Catalog No.S1630

Allopurinol  Chemical Structure

Molecular Weight(MW): 136.11

Allopurinol is a purine analog inhibitor of the enzyme xanthine oxidase, used to treat gout or kidney stones, and to decrease levels of uric acid.

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In DMSO USD 160 In stock
USD 120 In stock
USD 207 In stock
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Biological Activity

Description Allopurinol is a purine analog inhibitor of the enzyme xanthine oxidase, used to treat gout or kidney stones, and to decrease levels of uric acid.
xanthine oxidase [1]
In vitro

Allopurinol reverses the increased xanthine oxidase activity in ischemia-reperfusion injury of neonatal rat hearts. Allopurinol (10 mM) treatment suppresses xanthine oxidase activity induced by hypoxia-reoxygenation injury and the production of reactive oxygen species. Allopurinol also decreases the concentration of intracellular Ca2+ increased by enhanced xanthine oxidase activity. [1]

In vivo Allopurinol shows abnormal pyrimidine metabolism together with renal toxicity which could be ameliorated by uridine, indicating that Allopurinol essentially causes pyrimidine metabolism abnormality leading to renal impairment in normal mice. Allopurinol increases urinary OD excretion to an extent similar to that in normal mice administered the same dose of Allopurinol in DNFB-sensitized mice. [2] Allopurinol promotes a clinical improvement which is accompanied by a reduction in the parasitic load in the blood, skin and lymph nodes but, even after long period of allopurinol administration alone, Leishmania may persist in dog tissues in Leishmania-infected dogs. [3] Allopurinol prevents early alcohol-induced liver injury in rats, most likely by preventing oxidant-dependent activation of NF-kappaB. [4] Allopurinol protects dose-dependently against acetaminophen-induced cell injury, the loss of ATP and the increase of the GSSG content in the total liver and in the mitochondrial compartment without inhibiting reactive metabolite formation in mice. Allopurinol almost completely inhibits hepatic xanthine oxidase and dehydrogenase activity, but only high doses prevents the increase of the mitochondrial GSSG content. [5]


Solubility (25°C)

In vitro DMSO 27 mg/mL (198.36 mM)
Water 4 mg/mL (29.38 mM)
Ethanol 3 mg/mL (22.04 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 136.11


CAS No. 315-30-0
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03601260 Not yet recruiting Drug: Allopurinol Gout Hillel Yaffe Medical Center August 2018 Not Applicable
NCT02956278 Active not recruiting Drug: Allopurinol|Other: Placebo Chronic Gout|Hyperuricemia University of California San Francisco|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|Open Medicine Institute November 2016 Phase 4
NCT03046914 Unknown status Genetic: HLA-B*5801 test Stevens-Johnson Syndrome|Kidney Failure Chronic Seoul National University Hospital|Ministry of Food and Drug Safety Korea February 24 2016 Not Applicable

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID