Acetohydroxamic acid

Catalog No.S4602 Synonyms: N-Hydroxyacetamide, Methylhydroxamic acid, Acetic acid|oxime, Lithostat

For research use only.

Acetohydroxamic acid (N-Hydroxyacetamide, Methylhydroxamic acid, Acetic acid|oxime, Lithostat) is an Urease Inhibitor. In the urine, it acts as an antagonist of the bacterial enzyme urease.

Acetohydroxamic acid Chemical Structure

CAS No. 546-88-3

Purity & Quality Control

Choose Selective Bacterial Inhibitors

Biological Activity

Description Acetohydroxamic acid (N-Hydroxyacetamide, Methylhydroxamic acid, Acetic acid|oxime, Lithostat) is an Urease Inhibitor. In the urine, it acts as an antagonist of the bacterial enzyme urease.
Targets
Urease [1]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 15 mg/mL
(199.81 mM)
Water 15 mg/mL
(199.81 mM)
Ethanol '15 mg/mL

Chemical Information

Molecular Weight 75.07
Formula

C2H5NO2

CAS No. 546-88-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC(=O)NO

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04242823 Recruiting Diagnostic Test: Automated visual evaluation Cervical Cancer|Prevention Beth Israel Deaconess Medical Center|University of Botswana|Botswana Harvard AIDS Institute Partnership February 22 2021 Not Applicable
NCT04461119 Completed Drug: Evenamide|Drug: Placebo Schizophrenia Newron Pharmaceuticals SPA June 16 2020 Phase 2
NCT04120246 Recruiting Drug: Alpha-tocopheryloxyacetic Acid|Biological: Trastuzumab Anatomic Stage IV Breast Cancer AJCC v8|HER2 Positive Breast Carcinoma|Metastatic Breast Carcinoma|Prognostic Stage IV Breast Cancer AJCC v8|Refractory Breast Carcinoma University of Washington|Veana Therapeutics Inc. April 8 2020 Phase 1
NCT03722381 Withdrawn Drug: Amlodipine Besylate Hemodialysis|Pharmacokinetics University of Michigan January 2020 --
NCT04157803 Unknown status Diagnostic Test: Acetic acid % spray Colonic Polyp Hospital Aleman October 25 2019 Not Applicable
NCT04117191 Completed Dietary Supplement: Doctor''s Best L-Tryptophan Healthy|Chronic Kidney Diseases Taipei Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation October 1 2019 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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