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Amifostine trihydrate

Name: Amifostine trihydrate
Brand: Selleck Chemicals
SKU: S4298
Rating: 5 (7 reviews)

Synonyms: WR2721 trihydrate

Catalog No.S4298 Purity: 97%

Amifostine trihydrate(WR2721 trihydrate) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.

Amifostine trihydrate Chemical Structure

CAS: 112901-68-5

Selleck's Amifostine trihydrate has been cited by 7 publications

Purity & Quality Control

Batch: Purity: >97%

Amifostine trihydrate Related Products

Biological Activity

Description	Amifostine trihydrate(WR2721 trihydrate) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT00086099	Completed	Leukemia\|Acute Myeloid Leukemia	MedImmune LLC	July 2004	Phase 1\|Phase 2
NCT00130143	Completed	Head and Neck Cancer\|Lung Cancer	The Dale & Frances Hughes Cancer Center\|MedImmune LLC	June 2003	Not Applicable
NCT00136474	Completed	Lymphoma\|Hodgkin''s Disease\|Non-Hodgkin''s Lymphoma	Dana-Farber Cancer Institute\|Brigham and Women''s Hospital\|Beth Israel Deaconess Medical Center\|MedImmune LLC	May 2003	Phase 2

Chemical Information & Solubility

Molecular Weight	268.27	Formula	C₅H₁₅N₂O₃PS.3H₂O
CAS No.	112901-68-5	SDF	Download Amifostine trihydrate SDF
Smiles	C(CN)CNCCSP(=O)(O)O.O.O.O
Storage (From the date of receipt)	Store at 4℃	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	Store at 4℃		1 month-20°Cin solvent

In vitro
Batch:

Water : 54 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
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