Acamprosate Calcium

For research use only.

Catalog No.S3748 Synonyms: N-Acetylhomotaurine Calcium, calcium acetylhomotaurinate

Acamprosate Calcium Chemical Structure

CAS No. 77337-73-6

Acamprosate (N-Acetylhomotaurine, Calcium acetylhomotaurinate), is a synthetic compound with a chemical structure similar to the amino acid neurotransmitter gamma-aminobutyric acid (GABA) and the amino acid neuromodulator taurine.

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Biological Activity

Description Acamprosate (N-Acetylhomotaurine, Calcium acetylhomotaurinate), is a synthetic compound with a chemical structure similar to the amino acid neurotransmitter gamma-aminobutyric acid (GABA) and the amino acid neuromodulator taurine.
In vitro

Acamprosate binds to a specific spermidine-sensitive site that modulates the NMDA receptor in a complex way[1].

In vivo Acamprosate is absorbed via the gastrointestinal tract, with pharmacokinetic linearity in terms of dose and time. Absolute bioavailability of acamprosate under fasting conditions is approximately 11%. After food intake, bioavailability decreases by approximately 20%, but this decrease lacks clinical significance. Steady-state plasma concentrations of acamprosate are reached within 5 days of dosing and the terminal half-life ranges from 20–33 hours following the standard 2 × 333 dosing regime. Plasma protein binding is negligible. Acamprosate is not metabolized in the liver and is excreted unchanged in the urine. Acamprosate may have neuroprotective effects. Acamprosate appears to work by normalizing the dysregulation of NMDA-mediated glutamatergic neurotransmission that occurs during chronic alcohol consumption and withdrawal, and thus attenuates one of the physiological mechanisms that may prompt relapse[1].


Solubility (25°C)

In vitro Water 40 mg/mL (199.76 mM)
DMSO Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 200.24


CAS No. 77337-73-6
Storage powder
in solvent
Synonyms N-Acetylhomotaurine Calcium, calcium acetylhomotaurinate
Smiles CC(=O)NCCCS(=O)(=O)[O-].CC(=O)NCCCS(=O)(=O)[O-].[Ca+2]

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT00662571 Completed Drug: acamprosate Alcoholism Mayo Clinic|Samuel C. Johnson Foundation May 2008 --
NCT00656630 Completed Drug: Acamprosate|Drug: Naltrexone|Drug: Placebo Alcoholism The Scripps Research Institute|National Institute on Alcohol Abuse and Alcoholism (NIAAA) December 2007 Phase 2
NCT00590642 Completed -- Obsessive Compulsive Disorder Creighton University|Forest Laboratories April 2006 --

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