Molecular Weight(MW): 273.19
Adefovir is an orally administered nucleotide analog reverse transcriptase inhibitor used for treatment of hepatitis B and herpes simplex virus infection.
Purity & Quality Control
Choose Selective Reverse Transcriptase Inhibitors
|Description||Adefovir is an orally administered nucleotide analog reverse transcriptase inhibitor used for treatment of hepatitis B and herpes simplex virus infection.|
In vitro, adefovir is a potent inhibitor of viral replication in human hepatoma cell lines stably transfected with HBV and in primary duck hepatocytes infected with duck HBV (DHBV). Adefovir does not prevent initiation of infection in primary duck hepatocyte cultures. Adefovir is also reported to exhibit immunomodulatory effects, including stimulation of natural killer cell activity and interferon alpha production.
|In vivo||Adefovir has a poor oral bioavailability and it is usually used via intraperitoneal injection.|
|In vitro||Water||0.1 mg/mL (0.36 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2
Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02327689||Unknown status||Drug: Emtricitabine plus adefovir dipivoxil||Hepatitis B Chronic|Fibrosis||Asian-Pacific Alliance of Liver Disease Beijing|Beijing Ditan Hospital|Hebei Medical University Pharmaceutical Factory|National Health and Family Planning Commission P.R.China||January 2015||Phase 4|
|NCT02327663||Unknown status||Drug: Emtricitabine||Hepatitis B Chronic||Asian-Pacific Alliance of Liver Disease Beijing|Beijing Ditan Hospital|Hebei Medical University Pharmaceutical Factory|National Health and Family Planning Commission P.R.China||December 2014||Phase 4|
|NCT01639066||Completed||Drug: Tenofovir|Drug: Entecavir||Chronic Viral Hepatitis B Without Delta-agent||Asan Medical Center|Samsung Medical Center|Konkuk University Medical Center|Korea University Guro Hospital|Seoul National University Hospital||September 25 2012||Phase 4|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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