Home Microbiology Reverse Transcriptase inhibitor Adefovir

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Adefovir Reverse Transcriptase inhibitor

Cat.No.S5068

Adefovir is an orally administered nucleotide analog reverse transcriptase inhibitor used for treatment of hepatitis B and herpes simplex virus infection.
Adefovir Reverse Transcriptase inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 273.19

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Quality Control

Batch: S506801 5%TFA]6.04 mg/mL]false]Water]0.1 mg/mL]false]DMSO]Insoluble]false Purity: 99.96%
99.96

Solubility

In vitro
Batch:

5%TFA : 6.04 mg/mL

Water : 0.1 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

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Mass Concentration Volume Molecular Weight
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In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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%
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 273.19 Formula

C8H12N5O4P

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 106941-25-7 -- Storage of Stock Solutions

Synonyms N/A Smiles C1=NC(=C2C(=N1)N(C=N2)CCOCP(=O)(O)O)N

Mechanism of Action

Targets/IC50/Ki
Reverse transcriptase
In vitro
In vitro, adefovir is a potent inhibitor of viral replication in human hepatoma cell lines stably transfected with HBV and in primary duck hepatocytes infected with duck HBV (DHBV). This compound does not prevent initiation of infection in primary duck hepatocyte cultures. It is also reported to exhibit immunomodulatory effects, including stimulation of natural killer cell activity and interferon alpha production.
In vivo
Adefovir has a poor oral bioavailability and it is usually used via intraperitoneal injection.
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02956850 Completed
Hepatitis B Chronic
Hoffmann-La Roche
 December 12 2016 Phase 1
NCT02327689 Unknown status
Hepatitis B Chronic|Fibrosis
Asian-Pacific Alliance of Liver Disease Beijing|Beijing Ditan Hospital|Hebei Medical University Pharmaceutical Factory|National Health and Family Planning Commission P.R.China
 January 2015 Phase 4
NCT02327663 Unknown status
Hepatitis B Chronic
Asian-Pacific Alliance of Liver Disease Beijing|Beijing Ditan Hospital|Hebei Medical University Pharmaceutical Factory|National Health and Family Planning Commission P.R.China
 December 2014 Phase 4

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