Home Immunology & Inflammation Immunology & Inflammation related chemical Aceclofenac

research use only

Aceclofenac Immunology & Inflammation related chemical

Cat.No.S4835

Aceclofenac (Preservex, Airtal) is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties.
Aceclofenac Immunology & Inflammation related chemical Chemical Structure

Chemical Structure

Molecular Weight: 354.18

Jump to

Quality Control

Batch: S483501 DMSO]70 mg/mL]false]]]false]]]false Purity: 99.83%
99.83

Solubility

In vitro
Batch:

DMSO : 70 mg/mL (197.63 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Molarity Calculator

Mass Concentration Volume Molecular Weight
Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg
g
μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO
%
% Tween 80
% ddH2O
% DMSO
+
%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 354.18 Formula

C16H13Cl2NO4

 Storage (From the date of receipt)
CAS No. 89796-99-6 -- Storage of Stock Solutions

Synonyms Preservex, Airtal Smiles C1=CC=C(C(=C1)CC(=O)OCC(=O)O)NC2=C(C=CC=C2Cl)Cl

Mechanism of Action

In vivo
Long term oral administration of aceclofenac causes gastrointestinal (GI) ulcers and GI bleeding. Aceclofenac is well absorbed orally with hepatic first pass metabolism. It exhibits elimination half life of 4h, volume of distribution 25 L, 99 % of protein binding and 60-70% of bioavailability after oral administration.
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05558150 Completed
Drug Interaction Potentiation
Il-Yang Pharm. Co. Ltd.
 November 10 2022 Phase 1

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.