Home Neuronal Signaling AChR agonist Acetylcholine iodide

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Acetylcholine iodide AChR agonist

Cat.No.S4718

Acetylcholine iodide (Acetylcolina) is a neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.
Acetylcholine iodide AChR agonist Chemical Structure

Chemical Structure

Molecular Weight: 273.11

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Quality Control

Batch: S471801 DMSO]54 mg/mL]false]Water]54 mg/mL]false]Ethanol]54 mg/mL]false Purity: 99.78%
99.78

Solubility

In vitro
Batch:

DMSO : 54 mg/mL (197.72 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 54 mg/mL

Ethanol : 54 mg/mL

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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 273.11 Formula

C7H16NO2.I

 Storage (From the date of receipt)
CAS No. 2260-50-6 Download SDF Storage of Stock Solutions

Synonyms Acetylcolina Smiles CC(=O)OCC[N+](C)(C)C.[I-]

Mechanism of Action

In vitro
Acetylcholine iodide (Ach) stimulated SBC3 cell proliferation, adhesion and migration toward fibronectin (Fn) in a dose-dependent manner. ACh ameliorates TNF-α-induced calpain activation by decreasing p38-MAPK phosphorylation and enhancing calpastatin expression. It elicits an anti-apoptotic effect through the activation of the muscarinic ACh receptor (MAChR) and the activation of anti-oxidant systems. ACh increases cell viability and decreases TNF-α-induced apoptosis in H9c2 cells.
In vivo
Acetylcholine can inhibit pro-inflammatory cytokine release and protect against cardiomyocyte injury.
References

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