ABT-751 (E7010)

Catalog No.S1165

ABT-751 (E7010) Chemical Structure

Molecular Weight(MW): 371.41

ABT-751 (E7010) binds to the colchicine site on β-tubulin and inhibits polymerization of microtubules, not a substrate for the MDR transporter and is active against cell lines resistant to vincristine, doxorubicin, and cisplatin. Phase 1/2.

Size Price Stock Quantity  
In DMSO USD 160 In stock
USD 120 In stock
USD 470 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Cited by 2 Publications

3 Customer Reviews

  • Cell viability in H292 monolayer cells after 3-day treatment and spheroid volume in H292 3D culture after 7-day treatment with ABT751. Data points are means ?SD for three individual experiments. IC50 values were calculated to emphasize the differences in drug potency in 2D verses 3D cultures. ABT751, IC50 of 177.2 ?17.3 nM for 2D and 670.2 ?257.6 nM for 3D.

    Bioorg Med Chem 2013 21, 922-31. ABT-751 (E7010) purchased from Selleck.

    3D spheroid integrity following treatment with ABT751. Representative phase contrast imagines of H292 multi-cellular 3D spheroid at the onset of the treatment and after a 7-day treatment interval with various concentrations. Magnification: 10 X objective, scan bar: 200 μm. Dose and time dependent curves of ABT751 with 3D spheroid assay.

    Bioorg Med Chem 2013 21, 922-31. ABT-751 (E7010) purchased from Selleck.

  • Western blot analysiswas used to validate the regulation of β1-tubulin to vinculin. (A) Inhibited effects of ABT-751 on the β1-tubulin.Washed human plateletswere treatedwith 0, 2.5, 5, 10 and 20 μg/ml ABT-751 for 60 min then stimulated with 0.3 U thrombin (B) Protein expression of vinculin and Talin1 in washed platelets. The representative bands were from different gels for repeated experiments. After densitometric analysis, the values of proteins were normalized against GAPDH, respectively. Data are shown as the mean ± S.D. (n =3-4 per group). ##P < 0.01 vs normal group, **P < 0.01 vs thrombin group, ++P < 0.01 vs thrombin group.

    Fitoterapia, 2017, 116:106-115. ABT-751 (E7010) purchased from Selleck.

Purity & Quality Control

Choose Selective Microtubule Associated Inhibitors

Biological Activity

Description ABT-751 (E7010) binds to the colchicine site on β-tubulin and inhibits polymerization of microtubules, not a substrate for the MDR transporter and is active against cell lines resistant to vincristine, doxorubicin, and cisplatin. Phase 1/2.
Features An orally bioavailable tubulin-binding and antimitotic sulfonamide.
Targets
Microtubules [1]
In vitro

