltobiose, Malt Sugar, Beta-Maltose, D-Maltose), an non-essential nutrient that provides energy, is an intermediate in the intestinal digestion of glycogen and starch, and is found in germinating grains (and other plants and vegetables).
||Maltose (Maltobiose, Malt Sugar, Beta-Maltose, D-Maltose) monohydrate, an non-essential nutrient that provides energy, is an intermediate in the intestinal digestion of glycogen and starch, and is found in germinating grains (and other plants and vegetables).
||Maltotetraose, found in many foods, belongs to the class of organic compounds known as oligosaccharides.
||Maltotriose is a trisaccharide consisting of three glucose molecules linked with α-1,4 glycosidic bonds. It is a common oligosaccharide metabolite found in human urine after maltose ingestion or infusion.
||Malt fruit Extract
||Malvae Fructus Extract
Malvidin chloride is a bioactive compound isolated from <i>Oryza sativacv. Heugjinjubyeo</i>. Malvidin shows cytotoxicity through the arrest of the G2/M phase of cell cycle and induction of apoptosis. Malvidin can be used for the research of cancer.
||Mang Grass Extract
||Manganese chloride occurs in nature as the mineral. It is used as a precursor for other manganese compounds.
||Mangiferin (Alpizarin, Chinomin, Hedysarid) is a bioactive compound that demonstrates many health perspectives and has been used to prepare medicinal and food supplements. Mangiferin is a Nrf2 activator. Mangiferin suppresses nuclear translocation of the NF-κB subunits p65 and p50.
||Mango leaf Extract
||Manidipine is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive.
||Manidipine 2HCl (CV-4093) is a HCl salt form of Manidipine, which is a calcium channel blocker with IC50 of 2.6 nM, used clinically as an antihypertensive. Phase 4.
||Manogepix (E1210, MGX, APX001A) is a broad-spectrum and orally active antifungal agent that inhibits Gwt1/Gwt1p (GPI-anchored wall transfer protein 1), a protein that plays an important role in fungal cell wall integrity.
||Mantis egg-case Extract
||MAO-B-IN-2 is a selective and competitive inhibitor of MAO-B and BChE with IC50 values of 0.51 and 7.00 μM, respectively.
Maohuoside A is a single compound isolated from the <i>E. koreanum</i> that potently promotes osteogenesis.
||MAPK Inhibitor Library
||A unique collection of 258 small molecule inhibitors used for MAPK signaling research.
||Maprotiline HCl is a selective noradrenalin re-uptake inhibitor, used in the treatment of depression.
||Maraviroc (UK-427857) is a CCR5 antagonist for MIP-1α, MIP-1β and RANTES with IC50 of 3.3 nM, 7.2 nM and 5.2 nM in cell-free assays, respectively. Maraviroc is used in the treatment of HIV infection.
||Marbofloxacin is a potent antibiotic inhibiting bacterial DNA replication.
||Mardepodect (PF-2545920) is a potent and selective PDE10A inhibitor with IC50 of 0.37 nM, with >1000-fold selectivity over the PDE.
||Marimastat (BB-2516, TA2516) is a broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 with IC50 of 3 nM, 5 nM, 6 nM, 9 nM and 13 nM, respectively. Phase 3.
Marinobufagin is a natriuretic and vasoconstrictor agent found in the systemic circulation of mammalian species.
||MARK4 inhibitor 1
||MARK4 inhibitor 1 is a potent microtubule affinity-regulating kinase 4 (MARK4) inhibitor, with an IC50 of 1.54 μM for MARK4 inhibition assay.
||Marlea platanifolia Extract
||Marmesin (S-(+)-Marmesin, (+)-Marmesin, (S)-Marmesin) is a natural coumarin with COX-2 and 5-LOX dual inhibitory activity.
Maropitant citrate is a novel neurokinin type-1 (NK1) receptor antagonist with anti-inflammatory and analgesic properties.
||Marrubiin, isolated from Marrubium vulgare, exhibits vasorelaxant and antioedematogenic activity.
||Marsdeniae Tenocissimae Extract
||Masitinib is a novel inhibitor for Kit (c-Kit) and PDGFRα/β with IC50 of 200 nM and 540 nM/800 nM, weak inhibition to ABL and c-Fms. Phase 3.
||Masitinib mesylate (AB-1010 mesylate) is a potent, orally bioavailable, and selective inhibitor of c-Kit with IC50 of 200 nM for human recombinant c-Kit, also inhibits PDGFRα/β with IC50s of 540/800 nM, Lyn with IC50 of 510 nM for LynB, and, to a lesser extent, FGFR3 and FAK.
||Maslinic Acid (Crategolic Acid, 2α-Hydroxyoleanoic Acid), a Natural Triterpene, exerts a wide range of biological activities, i.e. antitumor, antidiabetic, antioxidant, cardioprotective, neuroprotective, antiparasitic and growth-stimulating. MA significantly suppresses the DNA-binding activity of NF-κB p65 in LPS-induced RAW 264.7 cells.
||Massa Medicata Fermentata Extract
||Masson pine needle Extract
||Mavacamten (MYK-461, SAR439152) is a small-molecule modulator of cardiac myosin that targets the underlying sarcomere hypercontractility of hypertrophic cardiomyopathy (HCM), one of the most prevalent heritable cardiovascular disorders.
||Mavacoxib (Trocoxil) is a selective, long-acting cyclooxygenase-2 (COX-2) inhibitor. Mavacoxib is a novel nonsteroidal anti-inflammatory drug (NSAID).
||Maytansinol (Ansamitocin P-0) is an inhibitor of microtubule assembly that induces microtubule disassembly in vitro.
||MAZ51 is a potent and selective inhibitor of vascular endothelial growth factor receptor (VEGFR)-3 (Flt-4) tyrosine kinase. MAZ51 induces cell rounding and G2/M cell cycle arrest in glioma cells through phosphorylation of Akt/GSK3β and activation of RhoA. MAZ51 inhibits the proliferation and induces the apoptosis of a variety of non-VEGFR-3-expressing tumor cell lines.
||MBCQ is a potent and selective cGMP-specific phosphodiesterase (PDE5) inhibitor with an IC50 of 19 nM.
||MBP146-78 is a potent and selective inhibitor of cyclic GMP(cGMP)-dependent protein kinases/Protein Kinase G (PKG) and displays cytostatic activity against Toxoplasma gondii.
||MBX-4132 is a member of oxadiazoles that inhibits trans translation by binding to the bacterial ribosome.
||MBX2329 is a specific inhibitor of HA-mediated viral entry that inhibits HPAI H5N1 virus strain and HA-mediated viral entry.
||MC-DOXHZN hydrochloride is an albumin-binding prodrug of Doxorubicin with acid-sensitive properties. Doxorubicin is a DNA topoisomerase II inhibitor.
||Mc-Val-Ala-PAB, a useful linker, makes antibody-drug-conjugate (ADC) for targeting drug delivery.
||MC-Val-Cit-PAB,also known as MC-Val-Cit-PAB-OH,is a cathepsin cleavable ADC peptide linker and is used for making ADC conjugate (antibody-drug conjugate).
||MC-Val-Cit-PAB-PNP (Mc-Val-Cit-PABC-PNP) is a cathepsin cleavable ADC peptide linker that is applicable to the synthesis of antibody-drug conjugates (ADCs).
||MC180295 ((rel)-MC180295) is a novel potent and selective CDK9 inhibitor with an IC50 of 5 nM and is at least 22-fold more selective for CDK9 over other CDKs.
||MCB-613 is a potent steroid receptor coactivator (SRC) stimulator.
||MCC7840 (Emlenoflast), a sulfonylurea, is a potent and selective inhibitor of NLRP3 inflammasome, with an IC50 of <100 nM.
||MCC950 (CP-456773, CRID3) is a potent and selective inhibitor of NLRP3 (NOD-like receptor (NLR) family, pyrin domain-containing protein 3) with IC50 of 7.5 nM and 8.1 nM in BMDMs and HMDMs, respectively.
||MCC950 Sodium (CP-456773 Sodium)
||MCC950 Sodium (CP-456773 Sodium, CRID3 sodium salt) is a potent, selective inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs; but not the AIM2, NLRC4 or NLRP1 inflammasomes.
||MCHr1 antagonist 2
||MCHr1 antagonist 2 is a melanin concentrating hormone receptor 1 antagonist with IC50 of 65 nM. MCHr1 antagonist 2 also inhibits hERG with IC50 of 4.0 nM in IMR-32 cells.
||MCP110 is an inhibitor of Ras/Raf-1 interaction. MCP110 disrupts the interaction of activated Ras with Raf and is potential for the treatment of human tumors.
||MCU-i4 is a negative modulator of the mitochondrial calcium uniporter (MCU) complex that directly binds a specific cleft in MICU1 and decreases mitochondrial Ca2+ influx.
||MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD value of 189 μM.
||MD2-TLR4-IN-1 (Compound 22m) is a potent inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4). MD2-TLR4-IN-1 (compound 22m) inhibits lipopolysaccharide (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 of 0.89 μM and 0.53 μM, respectively.
||Mdivi-1 (Mitochondrial division inhibitor 1) is a selective cell-permeable inhibitor of mitochondrial division DRP1 (dynamin-related GTPase) and mitochondrial division Dynamin I (Dnm1) with IC50 of 1-10 μM. Mdivi-1 attenuates mitophagy and enhances apoptosis.
||MDK-1088 (T.cruzi Inhibitor) is a Trypanosoma cruzi inhibitor.
||MDK35833 (Oct3/4-inducer-1) is a potent Oct3/4-inducer. MDK35833 can promote the expression and stabilization of Oct3/4 and enhance its transcriptional activity in diverse human somatic cells.
||MDK74978 (Multi-kinase inhibitor I)
||MDK74978 (Multi-kinase inhibitor I) is an inhibitor of Multi-kinase.
||MDL 100009 is the S-enantiomer of MDL 100151 and the opposite enantiomer of MDL 100907. MDL 100009 is a selective antagonist of 5-HT2A.
||MDL-28170 (Calpain Inhibitor III) is a potent and selective calpain inhibitor of calpain that penetrates the blood-brain barrier and inhibits brain cysteine protease activity after systemic administration. MDL-28170 is also an inhibitor of γ-secretase.
||MDR-652 is a potent and specific agonist of transient receptor potential vanilloid 1 (TRPV1) with Ki of 11.4 nM and 23.8 nM for hTRPV1 and rTRPV1, respectively. MDR-652 has excellent and dose-dependent analgesic activity.
||ME-344 directly targets the OXPHOS complex 1, a pathway involved in the production of ATP, in the mitochondria. Treatment of tumor cells with ME-344 as a single agent results in a rapid loss of ATP and cancer cell death.ME-344 results in inhibition of cell growth and viability in all the leukemia cell lines with IC50 values in the range of 70–260 nM.
||Mebendazole (Vermox, Telmin, Pantelmin, Mebenvet) is a synthetic benzimidazole derivate and anthelmintic agent. Mebendazole interferes with the reproduction and survival of helminths by inhibiting the formation of their cytoplasmic microtubules, thereby selectively and irreversibly blocking glucose uptake.
||Mebeverine (Duspatalin, Duspatal, Colofac), a 3-phenylethylamine derivative of methoxybenzamine, acts as a musculotropic antispasmodic agent.
||Mebhydrolin Napadisylate (Diazoline, Diazolin, Incidal, Omeril) is classified as an antihistamine drug classes used to treat allergies.
||Mebicar, a derivative of bicyclic bis-ureas, inhibits the orientation reaction in albino mice, potentiates the action of narcotic hypnotics, abolishes the conditioned reflex reaction of avoidance, displays central adrenolytic activity, interferes with the norepinephrine metabolism in the brain stem.
||Mebrofenin (SQ 26962) is a type of iminodiacetic acid (IDA) that is available as a ready to use the kit for radio-labeling with Technetium-99m (Tc-99m). Tc-99m Mebrofenin is used clinical for hepatobiliary scintigraphy.
||Mecarbinate (Dimecarbin) is a chemical intermediate of arbidol hydrochloride.
||Mechlorethamine is the prototype of alkylating agents, it works by binding to DNA, crosslinking two strands and preventing cell duplication.
||Meclizine (NSC 28728) is a histamine H1 receptor antagonist used to treat nausea and motion sickness, has anti-histamine, anti-muscarinic and anti-oxidative phosphorylation properties, also an agonist ligand for mCAR (constitutive androstane receptor) and an inverse agonist for hCAR.
||Meclofenamate Sodium is a dual COX-1/COX-2 inhibitor with IC50 of 40 nM and 50 nM, respectively, used in the treatment of joint, muscular pain, arthritis and dysmenorrhea. Meclofenamate Sodium is a non-selective gap-junction blocker and a highly selective inhibitor of fat mass and obesity-associated (FTO) enzyme inhibitor.
