Acamprosate Calcium

For research use only.

Catalog No.S3748 Synonyms: N-Acetylhomotaurine Calcium, calcium acetylhomotaurinate

Acamprosate Calcium Chemical Structure

CAS No. 77337-73-6

Acamprosate (N-Acetylhomotaurine, Calcium acetylhomotaurinate), is a synthetic compound with a chemical structure similar to the amino acid neurotransmitter gamma-aminobutyric acid (GABA) and the amino acid neuromodulator taurine.

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Biological Activity

Description Acamprosate (N-Acetylhomotaurine, Calcium acetylhomotaurinate), is a synthetic compound with a chemical structure similar to the amino acid neurotransmitter gamma-aminobutyric acid (GABA) and the amino acid neuromodulator taurine.
In vitro

Acamprosate binds to a specific spermidine-sensitive site that modulates the NMDA receptor in a complex way[1].

In vivo Acamprosate is absorbed via the gastrointestinal tract, with pharmacokinetic linearity in terms of dose and time. Absolute bioavailability of acamprosate under fasting conditions is approximately 11%. After food intake, bioavailability decreases by approximately 20%, but this decrease lacks clinical significance. Steady-state plasma concentrations of acamprosate are reached within 5 days of dosing and the terminal half-life ranges from 20–33 hours following the standard 2 × 333 dosing regime. Plasma protein binding is negligible. Acamprosate is not metabolized in the liver and is excreted unchanged in the urine. Acamprosate may have neuroprotective effects. Acamprosate appears to work by normalizing the dysregulation of NMDA-mediated glutamatergic neurotransmission that occurs during chronic alcohol consumption and withdrawal, and thus attenuates one of the physiological mechanisms that may prompt relapse[1].

Protocol

Solubility (25°C)

In vitro Water 40 mg/mL (199.76 mM)
DMSO Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 200.24
Formula

C5H11NO4S.1/2Ca

CAS No. 77337-73-6
Storage powder
in solvent
Synonyms N-Acetylhomotaurine Calcium, calcium acetylhomotaurinate
Smiles CC(=O)NCCCS(=O)(=O)[O-].CC(=O)NCCCS(=O)(=O)[O-].[Ca+2]

In vivo Formulation Calculator (Clear solution)

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Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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The Serial Dilution Calculator Equation

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Molecular Weight Calculator

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT00662571 Completed Drug: acamprosate Alcoholism Mayo Clinic|Samuel C. Johnson Foundation May 2008 --
NCT00656630 Completed Drug: Acamprosate|Drug: Naltrexone|Drug: Placebo Alcoholism The Scripps Research Institute|National Institute on Alcohol Abuse and Alcoholism (NIAAA) December 2007 Phase 2
NCT00590642 Completed -- Obsessive Compulsive Disorder Creighton University|Forest Laboratories April 2006 --

Tech Support

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