Home MAPK p38 MAPK inhibitor Adezmapimod hydrochloride

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Adezmapimod hydrochloride p38 MAPK inhibitor

Cat.No.E4791

Adezmapimod hydrochloride (RWJ 64809 hydrochloride, SB 203580 hydrochloride) is an inhibitor of the MAPK family member termed as stress-activated protein kinase 2a(SAPK2a; also known as p38). It exhibits IC50 of SAPK2a/p38 and SAPK2b/p38β2 with IC50 values of 50 nM and 500 nM respectively and can be used in research of chronic inflammatory diseases, such as rheumatoid arthritis.
Adezmapimod hydrochloride p38 MAPK inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 413.90

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Quality Control

Batch: E479101 DMSO]83 mg/mL]false]Water]4 mg/mL]false]Ethanol]Insoluble]false Purity: 98.26%
98.26

Chemical Information, Storage & Stability

Molecular Weight 413.90 Formula

C21H16FN3OS.ClH

 Storage (From the date of receipt)
CAS No. 869185-85-3 Download SDF Storage of Stock Solutions

Solubility

In vitro
Batch:

DMSO : 83 mg/mL (200.53 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 4 mg/mL

Ethanol : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Mechanism of Action

Targets/IC50/Ki
p38 [1]
50 nM
p38β [1]
500 nM
References

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