Aceclofenac

Catalog No.S4835 Synonyms: Preservex, Airtal

For research use only.

Aceclofenac (Preservex, Airtal) is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties.

Aceclofenac Chemical Structure

CAS No. 89796-99-6

Purity & Quality Control

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Biological Activity

Description Aceclofenac (Preservex, Airtal) is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties.
In vivo Long term oral administration of aceclofenac causes gastrointestinal (GI) ulcers and GI bleeding. Aceclofenac is well absorbed orally with hepatic first pass metabolism. It exhibits elimination half life of 4h, volume of distribution 25 L, 99 % of protein binding and 60-70% of bioavailability after oral administration[1].

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 70 mg/mL
(197.63 mM)
Ethanol '-1 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 354.18
Formula

C16H13Cl2NO4

CAS No. 89796-99-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC=C(C(=C1)CC(=O)OCC(=O)O)NC2=C(C=CC=C2Cl)Cl

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

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% DMSO % % Tween 80 % ddH2O
%DMSO %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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