||Meclofenoxate (Centrophenoxine) HCl
||Meclofenoxate (Centrophenoxine) HCl is an anti-aging drug used to treat the symptoms of senile dementia and Alzheimer's disease, and also inhibits the activity of cholinephosphotransferase.
||Medetomidine is a selective α2-adrenoceptor agonist, with Ki of 1.08 nM, exhibts 1620-fold selectivity over α1-adrenoceptor.
||Medicagenic acid (Castanogenin), a bioactive triterpenoid pentacyclic glycoside isolated from Herniaria glabra L., has low xanthine oxidase, collagenase, elastase, and tyrosinase inhibitory activity.
||Medicine Food Homology Compound Library
||A unique collection of 486 medicine food homology compounds used for high throughput screening (HTS) and high content screening (HCS).
||Medroxyprogesterone (MP) is a synthetic pregnane steroid and a derivative of progesterone. It is a potent progesterone receptor agonist.
||Medroxyprogesterone acetate (NSC-26386)
||Medroxyprogesterone acetate (MPA, NSC-26386, Medroxyprogesterone 17-acetate, Farlutin) is a synthetic progestin and act as a potent progesterone receptor agonist, used to treat abnormal menstruation or irregular vaginal bleeding.
||Mefenamic Acid (CI 473, CN-35355) is a competitive inhibitor of COX-1 and COX-2.
||Mefloquine HCl is a blood schizonticide by inhibiting hemozoin formation, used as an antimalarial drug.
||Megestrol, a synthetic progestin, is approved for the treatment of anorexia, cachexia, or an unexplained significant weight loss in patients with an acquired immunodeficiency syndrome diagnosis. Megestrol acetate (Megace) is one of the first progestational agents to be evaluated for use in the hormonal therapy of advanced breast cancer.
||Megestrol acetate (BDH1298, SC10363) is a synthetic progestogen, used to treat breast cancer and loss of appetite.
||Meglumine is an amino sugar derived from sorbitol for THP-1 cells with IC50 of 22 μg/mL.
||MEISi-2 Dihydrochloride is a potent MEIS inhibitor (MEISi) that significantly inhibits MEIS-luciferase reporters in vitro.
||Meisoindigo (N-Methylisoindigotin, Methylisoindigotin, Dian III), a derivative of Indigo naturalis, is an active compound of a Chinese anti-leukemia medicine that has been effectively used in the treatment of chronic myelogenous leukemia (CML). In vitro cell line studies have shown that this agent might induce apoptosis and myeloid differentiation of acute myeloid leukemia (AML).
||Melamine (Cyanuramide, Cyanurotriamide) is a widely-used intermediate, mainly employed as a raw material for producing melamine resin and is a chemical most often found in plastic materials.
||Melanotan II is an analog of the peptide hormone alpha-melanocyte stimulating hormone (α-MSH).
||Melatonin (NSC 113928)
||Melatonin (NSC 113928, NSC 56423, N-Acetyl-5-methoxytryptamine) is a MT receptor agonist, used as a dietary supplement. Melatonin is a selective ATF-6 inhibitor and downregulates COX-2. Melatonin enhances mitophagy and regulates the homeostasis of apoptosis and autophagy.
||Melezitose, also spelled melicitose, is a nonreducing trisaccharide sugar that is produced by many plant sap eating insects.
||Melibiose (Galalpha1-6Glcbeta) is a nondigestible disaccharide that consists of one galactose and one glucose moiety in an alpha (1-6) glycosidic linkage.
||Melitracen hydrochloride (Thymeol) is a potential dopamine D1/2 receptor antagonist which has antidepressant properties.
||Melittin (MLT, Forapin, Forapine) is an activator of phospholipase A2 (PLA2) that stimulates the activity of the low molecular weight PLA2, while it does not the increase the activity of the high molecular weight enzyme.
||Melittoside, a natural compound, is the first iridoid to be found to contain two molecules of sugar (glucose).
||MELK-8a Dihydrochloride is a novel inhibitor of maternal embryonic leucine zipper kinase (MELK) with an IC50 of 2 nM.
||Meloxicam is a selective COX inhibitor, used to relieve pain and fever effects.
||Melphalan (Alkeran, Sarcolysin, L-PAM) is a phenylalanine derivative of nitrogen mustard with antineoplastic activity.
||Memantine HCl is an antagonist of NMDAR. It is also a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with IC50 of 1.12 μM and 242.4 μM, Ki of 0.51 μM and 84.4 μM, respectively.
||Menadiol Diacetate (Vitamin K4, Acetomenaphthone, Kapilin) is a synthetic hydrophilic menadione compound, which is clinically used as hemostasis medicine. It induces caspase-3-related apoptosis pathway via mitochondrial dysfunction and DNA fragmentation.
||Menadione (NSC 4170)
||Menadione (NSC 4170, Vitamin K3), a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement.
||Menadione bisulfite sodium
||Menadione(Vitamin K3) bisulfite sodium, a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement.
||Menbutone (Genabilin, Naftobil, Genabilic acid), or genabilic acid, is a derivative of oxybutyric acid which acts as a choleretic stimulating secretion, a trypsinogen and a pepsinogen.
||Menotropin (Human Menopausal Gonadotrophin) is a hormonally active medication for the treatment of fertility disturbances, which are extracted from the urine of postmenopausal women.
||Mentha Arvensis Leaf Extract
Menthone is one of the main volatile components of the essential oil of peppermint (Mentha piperita L.). Menthone is used as antioxidant agent and has a good compensatory effect with significant reduction in DNA damages in sperm cells.
||Mephenesin (Decontractyl, Cresoxydiol, Memphenesin, Mephedan) is centrally acting muscle relaxant, a topical analgesic and may be an NMDA receptor antagonist.
||Mepivacaine (Carbocaine) is a local anesthetic indicated for infiltration, nerve block, and epidural anesthesia.
||Mepivacaine is a tertiary amine used as a local anesthetic.
||Meprednisone (NSC 527579, SCH 4358) is a glucocorticoid and a methylated derivative of prednisone.
||Meptazinol is a unique centrally active opioid analgesic, which inhibits [3H]dihydromorphine binding with IC50 of 58 nM.
||Mequinol (4-Methoxyphenol) is a depigmentation agent.
||Mequitazine (LM-209) is a histamine H1 antagonist which competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract.
||Merafloxacin (CI-934) is a fluoroquinolone antibacterial thats inhibit -1 frameshifting efficiency of SARS-CoV-2 and other betacoronaviruses.
||Meranzin hydrate is an absorbed bioactive compound from the Traditional Chinese Medicine (TCM) Chaihu-Shugan-San (CSS) that possesses anti-depression and anti-atherosclerosis effects.
||Merbromin (Mercury dibromofluorescein disodium salt, Mercurochrome, Merbromine, Mercurocol, Sodium mercurescein, Asceptichrome, Supercrome, Brocasept, Cinfacromin), a xanthene dye, is a topical antiseptic used for minor cuts and scrapes. Merbromin is an organomercuric disodium salt compound and a fluorescein. Merbromin is a selective inhibitor of 3CLpro and provides a scaffold to design effective inhibitors of SARS-CoV-2.
||Mercaptopurine is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.
||Merestinib (LY2801653) is a type-II ATP competitive, slow-off inhibitor of Met (c-Met) tyrosine kinase with a dissociation constant (Ki) of 2 nM, a pharmacodynamic residence time (Koff) of 0.00132 min(-1) and t1/2 of 525 min. Merestinib (LY2801653) also inhibits MST1R, AXL, ROS1, MKNK1/2, FLT3, MERTK, DDR1 and DDR2 with IC50 of 11 nM, 2 nM, 23 nM, 7 nM, 7 nM, 10 nM, 0.1 nM and 7 nM, respectively.
||Mericitabine (RG 7128, R-7128, PSI 6130 diisobutyrate) is a nucleoside inhibitor of the HCV NS5B polymerase that acts as an RNA chain terminator and prevents elongation of RNA transcripts during replication.
||Merimepodib (Merimempodib, MMPD, VI-21,497, VX-497) is a potent, specific, and reversible inosine monophosphate dehydrogenase(IMPDH) inhibitor with antiviral activity against hepatitis C virus (HCV) and a variety of DNA and RNA viruses in vitro.Merimepodib is an immunosuppressive agent.
||Meropenem (SM 7338) is an ultra-broad spectrum injectable antibiotic.
||Meropenem is a broad-spectrum antibacterial agent of the carbapenem family with a broad spectrum of in vitro activity against Gram-positive and Gram-negative pathogens.
||Mertansine (DM1, Maytansinoid DM1), an antibody-conjugatable maytansinoid, is a selective microtubule inhibitor that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. Mertansine can be attached to a monoclonal antibody with a linker to create an antibody-drug conjugate (ADC). Solutions are best fresh-prepared.
||Mesaconitine, one of the aconite alkaloids in Aconiti tuber, increases the [Ca2+]i level in endothelial cells by influx of Ca2+ from extracellular spaces.
||Mesalamine (5-Aminosalicylic acid, 5-ASA, Mesalazine, Apriso, Asacol, Pentasa, Canasa) is a specific inhibitor of TNFα-induced IKK activity, used to treat inflammatory bowel disease.
||Mesembryanthemum spectabile Extract
||Mesna, a sulfhydryl compound that is used to reduce the incidence of hemorrhagic cystitis associated with certain chemotherapeutic agents.
||Mestranol is the 3-methyl ether of ethinyl estradiol, which is a potent estrogen receptor agonist and used as oral contraceptives.
MET kinase-IN-2 is a potent, selective, orally bioavailable inhibitor of MET kinase with IC50 of 7.4 nM. MET kinase-IN-2 has antitumor activity
||Metabolism Compound Library
||A unique collection of 2851 small molecules with biological activity in numerous metabolic pathway: glycometabolism, lipid metabolism, proteolysis, etc.
||Metadoxine (Metadoxil, Metasin, pyridoxine-pyrrolidone carboxylat), also known as pyridoxine-pyrrolidone carboxylate, is a drug used to treat chronic and acute alcohol intoxication. Metadoxine is a novel 5-HT2B receptor antagonist with a possible therapeutic role in treating ADHD.
||Metamizole sodium hydrate
||Metamizole (Dipyrone) sodium hydrate is a potent inhitior of cyclooxygenase (COX) with strong analgesic as well as antipyretic and spasmolytic properties.
||Metarrestin (ML246) is an orally active and specific perinucleolar compartment (PNC) inhibitor that disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription. Metarrestin blocks metastatic development and extends survival in mouse cancer models.
||Metaxalone (Skelaxin, Methaxalonum, Zorane) is a muscle relaxant used to relax muscles and relieve pain caused by strains, sprains, and other musculoskeletal conditions.
||Metformin (1,1-Dimethylbiguanide), a widely used drug for treatment of type 2 diabetes, activates AMP-activated protein kinase (AMPK) in hepatocytes. Metformin promotes mitophagy in mononuclear cells. Metformin induces apoptosis of lung cancer cells through activating JNK/p38 MAPK pathway and GADD153.
||Metformin HCl (1,1-Dimethylbiguanide HCl) decreases hyperglycemia in hepatocytes primarily by suppressing glucose production by the liver (hepatic gluconeogenesis). Metformin promotes mitophagy in mononuclear cells. Metformin induces apoptosis of lung cancer cells through activating JNK/p38 MAPK pathway and GADD153.
||Methacholine (Mecholyl, Acetyl-β-methylcholine) is a synthetic choline ester that acts as a non-selective muscarinic receptor agonist in the parasympathetic nervous system but has little effects on the nicotinic receptors.
||Methacycline HCl (Rondomycin) is a tetracycline antibiotic, and also an inhibitor of epithelial–mesenchymal transition (EMT) with IC50 of roughly 5 μM, used to treat various infections.
||Methandrostenolone (Dianabol, Metanabol, Methandienone, Methandrolone, Dehydromethyltestosterone, Perabol) is a synthetic steroid with anabolic properties that are more pronounced than its androgenic effects.
||Methasulfocarb is a fungicide, bactericide, and wood preservative.
||Methazolamide (CL 8490) is a carbonic anhydrase inhibitor with Ki of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively.
||Methenamine is an antibiotic used for the treatment of urinary tract infection.
||Methenamine Hippurate is the hippurate salt form of methenamine, a prodrug and inactive weak base that is hydrolyzed to formaldehyde in acid urine.Methenamine Hippurate is the component of Hiprex drug which has antibacterial activity.
||Methimazole (Tapazole, Thiamazole) is an antithyroid medicine.
||Methionine (MRX-1024, D-Methionine) is an activitor of GABAA receptor that modulates neuronal activity.
||Methocarbamol (AHR 85) is a carbonic anhydrase inhibitor, used as a central muscle relaxant to treat skeletal muscle spasms.
||Methoprene is a growth-regulating insecticide that manifests its toxicity to target organisms by acting as a juvenile hormone agonist.
||Methotrexate (CL14377, MTX, NCI-C04671, Amethopterin, WR19039, abitrexate), analog of folic acid, is a nonspecific inhibitor of the dihydrofolate reductase(DHFR) of bacteria and cancerous cells as well as normal cells. It forms an inactive ternary complex with DHFR and NADPH. Methotrexate (MTX) induces apoptosis.
||Methotrexate sodium, an inhibitor of tetrahydrofolate dehydrogenase, is an antineoplastic antimetabolite with immunosuppressant properties.
||Methoxsalen (Xanthotoxin, NCI-C55903) is a naturally occurring photoactive substance found in the seeds of the Ammi majus (Umbelliferae) plant, used in the diagnosis and treatment of psoriasis; A CYP2A5/6 inhibitor.
||Methoxyphenamine Hydrochloride (2-methoxy-N-methylamphetamine, OMMA) is a β-adrenergic receptor agonist of the amphetamine class used as a bronchodilator.
||Methscopolamine is a muscarinic acetylcholine receptor blocker.
||Methyclothiazide is a substituted benzothiadiazide, used to treat high blood pressure and fluid retention caused by various conditions including heart disease.
||Methyl 2,6-dichlorobenzoate (2,6-Dichlorobenzoic acid methyl ester) is a biochemical compound that is used for proteomics research.
Methyl 2-(methylamino)benzoate, a terpene found in Citrus reticulate Blanco leaves, has the potential for pain research.
||Methyl 3-aminopyrazine-2-carboxylate is used in chemical synthesis.
||Methyl 3-indolyacetate is a phytohormone.
||Methyl 4-aminobutyrate HCl
||Methyl 4-aminobutanoate (GABA methyl ester) is a methyl ester resulting from the formal condensation of gamma-aminobutyric acid with methanol.
||Methyl 4-hydroxybenzoate (Methylparaben, Methyl p-hydroxybenzoate, Nipagin) is an anti-fungal agent often used in a variety of cosmetics, personal-care products and food preservatives.
||Methyl 4-hydroxycinnamate (OMpCA) is a model chromophore of the Photoactive Yellow Protein (PYP).
Methyl acetylacetate (MAA, Acetoacetate methyl ester, Methyl 3-oxobutanoate, Methyl 3-oxobutyrate, Methyl acetoacetate, Methyl acetylacetate), an endogenous metabolite, is used as a chemical reagent used in the synthesis of pharmaceuticals.
||Methyl Aminolevulinate Hydrochloride
||Methyl Aminolevulinate (Aminolevulinic acid methyl ester Hydrochloride, Methyl 5-aminolevulinate Hydrochloride) is a prodrug that is metabolised to protoporphyrin IX used in photodynamic therapy.
Methyl caffeate, an antimicrobial agent, shows moderate antimicrobial and prominent antimycobacterial activities. Methyl caffeate also exhibits α-glucosidase inhibition activity, oxidative stress inhibiting activity, anti-platelet activity, antiproliferative activity in cervix adenocarcinoma and anticancer activity in lung and leukmia cell lines.
||Methyl Cholate (Cholic acid methyl ester) is methyl ester form of Cholic acid that is a primary bile acid mainly produced by the liver.
||Methyl cinnamate, an active component of Zanthoxylum armatum, is a widely used natural flavor compound with antimicrobial and tyrosinase inhibitor activities. Methyl Cinnamate Inhibits Adipocyte Differentiation via Activation of the CaMKK2--AMPK Pathway in 3T3-L1 Preadipocytes.
||Methyl cyclohexanecarboxylate (Hexahydrobenzoic acid methyl ester, Methyl hexahydrobenzoate) is a flavouring ingredient and is used as a material for chemical synthesis.
||Methyl dihydrojasmonate (Hedione, Kharismal) is a flavouring ingredien with the smell vaguely similar to jasmin.
||Methyl EudesMate (Methyl tri-O-methylgallate) is the methyl ester of 3,4.5-trimethoxybenzoic acid that used as an intermediate in the synthesis of pharmaceuticals.
||Methyl eugenol (4-allylveratrole, eugenyl methyl ether, O-methyleugenol), as a constituent in leaves, fruits, stems, and/or roots, is used as a flavoring agent, as a fragrance and as an anesthetic in rodents.
||Methyl furan-2-carboxylate (Methyl pyromucate, Methyl 2-furoate) is found in cocoa and cocoa products. It is used in food flavouring and preparation of sesquiterpene lactone.
||Methyl Gallate (Methylgallate, Gallic acid methyl ester, Gallicin) is a plant polyphenol with antioxidant, anticancer, and anti-inflammatory activities.
Methyl isoeugenol (Methylisoeugenol) is an eugenol analogue isoeugenol isolated from Acori Tatarinowii Rhizoma. Methyl isoeugenol is a highly attractive lure for Z. diversus and would be a valuable inclusion as an attractant in monitoring and male annihilation programs.
||Methyl linoleate (Linoleic acid methyl ester), found in cloves, is a fatty acid methyl ester of linoleic acid which is an essential fatty acid in mammalian nutrition and is used in the biosynthesis of prostaglandins and cell membranes.
||Methyl linolenate (Linolenic acid methyl ester, Methyl alpha-linolenate) is a fatty acid methyl ester derived from alpha-linolenic acid and acts as a plant metabolite and an insect attractant.
||Methyl methanesulfonate (MMS), a DNA alkylating agent, modifies both guanine (to 7-methylguanine) and adenine (to 3-methlyladenine) to cause base mispairing and replication blocks, respectively.
||Methyl nicotinate (methyl pyridine-3-carboxylate) is an ester of methyl alcohol and nicotinic acid. It is a rubefacient.
||Methyl nonadecanoate (Nonadecanoic Acid methyl ester) is a fatty acid methyl ester, which is less water soluble but more amenable for the formulation of nonadecanoate-containing diets and dietary supplements.
||Methyl Oleate (oleic acid methyl ester, Methyl cis-9-Octadecenoate) is a methyl ester of oleic acid, which is a monounsaturated fatty acid and is one of the major components of membrane phospholipids.
||Methyl palmitate (Methyl hexadecanoate, Palmitic acid methyl ester), a kind of fatty acid methyl ester, could be found in many plants and possesses acaricidal activity.
||Methyl protocatechuate (Methyl 3,4-dihydroxybenzoate, 3,4-Dihydroxybenzoic acid methyl ester, Protocatechuic Acid Methyl Ester) is also known as Protocatechuic Acid Methyl Ester. Protocatechuic Acid, a dihydroxybenzoic acid, is a major metabolite of antioxidant polyphenols found in green tea with antioxidant and anti-inflammatory effects.
||Methyl rosmarinate is a natural product separated from Rabdosia serra, with a powerful inhibiting effect on tyrosinase.
||Methyl salicylate (Betula oil, Gaultheria oil, Methyl 2-hydroxybenzoate, Natural wintergreen oil) is an organic ester naturally produced by many species of plants, particularly wintergreens. It is an agonist for TRPA1 and TRPV1.
||Methyl Stearate (Methyl Octadecanoate, Stearic Acid methyl ester), found in cloves, is an antifoaming agent and fermentation nutrient.
||Methyl syringate (Syringic Acid Methyl Ester), a plant phenolic compound, is a specific and selective TRPA1 agonist.
||Methyl Vanillate, one of the ingredients in Hovenia dulcis Thunb, activates the Wnt/β-catenin pathway and induces osteoblast differentiation in vitro.
||Methyl α-D-mannopyranoside can be used as an intermediate for chemical sythesis and is a competitor inhibitor of the binding of mannose by Escherichia coli.
Methyl β-D-Galactopyranoside (Methyl beta-D-galactoside, Methylgalactoside) is an endogenous metabolite.
||Methyl Hesperidin is a flavanone glycoside (flavonoid) (C28H34O15) found abundantly in citrus fruits. Its aglycone form is called hesperetin.
||Methyl-β-cyclodextrin (MβCD, Methyl-beta-cyclodextrin, M-β-CyD, Methyl-β-CD) is a cholesterol-removing agent mainly used for lipid raft disruption. Methyl-β-cyclodextrin induces caspase-dependent apoptosis in PEL cells and inhibits the growth and invasion of PEL cells without apparent adverse effects, suggesting the potential effective antitumor activities.
||Methylamine is used as a building block for the synthesis of many other commercially available compounds.
||Methylation Compound Library
||A unique collection of 112 compounds used for researching the function of methylation in epigenetics,cancer,embryogenesis,etc.
||Methylbenactyzine Bromide (Gastrimade, Noinarin, Paragone, Semulgin) is a kind of muscarinic cholinergic receptor antagonist with antispasmodic activity.
||Methylcobalamin (Mecobalamin, Vancomin, Methycobal, Cobametin) is one active form of vitamin B12 which can directly participate in homocysteine metabolism. It is used to treat some nutritional diseases and other diseases in clinic, such as Alzheimer's disease and rheumatoid arthritis.
||Methyldopa (Aldomet) is a DOPA decarboxylase competitive inhibitor with an ED50 of 21.8 mg/kg.
||Methylene Blue (Basic Blue 9, Tetramethylthionine chloride, methylthioninium chloride, CI-52015) is used as a dye in chromoendoscopy. It Inhibits tau filament formation with IC50 of 1.9μM. Also it inhibits soluble guanylyl cyclase.
||Methylguanidine is a guanidine compound deriving from protein catabolism.
||Methyllycaconitine citrate is a specific antagonist of α7 neuronal nicotinic acetylcholine receptor (α7nAChR).
||Methylmalonate (Methylmalonic acid, Isosuccinic Acid, NSC 25201, MMA) is a dicarboxylic acid that can be derived from methylmalonyl-coenzyme A (methylmalonyl-CoA).
||Methylnissolin, isolated from Astragalus membranaceus, inhibits platelet-derived growth factor (PDGF)-BB-induced cell proliferation and phosphorylation of extracellular signal-regulated kinase 1/2 (ERIC1/2) mitogen-activated protein (MAP) kinase.
||Methylnonylketone (2-Undecanone, IBI-246), also known as 2-Undecanone and IBI-246, is a natural non-toxic insect repellant compound.
Methylophiopogonanone A (MOA), a homoisoflavonoid extracted from Ophiopogon japonicus, attenuates myocardial apoptosis and improves cerebral ischemia/reperfusion injury. Methylophiopogonanone A also shows strong ability to ameliorate the hyperlipidemia in HFD-induced rats.
Methylophiopogonanone B, a homoisoflavonoid extracted from the root of Ophiopogon japonicas, shows high antioxidant ability.
||Methylophiopogonone A, a homoisoflavonoid isolated from the tuberous roots of Ophiopogon japonicas, shows anti-inflammatory activity.
||Methyloxalacetic acid diethyl ester
||Methyloxalacetic acid diethyl ester (Diethyl 2-methyl-3-oxosuccinate, Diethyl methyloxobutanedioate, Diethyl oxalpropionate) is a member of the class of compounds known as beta-keto acids and derivatives.
||Methylprednisolone (NSC-19987) is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis.
||Methylprednisolone (NSC-19987, Medrol) acetate is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis.
||Methylprednisolone sodium succinate is a glucocorticoid used to treat a variety health issues including severe allergic reactions, asthma, autoimmune diseases, blood disorders, gastrointestinal diseases and endocrine disorders.
||Methylprednisolone sodium succinate
||Methylprednisolone sodium succinate (U-9088, 6α-Methylprednisolone 21-hemisuccinate Sodium) is a corticosteroid medication that reduces inflammation.
||Methyl protodioscin, a bioactive natural compound isolated from Dioscorea collettii Makino (Dioscoreaceae), has numerous pharmacological activities, including anti-inflammation, lipid-lowering, and
Methylsticin is a kavalactone isolated from the kava roots. Methylsticin exhibit osteoclast formation inhibitory activity.
||Methylthiouracil (NSC-193526, NSC-9378) is an antithyroid agent. Methylthiouracil suppresses the production TNF-α and IL-6, and the activation of NF-κB and ERK1/2.
||Meticrane is a diuretic that inhibits the reabsorption of sodium and chloride ions in the distal convoluted tubule. Meticrane is used to treat essential hypertension.
||Metipranolol (Betamann) is potent β-adrenergic receptor antagonist, possessing the beta-blocking potencies (pA2) of 8.3, 8.4 at guinea pig atrial β1-adrenoceptor and β2-adrenoceptor of the rat uterus, respectively, also is a potent displacer of 3H-DHA binding, ligand concentration 0.7 nM, possessing a Ki value of 39 ± 24 nM.
||Metoclopramide is a dopamine antagonist used for the treatment of nausea and vomiting.
||Metoclopramide HCl is a selective dopamine D2 receptor antagonist, used for the treatment of nausea and vomiting.
||Metoclopramide hydrochloride hydrate
||Metoclopramide hydrochloride (Clorpa, Gimoti, Maxolon, Reglan) hydrate is primarily a Dopamine receptor antagonist, with 5HT3 receptor antagonist and 5HT4 receptor agonist activity, and used as an antiemetic and gastroprokinetic.
||Metolazone (SR 720-22) is a diuretic that primarily used to treat congestive heart failure and high blood pressure.
||Metoprine (BW 197U), a diaminopyrimidine derivative, is a potent inhibitor of histamine N-methyltransferase (HMT) that crosses the blood-brain barrier and increases brain histamine levels. Metoprine is an antifolate and antitumor agent.
||Metoprolol is a cardioselective β1-adrenergic blocking agent with log Kd values of −7.26±0.07, −6.89±0.09, −5.16±0.12 for β1, β2, and β3 adrenoceptors, respectively. It is used for acute myocardial infarction, heart failure, angina pectoris and mild to moderate hypertension.
||Metoprolol Tartrate (CGP 2175E) is a selective β1 receptor blocker medication, used to treat hypertension and heart failure.
||Metrizoic acid is a diagnostic radiopaque. The mechanism of action of metrizoic acid is as a X-Ray contrast activity.
||Metronidazole, a synthetic antibacterial and antiprotozoal agent of the nitroimidazole class, is used against protozoa.
||Metronidazole Benzoate (Benzoyl metronidazole) is the benzoate ester of metronidazole, a synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities.
||Metroprolol Succinate (Metoprolol succinate) is the succinate salt form of metoprolol, a cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic activity.
||Metyrapone (NSC-25265, SU-4885) is an inhibitor of the enzyme steroid 11-beta-monooxygenase (CYP11B1) that inhibits adrenal steroid synthesis.
||Metyrosine (α-Methyltyrosine), an antihypertensive drug, is a tyrosine hydroxylase inhibitor.
||Mevastatin (ML-236B) is a competitive inhibitor of HMG-Coenzyme A (HMG-CoA) reductase with a binding affinity 10,000 times greater than the HMG-CoA substrate itself.
||Mexenone (Benzophenone-10) is a benzophenone-derived sunscreening agent.
||Mexiletine HCl (KO1173) belongs to Class IB anti-arrhythmic group of medicines, inhibits sodium channels to reduce the inward sodium current.
||Mezigdomide (CC-92480) is a novel protein degrader and a cereblon E3 ligase modulator (CELMoD) that has anti-myeloma activity.
||Mezlocillin sodium is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms.
||MF-094, a potent and selective USP30 inhibitor (IC50=0.12 μM), accelerates diabetic wound healing by inhibiting the NLRP3 inflammasome.
||MF-438 is a potent and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor with IC50 of 2.3 nM for rSCD1.
MF-766 is a highly potent, selective and orally active EP4 antagonist with a Ki of 0.23 nM. MF-766 behaves as a full antagonist with an IC50 of 1.4 nM (shifted to 1.8 nM in the presence of 10% HS) in the functional assay. MF-766 can be used for cancer and inflammation diseases research.
||MG-101 (ALLN, Calpain inhibitor-1, Ac-LLnL-CHO) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins.
||MG132 (Z-Leu-Leu-Leu-al) is a potent cell-permeable proteasome and calpain inhibitor with IC50s of 0.1 μM and 1.2 μM for the inhibition of proteasome and calpain, respectively. MG132 activates autophagy and induces apoptosis in tumor cells.
||MG149 (Tip60 HAT inhibitor) is a potent histone acetyltransferase inhibitor with IC50 of 74 μM and 47 μM for Tip60 and MOF,respectively.
||MGCD-265 is a potent, multi-target and ATP-competitive inhibitor of c-Met and VEGFR1/2/3 with IC50 of 1 nM, 3 nM/3 nM/4 nM, respectively; also inhibits Ron and Tie2. Phase 1/2.
||MGH-CP1 is a potent and selective inhibitor of transcriptional enhanced associate domain (TEAD) palmitoylation. MGH-CP1 exhibits dose-dependent and potent inhibition of TEAD2/4 auto-palmitoylation in vitro with IC50 of 710 nM and 672 nM, respectively.
||MHY1485 is a potent, and cell-permeable mTOR activator, and also potently inhibits autophagy.
||MI-136 can specifically inhibit the menin-MLL interaction. It inhibits DHT-induced expression of androgen receptor (AR) target genes.
||MI-2 (Menin-MLL Inhibitor)
||MI-2 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM.
||MI-463 is a potent inhibitor of Menin-MLL interaction with an IC50 value of 15.3 nM.
||MI-503 is a potent and selective Menin-MLL inhibitor with IC50 of 14.7 nM. It shows pronounced growth suppressive activity in a panel of human MLL leukemia cell lines(GI50 at 250 nM-570 nM range), but only a minimal effect in human leukemia cell lines without MLL translocations.
||MI-773 (SAR405838) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1.
||Mianserin (ORG GB-94) is an potent antagonist of H1 histamine receptor and 5-HT serotonin receptors, used for the treatment of depression.
||Micafungin (FK 463) Sodium
||Micafungin Sodium (FK463, Mycamine) is an inhibitor of 1, 3-beta-D-glucan synthesis, used as an antifungal drug.
||Miconazole (Monistat) is an imidazole antifungal agent.
||Miconazole (NSC 169434) Nitrate is an imidazole antifungal agent by inhibiting ergosterol biosynthesis and inducing ROS, used to treat vaginal yeast infections.
||MID-1 is a disruptor of MG53-IRS-1 (Mitsugumin 53-insulin receptor substrate-1) interaction, which can disrupts molecular association of MG53 with IRS-1 and abolishes MG53-induced IRS-1 ubiquitination and degradation in skeletal muscle, leading to elevated IRS-1 expression level and increased insulin signaling and glucose uptake.
||Midecamycin (Espinomycin A, Medecamycin A1, Platenomycin B1, Rubimycin, Turimycin P3) is a naturally occuring macrolide antibiotic that acts by inhibiting bacterial protein synthesis.
||Midodrine belongs to the class of medications known as vasopressors. It is an adrenergic alpha-1 agonist.
||Midodrine hydrochloride is the hydrochloride salt form of midodrine, an adrenergic alpha-1 agonist used as a vasopressor.
||Midostaurin (pkc412, CGP 41251) is a multi-targeted kinase inhibitor, including PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50 ranging from 80-500 nM.
||Mifepristone (RU486, C-1073, RU 38486, Mifegyne) is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively. Mifepristone promotes cell autophagy and apoptosis, decreases Bcl-2 level and increases Beclin1 level, accompanied by weakened interaction between Bcl-2 and Beclin1.
||Mifobate (SR-202), a potent and specific PPARγ antagonist, selectively inhibits Thiazolidinedione (TZD)-induced PPARγ transcriptional activity (IC50=140 μM).
||Miglitol (BAY-M-1099) is an oral anti-diabetic drug.
Miglustat (Zavesca, N‐butyldeoxynojirimycin, OGT 918) is an orally administered ceramide glucosyltransferase inhibitor which prevents the lysosomal accumulation of glucocerebroside.
||Milbemycin Oxime is a broad spectrum anti-parasitic drug that is active against worms (anthelmintic) and mites (miticide).
||Milciclib (PHA-848125) is a potent, ATP-competitive CDK inhibitor for CDK2 with IC50 of 45 nM. It is >3-fold more selective for CDK2 than CDK1, 2, 4, 5, and 7. Milciclib (PHA-848125) induces cell death through autophagy. Phase 2.
||Mildronate (Meldonium, MET-88, Quaterin) is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorption.
||Militarine is a major chemical constituent of the tuber of Bletilla striata (Thunb.) Reichb.f., with a prominent neuroprotective effect.
||Milk thistle Extract
||Millet Extracts Extract
||Milnacipran inhibits both norepinephrine transporter (NET) and norepinephrine transporter (SERT) with IC50 of 77 nM and 420 nM, respectively.
||Milrinone (Win 47203) is a phosphodiesterase 3 (PDE3) inhibitor, used to increase the heart's contractility.
||Miltefosine (Hexadecylphosphocholine) inhibits PI3K/Akt activity with ED50 of 17.2 μM and 8.1 μM in carcinoma cell lines A431 and HeLa, first oral drug for Visceral leishmaniasis, effective against both promastigotes and amastigotes.
Miltirone is a natural compound isolated from the roots of Salvia miltiorrhiza, which is a central benzodiazepine receptor partial agonist.
||Mimosa Pudica Extract
||Mimosa Pudica Root Extract
||MINA53 inhibitor (Compound 10)
MINA53 inhibitor (Compound 10, 2-((3-Phenylpropyl)thio)-3,4-dihydro-4-oxopyrimidine-5-carboxylic Acid) is a first-in-class inhibitor of the ribosomal oxygenase MINA53 with an IC50 of 1.5 μM in vitro.
||Minaprine dihydrochloride is hydrochloride salt form of Minaprine, which acts as a reversible inhibitor of MAO-A in rats and weakly inhibit acetylcholinesterase in rat brain (striatum) homogenates.
||Minocycline (CL 59806) HCl
||Minocycline (CL 59806) HCl is the most lipid soluble and most active tetracycline antibiotic, binds to the 30S ribosomal subunit, preventing the binding of tRNA to the mRNA-ribosome complex and interfering with protein synthesis.
||Minodronic acid (YM529, ONO-5920) is a third-generation nitrogen-cotaining bisphosphonate that is used for the treatment of osteoporosis. Minodronic acid is an aminobisphosphonate that is a selective antagonist of purinergic P2X2/3 receptors involved in pain.
||Minoxidil (U-10858) is a vasodilator medication known for its ability to slow or stop hair loss and promote hair regrowth. Minoxidil is an ATP-sensitive potassium (KATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth.
||Minoxidil (U-58838) is a potent direct-acting peripheral vasodilator that reduces peripheral resistance and produces a fall in blood pressure.
MIPS521 is a positive allosteric modulator of the A1R that exhibits analgesic efficacy in rats in vivo.
||Mirabegron (YM 178) is a selective β3-adrenoceptor agonist with EC50 of 22.4 nM.
||Miransertib (ARQ 092) HCl
||Miransertib (ARQ 092) HCl is a novel, orally bioavailable and selective AKT pathway inhibitor exhibiting a manageable safety profile among patients with advanced solid tumors.
||Miransertib (ARQ-092) is a potent, selective and orally bioavailable allosteric inhibitor of Akt with IC50s of 2.7 nM, 14 nM and 8.1 nM for Akt1, Akt2, Akt3, respectively.
||Mirdametinib (PD0325901) is a selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM in cell-free assays, roughly 500-fold more potent than CI-1040 on phosphorylation of ERK1 and ERK2. Phase 2.
||Miridesap (CPHPC, Ro63-8695, GSK2315698) is a ligand for serum amyloid P component (SAP) and intends to inhibit and dissociate SAP binding to amyloid fibrils and tangles.
||Mirificin (Puerarin apioside)
Mirificin (Puerarin apioside) is an isoflavone in Puerariae Lobatae Radix. Mirificin inhibits tyrosinase (TYR) with an IC50 of 12.66 μM.
||Mirin is a potent Mre11–Rad50–Nbs1 (MRN) complex inhibitor, and inhibits Mre11-associated exonuclease activity. Mirin inhibits MRN-dependent activation of ATM.
||Miriplatin (SM-11355) is a derivative of cisplatin containing myristates as a carrier ligand. It is a novel lipophilic platinum complex developed to treat hepatocellular carcinoma.
||Mirodenafil Dihydrochloride(SK-3530 dihydrochloride) is an oral phosphodiesterase type 5 (PDE-5) inhibitor used to treat erectile dysfunction (ED).
||Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand that has been used in trials studying the treatment of Post-herpetic Neuralgia, Pain Associated With Fibromyalgia, and Diabetic peripheral neuropathic pain.
||Mirtazapine (Org3770) is an adrenergic and seroton receptor antagonist, used to treat depression.
||Misoprostol(SC29333) is a synthetic prostaglandin E1 (PGE1) analog that is used to prevent gastric ulcers, to treat missed miscarriage, to induce labor, and to induce abortion.
||Mitapivat (AG-348) is an activator of a pyruvate kinase PKM2, an enzyme involved in glycolysis.
||Mitiglinide Calcium (KAD-1229) is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K+ channels in pancreatic beta-cells.
MiTMAB is a selective dynamin inhibitor that targets the dynamin-phospholipid interaction. MiTMAB inhibits dynamin GTPase activity with a Ki of 940 nM.
||Mito-TEMPO (MT), a mitochondria-targeted superoxide dismutase mimetic, protects against the early phase of acetaminophen (APAP) hepatotoxicity by inhibiting peroxynitrite formation. Mito-TEMPO treatment inhibits APAP-induced RIP3 kinase expression.
||Mitochondrial Fusion Promoter M1
||Mitochondrial fusion promoter M1 is a mitochondrial dynamic modulator that increases the expression of mitofusin 2, a mitochondrial outer membrane fusion protein, reduces brain mitochondrial dysfunction. Mitochondrial fusion promoter M1 alleviates brain damage in rats with cardiac ischemia/reperfusion injury.
||Mitochonic acid 5
||Mitochonic acid 5 (MA-5) reduces mitochondrial apoptosis via upregulation of mitophagy. Mitochonic acid 5 regulates mitophagy via Bnip3 through the MAPK-ERK-Yap signaling pathway. Mitochonic acid 5 modulates mitochondrial ATP synthesis.
||Mitomycin C (Ametycine) is an antineoplastic antibiotic by inhibiting DNA synthesis, used to treat different cancers. Mitomycin C induces apoptosis in a caspases-dependent and Fas/CD95-independent manner.
||Mitonafide inhibits the activity of Mycobacterium tuberculosis NAD+ dependent DNA ligase A at concentrations of 50 µM.
||Mitoquinone (MitoQ10) mesylate
||Mitoquinone mesylate (MitoQ, MitoQ10, Mitoubiquinone) is a TPP-based, mitochondria-targeted antioxidant that blocks H2O2-induced intracellular ROS responses and protects against oxidative damage. This product is a waxy solid.
||Mitotane (NCI-C04933), is an antineoplastic medication used in the treatment of adrenocortical carcinoma.
||Mitoxantrone (NSC-301739) 2HCl
||Mitoxantrone 2HCl (NSC-301739) is a dihydrochloride salt of Mitoxantrone. Mitoxantrone is an inhibitor of type II topoisomerase and protein kinase C (PKC) with IC50 of 8.5 μM for PKC. Mitoxantrone inhibits cell proliferative growth of MCF-7/wt cells with IC50 of 0.42 μM. Mitoxantrone also induces apoptosis.
Mitraphylline is the major pentacyclic oxindolic alkaloid presented in Uncaria tomentosa. Mitraphylline inhibits lipopolysaccharide-mediated activation of primary human neutrophils.
||Mivacurium chloride is a rapid, non-depolarising, neuromuscular blocking agent of short duration, used therefore as anesthetic, to provide skeletal muscle relaxation in minor surgical operations, in emergency surgical procedures of short to intermediate duration and during intubation of the trachea.
||Mivebresib (ABBV-075) is a novel BET family bromodomain inhibitor. It binds bromodomains of BRD2/4/T with similar affinities (Ki of 1-2.2 nM) and highly selective for 18 bromodomain proteins tested (Kd > 1 μM; more than 600-fold selectivity vs. BRD4), but exhibits roughly 10-fold weaker potency towards BRD3 (Ki of 12.2 nM) and has moderate activity towards CREBBP (Kd = 87 μM; 54-fold selectivity vs. BRD4). Mivebresib(ABBV-075) efficiently triggers apoptosis in various tumor cell.
||Mizagliflozin (KWA 0711)
||Mizagliflozin (KWA 0711) is a novel, potent, selective sodium glucose co-transporter 1 (SGLT1) inhibitor with Ki of 27 nM for human SGLT1. The selectivity ratio (Ki value for human SGLT2/Ki value for human SGLT1) of mizagliflozin is 303. Mizagliflozin shows the potential use for the amelioration of chronic constipation.
||Mizolastine (SL 850324) is a histamine H1-receptor antagonist with IC50 of 47 nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions.
||Mizoribine (Bredinin, NSC 289637) is an imidazole nucleoside and an immunosuppressant that inhibits HCV RNA replication with IC50 of ~ 100 μM for anti-HCV activity. Mizoribine is a selective inhibitor of inosine-5'-monophosphate dehydrogenase (IMPDH) and guanosine monophosphate synthetase. Mizoribine also inhibits SARS-CoV.
||MK-0752 is a moderately potent γ-secretase inhibitor, which reduces Aβ40 production with IC50 of 5 nM. Phase 1/2.
||MK-2048 is a potent inhibitor of integrase (IN) and INR263K with IC50 of 2.6 nM and 1.5 nM, respectively.
||MK-212 hydrochloride (HCl) is an agonist of 5HT2C-receptor.
||MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM in cell-free assays, respectively; no inhibitory activities against 250 other protein kinases observed. MK-2206 2HCl induces autophagy and apoptosis in cancer cells. Phase 2.
||MK-2461 is a potent, multi-targeted inhibitor for c-Met(WT/mutants) with IC50 of 0.4-2.5 nM, less potent to Ron, Flt1; 8- to 30-fold greater selectivity of c-Met targets versus FGFR1, FGFR2, FGFR3, PDGFRβ, KDR, Flt3, Flt4, TrkA, and TrkB. Phase 1/2.
||MK-4101, a potent inhibitor of the Hedgehog pathway, shows anti-tumor activity through the inhibition of proliferation and induction of extensive apoptosis in tumor cells.
||MK-5108 (VX-689) is a highly selective Aurora A inhibitor with IC50 of 0.064 nM in a cell-free assay and is 220- and 190-fold more selective for Aurora A than Aurora B/C, while it inhibits TrkA with less than 100-fold selectivity. MK-5108 (VX-689) induces autophagy. Phase 1.
||MK-571 sodium salt
||MK-571 sodium salt (L-660711) is a selective, orally active antagonist of leukotriene D4 receptor with Ki of 0.22 nM and 2.1 nM in guinea pig and human lung membranes, respectively.
||MK-8245 is an liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy. Phase 2.
||MK-8353 (SCH900353) is an orally bioavailable, selective, and potent ERK inhibitor that inhibits activated ERK1 and ERK2 in vitro, with IC50 values of 23.0 nM and 8.8 nM, respectively (IMAP kinase assay), and nonactivated ERK2, with an IC50 of 0.5 nM (MEK1-ERK2-coupled assay).
||MK-8719 is a selective and potent small molecule inhibitor of the O-GlcNAcase (OGA) enzyme with ki of 7.9nM for hOGA.
MK-8722 is a potent, direct, allosteric activator of all 12 mammalian pan-AMPK complexes.
||MK-8776 (SCH 900776)
||MK-8776 (SCH 900776) is a selective Chk1 inhibitor with IC50 of 3 nM in a cell-free assay. It shows 500-fold selectivity against Chk2. Phase 2.
||MK-886 is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP). It is also a moderately potent PPARα antagonist.
MK-0557 is a highly selective, orally available neuropeptide Y5 receptor antagonist with a ki of 1.6 nM.
||MK1064 is a selective orexin 2 receptor antagonist (2-SORA) with an IC50 of 18 nM.
||MK2 Inhibitor III
||MK2 Inhibitor III (MK2-IN-3) is an ATP-competitive MK2 (MAPKAP-K2) inhibitor with an IC50 value of 8.5 nM.
||MK2-IN-1 hydrochloride is a potent and selective MAPKAP-K2 (MK2) inhibitor with IC50 of 0.11 μM with a non-ATP competitive binding mode.
||MK571 (L660711) is a selective, orally active CysLT1 receptor(Cysteinyl leukotriene receptor) antagonist.
||MK6-83 is a novel Transient receptor potential melastatin member 1 (TRPML1) activator that may be used as a potential pharmacological treatment option for a specific subgroup of MLIV patients.
||MKC3946 is a potent and soluble IRE1α endoribonuclease domain inhibitor which triggered modest growth inhibition in multiple myeloma cell lines, without toxicity in normal mononuclear cells.
||MKC8866 (IRE1-IN-8866), a salicylaldehyde analog, is a specific IRE1α RNase inhibitor with IC50 of 0.29 μM for human IRE1α in vitro.
||MKT-077 (FJ-776) is a newly synthesized, highly water-soluble rhodacyanine dye that exhibits significant antitumor activity in a variety of model systems.
||ML-210 (CID 49766530) is a selective covalent inhibitor of cellular glutathione peroxidase 4 (GPX4) with EC50 of 0.04 μM and induces ferroptosis. ML-210 can selectively kill cells induced to express mutant RAS. ML-210 exhibits anti-cancer activity.
||ML-098 is an activator of the GTP-binding protein Rab7 with an EC50 of 77.62 nM.
||ML-18 is an antagonist of non-peptide bombesin receptor subtype-3 (BRS-3) with IC50 of 4.8 μM.
||ML-180 (SR1848) is a potent inverse agonist of orphan nuclear receptor NR5A2 (Liver receptor homologue-1, LRH1) with IC50 of 3.7 μM. ML-180 has the potential for LRH-1-dependent cancers.
||ML-297 (VU 0456810, CID 56642816) is a potent and selective activator of Kir3.1/3.2 (G protein-coupled inwardly rectifying potassium, GIRK1/2) channel with EC50 of 0.16 μM and 1.8 μM for GIRK1/2 and GIRK1/4, respectively. ML-297 is potential for the treatment of epilepsy.
||ML335 (CYM 51010, CID-23723457) is an agonist for OPRM1(μ-opioid receptor)-OPRD1(δ-opioid receptor) heterodimerization with EC50 of 403 nM demonstrating selectivity over the individual OPRM1 and OPRD1 receptors and the serotonin HT5A receptor with EC50 of 14.9 μM, 1.1 μM, and >40 μM, respectively.
||ML-7 is an inhibitor of smooth muscle myosin light chain kinase (MLCK) with a Ki value of 0.3 µM and displays reversible, ATP-competitive inhibition of Ca2+-calmodulin-dependent and -independent smooth muscle MLCKs. ML-7 also inhibits PKA and PKC with Ki of 21 μM and 42 μM, respectively.
||ML-9 HCl (ML-9 hydrochloride) is a selective and potent inhibitor of Akt kinase, myosin light chain kinase (MLCK) and stromal interaction molecule 1 (STIM1). ML-9 HCl is also a potent inhibitor of Ca2+-permeable channels. ML-9 HCl is a lysosomotropic agent targeting autophagy and cell death.
ML-SA1 (Mucolipin synthetic agonist 1) is an activator of TRPML channels. ML-SA1 also inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 values of ML-SA1 against DENV2 RNA and ZIKV RNA are 8.93 μM and 52.99 μM, respectively. ML-SA1 induces autophagy. ML-SA1 can be used for the research of broad-spectrum antiviral.
ML-SI3 is a potent TRPML channel inhibitor with IC50s of 4.7 µM and 1.7 µM for TRPML1 and TRPML2, respectively.
ML008 (NCGC00092410) is a potent and selective glucocerebrosidase inhibitor with IC50 of 31 nM.
||ML095 (MLS-0315848, CID-25067483) hydrochloride is a specific inhibitor of placental alkaline phosphatase. ML095 inhibits PLAP, TNAP and IAP with IC50 of 2.1, >100 and 53 μM, respectively.
||ML130 (Nodinitib-1) is a potent and selective inhibitor of NOD1 with IC50 of 0.56 μM, inhibits NF-κB activation, exhibits 36-fold selectivity over NOD2.
||ML141 (CID-2950007) is demonstrated to be a potent, selective and reversible non-competitive inhibitor of Cdc42 GTPase suitable for in vitro assays, with IC50 of 200 nM and selectivity against other members of the Rho family of GTPases (Rac1, Rab2, Rab7). ML141 is associated with an increase in p38 activation and may induce p38-dependent apoptosis/senescence. ML141 also protects neuroblastoma cells from metformin-induced apoptosis.
||ML161 (Parmodulin 2)
||ML161 (Parmodulin 2) is an allosteric inhibitor of PAR1 with IC50 of 0.26 μM.
||ML162 is a covalent inhibitor of cellular phospholipid glutathione peroxidase (GPX-4) that induces ferroptosis.
||ML167 (CID 44968231) is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor with IC50 of 136 nM, >10-fold selectivity for closely related kinases Clk1-3 and Dyrk1A/1B.
||ML188 is a non-covalent SARS-CoV 3CLpro inhibitor with IC50 of 1.5 μM. ML188 has antiviral activity.
||ML191 (CCG-152883, CID-23612552) is an antagonist of GPR55 with EC50 of 1.076 µM in U2OS cells overexpressing GPR55. ML-191 inhibits LPI-induced phosphorylation of ERK1/2 with IC50 of 328 nM.
||ML198 is a novel activator of glucocerebrosidase (GCase) and does not inhibit the enzyme's action, but can facilitate its translocation to the lysosome.
||ML204 is a novel, potent, and selective TRPC4 channel inhibitor with apparent IC50 values of about 1 μM in fluorescent intracellular Ca2+ assays and about 3 μM in whole-cell voltage clamp experiments. It exhibits some selectivity within the TRPC subfamily of channels and higher selectivity against other TRP channels and non-TRP channels.
||ML213 (CID-3111211) is a selective KCNQ2 (Kv7.2) and KCNQ4 (Kv7.4) potassium channel opener with EC50 of 230 nM and 510 nM, respectively.
||ML216 (CID-49852229) is a potent and selective inhibitor of the DNA unwinding activity of BLM(Bloom’s syndrome protein) with antitumor activity. ML216 inhibits helicases with IC50 of 0.97 μM and 2.98 μM for BLM636-1298 and BLMfull-length, respectively.
||ML221 is a potent apelin receptor (APJ) functional antagonist in cell-based assays that is >37-fold selective over the closely related angiotensin II type 1 (AT1) receptor. The IC50 values of ML221 are 0.70 and 1.75 μM in a cAMP assay and β-arrestin assay, respectively.
||ML239 is a potent and selective inhibitor of breast cancer stem cells, with an IC50 of 1.16 μM, with ~24-fold selectivity against the control cell line.
||ML240 is an ATP-competitive inhibitor of p97 ATPase with an IC50 of 0.11 μM and a Ki of 0.22 μM.
||ML241 hydrochloride is a potent and selective inhibitor of p97 with IC50 of 0.11 μM and 3.5 μM for p97 ATPase and UbG76V–GFP, respectively.
||ML251 is a potent inhibitor of T. brucei and T. cruzi phosphofructokinase.
||ML254 is shown to competitively interact with the MPEP allosteric binding site. ML254 can serve as a significant pure-PAM tool compound for the field with potential for studies within in vivo paradigms.
||ML264 (CID-51003603), a selectively inhibitor of kruppel-like factor 5 (KLF5),potently Inhibits Growth of Colorectal Cancer.
||ML277 (CID-53347902) is a potent activator of KCNQ1 channels with an EC50 of 260 nM and shows >100-fold selectivity over KCNQ2 and KCNQ4.
||ML281 is a potent and selective inhibitor of Serine/threonine kinase 33 (STK33) with IC50 of 0.014 μM. ML281 is selectively toxic to KRAS-dependent cancer cell lines.
||ML298 (CID53393915) is a potent, specific inhibitor of Phospholipase D2 (PLD2) with IC50 of 355 nM.
||ML299 (VU0463568) is a dual inhibitor of PLD1 and PLD2 with IC50 of 6 nM and 20 nM, respectively.
||ML303 is a pyrazolopyridine influenza virus nonstructural protein 1 (NS1) antagonist with IC90 of 155 nM and EC50 of 0.7 μM for Influenza A virus H1N1.
||ML311 is a potent and selective Mcl-1/Bim interaction inhibitor.
||ML318 is a biaryl nitrile inhibitor of PvdQ acylase with IC50 of 20 nM for binding in the acyl-binding site. ML318 inhibits P. aeruginosa (PAO1) with IC50 of 19 μM. ML318 prevents pyoverdine production and limits the growth of P. aeruginosa under iron-limiting conditions.
||ML324 is a selective inhibitor of jumonji histone demethylase (JMJD2) with IC50 of 920 nM.
||ML327 is an isoxazole compound that blocks MYC expression and tumor formation in neuroblastoma. ML327 also restores E-cadherin expression with In-Cell Western EC50 of 1.0 μM. ML327 induces apoptosis.
||ML329 is an inhibitor of micropthalmia-associated transcription factor (MITF) that inhibits TRPM-1 promoter activity with IC50 of 1.2 μM.
||ML335 is a potent and selective TREK-1/2 activator. ML335 is an agonist for OPRM1-OPRD1 heterdimerization with an EC50 of 403 nM, and selectivities vs. OPRM1, OPRD1, and HTR5A of 37, 2.7, and >99, respectively.
||ML336 is a potent inhibitor of the Venezuelan equine encephalitis virus (VEEV) strain TC-83.
||ML346 is a Hsp70 activator and a novel modulator of proteostasis for protein conformational diseases.
||ML347 (LDN-193719) is a selective BMP receptor inhibitor with IC50 of 32 nM for ALK2, >300-fold selectivity over ALK3. Also inhibits ALK1 activity with IC50 of 46 nM.
||ML348 (GNF-Pf-1127) is a potent and selective APT1 (Acyl protein thioesterase 1)/lysophospholipase 1 (LYPLA1) inhibitor with Ki values of 280 nM and >10 μM for APT1 and APT2, respectively.
||ML349 is a potent and specific inhibitor of acyl protein thioesterase 2 (APT-2) with Ki of 120 nM. ML349 is also an inhibitor of LYPLA2 with IC50 of 144 nM.
||ML351 is a selective inhibitor of 15-Lipoxygenase-1 (15-LOX-1 or 12/15-LOX) with IC50 of 200 nM.
||ML355 is a potent and selective inhibitor of human 12-Lipoxygenase with an IC50 of 290 nM and shows excellent selectivity over related lipoxygenases and cyclooxygenases.
||ML359 is a small molecule inhibitor of protein disulfide isomerase （PDI).
||ML364 is a small molecule inhibitor of the deubiquitinase USP2 with an IC50 of 1.1 μM in a biochemical assay using an internally quenched fluorescent di-ubiquitin substrate.
||ML365 is a novel selective small molecule inhibitor of the TASK1 or potassium channel, subfamily K, member 9 (KCNK3).
||ML367 is a potent, micromolar inhibitor of ATPase family AAA domain-containing protein 5 (ATAD5) stabilization. ML367 blocks DNA repair pathways and general DNA damage responses including RPA32-phosphorylation and CHK1-phosphorylation in response to UV irradiation.
||ML382 is a potent and selective MrgX1 (Mas-related G protein-coupled receptor X1, MRGPRX1) positive allosteric modulator with EC50 of 190 nM.
||ML385 is a novel and specific NRF2 inhibitor with an IC50 of 1.9 μM. It inhibits the downstream target gene expression of NRF2. NRF2 regulates the activity of several ferroptosis and lipid peroxidation-related proteins.
||ML397 (VU0155094) is a positive allosteric modulator (PAM) with differential activity at the various group III mGlus.
||ML401, a potent chemical probe, selectively antagonizes G-protein coupled receptor 183 (GPR183, EBI2) with an IC50 of 1.03 nM, and displays activity in a chemotaxis assay with IC50 of 6.24 nM.
||ML406 is a small molecule probe that shows anti-tubercular activity via M.tuberculosis BioA (DAPA synthase) enzyme inhibition with an IC50 of 30 nM.
||ML417 is a selective and brain penetrant agonist of D3 dopamine receptor (D3R) with EC50 of 38 nM.
||ML418 is a potent, selective and CNS penetrating blocker of Kir7.1 potassium channel with IC50 of 310 nM. ML418 also potently inhibits Kir6.2/SUR1, and exhibits superior selectivity over other Kir channels.
||ML-792 is a potent and selective inhibitor of SUMO (small ubiquitin-like modifier)-activating enzyme (SAE). ML-792 inhibits SAE/SUMO1 and SAE/SUMO2 in ATP–inorganic pyrophosphate (PPi) exchange assays with IC50 of 3 nM and 11 nM, respectively.
||MLi-2 is an orally active and highly selective inhibitor of LRRK2. MLi-2 exhibits exceptional potency in a purified LRRK2 kinase assay in vitro with IC50 of 0.76 nM, a cellular assay monitoring dephosphorylation of LRRK2 pSer935 LRRK2 with IC50 of 1.4 nM, and a radioligand competition binding assay with IC50 of 3.4 nM.
||MLN-4760 (compound 16) is a potent and selective inhibitor of human angiotensin-converting enzyme 2 (ACE2) with IC50 of 0.44 nM. MLN-4760 also inhibits bovine carboxypeptidase A (CPDA) with IC50 of 27 μM.
||MLN120B (ML120B) is a potent, selective, reversible, and ATP-competitive inhibitor of IkappaB kinase beta (IKKβ) with an IC50 of 45 nM for recombinant IKKβ. MLN120B does not inhibit other IKK isoforms at IC50 below 50 μM.
||MLN8054 is a potent and selective inhibitor of Aurora A with IC50 of 4 nM in Sf9 insect cell. It is more than 40-fold selective for Aurora A than Aurora B. Phase 1.
||MLR-1023 (Tolimidone, CP-26154) is a Lyn kinase activator and a novel insulin receptor potentiator that elicits a rapid-onset and durable improvement in glucose homeostasis in animal models of type 2 diabetes.
||MLS-573151 is a selective cell division cycle 42 (Cdc42) inhibitor with an EC50 of 2 μM, which acts by blocking the binding of GTP to Cdc42.
||MLS000532223 is a high affinity, selective inhibitor of Rho family GTPases with EC50 ranging from 16 μM to 120 μM.
||MLT-748 is a potent, selective and allosteric inhibitor of MALT1 with IC50 of 5 nM, binding at the interface between the caspase and immunoglobulin (Ig3) domains by displacing Trp580 and locking the catalytic site in an inactive state.
||MM-102 (HMTase Inhibitor IX) is a high-affinity peptidomimetic MLL1 inhibitor with IC50 of 0.4 μM in a cell-free assay.
||MM3122 is a selective inhibitor of host cell serine protease TMPRSS2 (transmembrane protease serine 2) with IC50 of 0.34 nM against recombinant full-length TMPRSS2 protein.
||MMAF (Monomethylauristatin F) is a synthetic antineoplastic agent and a potent inhibitor of tubulin polymerization. MMAF (Monomethylauristatin F) is applied as a cytotoxic component of antibody-drug conjugates (ADCs) such as vorsetuzumab mafodotin, ABT-414 and SGN-CD19A.
||MMP-9-IN-1 (OUN87710) is a specific inhibitor of matrix metalloproteinase-9 (MMP-9). MMP-9-IN-1 selectively targets the hemopexin (PEX) domain of MMP-9 with Kd of 2.1 μM.
||MN-64 is a potent inhibitor of TNKS1 and TNKS2 with IC50 value of 6 and 72 nM, respectively.
||MN58b is a selective inhibitor of choline kinase α (CHKα) and inhibits phosphocholine synthesis. MN58b induces apoptosis to reduce cell growth. MN58b also has antitumoral activity.
||MNITMT is a more potent immunosuppressive agent without bone marrow toxicity.
||MNS is a tyrosine kinase inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively.
||Mobocertinib (TAK788, AP32788), an investigational TKI, is a potent, selective preclinical inhibitor of epidermal growth factor receptor (EGFR) and HER2 mutations. Mobocertinib (TAK788) is an antineoplastic agent.
||Mocetinostat (MGCD0103, MG0103) is a potent HDAC inhibitor with most potency for HDAC1 with IC50 of 0.15 μM in a cell-free assay, 2- to 10- fold selectivity against HDAC2, 3, and 11, and no activity to HDAC4, 5, 6, 7, and 8. Mocetinostat (MGCD0103) induces apoptosis and autophagy. Phase 2.
||Moclobemide (Ro 111163)
||Moclobemide is a MAO-A (5-HT) inhibitor with IC50 of 6.1 μM.
||Moexipril HCl (RS-10085) is a potent orally active nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor, used for the treatment of hypertension and congestive heart failure.
Mogrol is a biometabolite of mogrosides, possessing inhibition of the ERK1/2 and STAT3 pathways in leukemia cells, and supression of adipogenesis by reducing CREB activation and activating AMPK signaling.
||Mogroside II A2
Mogroside II-A2 is a triterpenoid glycoside and a nonsugar sweetener. Mogrosides are sweeter than sucrose. Mogrosides exhibit antioxidant, antidiabetic and anticancer activities.
Mogroside III is a triterpenoid glycoside and a nonsugar sweetener. Mogrosides are sweeter than sucrose. Mogrosides exhibit antioxidant, antidiabetic and anticancer activities.
Mogroside III-E, a cucurbitane-type compound isolated from <i>Siraitia grosvenorii</i>, inhibits NO release with anti-fibrotic activity.
Mogroside IV-E, a triterpenoid glycoside, is a nonsugar sweetener. Mogrosides are sweeter than sucrose. Mogrosides exhibit antioxidant, antidiabetic and anticancer activities.
Mogroside III-A1 is a triterpenoid glycoside and a nonsugar sweetener. Mogrosides are sweeter than sucrose. Mogrosides exhibit antioxidant, antidiabetic and anticancer activities.
||Moguisteine is a novel peripheral non-narcotic antitussive drug.
||Molibresib (I-BET-762, GSK525762, GSK525762A) is an inhibitor for BET proteins with IC50 of ~35 nM in a cell-free assay, suppresses the production of proinflammatory proteins by macrophages and blocks acute inflammation, highly selective over other bromodomain-containing proteins.
||Molidustat (BAY 85-3934)
||Molidustat (BAY 85-3934) is a potent hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor with IC50 of 480 nM, 280 nM, and 450 nM for PHD1, PHD2, and PHD, respectively. Phase 2.
||Molindone hydrochloride is the hydrochloride salt form of molindone, a conventional antipsychotic used in the therapy of schizophrenia. It is a dopamine D2/D5 receptor antagonist.
||Molnupiravir (EIDD-2801, MK-4482) is an orally bioavailable prodrug of the ribonucleoside analog β-d-N4-hydroxycytidine (NHC; EIDD-1931) with broad-spectrum antiviral activity against SARS-CoV-2, MERS-CoV, SARS-CoV, and the causative agent of COVID-19.
||Molsidomine (SIN-10, Corvaton, Morsydomine) is an orally active, long acting vasodilating drug. Molsidomine is metabolized in the liver to the active metabolite linsidomine. Linsidomine is an unstable compound that releases nitric oxide (NO) upon decay as the actual vasodilating compound.
||Momelotinib (CYT387, LM-1149 , CYT11387) is an ATP-competitive inhibitor of JAK1/JAK2 with IC50 of 11 nM/18 nM, ~10-fold selectivity versus JAK3. Momelotinib (CYT387) induces apoptosis and autophagy. Phase 3.
||Mometasone Furoate (SCH-32088) is a glucocorticoid receptor agonist, used topically to reduce inflammation of the skin or in the airways.
||Mometasone Furoate Hydrate
Mometasone Furoate (SCH 32088) Hydrate is a synthetic glucocorticoid with anti-inflammatory activity.
||Momordica grosvenori Extract
||Momordicae Semen Extract
||Momordin Ic, a natural triterpenoid saponin, is a novel SENP1 (SUMO-specific protease 1) inhibitor that inhibited proliferation of prostate cancer cells in vitro and in vivo.
Monascin, a kind of azaphilonoid pigments extracted from <i>Monascus pilosus</i>-fermented rice (red-mold rice), exhibits anti-tumor-initiating and anti-inflammatory activities with oral administration.
||Monastrol ((±)-Monastrol) is a cell-permeable small molecule inhibitor of kinesin-5(KIF11) which is essential for maintaining separation of the half-spindles.
||MONNA is a potent TMEM16A (Anoctamin-1) blocker with IC50 of 80 nM. MONNA induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions.
||Monobenzone is a compound used as a topical agent for medical depigmentation. It can specifically block tyrosinase.
||Monobutyl phtalate is a metabolite of di(n-butyl)phthalate. It affects the expressions of EMT-related proteins and enhances the migration and invasion of MLTC-1 cells.
||Monocaprylin (2,3-dihydroxypropyl octanoate, Monoctanoin, 1-Octanoyl-rac-glycerol, MC) exhibits an excellent antibacterial activity against Staphylococcus aureus and Escherichia coli.
||Monocrotaline (MCT, Crotaline) is an 11-membered macrocyclic pyrrolizidine alkaloid (PA) that causes a pulmonary vascular syndrome in rats characterized by proliferative pulmonary vasculitis, pulmonary hypertension, and cor pulmonale.
||Monoethyl malonic acid
Monoethyl malonic acid (Ethyl hydrogen malonate, Monoethyl malonate, 3-Ethoxy-3-oxopropanoic acid) is the major urinary metabolites of ethyl 3-ethoxypropionate (EEP).
||Monoethyl pimelate is a PROTAC linker that refers to the alkyl/ether composition. Monoethyl pimelate is applicable to the synthesis of (S,R,S)-AHPC-Me-C7 ester, a specific BCL-XL PROTAC degrader.
||Monomethyl auristatin E (MMAE)
||Monomethyl auristatin E (MMAE, SGD-1010) is a synthetic antineoplastic agent, which is linked to a monoclonal antibody (MAB). It is also a microtubule-disrupting agent .
||Monomethyl Fumarate (MMF, Monomethylfumarate, Fumaric acid monomethyl ester, Methyl hydrogen fumarate), the active metabolite of the psoriasis drug Fumaderm, is a potent GPR109A agonist. Monomethyl Fumarate prevents major dysfunctions associated with neurodegenerative diseases: oxidative stress, mitochondrial dysfunction, apoptosis and autophagy.
||Monomethyl glutaric acid (5-Methoxy-5-oxopentanoic acid) is a dicarboxylic acid monoester and has a role as a human urinary metabolite.
||Monomyristin (Glyceryl myristate, 2,3-Dihydroxypropyl tetradecanoate), a monoacylglyceride, shows high antibacterial and antifungal activities.
||Montelukast is a leukotriene receptor antagonist used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies.
||Montelukast (MK-0476) selectively antagonizes leukotriene D4 (LTD4) by binding to it so that block the action of leukotriene D4 on the cysteinyl leukotriene receptor CysLT1. Montelukast improves macroautophagy but not the chaperone-mediated autophagy pathway. Precipitations may form after reconstitution,solution is best fresh-prepared.
||Morantel (CP-12009-18, UK 296418) is a positive allosteric modulator of neuronal nicotinic acetylcholine receptors (nAChRs).
||Morin (Al-Morin, Aurantica, Calico Yellow, Toxylon pomiferum), a constituent of various woods, has a role as an antioxidant, a metabolite, an antihypertensive agent, a hepatoprotective agent, a neuroprotective agent, an anti-inflammatory agent, an antineoplastic agent, an antibacterial agent, a DNA topoisomerase inhibitor and an angiogenesis modulating agent.
||Morin hydrate (Aurantica) is a flavonoid isolated from Maclura pomifera (Osage orange), Maclura tinctoria (old fustic) and from leaves of Psidium guajava (common guava).
||Morinda Root Extract
||Moringa oleifera leaf Extract
||Moringa pterygosperma seed Extract
||Moroxydine HCl is a synthetic antiviral compound chemically belonging to the series of the heterocyclic biguanidines.
||Morphothiadin (GLS4) is a potent inhibitor on the replication of both wild-type and adefovir-resistant Hepatitis B virus (HBV) with an IC50 of 12 nM. Morphothiadin (GLS4), a nucleoside analogs that target the virus polymerase, can block the HBV replication cycle and HBV-associated chronic liver diseases.
||Morroniside, an iridoid glycoside, is the main active ingredient from Cornus officinalis Sieb. et Zucc. and Sambucus williamsii Hance. It has therapeutic effects on diabetic angiopathies, renal damage, lipid metabolism and inflammation and bone resorption. Morroniside has neuroprotective effect by inhibiting neuron apoptosis and MMP2/9 expression.
||Morus alba bark Extract
||Morusin (Mulberrochromene) is an inhibitor of NF-κB and STAT3. Morusin is a prenylated flavonoid isolated from M. australis with antitumor, antioxidant, and anti-bacteria properties.
||Mosapride is a gastroprokinetic agent that acts as a selective 5HT4 agonist.
||Mosapride Citrate (AS-4370) is a gastroprokinetic agent that acts as a selective 5HT4 agonist.
Mosloflavone is a flavonoid isolated from Scutellaria baicalensis Georgi, which has antiviral and antibacterial activity.
Moslosooflavone is a flavonoid isolated from Saussurea involucrata. Moslosooflavone has an anti-hypoxia and anti-inflammatory activities.
||Motesanib (AMG-706) is an orally bioavailable receptor tyrosine kinase inhibitor with IC50 values of 2 nM, 3 nM, 6 nM, 8 nM, 84 nM, 59 nM for VEGFR1, VEGFR2, VEGFR3, Kit, PDGFR and Ret, respectively.
||Motesanib Diphosphate (AMG-706)
||Motesanib Diphosphate (AMG-706) is a potent ATP-competitive inhibitor of VEGFR1/2/3 with IC50 of 2 nM/3 nM/6 nM, respectively; similar activity against Kit (c-Kit), ~10-fold more selective for VEGFR than PDGFR and Ret. Phase 3.
||Motixafortide (BL-8040, BKT140, TF 14016, 4-fluorobenzoyl, 4F-benzoyl-TN14003, T140) is an antagonist of CXCR4 with IC50 of ～1 nM. BL-8040 induces the apoptosis of AML blasts by down-regulating ERK, BCL-2, MCL-1 and cyclin-D1 via altered miR-15a/16-1 expression.
||Motolimod (VTX-2337) is a selective and potent Toll-like receptor 8 (TLR8) agonist with EC50 of 100 nM, > 50-fold selectivity over TLR7. Phase 2.
||MOTS-c, a mitochondria-derived peptide (MDP), exerts antinociceptive and anti-inflammatory effects through activating AMPK pathway and inhibiting MAP kinases-c-fos signaling pathway.
||Mouse IgG2a isotype control-InVivo
||Mouse IgG2a isotype control-InVivo (Clone:C1.18.4) monoclonal antibody is ideal for use as a non-reactive isotype-matched control for mouse IgG2a antibodies in most in vivo and in vitro applications.
||Mouse Metabolite Compound Library
||A unique collection of 163 mouse metabolites used for high throughput screening(HTS) and high content screening(HCS).
||Moxidectin (Milbemycin B) is a potent, broad-spectrum endectocide with activity against a wide range of nematodes, insects and acari.
||Moxifloxacin is an antibiotic used to treat a number of bacterial infections, active against Mycobacterium tuberculosis in vitro.
||Moxifloxacin (BAY12-8039) HCl
||Moxifloxacin (BAY12-8039) is a fourth-generation synthetic fluoroquinolone antibacterial agent.
||Moxisylyte hydrochloride (thymoxamine) is an alpha-adrenergic blocking agent used for the treatment of Raynaud's disease.
||Moxonidine (BDF5895) is a selective agonist at the imidazoline receptor subtype 1, used as antihypertensive agent.
||Mozavaptan (OPC-31260) is a novel competitive vasopressin receptor antagonist for both V1 and V2 receptors with IC50 of 1.2 μM and 14 nM, respectively.
||MP-A08 is a highly selective ATP competitive sphingosine kinase (SK) inhibitor that targets both SK1 and SK2.
||MP07-66, a FTY720 analogue, is devoid of immunosuppressive effects and shows promising antitumor effects in chronic lymphocytic leukemia by disruption of the SET-PP2A complex leading to PP2A reactivation.
||MPEP is a selective mGlu5 receptor antagonist with IC50 of 36 nM, exhibits no appreciable activity at mGlu1b/2/3/4a/7b/8a/6 receptors.
||MPI-0479605 is an ATP competitive and selective inhibitor of mitotic kinase Mps1 with IC50 of 1.8 nM, >40-fold selectivity over other kinases.
||MPI-5a is a potent and selective inhibitor of HDAC6 with IC50 of 36 nM. MPI-5a inhibits acyl-tubulin accumulation in cells with IC50 of 210 nM.
||MPO-IN-28 (Compound 28) is an inhibitor of myeloperoxidase (MPO) with IC50 of 44 nM.
||MPP+ iodide (N-Methyl-4-Phenylpyridinium Iodide), the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces autophagic cell death in SH-SY5Y cells. MPP+ induces dopamine transporter (DAT) externalization in dopaminergic (DA) neurons, but internalization of serotonin transporter (SERT) in serotonergic (5-HT) neurons.
||MPTP hydrochloride is a dopaminergic neurotoxin and cause selective destruction of dopaminergic neurons in animal models of parkinsonism. MPTP hydrochloride induces apoptosis.
MQAE (1-(Ethoxycarbonylmethyl)-6-methoxyquinolinium bromide, N-[ethoxycarbonylmethyl]-6-methoxy-quinolinium bromide) is a 'non-ratiometric'chloride ion (Cl−)-quenched fluorescent indicator that is used to determine intracellular Cl− concentration ([Cl−] i).
||MRE-269 (ACT-333679) is a prostaglandin I2 (IP) receptor agonist with a binding affinity for the human IP receptor that is 130-fold greater than that for other human prostanoid receptor.
||MRGPRX1 agonist 1
MRGPRX1 agonist 1 is a highly potent agonist of MRGPRX1 with an EC50 of 50 nM.
||MRS2578 is a potent P2Y6 receptor antagonist with IC50 of 37 nM, exhibits insignificant activity at P2Y1, P2Y2, P2Y4,and P2Y11 receptors.
||MRT-10 inhibits ShhN signaling in Shh-light2 cells in a dose-dependent manner with IC50 of 0.64 μM, showing the capacity to abrogate the constitutive activity of Smo.
||MRT-81 is a potent antagonist of human and rodent smoothened (Smo) receptors, with an IC50 value of 41 nM in the Shh-light2 cells, exerting potent hedgehog (Hh) signaling pathway inhibiting activity.
MRT-83 is a potent antagonist of Smo and displays full antagonist properties with an IC50 of ~3 nM for inhibiting ShhN (3 nM)-induced proliferation of rat GCPs.
MRT67307 (IKKε/TBK1 Inhibitor II) inhibits IKKε and TBK1 with IC50 values of 160 nM and 19 nM at 0.1 mM ATP in vitro, but does not inhibit IKKα or IKKβ even at 10 μM. MRT67307 also is a highly potent ULK1 and ULK2 inhibitor with IC50s of 45 and 38 nM, respectively. MRT67307 can blocks autophagy in cells.
||MRT67307 is a potent and dual IKKϵ and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively. MRT67307 potently inhibits ULK1 and ULK2 and blocks autophagy.
||MRT68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively.
||MRTX-1257 is a potent, selective, irreversible, covalent and orally active inhibitor of KRAS G12C with IC50 of 900 pM for KRAS dependent ERK phosphorylation in H358 cells.
||MRTX0902 is a potent SOS1 inhibitor for therapeutic intervention of KRAS-driven cancers with an IC50 of 46 nM.
MRTX1133 is a highly selective inhibitor of mutant KRAS G12D and can reversibly binds to the activated and inactivated KRAS G12D mutants and inhibit their activity. The specificity of MRTX1133 to KRAS G12D is more than 1000 times that of wild-type KRAS.
||MRTX1719 is a synthetic lethal inhibitor of the PRMT5/MTA complex and selectively inhibits PRMT5 activity in MTAP-deleted cells compared to MTAP-wild-type cells.
||MRX-2843 (UNC2371) is an orally active dual inhibitor of tyrosine kinases MERTK and FLT3 with IC50 of 1.3 nM and 0.64 nM, respectively.
||MS140 is a specific and highly potent CDK4/6 kinase inhibitor and also a CDK4/6 degrader (PROTAC).
||MS1943 is an orally bioavailable EZH2 selective degrader that effectively reduces EZH2 levels in cells with IC50 of 120 nM for inhibiting EZH2 methyltransferase activity.
MS37452 is a competitive inhibitor of CBX7 chromodomain binding to H3K27me3 with a Ki of 43 µM.
||MS402 is a BD1-selective BET BrD inhibitor that inhibits Th17 cell differentiation.
||MS4078 is an inhibitor and PROTAC (degrader) of ALK. MS4078 reduces the NPM-ALK protein levels in SU-DHL-1 cells and the EML4-ALK protein levels in NCI-H2228 cells with DC50 of 11 nM and 59 nM, respectively. MS4078 induces ALK protein degradation via cereblon and proteasome dependent mechanism and potently inhibits proliferation of SU-DHL-1 cells with IC50 of 33 nM.
||MS7972 is a small molecule that blocks human p53 and CREB binding protein association.
||MSA-2 is an orally available non-nucleotide human STING agonist with antitumor activity.
||MSAB is a selective inhibitor of Wnt/β-catenin signaling that binds to β-catenin, promoting its degradation, and specifically downregulates Wnt/β-catenin target genes. MSAB shows potent anti-tumor effects.
||MSBN is a highly selective fluorogenic probe for thiols that selectively images thiols in live cells and specifically labels protein thiols with a turn-on signal to determine diverse reversible protein thiol modifications.
||MSC2530818, a CDK8 inhibitor with the IC50 of 2.6 nM, displays excellent kinase selectivity, biochemical and cellular potency, microsomal stability, and is orally bioavailable.
||MSDC-0160 (CAY10415) is a prototype mTOT-modulating insulin sensitizer being studied to treat diabetes and Alzheimer's disease. Phase 2.
MSDC-0602K is a insulin sensitizer that modulates the mitochondrial pyruvate carrier (MPC).
||MSX-122 is a novel small molecule and partial CXCR4 antagonist (IC50~10 nM).
||MSX-127 (NSC-23026) is a C-X-C chemokine receptor type 4 (CXCR4) receptor antagonist.
||MSX-130 is an antagonist of C-X-C chemokine receptor type 4 (CXCR4).
||MT-802 is a potent PROTAC that induces Bruton's tyrosine kinase (BTK) knockdown. MT-802 recruits BTK to the cereblon E3 ubiquitin ligase complex to trigger BTK ubiquitination and degradation via the proteasome. MT-802 has potential for treatment of C481S mutant chronic lymphocytic leukemia (CLL).
||MTI-31 (LXI-15029) is a novel mTORC1/mTORC2 inhibitor with Kd of 0.2 nM in mTOR binding assays and displays >5,000-fold selectivity over PIK3CA, PIK3CB and PIK3G.
||mTOR inhibitor-1 is a novel mTOR pathway inhibitor which can suppress cells proliferation and inducing autophagy.
||MTX-211 is a first-in-class dual inhibitor of PI3K and EGFR kinase.
||Mubritinib (TAK 165)
||Mubritinib (TAK-165) is a potent inhibitor of HER2/ErbB2 with IC50 of 6 nM in BT-474 cell; no activity to EGFR, FGFR, PDGFR, JAK1, Src and Blk in BT-474 cell line. Phase 1.
||Mucic Acid (Schleimsaure, Saccharolactic acid, Tetrahydroxyadipic acid, D-Glucaric acid, Galactaric acid) is the dicarboxylic sugar acid resulting from oxidation glactose with dilute nitric acid. It is a substrate of galactarate O-hydroxycinnamoyltransferase.
Mudanpioside C is a monoteepenoid isolated from Paeonia lactiflora Pall.
||Muira Puama Extract
||Mulberrin is a natural product found in Morus lhou, Artocarpus and other organisms with data available, with strong inhibition effect on organic anion-transporting polypeptide 2B1 (OATP2B1)-mediated estrone-3-sulfate (E3S) uptake.
||Mulberroside A, isolated from the ethanol extract of Morus alba roots, is widely employed as an active ingredient in cosmetic products due to its anti-tyrosinase and anti-oxidant activities. Mulberroside A decreases the expressions of TNF-α, IL-1β and IL-6 and inhibits the activation of NALP3, caspase-1 and NF-κB and the phosphorylation of ERK, JNK and p38.
||Mulberry Extract (leaves)
||Mulberry Extract (leaves) is extracted from Mulberry (Morus alba L.) leaves , which are traditional Chinese herbs. Mulberry leaves exert several biological functions, such as antioxidant, anti-inflammation, antidiabetic, and antitumor.
||Mung bean peel Extract
||Mupirocin is an isoleucyl t-RNA synthetase inhibitor, used in the treatment of bacterial skin infections.
||Mupirocin Calcium (Pseudomonic acid A) is the calcium salt form of mupirocin, a natural crotonic acid derivative extracted from Pseudomonas fluorescens,which inhibits bacterial protein synthesis and is used as an antibiotic.
||Muramyl dipeptide (MDP) is a shared structural unit of peptidoglycans. Muramyl dipeptide is an inducer of bone formation through the induction of Runx2.
||MuRF1-IN-1 is a muscle ring finger protein-1 (MuRF1) inhibitor that attenuates skeletal muscle atrophy and dysfunction in cardiac cachexia.
||Muscone (3-Methylcyclopentadecanone, Methylexaltone), a flavouring ingredient, is an organic compound that is the primary contributor to the odor of musk and also a potent anti-inflammatory agent. Muscone significantly downregulats the levels of LPS-induced inflammatory cytokines and inhibits NF-κB and NLRP3 inflammasome activation in BMDMs. Muscone remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and IL-6).
||Mutant IDH1 inhibitor
||Mutant IDH1 inhibitor is a potent inhibitor of mutant IDH1 R132H with IC50 of < 72 nM.
||Mutated EGFR-IN-1 (Osimertinib analog) is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activating mutant and T790M resistance mutant.
||MW150 (MW01-18-150SRM) is a selective, CNS-penetrant and orally active inhibitor of p38α MAPK with Ki of 101 nM. MW-150 inhibits the ability of the endogenous p38α MAPK to phosphorylate an endogenous substrate MK2 in activated glia.
||MYCi361 is a MYC inhibitor that engages MYC inside cells, disrupts MYC/MAX dimers, and impairs MYC-driven gene expression. MYCi361 binds to MYC with Kd of 3.2 μM. MYCi361 suppresses in vivo tumor growth, increases tumor immune cell infiltration, upregulates PD-L1 on tumors, and sensitizes tumors to anti-PD1 immunotherapy.
||MYCi975 (NUCC-0200975) is a potent, selective and orally active inhibitor of MYC that disrupts MYC/MAX interaction, promotes MYC T58 phosphorylation and MYC degradation, and impairs MYC driven gene expression. MYCi975 exhibits potent anti-tumor activities.
||Myclobutanil is a widely used triazole fungicide and also a steroid demethylation inhibitor.
||Mycophenolate mofetil (RS-61443)
||Mycophenolate Mofetil (RS 61443, Mycophenolic acid morpholinoethyl ester, CellCept, TM-MMF) is a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase I/II with IC50 of 39 nM and 27 nM, respectively. Mycophenolate Mofetil induces caspase-dependent apoptosis and cell cycle inhibition in multiple myeloma cells.
||Mycophenolic acid (Mycophenolate, RS-61443) is a potent IMPDH inhibitor and the active metabolite of an immunosuppressive drug, used to prevent rejection in organ transplantation.
||Mycro 3 is a potent and selective inhibitor of c-Myc in whole cell assays. Mycro 3 also shows weak inhibitory activity against AP-1.
||Myelin Oligodendrocyte Glycoprotein 35-55, mouse, rat
||Myelin Oligodendrocyte Glycoprotein 35-55, mouse, rat (MOG 35-55) is a minor component of CNS myelin that induces experimental autoimmune encephalomyelitis in C57BL/6 mice by an encephalitogenic T cell response.
||MYF-01-37 is a novel covalent inhibitor of TEAD targeting Cys380 when incubated with the TEAD2 protein.
||MYLS22 is a first-in-class and selective inhibitor of optic atrophy 1 (OPA1) with anti-angiogenesis and anti-cancer activity.
||Myoseverin is a microtubule-binding trisubstituted purine, reversibly altering cellular function, directly binds tubulin and disrupts the structure of the microtubule cytoskeleton resulting in myotube fission at 20 μM.
Myosmine is not only one of the minor tobacco alkaloids but is also present in various foods. Myosmine has low affinity against a4b2 nicotinic acetylcholinergic receptors (nAChR) with Ki of 3300 nM.
||Myricitrin (Myricitrine), a flavonoid compound isolated from the root bark of Myrica cerifera, which exerts antinociceptive effects.
||Myrislignan, a lignan isolated from Myristica fragrans Houtt, possesses anti-inflammatory activities. Myrislignan inhibits interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α). Myrislignan significantly inhibits the expressions of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) dose-dependently in LPS-stimulated macrophage cells. Myrislignan inhibits the NF-κB signalling pathway activation.
||Myristic acid (Tetradecanoic acid) is a fatty acid that occurs naturally in some foods. Myristic acid inhibits the phosphorylation of poly E4Y by Src with an Ki of 35 μM.
||Myristica fragrans Extract
||Myristicin (Myristicine), a terpene-like active component in Nutmeg which is the seed of Myristica fragrans, is a weak inhibitor of monamine oxidase (MAO) and a mechanism-based inhibitor of CYP1A2.
||Myristicin Aldehyde is a natural product found in Magnolia denudata .
||MZ-1 is a PROTAC degrader of bromodomain-containing protein 4 (BRD4). MZ-1 binds to the Brd bromodomain with Kd of 62 nM, 60 nM, 21 nM, 13 nM, 39 nM and 15 nM for Brd2BD1, Brd2BD2, Brd3BD1, Brd3BD2, Brd4BD1 and Brd4BD2.
||γ-Mangostin (Gamma-Mangostin) is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptors antagonist, which can reduce the perfusion pressure response of rat coronary artery to 5-HT2A with an IC50 of 0.32 µM and inhibit [3H] spiperone binding to cultured rat aortic myocytes with an IC50 of 3.5 nM. Gamma-Mangostin is also an inhibitor of Transthyretin (TTR) fibrillization.