Adefovir

Catalog No.S5068

For research use only.

Adefovir is an orally administered nucleotide analog reverse transcriptase inhibitor used for treatment of hepatitis B and herpes simplex virus infection.

Adefovir Chemical Structure

CAS No. 106941-25-7

Purity & Quality Control

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Biological Activity

Description Adefovir is an orally administered nucleotide analog reverse transcriptase inhibitor used for treatment of hepatitis B and herpes simplex virus infection.
Targets
Reverse transcriptase [1]
()
In vitro

In vitro, adefovir is a potent inhibitor of viral replication in human hepatoma cell lines stably transfected with HBV and in primary duck hepatocytes infected with duck HBV (DHBV). Adefovir does not prevent initiation of infection in primary duck hepatocyte cultures. Adefovir is also reported to exhibit immunomodulatory effects, including stimulation of natural killer cell activity and interferon alpha production[1].

In vivo Adefovir has a poor oral bioavailability and it is usually used via intraperitoneal injection[1].

Protocol (from reference)

Solubility (25°C)

In vitro

Water 0.1 mg/mL
(0.36 mM)
DMSO Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 273.19
Formula

C8H12N5O4P

CAS No. 106941-25-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=NC(=C2C(=N1)N(C=N2)CCOCP(=O)(O)O)N

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02327689 Unknown status Drug: Emtricitabine plus adefovir dipivoxil Hepatitis B Chronic|Fibrosis Asian-Pacific Alliance of Liver Disease Beijing|Beijing Ditan Hospital|Hebei Medical University Pharmaceutical Factory|National Health and Family Planning Commission P.R.China January 2015 Phase 4
NCT02327663 Unknown status Drug: Emtricitabine Hepatitis B Chronic Asian-Pacific Alliance of Liver Disease Beijing|Beijing Ditan Hospital|Hebei Medical University Pharmaceutical Factory|National Health and Family Planning Commission P.R.China December 2014 Phase 4
NCT01639066 Completed Drug: Tenofovir|Drug: Entecavir Chronic Viral Hepatitis B Without Delta-agent Asan Medical Center|Samsung Medical Center|Konkuk University Medical Center|Korea University Guro Hospital|Seoul National University Hospital September 25 2012 Phase 4

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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