Amifostine trihydrate

Catalog No.S4298

For research use only.

Amifostine trihydrate is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.

Amifostine trihydrate Chemical Structure

CAS No. 112901-68-5

Selleck's Amifostine trihydrate has been cited by 5 Publications

Purity & Quality Control

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Biological Activity

Description Amifostine trihydrate is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.

Protocol (from reference)

Solubility (25°C)

In vitro

Water 42 mg/mL warmed
(156.55 mM)
DMSO Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 268.27
Formula

C5H15N2O3PS.3H2O

CAS No. 112901-68-5
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C(CN)CNCCSP(=O)(O)O.O.O.O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT00086099 Completed Drug: Idarubincin and Amufostine (Ethyol)|Drug: Idarubincin Leukemia|Acute Myeloid Leukemia MedImmune LLC July 2004 Phase 1|Phase 2
NCT00130143 Completed Drug: Ethyol (Amifostine) Head and Neck Cancer|Lung Cancer The Dale & Frances Hughes Cancer Center|MedImmune LLC June 2003 Not Applicable
NCT00136474 Completed Drug: Amifostine|Radiation: Radiation Therapy Lymphoma|Hodgkin''s Disease|Non-Hodgkin''s Lymphoma Dana-Farber Cancer Institute|Brigham and Women''s Hospital|Beth Israel Deaconess Medical Center|MedImmune LLC May 2003 Phase 2

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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