In vitro, ABT-751 shows the selective cytotoxicity with IC50 of 0.6–2.6 μM in neuroblastoma and 0.7–4.6 μM in other solid tumor cell lines. Furthermore, ABT-751 also exhibits a selective effect on dynamic microtubules and spares stable microtubules, accounting for the persistence of acetylated and detyrosinated α-tubulin positive polymerized tubules at the IC90 concentration of ABT-751. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HCT-15 cell MkHmVJJwdGmoZYLheIlwdiCjc4PhfS=> MUPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKGOxbH;uJINiemOrbn;tZUBJS1RvMUWgZ4VtdCCuaX7lLG1FWihvKTmsJGlEPTB;MD6zOEDPxE1? NUTBdnYxOTF2MkW1N|Q>
HCT116-C9 cell M1vn[WZ2dmO2aX;uJIF{e2G7 MlW0SYZn\WO2aY\lJINwdmOnboTyZZRqd25idH:gbY5pcWKrdDDj[YxtKHC{b3zp[oVz[XSrb36gZpkhPTBnIILlcIF1cX[nIITvJJVvfHKnYYTl[EBkd262cn;sJINmdGxiYX\0[ZIhPzJiaIKgc4Yh[2:wdHnueY92eyCneIDvd5Vz\SCrbjDIR3QyOTZvQ{mgZ4VtdCCuaX7lMEBKSzVyPUCuPUDPxE1? M2nwN|EzOzh|MEG3
NCI-H460 cell MkC2VJJwdGmoZYLheIlwdiCjc4PhfS=> MVfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKGy3bnegZ4Fz[2mwb33hJG5EUS2KNE[wJINmdGxibHnu[UApVUSUKDupLUwhUUN3ME2wMlM2KM7:TR?= M3u3UFEyPDJ3NUO0
P388 cell line M1nTWGZ2dmO2aX;uJIF{e2G7 Ml7SO|IhcA>? NFPJeVNG\m[nY4TpeoUh[2:wY3XueJJifGmxbjD0c{BqdmirYnn0JINmdGxicILvcIln\XKjdHnvckBjgSB3MDWgdoVt[XSrdnWgeI8hfW62cnXheIVlKGOxboTyc4wh[2WubDDh[pRmeiB5MjDodkBw\iClb370bY52d3W|IHX4dI9{fXKnIHnuJHA{QDhiY3XscEBtcW6n78{MJGlEPTB;MD6xPUDPxE1? NV\FSIJoOTJ|OEOwNVc>
P388/4.0 r-M cell line M3LV[WZ2dmO2aX;uJIF{e2G7 M4nJfFczKGh? MWjF[oZm[3SrdnWgZ49v[2WwdILheIlwdiC2bzDpcohq[mm2IHPlcIwheHKxbHnm[ZJifGmxbjDifUA2OCVicnXsZZRqfmVidH:geY51emWjdHXkJINwdnS{b3ygZ4VtdCCjZoTldkA4OiCqcjDv[kBkd262aX71c5V{KGW6cH;zeZJmKGmwIGCzPFgwPC5yIIKtUUBk\WyuIHzpcoUtKEmFNUC9NVUh|ryP MWCxNlM5OzBzNx?=
human HL60 cells Ml3MVJJwdGmoZYLheIlwdiCjc4PhfS=> M4rxbmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFy2NEBk\WyuczygTWM2OD1yLkO0JO69VQ>? NIHvbZkyPzJ5NkC1Oi=>
HeLa cells M1fCUGN6fG:2b4jpZ4l1gSCjc4PhfS=> NW[4TGtOPDhvN{KgbC=> NWT2Z5E3S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDj[YxteyCjZoTldkA1QCC2bzC3NkBpenNiYomgW2FVNTFiYYPzZZktKEmFNUC9NE4zPyEQvF2= M1vwWlIyOTJ4MEK3
MDR1 cells M2fobWN6fG:2b4jpZ4l1gSCjc4PhfS=> NUDUeoZGPDhvN{KgbC=> MYDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDOR2kuSUSULWLFV{BmgHC{ZYPzbY5oKE2GUkGgZ4VtdHNiYX\0[ZIhPDhidH:gO|IhcHK|IHL5JHdCXC1zIHHzd4F6NCCLQ{WwQVAvOjlizszN MkXyNlEyOjZyMke=
Jurkat cells NEDuVY9HfW6ldHnvckBie3OjeR?= M3rjcVI1KGh? MVzD[YxtKGO7Y3zlJIFzemW|dDDpckBpfW2jbjDKeZJs[XRiY3XscJMh[XO|ZYPz[YQh[XNiYXPjeY12dGG2aX;uJIF1KEd{L12gdIhie2ViYX\0[ZIhOjRiaILzJJV{cW6pIIDyc5Bq\Gm3bTDpc4Rq\GVic4ThbY5qdmdiYomgSmFEWyCjbnHsfZNqeyxiSVO1NF0xNjF4IN88US=> M2THclIyOTJ4MEK3
SW620 cells Mk[wR5l1d3SxeHnjbZR6KGG|c3H5 MnzEOFguPzJiaB?= NW\a[mpHS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW1d4MkCgZ4VtdHNiYX\0[ZIhPDhidH:gO|IhcHK|IHL5JHdCXC1zIHHzd4F6NCCLQ{WwQVAvOTlizszN MoqwNlEyOjZyMke=
A2780 cells MnvLR5l1d3SxeHnjbZR6KGG|c3H5 Mn3QOFguPzJiaB?= M2f3W2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGEzPzhyIHPlcIx{KGGodHXyJFQ5KHSxIEeyJIhzeyCkeTDXRXQuOSCjc4PhfUwhUUN3ME2wMlE4KM7:TR?= NGLRTWwzOTF{NkCyOy=>
HT-29 cells NGnWSVRRem:uaX\ldoF1cW:wIHHzd4F6 MkSxO|IhcA>? MlGwRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKVD2yPUBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTBwMkGg{txO NXu4d2wzOjN{MEK4OFk>
HUVEC NXHnNXZFTnWwY4Tpc44h[XO|YYm= NHG3dm8yODBvMUCwNEBvVQ>? MlryOEBp NFHwWGRKdmS3Y4Tpc44hd2ZidnHzZ5Vt[XJiZHnzdpVxfGmwZzDhZ5Rqfmm2eTDpckBJXV[HQzDhd5Nme3OnZDDhd{BXTUeILXnu[JVk\WRidIXi[UBnd3KvYYTpc44h[XRiMUCwJJRwKDFyMECgcm0h[W[2ZYKgOEBpenNiYomgcYlkem:|Y3;wbYMh[W6jbInzbZM> MV[yOFExPjl6Mh?=
H460 cells M333SGN6fG:2b4jpZ4l1gSCjc4PhfS=> Mn3DO|IhcA>? NY\hd285S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUDR4MDDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nlibXX0bJlt\W6nIHLseYUhe3SjaX7pcocu[mG|ZXSgZZN{[XluIFnDOVA:OC5{MUe3JO69VQ>? MWCyOFExPjl6Mh?=
MKN45 cells MlHIR5l1d3SxeHnjbZR6KGG|c3H5 M3rVfVczKGh? NVzIdHV5S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUuQNEWgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IH3leIh6dGWwZTDicJVmKHO2YXnubY5oNWKjc3XkJIF{e2G7LDDJR|UxRTBwMU[2JO69VQ>? M3zX[VI1OTB4OUiy
HT-29 cells NYntbVVXS3m2b4TvfIlkcXS7IHHzd4F6 NX;JWFFVPzJiaB?= M360e2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhVNTJ7IHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSCvZYTofYxmdmViYnz1[UB{fGGrbnnu[{1j[XOnZDDhd5NigSxiSVO1NF0xNjN|OEeg{txO NGn5UHozPDFyNkm4Ni=>
human A549 cells NX3XPWptS3m2b4TvfIlkcXS7IHHzd4F6 MofOOFghcA>? NWnDTZNFS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVEvOzFizszN NFe1eIczPDh|NUe4Oi=>
ACHN cells NFnN[3dEgXSxdH;4bYNqfHliYYPzZZk> M{G4e|Q5KGh? MnXpR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRWNJViClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUKuNVMh|ryP NHzBc5QzPDh|NUe4Oi=>
MCF7 cells MULDfZRwfG:6aXPpeJkh[XO|YYm= NUDLVYFJPDhiaB?= NF;CUHFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUC9NU4zPSEQvF2= NULiU4U1OjR6M{W3PFY>
HT-29 cells M4jk[GN6fG:2b4jpZ4l1gSCjc4PhfS=> NXjLTnZSPDhiaB?= NFjycHdEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJXC1{OTDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVEvPjJizszN MVWyOFg{PTd6Nh?=
A549 cells M2TpVXBzd2yrZnXyZZRqd25iYYPzZZk> NWnMfGJ[OjRiaB?= NInZR2hCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG1OFkh[2WubIOgZZN{\XO|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgNlQhcHK|IHL5JHNTSiCjc4PhfUwhT0l3ME2xMlMyKM7:TR?= MVKyOVQ3QDB|OR?=
human MCF7 cells MYLQdo9tcW[ncnH0bY9vKGG|c3H5 MYeyOEBp NWG4XpRqSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFI1KGi{czDifUBUWkJiYYPzZZktKEeLNUC9NU4zPSEQvF2= NUPmTYhrOjV2NkiwN|k>
KB-S15 cells NVjhflhSS3m2b4TvfIlkcXS7IHHzd4F6 NXS4foZlPzJiaB?= MoLTR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT2IuWzF3IHPlcIx{KG:4ZYLlfJBz\XO|aX7nJHAu\3BzN{CvUWRTKGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSCvZYTofYxmdmViYnz1[UB{fGGrbnnu[{1j[XOnZDDhd5NigSxiSVO1NF0xNjJyNjFOwG0> MnHJNlQyODZ7OEK=
KB-7d cells NILIV41EgXSxdH;4bYNqfHliYYPzZZk> MkTVO|IhcA>? MnnaR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT2IuP2RiY3XscJMhd3[ncnX4dJJme3OrbnegUXJRKGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSCvZYTofYxmdmViYnz1[UB{fGGrbnnu[{1j[XOnZDDhd5NigSxiSVO1NF0xNjJyNTFOwG0> M{T5SlI1OTB4OUiy
KB-VIN10 cells MYnDfZRwfG:6aXPpeJkh[XO|YYm= MVm3NkBp NEjab2VEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMSi2YSV6xNEBk\WyuczDveoVz\XiycnXzd4lv\yCSLXfwNVcxN02GUjDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgcYV1cHmuZX7lJIJtfWVic4ThbY5qdmdvYnHz[YQh[XO|YYmsJGlEPTB;MD6yNlch|ryP M2ToSlI1OTB4OUiy
human PC3 cells MUnDfZRwfG:6aXPpeJkh[XO|YYm= NEjjfZM1QCCq Mny0R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVGM{KGOnbHzzJIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFQ5KGi{czDifUB{fWyob4Loc4RidWmwZTDCJIF{e2G7LDDHTVUxRTBwNkKg{txO M3;Ue|I3OjRzMEOy
human AsPC1 cells MV3DfZRwfG:6aXPpeJkh[XO|YYm= MkTxOFghcA>? MnnSR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRZNRSzFiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPDhiaILzJIJ6KHO3bH\vdohw\GGvaX7lJGIh[XO|YYmsJGdKPTB;ND6xNUDPxE1? NYTDN4lPOjZ{NEGwN|I>
human A549 cells M{LOPWN6fG:2b4jpZ4l1gSCjc4PhfS=> M3\oR|Q5KGh? NHTmOIZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDR6IHjyd{BjgSC|dXzmc5Jpd2SjbXnu[UBDKGG|c3H5MEBIUTVyPUWuN|Mh|ryP MUCyOlI1OTB|Mh?=
Hep3B cells M17IOGN6fG:2b4jpZ4l1gSCjc4PhfS=> MXW0PEBp NYS4dXAzS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyM1KgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiNEigbJJ{KGK7IIP1cIZwemixZHHtbY5mKEJiYYPzZZktKEeLNUC9NE45PCEQvF2= NXHhRmZ2OjZ{NEGwN|I>
KB cells MYPDfZRwfG:6aXPpeJkh[XO|YYm= MYq3NkBp NWDhSlFGS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hU0JiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KG2ndHj5cIVv\SCkbIXlJJN1[WmwaX7nMYJie2WmIHHzd4F6NCCLQ{WwQVAvOjVzMzFOwG0> NH7DSI0zPDFyNkm4Ni=>
DU145 cells NFfVWG9Rem:uaX\ldoF1cW:wIHHzd4F6 NHjvbpAzPCCq NX;5SHhzSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDEWVE1PSClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkAzPCCqcoOgZpkhW1KEIHHzd4F6NCCJSUWwQVEvQDFizszN MoC4NlU1PjhyM{m=
DU145 cells MkHrR5l1d3SxeHnjbZR6KGG|c3H5 NUTGXFZGPDhiaB?= M{fESmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGRWOTR3IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZnwxIxiR1m1NF0yNjhzIN88US=> MoXSNlQ5OzV5OE[=
human SKBR3 cells M4PxUGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Ml\4OFghcA>? MUXHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDTT2JTOyClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUCuO|Qh|ryP M{XRRlIzQDVyMkG0

... Click to View More Cell Line Experimental Data

In vivo In this Calu-6 xenograft model, ABT-751 as a single agent at 100 and 75 mg/kg/day shows significant antitumor activity, while in combination with cisplatin, ABT-751 shows a dose-dependent enhancement in growth delay. In the HT-29 colon xenograft model, ABT-751 also shows significant antitumor activity as a single agent and produced a dose-dependent enhancement in growth delay In combination with 5-FU. [2] In dogs with lymphoma, ABT-751 exhibits the dose-limiting toxicities that included vomiting, diarrhea, anorexia, or some combination of these with a maximum tolerated dose (MTD) of 350 mg/m2 PO q24h. Furthermore, the mean AUC and Cmax for ABT-751 at the MTD of 350 mg/m2 is 5.55 μg-hour/mL and 0.9 μg/mL, respectively. [3]

Protocol

Cell Research:[1]
- Collapse
  • Cell lines: HOS, HTB-186 Daoy, TC-71, RD, SK-N-AS, SK-N-DZ, LD and KCNR cells
  • Concentrations: 0 to 100 μM
  • Incubation Time: 72 hours
  • Method: Cells, in 1640 RPMI media with FBS, are plated in triplicate onto 96 well tissue culture plates in numbers determined optimal for confluent monolayer growth (5,000 cells/well for HOS, HTB-186 Daoy; 10,000 cells/well for TC-71, RD, SK-N-AS, SK-N-DZ, LD; 30,000 cells/well for KCNR), with an automated, multichannel pipette system. Cells are incubated for 24 hours at 37 °C/5% CO2 then exposed to vehicle control (1.25% DMSO/H2O), VCR (0.1–1000 nM), ABT-751 (0.1 nM–100 μM), and in 4 cell lines (SK-N-AS, KCNR, RD, TC-71) combretastatin (0.1–1000 nM) for 72 hours. Cells are fixed with trichloroacetic acid (final concentration 10%) at 4 °C, washed, then dried at room temperature, stained with SRB in 1% acetic acid and dye is then solubilized with Tris base. Optical density measurements are performed at 540 and 405 nm dual wavelengths in a Bio-Tek EL 340 UV plate reader.
    (Only for Reference)
Animal Research:[2]
- Collapse
  • Animal Models: Calu-6 NSCLC, HT-29 colon, and HCT-116 cells are injected into athymic mice.
  • Formulation: ABT-751 is dissolved 4% ethanol/96% dextrose solution (D5W) with 1 eq. 1 N HCl.
  • Dosages: 75 or 100 mg/kg/day
  • Administration: Administered via p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 74 mg/mL (199.24 mM)
Ethanol 12 mg/mL (32.3 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% propylene glycol, 5% Tween 80, 65% D5W
For best results, use promptly after mixing.
15 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 371.41
Formula

C18H17N3O4S

CAS No. 141430-65-1
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Microtubule Associated Signaling Pathway Map

Related Microtubule Associated Products

Tags: buy ABT-751 (E7010) | ABT-751 (E7010) supplier | purchase ABT-751 (E7010) | ABT-751 (E7010) cost | ABT-751 (E7010) manufacturer | order ABT-751 (E7010) | ABT-751 (E7010) distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID