Amantadine

Catalog No.S5499 Synonyms: 1-Adamantanamine, 1-Adamantylamine, 1-Aminoadamantane

For research use only.

Amantadine (1-Adamantanamine, 1-Adamantylamine, 1-Aminoadamantane) is an antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is an M2 inhibitor which blocks the ion channel formed by the M2 protein that spans the viral membrane.

Amantadine Chemical Structure

CAS No. 768-94-5

Purity & Quality Control

Choose Selective Influenza Virus Inhibitors

Biological Activity

Description Amantadine (1-Adamantanamine, 1-Adamantylamine, 1-Aminoadamantane) is an antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is an M2 inhibitor which blocks the ion channel formed by the M2 protein that spans the viral membrane.
Targets
M2 [1]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 151.25
Formula

C10H17N

CAS No. 768-94-5
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1C2CC3CC1CC(C2)(C3)N

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04530006 Recruiting Diagnostic Test: Amantadine Hydrochloride Glioblastoma Multiforme CancerCare Manitoba|University of Manitoba|The Metabolomics Innovation Centre|BioMark Diagnostics Inc.|Canadian Institutes of Health Research (CIHR) December 2 2020 Not Applicable
NCT02277938 Recruiting Drug: Amantadine Cancer University of Manitoba|BioMark Technologies Inc.|St. Boniface Hospital August 2013 --
NCT01491529 Completed Drug: AFQ056|Drug: Placebo Dyskinesias|Parkinson Disease|Movement Disorders|Parkinsonian Disorders|Anti-Dyskinesia Agents Novartis Pharmaceuticals|Novartis April 2012 Phase 2
NCT01467258 Completed Drug: Amantadine Healthy Metabolism University of Manitoba|St. Boniface Hospital November 2011 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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