(+)-Nortrachelogenin, a pharmacologically ligand from from wikstroemia indica, possesses antileukemic activity.
||(−)-Norepinephrine (Arterenol, Levarterenol, L-Noradrenaline) is a natural neurotransmitter and hormone. It is an agonist of adrenergic receptors with Ki values of 330, 56, and 740 nM for α1, α2, and β1 adrenoceptors, respectively.
||1,4-Naphthoquinone (α-Naphthoquinone, para-naphthoquinone, P-Naphthoquinone), found in diesel exhaust particles and it is an active metabolite of naphthalene, is a fumigant insecticide.
||1-Naphthaleneacetic acid (α-Naphthaleneacetic acid) is a synthetic plant hormone in the auxin family.
||1-Naphthyl acetate is usually used in a rapid staining method for identification of macrophages. 1-Naphthyl acetate is a potent chromogenic substrate for the detection of erythrocyte acetylcholinesterase (AChE) activity.
||1-Naphthyl phosphate potassium salt
||1-Naphthyl phosphate potassium salt (α-Naphthyl acid phosphate monopotassium salt) is a non-specific phosphatase inhibitor which acts on acid, alkaline, and protein phosphatases.
||1-Naphthyl PP1 hydrochloride
||1-Naphthyl PP1 hydrochloride (1-NA-PP 1 hydrochloride) is a selective inhibitor of Src family kinases, inhibits v-Src, c-Fyn, c-Abl, CDK2 and CAMKII with IC50s of 1.0, 0.6, 0.6, 18 and 22 μM, respectively.
||1-Naphthyl PP1(1-NA-PP 1) is a highly selective and potent pan-PKD inhibitor with IC50 of 154.6 nM,133.4 nM and 109.4 nM for PKD1, PKD2 and PKD3, respectively. 1-Naphthyl PP1 is a selective inhibitor of Src family kinases (v-Src, c-Fyn) and the tyrosine kinase c-Abl with IC50 of 1.0 μM, 0.6 μM, 0.6 μM, 18 μM and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II, respectively.
||1-NM-PP1 (PP1 Analog II, 1NM-PP1, analogue 9) is a potent inhibitor of Src family kinases with IC50 of 4.3 nM and 3.2 nM for v-Src-as1 and c-Fyn-as1, respectively. 1-NM-PP1 also inhibits CDK2-as1, CAMKII-as1 and c-Abl-as2 with IC50 of 5.0 nM, 8.0 nM and 120 nM, respectively.
||2-Naphthol (2-Hydroxynaphthalene, 2-Naphthalenol, beta-Naphthol, Naphth-2-ol, β-naphthol), a potential antinematodal drug, is a widely used intermediate for the production of dyes and other compounds.
||2-NBDG, a fluorescent deoxyglucose derivative, is a a marker for detecting glucose uptake and an indicaotr of cell viability.
||2-NP-AOZ is a 2-nitrophenyl derivative of AOZ (a tissue-bound metabolite of the Furazolidone) that can be used for determination of the AOZ residues.
24-norursodeoxycholic acid (norUDCA), a side chain-shortened C23 homologue of UDCA, exhibits potent anti-cholestatic, anti-inflammatory and anti-fibrotic properties.
||3-n-Butylphathlide, initially isolated from the seeds of Apium graveolens Linn., has shown significant neuroprotective effects.
||3-Nitro-L-tyrosine (3-NT, N-Tyr, MNT), synthesized from L-tyrosine by peroxynitrite, is a product of nitric oxide and superoxide. 3-Nitro-L-tyrosine inhibits the hemodynamic responses to angiotensin II, possibly through the inhibition of alpha 1-adrenoceptor-mediated events.
||3-Nitropropionic acid (β-Nitropropionic Acid, 3-NP) is an irreversible inhibitor of mitochondrial respiratory Complex II succinate dehydrogenase, resulting in energy depletion through disruption of the electron transport chain.
||4-N3Pfp-NHS ester is a non-cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
||4-Nitrophenol (p-nitrophenol, 4-hydroxynitrobenzene) is a phenolic compound that can be used as a pH indicator and an intermediate in the synthesis of paracetamol.
4-Nitroquinoline 1-oxide (4-Nitroquinoline-N-oxide, 4-NQO, 4NQO, 4Nqo, NQO, NQNO) is a highly carcinogenic model chemical that induces mutations in bacteria, fungi, and animals through the formation of bulky purine adducts.
||5'-N-Ethylcarboxamidoadenosine (NECA, 5'-(N-Ethylcarboxamido)adenosine, Adenosine-5'N-ethylcarboxamide, 5'-Ethylcarboxamidoadenosine) is a stable, nonselective adenosine receptor agonist. 5'-N-Ethylcarboxamidoadenosine acts via multiple mechanisms including: reducing diabetes-induced oxidative stress, inhibiting gene expression of IL-18, TNF-α and ICAM-1 (intercellular adhesion molecule 1 (CD54)), and blocking activation of the JNK-MAPK pathway.
||5-(N-Ethyl-N-isopropyl)-Amiloride (EIPA) acts as an inhibitor of macropinocytosis and sodium-hydrogen exchangers(NHE) (IC50=0.033μg/mL). EIPA blocks the activity of Na(+)/H(+) exchanger, which are plasma membrane proteins implicated in all forms of macropinocytosis.
||N,N-Dimethylformamide (DMF) is a polar organic solvent with a wide range of industrial applications.
||N-(2-Acetamido)-2-Iminodiacetic acid (ADA buffer) is a biological buffer component and can be used as a pharmaceutical intermediate.
N-(3-Methoxybenzyl) Palmitamide is a promising inhibitor of <b>FAAH</b> for the treatment of pain, inflammation and CNS degenerative disorders.
N- (3-Methoxybenzyl-(9z,12z)-octadecadienamide is the impurity of Macamide.
||N-(5-Aminopentyl)acetamide (Monoacetylcadaverine, N-Acetylcadaverine) is the acetylated form of the polyamine cadaverine, which is a foul-smelling diamine compound.
||N-(beta-ketocaproyl)-L-Homoserine lactone (N-(Ketocaproyl)-L-homoserine lactone, N-(β-Ketocaproyl)-L-hoMoserine lactone) is an autoinducer of P. fischeri luciferase and a component of quorum regulatory sensing.
||N-(Hydroxymethyl)nicotinamide (Nikomethamide, Bilamid, N-hydroxymethylnicotinamide) is an antimicrobial agent.
||N-(p-Coumaroyl) Serotonin (p-coumaroylserotonin) is a polyphenol isolated from the seeds of safflower and has antioxidative, anti-atherogenic and anti-inflammatory properties, can inhibits PDGF-induced on phosphorylation of PDGF receptor and Ca2+ release from sarcoplasmic reticulum.
N-Acetyl-5-hydroxytryptamine (NAS, N-Acetylserotonin, Normelatonin, O-Demethylmelatonin), a precursor of melatonin, is a potent and selective agonist of TrkB receptor.
N-Acetyl-D-galactosamine (D-N-Acetylgalactosamine) is an endogenous metabolite.
N-Acetyl-D-mannosamine (ManNAc, N-acetyl-beta-mannosamine), a precursor of a sialic acid, improves the age-dependent attenuation of synaptic transmission and long-term potentiation (LTP). N-Acetyl-D-mannosamine treatment is a potential therapeutic application for cognitive dysfunction.
N-Acetyl-DL-methionine is an active endogenous metabolite that decreases the hepatic glutathione level in male Bom:NMRI mice.
N-Acetyl-L-alanine (NAAL, Ac-Ala-OH) is an active endogenous metabolite.
N-Acetyl-L-arginine (Ac-Arg-OH) dihydrate is an endogenous metabolite.
N-acetyl-L-leucine is an active endogenous metabolite that accelerates vestibular compensation after unilateral labyrinthectomy by action in the cerebellum and thalamus.
||N-Acetyl-L-methionine (Ac-Met-OH) is an L-methionine derivative that is nutritionally and metabolically equivalent to L-methionine. It is a superior ROS scavenger.
||N-Acetyl-L-phenylalanine is a hazardous amphipathic metabolite of phenylalanine.
||N-Acetyl-L-tyrosine is an acetylated form of the amino acid, L-Tyrosine. It is involved in catecholamine production.
||N-acetylcysteine amide is a membrane penetrating antioxidant with anti-inflamatory activity through regulation of activation of NF-κB and HIF-1α as well as modulation of ROS.
||N-Acetylglucosamine (GlcNAc) is a monosaccharide that usually polymerizes linearly through (1,4)-β-linkages. It may be helpful for the treatment of autoimmune diseases.
||N-Acetylglutamic acid (N-Acetylglutamate) is the first intermediate involved in the biosynthesis of arginine in prokaryotes and simple eukaryotes and a regulator in the process known as the urea cycle that converts toxic ammonia to urea for excretion from the body in vertebrates.
N-Acetylglycine (NAGly, Aceturic acid, Acetamidoacetic acid), a minor constituent of numerous foods, is not genotoxic or acutely toxic.
||N-Acetylneuraminic acid (Neu5Ac, NeuAc, Acido aceneuramico, Acide aceneuramique, Acidium aceneuramicum, Sialic acid, NANA) is the predominant sialic acid found in mammalian cells. Sialic acids are negatively charged monosaccharides attached to the end of sugar chains, giving rise to a wide variety of glycoproteins and glycolipids in biological fluids and cell membranes.
||N-Acetylornithine is an intermediate in the enzymatic biosynthesis of the amino acid L-arginine from L-glutamate. It is a minor component of deproteinized blood plasma of human blood.
||N-Acetylprocainamide (Acecainide, NAPA, ASL 601) hydrochloride is a class III antiarrhythmic compound, which blocks K+ channels. It can be given either intravenously or orally, and is eliminated primarily by renal excretion.
||N-Benzoyl-(2R,3S)-3-phenylisoserine， also known as taxol side chain, is important for strong antitumor activity of taxol.
N-Benzylpalmitamide is a macamide isolated from Lepidium meyenii, acts as an inhibitor of fatty acid amide hydrolase (FAAH).
N-benzylpentadecanamide is a member of the N-benzylamides series derived from Maca (<i>Lepidium meyenii</i>).
N-Benzylstearamide (N-Benzyloctadecanamide) is a macamide, a distinct class of secondary metabolites in Lepidium meyenii Walp. (Maca).
||N-Boc-4-pentyne-1-amine is a PROTAC linker that refers to the alkyl chain composition. N-Boc-4-pentyne-1-amine is applicable to the synthesis of the PROTAC MG-277.
||N-Boc-diethanolamine is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
||N-Boc-PEG2-bromide is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
||N-Boc-PEG4-bromide is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
||N-Boc-PEG5-alcohol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||N-Boc-PEG8-alcohol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||N-Boc-serinol is an alkyl/ether-based PROTAC linker that is applicable to the synthesis of PROTACs.
||N-Butyryl-L-homoserine lactone (N-Butanoyl-L-homoserine lactone, N-Butyrylhomoserine lactone, C4-HSL) is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). N-Butyryl-L-homoserine lactone is a small diffusible signaling molecule involved in quorum sensing, controlling gene expression, and cellular metabolism.
N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN, OH-BBN) is a model compound that induces high-grade, invasive tumors in the urinary bladder.
||n-Butylidenephthalide ((Z)-Butylidenephthalide, 3-Butylidenephthalide, Butylidenephthalide), isolated from the chloroform extract of Angelica sinensis (AS-C), contributes to a range of biological activities, including diminution of angina, platelet aggregation, proliferation, non-specific spasmosis.
||N-Caffeoyl O-methyltyramine is a class of alkaloid isolated from Cuscuta reflexa with strong inhibitory activity against α-glucosidase with IC50 of 103.58 μM.
||N-desMethyl EnzalutaMide (N-desmethyl MDV 3100) is the active metabolite of Enzalutamide. N-desmethyl Enzalutamide demonstrates primary and secondary pharmacodynamics of similar potency to Enzalutamide and circulates at approximately the same plasma concentrations as enzalutamide.
||N-Desmethylclozapine (Norclozapine, Normethylclozapine), a metabolite of the atypical antipsychotic drug Clozapine, is a potent, allosteric and partial agonist of M1 receptors with EC50 of 115 nM. N-Desmethylclozapine is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation and also a δ-opioid agonist.
||N-Desmethyltamoxifen, the major metabolite of Tamoxifen in humans and a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen, also is a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation.
||N-Desmethyltamoxifen hydrochloride (N-Desmethyl tamoxifen HCl), the primary metabolite of tamoxifen, is an estrogen response modifer and protein kinase C inhibitor with IC50 of 25 µM.
||N-Ethyl-N-(2-hydroxy-3-sulfopropyl)-3-toluidine (TOOS) is a chromogenic agent used for catalase spectrophotometric determination.
||N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It is an irreversible inhibitor of all cysteine peptidases, with alkylation occurring at the active site thiol group. N-Ethylmaleimide (NEM) inactivates endogenous deubiquitinating enzymes (DUBs). N-Ethylmaleimide (NEM) specifically inhibits phosphate transport in mitochondria.
N-Feruloyloctopamine, an antioxidant constituent, significantly decreases the phosphorylation levels of Akt and p38 MAPK.
N-Feruloylserotonin ((E/Z)-Moschamine), an antioxidative component and bioactive serotonin derivative, from the Seed of <i>Carthamus tinctorius</i> L., ameliorates atherosclerosis and distensibility of the aortic wall in Kurosawa and Kusanagi-hypercholesterolemic (KHC) rabbits.
N-Formyl-L-methionine (For-Met-OH) is an endogenous metabolite.
N-Formylcytisine is a cytisine-type alkaloid from the stem bark of Maackia amurensis.
N-Formylglycine (2-formamidoacetic acid, For-Gly-OH, FGly) is an endogenous metabolite.
||N-hexanoyl-L-Homoserine lactone (C6-HSL) is a small diffusible signaling molecule which is involved in quorum sensing, controlling gene expression, and affecting cellular metabolism.
||N-Hydroxysulfosuccinimide sodium is a non-cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
||N-Isovaleroylglycine is an acyl glycine that is normally minor metabolites of fatty acids.
||N-Methylhydantoin (1-Methylhydantoin, Dioxy-creatinine) is a small molecular weight polar substance, the product of degradation of creatinine by bacteria. It is an unexpected metabolite of the intelligence-affecting substance dupracetam.
N-Methylnicotinamide (MNA, Nicotinyl Methylamide, N-Methyl-3-pyridinecarboxamide) is an active endogenous metabolite that improves endothelial dysfunction and attenuates atherogenesis via the modulation of ADMA-DDAH axis.
||N-Methylnuciferine is an alkaloid isolated from Lotus Plumule that ameliorates lipopolysaccharide-induced depression-like behavior.
||N-Methylsarcosine (N,N-Dimethylglycine, (Dimethylamino)acetic acid) is a natural N-methylated glycine that is used in the development of glycine-based ionic liquids and emulsifiers.
N-Nitroso-N-methylurea (NMU, MNU, NMH, 1-Methyl-1-nitrosourea, N-Methyl-Nnitrosourea, Methylnitrosourea) is a highly reliable carcinogen, mutagen, and teratogen.
N-Nitrosodiethylamine (N-Nitroso-diethylamine, NDEA, diethylnitrosamine, DEN) is DNA reactive after bioactivation and produces tumors in many animal species.
N-Nornuciferine is an aporphine alkaloid in lotus leaf that significantly inhibits CYP2D6.
N-p-trans-Coumaroyltyramine is an alpha-glucosidase inhibitor.
||N-piperidine Ibrutinib hydrochloride
||N-piperidine Ibrutinib hydrochloride, a reversible Ibrutinib derivative, is a potent BTK inhibitor with IC50s of 51.0 and 30.7 nM for WT BTK and C481S BTK, respectively.
||N-Succinimidyl-S-acetylthioacetate (SATA) is a protein modification agent which introduces thiol-groups into protein molecules. N-Succinimidyl-S-acetylthioacetate (SATA) adds sulfhydryl groups to proteins and other amine-containing molecules in a protected form.
||N-Sulfo-glucosamine sodium salt
||N-Sulfo-glucosamine sodium salt (N-sulfoglucosamine sodium salt) is a member of the class of compounds known as hexoses that is soluble (in water) and an extremely strong acidic compound. It locates in the cytoplasm within the cells.
N-trans-Feruloyltyramine (Moupinamide), an alkaloid from Piper nigru, is an inhibitor of COX1 and COX2 with potential antioxidant properties, and possesses anti-inflammatory activity.
||N-Vanillyldecanamide is a capsaicinoid isolated from the fruits of Capsicum annuum, which can significantly reduce the radical length of Lactuca sativa seedling in a dose-dependent manner.
N-Benzyllinolenamide is a natural macamide isolated from <i>Lepidium meyenii</i>, acts as an inhibitor of <b>fatty acid amide hydrolase (FAAH)</b> with an IC<sup>50</sup> of 41.8 μM.
||N3-PEG2-C2-NHS ester is a noncleavable 2-unit PEG linker applied into the synthesis of antibody-drug conjugates (ADCs).
||N3-PEG3-CH2CH2-Boc is a cleavable 3-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). N3-PEG3-CH2CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be applied into the synthesis of PROTACs.
||N3-Ph-NHS ester is a non-cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
||N6-methyladenosine (m6A, NSC-29409, 6-Methyladenosine, N-Methyladenosine) is a base modified analog of adenosine and is found as a minor nucleoside in natural RNAs.
||N6022 is a selective, and reversible inhibitor of S-nitrosoglutathione reductase (GSNOR) with IC50 of 8 nM and Ki of 2.5 nM. Phase 1/2.
||Nabumetone (BRL-14777) is a non-steroidal anti-inflammatory drug and its active metabolite inhibits the COX.
||NAcM-OPT is a specific, reversible and orally bioavailable inhibitor of cullin neddylation 1 (DCN1) that targets N-Acetyl-UBE2M (E2 conjugating enzyme, UBC12) interaction with DCN1 with IC50 of 79 nM.
||NAD+ (β-DPN, β-NAD, β-Nicotinamide Adenine Dinucleotide) is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.
||NADH Disodium Salt Hydrate
||NADH is a coenzyme that functions as a regenerating electron donor in catabolic processes including glycolysis, β-oxidation and the citric acid cycle.
||Nadifloxacin (OPC-7251) is a topical fluoroquinolone antibiotic for the treatment of acne vulgaris.
||Nadolol (Corgard, Solgol, Anabet, SQ11725) is a non-selective beta-adrenergic antagonist with antihypertensive and antiarrhythmic activities.
||Nafamostat mesilate (FUT-175)
||Nafamostat mesilate (FUT-175) is a synthetic serine protease inhibitor, used as an anticoagulant during hemodialysis. Nafamostat mesylate blocks activation of SARS-CoV-2 and is investigated as a new treatment option for COVID-19. Nafamostat Mesilate attenuates inflammation and apoptosis.
||Nafarelin Acetate is a Gonadotropin-releasing hormone (GnRH) agonist; synthetic decapeptide analog of GnRH (luteinizing hormone-releasing hormone, gonadorelin); structurally related to goserelin, leuprolide, and triptorelin.
||Nafcillin sodium (CL 8491) reversibly inhibits β-lactamase with Kd of 33 mM.
||Nafronyl oxalate salt
||Nafronyl oxalate salt is the oxalate salt form of nafronyl, which is a selective antagonist of 5-HT2 receptors and a vasodilator used in the management of peripheral and cerebral vascular disorders.
||Naftifine is an allylamine antifungal drug for the topical treatment of tinea pedis, tinea cruris, and tinea corporis, probably involves selectively blocking sterol biosynthesis via inhibition of the squalene 2,3-epoxidase enzyme.
||Naftopidil (KT-611) is a selective α1-adrenergic receptor antagonist with Ki of 3.7 nM, 20 nM, and 1.2 nM for α1a, α1b, and α1d, respectively, used for the treatment of benign prostatic hyperplasia.
||Naftopidil DiHCl (KT-611) is a selective 5-HT1A and α1-adrenergic receptor antagonist with IC50 of 0.1 μM and 0.2 μM, respectively.
||Nalidixic acid (NSC-82174) is a synthetic 1,8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial DNA gyrase.
||Naloxone HCl is an opioid inverse agonist drug used to counter the effects of opiate overdose.
||Naltrexone HCl is an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence.
||Namodenoson (CF-102, 2-Cl-IB-MECA) is an orally bioavailable and selective agonist of the A3 adenosine receptor (A3AR) with Ki of 0.33 nM. Namodenoson exerts an anti‑NASH effect mediated via the de‑regulation of the PI3K/NF‑κB/Wnt/β‑catenin signaling pathway.
||Nanchangmycin is a polyether antibiotic with similar structure to dianemycin and is very active against a broad spectrum of harmful nematodes and insects but not for mammals and plants.
||Nanofin (2,6-Dimethylpiperidine, Lupetidine, Naniopinum) is a ganglion blocker alkaloid having nicotinic acetylcholine receptor antagonist action. It has antihypertensive effect used for mild to moderate hypertension.
||Nanvuranlat (JPH203, KYT-0353, JPH-203SBECD), a selective L-type amino acid transporter 1 inhibitor, shows a dramatic inhibition of leucine uptake (IC50=0.06 µM) and cell growth (IC50=4.1 µM) in human colon cancer cells (HT-29), human oral cancer cells (YD-38) and leukemic cells.
||Napabucasin (BBI608) is an orally available Stat3 and cancer cell stemness inhibitor.
||Naphazoline HCl is an ocular vasoconstrictor and imidazoline derivative sympathomimetic amine.
||Naporafenib (LXH254) is a type II ATP-competitive inhibitor that inhibits both B- and CRAF kinase activities at picomolar concentrations with a high degree of selectivity against a panel of 456 human kinases and in cell-based assays.
||Naproxen is an anti-inflammatory agent with analgesic and antipyretic properties. It is a nonselective inhibitor of COX-1 and COX-2.
||Naproxen Sodium (RS-3650) is a COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively.
||Naquotinib (ASP8273) is an orally available, irreversible, mutant-selective, epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity.
||Naratriptan HCl is a triptan agent that is used for the treatment of migraine headaches.
||Narciclasine (Lycoricidinol), an isocarbostyril alkaloid narciclasine, targets STAT3 via distinct mechanisms in tamoxifen-resistant breast cancer cells. Narciclasine suppresses phosphorylation, activation, dimerization, and nuclear translocation of STAT3 by directly binding with the STAT3 SH2 domain and leads STAT3 degradation. Narciclasine is a plant growth modulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner.
||Nardostachyos Rhizoma Extract
||Naringenin (NSC 34875, S-Dihydrogenistein, NSC 11855, Salipurol) is a natural predominant flavanone derived from plant food, which is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator.
||Naringenin chalcone (Chalconaringenin, Isosalipurpol, trans-2'4'6'4-tetrahydroxychalcone) is the main active component of tomato skin extract, has been proposed as an antioxidant, an anti-inflammatory, and a regulator of fat and sex hormone metabolism.
Naringenin triacetate is a flavonoid isolated from plant, exhibits a good binding affinity with multiple crystal structures of first bromodomain BRD4 (BRD4 BD1).
||Naringin (Naringoside) is a flavanone glycoside, which exerts a variety of pharmacological effects such as antioxidant activity, blood lipid lowering, anticancer activity, and inhibition of cytochrome P450 enzymes.
||Naringin Dihydrochalcone(Naringin DC) is a new-style sweetening agent and an artificial sweetener derived from naringin and also an inhibitor of CYP enzymes.
||Narirutin (Naringenin-7-O-rutinoside, Isonaringin), a flavanone abundant in citrus fruits, possesses anti-inflammatory and anti-oxidative effects.
||Nastorazepide (Z-360), a cholecystokinin-2/gastrin receptor (CCK2/gastrin receptor) antagonist, combines with gemcitabine prolonged survival and reduces gemcitabine-induced vascular endothelial growth factor (VEGF) expression in a pancreatic carcinoma orthotopic xenograft mouse.
||Natamycin (Pimaricin), a natural and versatile anti-fungal agent during fermentation by the bacterium Streptomyces natalensis, commonly found in soil; with little to no flavour interference
||Nateglinide (A-4166) is an insulin secretagog agent that lowers blood glucose levels by stimulating insulin secretion from the pancreas.
||Natural indigo Extract
||Natural Organic Compound Library
||A unique collection of 1106 plant-derived natural organic compounds used for high throughput screening(HTS) and high content screening(HCS).
||Natural Product Library
||A unique collection of 2659 natural products for high throughput screening (HTS) and high content screening (HCS).
||NAV-2729, an inhibitor of Arf6 activation which directly binds to Arf6, also inhibits all Arf guanine nucleotide exchange factors (ArfGEFs) with a strongest effect against BRAG2 and Arf1 .
||Navarixin (SCH-527123, MK-7123, PS-291822) is a potent, orally bioavailable CXCR2/CXCR1 antagonist with IC50 values of 2.6 nM and 36 nM, respectively.
||Navitoclax (ABT-263) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ≤ 0.5 nM, ≤1 nM and ≤1 nM in cell-free assays, but binds more weakly to Mcl-1 and A1. Phase 2.
||Navoximod (GDC-0919, NLG-919) is a potent inhibitor of IDO (indoleamine-(2,3)-dioxygenase) pathway with Ki of 7 nM and EC50 of 75 nM.
||Nazartinib (EGF816, NVS-816) is a covalent, irreversible, mutant-selective EGFR inhibitor that has nanomolar inhibitory potency against activating mt (L858R, ex19del) and T790M mt, with up to 60-fold selectivity over wild type (wt) EGFR in vitro.
||NB-598 is a potent, competitive squalene epoxidase (SE) inhibitor. NB-598 suppresses cholesterol biosynthesis.
||NBD-556 is a novel human immunodeficiency virus type 1 (HIV-1) entry inhibitor that block the gp120-CD4 interaction.
||NBQX (FG9202, NNC 079202) is a highly selective and competitive antagonist of AMPA receptor (AMPAR) with anti-epileptic effect.
||NCB-0846 is a novel, orally small-molecule Wnt inhibitor that inhibits TNIK (TRAF2 and NCK-Interacting Kinase, MAP4K7) with an IC50 value of 21 nM.
||NCC007 is a novel dual inhibitor of CKIα and CKIδwith IC50 of 1.8 μM and 3.6 μM, respectively.
NCGC00244536 is a novel KDM4 Inhibitor with an IC50 of ∼10 nM.
||NCGC00262650 is a dual inhibitor of AMA1-RON2 interaction and c-Src tyrosine kinase activity.
||NCGC00378430 is an inhibitor of the SIX1/EYA2 complex that significantly suppresses breast cancer-associated metastasis in vivo without significantly altering primary tumor growth.
||NCGC607 is a a noninhibitory chaperone of glucocerebrosidase (GCase).
||NCT-503 is a phosphoglycerate dehydrogenase (PHGDH) inhibitor with the IC50 value of 2.5 μM. It is inactive against a panel of other dehydrogenases and shows minimal cross-reactivity in a panel of 168 GPCRs.
||ND-646 is an allosteric inhibitor of the ACC (Acetyl-coA carboxylase) enzymes that prevents ACC subunit dimerization to suppress fatty acid synthesis with IC50 of 3.5 nM and 4.1 nM for hACC1 and hACC2, respectively.
||NDI-091143 is a potent inhibitor of human ATP-citrate lyase(ACLY) with a Ki of 7.0 nM and an IC50 of 2.1 nM in the ADP-Glo assay.
||NDMC101 inhibits osteoclastogenesis which also ameliorates paw swelling and inflammatory bone destruction, associating with the inhibition of such transcription factors as NF-κB and NFATc1 as well as multiple protein kinases, including p38, ERK, and JNK.
||NE 52-QQ57 is a selective, and orally available antagonist of G-protein coupled receptor 4 (GPR4) with IC50 of 0.07 μM. NE 52-QQ57 effectively blocks GPR4-mediated cAMP accumulation with IC50 of 26.8 nM in HEK293 cells. The antagonism of GPR4 with NE 52-QQ57 significantly inhibits the AGE-induced increased expression of several key inflammatory cytokines and signaling molecules, including tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, inducible nitric oxide synthase (iNOS), nitric oxide (NO), cyclooxygenase 2 (COX2), and prostaglandin E2 (PGE2).
||Nebivolol (Bystolic) is a β1 receptor blocker with nitric oxide-potentiating vasodilatory effect used in treatment of hypertension and also for left ventricular failure.
||Nebivolol hydrochloride (R-65824)
||Nebivolol HCl (R-65824) selectively inhibits β1-adrenoceptor with IC50 of 0.8 nM.
||Necrostatin 2 racemate (Nec-1s)
||Necrostatin 2 racemate (Nec-1s, 7-Cl-O-Nec1, Necrostatin-1 stable, Necrostatin 1S) is a stable variant of Necrostatin-1. It is a more specific RIPK1 inhibitor lacking the IDO-targeting effect, with >1000-fold more selective for RIPK1 than for any other kinase out of 485 human kinases.
||Necrostatin-1 (Nec-1) is a specific RIP1 (RIPK1) inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM in 293T cells. Necrostatin-1 also blocks IDO and suppresses autophagy and apoptosis.
||Necrostatin-34 (Nec-34) is a small molecule inhibitor of RIPK1 kinase with an IC50 of 0.13 μM in L929 cells.
||Necrosulfonamide is a very specific and potent necrosis inhibitor and blocks mixed lineage kinase domain-like protein (MLKL).
||Nedaplatin is a derivative of cisplatin and DNA damage agent for tumor colony forming units with IC50 of 94 μM.
||NEDD8 inhibitor M22
||NEDD8 inhibitor M22 (NAE-IN-M22) is a novel selective NEDD8 activating enzyme (NAE) inhibitor with GI50 of 5.5 μM in A549 cells.
||Nedisertib (M3814, Peposertib, MSC2490484A) is an orally bioavailable, highly potent and selective inhibitor of DNA activated protein kinase (DNA-PK) with IC50 of < 3 nM.
||Nefazodone hydrochloride (BMY-13754-1) is the hydrochloride salt form of nefazodone, which is an atypical antidepressant showing antagonistic activity on serotonin reuptake.
||Neferine ((R)-1,2-Dimethoxyaporphine), a natural component of Nelumbo nucifera, has antitumor efficiency. Neferine induces apoptosis in renal cancer cells. Neferine prevents autophagy through activation of Akt/mTOR pathway and Nrf2 in muscle cells. Neferine strongly inhibits NF-κB activation. Neferine possesses a number of therapeutic effects such as anti-diabetic, anti-aging, anti-microbial, anti-thrombotic, anti-arrhythmic, anti-inflammatory and even anti-HIV.
||Nefiracetam (DZL 221) is a GABAergic, cholinergic, and monoaminergic neuronal system enhancer for Ro 5-4864-induced convulsions. Phase 2.
||Neflamapimod (VX-745) is a potent and selective inhibitor of p38α with IC50 of 10 nM, 22-fold greater selectivity versus p38β and no inhibition to p38γ.
||Nefopam HCl is a centrally-acting but non-opioid analgesic drug by blocking voltage-gated sodium channel and inhibition of serotonin, dopamine and noradrenaline reuptake.
||Nelarabine (506U78) is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells.
||Nelfinavir (AG 1343) Mesylate
||Nelfinavir Mesylate (Viracept, AG1343) is a potent HIV protease inhibitor with Ki of 2 nM.
||Nelumbinis Folium Extract
||Nemiralisib, also known as GSK-2269557, is a potent and selective PI3Kδ inhibitor(pKi = 9.9).
||Nemtabrutinib (ARQ 531)
||Nemtabrutinib (ARQ 531, MK-1026) is an ATP-competitive tyrosine kinase inhibitor designed to target BTK with an IC50 of 0.85 nM. It also has a distinct kinase selectivity profile with strong inhibitory activity against several key oncogenic drivers from TEC, Trk and Src family kinases.
||NEO2734 (EP31670) is a novel, orally active and selective dual inhibitor of p300/CBP and BET bromodomain with IC50 of both <30 nM.
Neoanhydropodophyllol is a cyclolignan derivative, with antineoplastic activity. Neoanhydropodophyllol displays cytotoxicity against several cancer cells (leukemia, lung carcinoma and colon carcinoma).
Neochamaejasmin B, the abundant components in the dried roots of <i>Stellera chamaejasme</i> L., has pharmacological activities.
||Neochlorogenic acid (Neochlorogenate, 5-O-Caffeoylquinic acid) is a natural polyphenolic compound found in some types of dried fruits and a variety of other plant sources such as peaches. It shows antioxidant, antibacterial, antiviral, and antipyretic activities and exerts neuroprotective effects through the inhibition of pro-inflammatory pathways in activated microglia.
||Neocindilide (Sedanolide), a natural compound found in edible umbelliferous plants, exhibits anti-inflammatory and antioxidant activities.
||Neocryptotanshinone, a fatty diterpenoid from Salvia miltiorrhiza, inhibits lipopolysaccharide-induced inflammation by suppression of NF-κB and iNOS signaling pathways.
||Neodiosmin (Diosmetin-7-neohesperidoside, Diosmetin-7-O-neohesperidoside), a flavone glycoside isolated from C. aurantium, is a strong antioxidant with potential applications in foods, beverages, and pharmaceutical preparations.
||Neoeriocitrin, isolated from Drynaria Rhizome, shows activity on proliferation and osteogenic differentiation in MC3T3-E1, also is a potent acetylcholinesterase (AChE) inhibitor.
||Neohesperidin (NSC 31048), a flavanone glycoside found in citrus fruits, is an antioxidant agent.
||Neohesperidin Dihydrochalcone (Nhdc)
||Neohesperidin dihydrochalcone(Nhdc, NCI-c60764), sometimes abbreviated to neohesperidin DC or simply NHDC, is an artificial sweetener derived from citrus.
||Neohesperidose is a disaccharide isolated from species of typha.
Neolancerin is a natural product with weak cytotoxic activity against HL-60 cells.
Neoliquiritin is isolated from <i>Glycyrrhiza uralensis</i> with an anti-inflammatory activity.
||Neomangiferin (Mangiferin 7-glucoside), a natural xanthone C-glycoside mainly obtained from the well-known traditional Chinese medicine rhizoma of Anemarrhena asphodeloides, exhibits antidiabetic activity and antiosteoporotic action.
||Neomycin sulfate is an aminoglycoside antibiotic, used to treat bacteria infections.
||Neoruscogenin, a natural sapogenin isolated from R. rhizoma, is a potent and high-affinity agonist of RAR-related orphan receptor alpha (RORα or nuclear receptor NR1F1).
||Neostigmine Bromide is a reversible acetylcholinesterase inhibitor.
||Neotame is a low-caloric and high-intensity artificial sweetener that reduces the alpha-diversity and altered the beta-diversity of the gut microbiome.
Neotriptophenolide is a sesquiterpene pyridine alkaloid isolated from the root barks of Tripterygium hypoglaucum.
||Neotuberostemonine (NTS), one of the main antitussive alkaloids in the root of Stemona tuberosa Lour, has a significant effect on BLM-induced pulmonary fibrosis by inhibiting macrophage recruitment and M2 polarization protective effect.
||Nepafenac (AHR 9434, AL 6515) is a prodrug of amfenac that acts as an inhibitor of COX-1 and COX-2 activity, used in the treatment of pain and inflammation associated with cataract surgery.
||Nepicastat (SYN-117) HCl
||Nepicastat (SYN-117) HCl is a potent and selective inhibitor of both bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors. Phase 2.
Nepodin is a natural product isolate from Rumex crispus, which is a quinone oxidoreductase (PfNDH2) inhibitor, also has antidiabetic and antimalarial activities.
||Nepsilon-Acetyl-L-lysine is an R-chain N-acetylated α amino acid used together with other lysine analogues to differentiate and characterized various aminoacylases and regulator 2 (Sir2) enzymes/sirtuins.
||Nequinate, a quinoline compound, is an anticoccidial agent against cecal coccidiosis (Eimeria tenella) infections, also inhibits xanthine oxidoreductase (XOD) activity.
||Neratinib (HKI-272) is a highly selective HER2 and EGFR inhibitor with IC50 of 59 nM and 92 nM in cell-free assays; weakly inhibits KDR and Src, no significant inhibition to Akt, CDK1/2/4, IKK-2, MK-2, PDK1, c-Raf and c-Met. Phase 3.
||Nerium oleander Extract
||Nerol (Cis-Geraniol, Neryl alcohol) is a monoterpene found in many essential oils such as lemongrass and hops. Nerol has antifungal activity, Nerol can trigger mitochondrial dysfunction and disruption via elevation of Ca2+ and ROS leading to apoptosis.
||Nerolidol (Peruviol) is a naturally occurring sesquiterpene found in the essential oils of many types of plants and flowers. It has diverse range of pharmacological and biological activities including antioxidant, anti-microbial, anti-biofilm, anti-parasitic, insecticidal, anti-ulcer, skin penetration enhancer, anti-tumor, anti-nociceptive and anti-inflammatory properties.
||Nervonic acid (cis-15-Tetracosenoic acid) is a long chain unsaturated fatty acid that is enriched in sphingomyelin and may enhance the brain functions and prevent demyelination.
||Neryl acetate (Nerol, Acetic acid neryl ester, cis-Geranyl), a chemical compound found in citrus oils, is a flavouring agent.
Nesiritide (Brain Natriuretic Peptide-32 human; BNP-32) is an agonist of natriuretic peptide receptors (NPRs).
||Nesolicaftor (PTI-428) is a specific cystic fibrosis transmembrane conductance regulator (CFTR) amplifier that increases CFTR expression.
||Netarsudil (AR-13324) 2HCl
||Netarsudil (a.k.a. AR-13324) is ROCK inhibitor with Ki value of 0.2-10.3 nM. It is currently in clinical trials for the treatment of glaucoma and ocular hypertension.
||Neticonazole (SS717) is a selecvie inhibitor of exosome biogenesis and secretion. Neticonazole exhibits Neticonazole antifungal and antitumor activity.
||Neticonazole is an imidazole antifungal for the treatment of fungal skin infections.
||Netilmicin Sulfate is a member of the aminoglycoside family of antibiotics.
||Netupitant (CID6451149) is a selective neurokinin 1 (NK1) receptor antagonist with potential antiemetic activity.
||Neuronal Signaling Compound Library
||A unique collection of 1370 small molecule compounds with biological activity used for neurologic research and associated assays
||Neuropeptide Y (human, rat)
Neuropeptide Y (human, rat) is involved in Alzheimer's disease (AD) and protects rat cortical neurons against β-Amyloid toxicity.
||Neutral Red Solution
||Neutral Red Solution, a nitrogenous pH-indicator, is an indicator for the internal acidification of thylakoids, which can stain lysosomes red.
Nevadensin is a naturally occurring selective inhibitor of <b>human carboxylesterase 1 (hCE1)</b> with an IC50 of 2.64 μM. Nevadensin has a variety of pharmacological effects such as anti-mycobacterium tuberculosis activities, antitussive, anti-inflammatory and anti-hypertensive.
||Nevirapine (NSC 641530)
||Nevirapine (NSC 641530) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS.
||NEXIUM (esomeprazole magnesium)
||Esomeprazole Magnesium is a proton pump inhibitor to reduce gastric acid secretion through inhibition of H(+)/K(+)-ATPase in gastric parietal cells.
||NF-56-EJ40 is a potent, high-affinity, and highly selective human SUCNR1 (GPR91) antagonist with an IC50 of 25 nM and a Ki of 33 nM, has high affinity for humanized rat SUCNR1 with a Ki value of 17.4 nM.
||NF-κB Signaling Compound Library
||A unique collection of 428 small molecules used for NF-κB signaling pathway research which plays a key role in immunology/inflammation and cancer.
||NF-κB-IN-1 is a potent NF-κB signaling pathway inhibitor, which acts by directly inhibiting inhibitory κB kinase (IKK).
||NG-52 is a tri-substituted purine that binds to the ATP-binding site of yeast cyclin-dependent kinases, inhibiting Cdc28p and Pho85p with IC50s of 7 and 2 μM, respectively.
||NG25 is a novel inhibitor of TAK1 with enzymatic IC50s of 149 and 21.7 nM for TAK1 and MAP4K2 respectively.
||NGI-1 (ML414) is an aminobenzamide-sulfonamide compound that targets both oligosaccharyltransferase (OST) isoforms and therefore may exhibit antiviral activity against flaviviruses.
||NGP 555 is a small-molecule modulator of γ-secretase and has been successful in achieving good oral absorption, brain penetration, CNS activity, and specificity for a lipid-based membrane target preclinically.
||NH-bis(C1-Boc) is an uncleavable linker that can be used for antibody-drug conjugates (ADCs).
||NH2-C2-NH-Boc is a alkyl chain-based PROTAC linker that is applicable to the synthesis of PROTACs.
||NH2-C4-NH-Boc is a PROTAC linker that refers to the Alkyl/ether composition. NH2-C4-NH-Boc can be applicable to the synthesis of a series of PROTACs.
||NH2-PEG1-CH2CH2-Boc is a PEG- and Alkyl/ether-based PROTAC linker that is applicable to the synthesis of PROTACs.
||NH2-PEG2-C2-Boc is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. NH2-PEG2-C2-Boc is a non-cleavable 2-unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
||NH2-PEG3 is a PROTAC linker that belongs to a polyethylene glycol (PEG) linker. NH2-PEG3 is applicable to the synthesis of the PROTAC (β-NF-JQ1).
||NH2-PEG3-C1-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||NH2-PEG3-C2-Boc (PROTAC Linker 15) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
||NH2-PEG4-CH2CH2COOH is a cleavable 4-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
||NH2-PEG5-OH is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. NH2-PEG5-OH is also a non-cleavable 5-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
||NH2-PEG6-Boc is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. NH2-PEG6-Boc is also a non-cleavable 6-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
||NH2-PEG7 is a PROTAC linker that refers to the PEG composition. NH2-PEG7 is applicable to the synthesis of the PROTAC PARP1 degrader iRucaparib-AP6.
||NHPI-PEG4-C2-NHS ester is used as a linker for antibody-drug conjugates (ADCs).
NHWD-870 is a potent, orally active and selective BET family bromodomain inhibitor and only binds bromodomains of BRD2, BRD3, BRD4 (IC50=2.7 nM), and BRDT. NHWD-870 has potent tumor suppressive efficacies and suppresses cancer cell-macrophage interaction. NHWD-870 increases tumor apoptosis and inhibits tumor proliferation.
||NI-42 is a biased, potent inhibitor of the of the bromodomain and PHD finger-containing (BRPF) with IC50s of 7.9, 48, 260 nM for BRPF1/2/3.
||NIBR-0213 is a potent and selective antagonist of S1P(1) with efficacy in experimental autoimmune encephalomyelitis.
||NIBR-17 is a pan class I PI3K inhibitor with IC50 of 1 nM, 9.2 nM, 9 nM and 20 nM for PI3KKα, PI3KKβ, PI3KKγ and PI3KKδ, respectively .
||NIBR189 is a potent antagonist of the Epstein-Barr virus-induced gene 2 (EBI2, GPR183) receptor with IC50 of 16 nM for binding and 11 nM for function, respectively.
||Nicaraven is a hydroxyl radical scavenger with antivasospastic and neuroprotective effects.
||Nicarbazin, an effective anticoccidial, is also a wide-spectrum anti-parasitic drug.
||Nicardipine is a potent calcium channel blockader with marked vasodilator action.
||Nicardipine HCl (RS-69216) is a dihydropyridine calcium-channel blocking agent used for the treatment of vascular disorders.
||Nicergoline is an ergot derivative used to treat senile dementia and other disorders with vascular origins. It has a selective alpha-1A adrenergic receptor blocking property and also other additional mechanisms of actions.
||Niclosamide (BAY2353, Niclocide, NSC 178296) can inhibit DNA replication and inhibit STAT3 with IC50 of 0.7 μM in a cell-free assay. Niclosamide selectively inhibited the phosphorylation of STAT3 and had no obvious inhibition against the activation of other homologues (e.g., STAT1 and STAT5).
||Nicomol is a niacin derivative that exhibits antilipidemic activity.
||Nicorandil (SG-75) is a potassium channel activator, and stimulates guanylate cyclase to increase formation of cyclic GMP (cGMP).
||Nicotinamide (NSC 13128)
||Nicotinamide (NSC 13128, Niacinamide, Vitamin PP, Nicotinic acid amide, Vitamin B3, NSC 27452), a water-soluble vitamin, is an active component of coenzymes NAD and NADP, and also act as an inhibitor of sirtuins.
||Nicotinamide N-oxide (Nicotinamide 1-oxide, 1-oxynicotinamide) is recognized as an in vivo metabolite of nicotinamide which is a precurser of nicotinamide-adenine dinucleotide (NAD+) in animals. Nicotinamide N-oxide is novel, potent, and selective antagonists of the CXCR2 receptor.
||Nicotinamide Riboside Chloride
||Nicotinamide Riboside Chloride is the chloride salt form of nicotinamide riboside(NR).NR is a new form pyridine-nucleoside of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide(NAD) or NAD+ . Nicotinamide riboside chloride is a crystal form of Nicotinamide riboside (NR) chloride. Nicotinamide riboside chloride increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside chloride is used in dietary supplements.
||Nicotinic Acid is a water-soluble vitamin belonging to the vitamin B family.
||Nicotinic acid N-oxide
||Nicotinic acid N-oxide (Oxiniacic acid, Nicotinic acid 1-oxide) is nicotinic acid derivative that acts as a ligand and forms lead-carboxylate complexes having phosphorescent properties.
Nicotinuric acid (NUA) is the major detoxification product of nicotinic acid and may serve as a simple quantitative index of hepatic biotransformation of nicotinic acid.
||NiCur is a small molecule which blocks CREB-binding protein (CBP) histone acetyltransferase (HAT) activity and downregulates p53 activation upon genotoxic stress and diminishs the recruitment of p53 as well as RNA Polymerase II and levels of acetylation on histone H3 on CDKN1A promoter.
||Nidufexor (LMB763) is an agonist of farnesoid X receptor (FXR).
||Nidus Collocaliae Extract
||Nifedipine (BAY-a-1040) is a dihydropyridine calcium channel blocker, used to lower hypertension and to treat angina.
||Nifenalol (INPEA) hydrochloride is an antagonist of beta-adrenergic receptor.
||Niflumic acid is an inhibitor of cyclooxygenase-2 used for joint and muscular pain.
||Nifuratel is a nitrofuran derivative with local antiprotozoal and antifungal activity and a broad spectrum of antibacterial action.
||Nifuroxazide is a cell-permeable and orally available nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity with IC50 of 3 μM against IL-6-induced STAT3 activation in U3A cells.
||Nifurtimox (BAY-2502) is an antiprotozoal agent.
||Nigella Sativa Extract (Herb)
||Nigella Sativa Extract (Seed)
||Nigericin (NSC 292567) sodium salt
||Nigericin (NSC 292567) sodium salt is an antibiotic derived from Streptomyces hygroscopicus that works by acting as an H+, K+, and Pb2+ ionophore.Nigericin can activate NLRP3 inflammasome to induce pro-inflammatory and immunostimulatory processes.
||NIH-12848 is a specific PI5P4Kγ inhibitor with an IC50 of approximately 1 μM but does not inhibit the α and β PI5P4K isoforms at concentrations up to 100 μM.
||NIK SMI1 is a highly potent and selective NF-κB-inducing kinase (NIK) inhibitor with Ki of 0.23 nM for NIK-catalyzed hydrolysis of ATP to ADP.
||Nikethamide (Corvin, Anacardone) is a respiratory stimulant that acts directly in the respiratory centres of brain.
||Nile Red (Nile Blue A oxazone, Phenoxazone 9) is an excellent vital fluorescent stain for the detection of intracellular lipid droplets in the presence of a hydrophobic environment. Nile Red is applied for staining intracellular lipids, hydrophobic domains of proteins and lysosomal phospholipid inclusions.
||Nilotinib (AMN-107) is a selective Bcr-Abl inhibitor with IC50 less than 30 nM in Murine myeloid progenitor cells. Nilotinib induces autophagy through AMPK activition.
||Nilotinib hydrochloride (AMN-107) is the hydrochloride salt form of nilotinib, an orally bioavailable Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity.
||Nilotinib hydrochloride monohydrate
||Nilotinib (AMN-107, Tasigna) hydrochloride monohydrate is a selective and orally bioavailable inhibitor of Bcr-Abl with IC50 < 30 nM in Murine myeloid progenitor cells. Nilotinib induces autophagy through AMPK activition.
||Nilutamide (RU23908) is a nonsteroidal antiandrogen (NSAA) with affinity for androgen receptors (but not for progestogen, estrogen, or glucocorticoid receptors). It is used in the treatment of prostate cancer.
||Nilvadipine (ARC029, FR34235) is a potent calcium channel blocker with an IC50 of 0.03 nM.
Nimbolide inhibits auto-ubiquitination of the E3 ligase RNF114 and p21 ubiquitination in vitro. Nimbolide induces apoptosis through inactivation of NF-κB.
||Nimesulide is a relatively COX-2 selective inhibitor with IC50 of 26 μM.
||Nimodipine (BAY E 9736) is a dihydropyridine calcium channel blocker and an autophagy inhibitor, used in the treatment of high blood pressure.
||Nimorazole is a water soluble, 5-nitroimidazole compound with antibacterial and potential radiosensitizing activity.
||Nimustine Hydrochloride (Nidran) is the hydrochloride salt of nimustine, a nitrosourea with antineoplastic activity that alkylates and crosslinks DNA, thereby causing DNA fragmentation, inhibition of protein synthesis, and cell death.
||Ningetinib (CT-053, DE-120, CT053PTSA) is a potent, orally bioavailable inhibitor of tyrosine kinase with IC50 of 6.7 nM, 1.9 nM and <1.0 nM for c-Met, VEGFR2 and Axl, respectively. Ningetinib exhibits antitumor activity.
||Nintedanib (BIBF 1120)
||Nintedanib (BIBF 1120, Intedanib, Vargatef, Ofev) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM in cell-free assays. Phase 3.
||Nintedanib Ethanesulfonate Salt
||Nintedanib (Intedanib, BIBF 1120) is a small molecule tyrosine-kinase inhibitor with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β, respectively.
||Niraparib (MK-4827) is a selective inhibitor of PARP1/2 with IC50 of 3.8 nM/2.1 nM, with great activity in cancer cells with mutant BRCA-1 and BRCA-2. It is >330-fold selective against PARP3, V-PARP and Tank1. Niraparib can form PARP–DNA complexes resulting in DNA damage, apoptosis, and cell death. Phase 3.
||Niraparib (MK-4827) tosylate
||Niraparib tosylate (MK-4827, ZEJULA) is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM. Niraparib increases formation of PARP-DNA complexes resulting in DNA damage, apoptosis, and cell death.
Nirmatrelvir (PF-07321332) is an reversible covalent inhibitor of SARS-CoV-2 main protease (Mpro, also referred to as 3CL protease) with an ki of 3.11 nM. PF-07321332 binds directly to the catalytic cysteine (Cys145) residue of the enzyme.
||Nirogacestat (PF-03084014, PF-3084014) is a selective gamma-secretase inhibitor with IC50 of 6.2 nM in a cell-free assay. Nirogacestat (PF-03084014, PF-3084014) induces apoptosis. Phase 2.
||Nisoldipine (Sular, BAY K 5552) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM.
||Nisoxetine hydrochloride is a potent and selective noradrenaline transporter (NET) inhibitor with Kd of 0.76 nM. Nisoxetine hydrochloride is an antidepressant and local anesthetic that blocks voltage-gated sodium channels.
||Nitazoxanide (NSC 697855)
||Nitazoxanide (NTZ, NSC 697855) is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent(IC50 for canine influenza virus ranges from 0.17 to 0.21 μM). Nitazoxanide modulates autophagy and inhibits mTORC1 signaling.
||NITD-349 is an inhibitor of MmpL3 that shows highly potent anti-mycobacterial activity with MIC50 of 23 nM against virulent Mycobacterium tuberculosis H37Rv.
||Nitenpyram is a nicotinic acetylcholine receptor (AchR) agonist, used as veterinary medicine to treat parasites of livestock and pets.
||Nithiamide (CL 5279) is a non-5-nitroimidazole drugs.
||Nitisinone (NTBC, Nitisone, SC0735) is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase used in the treatment of hereditary tyrosinemia type 1.
||Nitrendipine (Bayotensin) is a dihydropyridine calcium channel blocker with an IC50 of 95 nM.
||Nitrocaramiphen hydrochloride is an antagonist of muscarinic acetylcholine receptor M1 (mAChR M1), which can completely remove the hyperpolarizing effect of muscarine.
||Nitrofural (Nitrofurazone) is a topical anti-infective agent with an IC50 of 22.83 ± 1.2 μM. (Rat LD50 = 590 mg/kg)
||Nitrofurantoin (Macrodantin, Furadantine, Furadonine) is an antibiotic used to treat bladder infections.It inhibits bacterial DNA, RNA, and cell wall protein synthesis.
||Nitroxoline (8-Hydroxy-5-nitroquinoline, 5-nitroquinolin-8-ol, 5-Nitro-8-quinolinol, 5-Nitro-8-hydroxyquinoline) is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections. Nitroxoline impairs tumor progression in vitro and in vivo by inhibiting cathepsin B activity.
||Nivolumab (anti-PD-1) is a genetically engineered, fully human immunoglobulin (Ig) G4 monoclonal antibody directed against the negative immunoregulatory human cell surface receptor programmed death-1 (PD-1,PCD-1) with immune checkpoint inhibitory and antineoplastic activities. MW : 143.597 KD.
||Nizatidine is a histamine H2 receptor antagonist with IC50 of 0.9 nM, also inhibits AChE with IC50 of 6.7 μM.
||NK01-63 (Coronastat) is a potent inhibitor of the SARS-CoV-2 3CL protease, which is a critical drug target for small molecule COVID-19, given its likely druggability and essentiality in the viral maturation and replication cycle.
||NKL 22 is a selective inhibitor of HDAC with IC50 of 78 µM.
||The mitochondrial mitoNEET ligand NL-1 is a mitoNEET inhibitor, which induces a concentration-dependent decrease in cell viability with an IC50 of 47.35 μM and 56.26 μM in REH and REH/Ara-C cells respectively. The docking studies using liver mitochondrial suspensions show the IC50 of NL-1 binding for [3H]-rosiglitazone is 0.9 μM and the Ki for NL-1 site 1 and site 2 was 4.78 and 2.77, respectively.
||NLRP3 Inflammasome Inhibitor I
||NLRP3 Inflammasome Inhibitor I, an intermediate substrate in the synthesis of glyburide which is free of the cyclohexylurea moiety involved in insulin release, is a novel inhibitor of the NLRP3 inflammasome.
||NLX-101 (F-15599) is a highly selective 5-HT1A receptor biased agonist that mediates antidepressant-like activity in rats via prefrontal cortex 5-HT 1A receptors.
||NLX-204 is a potent, selective agonist of ERK1/2 phosphorylation-preferring serotonin 5 HT1A receptor with pKi of 10.19.
||NMDA (N-Methyl-D-aspartic acid)
||NMDA（N-Methyl-D-aspartic acid）is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. Phase 4.
||NMDAR antagonist 1
||NMDAR antagonist 1 is a potent and orally bioavailable NR2B-selective antagonist of NMDAR.
||NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.
||NMS-P118 is a potent, orally available, and highly selective PARP-1 inhibitor endowed with excellent ADME and pharmacokinetic profiles, showing 150-fold selectivity for PARP-1 over PARP-2 (Kd 0.009 μM vs 1.39 μM, respectively).
||NNC-0640 is a potent negative allosteric modulator (NAM) of human G-protein-coupled glucagon receptor (GCGR) with IC50 of 69.2 nM.
NNMTi (Compound 1k, NNMT inhibitor) is a potent nicotinamide N-methyltransferase (NNMT) inhibitor with an IC50 of 1.2 μM.
||Nobiletin (NSC 76751)
||Nobiletin (NSC 76751, Hexamethoxyflavone), a citrus flavonoid isolated from citrus peels like in tangerine, which has anti-inflammatory and anti-tumor activities.
||Nocodazole (R17934, Oncodazole, NSC238159) is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM in cell-free assays, respectively. Nocodazole induces apoptosis.
||NOD-IN-1 (MDK19922, Compound 4) is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptor 1 (NOD1) and NOD2 with IC50 of 5.74 μM and 6.45 μM, respectively.
||Nodakenetin (NANI), a plant-derived coumarin isolated from Angelica decursiva, inhibits α-glucosidase, PTP1B, rat lens aldose reductase (RLAR), AChE, BChE, and β-site amyloid precursor protein cleaving enzyme 1 (BACE1). Nodakenetin alters the protein expression of Bax and Bcl-2, and prompts mitochondrial apoptosis. Nodakenetin exhibits anti-tumor activity.
||Nodakenin ((+)-Marmesinin), a coumarin compound, acts as an AChE inhibitor that inhibits AChE activity in a dosedependent manner with an IC50 value of 84.7 μM.
Nodosin is a diterpenoid isolated from <i>Isodon trichocarpus</i> Kudo and <i>I. Japonicus</i> HARA.
||Nomegestrol Acetate is a potent, highly selective progestogen, which is characterized as a full agonist at the progesterone receptor, with no or minimal binding to other steroid receptors, including the androgen and glucocorticoid receptors.
||Nomilin is a triterpenoid present in common edible citrus fruits with putative anticancer properties.
||Nonadecanoic acid (Nonadecylic acid, Nonadecanoate) is a long saturated fatty acid found in ox fats and vegetable oils, and in Staphylococcus. It can be used as a phermone by certain insects.
||Nonaethylene glycol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Nonaethylene glycol monomethyl ether
||Nonaethylene glycol monomethyl ether is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Nonanoic acid (Pelargonic acid, Nonoic acid) is a naturally occurring fatty acid found in both vegetable and animal fats.
||Nonivamide (pelargonic acid vanillylamide, Pseudocapsaicin, Vanillyl-N-nonylamide), present in chili peppers, is commonly manufactured synthetically and used as a food additive to add pungency to seasonings, flavorings, and spice blends. Nonivamide is a agonist, which exhibits 4d-EC50 value of 5.1 mg/L in static toxicity tests.
||Nonoxynols (Nonaethylene glycol, Polyethylene glycol nonyl phenyl ether) are nonionic surfactants used as detergents, emulsifiers, wetting agents or defoaming agents. Nonoxynol-9 (N-9), the compound with 9 repeating ethoxy groups, is an over-the-counter, locally acting vaginal spermicide.
||Nootkatone, a natural ingredient that occurs in grapefruit and certain other plants, has antioxidant and anti-inflammatory effects.
||Nor-NOHA acetate (Nω-Hydroxy-nor-L-Arginine acetate, N-OMega-hydroxy-L-norarginine acetate, N-Hydroxy-nor-L-arginine acetate) is a reversible, competitive inhibitor of arginase. Nor-NOHA inhibits arginase activity in aorta with an IC50 of less than 1 μM, that is, similar to its effects on liver arginase (IC50 = 0.5 μM).
||Noradrenaline bitartrate monohydrate
||Noradrenaline bitartrate monohydrate (Levophed) is a direct alpha-adrenergic receptors stimulator.
Norathyriol (Mangiferitin) is a natural metabolite of <i>Mangifera</i>. Norathyriol inhibits α-glucosidase in a noncompetitive manner with an IC50 of 3.12 μM. Norathyriol inhibits <b>PPARα</b>, <b>PPARβ</b>, and <b>PPARγ </b> with IC50s of 92.8 µM, 102.4 µM, and 153.5 µM, respectively. Antioxidant, anticancer, antimicrobial, anti-inflammatory, anti-bacterial activities.
||Norbenzetimide is prepared from benzetimide by catalytic transfer hydrogenolysis.
||Norcantharidin (Endothall anhydride) is a synthetic anticancer compound which is a dual inhibitor for c-Met and EGFR in human colon cancers.
Nordihydrocapsaicin is a capsaicinoid and analog and congener of capsaicin in chili peppers (Capsicum).
||Nordihydroguaiaretic acid (NDGA)
||Nordihydroguaiaretic acid (NDGA) is a phenolic antioxidant found in the leaves and twigs of the evergreen desert shrub, Larrea tridentata (Sesse and Moc. ex DC) Coville (creosote bush). It is a recognized inhibitor of lipoxygenase (LOX) and has antioxidant and free radical scavenging properties. Nordihydroguaiaretic acid (NDGA) is a cytotoxic insulin-like growth factor-I receptor (IGF-1R)/HER2 inhibitor and induces apoptosis. Nordihydroguaiaretic acid (NDGA) inhibits p300 and activates autophagy. Nordihydroguaiaretic acid (NDGA) protects cells from ferroptosis.
||Norethindrone (Norethisterone) is a synthetic progestin, which mimic the actions of the endogenous ovarian hormone progesterone.
||Norethindrone acetate (19-Norethindrone acetate, NA) is a common synthetic hormone used in oral contraceptives. Norethindrone acetate is a well-tolerated, effective option to manage pain and bleeding for all stages of endometriosis.
||Norethisterone Enanthate (Norethindrone Enanthate) is a form of progestogen-only injectable birth control which is used to prevent pregnancy in women.
||Norfloxacin (MK-0366) is a broad-spectrum antibiotic. Norfloxacin (MK-0366) targets bacterial gyrase and topoisomerase IV enzymes.
||Norgestimate, a synthetic progesterone analog, is an orally active progestin with highly selective progestational activity and minimal androgenicity.
||Norgestrel (WY-3707, SH-70850, SH-850, FH 122-A) is synthetic steroidal progestin that is used in combination with ethinyl estradiol for oral contraception. It also has strong neuroprotective activity.
||Norharmane (Norharman) is a potent and selective monoamine oxidase A (MAO-A) inhibitor with a Ki of 3.34 μM.
Noricaritin is a flavonoid sourced from roots of Epimedium brevicornu Maxim.
||Norisoboldine (Laurelliptine), a natural aryl hydrocarbon receptor (AhR) agonist, attenuates ulcerative colitis (UC) and induces the generation of Treg cells.
||Nortrachelogenin (Pinopalustrin, NSC698802, (-)-Wikstromol, (-)-Nortrachelogenin), isolated from Partrinia scabiosaefolia, elicits an apoptotic response in Candida albicans.
||Nortriptyline hydrochloride (Desitriptyline, ELF-101, EN-7048, Desmethylamitriptyline) is the hydrochloride salt form of nortriptyline, a tricyclic antidepressant agent used for short-term treatment of various forms of depression.
||Nortropine Hydrochloride (Nortropeno) is a secondary metabolite of tropine derivative drugs, such as atropine and benztropine.
||Norwogonin, isolated from Scutellaria baicalensis Georgi, possesses antiviral activity against Enterovirus 71 (EV71).
||NOTA, i.e. 1,4,7-triazacyclononane-1,4,7-triacetic acid, is a bifunctional chelating agent that has attracts the interest of the scientific community for its high complexation constant with metals like gallium.
||Notoginsenoside Fa, a protopanaxadiol (ppd)-type saponin isolated from P. notoginseng, could possibly activate and recover the function of degenerated brain.
Notoginsenoside Fc, a protopanaxadiol-(PPD-) type saponin isolated from the leaves of Panax notoginseng, effectively counteracts platelet aggregation. Notoginsenoside Fc can accelerate reendothelialization following vascular injury in diabetic rats by promoting autophagy.
||Notoginsenoside R1 (Sanchinoside R1) is the main ingredient with cardiovascular activity in Panax notoginseng. It inhibits TNF-α-induced PAI-1 overexpression via extracellular signal-related kinases (ERK1/2) and phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling pathways.
||Novaluron (Rimon) belongs to the class of insecticides called insect growth regulators with pesticide properties.
||Novobiocin Sodium (NSC 2382)
||Novobiocin Sodium (NSC 2382, Albamycin, Cathomycin) is an aminocoumarin antibiotic that targets bacterial DNA gyrase (TopoIV), used to treat susceptible gram positive bacteria.
||NP-G2-044 is a potent, orally active inhibitor of the actin-bundling activity of fascin with IC50 of ~0.2 μM. NP-G2-044 blocks tumor metastasis and increases antitumor immune response.
||NP118809(39-1B4) is a potent N-type calcium channel blocker, with an IC50 of 0.11 μM, also less potently inhibits L-type calcium channel with an IC50 of 12.2 μM.
||NPD8733 is an inhibitor of cancer cell-enhanced fibroblast migration that specifically binds to valosin-containing protein (VCP)/p97, a member of the ATPase-associated with diverse cellular activities (AAA+) protein family.
||NPS-1034 is a dual Met (c-Met)/Axl inhibitor with IC50 of 48 nM and 10.3 nM, respectively.
||NPS-2143 (SB262470) is a novel potent and selective antagonist of Ca(2+) receptor with IC50 of 43 nM.
||NQ301 (Compound 211), an antiplatelet and antithrombotic agent, is a selective CD45 inhibitor with IC50 of 200 nM. NQ301 inhibits thromboxane A2 receptor (TXA2) and synthase activity in rabbit platelets.
||NQTrp, an aromatic naphthoquinone-tryptophan hybrid molecule, an inhibitor of the aggregation of the tau protein with generic anti-amyloidogenic effects. NQTrp inhibits the in vitro aggregation of hexapeptide (41GCWMLY46 within the N-terminus of γD-crystallin) as well as full-length γD-crystallin.
NRD167 is a potent and selective SIRT5 inhibitor.
||NS11394 is a subtype-selective positive allosteric modulator at GABAA receptors, with selectivity for the α3 and α5 subtypes.
||NS 1738 (NSC 213859) is a novel positive allosteric modulator of the α7 nicotinic acetylcholine receptor (α7 nAChR), with respect to positive modulation of Xenopus laevis oocyte α7 nAChR with EC50 of 3.4 μM, as well as a comparable efficacy at the rat α7 nAChR with EC50 of 3.9 μM.
||NS-1619 is a selective activator of large conductance Ca2+-activated K+-channels.
||NS-398 (N-(2-cyclohexyloxy-4-nitrophenyl)methane sulfonamide) is a selective inhibitor of cyclooxygenase-2 (COX-2). The IC50 values for human recombinant COX-1 and -2 are 75 and 1.77 μM, respectively.
||NS13001 is a potent, selective, orally active allosteric positive modulator of SK channels (small conductance calcium-activated potassium channels) with EC50 of 1.8 μM and 0.14 μM for SK2 and SK3, respectively.
||NS1643 is one of the small molecule HERG (Kv11.1) channel activators and has also been found to increase erg2 (Kv11.2) currents.
||NS1652 is a reversible chloride channel blocker, potently inhibits the chloride conductance (IC50 = 1.6 μM) in human and mouse red blood cells, but only weakly volume activated anion conductance (VRAC) (IC50 = 125 μM) in HEK293 cells.
NS309 is a potent and selective activator of human Ca2+ -activated K+ channels of SK and IK types with an EC50 of 150 nM for hSK3 channel, and displays no activity at BK channels.
||NS-6180 is a highly selective inhibitor of KCa3.1 ion channel with IC50 value of 9 nM, which inhibits T cell activation and inflammation.
||NS8593 is a potent negative gating inhibitor of small conductance Ca2+
-activated K+ channels (SK1-3 or Kca2.1-2.3 channels). NS8593 is also a potent inhibitor of the TRPM7 channel with an IC50 of 1.6 µM.
||NSAH (HNASH) is a reversible and competitive nonnucleoside ribonucleotide reductase (RNR) inhibitor, with cell-free IC50 of 32 μM and cell-based IC50 of ~250 nM, respectively.
||NSC 102533 is a bioactive compound.
||NSC185058 inhibits ATG4B, the lipidation of LC3B, and autophagy without affecting the MTOR or PtdIns3K pathways.
||NSC 191412 (1-(4-Fluorophenyl)-3-phenylthiourea) is an active compound.
||NSC 207895 (XI-006) suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.
||NSC 31150 is a bioactive compound.
||NSC 31152 is a bioactive compound.
||NSC 31153 is a bioactive compound.
||NSC 31156 is a bioactive compound.
||NSC 31205 is an inhibitor of PIM2/1.
||NSC 31206 is a bioactive compound.
||NSC 409012 is an active compound.
||NSC42834 (JAK2 Inhibitor V, Z3) is an inhibitor of the autophosphorylation of wild type and V617F mutant forms of JAK2 with IC50 values between 10 and 30 μM.
||NSC 48107 (OR59402, NSC 4810, 4-Chloro-N,N-diisopropylbenzamide) is a bioactive compound.
||NSC 55655 is a bioactive compound.
||NSC 6038 is a bioactive compound.
||NSC 632839 is not only a DUB inhibitor, but also a deSUMOylase inhibitor, it inhibits USP2, USP7, and SENP2 with EC50 of 45 μM, 37 μM, and 9.8 μM, respectively.
||NSC 80538 (1-(4-Chlorophenyl)-3-(4-fluorophenyl)thiourea) is an inhibitor of MEK Kinase PB1 Domains in Multiplex HTS Assay.
||NSC-41589 (N-(2-(Methylthio)phenyl)acetamide), an N-[2-(methylsulfanyl) phenyl]acetamide.
||NSC-60339 is an efflux pump inhibitor and a substrate of AcrAB-TolC. NSC-60339 is a polybasic terephthalic acid derivative that has been studied as a potential cancer chemotherapeutic agent.
||NSC-703786 (5F-203) is a cytotoxic molecule that forms DNA adducts leading to cell death. NSC-703786 induces aryl hydrocarbon receptor signaling, and elevates expression of CYP1A1. Treatment of cells with NSC-703786 also leads to elevation of reactive oxygen species and activation of p38, JNK and ERK.
||NSC12 (NSC 172285) is an orally available pan-FGF trap able to inhibit FGF2/FGFR interaction and endowed with promising antitumor activity.
||NSC 15364 (compound 59) is an inhibitor that directly interacts with VDAC1 and prevents VDAC1 oligomerization, concomitant with an inhibition of apoptosis.
||NSC 23005 is a small molecule inhibitor of p18 (ED50=5.21 nM).
||NSC232003 is a highly potent and cell-permeable UHRF1 inhibitor that binds to the 5mC binding pocket of the SRA domain of UHRF1. NSC232003 modulates DNA methylation in a cellular context.
||NSC348884, as a nucleophosmin inhibitor, inhibit cell proliferation and induce apoptosis in various cancer cell lines with IC50 values ranging from 1.4-4 µM.
||NSC45586 is an inhibitor of PHLPP (Pleckstrin homology domain and leucine-rich repeat protein phosphatase), which is selective for PHLPP1 and PHLPP2.
||NSC5844 (RE-640) is a 4-aminoquinoline derivative with antitumor and antimalarial activity.
||NSC622608 is a first small-molecule ligand for V-domain Ig Suppressor of T-cell Activation (VISTA) with an IC50 of 4.8 μM in TR-FRET assay.
||NSC745887, an anticancer agent, traps DNA-topoisomerase cleavage and suppresses DcR3-associated signaling pathways, causing apoptosis by the caspase-8/9-caspase-3-poly(ADP-ribose) polymerase cascade.
||NSC-87877 is a cell-permeable inhibitor of both SHP-1 and SHP-2 with IC50 values of 355 and 318 nM respectively. It also inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation.
||NSC 95397 is a potent, selective Cdc25 dual specificity phosphatase inhibitor with Ki of 32 nM, 96 nM, 40 nM for Cdc25A, Cdc25B and Cdc25C, respectively. NSC 95397 has IC50 of 22.3 nM, 56.9 nM and 125 nM for human Cdc25A, human Cdc25C and Cdc25B, respectively. NSC 95397 inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) and suppresses proliferation and induces apoptosis in colon cancer cells through MKP-1 and ERK1/2 pathway.
||NSI-189, a small molecule with enhanced neurogenic activity, is a potential antidepressant for the treatment of major depressive disorder (MDD), cognitive impairment and neurodegeneration.
||NT157, a selective inhibitor of IRS-1/2(insulin receptor substrate), has the potential to inhibit IGF-1R and STAT3 signaling pathways in cancer cells and stroma cells of TME leading to a decrease in cancer cell survival.
||NTP42 is a novel antagonist of thromboxane A2 (TXA2) receptor with IC50 of 3.278 nM for antagonizing T prostanoid receptor (TP)- mediated [Ca2+] mobilization following stimulation of cells with the alternative TP agonist U46609. NTP42 is currently in development for the treatment of pulmonary arterial hypertension (PAH).
||NU1025 (NSC 696807) is a potent PARP inhibitor with IC50 of 400 nM.
||NU2058 (O(6)-Cyclohexylmethylguanine) is an inhibitor of CDK2 with IC50 value of 17 μM in an isolated enzyme assay. It also potentiates melphalan (DMF 2.3), and monohydroxymelphalan (1.7), but not temozolomide or ionising radiation.
||NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-aminopurine-based inhibitors.
||NU7026 (LY293646) is a potent DNA-PK inhibitor with IC50 of 0.23 μM in cell-free assays, 60-fold selective for DNA-PK than PI3K and inactive against both ATM and ATR. NU7026 enhances G2/M cell arrest and apoptosis.
||NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits mTOR and PI3K with IC50 of 1.7 μM and 5 μM in cell-free assays, respectively. It reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage.
||Nuciferine (Sanjoinine E, (-)-Nuciferine, VLT 049) is a major active aporphine alkaloid from the leaves of N. nucifera Gaertn and possesses anti-hyperlipidemia, anti-hypotensive, anti-arrhythmic, and insulin secretagogue activities. Nuciferine is an antagonist at 5-HT2A (IC50=478 nM), 5-HT2C (IC50=131 nM), and 5-HT2B (IC50=1 μM), an inverse agonist at 5-HT7 (IC50=150 nM), a partial agonist at D2 (EC50=64 nM), D5 (EC50=2.6 μM) and 5-HT6 (EC50=700 nM), an agonist at 5-HT1A (EC50=3.2 μM) and D4 (EC50=2 μM) receptor.
||Nucleoside Analogue Library
||A unique collection of 195 nucleoside analogues used for high throughput screening(HTS) and high content screening(HCS).
||Nucleozin is an antivirus agent that targets influenza A nucleoprotein (NP). Nucleozin triggers the aggregation of NP and inhibits its nuclear accumulation.
Nudifloric acid (1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid), isolated from Cordyceps bassiana, which is one of Cordyceps species with anti-oxidative, anti-cancer, anti-inflammatory, anti-diabetic, anti-obesity, anti-angiogenic, and anti-nociceptive activities.
Nuezhenidic acid, isolated from the fruits of Ligustrum lucidum, possesses inhibitory activities against influenza A virus.
||Nutlin-3 is a potent and selective Mdm2 (RING finger-dependent ubiquitin protein ligase for itself and p53) antagonist with IC50 of 90 nM in a cell-free assay; stabilizes p73 in p53-deficient cells.
||Nutlin-3a ((-)-Nutlin-3), the active enantiomer of Nutlin-3, inhibits the p53/MDM2 interaction with IC50 of 90 nM in a cell-free assay. Nutlin-3a induces autophagy and apoptosis in a p53-dependent manner.
||Nutlin-3b ((+)-Nutlin-3) is a p53/MDM2 antagonist or inhibitor with IC50 value of 13.6 μM, 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a.
||Nuzhenide (Specnuezhenide), a major component of olive seeds, is a member of the class of compounds known as saccharolipids. It has strong antioxidant activity.
||NVP 231 is a novel CerK inhibitor that inhibits the catalytic activity of recombinant CerK in vitro with an IC50 of 12 nM. NVP 231 induces cell apoptosis by increasing DNA fragmentation and caspase-3 and caspase-9 cleavage.
||NVP-2, a potent, selective, non-neurotoxic and ATP-competitive cyclin dependent kinase 9 (CDK9) inhibitor with IC50 of 0.514 nM for CDK9/CycT activity and induces cell apoptosis.
||NVP-ADW742 (GSK 552602A) is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.
||NVP-AEW541 is a potent inhibitor of IGF-1R/InsR with IC50 of 150 nM/140 nM in cell-free assays, greater potency and selectivity for IGF-1R in a cell-based assay.
||NVP-BEP800 (VER82576) is a novel, fully synthetic HSP90β inhibitor with IC50 of 58 nM, exhibits>70-fold selectivity against Hsp90 family members Grp94 and Trap-1.
||NVP-BHG712 isomer, a regioisomer of NVP-BHG712, shows conserved non-bonded binding to EphA2 and EphB4.
||NVP-BSK805 2HCl is a potent and selective ATP-competitive JAK2 inhibitor with IC50 of 0.5 nM,>20-fold selectivity towards JAK1, JAK3 and TYK2.
||NVP-BVU972 is a selective and potent Met (c-Met) inhibitor with IC50 of 14 nM.
||NVP-CGM097 is a highly potent and selective MDM2 inhibitor with Ki value of 1.3 nM for hMDM2 in TR-FRET assay. It binds to the p53 binding-site of the Mdm2 protein, disrupting the interaction between both proteins, leading to an activation of the p53 pathway.
||NVP-DKY709 is a potent IKZF2 inhibitor for the treatment of cancers.
||NVP-VID-400 (SDZ285428) is an inhibitor of CYP51. NVP-VID-400 (SDZ285428) inhibits T. cruzi and T. brucei with I/E2a(5 min) of both <1 and I/E2(60 min) of 9 and 35, respectively.
||NVR 3-778, belonging to the SBA (sulfamoylbenzamide) class, is a first-in-Class and oral bioavailable HBV CAM (capsid assembly modulator). NVR 3-778 exhibits anti-HBV activity.
||NVS-ZP7-4,a Zinc transporter SLC39A7 (ZIP7) inhibitor,is the first reported chemical tool to probe the impact of modulating ER zinc levels and investigate ZIP7 as a novel druggable node in the Notch pathway.
||NXY-059 (Disufenton sodium)
||NXY-059 (Cerovive, Disufenton Sodium) is a novel nitrone, shows efficacious neuroprotective effects. Phase 3.
||Nylidrin Hydrochloride (Buphenine), a β-adrenergic agonist, is used therapeutically for its vasodilating effect on the peripheral circulation and possibly on the cerebral circulation as well.
||Nystatin, which belongs to the polyene group of antimycotics, is frequently used as a topical agent in the treatment of oro-pharyngeal candidosis.
||Nystose (1,1-Kestotetraose, Fungitetraose), a constituent of seeds of onions and roots of Asparagus, is a low-calorie sweetening agent for food and chewing gum.
Nα-Acetyl-L-asparagine (N-Acetylasparagine, (S)-2-acetamido-4-amino-4-oxobutanoic acid) is an endogenous metabolite that exists in human brain.
Nα-Acetyl-L-lysine (Ac-Lys-OH, N(alpha)-Acetyllysine) is an active endogenous metabolite.
||Nicotinamide mononucleotide (β-NM, NMN), one of the key precursors of NAD+ and products of the NAMPT reaction , is converted to NAD+ by nicotinamide mononucleotide adenylyltransferase.