ABT-751 (E7010)

For research use only.

Catalog No.S1165

5 publications

ABT-751 (E7010) Chemical Structure

CAS No. 141430-65-1

ABT-751 (E7010) binds to the colchicine site on β-tubulin and inhibits polymerization of microtubules, not a substrate for the MDR transporter and is active against cell lines resistant to vincristine, doxorubicin, and cisplatin. Phase 1/2.

Size Price Stock Quantity  
10mM (1mL in DMSO) USD 160 In stock
USD 120 In stock
USD 470 In stock
USD 1570 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Selleck's ABT-751 (E7010) has been cited by 5 publications

3 Customer Reviews

  • Cell viability in H292 monolayer cells after 3-day treatment and spheroid volume in H292 3D culture after 7-day treatment with ABT751. Data points are means ?SD for three individual experiments. IC50 values were calculated to emphasize the differences in drug potency in 2D verses 3D cultures. ABT751, IC50 of 177.2 ?17.3 nM for 2D and 670.2 ?257.6 nM for 3D.

    Bioorg Med Chem 2013 21, 922-31. ABT-751 (E7010) purchased from Selleck.

    3D spheroid integrity following treatment with ABT751. Representative phase contrast imagines of H292 multi-cellular 3D spheroid at the onset of the treatment and after a 7-day treatment interval with various concentrations. Magnification: 10 X objective, scan bar: 200 μm. Dose and time dependent curves of ABT751 with 3D spheroid assay.

    Bioorg Med Chem 2013 21, 922-31. ABT-751 (E7010) purchased from Selleck.

  • Western blot analysiswas used to validate the regulation of β1-tubulin to vinculin. (A) Inhibited effects of ABT-751 on the β1-tubulin.Washed human plateletswere treatedwith 0, 2.5, 5, 10 and 20 μg/ml ABT-751 for 60 min then stimulated with 0.3 U thrombin (B) Protein expression of vinculin and Talin1 in washed platelets. The representative bands were from different gels for repeated experiments. After densitometric analysis, the values of proteins were normalized against GAPDH, respectively. Data are shown as the mean ± S.D. (n =3-4 per group). ##P < 0.01 vs normal group, **P < 0.01 vs thrombin group, ++P < 0.01 vs thrombin group.

    Fitoterapia, 2017, 116:106-115. ABT-751 (E7010) purchased from Selleck.

Purity & Quality Control

Choose Selective Microtubule Associated Inhibitors

Biological Activity

Description ABT-751 (E7010) binds to the colchicine site on β-tubulin and inhibits polymerization of microtubules, not a substrate for the MDR transporter and is active against cell lines resistant to vincristine, doxorubicin, and cisplatin. Phase 1/2.
Features An orally bioavailable tubulin-binding and antimitotic sulfonamide.
Targets
Microtubules [1]
In vitro

In vitro, ABT-751 shows the selective cytotoxicity with IC50 of 0.6–2.6 μM in neuroblastoma and 0.7–4.6 μM in other solid tumor cell lines. Furthermore, ABT-751 also exhibits a selective effect on dynamic microtubules and spares stable microtubules, accounting for the persistence of acetylated and detyrosinated α-tubulin positive polymerized tubules at the IC90 concentration of ABT-751. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HCT-15 cell MWTQdo9tcW[ncnH0bY9vKGG|c3H5 NXvTZY1pSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDjc4xwdiClYYLjbY5wdWFiSFPUMVE2KGOnbHygcIlv\SiPRGKoMUkqNCCLQ{WwQVAvOzRizszN NVfpXnA2OTF2MkW1N|Q>
HCT116-C9 cell MnK0SpVv[3Srb36gZZN{[Xl? M{PJbWVn\mWldHn2[UBkd26lZX70doF1cW:wIITvJIlvcGmkaYSgZ4VtdCCycn;sbYZmemG2aX;uJIJ6KDVyJTDy[YxifGm4ZTD0c{B2dnS{ZXH0[YQh[2:wdILvcEBk\WyuIHHmeIVzKDd{IHjyJI9nKGOxboTpcpVwfXNiZYjwc5N2emViaX6gTGNVOTF4LVO5JINmdGxibHnu[UwhUUN3ME2wMlkh|ryP M2PMNVEzOzh|MEG3
NCI-H460 cell M{XBenBzd2yrZnXyZZRqd25iYYPzZZk> Moi2RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCudX7nJINiemOrbn;tZUBPS0lvSES2NEBk\WyuIHzpcoUhME2GUjirLUktKEmFNUC9NE4{PSEQvF2= NF\LWIIyOTR{NUWzOC=>
P388 cell line M4r3SGZ2dmO2aX;uJIF{e2G7 NIHhem04OiCq NGTWUHFG\m[nY4TpeoUh[2:wY3XueJJifGmxbjD0c{BqdmirYnn0JINmdGxicILvcIln\XKjdHnvckBjgSB3MDWgdoVt[XSrdnWgeI8hfW62cnXheIVlKGOxboTyc4wh[2WubDDh[pRmeiB5MjDodkBw\iClb370bY52d3W|IHX4dI9{fXKnIHnuJHA{QDhiY3XscEBtcW6n78{MJGlEPTB;MD6xPUDPxE1? MmS2NVI{QDNyMUe=
P388/4.0 r-M cell line NUjrb5lMTnWwY4Tpc44h[XO|YYm= Mof2O|IhcA>? NWi4R|lRTW[oZXP0bZZmKGOxbnPlcpRz[XSrb36geI8hcW6qaXLpeEBk\WyuIIDyc4xq\mW{YYTpc44h[nliNUClJJJmdGG2aY\lJJRwKHWwdILlZZRm\CClb370do9tKGOnbHygZYZ1\XJiN{KgbJIhd2ZiY3;ueIlvfW:3czDlfJBwe3W{ZTDpckBROzh6L{SuNEBzNU1iY3XscEBtcW6nLDDJR|UxRTF3IN88US=> M1zwdFEzOzh|MEG3
human HL60 cells MV;Qdo9tcW[ncnH0bY9vKGG|c3H5 MVnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiONkCgZ4VtdHNuIFnDOVA:OC5|NDFOwG0> M{nMXlE4Ojd4MEW2
HeLa cells M3PSUWN6fG:2b4jpZ4l1gSCjc4PhfS=> MVG0PE04OiCq NFvjU4xEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\UyjIHPlcIx{KGGodHXyJFQ5KHSxIEeyJIhzeyCkeTDXRXQuOSCjc4PhfUwhUUN3ME2wMlI4KM7:TR?= NG\zPWEzOTF{NkCyOy=>
MDR1 cells MlrpR5l1d3SxeHnjbZR6KGG|c3H5 NELOfmw1QC15MjDo NHPzNnBEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBPS0lvQVTSMXJGWyCneIDy[ZN{cW6pIF3EVlEh[2WubIOgZYZ1\XJiNEigeI8hPzJiaILzJIJ6KFeDVD2xJIF{e2G7LDDJR|UxRTBwMkmg{txO MYWyNVEzPjB{Nx?=
Jurkat cells MX7GeY5kfGmxbjDhd5NigQ>? NV\pWVZbOjRiaB?= M3;sTWNmdGxiY4njcIUh[XK{ZYP0JIlvKGi3bXHuJGp2emujdDDj[YxteyCjc4Pld5Nm\CCjczDhZ4N2dXWuYYTpc44h[XRiR{KvUUBxcGG|ZTDh[pRmeiB{NDDodpMhfXOrbnegdJJweGmmaYXtJIlw\GmmZTDzeIFqdmmwZzDifUBHSUOVIHHuZYx6e2m|LDDJR|UxRTBwMU[g{txO MX:yNVEzPjB{Nx?=
SW620 cells Mny4R5l1d3SxeHnjbZR6KGG|c3H5 NIC3UZk1QC15MjDo NYn1Oo1yS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW1d4MkCgZ4VtdHNiYX\0[ZIhPDhidH:gO|IhcHK|IHL5JHdCXC1zIHHzd4F6NCCLQ{WwQVAvOTlizszN MXyyNVEzPjB{Nx?=
A2780 cells NYrJSIUyS3m2b4TvfIlkcXS7IHHzd4F6 MoLPOFguPzJiaB?= M4HOXWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGEzPzhyIHPlcIx{KGGodHXyJFQ5KHSxIEeyJIhzeyCkeTDXRXQuOSCjc4PhfUwhUUN3ME2wMlE4KM7:TR?= MnjXNlEyOjZyMke=
HT-29 cells MoTCVJJwdGmoZYLheIlwdiCjc4PhfS=> MYi3NkBp MX;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiWLUK5JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:OC5{MTFOwG0> NHPvd3AzOzJyMki0PS=>
HUVEC M{PWUmZ2dmO2aX;uJIF{e2G7 MUWxNFAuOTByMDDuUS=> M1LZWFQhcA>? NXLpcWYxUW6mdXP0bY9vKG:oII\hd4N2dGG{IHTpd5J2eHSrbnegZYN1cX[rdImgbY4hUFWYRVOgZZN{\XO|ZXSgZZMhXkWJRj3pcoR2[2WmIIT1ZoUh\m:{bXH0bY9vKGG2IEGwNEB1dyBzMECwJI5OKGGodHXyJFQhcHK|IHL5JI1q[3Kxc3PvdIlkKGGwYXz5d4l{ NWHDWY5NOjRzME[5PFI>
H460 cells M3juPGN6fG:2b4jpZ4l1gSCjc4PhfS=> MlnYO|IhcA>? MV7DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIOFYxKGOnbHzzJIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBu\XSqeXzlcoUh[my3ZTDzeIFqdmmwZz3iZZNm\CCjc4PhfUwhUUN3ME2wMlIyPzdizszN NEXwWJozPDFyNkm4Ni=>
MKN45 cells M2jvUWN6fG:2b4jpZ4l1gSCjc4PhfS=> NULLflRFPzJiaB?= NH6xO2ZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOU052NTDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nlibXX0bJlt\W6nIHLseYUhe3SjaX7pcocu[mG|ZXSgZZN{[XluIFnDOVA:OC5zNk[g{txO M3fyNVI1OTB4OUiy
HT-29 cells MnfaR5l1d3SxeHnjbZR6KGG|c3H5 MWW3NkBp NH;Cd4hEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJXC1{OTDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nlibXX0bJlt\W6nIHLseYUhe3SjaX7pcocu[mG|ZXSgZZN{[XluIFnDOVA:OC5|M{i3JO69VQ>? NGDBNGMzPDFyNkm4Ni=>
human A549 cells MkHqR5l1d3SxeHnjbZR6KGG|c3H5 NXnpSotDPDhiaB?= MU\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MT6zNUDPxE1? MWiyOFg{PTd6Nh?=
ACHN cells NWrhWHVYS3m2b4TvfIlkcXS7IHHzd4F6 NXe2c3FJPDhiaB?= NFrJ[FJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCS0iQIHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUC9Nk4yOyEQvF2= NFfVOY8zPDh|NUe4Oi=>
MCF7 cells NIrr[XhEgXSxdH;4bYNqfHliYYPzZZk> M3fMVFQ5KGh? M2roNWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME2xMlI2KM7:TR?= NFvo[YIzPDh|NUe4Oi=>
HT-29 cells Ml\xR5l1d3SxeHnjbZR6KGG|c3H5 NX7OVod7PDhiaB?= M3\1[GN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhVNTJ7IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUC9NU43OiEQvF2= MmjUNlQ5OzV5OE[=
A549 cells MmrzVJJwdGmoZYLheIlwdiCjc4PhfS=> NYLPOJU1OjRiaB?= MVzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF3NEmgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiMkSgbJJ{KGK7IGPSRkBie3OjeTygS2k2OD1zLkOxJO69VQ>? M17kOFI2PDZ6MEO5
human MCF7 cells Mn:wVJJwdGmoZYLheIlwdiCjc4PhfS=> NWjWRmozOjRiaB?= NWLXVJBbSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFI1KGi{czDifUBUWkJiYYPzZZktKEeLNUC9NU4zPSEQvF2= NIHBUHAzPTR4OECzPS=>
KB-S15 cells M{HSWGN6fG:2b4jpZ4l1gSCjc4PhfS=> MWK3NkBp NF76R2NEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMSi2VMUWgZ4VtdHNib4\ldoV5eHKnc4PpcochWC2pcEG3NE9OTFJiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IH3leIh6dGWwZTDicJVmKHO2YXnubY5oNWKjc3XkJIF{e2G7LDDJR|UxRTBwMkC2JO69VQ>? MlmwNlQyODZ7OEK=
KB-7d cells M1jwc2N6fG:2b4jpZ4l1gSCjc4PhfS=> MojiO|IhcA>? MV;DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLRk04\CClZXzsd{BwfmW{ZYjwdoV{e2mwZzDNVnAh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KG2ndHj5cIVv\SCkbIXlJJN1[WmwaX7nMYJie2WmIHHzd4F6NCCLQ{WwQVAvOjB3IN88US=> Mmr4NlQyODZ7OEK=
KB-VIN10 cells NXy2ZWNLS3m2b4TvfIlkcXS7IHHzd4F6 M4nBW|czKGh? NVHZToJNS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hU0JvVlnONVAh[2WubIOgc5ZmemW6cILld5NqdmdiUD3ndFE4OC:PRGKgZZN{\XO|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO|IhcHK|IHL5JI1mfGi7bHXu[UBjdHWnIIP0ZYlvcW6pLXLhd4VlKGG|c3H5MEBKSzVyPUCuNlI4KM7:TR?= Mm\3NlQyODZ7OEK=
human PC3 cells MmWxR5l1d3SxeHnjbZR6KGG|c3H5 MUm0PEBp NHPFdZpEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBRSzNiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPDhiaILzJIJ6KHO3bH\vdohw\GGvaX7lJGIh[XO|YYmsJGdKPTB;MD62NkDPxE1? NVrSVmN6OjZ{NEGwN|I>
human AsPC1 cells Ml\ER5l1d3SxeHnjbZR6KGG|c3H5 M1vmUFQ5KGh? NV3rU25XS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSXOSQ{GgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiNEigbJJ{KGK7IIP1cIZwemixZHHtbY5mKEJiYYPzZZktKEeLNUC9OE4yOSEQvF2= MWmyOlI1OTB|Mh?=
human A549 cells NE\uWXREgXSxdH;4bYNqfHliYYPzZZk> MVm0PEBp MVPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFQ5KGi{czDifUB{fWyob4Loc4RidWmwZTDCJIF{e2G7LDDHTVUxRTVwM{Og{txO NXfpOXBEOjZ{NEGwN|I>
Hep3B cells MYTDfZRwfG:6aXPpeJkh[XO|YYm= NEj6SW81QCCq NXPMfXRUS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyM1KgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiNEigbJJ{KGK7IIP1cIZwemixZHHtbY5mKEJiYYPzZZktKEeLNUC9NE45PCEQvF2= Moe0NlYzPDFyM{K=
KB cells M4\T[2N6fG:2b4jpZ4l1gSCjc4PhfS=> NVzWb5ZiPzJiaB?= NInY[3pEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMSiClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhdWW2aIns[Y5mKGKudXWgd5RicW6rbnetZoF{\WRiYYPzZZktKEmFNUC9NE4zPTF|IN88US=> M1LGSlI1OTB4OUiy
DU145 cells M{PMcHBzd2yrZnXyZZRqd25iYYPzZZk> M1fibFI1KGh? MkfZRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCGVUG0OUBk\WyuczDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjCyOEBpenNiYomgV3JDKGG|c3H5MEBIUTVyPUGuPFEh|ryP MnHpNlU1PjhyM{m=
DU145 cells NYXYcpA6S3m2b4TvfIlkcXS7IHHzd4F6 NVW3b41XPDhiaB?= NX7nXpFYS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hTFVzNEWgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5Nige,:jDDHTVUxRTFwOEGg{txO Mkj4NlQ5OzV5OE[=
human SKBR3 cells NUnVbJFnT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlS1OFghcA>? MX;Hdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDTT2JTOyClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUCuO|Qh|ryP MofWNlI5PTB{MUS=

... Click to View More Cell Line Experimental Data

In vivo In this Calu-6 xenograft model, ABT-751 as a single agent at 100 and 75 mg/kg/day shows significant antitumor activity, while in combination with cisplatin, ABT-751 shows a dose-dependent enhancement in growth delay. In the HT-29 colon xenograft model, ABT-751 also shows significant antitumor activity as a single agent and produced a dose-dependent enhancement in growth delay In combination with 5-FU. [2] In dogs with lymphoma, ABT-751 exhibits the dose-limiting toxicities that included vomiting, diarrhea, anorexia, or some combination of these with a maximum tolerated dose (MTD) of 350 mg/m2 PO q24h. Furthermore, the mean AUC and Cmax for ABT-751 at the MTD of 350 mg/m2 is 5.55 μg-hour/mL and 0.9 μg/mL, respectively. [3]

Protocol

Cell Research:[1]
- Collapse
  • Cell lines: HOS, HTB-186 Daoy, TC-71, RD, SK-N-AS, SK-N-DZ, LD and KCNR cells
  • Concentrations: 0 to 100 μM
  • Incubation Time: 72 hours
  • Method: Cells, in 1640 RPMI media with FBS, are plated in triplicate onto 96 well tissue culture plates in numbers determined optimal for confluent monolayer growth (5,000 cells/well for HOS, HTB-186 Daoy; 10,000 cells/well for TC-71, RD, SK-N-AS, SK-N-DZ, LD; 30,000 cells/well for KCNR), with an automated, multichannel pipette system. Cells are incubated for 24 hours at 37 °C/5% CO2 then exposed to vehicle control (1.25% DMSO/H2O), VCR (0.1–1000 nM), ABT-751 (0.1 nM–100 μM), and in 4 cell lines (SK-N-AS, KCNR, RD, TC-71) combretastatin (0.1–1000 nM) for 72 hours. Cells are fixed with trichloroacetic acid (final concentration 10%) at 4 °C, washed, then dried at room temperature, stained with SRB in 1% acetic acid and dye is then solubilized with Tris base. Optical density measurements are performed at 540 and 405 nm dual wavelengths in a Bio-Tek EL 340 UV plate reader.
    (Only for Reference)
Animal Research:[2]
- Collapse
  • Animal Models: Calu-6 NSCLC, HT-29 colon, and HCT-116 cells are injected into athymic mice.
  • Dosages: 75 or 100 mg/kg/day
  • Administration: Administered via p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 74 mg/mL (199.24 mM)
Ethanol 12 mg/mL (32.3 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% propylene glycol, 5% Tween 80, 65% D5W
For best results, use promptly after mixing.
15 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 371.41
Formula

C18H17N3O4S

CAS No. 141430-65-1
Storage powder
in solvent
Synonyms N/A
Smiles COC1=CC=C(C=C1)S(=O)(=O)NC2=C(N=CC=C2)NC3=CC=C(C=C3)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Microtubule Associated Signaling Pathway Map

Related Microtubule Associated Products

Tags: buy ABT-751 (E7010) | ABT-751 (E7010) supplier | purchase ABT-751 (E7010) | ABT-751 (E7010) cost | ABT-751 (E7010) manufacturer | order ABT-751 (E7010) | ABT-751 (E7010) distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID