Adefovir

Catalog No.S5068

Adefovir Chemical Structure

Molecular Weight(MW): 273.19

Adefovir is an orally administered nucleotide analog reverse transcriptase inhibitor used for treatment of hepatitis B and herpes simplex virus infection.

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Biological Activity

Description Adefovir is an orally administered nucleotide analog reverse transcriptase inhibitor used for treatment of hepatitis B and herpes simplex virus infection.
Targets
Reverse transcriptase [1]
()
In vitro

In vitro, adefovir is a potent inhibitor of viral replication in human hepatoma cell lines stably transfected with HBV and in primary duck hepatocytes infected with duck HBV (DHBV). Adefovir does not prevent initiation of infection in primary duck hepatocyte cultures. Adefovir is also reported to exhibit immunomodulatory effects, including stimulation of natural killer cell activity and interferon alpha production[1].

In vivo Adefovir has a poor oral bioavailability and it is usually used via intraperitoneal injection[1].

Protocol

Solubility (25°C)

In vitro Water 0.1 mg/mL (0.36 mM)
DMSO Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 273.19
Formula

C8H12N5O4P

CAS No. 106941-25-7
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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  • Computed Result

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    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
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Molecular Weight Calculator

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02327689 Unknown status Drug: Emtricitabine plus adefovir dipivoxil Hepatitis B Chronic|Fibrosis Asian-Pacific Alliance of Liver Disease Beijing|Beijing Ditan Hospital|Hebei Medical University Pharmaceutical Factory|National Health and Family Planning Commission P.R.China January 2015 Phase 4
NCT02327663 Unknown status Drug: Emtricitabine Hepatitis B Chronic Asian-Pacific Alliance of Liver Disease Beijing|Beijing Ditan Hospital|Hebei Medical University Pharmaceutical Factory|National Health and Family Planning Commission P.R.China December 2014 Phase 4
NCT01639066 Completed Drug: Tenofovir|Drug: Entecavir Chronic Viral Hepatitis B Without Delta-agent Asan Medical Center|Samsung Medical Center|Konkuk University Medical Center|Korea University Guro Hospital|Seoul National University Hospital September 25 2012 Phase 4

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Reverse Transcriptase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID