All Products

Catalog No. Product Name Information
S3897 (-)-Arctigenin (-)-Arctigenin, a lignan found in certain plants of the Asteraceae, exerts biological activities including anti-inflammatory, antiviral and anticancer.
S1671 (6-)ε-​Aminocaproic acid (6-)ε-​Aminocaproic acid is a derivative and analogue of the amino acid lysine.
P1212 (Ala13)-Apelin-13

(Ala13)-Apelin-13 is a potent APJ receptor antagonist and can prevent the apelin-induced reduction in gastric tone and motility.

S6886 1-Aminobenzotriazole 1-Aminobenzotriazole (ABT, 3-Aminobenzotriazole, 1-Benzotriazolylamine, NSC 114498, NSC 656987) is a nonselective and irreversible inhibitor of cytochrome P450 (CYP) enzymes. 1-Aminobenzotriazole is also a substrate and inhibitor of N-acetyltransferase (NAT).
S7193 1-Azakenpaullone 1-Azakenpaullone (1-Akp) is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, >100-fold selectivity over CDK1/cyclin B and CDK5/p25.
S0397 1588-A4 1588-A4 (ARS-1620 Intermediate) is the ARS-1620 intermediate. ARS-1620 is an atropisomeric selective KRASG12C inhibitor with desirable pharmacokinetics.
E0197 2-Acetamidofluorene

2-Acetamidofluorene (2-AAF, 2-Acetaminofluorene, N-2-Fluorenylacetamide, N-Acetyl-2-aminofluorene) is a carcinogenic and mutagenic compound.

S5304 2-Acetylphenothiazine (ML171) 2-Acetylphenothiazine (ML171, 2-APT) is a potent and selective inhibitor of NADPH-oxidase with IC50s of 0.25 μM, 5 μM, 3μM, 5 μM and 5.5 μM for NOX1, NOX2, NOX3, NOX4 and xanthine oxidase, respectively.
S6261 2-Acetylpyrazine 2-Acetylpyrazine is one of the volatile flavor constituents in popcorn, wheat and rye bread crust.
S3135 2-Amino-1-phenylethanol

2-Amino-1-phenylethanol (2-APE) is a noradrenaline analogue.

S0132 2-Amino-N-quinolin-8-yl-benzenesulfonamide (NUN82647) 2-Amino-N-quinolin-8-yl-benzenesulfonamide (NUN82647, QBS, CU-242) is an inhibitor of cell cycle at G2 phase and apoptosis inducer.
E0416 2-Aminoacridone

2-Aminoacridone is a highly fluorescent aromatic.

S4998 2-Aminobenzenesulfonamide 2-Aminobenzenesulfonamide (Orthanilamide, O-Aminobenzenesulfonamide, O-Sulfanilamide, Benzenesulfonamide) is an inhibitor of carbonic anhydrase IX.
S6032 2-Aminobenzenesulfonic acid 2-Aminobenzenesulfonic acid (Orthanilic acid, O-Aminobenzenesulfonic acid, Aniline-2-sulfonic acid) is a biological acid with roles in benzoate degradation and microbial metabolism in diverse environments.
S6402 2-Aminoethanethiol 2-Aminoethanethiol (cysteamine, β-Mercaptoethylamine, 2-Mercaptoethylamine, Thioethanolamine, Mercaptamine) is a radiation-protective agent that oxidizes in air to form cystamine.
S6657 2-Aminoethyl Diphenylborinate (2-APB) 2-Aminoethyl Diphenylborinate (2-APB) is an IP3 receptor inhibitor and regulate IP3-induced calcium release.2-APB also inhibits the SOC channel activity and activates TRP channel at higher concentrations.
S3331 2-Aminoethylphosphonic acid

2-Aminoethylphosphonic acid (2-AEP, (2-Aminoethyl)phosphonic acid) is a type of abundant and ubiquitous naturally occurring phosphonate used as sources of phosphorus by many prokaryotic lineages.

S4520 2-Aminoheptane 2-Aminoheptane (Tuaminoheptanez, Tuamine, Heptamine, 1-Methylhexylamine, 2-Heptylamine) is a nasal decongestant drug which is a sympathomimetic stimulant and vasoconstrictor.
S6270 2-Aminoisobutyric acid 2-Aminoisobutyric acid (NSC-16590, 2-Methylalanine, H-Aib-OH) is a rare, non-protein amino acid and end-product of pyrimidine metabolism, excreted in urine and found in some antibiotics of fungal origin.
S5977 3-Amino-1,2,4-triazole 3-Amino-1,2,4-triazole (1,2,4-Triazol-3-amine, 3-AT, Aminotriazole, Amitrol, 3-Amino-1H-1,2,4-triazole, Trapidil impurity B) is a common irreversible inhibitor of catalase, induces a compensatory mechanism for the hydrogen peroxide detoxification, which includs a rise in glutathione peroxidase (GPX) and glutathione reductase activities.
S6361 3-Amino-4-hydroxybenzoic acid 3-Amino-4-hydroxybenzoic acid is a monohydroxybenzoic acid.
S6142 3-Amino-4-methylpentanoic acid 3-Amino-4-methylpentanoic acid (beta-Leucine, DL-Homovaline, DL-beta-leucine, beta-Aminoisocaproic acid) is a human metabolite.
S1132 3-Aminobenzamide 3-Aminobenzamide (3-ABA , 3-Amino Benzamide, 3-AB) is a potent inhibitor of Poly(ADP-ribose)polymerase (PARP) and inhibits cell apoptosis after SCI (Spinal Cord Injury) in caspase-independent way.
S6134 3-Aminoisobutyric acid 3-Aminoisobutyric acid (3-Amino-2-methylpropanoic acid, 3-Aminoisobutyrate, β-aminoisobutyric acid) is a product formed by the catabolism of thymine.
S5340 3-Aminopropionitrile fumarate 3-Aminopropionitrile fumarate (Beta-Aminopropionitrile fumarate) is an organic compound and antirheumatic agent used in veterinary medicine.
S3358 4-Acetamidobutyric acid

4-Acetamidobutanoic acid (N-acetyl GABA) is a derivative of Gamma-aminobutyric acid (GABA) resulting from the monoacetylation of the nitrogen of GABA.

S5339 4-Allylanisole 4-Allylanisole (Estragole, p-Allylanisole, Methyl chavicol) is a natural organic compound that is a component of various trees and plants. It is used in the preparation of fragrances.
S4509 4-Aminoantipyrine 4-Aminoantipyrine(Ampyrone) is a metabolite of aminopyrine with analgesic, anti-inflammatory, and antipyretic properties. It is used as a reagent for biochemical reactions producing peroxides or phenols.
S9874 4-Aminobenzohydrazide 4-Aminobenzohydrazide (4-Aminobenzhydrazide, 4-aminobenzoic acid hydrazide, 4-ABAH, Myeloperoxidase Inhibitor I, NSC 640) is an inhibitor of MPO (Myeloperoxidase) enzyme that enhances iNOS induction in MPO-positive cells, but not in MPO-KO cells.
S4510 4-Aminobenzoic acid 4-Aminobenzoic acid (para-Aminobenzoic acid) is an intermediate in the synthesis of tetrahydrofolic acid in many non-mammalian organisms, including bacteria and fungi.
S4700 4-Aminobutyric acid (GABA) 4-Aminobutyric acid (4-Aminobutanoic acid, GABA, Gamma-aminobutyric acid, Piperidic acid) is a naturally occurring neurotransmitter with central nervous system (CNS) inhibitory activity.
S5509 4-Aminophenol 4-aminophenol (p-aminophenol) is a metabolite of compounds such as acetaminophen (paracetamol) and azo dyes that has been shown to be toxic to mammalian cells.
S5099 4-Aminophenylarsonic acid 4-Aminophenylarsonic acid (Arsanilic Acid) is an organoarsenic compound with activity as an anti-infective agent.
S5028 4-Aminopyridine 4-Aminopyridine (4-AP, Fampridine, Dalfampridine) is a potent and non-selective inhibitor of voltage gated potassium channels (Kv) with IC50 values of 170 μM and 230 μM for Kv1.1 and Kv1.2 in CHO cells, respectively.
S5211 4-Aminosalicylic acid 4-Aminosalicylic acid (Para-aminosalicylic acid, Aminosalicylic acid, 4-aminosalicylate) is an antitubercular agent with bacteriostatic activity against Mycobacterium tuberculosis.
S9366 5'-Adenylic acid AMP, also known as 5'-Adenylic acid and Adenosine monophosphate, is a nucleotide that is found in RNA. It is used as a dietary supplement to boost immune activity, and is also used as a substitute sweetener to aid in the maintenance of a low-calorie diet.
S4789 5-Acetylsalicylic acid 5-Acetylsalicylic acid (5-acetyl-2-hydroxybenzoic acid) is a nonsteroidal anti-inflammatory drug.
E1087 5-amino-2,4-dimethylpyridine (5A-DMP)

5-amino-2,4-dimethylpyridine (5A-DMP) is a novel tandem Tudor domain (TTD)-binding compound that inhibits the full-length UHRF1:LIG1 interaction in Xenopus egg extracts.

S2553 5-Aminolevulinic acid HCl 5-Aminolevulinic Acid HCl is an intermediate in the porphyrin synthesis pathway, used as a photosensitizing agent and a antineoplastic agent.
S3206 5a-Pregnane-3,20-dione 5a-Pregnane-3,20-dione (5alphaP, 5-a-dihydroprogesterone, 3,20-allopregnanedione, 5-Alpha-Dihydro Progesterone) is the endogenous progesterone metabolite. 5a-Pregnane-3,20-dione depolymerizes actin and decreases expression of actin and vinculin. 5a-Pregnane-3,20-dione is involved in promoting breast neoplasia and metastasis by affecting adhesion and cytoskeletal molecules.
S5125 5alpha-Cholestan-3-one 5alpha-Cholestan-3-one (Coprostanone) is a substrate of cholestenone 5alpha-reductase.
S4534 6-Acetamidohexanoic acid 6-Acetamidohexanoic acid (6-Acetamidocaproic acid) is a pharmaceutical intermediate.
S9783 6-Aminonicotinamide 6-Aminonicotinamide (6AN) is an antimetabolite used to inhibit the NADPH-producing pentose phosphate pathway (PPP) in many cellular systems, making them more susceptible to oxidative stress. 6-Aminonicotinamide is a competitive inhibitor of NADP+-dependent enzyme glucose-6-phosphate dehydrogenase (G6PD) with Ki of 0.46 μM.
S5035 6-Aminopenicillanic acid 6-Aminopenicillanic acid (6-APA) is the central component of penicillin β-lactam antibiotics which are generated by Penicillium. It is used as precursor for antibiotic compounds ampicillin and amoxicillin.
S2530 7-Aminocephalosporanic acid 7-Aminocephalosporanic acid is used for synthesis of cephalosporin antibiotics and intermediates.
S6732 7ACC2 7ACC2 is a potent inhibitor of mitochondrial pyruvate transport 1 (MCT1) with an IC50 value of 10 nM for lactate uptake in SiHa human cervix carcinoma cells.
S6082 8-Aminooctanoic acid 8-Aminooctanoic acid is a chemical.
S2653 9-amino-CPT (9-Aminocamptothecin) 9-amino-CPT (9-Aminocamptothecin, 9-AC, Aminocamptothecin, 9-amino-20(S)-camptothecin) is a Topoisomerase I inhibitor with potent anticancer activities. 9-amino-CPT (9-Aminocamptothecin) is an active, water-insoluble derivative of camptothecin.
S4303 9-Aminoacridine 9-Aminoacridine (Aminacrine) is a highly fluorescent dye used clinically as a topical antiseptic and experimentally as a mutagen, an intracellular pH indicator and a negative mode small molecule MALDI matrix.
S3545 A 77-01 A 77-01 is a potent inhibitor of TGF-β1 receptor ALK5 with IC50 of 25 nM.
S7800 A-1155463 A-1155463, a highly potent and selective BCL-XL inhibitor, shows picomolar binding affinity to BCL-XL, and >1000-fold weaker binding to BCL-2 and related proteins BCL-W(Ki=19 nM) and MCL-1(Ki>440 nM).
S7801 A-1331852 A-1331852 is a potent and selectiveBCL-XL inhibitor with Ki value less than 0.01 nM for BCL-XL and 6 nM, 4 nM, 142 nM for Bcl-2, Bcl-W, MCL-1 respectively. It may be useful in the treatment of cancer, immune and autoimmune diseases.
S8519 A-317491 A-317491 is a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors with Ki values of 22 nM and 9 nM for human P2X3 and P2X2/3 receptors.
S0731 A-381393 A-381393 is a potent, selective, brain-penetrate antagonist of dopamine D4 receptor with Ki of 1.5 nM, 1.9 nM and 1.6 nM for human dopamine D4.4, D4.2 and D4.7 receptor, respectively. A-381393 shows moderate affinity for 5-HT2A with Ki of 370 nM.
S8740 A-485 A-485 is a potent, selective and drug-like p300/CBP catalytic inhibitor with an IC50 of 0.06 μM for p300 HAT. It is selective over BET bromodomain proteins and >150 non-epigenetic targets.
S0826 A-740003 A-740003 is a potent, selective and competitive antagonist of P2X7 receptor with IC50 of 18 nM and 40 nM for rat and human P2X7 receptors, respectively. A-740003 potently blocks agonist-evoked IL-1β release and pore formation with IC50 of 156 nM and 92 nM in differentiated human THP-1 cells.
S2697 A-769662 A-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM in cell-free assays, little effect on GPPase/FBPase activity.
E0039 A-779

A-779 is a potent and selective antagonist for Angiotensin-(1–7) (Ang-(1-7)) with an IC50 of 0.3 nM in a radioligand binding assay. A-779 shows no significant affinity for AT1 or AT2 receptors at a concentration of 1 μM.

S2785 A-803467 A-803467 is a selective NaV1.8 channel blocker with IC50 of 8 nM, blocks tetrodotoxin-resistant currents, exhibits >100-fold selectivity against human NaV1.2, NaV1.3, NaV1.5, and NaV1.7.
S7692 A-83-01 A-83-01 is a potent inhibitor of TGF-β type I receptor (ALK5-TD) with IC50 of 12 nM. A-83-01 also inhibits the transcription induced by activin/nodal type I receptor (ALK4-TD) and nodal type I receptor (ALK7-TD) with IC50 of 45 nM and 7.5 nM, respectively.Solutions are best fresh-prepared.
A5087 A-RAF Rabbit Recombinant mAb A-RAF Rabbit Recombinant mAb detects endogenous levels of total A-RAF.
S0988 A1120 A1120 is an antagonist of retinol-binding protein 4 (RBP4) with Ki of 8.3 nM. A1120 disrupts the interaction between RBP4 and its binding partner transthyretin.
S8785 A1874 A1874 is a much improved nutlin-based, BRD4-degrading PROTAC and is able to degrade its target protein by 98% with nanomolar potency.
S0741 A2764 dihydrochloride A2764 dihydrochloride is a selective inhibitor of TRESK (TWIK-related spinal cord K+ channel, K2P18.1) with IC50 of 11.8 μM for the activated mTRESK channel. A2764 dihydrochloride has the potential for probing the role of TRESK channel in migraine and nociception.
S0524 A2793 A2793 (Ethyl [(5-Chloroquinolin-8-yl)oxy]acetate) is an efficient inhibitor of TWIK-related spinal cord potassium channel (TRESK, K2P18, KCNK18) and TASK-1 (KCNK3) with IC50 of 6.8 μM for mouse TRESK.
S3408 A286982 A-286982 is a potent, nonpeptide inhibitor of LFA-1/ICAM-1 interaction with IC50s of 44 nM and 35 nM in an LFA-1/ICAM-1 binding assay and LFA-1-mediated cellular adhesion assay, respectively.
S2674 A922500 A922500 (DGAT-1 Inhibitor 4a) is an inhibitor for human and mouse DGAT-1 with IC50 of 7 nM and 24 nM, respectively, good selectivity over related acyltransferases, hERG, and a panel of anti-targets.
S9607 A939572 A939572 is a potent and orally bioavailable stearoyl-CoA desaturase1 (SCD1) inhibitor with IC50 of <4 nM and 37 nM for mSCD1 and hSCD1, respectively.
S0286 AA26-9 AA26-9 is a potent and broad spectrum inhibitor of Serine hydrolases (SHs).
E0409 AA38-3

AA38-3 is a serine hydrolase (SH) inhibitor that inhibits three SHs, ABHD6, ABHD11, and FAAH.

S3489 AA41612 AA41612 is an antagonist of melanopsin-mediated phototransduction.
S3415 AA92593 AA92593 is a selective antagonist of Melanopsin (OPN4) which is a photo-pigment found in a small subset of intrinsically photosensitive ganglion cells (ipRGCs) of the mammalian retina.
S0038 AB-423 AB-423, a member of the sulfamoylbenzamide (SBA) class of hepatitis B virus (HBV) capsid inhibitors, shows potent inhibition of HBV replication with EC50 of 0.08 μM - 0.27 μM and EC90 of 0.33 μM - 1.32 μM in cells. Phase 1.
S5215 Abacavir (1592U89) Abacavir (1592U89, ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS.
S3165 Abacavir sulfate Abacavir (1592U89) is a commonly used nucleoside analogue with potent antiviral activity against HIV-1.
P1092 Abaloparatide (BA058)

Abaloparatide (BA058, BIM-44058, ITM-058) is a novel 34-amino acid peptide selected to be a potent and selective activator of the parathyroid hormone receptor (PTH1R) signaling pathway with an IC50 of 0.117 nM in SOST analysis.

S5752 Abametapir Abametapir (HA-44, BRN 0123183), the active ingredient of Xeglyze Lotion, is an inhibitor of metalloproteinases critical for louse survival and egg development.
P1091 Abatacept Abatacept (Orencia, CTLA4lg, BMS-188667) is a recombinant DNA generated fusion protein that comprises the extracellular domain of human CTLA-4 fused to the Fc portion of human IgG1 and antagonizes CD28-mediated T cells.
S8723 ABBV-744 ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2, BRD3 and BRD4. It is developed for treating AML and cancers.
A5343 ABCF1 Rabbit Recombinant mAb ABCF1 Rabbit Recombinant mAb detects endogenous level of total ABCF1.
S5716 Abemaciclib (LY2835219) Abemaciclib (LY2835219) is a cell cycle inhibitor selective for CDK4/6 with IC50 of 2 nM and 10 nM in cell-free assays, respectively.
S7158 Abemaciclib mesylate (LY2835219) Abemaciclib (LY2835219) is a potent and selective inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM in cell-free assays, respectively. Phase 3.
S1090 Abexinostat (PCI-24781) Abexinostat (PCI-24781, CRA-024781) is a novel pan-HDAC inhibitor mostly targeting HDAC1 with Ki of 7 nM, modest potent to HDACs 2, 3, 6, and 10 and greater than 40-fold selectivity against HDAC8. Phase 1/2.
S5122 Abietic Acid Abietic acid (Sylvic acid, Abietate, Rosin Acid), an abietane diterpenoid, inhibited soybean 5-lipoxygenase with an IC50 of 29.5 ± 1.29 μM.
S1123 Abiraterone (CB-7598) Abiraterone (CB-7598) is a potent CYP17 inhibitor with IC50 of 2 nM in a cell-free assay. Abiraterone (CB-7598) is an androgen biosynthesis inhibitor.
S2246 Abiraterone Acetate (CB7630) Abiraterone Acetate (CB7630) is an acetate salt form of Abiraterone which is a steroidal cytochrome CYP17 inhibitor with IC50 of 72 nM in a cell-free assay. Abiraterone acetate is an oral androgen biosynthesis inhibitor.
S8765 Abrocitinib (PF-04965842) Abrocitinib (PF-04965842) is a potent JAK1 inhibitor with IC50s of 29 nM, 803 nM, > 10 000 nM and 1250 nM for JAK1, JAK2, JAK3 and tyrosine kinase (TYK) 2, respectively.
S7594 Abscisic Acid (Dormin) Abscisic Acid (Dormin, Abscisin II) is a plant hormone, which is involved in many plant developmental processes, modulates ion homeostasis and metabolism, and inhibits germination and seedling growth.
S3288 Absinthin Absinthin (Absynthine) is a naturally produced triterpene lactone from Artemisia absinthium with anti-inflammatory properties. Absinthin significantly enhances the expression of matrix metalloproteinase-8 (MMP-8) and is a possible treatment candidate for Acute lung injury (ALI).
S6619 ABT 702 dihydrochloride ABT-702 is a novel, potent non-nucleoside Adenosine kinase inhibitor with an IC50 of 1.7 nM. It has oral activity in animal models of pain and inflammation.
S0538 ABT-724 ABT-724 is a potent and highly selective agonist of dopamine D4 receptor with EC50 of 12.4 nM, 14.3 nM and 23.2 nM for human dopamine D4 receptor, rat D4 and the ferret D4 receptor, respectively. ABT-724 has no effect on dopamine D1, D2, D3, or D5 receptors. ABT-724 is useful for the treatment of erectile dysfunction and has favorable side-effect profile.
S0537 ABT-724 trihydrochloride ABT-724 trihydrochloride is a potent and highly selective agonist of dopamine D4 receptor with EC50 of 12.4 nM, 14.3 nM and 23.2 nM for human dopamine D4 receptor, rat D4 and the ferret D4 receptor, respectively. ABT-724 trihydrochloride has no effect on dopamine D1, D2, D3, or D5 receptors. ABT-724 trihydrochloride is useful for the treatment of erectile dysfunction and has favorable side-effect profile.
S1002 ABT-737 ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM in cell-free assays, respectively; no inhibition observed against Mcl-1, Bcl-B or Bfl-1. ABT-737 induces mitochondrial pathway apoptosis and mitophagy. Phase 2.
S1165 ABT-751 (E7010) ABT-751 (E7010) binds to the colchicine site on β-tubulin and inhibits polymerization of microtubules, not a substrate for the MDR transporter and is active against cell lines resistant to vincristine, doxorubicin, and cisplatin. Phase 1/2.
S9611 ABTL-0812 ABTL0812 (α-Hydroxylinoleic acid, LP-10218, SCLN-0812) inhibits Akt/mTOR axis by inducing the overexpression of TRIB3 and activating autophagy in lung squamous carcinoma cell lines. ABTL0812 also induces AMPK activation and ROS accumulation.
S8823 ABX-1431 ABX-1431 is a highly potent, selective, and CNS-penetrant Monoacylglycerol lipase (MGLL) inhibitor with IC50 values of 14 nM and 27 nM for hMGLL and mMGLL respectively.
S0076 ABX464 ABX464 (SPL-464) is a novel anti-HIV molecule that inhibits HIV-1 replication in stimulated peripheral blood mononuclear cells (PBMCs) from 5 different donors with IC50 ranging between 0.1 μM and 0.5 μM.
S6354 Ac-Arg-OH Ac-Arg-OH (N-Acetyl-L-arginine) is one of the guanidino compounds found elevated in the serum of an hemodialyzed renal insufficient (uremic) pediatric population.
S7901 Ac-DEVD-CHO Ac-DEVD-CHO (Caspase-3 Inhibitor I, N-Ac-Asp-Glu-Val-Asp-CHO) is a potent aldehyde inhibitor of Group II caspases with Ki values of 0.2 nM and 0.3 nM for for caspase-3 and caspase-7, respectively. Weak inhibition for caspase-2.
S9817 Ac-FLTD-CMK Ac-FLTD-CMK is a specific inhibitor for inflammatory caspases. Ac-FLTD-CMK inhibits gasdermin D (GSDMD) cleavage by caspases-1, -4, -5, and -11 in vitro. Ac-FLTD-CMK is effective against caspases-1, caspases-4 and caspases-5 with IC50 of 46.7 nM, 1.49 μM and 329 nM, respectively.
S0977 AC1903 AC1903 (compound 2) is a specific and selective TRPC5 (transient receptor potential canonical channel 5) inhibitor with IC50 of 4.06 μM.
S1056 AC480 (BMS-599626) AC480 (BMS-599626) is a selective and efficacious inhibitor of HER1 and HER2 with IC50 of 20 nM and 30 nM, ~8-fold less potent to HER4, >100-fold to VEGFR2, c-Kit, Lck, MET etc. Phase 1.
E0055 AC710

AC710 is a potent PDGFR family inhibitor with IC50s of 1.2 nM, 2 nM, 7.7 nM and 10.5 nM for KIT, FLT3, PDGFRβ and CSF1R respectively. AC710 exhibits >30-fold selectivity over a panel of other kinases and exhibits no activity against cytochrome P450.

S5318 Acacetin Acacetin (Linarigenin, 5,7-dihydroxy-4'-methoxyflavone, 4'-Methoxyapigenin) is a flavonoid compound that has been shown to have anti-cancer, anti-mutagenic, anti-inflammatory and anti-peroxidative effects.
S8116 Acalabrutinib (ACP-196) Acalabrutinib (ACP-196) is a selective second-generation Bruton's tyrosine kinase (BTK) inhibitor with an IC50 of 3 nM, which prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. ACP-196 has improved target specificity over ibrutinib with 323-, 94-, 19- and 9-fold selectivity over the other TEC kinase family members (ITK, TXK, BMX, and TEC, respectively) and no activity against EGFR.
S5818 acalisib (GS-9820) Acalisib (GS-9820, CAL-120) is a highly selective and potent p110δ inhibitor (IC50 = 14 nM) with 114- to 400-fold selectivity over the other class I PI3K enzymes and no activity against Class II and III PI3K family members or other PI3K-related proteins including mTOR and DNA-PK.
S3748 Acamprosate Calcium Acamprosate (N-Acetylhomotaurine, Calcium acetylhomotaurinate), is a synthetic compound with a chemical structure similar to the amino acid neurotransmitter gamma-aminobutyric acid (GABA) and the amino acid neuromodulator taurine.
S1271 Acarbose Acarbose(BAY g 5421) is an inhibitor of intestinal alpha-glucosidase, used to treat type 2 diabetes mellitus.
S9612 ACBI1 ACBI1 is a potent and cooperative PROTAC degrader of SMARCA2, SMARCA4 and PBRM1 with DC50 of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 induces anti-proliferative effects and apoptosis.
S4010 Acebutolol HCl Acebutolol is a β-adrenergic receptors antagonist used in the treatment of hypertension, angina pectoris and cardiac arrhythmias.
S4835 Aceclofenac Aceclofenac (Preservex, Airtal) is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties.
S4512 Aceglutamide Aceglutamide (α-N-Acetyl-L-glutamine, N2-Acetylglutamine) is a psychostimulant, nootropic agent which functions as a prodrug to glutamine with improved potency and stability.
S9649 Acelarin (NUC-1031) Acelarin (NUC-1031, Fosgemcitabine palabenamide, CPF-31, MTL-007, GTPL7389), a prodrug based on an aryloxy phosphoramidate derivative of gemcitabine, is a DNA synthesis inhibitor with EC50 of 0.2 nM.
S2602 Acemetacin Acemetacin (K-708) is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.
S2884 Acesulfame Potassium Acesulfame potassium is a non-nutritive sweetener.
S6011 Acetamide Acetamide (ethanamide, Acetic acid amide) is an organic compound that can be used as a plasticizer and an industrial solvent.
S2538 Acetanilide Acetanilide is an aniline derivative and has possess analgesic.
S4506 Acetazolamide Acetazolamide (Diamox), a potent carbonic anhydrase (CA) inhibitor, is commonly used in clinical practice as an immediate and readily available option for acute reduction of intraocular pressure(IOP).
S2999 Acetic acid octyl ester

Acetic acid octyl ester (Octyl acetate) is one of the major components of essential oils in the vittae, or oil tubes, of the wild parsnip (Pastinaca sativa). Acetic acid octyl ester exhibits antioxidant activity.

S5717 Acetohexamide Acetohexamide is an intermediate-acting, first-generation oral sulfonylurea with hypoglycemic activity. It exerts the blood-glucose-lowering effects by stimulating the pancreatic beta cells to secrete insulin and by helping the body use insulin efficiently.
S4602 Acetohydroxamic acid Acetohydroxamic acid (N-Hydroxyacetamide, Methylhydroxamic acid, Acetic acid|oxime, Lithostat) is an Urease Inhibitor. In the urine, it acts as an antagonist of the bacterial enzyme urease.
S6117 Acetoin dimer Acetoin is an important physiological metabolite excreted by many microorganisms. It is widely used in food and cosmetic industry as taste and fragrance enhancer.
S5528 Acetophenone Acetophenone (Methyl phenyl ketone, Phenylethanone) is an organic compound used as fragrances and a raw material for the synthesis of some pharmaceuticals.
S4955 Acetosyringone Acetosyringone (Acetosyringenin) is a phenolic natural product with analgesic, antipyretic and anti-inflammatory actions.
S3934 Acetyl Resveratrol Acetyl Resveratrol is the derivative compound of resveratrol, which is a potent phenolic antioxidant found in grapes and red wine.
S1805 Acetylcholine Chloride The chemical compound Acetylcholine Chloride is a neurotransmitter in both the peripheral nervous system (PNS) and central nervous system (CNS) in many organisms including humans.
S4718 Acetylcholine iodide Acetylcholine iodide (Acetylcolina) is a neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.
S3269 Acetylcorynoline Acetylcorynoline, a major alkaloid component derived from Corydalis bungeana which is a traditional Chinese medical herb, shows anti-inflammatory properties. Acetylcorynoline may decrease egl-1 expression to suppress apoptosis pathways and increase rpn5 expression to enhance the activity of proteasomes.
S1623 Acetylcysteine (N-acetylcysteine) Acetylcysteine (N-acetyl-l-cysteine, NAC) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor. Acetylcysteine(N-acetyl-l-cysteine) suppresses TNF-induced NF-κB activation through inhibition of IκB kinases. Acetylcysteine(N-acetyl-l-cysteine) induces apoptosis via the mitochondria-dependent pathway. Acetylcysteine(N-acetyl-l-cysteine) inhibits ferroptosis and virus replication.Solutions of Acetylcysteine are best fresh-prepared.
S5201 Acetylisovaleryltylosin Tartrate Acetylisovaleryltylosin tartrate (AK105039) is an antimicrobial of the macrolide group with antibacterial activity against Gram-positive bacteria.
S4514 Acetylleucine Acetylleucine (N-acetyl-L-leucine) is a drug used in the treatment of vertigo.
S3618 Acetylspiramycin (ASPM) Acetylspiramycin (ASPM, Spiramycin II, Foromacidin B) is a macrolide antimicrobial agent.
S3976 Acetylvanillin Acetylvanillin (Acetovanillin, Vanillin acetate, 4-Acetoxy-3-methoxybenzaldehyde, 4-Formyl-2-methoxyphenyl acetate), is found in pulses and is a flavouring material.
E0317 ACH-000143

ACH-000143 is a potent melatonin receptor agonist, with EC50 values of 0.06 nM and 0.32 nM for MT1 and MT2, respectively.

S1807 Aciclovir (BW 248U) Acyclovir (BW 248U, Acyclovir, Acycloguanosine, Zovirax, ACV, NSC 645011) is a synthetic nucleoside analogue active against herpesviruses. Acyclovir induces cell cycle perturbation and apoptosis in Jurkat leukemia cells.
S6158 Acid orange 7 Acid orange 7 (2-naphthol orange, Orange II, CI 15510, D&C Orange 4, COLIPA C015) is an azo dye used for dyeing wool.
S6152 Acid Red 27 Acid Red 27 (Azorubin S, Amaranth) is a modified red azo dye used as a food dye and to color cosmetics.
S6064 Acid Yellow 23 Acid Yellow 23 is a popular colorant for multiple applications, commonly used in ink, pond dyes, and textiles.
S6189 Acid Yellow 36 Acid Yellow 36 (Metanil Yellow) is a dye of the azo class and used as a pH indicator and it has a color change from red to yellow between pH 1.2 and 2.3.
S1806 Acipimox Acipimox (Olbemox) is a niacin derivative used as a hypolipidemic agent.
S1368 Acitretin Acitretin (Etretin, RO 10-1670) is a second generation retinoid used for psoriasis.
S4031 Aclidinium Bromide Aclidinium Bromide (LAS 34273, LAS-W 330) inhibits human muscarinic AChR M1, M2, M3, M4 and M5 with Ki of 0.1 nM, 0.14 nM, 0.14 nM, 0.21 nM and 0.16 nM, respectively.
S5075 Acotiamide Acotiamide (Acofide, Z388) is a novel acetylcholinesterase inhibitor with fundus-relaxing and gastroprokinetic properties.
S4838 Acotiamide hydrochloride Acotiamide Hydrochloride (YM-443, Z-338) is the hydrochloride salt form of acotiamide, a prokinetic agent with gastrointestinal (GI) motility-enhancing activity. It is a new orally active selective acetylcholinesterase inhibitor.
S0839 ACP-105 ACP-105 is an orally available and potent selective androgen receptor modulator (SARM) with pEC50 of 9.0 and 9.4 for AR wild type and AR mutation T877A, respectively.
S5718 Acrivastine Acrivastine is an antihistamine medicine that relieves the symptoms of allergies.
S6227 Acrylamide monomer Acrylamide is a neurotoxic monomer with extensive industrial applications. It could be used as a precursor to polyacrylamides.
S8588 ACSS2 inhibitor ACSS2 inhibitor is the most potent and specific inhibitor of acetate-dependent acetyl-CoA synthetase 2 (ACSS2). ACSS2 inhibitor also inhibits the respiratory syncytial virus (RSV).
S0556 ACT-389949 ACT-389949 is a potent, selective agonist of formyl peptide receptor type 2 (FPR2)/Lipoxin A4 receptor (ALX) with EC50 of 3 nM for FPR2/ALX internalization into monocytes. ACT-389949 has potential for inflammatory disorders.
S6382 ACT-678689 ACT-678689 (Compound Example 1.53.4) is an inhibitor of tryptophan hydroxylase (TPH) with IC50 of 8 nM.
S5039 Actarit Actarit (4-acetylaminophenylacetic acid) is an orally active immunomodulator used in the treatment of rheumatoid arthritis.
A5397 ACVRL1 Rabbit Recombinant mAb ACVRL1 Rabbit Recombinant mAb detects endogenous level of total ACVRL1.
S8648 ACY-738 ACY-738 inhibits HDAC6 with low nanomolar potency (IC50=1.7 nM) and a selectivity of 60- to 1500-fold over class I HDACs.
S0864 ACY-775 ACY-775 is a potent and selective histone deacetylase 6 (HDAC6) inhibitor with IC50 of 7.5  nM.
S8518 AD80 AD80, a multikinase inhibitor, shows strong activity against human RET (c-RET), BRAF, S6K, and SRC but were much less active than either AD57 or AD58 against mTOR. The IC50 value for RET is 4 nM.
S8884 Adagrasib (MRTX849) Adagrasib (MRTX849) is a potent, selective, and covalent KRASG12C inhibitor that exhibits favorable drug-like properties, selectively modifies mutant cysteine 12 in GDP-bound KRASG12C and inhibits KRAS-dependent signaling.
A2010 Adalimumab (anti-TNF-alpha) Adalimumab (anti-TNF-alpha) is the first fully human, recombinant IgG1 monoclonal antibody that specifically targets human TNF-alpha, MW: 144.19 KD.
A5298 ADAM10 Rabbit Recombinant mAb ADAM10 Rabbit Recombinant mAb detects endogenous level of total ADAM10.
S2869 Adamantane

Adamantane is a colorless, crystalline chemical compound first isolated from petroleum with a camphor-like odor. Adamantane is used to treat influenza A virus infections.

S1276 Adapalene Adapalene (CD-271) is a dual RAR and RXR agonist, used in the treatment of acne.
S8501 Adaptavir (DAPTA) Adaptavir (DAPTA, D-Ala-peptide T-amide, peptide T) is a water soluble potent, selective CCR5 antagonist which potently inhibits specific CD4-dependent binding of gp120 Bal (IC50 = 0.06 nM) and CM235 (IC50 = 0.32 nM) to CCR5.
E0466 Adarotene

Adarotene (ST1926) is a synthetic, phenolic hydroxyl retinoid with proapoptotic activity.

S8761 Adavivint (SM04690) Adavivint (SM04690) is a potent and specific inhibitor of canonical Wnt signaling with an EC50 of 19.5 nM for inhibiting the TCF/LEF reporter. It is ∼150- to 500-fold more potent than the other known Wnt inhibitors across multiple cellular assays.
S1525 Adavosertib (MK-1775) Adavosertib (MK-1775, AZD1775) is a potent and selective Wee1 inhibitor with IC50 of 5.2 nM in a cell-free assay; hinders G2 DNA damage checkpoint. Phase 2.
S5068 Adefovir Adefovir is an orally administered nucleotide analog reverse transcriptase inhibitor used for treatment of hepatitis B and herpes simplex virus infection.
S1718 Adefovir Dipivoxil (GS 0840) Adefovir Dipivoxil (GS 0840) is a reverse transcriptase inhibitor, used in the treatment of chronic hepatitis B virus (HBV).
S6551 Adelmidrol Adelmidrol is an analogue of palmitoylethanolamide (PEA) with anti-inflammatory activities.
S5109 Ademetionine Ademetionine (AdoMet, S-Adenosylmethionine, SAMe), also known as SAMe, is a specific form of the amino acid methionine known as S-adenosyl-methionine. It is essential for the formation of glutathione, a water-soluble peptide that helps the body fight free radicals.
S4515 Ademetionine disulfate tosylate Ademetionine Disulfate Tosylate is the disulfate-tosylate mixed salt of a mixture of diastereoisomers of the ademetionine ions. Ademetionine possesses anti-inflammatory activity and has been used in treatment of chronic liver disease.
S1981 Adenine Adenine is a purine derivative and a nucleobase with a variety of roles in biochemistry.
S1983 Adenine HCl Adenine HCl is a hydrochloride salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry.
S1982 Adenine sulfate Adenine sulfate is a sulfate salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry.
S1647 Adenosine Adenosine is a nucleoside composed of a molecule of adenine attached to a ribose sugar molecule (ribofuranose) moiety via a β-N9-glycosidic bond.
S5284 Adenosine 5'-monophosphate monohydrate Adenosine 5'-monophosphate monohydrate (5'-Adenylic acid, 5'-AMP) is an activator of a class of protein kinases known as AMP-activated protein kinase (AMPK).
S6325 Adenosine 5′-diphosphate sodium salt Adenosine 5′-diphosphate (ADP, Adenosine diphosphate, Adenosine 5′-pyrophosphate, Adenosine pyrophosphate) is an important organic compound in metabolism and is essential to the flow of energy in living cells. ADP can be interconverted to adenosine triphosphate (ATP) and adenosine monophosphate (AMP).
S9370 Adenosine Cyclophosphate Adenosine Cyclophosphate (Cyclic adenosine monophosphate, cAMP, cyclic AMP, 3',5'-cyclic adenosine monophosphate) is useful for improving myocardial hypoxia, dilating coronary artery and strengthening myocardiac contraction.
S8608 Adenosine Dialdehyde (ADOX) Adenosine Dialdehyde (ADOX) is an adenosine analog and S-adenosylmethionine-dependent methyltransferase inhibitor with an IC50 of 40 nM.
S9367 Adenosine disodium triphosphate Adenosine disodium triphosphate (ATP disodium) is the sodium salt form of adenosine triphosphate (ATP), a complex organic chemical that provides energy to drive many processes in living cells.
S1076 Adezmapimod (SB203580) Adezmapimod (SB203580, RWJ 64809, PB 203580) is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM in THP-1 cells, 10-fold less sensitive to SAPK3(106T) and SAPK4(106T) and blocks PKB phosphorylation with IC50 of 3-5 μM. SB203580 induces mitophagy and autophagy.
S0525 ADH-503 (GB1275) ADH-503 (GB1275, (Z)-Leukadherin-1 choline) is the salt form of leukadherin-1 and acts as a potent allosteric agonist of CD11b.
S0232 Adipamidoxime (NSC 70868) Adipamidoxime (NSC 70868) is a new bioactive compoud.
S2082 Adiphenine HCl Adiphenine HCl is a nicotinic receptor inhibitor, used as an antispasmodic drug.
S3594 Adipic acid Adipic acid (Hexanedioic acid) is an important dicarboxylic acid used for the manufacture of nylon and polyurethane plastics.
S7365 AdipoRon AdipoRon (SC-396658) is a novel, and orally bioavailable adiponectin receptor agonist with KD of 1.8 and 3.1 μM for AdipoR1 and AdipoR2, respectively.
S0454 Adjudin Adjudin (AF-2364), a potent male contraceptive, is a potent blocker of Cl⁻ channels. Adjudin exhibits anti-inflammatory properties by suppression of NF-κB p65 nuclear translocation and DNA binding activity as well as ERK MAPK phosphorylation.
S1139 ADL5859 HCl ADL5859 HCl is a δ-opioid receptor agonist with Ki of 0.8 nM, selectivity against opioid receptor κ, μ, and weak inhibitory activity at the hERG channel. Phase 2.
S0555 Adomeglivant Adomeglivant (LY2409021) is a potent and selective antagonist of glucagon receptor that is used as a chronic treatment for type 2 diabetes.
A5415 ADORA1 Rabbit Recombinant mAb ADORA1 Rabbit Recombinant mAb detects endogenous level of total ADORA1.
S9368 ADP ADP (Adenosine diphosphate, adenosine pyrophosphate, Adenosine 5'-diphosphate) is an important organic compound in metabolism and is essential to the flow of energy in living cells.
S5224 Adrafinil Adrafinil (benzhydrylsulfinylacetohydroxamic acid, adrafinyl, CRL-40028) is a mild central nervous system stimulant drug directly affecting CNS function. It is used to relieve excessive sleepiness and inattention in elderly patients.
S3185 Adrenalone HCl Adrenalone is an adrenergic agonist used as a topical vasoconstrictor and hemostatic, mainly acts on alpha-1 adrenergic receptors.
S4773 Adrenosterone Adrenosterone (Reichstein's substance G, 11-ketoandrostenedione, 11-oxoandrostenedione) is endogenous steroid hormone that has been promoted as a dietary supplement capable of reducing body fat and increasing muscle mass.
S3192 ADX-102

ADX-102 (NS-2) is a free aldehyde trapper potentially useful in the treatment of inflammation, uveitis, and fatty aldehyde dehydrogenase deficiency.

S2690 ADX-47273 ADX47273 (BA 94673139) is a potent and specific mGlu5 positive allosteric modulator(PAM) with EC50 of 0.17 μM, showing no activity at other mGlu subtypes.
S0246 ADX-88178 ADX88178 is a potent positive allosteric modulator (PAM) of metabotropic glutamate receptor 4 (mGluR4) with EC50 of 4 nM for human mGluR4.
S1486 AEE788 (NVP-AEE788) AEE788 (NVP-AEE788) is a potent inhibitor of EGFR and HER2/ErbB2 with IC50 of 2 nM and 6 nM, less potent to VEGFR2/KDR, c-Abl, c-Src, and Flt-1, does not inhibit Ins-R, IGF-1R, PKCα and CDK1. Phase 1/2.
S3454 AEM1 AEM1 is an inhibitor of deregulated NRF2 transcriptional activity in cancer.
E0343 AES-350

AES-350 is a potent and orally active HDAC6 inhibitor with an IC50 and a Ki of 0.0244 μM and 0.035 μM, respectively. AES-350 triggers apoptosis in AML cells through HDAC inhibition.

S0405 AF-353 AF-353 (Ro-4) is a potent, selective and orally bioavailable antagonist of P2X3 receptor and P2X2/3 receptor with pIC50 of 8.06, 8.05 and 7.41 for human P2X3, rat P2X3 and human P2X2/3, respectively.
S0173 AF64394 AF64394 is a selective GPR3 inverse agonist with pIC50 of 7.3.
S5303 Afalanine (N-Acetyl-DL-phenylalanine) Afalanine (N-Acetyl-DL-phenylalanine, Afalanine) acts as an antidepressant and a metabolite.
S1011 Afatinib (BIBW2992) Afatinib (BIBW2992) inhibits EGFR/ErbB irreversibly in vitro with IC50 of 0.5, 0.4, 10, 14, 1 nM for EGFRwt, EGFR L858R , EGFR L858R/T790M ErbB2 (HER2) and ErbB4 (HER4), respectively. Afatinib induces autophagy.
S7810 Afatinib (BIBW2992) Dimaleate Afatinib (BIBW2992) Dimaleate irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively; 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant. Afatinib (BIBW2992) Dimaleate induces autophagy.
E1016 Aficamten (CK-274)

Aficamten (CK-274, CK 3773274) is a novel cardiac myosin inhibitor that reduces myocardial contractility in vitro and in vivo with an IC50 of 1.4 μM.

S3663 Afloqualone Afloqualone (AFQ, HQ-495) is a quinazolinone family GABAergic drug with muscle-relaxant and sedative effects, showing the agonist activity at the β subtype of the GABAa receptor.
S0304 Aftin-4 Aftin-4 is an Amyloid-β42 (Aβ42) inducer.
S7521 Afuresertib (GSK2110183) Afuresertib (GSK2110183) is a potent, orally bioavailable Akt inhibitor with Ki of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. Phase 2.
S0245 AG 1406 AG 1406 is a potent and selective receptor tyrosine kinase VEGF receptor 2 inhibitor.
S6509 AG 494 AG-494, a member of the tyrphostin family of tyrosine kinase inhibitors, is a potent inhibitor of EGF receptor autophosphorylation (IC50=1.2 μM) and EGF-dependent cell growth (IC50=6 μM).
S6525 AG 555 AG-555 (Tyrphostin B46) is an inhibitor of tyrosine kinase, interacts directly with topoisomerase I, thus preventing DNA relaxation. It inhibits EGFR with an IC50 of 0.7 μM.
S0736 AG 556 AG 556 is an inhibitor of EGFR kinase autophosphorylation over HER1/2 autophosphorylation.
S1234 AG-1024 AG-1024 (Tyrphostin, AGS 200) inhibits IGF-1R autophosphorylation with IC50 of 7 μM, is less potent to IR with IC50 of 57 μM and specifically distinguishes between InsR and IGF-1R (as compared to other tyrphostins).
S0718 AG-120 (racemic) AG-120 (racemic), the racemic mixture of AG-120, is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1) with potential antineoplastic activity.
S6596 AG-126 AG126 is a tyrosine kinase inhibitor which selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 μM.
S2211 AG-13958 AG-13958 (AG-013958), a VEGFR tyrosine kinase inhibitor, is in clinical development with ST administration for treatment of choroidal neovascularization associated with age–related macular degeneration (AMD).
S2178 AG-14361 AG14361 is a potent inhibitor of PARP1 with Ki of <5 nM in a cell-free assay. It is at least 1000-fold more potent than the benzamides.
S2728 AG-1478 (Tyrphostin AG-1478) AG-1478 (Tyrphostin AG-1478, NSC 693255) is a selective EGFR inhibitor with IC50 of 3 nM in cell-free assays, almost no activity on HER2-Neu, PDGFR, Trk, Bcr-Abl and InsR. AG-1478 (Tyrphostin AG-1478) inhibits encephalomyocarditis virus (EMCV) and hepatitis c virus (HCV) by targeting phosphatidylinositol 4-kinase IIIα (PI4KA).
S0151 AG-1557 AG-1557 is a specific and ATP competitive inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase.
S8009 AG-18 AG-18 (RG-50810, Tyrphostin A23, TX 825) inhibits EGFR with IC50 of 35 μM.
S1143 AG-490 (Tyrphostin B42) AG-490 (Tyrphostin B42, Zinc02557947) is an inhibitor of EGFR with IC50 of 0.1 μM in cell-free assays, 135-fold more selective for EGFR versus ErbB2, also inhibits JAK2 with no activity to Lck, Lyn, Btk, Syk and Src.
S9776 AG-636 AG-636 is an orally available inhibitor of dihydroorotate dehydrogenase (DHODH) with potential antineoplastic activity.
S0760 AG473 AG473 is a bioactive compound.
S1054 AG99 AG99 (Tyrphostin 46,Tyrphostin A46,Tyrphostin B40) is a potent and selective inhibitor of EGFR.
S3263 Agarotetrol Agarotetrol is a chromone derivative found in high concentrations in the water-extract fraction of agarwood. Agarotetrol contributes to the fragrance of agarwood through the generation of LACs upon heating.
S8015 Agerafenib (RXDX-105) Agerafenib (RXDX-105, CEP-32496) is a highly potent inhibitor of BRAF(V600E/WT) and c-Raf with Kd of 14 nM/36 nM and 39 nM, also potent to Abl-1, c-Kit, Ret (c-Ret), PDGFRβ and VEGFR2, respectively; insignificant affinity for MEK-1, MEK-2, ERK-1 and ERK-2. Phase 1/2.
S6420 AGI 1067 AGI-1067 is a novel, phenolic, intra- and extracellular antioxidant that inhibits the expression of a number of proinflammatory genes involved in atherosclerosis.
S7185 AGI-5198 AGI-5198 (IDH-C35) is the first highly potent and selective inhibitor of IDH1 R132H/R132C mutants with IC50 of 0.07 μM/0.16 μM.
S7577 AGK2 AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels.
S4962 Agmatine sulfate Agmatine sulfate is a bioactive metabolite of the arginine amino acid. It has been shown to increase nitric oxide, reduce blood sugar levels and even increase growth hormone levels.
S1243 Agomelatine (S20098) Agomelatine (S20098) is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor.
S9477 AH7614 AH7614 (compound 39) is a selective FFA4 (GPR120) antagonist with pIC50s of 7.1 for human FFA4 and 8.1 for mouse FFA4.
A5463 AhR Rabbit Recombinant mAb AhR Rabbit Recombinant mAb detects endogenous level of total AhR.
S6026 AI-10-47 AI-10-47 is an inhibitor of CBFβ-RUNX binding with IC50 of 3.2 μM.
S1802 AICAR (Acadesine) AICAR (Acadesine, NSC105823, AICA Riboside), an AMPK activator, results in accumulation of ZMP, which mimics the stimulating effect of AMP on AMPK and AMPK kinase. AICAR (Acadesine) induces mitophagy. Phase 3.
S6885 Ailanthone Ailanthone (AIL, Δ13-Dehydrochaparrinone), a natural anti-hepatocellular carcinoma (HCC) component in Ailanthus altissima, induces G0/G1-phase cell cycle arrest by decreasing expression of cyclins and CDKs and increases expression of p21 and p27. Ailanthone triggers DNA damage characterized by activation of the ATM/ATR pathway. Ailanthone induces apoptosis which is mitochondrion-mediated and involves the PI3K/AKT signaling pathway in Huh7 cells. Ailanthone is also a potent inhibitor of both full-length Androgen Receptor (AR-FL) and constitutively active truncated AR splice variants (AR-Vs, AR1-651) with IC50 of 69 nM and 309 nM, respectively.
S2212 AIM-100 AIM-100 is a potent small molecule inhibitor of Ack1 with IC50 of 24nM.
S5371 Ajmaline Ajmaline (Cardiorythmine, Tachmalin), found in the root of Rauwolfia serpentina, is a class Ia antiarrhythmic agent.
S5455 Akebia saponin D Akebia saponin D (Asperosaponin VI), the most abundant constituent of the rhizome of Dipsacus asper, has been used for the treatment of lower back pain, traumatic hematoma and bone fractures.
E0338 AKI603

AKI603 is an inhibitor of Aurora kinase A (AurA) with an IC50 of 12.3 nM. AKI603 exhibits strong anti-proliferative activity in leukemic cells.

S5557 Aklomide Aklomide (2-Chloro-4-nitrobenzamide) is a coccidiostat and used to fight disease, parasites and insects that infest poultry.
S6801 AKOS B018304 AKOS B018304, an arylalkylidene derivative with polar substitution at para-position, is a potent inhibitor of chikungunya virus with low micro molar activity.
S0764 AKR1C1-IN-1 AKR1C1-IN-1 is a potent and selective inhibitor of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) with Ki of 4 nM, 87 nM, 4.2 μM and 18.2 μM for AKR1C1, AKR1C2, AKR1C3 and AKR1C4, respectively.
A5031 AKT1/2/3 Rabbit Recombinant mAb

AKT1/2/3 Rabbit Recombinant mAb detects endogenous levels of AKT1/2/3.

S7776 Akti-1/2 Akti-1/2 (Akt Inhibitor VIII) is a highly selective Akt1/Akt2 inhibitor with IC50 of 58 nM/210 nM, respectively, about 36-fold selectivity for Akt1 over Akt3. Akti-1/2 induces apoptosis.
S6608 AL082D06 AL082D06 is a nonsteroidal glucocorticoid receptor (GR) antagonist with no detectable binding affinity for the highly related receptors for mineralocorticoids, androgens, estrogens, and progestins.
S5801 Ala-Gln Ala-Gln (l-alanyl-l-glutamine), a dipeptide composed of alanine and Gln, is an alternative supplement to L-glutamine in the production of biopharmaceuticals with better solubility and stability than glutamine (Gln).
S8318 Alantolactone Alantolactone (helenin, helenine, Eupatal), a naturally occurring eudesmane-type sesquiterpene lactone (SL), could induce activin/SMAD3 signaling and disrupt Cripto-1/activin receptor type II A interaction.
A5239 Alas1 Rabbit Recombinant mAb Alas1 Rabbit Recombinant mAb detects endogenous level of total Alas1.
S1640 Albendazole (SKF-62979) Albendazole (SKF-62979) is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations.
S1836 Albendazole Oxide Albendazole Oxide (Ricobendazole) is a tubulin polymerization or assembly inhibitor, used for the treatment of a variety of parasitic worm infestations.
S3734 Albiglutide Fragment Albiglutide fragment is one copy of a 30-amino-acid sequence of modified human GLP-1 (fragment 7-36).
E0446 ALC-0159 ALC-0159 is a polyethylene glycol (PEG) lipid conjugate. ALC-0159 allows forming a hydrophilic layer that sterically stabilizes the nanosystem, contributing to storage stability and reducing non-specific binding to proteins.
E0139 ALC-0315

ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization.

S4625 Alcaftadine Alcaftadine (Lastacaft, R89674) is a high affinity ligand for the H1 receptor, with a pKi (8.5) that is comparable with that of other H1 antihistamines. Alcaftadine is also an antagonist for H2 and H4 receptors with no affinity for the H3 receptor.
S0633 Ald-Ph-amido-PEG4-C2-acid Ald-Ph-amido-PEG4-C2-acid is a non-cleavable linker used for the antibody-drug conjugates (ADCs).
S0629 Ald-Ph-amido-PEG4-C2-NHS ester Ald-Ph-amido-PEG4-C2-NHS ester is a non-cleavable 4-unit PEG linker for antibody-drug-conjugation (ADC).
S0602 Ald-Ph-NHS ester Ald-Ph-NHS ester is an uncleavable linker for antibody-drug-conjugation (ADC).
A5171 ALDH1A1 Rabbit Recombinant mAb ALDH1A1 Rabbit Recombinant mAb detects endogenous level of total ALDH1A1.
S2762 Alectinib (CH5424802) Alectinib (CH5424802, AF-802, RG-7853) is a potent ALK inhibitor with IC50 of 1.9 nM in cell-free assays, sensitive to L1196M mutation and higher selectivity for ALK than PF-02341066, NVP-TAE684 and PHA-E429.
S5232 Alectinib (CH5424802) hydrochloride Alectinib (AF802, CH5424802, RO5424802, RG-7853) is a second generation oral drug that selectively inhibits the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase.
S1624 Alendronate sodium trihydrate Alendronate sodium trihydrate (G-704650, MK-217), a nitrogen-containing bisphosphonate, is a potent inhibitor of bone resorption used for the treatment and prevention of osteoporosis.
S5536 Alendronic Acid Alendronic acid (alendronate) is a nitrogen-containing, second generation bisphosphonate used for osteoporosis, osteogenesis imperfecta, and several other bone diseases.
S5126 Aleuritic Acid Aleuritic Acid (Aleuritolic acid, 9,10,16-trihydroxy-palmitic acid), a major constituent acid of lac resin (shellac), is isolated from the resin and mainly used in the perfumery industry as a starting material for the preparation of "musk" aroma compounds as well as medicinal and bioactive compounds.
S1468 Alfacalcidol Alfacalcidol (1-hydroxycholecalciferol) is a non-selective VDR activator medication.
S6868 Alflutinib (AST2818) mesylate Alflutinib (AST2818, Furmonertinib) mesylate is a third-generation epidermal growth factor receptor (EGFR) inhibitor that inhibits both EGFR-sensitive mutations and T790M mutations. Alflutinib (AST2818), primarily metabolized by CYP3A4, is also a potent CYP3A4 inducer with EC50 of 0.25 μM.
S5766 Alfuzosin Alfuzosin, a quinazoline derivative, is a selective and competitive α1-adrenoceptor antagonist.
S1409 Alfuzosin HCl Alfuzosin HCl is an alpha1 receptor antagonist used to treat benign prostatic hyperplasia (BPH).
S1928 Alibendol Alibendol (EB 1856) is an antispasmodic,choleretic, and cholekinetic.
S5730 Alimemazine Tartrate Alimemazine (Trimeprazine Tartrate, Methylpromazine Tartrate) is a phenothiazine derivative that is used as an antipruritic.
S1133 Alisertib (MLN8237) Alisertib (MLN8237) is a selective Aurora A inhibitor with IC50 of 1.2 nM in a cell-free assay. It has >200-fold higher selectivity for Aurora A than Aurora B. Alisertib induces cell cycle arrest, apoptosis and autophagy. Phase 3.
S5767 Aliskiren Aliskiren is a renin inhibitor with antihypertensive activity.
S2199 Aliskiren Hemifumarate Aliskiren hemifumarate is a direct renin inhibitor with IC50 of 1.5 nM.
S0959 Alismoxide Alismoxide is a natural product with anti-inflammatory effects.
S9276 Alisol B Alisol B, a triterpene from Alismatis rhizoma, induces Bax up-regulation and nuclear translocation, the activation of initiator caspase-8 and caspase-9, and executor caspase-3, suggesting the involvement of both extrinsic and intrinsic apoptosis pathways.
A5508 ALIX Rabbit Recombinant mAb ALIX Rabbit Recombinant mAb detects endogenous level of total ALIX.
S4257 Alizapride HCl Alizapride HCl is a dopamine receptor antagonist used for the theropy of nausea and vomiting.
S2526 Alizarin Alizarin (Anthraquinonic) strongly inhibits P450 isoform CYP1A1, CYP1A2 and CYP1B1 with IC50 of 6.2 μM, 10.0 μM and 2.7 μM, respectively; weakly inhibits CYP2A6 and CYP2E1, and does not inhibit CYP2C19, CYP3A4 and CYP3A5.
S5974 Alizarin Red S Alizarin Red S sodium (Alizarin red S mono sodiumsalt, ARS sodium, C.I. Mordant Red 3, C.I 58005, Alizarin Carmine, Alizarin Red, Alizarin sodium monosulfonate, Alizarin sulfonate sodium, Alizarinsulfonic acid sodium salt, Sodium alizarinsulfonate) is an anthraquinone dye that has been used to evaluate calcium-rich deposits by cells in culture.
S0543 ALK inhibitor 2 ALK inhibitor 2 is a novel and selective ALK kinase inhibitor.
S0887 ALK2-IN-1 ALK2-IN-1 (BLU-782) is a potent and selective inhibitor of Activin receptor-like kinase (ALK2) mutant R206H with binding IC50 of <10 nM.
A5111 Alkaline Phosphatase Rabbit Recombinant mAb Alkaline Phosphatase Rabbit Recombinant mAb detects endogenous levels of total alkaline phosphatase.
L7900 Alkaloid Compound Library A unique collection of 413 alkaloid compounds used for high throughput screening(HTS) and high content screening(HCS).
E0471 Alkyne tyramide

Alkyne tyramide is a clickable ascorbate peroxidase 2 (APEX2) probe. Alkyne tyramide improves APEX-labeling efficiency in intact yeast cells, as it is more cell wall-permeant than APEX2 substrate biotin-phenol (BP).

S6132 All trans-Retinal All trans-Retinal (Retinaldehyde, Vitamin A aldehyde, Retinene), a component of the retinoid cycle, is converted to retinoic acid in vivo by the action of retinal dehydrogenase. Retinoic acid is a ligand for both RAR and RXR. All trans-retinal ias a potent photosensitizer.
S3856 Allantoin Allantoin (Glyoxyldiureide, 5-Ureidohydantoin), produced from uric acid, is a major metabolic intermediate in most organisms including animals, plants and bacteria.
S3860 Allicin Allicin (Diallyl Thiosulfinate), the main biologically active component of the freshly crushed garlic extracts, possesses various biological activities including antibacterial, antifungal and antiparasitic effects.
S9397 Alliin Alliin (S-allyl cysteine sulfoxide, ACSO, 3-(Allylsulphinyl)-L-alanine) is a sulfoxide that is a natural constituent of fresh garlic.
S2185 Allitinib (AST-1306) Allitinib (AST-1306, AST-6) is a novel irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM, also effective in mutation EGFR T790M/L858R, more potent to ErbB2-overexpressing cells, 3000-fold selective for ErbB family than other kinases.
S9347 Allitol Allitol (Allodulcitol) is a rare polyol found in nature that is useful not only as a sweetener, but also as the raw material for production of chemical compounds.
S0948 Allocryptopine Allocryptopine potently blocks hERG (human ether-a-go-go related gene) current with antiarrhythmic effects. Allocryptopine is a derivative of tetrahydropalmatine extracted from Corydalis decumbens (Thunb.) Pers. Papaveraceae.
S5805 Allopregnanolone Allopregnanolone, a neurosteroid synthesized from progesterone in brain, acts as a highly potent positive allosteric modulator of the GABAA receptor.
S1630 Allopurinol Allopurinol is a purine analog inhibitor of the enzyme xanthine oxidase, used to treat gout or kidney stones, and to decrease levels of uric acid.
S1631 Allopurinol Sodium Allopurinol Sodium is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM.
S0917 Allosecurinin Allosecurinine (Phyllochrysine) is a Securinega alkaloid isolated from M.indica and M.discoidea with antifungal activity.
E0196 Alloxan Monohydrate

Alloxan Monohydrate is the most popular diabetogenic agents used for assessing the antidiabetic or hypoglycemic capacity of test compounds.

S5427 Alloxazine Alloxazine (Isoalloxazine) is an A2 receptor antagonist, which is approximately 10-fold more selective for the A2B receptor than for the A2A receptor.
S6204 Allyl Methyl Sulfide Allyl Methyl Sulfide (3-Methylthio-1-propene), a bioactive organosulfur compound found in garlic, is reported to modulate disease states such as cancer and infection.
S5219 Allylestrenol Allylestrenol is an orally active progestagen of the 19-nortestosterone series resembling progesterone.
S4017 Allylthiourea Allylthiourea is a metabolic inhibitor that selective inhibits ammonia oxidation.
S4439 Almitrine mesylate Almitrine mesylate (Almitrine bismesylate, Almitrine dimethanesulfonate, Almitrine dimesylate), a pharmacologically unique respiratory stimulant, acts as an agonist of peripheral chemoreceptors located on the carotid bodies. Almitrine mesylate inhibits the activity of Ca2+-dependent K+ channel by decreasing its open probability with IC50 of 0.22 μM.
S8817 Almonertinib (HS-10296) Almonertinib (Aumolertinib, HS-10296, Ameile) is a small molecule inhibitor of EGFR-activating mutations and T790M-resistant mutation with limited activity against wild-type EGFR.
S2160 Almorexant HCl Almorexant HCl (ACT-078573) is an orally active, dual orexin receptor antagonist with IC50 of 6.6 nM and 3.4 nM for OX1 and OX2 receptor, respectively. Phase 3.
S2096 Almotriptan Malate Almotriptan Malate (LAS 31416) is a selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor agonist, used for the treatment of Migraine attacks in adults.
S8961 Alobresib (GS-5829) Alobresib (GS-5829) is a novel BET inhibitor that represents a highly effective therapeutics agent against recurrent/chemotherapy-resistant USC-overexpressing c-Myc. Alobresib (GS-5829) inhibits CLL cell proliferation and induces leukemia cell apoptosis through deregulation of key signaling pathways, such as BLK, AKT, ERK1/2, and MYC. Alobresib (GS-5829) also inhibits NF-κB signaling.
S0652 Aloc-D-Ala-Phe-Lys(Aloc)-PAB-PNP Aloc-D-Ala-Phe-Lys(Aloc)-PAB-PNP is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S2259 Aloe-emodin Aloe-emodin (NSC 38628, Rhabarberone) is an interferon-inducing agent with IC50 of about 1 μg/mL for JEV and of about 0.33 μg/mL for EV71.
S9284 Aloesin Aloesin (Aloe resin B) is a kind of herbal extraction form the aloe vera. It is a strong inhibitor of tyrosinase activity and up-regulates cyclin E-dependent kinase activity in vitro.
S8754 Alofanib (RPT835) Alofanib (RPT835) is a novel selective allosteric inhibitor of FGFR2 and has a dramatic inhibitory effect with IC50 <10 nM on FGF2-induced phoshphorylation of FRS2a in KATO III cells. It has no direct effect on FGF2-dependent FGFR1 and FGFR3 phosphorylation levels in either cell lines and no effects on FGF2-FGFR2 binding.
S5365 Alogliptin Alogliptin is a potent, selective inhibitor of the serine protease dipeptidyl peptidase IV (DPP-4) with IC50 values of 2.63 nM and exhibits greater than 10,000 fold selectivity over the closely related serine proteases DPP-8 and DPP-9.
S2868 Alogliptin (SYR-322) benzoate Alogliptin (SYR-322) benzoate is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9.
S2375 Aloin Aloin (Barbaloin, Barbalin), a natural anthracycline from Aloe vera, is a tyrosinase inhibitor.
S0936 Aloin B Aloin B (Isobarbaloin), one isomer of Aloin, is a physiologically active anthraquinone present in aloe.
S2420 Aloperine Aloperine is an isolated alkaloid in sophora plants such as Sophora alopecuroides L, and exhibits anti-inflammatory, antibacterial, antiviral, and anti-tumor properties.
S4694 Alosetron Hydrochloride Alosetron Hydrochloride (GR 68755C, GR 68755X, Lotronex) is the hydrochloride salt form of alosetron, a potent and selective 5-HT3 receptor antagonist.
S7393 Aloxistatin (E64d) Aloxistatin (E64d) is an irreversible and membrane-permeable cysteine protease inhibitor with blood platelet aggregation inhibiting activity. The cysteine protease cathepsin L is required for SARS-CoV-2 viral entry, and aloxistatin treatment reduced cellular entry of SARS-CoV-2 pseudovirions by 92.3%.
S2814 Alpelisib (BYL719) Alpelisib (BYL719) is a potent and selective PI3Kα inhibitor with IC50 of 5 nM in a cell-free assay, and minimal effect on PI3Kβ/γ/δ. Phase 2.
A5471 Alpha Actinin 4 Rabbit Recombinant mAb Alpha Actinin 4 Rabbit Recombinant mAb detects endogenous level of total Alpha Actinin 4.
S5112 alpha-Arbutin Alpha-arbutin (alpha-Arbutoside, 4-hydroxyphenyl-D-lucopyranoside) is a synthetic and functional active ingredient for skin lightening.
S4772 alpha-Asarone Alpha (α)-asarone (trans-Asarone) is one of the main pharmacologically active compounds present in Acorus calamus Linn (Acoraceae), Acorus tatarinowii Schott (Acoraceae), and Acorus gramineus Solander. It has anticonvulsant, neuroprotective, anxiolytic and nootropic effects.
S5910 Alpha-Estradiol Alpha-Estradiol (α-Estradiol, 17 alpha-Estradiol, Alfatradiol, Epiestradiol, Epiestrol, Alora, 17 α-E2), a natural, non-feminizing stereoisomer, a hormonally almost inactive isomer of physiological 17 beta-estradiol (17 β-E2), is a weak inhibitor of estrogen.
S3804 Alpha-Mangostin Alpha-mangostin is the main xanthone purified from mangosteen and has health promoting benefits including anti-bacterial, anti-inflammatory, anti-oxidant, anti-cancer and cardioprotective activities. alpha-Mangostin (α-Mangostin) is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM. Alpha-mangostin is also an agonist of human STING.
P1207 alpha-MSH TFA

alpha-MSH TFA (α-MSH TFA, α-MSH Trifluoroacetate, alpha-MSH Trifluoroacetate,α-Melanocyte-stimulating hormone TFA, α-Melanocyte-stimulating hormone Trifluoroacetate) is a 13-amino acid peptide hormone. an endogenous MC4R agonist. alpha-MSH TFA is an endogenous MC3R and MC4R agonist with EC50s of 0.16 nM and 56 nM for hMC3R and hMC4R in Hepa cells, respectively.

S5158 alpha-Naphthoflavone Alpha-Naphthoflavone (7,8-benzoflavone), a synthetic flavonoid, is a potent inhibitor of aromatase with an I50 value of 0.5 μM.
S3875 Alpinetin Alpinetin, a composition of Alpinia katsumadai Hayata, has been reported to have a number of biological properties, such as antibacterial, antitumor and other important therapeutic activities. Alpinetin is a flavonoid isolated from Alpinia katsumadai Hayata, activates activates PPAR-γ, with potent anti-inflammatory activity.
S5802 Alprenolol hydrochloride Alprenolol hydrochloride is the hydrochloride salt form of alprenolol, which is an beta adrenergic receptorantagonist and is used as an antihypertensive, anti-anginal, and anti-arrhythmic agent.
S1508 Alprostadil Alprostadil (Prostaglandin-E1, PGE1, Edex, Muse, Liprostin) is used as a drug in the treatment of erectile dysfunction and has vasodilatory properties. It is a Prostaglandin Analog and Prostaglandin E1 Agonist.
S5803 Alrestatin Alrestatin is an inhibitor of aldose reductase which is involved in the pathogenesis of complications of diabetes mellitus, including diabetic neuropathy.
S3197 ALS-22335

ALS22335 is an antiviral agent.

S0354 Alsterpaullone Alsterpaullone (Alp, 9-Nitropaullone, NSC 705701) is a potent inhibitor of CDK with IC50 of 35 nM, 15 nM, 200 nM and 40 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p35, respectively. Alsterpaullone also acts as a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with IC50 of both 4 nM for GSK-3α and GSK-3β. Alsterpaullone induces apoptosis by activation of caspase-9. Alsterpaullone has antitumor activity and possesses potential for the treatment of neurodegenerative and proliferative disorders.
S6412 Altiratinib Altiratinib (DCC-2701) is a potent single-digit nanomolar inhibitor of TRK, Met (c-Met), TIE2, and VEGFR2 kinases with IC50 vaules of 0.9 nM, 4.6 nM, and 0.8 nM for TRKA, B, and C, respectively. It inhibits Met (c-Met) and Met (c-Met) mutant with IC50 values in the range of 0.3-6 nM.
S3167 Altrenogest Altrenogest (A35957, RU2267) is a progestogen structurally related to veterinary steroid trenbolone.
S1278 Altretamine Altretamine (Hexamethylmelamine, NSC13875, ENT50852) is an anti-neoplastic agent.
S4826 Aluminium hydroxide Aluminium hydroxide (Aluminic), found in nature as the mineral gibbsite, is amphoteric (i.e., it has both basic and acidic properties). It is used to treat symptoms of increased stomach acid, such as heartburn, upset stomach, sour stomach, or acid indigestion; also reduce phosphate levels in people with certain kidney conditions.
S7218 Alvelestat (AZD9668) Alvelestat (AZD9668, Avelestat) is an oral, highly selective inhibitor of neutrophil elastase (NE) with IC50 and Ki of 12 nM and 9.4 nM, at least 600-fold more selective over other serine proteases. Phase 2.
S5945 Alverine Alverine is a smooth muscle relaxant.
S3054 Alverine Citrate Alverine citrate (NSC 35459) is a drug used for functional gastrointestinal disorders. Alverine citrate is a 5-HT1A receptor antagonist, with an IC50 of 101 nM.
S1142 Alvespimycin (17-DMAG) HCl Alvespimycin (17-DMAG, NSC 707545, BMS 826476, KOS 1022) HCl is a potent HSP90 inhibitor with IC50 of 62 nM in a cell-free assay. Phase 2.
S5935 Alvimopan Alvimopan (LY 246736, ADL 8-2698) is a potent, relatively nonselective opioid antagonist with Ki values of 0.77, 4.4, and 40 nM for the μ, δ, and κ opioid receptors, respectively, displaying >100-fold selectivity over other aminergic G-protein-coupled receptors.
S5701 Alvimopan dihydrate (LY246736 dihydrate) Alvimopan (LY-246736) is a potent, relatively nonselective opioid antagonist with Ki values of 0.77, 4.4, and 40 nM for the μ, δ, and κ opioid receptors, respectively, displaying >100-fold selectivity over other aminergic G-protein-coupled receptors.
S6515 ALW II-41-27 ALW II-41-27 (compound 7) is a potent inhibitor of Eph receptor tyrosine kinase with Kd of 12 nM for EphA2.
S6633 AM 095 AM095 is an antagonist of the LPA type 1 receptor with IC50 values of 0.98 and 0.73 μM for recombinant human and mouse LPA1, respectively.
S3527 AM-2394 AM-2394 is a structurally distinct glucokinase activator (GKA) with EC50 of 60 nM for glucokinase (GK).
S0134 AM-92016 Hydrochloride AM-92016 hydrochloride is a specific rectifier potassium current (IK) blocker. AM-92016 hydrochloride delays rectifier potassium channel (IK).
S1544 AM1241 AM-1241 is a selective cannabinoid CB2 receptor agonist with Ki of 3.4 nM, exhibits 82-fold selectivity over CB1 receptor.
S2819 AM251 AM251 block the inhibitory effects of endocannabinoids and synthetic cannabinoid agonists on transmitter release through an action at presynaptic cannabinoid 1 receptors in brain.
S2933 AM580 AM580 is a retinoic acid receptor agonist with Kd values of 8 nM, 131 nM and 450 nM for RARα, RARβ and RARγ.
S3534 AM966 AM966 is a potent, selective, and orally active antagonist of LPA(1) receptor that inhibits lung fibrosis in the mouse bleomycin model.
S5499 Amantadine Amantadine (1-Adamantanamine, 1-Adamantylamine, 1-Aminoadamantane) is an antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is an M2 inhibitor which blocks the ion channel formed by the M2 protein that spans the viral membrane.
S2451 Amantadine HCl Amantadine HCl (1-adamantanamine) is used to treat or prevent infections of the respiratory tract caused by a certain virus.
S1273 Amarogentin

Amarogentin (AG), a secoiridoid glycoside mainly extracted from Swertia and Gentiana roots, exhibits anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin is an agonist for the bitter taste receptor TAS2R1 and inhibits in LAD-2 cells substance P-induced production of newly synthesized TNF-α. Amarogentin induces apoptosis in human gastric cancer cells (SNU-16) through G2/M cell cycle arrest and PI3K/Akt signalling pathway. Amarogentin (AG) interacts with the α2 subunit of AMP-activated protein kinase (AMPK) and activates the trimeric kinase with EC50 of 277 pM.

S0672 AMAS AMAS is a non-cleavable heterobifunctional crosslinker with an NHS ester and maleimide groups. AMAS allows covalent conjugation of amine- and sulfhydryl-containing molecules.
S2097 Ambrisentan Ambrisentan (LU-208075, BSF-208075) is a highly selective antagonist of the endothelin-1 type A receptor, used in the treatment of pulmonary arterial hypertension (PAH).
S5710 Ambroxol Ambroxol, a substituted benzylamine, is an active metabolite of bromhexine. It is a potent inhibitor of the neuronal Na+ channels.
S3064 Ambroxol HCl AmbroxolHCl is a potent inhibitor of the neuronal Na+ channels, inhibits TTX-resistant Na+ currents with IC50 of 35.2 μM and 22.5 μM for tonic and phasic block, inhibits TTX-sensitive Na+ currents with IC50 of 100 μM. Phase 3.
S8572 Amcasertib (BBI503) Amcasertib (BBI503), a first-in-class cancer stemness kinase inhibitor, is claimed to inhibit Nanog and other CSC pathways by targeting kinases with potential anticancer activity.
S9609 Amcenestrant (SAR439859) Amcenestrant (SAR439859, compound 43d) is an orally available and nonsteroidal selective estrogen receptor degrader (SERD) with potential antineoplastic activity. SAR439859 is a potent estrogen receptor (ER) antagonist with EC50 of 0.2 nM for ERα degradation.
S5671 Amcinonide Amcinonide (Cyclocort, CL-34699) is an inhibitor of nitric oxide (NO) release from activated microglia with IC50 of 3.38 nM.
S2879 AMD3465 hexahydrobromide AMD3465 is a monomacrocyclic CXCR4 antagonist.
S6584 Amdinocillin Amdinocillin (Mecillinam, Coactin, FL 1060) is a β-lactam antibiotic with a broad spectrum of antibacterial activity. Amdinocillin is active alone against many gram-negative organisms.
S5552 Amenamevir Amenamevir (ASP2151) is a potent helicase-primase inhibitor and a novel class of antiviral agent.
S3833 Amentoflavone Amentoflavone (Didemethyl Ginkgetin) is a biflavonoid originally isolated from Selaginella with antibacterial, antioxidant, antiviral, antidiabetic, and neuroprotective activities.
S6462 Amezinium (methylsulfate) Amezinium is a sympathomimetic used for its vasopressor effects in the treatment of hypotensive states. It is a MAO inhibitor, antagonizes the response to tyramine and blocks neuronal uptake of noradrenaline.
S2452 Amfebutamone (Bupropion) HCl Amfebutamone (Bupropion) HCl is a selective norepinephrine-dopamine reuptake inhibitor with IC50 of 6.5 and 3.4 μM for the reuptake of dopamine and norepinephrine, respectively.
S4149 Amfenac Sodium Monohydrate Amfenac Sodium monohydrate is a non-steroidal analgesic anti-inflammatory drug with acetic acid moiety. The IC50 values for COX1 and COX2 is 250 nM and 150 nM, respectively.
S8167 AMG 337 AMG 337 is an oral, small molecule, ATP-competitive, highly selective inhibitor of the Met (c-Met) receptor with an IC50 of 1 nM.
S8682 AMG 487 AMG 487 is an orally active and selective CXC chemokine receptor 3 (CXCR3) antagonist that inhibits the binding of IP-10 (CXCL10) and ITAC (CXCL11) to CXCR3 with IC50 of 8.0 nM and 8.2 nM, respectively.
S0361 AMG-1 AMG-1 (c-Met/RON Dual Kinase Inhibitor, RON-IN-1) is a potent inhibitor of human c-Met and RON with IC50 of 4 nM and 9 nM, respectively.
S1316 AMG-208 AMG 208 is a highly selective dual c-Met and RON inhibitor with IC50 of 9 nM for c-Met.
S0362 AMG-25 AMG-25 is a novel potent and selective c-Kit inhibitor.
S6638 AMG-333 AMG-333 is a potent and highly selective antagonist of TRPM8 with IC50 values of 13 nM and 30 nM for human TRPM8 and rat TRPM8.
S2747 AMG-458 AMG 458 is a potent c-Met inhibitor with Ki of 1.2 nM, ~350-fold selectivity for c-Met than VEGFR2 in cells.
S2213 AMG-47a AMG-47a is a potent, nonselective inhibitor of Lck kinase with IC50 of 3.4 uM and it also inhibits T cell proliferation. AMG-47a exhibit anti-inflammatory activity (ED50) of 11 mg/kg in the anti-CD3-induced production of interleukin-2 (IL-2) in mice.
S7115 AMG-517 AMG 517 is a potent and selective TRPV1 antagonist, and antagonizes capsaicin, proton, and heat activation of TRPV1 with IC50 of 0.76 nM, 0.62 nM and 1.3 nM, respectively.
S2719 AMG-900 AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM. It is >10-fold selective for Aurora kinases than p38α, Tyk2, JNK2, Met and Tie2. Phase 1.
S6934 AMG-9810 AMG-9810 is potent, competitive and selective vanilloid receptor 1 (TRPV1) antagonist and inhibits capsaicin activation with IC50 of 24.5 nM and 85.6 nM for human TRPV1 and rat TRPV1, repectively. AMG-9810 blocks all known modes of TRPV1 activation, including protons-, heat-, and endogenous ligands, such as anandamide, N-arachidonyl dopamine, and oleoyldopamine. AMG-9810 significantly reduces the mRNA expression of TLR2 and TLR4. AMG-9810 also promotes mouse skin tumorigenesis mediated through EGFR/Akt/mTOR signaling.
S7813 AMG319 AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, >47-fold selectivity over other PI3Ks. Phase 2.
S5445 AMI-1 (free acid) AMI-1 is a potent and specific Histone Methyltransferase (HMT) inhibitor with IC50 of 3.0 μM and 8.8 μM for yeast Hmt1p and human PRMT1, respectively.
S4298 Amifostine trihydrate Amifostine trihydrate is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.
S3065 Amikacin disulfate Amikacin sulfate (BB-K8) binds to 16S rRNA (bacterial 30S ribosome), causing misreading of mRNA and supressing proteins synthesis.
S3122 Amikacin hydrate Amikacin is an aminoglycoside antibiotic used to treat different types of bacterial infections.
S5330 Amikacin Sulfate Salt Amikacin (BAY 41-6551) sulfate, a semisynthetic analog of kanamycin, is an aminoglycoside antibiotic which is very active against most gram-negative bacteria including gentamicin- and tobramycin-resistant strains.
S1811 Amiloride (MK-870) HCl Amiloride (MK-870) is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA)(Ki=7 μM).
S2560 Amiloride HCl dihydrate Amiloride HCl dihydrate is a potent epithelial sodium channel (ENaC) blocker, used in the management of hypertension and congestive heart failure.
S3218 Amiloxate Amiloxate (Amiloxiate, Isoamyl Methoxycinnamate, Isopentyl 4-methoxycinnamate, Isoamyl 4-methoxycinnamate, Isoamyl p-methoxycinnamate, Isopentyl p-methoxycinnamate) is EMA-approved chemical UV-filter used in cosmetics. Amiloxate is a cinnamic acid derivative with anti-inflammatory activity.
S1872 Amino-PEG1-C2-acid Amino-PEG1-C2-acid is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S0669 Amino-PEG2-C2-acid Amino-PEG2-C2-acid is a cleavable 3-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S1943 Amino-PEG2-NH-Boc Amino-PEG2-NH-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S0674 Amino-PEG3-C2-acid Amino-PEG3-C2-acid is a cleavable PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S1131 Amino-PEG3-C2-Amine Amino-PEG3-C2-Amine is a PEG-based PROTAC linker can be that is applicable to the synthesis of PROTACs.
S1931 Amino-PEG3-C2-Azido Amino-PEG3-C2-Azido is a PEG-based PROTAC linker that is applicable to the synthesis of the PARP1 degrader iRucaparib-TP3.
S1925 Amino-PEG3-CH2COOH Amino-PEG3-CH2COOH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S0567 Amino-PEG4-alcohol Amino-PEG4-alcohol is a PEG-based PROTAC linker used in the synthesis of PROTACs. Amino-PEG4-alcohol is a non-cleavable 4-unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
S1674 Amino-PEG4-Boc Amino-PEG4-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1306 Amino-PEG4-C2-amine Amino-PEG4-C2-amine is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S0593 Amino-PEG4-CH2COOH Amino-PEG4-CH2COOH is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. Amino-PEG4-CH2COOH is also a non-cleavable 4-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S1566 Amino-PEG5-amine Amino-PEG5-amine is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S0681 Amino-PEG6-alcohol Amino-PEG6-OH is a non-cleavable 6-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S1795 Amino-PEG7-amine Amino-PEG7-amine is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S0596 Amino-PEG8-Boc Amino-PEG8-Boc is a cleavable 8-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S1757 Amino-PEG9-amine Amino-PEG9-amine is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S0683 Aminoethyl-SS-ethylalcohol Aminoethyl-SS-ethylalcohol is an Alkyl-Chain-based PROTAC linker can be applied into the synthesis of PROTACs. Aminoethyl-SS-ethylalcohol is also a glutathione cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S1672 Aminoglutethimide Aminoglutethimide (BA-16038, NSC-330915) is an aromatase inhibitor with IC50 of 10 μM.
S4548 Aminoguanidine hydrochloride Aminoguanidine (Pimagedine, Guanyl hydrazine, Hydrazinecarboximidamide, Imino semicarbazide, Monoaminoguanidine) is a diamine oxidase and nitric oxide synthase inhibitor. It acts to reduce levels of advanced glycation end products (AGEs) through interacting with 3-deoxyglucosone.
S6129 Aminomalonic acid Aminomalonic acid (Aminomalonate, Aminopropanedioic acid) is an amino dicarboxylic acid. It has a role as a human metabolite and a Daphnia magna metabolite.
S1673 Aminophylline Aminophylline (Phyllocontin) is a competitive nonselective phosphodiesterase inhibitor with an IC50 of 0.12 mM and also a nonselective adenosine receptor antagonist.
E1003 Aminopterin Aminopterin (4-amino Folic Acid, 4-amino PGA, 4-Aminofolic acid, 4-Aminopteroylglutamic acid, Aminopteroylglutamic acid, APGA, NSC 739), a folic acid antagonist, is a competitive inhibitor of dihydrofolate reductase (DHFR) with Ki of 3.7 pM.
S4198 Aminothiazole Aminothiazole can be used as a thyroid inhibitor and it has antibacterial activity.
S1979 Amiodarone (NSC 85442) HCl Amiodarone (NSC 85442) HCl is a sodium/potassium-ATPase inhibitor and an autophagy activator, used to treat various types of cardiac dysrhythmias.
S0449 Amiselimod hydrochloride Amiselimod hydrochloride (MT-1303) is a novel modulator of sphingosine 1-phosphate receptor-1 (S1P1). Amiselimod hydrochloride reduces the bradycardia effects associated with fingolimod and other S1P receptor modulators.
S1280 Amisulpride Amisulpride (DAN-2163) is an atypical antipsychotic used to treat psychosis in schizophrenia and episodes of mania in bipolar disorder.
S3643 Amitraz Amitraz (NSC 324552) is a triazapentadiene, an α2 adrenergic agonist and a member of the amidine chemical family. It is a non-systemic acaricide and insecticide.
S5947 Amitriptyline Amitriptyline (MK-230, N-750, Ro41575) is a tricyclic antidepressant (TCA) with analgesic properties, widely used to treat depression and neuropathic pain. Amitriptyline is an inhibitor of both serotonin transporter (SERT) and norepinephrine transporter (NET) with Ki of 3.45 nM and 13.3 nM, respectively. Amitriptyline also inhibits histamine receptor H1, histamine receptor H4, 5-HT2 and sigma 1 receptor with Ki of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively. This product is a waxy solid.
S3183 Amitriptyline HCl Amitriptyline HCl is an inhibitor of both serotonin transporter (SERT) and norepinephrine transporter (NET) with Ki of 3.45 nM and 13.3 nM, respectively. Amitriptyline HCl also inhibits histamine receptor H1, histamine receptor H4, 5-HT2 and sigma 1 receptor with Ki of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively. Amitriptyline is a tricyclic antidepressant (TCA).
S3648 Amlexanox (AA-673) Amlexanox (AA-673, CHX-3673, Amoxanox) is an anti-inflammatory antiallergic immunomodulator and also an inhibitor of the protein kinases TBK1 and IKK-ε.
S1905 Amlodipine Amlodipine (UK-48340) is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain.
S1813 Amlodipine Besylate Amlodipine Besylate is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain.
S5966 Amlodipine maleate Amlodipine (Amvaz, UK-48340) maleate is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain.
E0151 Ammonium chloride

Ammonium chloride is an inorganic compound and can be used for establishing the rat model of renal calcium oxalate calculus.

E0375 Ammonium ferric citrate Ammonium ferric citrate (Ferric ammonium citrate, Ammonium iron(III) citrate, Iron ammonium citrate, FerriSeltz) induces ferroptosis in non-small-cell lung carcinoma through the inhibition of GPX4-GSS/GSR-GGT axis activity.
S6262 Ammonium formate Ammonium Formate is the ammonium salt of formic acid. It is widely used in various organic reactions.
S9143 Ammonium Glycyrrhizate Ammonium glycyrrhizate (Glycamil, Glycyrram) is an ammonium salt extract isolated from licorice root and is commonly used as a flavoring agent and is also used in fragrances, and skin and hair care products.
S2376 Ammonium Glycyrrhizinate Ammonium Glycyrrhizinate (AMGZ, Glycyram, Glycyrrhizin ammonium salt, Glycyrrhizic acid ammonium salt) is a unique product from Licorice root with a very high sweetness. Ammonium glycyrrhizinate is a direct inhibitor of HMGB1 with anti-inflammatory, anti-tumor, anti-diabetic activities. Ammonium Glycyrrhizinate inhibits growth and cytopathology of several unrelated DNA and RNA viruses. Ammonium Glycyrrhizinate also inhibits both hepatic delta 4-5-reductase and 11 beta-hydroxysteroid dehydrogenase.
S5625 Ammonium lactate Ammonium lactate (Lac-hydrin) is the ammonium salt of lactic acid with mild anti-bacterial properties.
S6485 AMN082 AMN082 is a selective, orally active, and brain-penetrant agonist of mGluR7 that directly activates receptor signaling via an allosteric site in the transmembrane domain. AMN082 potently inhibits cAMP accumulation and stimulates GTPγS binding with EC50 of 64-290 nM at transfected mammalian cells expressing mGluR7.
S5948 Amodiaquine Amodiaquine is a synthetic aminoquinoline that acts by binding to the protozoal or parasitic DNA and preventing DNA and RNA production and subsequent protein synthesis. It is used for the therapy of malaria.
S4589 Amodiaquine dihydrochloride dihydrate Amodiaquine is a potent, non-competitive inhibitor of histamine N-methyl transferase with estimated Ki of 18.6 nM. It is also used as an antimalarial and anti-inflammatory agent.
S5500 Amodiaquine hydrochloride Amodiaquine Hydrochloride is the hydrochloride salt of amodiaquine, an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory properties.
S1367 Amonafide Amonafide (NSC308847, AS1413) produces protein-associated DNA-strand breaks through a topoisomerase II-mediated reaction, but does not produce topoisomerase I-mediated DNA cleavage. Phase 3.
S1676 Amorolfine HCl Amorolfine HCl is an antifungal reagent.
S4218 Amoxapine Amoxapine (CL 67772) is a tricyclic dibenzoxazepine (an N-aryl piperazine) which acts similarly to several other tricyclic antidepressants, amoxapine inhibits GLYT2a transport activity with IC50 of 92 μM.
S3015 Amoxicillin Amoxicillin (Amoxycillin) is a moderate-spectrum, bacteriolytic, β-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms.
S2565 Amoxicillin Sodium Amoxicillin Sodium (Clavulanate) is a moderate- spectrum, bacteriolytic, β-lactam antibiotic.
S5298 Amoxicillin trihydrate Amoxicillin (Amoxil, Amoxipen, Moxaline) is a broad-spectrum, semisynthetic aminopenicillin antibiotic with bactericidal activity.
S3560 AMPA/kainate antagonist-2 AMPA/kainate antagonist-2 is a non-competitive antagonist of AMPA/kainate.
S0165 Ampalex (CX-516) Ampalex (CX-516, Ampakine CX 516, BDP-12, SPD 420) is a positive allosteric modulator of AMPA receptor. Ampalex exhibits potential treatment for Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI).
S1636 Amphotericin B Amphotericin B (AMB, NSC 527017) is an amphipathic polyene antibiotic which permeabilizes ergosterol-containing membranes.
S3170 Ampicillin sodium Ampicillin is a beta-lactam antibiotic that is part of the aminopenicillin family.
S4148 Ampicillin Trihydrate Ampicillin Trihydrate (NCI-C56086) is a β-lactam antibiotic, which inhibits bacterial cell-wall synthesis (peptidoglycan cross-linking) by inactivating transpeptidases on the inner surface of the bacterial cell membrane.
S4011 Ampiroxicam Ampiroxicam (CP 65703) is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug.
S1639 Amprenavir (VX-478) Amprenavir (VX-478, 141W94, KVX-478) is a potent PXR-selective agonist, and an HIV protease inhibitor, used to treat HIV.
S4144 Amprolium HCl Amprolium chloride is a thiamin antagonist, which prevents carbohydrate synthesis by blocking thiamine uptake.
S5627 Amsacrine hydrochloride Amsacrine hydrochloride (m-AMSA, acridinyl anisidide) is the hydrochloride salt form of amsacrine, which is an inhibitor of topoisomerase II with antineoplastic activity.
S1244 Amuvatinib (MP-470) Amuvatinib (MP-470, HPK 56) is a potent and multi-targeted inhibitor of c-Kit, PDGFRα and Flt3 with IC50 of 10 nM, 40 nM and 81 nM, respectively. Amuvatinib suppresses c-MET and c-RET. Amuvatinib is also active as a DNA repair protein Rad51 inhibitor with antineoplastic activity. Phase 2.
S2260 Amygdalin Amygdalin is a glycoside initially isolated from the seeds of the tree Prunus dulcis, also known as bitter almonds.
S6173 Amylmetacresol Amylmetacresol is an antiseptic used to treat infections of the mouth and throat.
A5317 Amyloid beta A4 Rabbit Recombinant mAb Amyloid beta A4 Rabbit Recombinant mAb detects endogenous level of total Amyloid beta A4.
S0308 AMZ30 AMZ30 (ML136, CS-2122) is a selective and covalent inhibitor of protein phosphatase methylesterase-1(PME-1) with IC50 of 0.60 μM. AMZ30 reduces the demethylated form of PP2A in living cells.
S3532 AN-2718 AN-2718 is an inhibitor of fungal growth that blocks protein synthesis via the oxaborole tRNA trapping (OBORT) mechanism.
S7582 Anacardic Acid Anacardic Acid (6-pentadecylsalicylic Acid) is a potent inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases, which also has antibacterial activity, antimicrobial activity, prostaglandin synthase inhibition, and tyrosinase and lipoxygenase inhibition.
S2748 Anacetrapib (MK-0859) Anacetrapib (MK0859) is a potent, selective, reversible rhCETP and mutant CETP(C13S) inhibitor with IC50 of 7.9 nM and 11.8 nM, increases HDL-C and decreases LDL-C, does not increase aldosterone or blood pressure. Phase 3.
S5909 Anagliptin Anagliptin is an orally active and highly selective dipeptidyl peptidase-4 (DPP-4) inhibitor and exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-κB activation.
S3172 Anagrelide HCl Anagrelide (BL-4162A) is a drug used for the treatment of essential thrombocytosis.
S4980 Anamorelin Anamorelin (ONO-7643, RC-1291, ST-1291) is an orally active, high-affinity, selective agonist of the ghrelin receptor with an EC50 value of 0.74 nM in the HEK293/GRLN FLIPR assay.
E0413 Anandamide

Anandamide (Arachidonoyl Ethanolamide) is an endogenous cannabinoid and TRPV1 receptor agonist with Ki values of 89 nM and 371 nM for CB1 and CB2 receptors respectively.

S1188 Anastrozole (ZD-1033) Anastrozole (ZD-1033) is a third-generation nonsteroidal selective aromatase inhibitor. It may offer greater selectivity compared with other aromatase inhibitors, being without any intrinsic endocrine effects and with no apparent effect on the synthesis of adrenal steroids.
S0295 Anavex 2-73 HCl Anavex 2-73 (Blarcamesine, AVex-73, AE-37), an aminotetrahydrofuran derivative, is a mixed muscarinic and sigma-1/σ1 Receptor agonist with IC50 of 0.86 μM.
S1140 Andarine Andarine (GTx-007, S-4) is a selective non-steroidal androgen receptor (AR) agonist with Ki of 4 nM, tissue-selective for anabolic organs. Phase 3.
S2261 Andrographolide Andrographolide is a labdane diterpenoid that is the main bioactive component of the medicinal plant Andrographis paniculata.
S6352 Androsterone Androsterone (5alpha-Androsterone) is a steroid metabolite derived from sex hormones, which displays weak androgenic properties.
S9081 Anemoside B4 Anemoside B4 (Pulchinenoside B4, Chinensioside A, Pulchinenoside C, Pulsatilla saponin B4), extracted from the herb of Pulsatilla chinensis (Bge.) Regel, is a potential antiviral constituent and inhibits the secretion of IL-10.
S4744 Anethole trithione Anethole trithione is a drug used in the treatment of dry mouth.
S3803 Angelic acid Angelic acid ((Z)-2-Methylbut-2-enoic acid) is a monocarboxylic unsaturated organic acid that is mostly found in the plants of the family Apiaceae.
S3806 Angelic anhydride Angelic anhydride (2-Methylisocrotonic Anhydride, (Z)-2-Methylbut-2-enoic anhydride) is a synthetic chemical and usually used in content determination assays and pharmacological experiments.
L5200 Angiogenesis Related compound Library A unique collection of 407 small molecules used for angiogenesis research targeting Bcr-Abl,BTK,HIF,VEGFR,FGFR,FAK,etc.
A5342 Angiopoietin 1 Rabbit Recombinant mAb Angiopoietin 1 Rabbit Recombinant mAb detects endogenous level of total angiopoietin 1.
S9820 Angiotensin (1-7) Angiotensin (1-7) (Ang-(1-7), Angiotensin fragment 1-7) is a bioactive component of the renin-angiotensin system that is formed endogenously from either Ang I or Ang II. Angiotensin (1-7) is a canine ACE inhibitor with an IC50 of 0.65 μM and inhibits the activity mediated by myostatin through Mas receptor.
P1085 Angiotensin II human Acetate Angiotensin II (angII) is an octapeptide hormone which affects the activities of heart, kidney, vasculature and brain. It works via binding to specific receptors present on cell membranes.
S9080 Anhydroicaritin Anhydroicaritin (Cycloicaritin), a prenylated flavonoid natural product, is commonly recognized as one of the effective compounds of Epimedii Herba and exhibits a variety of biological activities, such as activation of cancer cell apoptosis and inhibition of growth, protection against beta amyloid-induced neurotoxicity, and promotion of neuronal and cardiac cellular differentiation. It is a potent inhibitor of transcription factor SREBPs.
S4286 Anidulafungin (LY303366) Anidulafungin (LY303366), an echinocandin derivative, inhibits glucan synthase activity, used as an antifungal drug.
S1281 Aniracetam Aniracetam (RO 13-5057) is a nootropics and neuroprotective drug.
S9560 Anisodamine Hydrobromide Anisodamine (6-Hydroxyhyoscyamine) is a naturally occurring atropine derivative and exhibits anti-inflammatory activity. It also inhibits α1-adrenergic receptors and muscarinic acetylcholine receptors (mAChRs).
S5569 Anisole Anisole is a flavouring agent that is a precursor to perfumes, insect pheromones, and pharmaceuticals.
S7409 Anisomycin Anisomycin (Flagecidin, Wuningmeisu C) is a bacterial antibiotic isolated from Streptomyces griseolus, which inhibits protein synthesis, and also act as a JNK activator. Anisomycin upregulates autophagy and increases apoptosis.
S6782 Anle138b Anle138b is a novel oligomer modulator and an aggregation inhibitor, blocking the formation of pathological aggregates of prion protein (PrP(Sc)) and of α-synuclein (α-syn) with good oral bioavailability, blood-brain-barrier penetration and no detectable toxicity. Anle138b shows a new approach for disease-modifying therapy in neurodegenerative diseases such as prion and Parkinson's disease.
S8726 Anlotinib (AL3818) dihydrochloride Anlotinib (AL3818) is a highly potent and selective VEGFR2 inhibitor with IC50 less than 1 nM. It has broad-spectrum antitumor potential in clinical trials. Please use saline solution rather than PBS for dilutions. PBS may cause precipitation.
A5338 Annexin A10 Rabbit Recombinant mAb Annexin A10 Rabbit Recombinant mAb detects endogenous level of total annexin A10.
A5465 Annexin V Rabbit Recombinant mAb Annexin V Rabbit Recombinant mAb detects endogenous level of total Annexin V.
S0562 Ansamitocin P 3' Ansamitocin P 3' (Antibiotic C 15003P3', Maytansinol butyrate) is an antibody drug conjugate (ADC) cytotoxin, exhibiting antitumour activity.
S2447 Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222) Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222, Antibiotic C 15003P3) is a potent inhibitor of tubulin polymerization with IC50 of 3.4 μM.
S6141 Anserine Anserine (β-alanyl-N-methylhistidine) is a dipeptide containing β-alanine and 1-methylhistidine. It is normally absent from human tissues and body fluids, and its appearance there is an artifact of diet and serum carnosinase deficiency.
S0318 Ansofaxine hydrochloride Ansofaxine hydrochloride (LY03005, LPM570065) is a triple reuptake inhibitor that inhibits serotonin, dopamine and norepinephrine reuptake with IC50 of 723 nM, 491 nM and 763 nM, respectively.
E0164 Antazoline Phosphate

Antazoline Phosphate is the phosphate salt of antazoline. Antazoline is a first-generation antihistaminic agent and acts as a histamine H1 receptor antagonist.

S5168 Anthraquinone Anthraquinones (Anthradione, anthracenedione, dioxoanthracene) are the main active constituents in herbs often used to relieve constipation.
L6200 Anti-Aging Compound Library A unique collection of 2314 anti-aging compounds used for aging related research.
L5900 Anti-alzheimer Disease Compound Library A unique collection of 661 small molecules for exploring the mechanism of alzheimer's disease.
L3000 Anti-cancer Compound Library A unique collection of 3864 anti-cancer compounds for multiple cancers: Breast Cancer, Leukemia, Lung Cancer, Lymphoma, etc.
L7100 Anti-cancer Compound Library-Ⅱ A unique collection of 914 compounds with anticancer activity which has been verified by broad institute,half of the compounds are non-oncology drugs.
L5700 Anti-cancer Metabolism Compound Library A unique collection of 320 small molecules for cancer metabolism research.
L7500 Anti-Cardiovascular Disease Compound Library A unique collection of 698 anti-cardiovascular disease related compounds used for high throughput screening(HTS) and high content screening(HCS).
L2900 Anti-diabetic Compound Library A unique collection of 149 small molecules for exploring the development of diabetes.
A5712 Anti-Flag-tag Mouse Recombinant mAb

anti-Flag-tag Mouse Recombinant mAb detects the level of Flag-tagged target protein.

A2113 Anti-human/mouse TGF-β-InVivo The 1D11.16.8 monoclonal antibody reacts with mouse, human, rat, monkey, hamster, canine and bovine TGF-β (transforming growth factor beta) isoforms 1, 2 and 3.The 1D11.16.8 monoclonal antibody is a neutralizing antibody.
L3100 Anti-infection Compound Library A unique collection of 1396 anti-infection compounds with biological activity of antibacterial,antifungal,antiviral,etc.
A2110 Anti-mouse CD16/CD32-InVivo The 2.4G2 monoclonal antibody reacts specifically with mouse CD16 (FcγRIII) and CD32 (FcγRII). It has also been reported to react non-specifically via its Fc domain to FcγRI. The 2.4G2 antibody is commonly used in flow cytometry staining experiments to prevent non-specific binding of IgG to the FcγIII and FcγII, and possibly FcγI, receptors prior to staining with antigen specific primary antibodies.
A2107 Anti-mouse CD25 (IL-2Rα)-InVivo The PC-61.5.3 monoclonal antibody reacts with mouse IL-2Rα also known as CD25, Ly-43, p55, or Tac.The PC-61.5.3 antibody has been shown to inhibit the binding of IL-2 to both the low and high affinity IL-2 receptor forms. Additionally, the PC-61.5.3 antibody is commonly used to deplete CD4+FoxP3+ T regulatory cells in vivo.
A2108 Anti-mouse CD28-InVivo The PV-1 monoclonal antibody reacts with mouse CD28.The PV-1 antibody has been shown to stimulate the proliferation and cytokine production by activated T and NK cells.
A2104 Anti-mouse CD3ε-InVivo The 145-2C11 monoclonal antibody reacts with mouse CD3ε which is a 20 kDa transmembrane cell-surface protein that belongs to the immunoglobulin superfamily. The 145-2C11 antibody has been shown to induce T lymphocyte activation, proliferation, and apoptosis in vitro via binding and stimulating the TCR. When used in vivo the antibody is reported to produce T cell activation, anergy, or death.
A2101 Anti-mouse CD4-InVivo Anti-mouse CD4 antibody reacts with mouse CD4, which is a 55 kDa cell surface type I membrane glycoprotein. CD4 is a co-receptor of the T cell receptor (TCR) and assists the latter in communicating with antigen-presenting cells.
A2102 Anti-mouse CD8α-InVivo Anti-mouse CD8α reacts with mouse CD8α. CD8 is a transmembrane glycoprotein that acts as a co-receptor for the T cell receptor (TCR). It binds to class I MHC molecules displayed by antigen presenting cells (APC).
A2103 Anti-mouse CTLA-4 (CD152)-InVivo The UC10-4F10-11 monoclonal antibody reacts with mouse CTLA-4 (cytotoxic T lymphocyte antigen-4) also known as CD152. The UC10-4F10-11 antibody has been shown to promote T cell co-stimulation by blocking CTLA-4 binding to the B7 co-receptors, allowing for CD28 binding.
A2121 Anti-mouse IFNAR-1-InVivo Anti-mouse IFNAR-1-InVivo monoclonal antibody (Clone: MAR1-5A3) reacts with mouse IFNAR-1 (IFN alpha/beta receptor subunit 1). Anti-mouse IFNAR-1-InVivo has been shown to inhibit Type I IFN receptor signaling in vitro and in vivo.
A2105 Anti-mouse IFNγ-InVivo The R4-6A2 monoclonal antibody reacts with mouse IFNγ (interferon gamma) which is a 20 kDa soluble pleiotropic cytokine and the sole member of the type II class of interferons. The R4-6A2 antibody has been shown to neutralize both natural and recombinant IFNγ.
A2120 Anti-mouse IL-17A-InVivo Anti-mouse IL-17A-InVivo monoclonal antibody (Clone:17F3) reacts with mouse IL-17A which is a 15-20 kDa cytokine expressed by Th17 cells, γδ T cells, iNKT cells, NK cells, LTi cells, neutrophils, and intestinal Paneth cells. Anti-mouse IL-17A-InVivo has been shown to neutralize IL-17A in vivo.
A2109 Anti-mouse IL-4-InVivo The 11B11 monoclonal antibody reacts with mouse IL-4 (interleukin-4) which is a multifunctional 14 kDa cytokine.The 11B11 monoclonal antibody has been shown to neutralize the bioactivity of natural or recombinant IL-4.
A2118 Anti-mouse IL-6-InVivo Anti-mouse IL-6-InVivo monoclonal antibody (Clone:MP5-20F3) can reacts with mouse IL-6 (interleukin-6) which is a 21-28 kDa cytokine that is expressed by many cell types, including T lymphocytes, B lymphocytes, monocytes, fibroblasts, and endothelial cells. Anti-mouse IL-6-InVivo has been shown to neutralize the bioactivity of natural or recombinant IL-6.
A2114 Anti-mouse NK1.1-InVivo The PK136 monoclonal antibody reacts with mouse NK1.1 also known as CD161b/CD161c, KLRB1, NKR-P1A and Ly-55.
A2115 Anti-mouse PD-L1 (B7-H1)-InVivo Anti-mouse PD-L1 (B7-H1)-InVivo (Clone:10F.9G2) monoclonal antibody reacts with mouse PD-L1 (also known as B7-H1, CD274). The 10F.9G2 antibody has been shown to block the interaction between PD-L1 and PD-1 and between PD-L1 and B7-1 (CD80).
L8200 Anti-parasitic Compound Library A unique collection of 220 anti-parasitic compounds used for high throughput screening(HTS) and high content screening(HCS).
S4936 Antiarol Antiarol (3,4,5-trimethoxyphenol) is a member of aromatic phenols and exhibits moderate DPPH free radical scavenging activity.
L5300 Antibiotics compound Library A unique collection of 479 antibiotics used for anti- research in order to identify drug target and open up new mechanism and ways to treat human disease.
S4549 Antimonyl potassium tartrate trihydrate Antimonyl potassium tartrate trihydrate (Tartar emetic) is a powerful emetic, also used in the treatment of schistosomiasis and leishmaniasis.
S0323 Antineoplaston A10 Antineoplaston A10 is a naturally occurring substance in the human body that that can be potentially used for the treatment of glioma, lymphoma, astrocytoma and breast cancer. The main ingredient active of antineoplaston A10 (Phenylacetylglutamine, PG) inhibits RAS and promotes apoptosis.
L6500 Antioxidant Compound Library A unique collection of 421 compounds used for exploring the relationship between anti-oxidation and some diseases such as aging,cancer,alzheimer's disease,parkinson's disease,diabetes,etc.
S3173 Antipyrine Antipyrine (Phenazone) is an analgesic and antipyretic agent; selective COX-3 inhibitor.
L7000 Antiviral Compound Library A unique collection of 700 antiviral compounds used for exploring novel antiviral drug.
S9146 Anwuligan Anwuligan (Macelignan), a natural compound isolated from Myristica fragrans Houtt, has antimicrobial and anticariogenic activity against Streptococcus mutans and other streptococcus species. It also shows antioxidant, free radical scavenging, and neuroprotective activities.
S4989 AOA hemihydrochloride AOA hemihydrochloride (Aminooxyacetic acid, Carboxymethoxylamine, AOAA, Aminooxyacetate hemihydrochloride) is an inhibitor of aminobutyrate aminotransferase involved in amino acid and polyamine metabolism. AOA hemihydrochloride is also a CBS (cystathionine β-synthase) inhibitor.
S8487 AP20187 AP20187 (B/B Homodimerizer) is a chemical inducer of dimerization that activates FKBP-Casp8.
S7295 Apabetalone (RVX-208) Apabetalone (RVX-208, RVX-000222) is a potent BET bromodomain inhibitor with IC50 of 0.510 μM for BD2 in a cell-free assay, about 170-fold selectivity over BD1. Phase 2.
A5259 APAF1 Rabbit Recombinant mAb APAF1 Rabbit Recombinant mAb detects endogenous level of total APAF1.
S2840 Apalutamide (ARN-509) Apalutamide (ARN-509) is a selective and competitive androgen receptor inhibitor with IC50 of 16 nM in a cell-free assay, useful for prostate cancer treatment. Phase 3.
S5248 Apatinib Apatinib (Rivoceranib, YN968D1) is a potent inhibitor of the VEGF signaling pathway with IC50 values of 1 nM, 13 nM, 429 nM and 530 nM for VEGFR-2, Ret (c-Ret), c-Kit and c-Src, respectively. Apatinib induces both autophagy and apoptosis.
S2221 Apatinib (YN968D1) mesylate Apatinib mesylate (YN968D1, Rivoceranib) is a potent inhibitor of the VEGF signaling pathway with IC50 values of 1 nM, 13 nM, 429 nM and 530 nM for VEGFR-2, Ret (c-Ret), c-Kit and c-Src, respectively. Apatinib mesylate induces both autophagy and apoptosis.
S9605 Apcin Apcin (APC inhibitor) is an inhibitor of the E3 ligase activity of the mitotic anaphase-promoting complex/cyclosome (APC/C) that binds to Cdc20 and competitively inhibits the ubiquitylation of D-box-containing substrates.
S3177 Apcin-A

Apcin-A is an anaphase-promoting complex (APC) inhibitor that interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. Apcin-A can be used to synthesize the PROTAC CP5V.

S0110 APD597 APD-597 (JNJ-38431055) is a potent and selective G protein-coupled receptor 119 (GPR119) agonist with EC50 of 46 nM for hGPR119 and an inhibitor of Cytochrome P450 2C9 (CYP2C9) with IC50 of 5.8 μM. APD-597 (JNJ-38431055) is developed for treating Type 2 diabetes (T2D).
S6746 APD668 APD668 (JNJ28630368) is a potent GPR119 agonist with EC50s of 2.7 and 33 nM for human and rat forms, respectively.
P1211 Apelin-13

Apelin-13 can efficiently antagonize the APJ receptor with EC50 of 0.37 nM and result in suppress the forskolin-stimulated cAMP production.

S2262 Apigenin (LY 080400) Apigenin (NSC 83244, LY 080400) is a potent P450 inhibitor for CYP2C9 with Ki of 2 μM.
E0130 Apigenin-7-O-glucuronide

Apigenin-7-O-glucuronide (Apigenin-7-glucuronide) is the major flavonoid found in milk thistle. Apigenin 7-o-glucuronide inhibits tumor necrosis factor alpha (TNF-α) and total nitrite release in lipopolysaccharide-activated macrophages.

S9125 Apigetrin Apigetrin (Cosmetin, Cosmosioside, Thalictiin, Cosmosin, Apigenin 7-glucoside), a flavonoid found in many plant leaves and seeds, has been known to possess antimutagenic, anti-cancer, antioxidant and anti-inflammatory properties.
S6414 Apilimod (STA-5326) Apilimod (STA-5326) is a potent and orally-available inhibitor of the cytokines interleukin-12 (IL-12) and interleukin-23 (IL-23) with the potential to treat certain autoimmune and inflammatory diseases. Apilimod (STA-5326) inhibits IL-12 with IC50 of 1 nM, 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs, human monocytes and mouse PBMCs, respectively. Apilimod (STA-5326) is also a cell permeable small molecule that specifically inhibits PIKfyve with IC50 of 14 nM.
S0785 Apilimod (STA-5326) mesylate Apilimod (STA-5326) mesylate is a potent and orally-available inhibitor of the cytokines interleukin-12 (IL-12) and interleukin-23 (IL-23) with the potential to treat certain autoimmune and inflammatory diseases. Apilimod mesylate (STA-5326 mesylate) inhibits IL-12 with IC50 of 1 nM, 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs, human monocytes and mouse PBMCs, respectively. Apilimod mesylate (STA-5326 mesylate) is also a cell permeable small molecule that specifically inhibits PIKfyve with IC50 of 14 nM.
S2696 Apitolisib (GDC-0980) Apitolisib (GDC-0980, RG7422, GNE 390) is a potent, class I PI3K inhibitor for PI3Kα/β/δ/γ with IC50 of 5 nM/27 nM/7 nM/14 nM in cell-free assays, respectively. Also a mTOR inhibitor with Ki of 17 nM in a cell-free assay, and highly selective versus other PIKK family kinases. Apitolisib activates autophagy and apoptosis simultaneously in pancreatic cancer cells. Phase 2.
S1593 Apixaban (BMS 562247-01) Apixaban (BMS 562247-01) is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively.
S5846 Apocarotenal Apocarotenal is a carotenoid found in spinach and citrus fruits and plays a role as a precursor of vitamin A.
S2425 Apocynin (NSC 2146) Apocynin (NSC 2146, Acetovanillone, NSC 209524) is a selective NADPH-oxidase inhibitor with IC50 of 10 μM.
L3300 Apoptosis Compound Library A unique collection of 1235 small molecules used for apoptosis research targeting Bcl-2,Caspase,p53,TNF-alpha,Mdm2,survivin, etc.
S8365 Apoptozole Apoptozole (Apoptosis Activator VII) is an inhibitor of heat shock protein 70(HSP70) and Hsc70 with dissociation constants Kd of 0.14 μM and 0.21 μM, respectively. It induces caspase-dependent apoptosis.
S9705 Apostatin-1 Apostatin-1 (Apt-1) is a novel TRADD inhibitor. Apostatin-1 binds to a pocket on the N-terminal TRAF2-binding domain of TRADD (TRADD-N). Apostatin-1 inhibits bortezomib-induced apoptosis and RIPK1-dependent apoptosis (RDA) with an IC50 of about 1 μM.
S6583 Apraclonidine HCl Apraclonidine (Iopidine) is a sympathomimetic used in glaucoma therapy. It is an alpha2-adrenergic agonist.
E0021 Apraglutide (FE 203799)

Apraglutide (FE 203799) is a potent and highly selective GLP-2 agonist with EC50s of 0.03 nM and 0.07 nM for hGLP-2 Receptor and rGLP-2 Receptor, respectively.

S4254 Apramycin Sulfate Apramycin Sulfate (Ai3-29795) is an aminoglycoside antibiotic, which binds to the deep groove of the RNA.
S8034 Apremilast (CC-10004) Apremilast (CC-10004) is a potent and orally active PDE4 and TNF-α inhibitor with IC50 of 74 nM and 77 nM, respectively.
S1189 Aprepitant (MK-0869) Aprepitant (MK-0869, L-754030) is a potent and selective neurokinin-1 receptor antagonist with IC50 of 0.1 nM. Aprepitant reduces levels of pro-inflammatory cytokines including G-CSF, IL-6, IL-8 and TNFα. Aprepitant inhibits HIV infection of human macrophages.
S6450 Apronal Apronal (Apronalide, Allylisopropylacetylurea, Allylisopropylacetylcarbamide) is a hypnotic/sedative drug.
S7377 Aprotinin Aprotinin is a small protein serine protease inhibitor (Kd=0.06 pM for bovine β-trypsin), used to reduce perioperative blood loss and transfusion.
S3493 APS6-45 APS6-45 is an orally active tumor-calibrated inhibitor (TCI) that inhibits RAS/MAPK signaling and exhibits antitumor activity.
S6963 APTO-253

APTO-253 (LOR-253, LT-253) inhibits c-Myc expression and selectively induces CDKN1A (p21), promotes G0-G1 cell-cycle arrest, and triggers apoptosis in acute myeloid leukemia (AML) cells. APTO-253 is also an inducer of KLF4 (Krüppel-like factor 4).

S6623 APY29 APY29 is a type I kinase inhibitor of IRE1α that binds to the ATP-binding site on IRE1α and inhibits its autophosphorylation (IC50 = 280 nM) and enhances its RNase function (EC50 = 460 nM).
S3486 AQX-016A AQX-016A is a potent agonist of SHIP1. AQX-016A inhibits DNFB induced inflammation in a mouse ear edema/cutaneous anaphylaxis model.
S2244 AR-42 AR-42 (HDAC-42) is an HDAC inhibitor with IC50 of 30 nM. Phase 1.
S7435 AR-A014418 AR-A014418 (GSK-3β Inhibitor VIII) is an ATP-competitive, and selective GSK3β inhibitor with IC50 and Ki of 104 nM and 38 nM in cell-free assays, without significant inhibition on 26 other kinases tested.
S0101 AR231453 AR 231453 is a potent, orally-available and selective GPR119 agonist.
S6605 AR7 AR7 is a retinoic acid receptor α (RARα) antagonist.
S5580 Arabic gum Arabic gum, derived from exudates of Acacia senegal or Acacia seyal trees, is a complex polysaccharide indigestible to both humans and animals and considered as a safe dietary fiber.
S5570 Arachidic acid Arachidic acid (eicosanoic acid, Icosanoic Acid) is a natural saturated fatty acid used for the production of detergents, photographic materials and lubricants.
S6185 Arachidonic acid Arachidonic acid (Arachidonate) is an unsaturated, essential fatty acid found in animal and human fat as well as in the liver, brain, and glandular organs. It is a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes.
S0975 Araloside A Araloside A (Chikusetsusaponin IV), a component of Panax japonicus, is an inhibitor of renin with IC50 of 77.4 μM.
S2120 Arbidol HCl Arbidol HCl (Umifenovir) is a broad-spectrum antiviral compound that blocks viral fusion, used in treatment of influenza and other respiratory viral infections.
S2263 Arbutin Arbutin (Uva, p-Arbutin, β-Arbutin) is a tyrosinase inhibitor with IC50 of 0.9 mM and 0.7 mM for Monophenolase and Diphenolase, respectively.
S4738 Arctiin Arctiin (Arctigenin-4-Glucoside, NSC 315527) acts on an agonists of the adiponectin receptor 1 with anti-cancer effects.
S2614 Arecoline HBr Arecoline is a muscarinic acetylcholine receptor agonist.
S0943 Arenobufagin Arenobufagin is a natural bufadienolide from toad venom and induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway.
S5217 Arformoterol Tartrate Arformoterol Tartrate is the tartrate salt of arformoterol, a long-acting beta-2 adrenergic agonist with bronchodilator activity.
S2069 Argatroban (MCI-9038) Argatroban (MCI-9038) is a potent and selective synthetic thrombin inhibitor with Ki ranging from 5 nM to 39 nM, used as an anticoagulant.
S5074 Argatroban Monohydrate Argatroban (Argatroban hydrate, Argipidine) is a direct, selective thrombin inhibitor with anticoagulant effects.
S5946 Argireline Argireline is an innovative neuropeptide widely applied topically on the skin.
P1020 Argpressin Acetate Argpressin Acetate is a neurohypophysial hormone found in most mammals. It acts as a neurotransmitter at synapses in the brain, increases [Ca2+]i in cultured rat hippocampal neurons.
S1975 Aripiprazole Aripiprazole (OPC-14597) is a novel atypical antipsychotic drug that is reported to be a high-affinity 5-HT receptor partial agonist.
S9193 Aristolochic acid A Aristolochic acid A (Aristolochic Acid I, Aristolochin, Aristolochine, TR 1736) is a carcinogenic, mutagenic, and nephrotoxic agent extracted from the flowering plant family Aristolochiaceae.Aristolochic acid A significantly reduces both activator protein 1 (AP-1) and nuclear factor-κB (NF-κB) activities.
S8543 ARN-3236 ARN-3236 is a potent, orally available and selective inhibitor of salt-inducible kinase 2 (SIK2) with IC50 of <1 nM, 21.63 nM and 6.63 nM for SIK2, SIK1 and SIK3, respectively. ARN-3236 induces apoptosis in cancer cells.
S0410 ARN14974 ARN14974 is a benzoxazolone carboxamide inhibitor of acid ceramidase with IC50 of 79 nM.
S0157 ARN272 ARN272 is a FAAH-like anandamide transporter (FLAT) inhibitor.
A5282 Aromatase Rabbit Recombinant mAb Aromatase Rabbit Recombinant mAb detects endogenous level of total Aromatase.
S9909 ARP 100 ARP 100 (MMP-2 Inhibitor III, Compound 10a) is a potent and selective inhibitor of MMP-2 with an IC50 of 12 nM and displays less inhibitory activity at MMP-9, MMP-3, MMP-1 and MMP-7 with IC50s of 200 nM, 4500 nM, >50,000 nM and >50,000 nM respectively.
S7355 ARQ 621 ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1.
S3570 ARRY-382 ARRY-382 is a highly selective, oral inhibitor of the CSF1R with an IC50 of 9 nM.
S8707 ARS-1620 ARS-1620 is a potent, orally bioavailable covalent inhibitor of KRASG12C and could achieve rapid and sustained in vivo target occupancy to induce tumor regression.
S8156 ARS-853 (ARS853) ARS-853 is a selective, covalent KRAS(G12C) inhibitor that inhibits mutant KRAS-driven signaling by binding to the GDP-bound oncoprotein and preventing activation. ARS-853 also induces apoptosis.
S3889 Arteether Arteether is a well-known antimalarial drug which acts by producing free radicals within the malarial parasite.
S2264 Artemether Artemether (SM-224, CGP 56696) is an antimalarial for the treatment of resistant strains of falciparum malaria.
S9135 Artemisic acid Artemisic acid (Artemisinic acid), an amorphane sesquiterpene isolated from Artemisia annua L., has a variety of pharmacological activity, such as antimalarial activity, anti-tumor activity, antipyretic effect, antibacterial activity, allelopathy effect and anti-adipogenesis effect.
S1282 Artemisinin Artemisinin (Qinghaosu, Artemisinine) is a sesquiterpene endoperoxide which is a potent antimalarial agent.
S2265 Artesunate (WR-256283) Artesunate (WR-256283) is a part of the artemisinin group of agents with an IC50 of < 5 μM for small cell lung carcinoma cell line H69. It is a potential inhibitor of STAT-3 and exhibits selective cytotoxicity of cancer cells over normal cells in vitro; A potent inhibitor of EXP1.
S3150 Articaine HCl Articaine (Ultracaine) is a dental local anesthetic which contains an additional ester group that is metabolized by estearases in blood and tissue.
E0332 Arundic acid

Arundic acid (ONO-2506) is an astrocyte-modulating agent that delays the expansion of cerebral infarcts by modulating the activation of astrocytes through inhibition of S-100β synthesis.

S6965 ARV-110 ARV-110 is an orally bioavailable, specific androgen receptor (AR) PROTAC degrader that leads to ubiquitination and degradation of AR. ARV-110 completely degrades androgen receptor (AR) in all cell lines tested with DC50 of < 1 nM. ARV-110 can be used for the research of prostate cancer.
S8532 ARV-771 ARV-771 is a potent pan-(bromodomain and extra-terminal)BET degrader, a novel BET-PROTAC(proteolysis-targeting chimera) with Kd of 34 nM, 4.7 nM, 8.3 nM, 7.6 nM, 9.6 nM, and 7.6 nM for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1), and BRD4(2), respectively.
S8297 ARV-825 ARV-825 is a BRD4 Inhibitor that recruits BRD4 to the E3 ubiquitin ligase cereblon, leading to fast, efficient, and prolonged degradation of BRD4 and sustained down-regulation of MYC.
S6399 AS-041164 AS-041164 is a potent inhibitor of PI 3-kinase.
S5434 AS057278 AS057278 (3-Methylpyrazole-5-carboxylic acid, MPC) is an inhibitor of D-amino acid oxidase (DAAO).
S8301 AS101 AS101, a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta converting enzyme.
E0347 AS1269574

AS1269574 is a potent, orally available GPR119 agonist with an EC50 of 2.5 μM in HEK293 cells expressing human GPR119.

S8685 AS1517499 AS1517499 is a novel and potent STAT6 inhibitor with an IC50 value of 21 nM.
S8222 AS1842856 AS1842856 is a cell-permeable inhibitor that blocks the transcription activity of Foxo1 with IC50 of 33 nM. It could directly bind to the active Foxo1, but not the Ser256-phosphorylated form. AS1842856 suppresses autophagy.
E0400 AS1949490

AS1949490 is a potent and selective SHIP-2 inhibitor, with an IC50 of 620 nM. AS1949490 activates glucose metabolism via up-regulation of GLUT1 gene in L6 myotubes.

S8903 AS2863619 AS2863619 is a small-molecule cyclin-dependent kinase CDK8/19 inhibitor with IC50 of 0.6099 nM and 4.277 nM, respectively. AS2863619 is a potent Foxp3 inducer in Tconv cells.
S0099 Asapiprant Asapiprant (S-555739) is a potent and selective antagonist for DP1 receptor with Ki of 0.44 nM.
S2531 Asaraldehyde Asaraldehyde (Asaronaldehyde) is a natural COX-2 inhibitor, exhibiting 17-fold selectivity over COX-1.
S5467 Asarinin Asarinin (Sesamin, Fagarol, Pseudocubebin, Episesamin, Eleutheroside B4), isolated as a racemate from the shrub Zanthoxylum alatum, is usually used as a dietary fat-reduction supplement.
S8555 Asciminib (ABL001) Asciminib (ABL001) is a potent and selective allosteric ABL1 inhibitor with dissociation constant (Kd) of 0.5-0.8 nM and selectivity to the myristoyl pocket of ABL1.
S7411 Ascomycin (FK520) Ascomycin (FK520, FR 900520, Immunomycin), an FK-506 analog, is a neutral macrolide immunosuppressant, which prevents rejection after an organ transplant. Phase 3.
S1283 Asenapine maleate Asenapine maleate (Org 5222) is a high-affinity antagonist of serotonin, norepinephrine, dopamine and histamine receptors, used for the treatment of schizophrenia and acute mania associated with bipolar disorder.
A5240 ASH2L Rabbit Recombinant mAb ASH2L Rabbit Recombinant mAb detects endogenous level of total ASH2L.
S2266 Asiatic Acid Asiatic acid (Dammarolic acid, Asiantic acid) is the aglycone of asiaticoside isolated from the plant Centella asiatica, commonly used in wound healing.
S3616 Asiaticoside Asiaticoside (Ba 2742, BRN0078195, CCRIS8995, NSC166062, Emdecassol,Madecassol), the major active principle of Centella asiatica, prevents ultraviolet A-dependent photoaging by suppressing ultraviolet A-induced reactive oxygen species production. It also decreases DNA binding by MITF.
S0009 Asimadoline Asimadoline (EMD 61753) is a potent κ opioid receptor agonist with IC50 of 5.6 nM and 1.2 nM for guinea pig and human recombinant κ opioid receptor, respectively.
A5432 ASK1 Rabbit Recombinant mAb ASK1 Rabbit Recombinant mAb detects endogenous level of total ASK1.
S3401 ASK1-IN-1

ASK1-IN-1 is a CNS-penetrant inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with IC50 of 138 nM and 21 nM in cell-based assay and biochemical assay, respectively.

S9721 ASLAN003

ASLAN003 (LAS 186323) is a potent and orally active inhibitor of DHODH (Dihydroorotate dehydrogenase) with IC50 of 35 nM for human DHODH enzyme activity. ASLAN003 impairs protein synthesis and induces the differentiation and apoptosis transcriptional program in acute myeloid leukemia (AML) cells via activation of AP-1 transcription factors.

S3420 ASN03576800 ASN03576800 is an inhibitor of the VP40 matrix protein.
E0432 ASP-2905

ASP2905 is a potent and selective potassium channel Kv12.2 inhibitor.

S6749 ASP-9521 ASP-9521 is a selective, orally bioavailable inhibitor of 17beta-hydroxysteroid dehydrogenase type 5 (17β-HSD5).
S8054 ASP3026 ASP3026 is a novel and selective inhibitor for ALK with IC50 of 3.5 nM. Phase 1.
S8953 ASP4132 ASP4132 is a potent and orally active activator of Adenosine Monophosphate-Activated Protein Kinase (AMPK) with EC50 of 0.018 μM. ASP4132 is used as a clinical candidate for the treatment of human cancer.
S6539 ASP5878 ASP5878 is a novel FGFR-selective inhibitor with IC50 values of 0.47, 0.60, 0.74, and 3.5 nmol/L for recombinant FGFR1, 2, 3, and 4, respectively.
S0447 ASP7663 ASP7663 is an orally bioavailable selective activator of transient receptor potential ankyrin 1 (TRPA1). ASP7663 activates human, rat and mouse TRPA1 receptors with EC50 of 510 nM, 540 nM and 500 nM, respectively. ASP7663 acts by stimulating 5-HT release from QGP-1 cells and exhibiting an abdominal analgesic effect in vivo.
S2036 Aspartame Aspartame (SC-18862) is an artificial, non-saccharide sweetener used as a sugar substitute in some foods and beverages.
S9051 Asperuloside Asperuloside, an iridoid glycoside found in Herba Paederiae, is a component from traditional Chinese herbal medicine and exerts anti-inflammatory effect.
S3017 Aspirin (NSC 27223) Aspirin (NSC 27223, Acetylsalicylic acid, ASA) is a salicylate, and irreversible COX1 and COX2 inhibitor, used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication. Aspirin induces autophagy and stimulates mitophagy.
S6662 AST-487 (NVP-AST487) AST-487 (NVP-AST487), a N,N'-diphenyl urea,is an ATP competitive inhibitor of Flt3 with ki of 0.12 μM.Besides FLT3, AST487 also inhibits RET,KDR,c-KIT,and c-ABL kinase with IC50 values below 1 μM.
S5984 AST5902 trimesylate AST5902 is the principal metabolite of alflutinib both in vitro and in vivo, which exerts remarkable antineoplastic activity similar to alflutinib. AST5902 exhibits much weak CYP3A4 induction potential compared to alflutinib.
S3834 Astaxanthin Astaxanthin (β-Carotene-4,4'-dione, Trans-Astaxanthin), a xanthophyll carotenoid, is a nutrient with unique cell membrane actions and diverse clinical benefits with excellent safety and tolerability. Astaxanthin, a red dietary carotenoid isolated from Haematococcus pluvialis, is a modulator of PPARγ and a potent antioxidant with antiproliferative, neuroprotective and anti-inflammatory activity.
S0398 Astemizole Astemizole (R 43512) is a histamine H1-receptor antagonist with IC50 of 4.7 nM. Astemizole is also a potent inhibitor of ether à-go-go 1 (Eag1) and Eag-related gene (Erg) potassium channels. Astemizole has antineoplastic and antipruritic effects.
S3932 Astilbin Astilbin (Isoastilbin, Neoastilbin, Neoisoastilbin, Taxifolin 3-O-rhamnoside), a flavonoid compound isolated from the rhizome of Smilax glabra Roxb, displays anticancer, antioxidative, anti-inflammatory, and immunosuppressive activities.
S9289 Astragalin Astragalin (kaempferol-3-glucoside, Kaempferol 3-O-glucoside, Kaempferol 3-D-glucoside), a flavonoid from leaves of persimmon and green tea seeds, has anti-tumor, anti-inflammatory and anti-oxidant activities.
S3901 Astragaloside IV Astragaloside IV (AST-IV, AS-IV) is a bioactive saponin first isolated from the dried plant roots of the genus Astragalus, which is used in traditional Chinese medicine. It has various effect on the cardiovascular, immune, digestive, and nervous systems. AS-IV suppresses activation of p-Akt, p-mTOR, p-NF-κB and p-Erk1/2.
S9014 AstragalosideⅠ AstragalosideⅠ, is a bioactive saponin first isolated from the dried plant roots of the genus Astragalus, which is used in traditional Chinese medicine.
S0962 Astrapterocarpan glucoside Astrapterocarpan glucoside (Methylnissolin-3-O-glucoside) is a flavonoid extracted from the roots of Astragalus membranaceus with anti-inflammatory effects.
S0872 ASTX-029 ASTX-029 is an orally bioavailable inhibitor of the extracellular signal-regulated kinases (ERK) 1 and 2, with potential antineoplastic activity. ASTX-029 inhibits ERK-dependent tumor cell proliferation and survival.
S4935 Asunaprevir (BMS-650032) Asunaprevir (BMS-650032) is an orally bioavailable inhibitor of the hepatitis C virus enzyme serine protease NS3 that is necessary for protein processing required for viral replication.
S0878 AT-001 AT-001 (Aldose reductase-IN-1) is an aldose reductase inhibitor with IC50 of 28.9 pM.
S0805 AT-007 AT-007 is an orally active central nervous system (CNS) penetrant inhibitor of Aldose Reductase. AT-007 is used for the treatment of Galactosemia with IC50 of 100 pM.
E0093 AT-130

AT-130, a non-nucleoside inhibitor of HBV. AT-130 inhibits HBV DNA replication in hepatoma cells but had no effect on viral DNA polymerase activity or core protein translation.

S9678 AT-56 AT-56 is an orally active and selective inhibitor of lipocalin-type prostaglandin (PG) D synthase (L-PGDS) with Ki of 75 μM and IC50 of 95 μM.
S7563 AT13148 AT13148 is an oral, ATP-competitive, multi-AGC kinase inhibitor with IC50 of 38 nM/402 nM/50 nM, 8 nM, 3 nM, and 6 nM/4 nM for Akt1/2/3, p70S6K, PKA, and ROCKI/II, respectively. Phase 1.
S1524 AT7519 AT7519 is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9 with IC50 of 10-210 nM. It is less potent to CDK3 and little active to CDK7. AT7519 also inhibits GSK3β with IC50 of 89 nM. AT7519 induces apoptosis. Phase 2.
S7808 AT7519 HCl AT7519 HCl is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9 with IC50 of 10-210 nM in cell-free assays. It is less potent to CDK3 and little active to CDK7. Phase 2.
S1558 AT7867 AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM in cell-free assays, respectively; little activity outside the AGC kinase family.
S1134 AT9283 AT9283 is a potent JAK2/3 inhibitor with IC50 of 1.2 nM/1.1 nM in cell-free assays; also potent to Aurora A/B, Abl1(T315I). Phase 2.
S6983 Ataciguat Ataciguat, an anthranilic acid derivative, activates the oxidized form of sGC.
S6003 Ataluren (PTC124) Ataluren (PTC124) selectively induces ribosomal read-through of premature but not normal termination codons, with EC50 of 0.1 μM in HEK293 cells, may provide treatment for genetic disorders caused by nonsense mutations (e.g. CF caused by CFTR nonsense mutation). Phase 3.
S8993 Atamparib (RBN-2397) Atamparib (RBN-2397) is a potent, selective and orally active NAD+ competitive inhibitor PARP7 with IC50 of <3 nM and Kd of <0.001 μM. RBN-2397 has the potential for the research of tumor treatment.
S4662 Atazanavir Atazanavir (Latazanavir, Zrivada, Reyataz, BMS-232632) is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents. Atazanavir is a substrate and inhibitor of cytochrome P450 isozyme 3A (CYP3A4) and an inhibitor and inducer of P-glycoprotein.
S1457 Atazanavir (BMS-232632) Sulfate Atazanavir Sulfate (BMS-232632) is a HIV protease inhibitor with Ki of 2.66 nM in a cell-free assay.
S6615 ATB 346 ATB 346, a novel hydrogen sulphide-releasing derivative of naproxen with remarkably reduced toxicity, inhibits COX activity. ATB 346 is an anti-inflammatory agent that induces apoptosis of human melanoma cells.
S4817 Atenolol Atenolol (Tenormin, Normiten, Blokium) is a selective β1 receptor antagonist with log Kd values of −6.66±0.05, −5.99±0.14, −4.11±0.07 for binding to the human β1-, β2- and β3-adrenoceptors.
A2004 Atezolizumab (anti-PD-L1) Atezolizumab (anti-PD-L1) is a fully humanized, IgG1 monoclonal antibody that blocks the interaction of PD-L1 with both PD-1 and B7.1, but not the interaction of PD-L2 with PD-1. MW : 145 KD.
A5083 ATF1 Rabbit Recombinant mAb ATF1 Rabbit Recombinant mAb detects endogenous levels of ATF1.
A5041 ATF2 Rabbit Recombinant mAb

ATF2 Antibody detects endogenous levels of total ATF2.

A5514 ATF4 Rabbit Recombinant mAb ATF4 Rabbit Recombinant mAb detects endogenous level of total ATF4.
A5516 Atg4A Rabbit Recombinant mAb Atg4A Rabbit Recombinant mAb detects endogenous level of total Atg4A.
A5151 Atg4B Rabbit Recombinant mAb Atg4B Rabbit Recombinant mAb detects endogenous level of Atg4B.
A5123 ATG9A Rabbit Recombinant mAb ATG9A Rabbit Recombinant mAb detects endogenous level of total ATG9A.
S0089 ATH686 ATH686 is a potent, selective and second-generation FLT3 Inhibitor.
S8309 ATI-2341 ATI-2341, pepducin targeting the C-X-C chemokine receptor type 4 (CXCR4), is an allosteric agonist activating the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization.
S4650 Atipamezole Atipamezole (MPV-1248, MPV1248, Antisedan) is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug.
S4649 Atipamezole hydrochloride Atipamezole (Antisedan, MPV1248) is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug. Atipamezole hydrochloride is hydrochloride form of atipamezole.
S8454 ATN-161 (Ac-PHSCN-NH2) ATN-161 (Ac-PHSCN-NH2) is a novel small peptide antagonist of integrin α5β1. It binds to several integrins, including α5β1 and αvβ3, that play a role in angiogenesis and tumor progression.
S3175 Atomoxetine HCl Atomoxetine (LY 139603) is a selective norepinephrine (NE) transporter inhibitor with Ki of 5 nM, with 15- and 290-fold lower affinity for human 5-HT and DA transporters.
S0342 Atopaxar Atopaxar (E5555, ER-172594-00) is a potent and orally-active inhibitor of Protease-activated receptor-1 (PAR-1). E5555 inhibited the binding of a high-affinity thrombin receptor-activating peptide ([(3)H]haTRAP) to PAR-1 with IC50 of 0.019μM.
S5715 Atorvastatin Atorvastatin is a lipid lowering agent. It is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-determining enzyme in cholesterol biosynthesis via the mevalonate pathway. Atorvastatin activates autophagy.
S2077 Atorvastatin Calcium Atorvastatin Calcium is an inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol. Atorvastatin Calcium induces apoptosis and autophagy.
S3079 Atovaquone Atovaquone (Atavaquone) is a medication used to treat or prevent for pneumocystis pneumonia, toxoplasmosis, malaria, and babesia.
S5260 ATP ATP (Adenosine-Triphosphate, Adenosine 5'-triphosphate) is a multifunctional nucleoside triphosphate and an important endogenous signaling molecule in immunity and inflammation.
A5181 ATP citrate lyase Rabbit Recombinant mAb ATP citrate lyase Rabbit Recombinant mAb detects endogenous level of total ATP citrate lyase.
S1985 ATP disodium ATP Disodium (Adenosine-Triphosphate disodium, ATP disodium salt, Adenosine 5'-triphosphate) is a disodium salt form of adenosine-triphosphate which is a multifunctional nucleoside triphosphate.
S3567 ATP synthase inhibitor 1 ATP synthase inhibitor 1 is a potent inhibitor of c subunit of the F1/FO-ATP synthase complex that inhibits mitochondrial permeability transition pore (mPTP) opening.
A5288 ATP5A1 Rabbit Recombinant mAb ATP5A1 Rabbit Recombinant mAb detects endogenous level of total ATP5A1.
A5286 ATPB Rabbit Recombinant mAb ATPB Rabbit Recombinant mAb detects endogenous level of total ATPB.
S9314 Atractylenolide II Atractylenolide II (AT-II, Asterolide, 2-Atractylenolide), a major sesquiterpenoids isolated from the dried Rhizome of Atractylodes macrocephala, shows a wide range of biological and pharmacological activities, for example, against insomnia and anxiety, neuroprotective, platelet activation and anti-cancer effect.
E0008 Atractylodin Atractylodin (Atractydin) is one of the major constituents of the rhizome of Atractylodes lancea and inhibits N-acylethanolamine-hydrolyzing acid amidase (NAAA) activity with an IC50 of 2.81 µM. Atractylodin also inhibits interleukin-6 (IL-6) by blocking NPM-ALK activation and MAPKs.
S3264 Atractyloside potassium salt Atractyloside potassium salt (ATR potassium salt), a toxic diterpenoid glycoside isolated from the fruits of Xanthium sibiricum (Cang'erzi), is a powerful and specific inhibitor of mitochondrial ADP/ATP carriers. Atractyloside potassium salt inhibits chloride channels from mitochondrial membranes of rat heart.
S1832 Atracurium Besylate Atracurium Besylate (BW 33A, 51W89) is a neuromuscular blocking agent with ED95 of 0.2 mg/kg.
S5171 Atrazine Atrazine (Chromozin, Oleogesaprim, Aktikon, Gesaprim) is a selective triazine herbicide. Atrazine is also a potent endocrine disruptor that is active at low, ecologically relevant concentrations.
S4713 Atropine Atropine (Atropen, Atnaa, Tropine tropate, DL-Hyoscyamine) is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with anti-myopia effect.
S5493 Atropine sulfate Atropine Sulfate (Sulfatropinol, Atropette, Tropintran) is the sulfate salt of atropine, which is a natural alkaloid anticholinergic agent and has potent antimuscarinic effects.
S2130 Atropine sulfate monohydrate Atropine sulfate monohydrate is a competitive antagonist for the muscarinic acetylcholine receptor, used to decrease the production of saliva and secretions of the airway prior to surgery.
E0320 Atuliflapon (AZD5718)

Atuliflapon (AZD5718) is an orally active inhibitor of FLAP with an IC50 of 2 nM.

S8727 Atuveciclib (BAY-1143572) Atuveciclib (BAY-1143572) is potent and highly selective PTEFb/CDK9 inhibitor with IC50 values of 13 nM for CDK9/CycT and the ratio of IC50 values for CDK2/CDK9 is about 100. Outside the CDK family, It inhibits GSK3 kinase with IC50 values of 45 nM and 87 nM for GSK3α and GSK3β respectively.
S0464 AU1235 AU1235, an adamantyl urea, is a potent inhibitor of Mycobacterium tuberculosis protein MmpL3.
S5459 Aucubin Aucubin (Rhinanthin), an iridoid glycoside existing in medicinal plants, has been reported to show an anti-inflammatory activity by suppression of TNF-α production in murine macrophages.
S0752 AUDA AUDA (compound 43) is a potent inhibitor of soluble epoxide hydrolase (sEH) with IC50 of 18 nM and 69 nM for the mouse sEH and human sEH, respectively. AUDA has anti-inflammatory activity that reduces the protein expression of MMP-9, IL-1β, TNF-α and TGF-β. AUDA downregulates Smad3 and p38 signaling pathways.
S8549 AUNP-12 AUNP-12 (Aur-012, Aurigene-012, Aurigene NP-12), a new immune checkpoint modulator, is an inhibitor of the PD-1 pathway.
S4307 Auranofin Auranofin (Ridaura, SKF-39162) is an inhibitor of thioredoxin reductase (TrxR) with IC50 of 88 nM for purified H. pylori TrxR in cell-free assay. Auranofin has anti-cancer activity and can completely inhibit bacterial growth at 1.2 μM. Auranofin is an FDA-approved gold-containing compound used for the treatment of rheumatoid arthritis.
S9052 Auraptene Auraptene (7-geranyloxycoumarin) is a natural coumarin derived from citrus plants and possesses valuable pharmacological properties, including anticarcinogenic, anti-inflammatory, antihelicobacter, antigenotoxic, and neuroprotective effects. Auraptene inhibits matrix metalloproteinase 2 (MMP-2) as well as key inflammatory mediators, including IL-6, IL-8 and chemokine (C-C motif) ligand-5(CCL5).
S0561 Auristatin E Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity. Auristatin E is an MMAE analog and cytotoxin in Antibody-drug conjugates (ADCs). Auristatin E inhibits cell division by blocking the polymerisation of tubulin.
S1451 Aurora A Inhibitor I (TC-S 7010) Aurora A Inhibitor I (TC-S 7010) is a novel, potent, and selective inhibitor of Aurora A with IC50 of 3.4 nM in a cell-free assay. It is 1000-fold more selective for Aurora A than Aurora B. Aurora A Inhibitor I (TC-S 7010) triggers apoptosis through the ROS-mediated UPR signaling pathway.
A5065 Aurora A Rabbit Recombinant mAb Aurora A Rabbit Recombinant mAb detects endogenous levels of total Aurora A.
A5118 Aurora B Rabbit Recombinant mAb Aurora B Rabbit Recombinant mAb detects endogenous levels of total Aurora B.
E0342 Aurora kinase Inhibitor II

Aurora kinase Inhibitor II is a selective and ATP-competitive Aurora kinase inhibitor with IC50s of 310 nM and 240 nM for Aurora A and Aurora B, respectively.

S2931 Aurora Kinase Inhibitor III Aurora kinase inhibitor III is a potent inhibitor of Aurora A kinase with an IC50 of 42 nM and has high selectivity for Aurora A over BMX, BTK, IGF-1R, c-Src, TRKB, SYK, and EGFR (IC50s = 386, 3,550, 591, 1,980, 2,510, 887, and >10,000 nM, respectively).
L2600 Autophagy Compound Library A unique collection of 1025 small molecules with autophagy-inducing or autophagy-inhibiting activity.
S8596 Autophinib Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay and rapamycin induced autophagy assay. The IC50 value for Vps34 is 19 nM in vitro.
S6960 Auxinole Auxinole is a potent auxin antagonist of TIR1/AFB receptors that binds TIR1 to block the formation of the TIR1-IAA-Aux/IAA complex. Auxinole inhibits auxin-responsive gene expression.
S0474 Avacopan (CCX168) Avacopan (CCX168) is an orally administered and selective C5a receptor (C5aR) antagonist.
S7892 Avadomide (CC-122) Avadomide (CC-122), a new chemical entity termed pleiotropic pathway modifier, is a novel agent for Diffuse large B-cell lymphoma(DLBCL) with antitumor and immunomodulatory activity. Its molecular target is the protein cereblon (CRBN), a substrate receptor of the cullin ring E3 ubiquitin ligase complex CRL4CRBN.
S1262 Avagacestat (BMS-708163) Avagacestat (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, demonstrating a 193-fold selectivity against Notch. Phase 2.
S4019 Avanafil Avanafil is a highly selective PDE5 inhibitor with IC50 of 5.2 nM, >121-fold selectivity over other PDEs.
S8553 Avapritinib (BLU-285) Avapritinib (BLU-285) is a small molecule kinase inhibitor that potently inhibits PDGFRα D842V mutant activity in vitro (IC50 = 0.5 nM) and PDGFRα D842V autophosphorylation in the cellular setting (IC50 = 30 nM); also a potent inhibitor of the analogous Kit (c-Kit) mutation, D816V in Kit (c-Kit) Exon 17 (IC50 = 0.5 nM).
S2187 Avasimibe (CI-1011) Avasimibe (CI-1011, PD-148515) inhibits ACAT with IC50 of 3.3 μM, also inhibits human P450 isoenzymes CYP2C9, CYP1A2 and CYP2C19 with IC50 of 2.9 μM, 13.9 μM and 26.5 μM, respectively.
S6624 Avatrombopag Avatrombopag is an orally administered, small-molecule thrombopoietin receptor (c-Mpl) agonist which increases platelet number, but not platelet activation.
A2015 Avelumab (anti-PD-L1) Avelumab (anti-PD-L1) (Bavencio, MSB0010718C) is a fully human IgG1 monoclonal antibody that targets the protein programmed death-ligand 1 (PD-L1). Avelumab exhibits potential antibody-dependent cell-mediated cytotoxicity and is used for the treatment of several kinds of carcinoma. MW=143.8 kDa.
S4999 Avermectin B1 Avermectin B1 (Abamectin) is a widely used insecticide and anthelmintic.
P1203 Avexitide Avexitide (Exendin (9-39)) is a specific and competitive antagonist of glucagon-like peptide-1 (GLP-1) receptor.
S3732 Avibactam sodium Avibactam (AVE-1330A, NXL104) is a covalent, reversible, non-β-lactam β-lactamase inhibitor with IC50 values of 8, 80, and 38 nM for TEM-1, P99, and KPC-2 β-lactamases, respectively.
S8741 Avitinib (AC0010) Avitinib (AC0010) is a pyrrolopyrimidine-based irreversible EGFR inhibitor that is mutation-selective with IC50 value of 0.18 nM against EGFR L858R/T790M double mutations, nearly 43-fold greater potency over wild-type EGFR (IC50 value, 7.68 nM). It has comparable anti-tumor activity and tolerated toxicity.
S0098 AVN-492 AVN-492 is a novel highly selective 5-HT6R Antagonist with Ki of 91 pM.
S1904 Avobenzone Avobenzone (Butyl methoxydibenzoylmethane, BF2AVB) is an oil soluble ingredient used in sunscreen products to absorb the full spectrum of UVA rays and a dibenzoylmethane derivative.
S5319 AWD 131-138 AWD 131-138 (Imepitoin, ELB-138) is a centrally acting anti-epileptic which crosses the blood brain barrier and is used for the treatment of canine idiopathic epilepsy. AWD 131-138 (Imepitoin) is an antiepileptic and antianxietic drug, AWD 131-138 can stimulate different recombinant isoforms of the rat GABA(A) receptor through the benzodiazepine binding site.
S0799 AWZ1066S AWZ1066S is a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis with EC50 of 2.5 nM in cell-based assay.
S6727 AX-024 HCl AX-024 HCl blocks the interaction of the CD3ε PRS with SH3.1(Nck). AX-024 HCl also inhibits IL-6, TNF-α, IFN-γ, IL-10 and IL-17A.
S1005 Axitinib (AG 013736) Axitinib (AG 013736) is a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ and c-Kit with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM in Porcine aorta endothelial cells, respectively.
E0096 AZ 11645373

AZ 11645373 is a potent and selective human P2X7 antagonist with KB values of 5-7 nM and > 10,000 nM for hP2X7 and rP2X7 respectively.

S2731 AZ 3146 AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM, contributes to recruitment of CENP-E (kinesin-related motor protein), less potent to FAK, JNK1, JNK2, and Kit.
S2746 AZ 628 AZ628 is a new pan-Raf inhibitor for BRAF, BRAFV600E, and c-Raf-1 with IC50 of 105 nM, 34 nM and 29 nM in cell-free assays, also inhibits VEGFR2, DDR2, Lyn, Flt1, FMS, etc. AZ628 induces apoptosis.
S2214 AZ 960 AZ 960 is a novel ATP competitive JAK2 inhibitor with IC50 and Ki of <3 nM and 0.45 nM, 3-fold selectivity of AZ960 for JAK2 over JAK3. AZ 960 induces apoptosis and growth arrest.
S0108 AZ-33 AZ-33 (LDHA Inhibitor 33) is a potent inhibitor of lactate dehydrogenase A (LDHA) with IC50 of 0.5 μM. LDHA is the key enzyme involved in anaerobic glycolysis which is frequently deregulated in human malignancies.
S3520 AZ10606120 dihydrochloride AZ10606120 dihydrochloride (2HCl) is a potent and selective antagonist for P2X7 receptor (P2X7R) with IC50 of ~10 nM. AZ10606120 dihydrochloride exhibits anti-depressant effects and reduces tumour growth.
S8755 AZ304 AZ304 is a synthetic inhibitor designed to interact with the ATP-binding site of wild type and V600E mutant BRAF with IC50 values of 79 nM and 38 nM, respectively. It also inhibits CRAF, p38 and CSF1R at sub 100 nM potencies.
S8729 AZ32 AZ32 is a specific inhibitor of the ATM kinase that possesses good BBB penetration in mouse with an IC50 value of <0.0062 μM for ATM enzyme. It shows adequate selectivity over ATR and also has high cell permeability.
S9744 AZ3451 AZ3451 is a potent antagonist of protease-activated receptor 2 (PAR2) that binds to a remote allosteric site outside the helical bundle with IC50 of 23 nM.
S7298 AZ5104 AZ5104, the demethylated metabolite of AZD-9291, is a potent EGFR inhibitor with IC50 of <1 nM, 6 nM, 1 nM, and 25 nM for EGFR (L858R/T790M), EGFR (L858R), EGFR (L861Q), and EGFR (wildtype), respectively. Phase 1.
S6427 AZ876 AZ876 is a novel high-affinity Liver X Receptor (LXR) agonist with Ki values of 0.007 μM and 0.011 μM for human LXRα and LXRβ respectively.
S0364 AZ9482 AZ9482 is a potent and selective inhibitor of PARP featuring an amide linkage to a 2-piperazinyl-3-cyano-pyridine. AZ9482 exhibits very potent centrosome declustering activity with EC50 of < 18 nM in HeLa cells.
S3379 AZA1

AZA1 (Rac1/Cdc42-IN-1) is a potent dual inhibitor of Rac1 and Cdc42 that induces prostate cancer cells apoptosis and inhibits prostate cancer cells proliferation, migration and invasion.

S1782 Azacitidine (5-Azacytidine) Azacitidine (5-Azacytidine, 5-AzaC, Ladakamycin, AZA, 5-Aza, CC-486) is a nucleoside analogue of cytidine that specifically inhibits DNA methylation by trapping DNA methyltransferases. Azacitidine induces mitochondrial apoptosis and autophagy.
S3196 Azacyclonol Azacyclonol (MER 17, MDL 4829), also known as γ-pipradol, is a drug used to diminish hallucinations in psychotic individuals.
S4194 Azaguanine-8 Azaguanine-8 (NSC-749, SF-337, SK 1150) is a purine analogs showing antineoplastic activity by competing with guanine in the metabolism.
S6636 Azaindole 1 (TC-S 7001) Azaindole 1 (TC-S 7001) is a selective Rho-associated protein kinase (ROCK) inhibitor with IC50 of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2 in an ATP-competitive manner.
S5085 Azamethiphos Azamethiphos is an organophosphate (OP) pesticide used to combat sea lice infestations in farmed salmonids.
S4219 Azaperone Azaperone (NSC 170976) crosses the blood-brain barrier and binds to both DI and D2 receptors, being an antagonist of Dopamine receptors with sedative and antiemetic effects, which is used mainly as a tranquilizer in veterinary medicine.
S2106 Azasetron HCl Azasetron HCl (Y-25130) is a selective 5-HT3 receptor antagonist with IC50 of 0.33 nM used in the management of nausea and vomiting induced by cancer chemotherapy.
S3186 Azatadine dimaleate Azatadine (SCH10649) is an histamine and cholinergic inhibitor with IC50 of 6.5 nM and 10 nM, respectively.
S1721 Azathioprine Azathioprine is an immunosuppressive drug, inhibiting purine synthesis and GTP-binding protein Rac1 activation, used in the treatment of organ transplantation and autoimmune diseases.
S4978 Azathramycin Azathramycin (Azaerythromycin A, Azaerythromycin) is a macrolide antibiotic containing cladinose.
S0365 AZD-26 AZD-26 (AKT-IN-1) is an allosteric inhibitor of AKT with IC50 of 1.042 μM.
S8344 AZD-5153 6-hydroxy-2-naphthoic acid AZD-5153 6-hydroxy-2-naphthoic acid (HNT salt) is a potent, selective, and orally available BET/BRD4 bromodomain inhibitor with pKi of 8.3 for BRD4. AZD-5153 inhibits the expression of Nuclear receptor binding SET domain protein 3 (NSD3) target genes. NSD3, via H3K36me2, acts as an epigenetic deregulator to facilitate the expression of oncogenesis-promoting genes.
E0101 AZD-6280

AZD6280 is a novel γ-aminobutyric acid A type A(GABAA) receptor modulator with higher in vitro efficacy at the α2,3 subtypes as compared to the α1 and α5 subtypes.

S0164 AZD-7325 AZD7325 is a positive allosteric modulator (PAM) of α2,3 subtype-selective GABA receptor with pKi of 9.51 and has less efficacy at the α1 and α5 receptor subtypes. AZD7325 is a moderate CYP1A2 and a potent CYP3A4 inducer in vitro.
S8375 AZD0156 AZD0156 is a potent and selective inhibitors of ATM kinase, with potential chemo-/radio-sensitizing and antineoplastic activities. AZD0156 prevents DNA damage checkpoint activation, disrupts DNA damage repair, induces tumor cell apoptosis, and leads to cell death of ATM-overexpressing tumor cells.
S8708 AZD0364 (ATG-017) AZD0364 (ATG-017) is a pre-clinical ERK1/2 inhibitor with an IC50 of 0.6 nM for ERK2.
S7145 AZD1080 AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor, inhibits human GSK3α and GSK3β with Ki of 6.9 nM and 31 nM, respectively, shows >14-fold selectivity against CDK2, CDK5, CDK1 and Erk2.
S7104 AZD1208 AZD1208 is a potent, and orally available Pim kinase inhibitor with IC50 of 0.4 nM, 5 nM, and 1.9 nM for Pim1, Pim2, and Pim3 in cell-free assays, respectively. AZD1208 induces autophagy, cell cycle arrest and apoptosis. Phase 1.
S8680 AZD1390 AZD1390 is a first-in-class orally available and CNS penetrant ATM inhibitor with an IC50 of 0.78 nM in cells and >10,000-fold selectivity over closely related members of the PIKK family of enzymes and excellent selectivity across a broad panel of kinases.
S2162 AZD1480 AZD1480 is a novel ATP-competitive JAK2 inhibitor with IC50 of 0.26 nM in a cell-free assay, selectivity against JAK3 and Tyk2, and to a smaller extent against JAK1. Phase 1.
S7263 AZD1981 AZD1981 is a potent, selective CRTh2 (DP2) receptor antagonist with IC50 of 4 nM, showing >1000-fold selectivity over more than 340 other enzymes and receptors, including DP1. Phase 2.
S6555 AZD2098 AZD2098 is a potent and bioavailable CCR4 receptor antagonist with pIC50 of 7.8.
S7029 AZD2461 AZD2461 is a novel PARP inhibitor with low affinity for Pgp than Olaparib. Phase 1.
S7253 AZD2858 AZD2858 is a selective GSK-3 inhibitor with an IC50 of 68 nM, activating Wnt signaling, increases bone mass in rats.
S8780 AZD3229 AZD3229 is a potent, pan-Kit (c-Kit) mutant inhibitor with potent single digit nM growth inhibition against a diverse panel of mutant Kit (c-Kit) driven Ba/F3 cell lines (GI50=1-50 nM), with good margin to KDR-driven effects. It also inhibits PDGFR mutants (Tel-PDGFRα, Tel-PDGFRβ, V561D/D842V).
S7106 AZD3463 AZD3463 is a novel orally bioavailable ALK inhibitor with Ki of 0.75 nM, which also inhibits IGF1R with equivalent potency. AZD3463 suppresses cell viability by inducing both cell apoptosis and autophagy.
S7040 AZD3514 AZD3514 is a potent and oral androgen receptor downregulator with Ki of 2.2 μM and has ability of reducing AR protein expression.Phase 1.
S7731 AZD3839 AZD3839 is a potent and selective BACE1 inhibitor with Ki of 26.1 nM, about 14-fold selectivity over BACE2. Phase 1.
S7339 AZD3965 AZD3965 is a potent, selective and orally available monocarboxylate transporter 1 (MCT1) inhibitor with a binding affinity of 1.6 nM, 6-fold selective over MCT2. Phase 1.
S2801 AZD4547 AZD4547 (ABSK 091) is a novel selective FGFR inhibitor targeting FGFR1/2/3 with IC50 of 0.2 nM/2.5 nM/1.8 nM in cell-free assays, weaker activity against FGFR4, VEGFR2(KDR), and little activity observed against IGFR, CDK2, and p38. Phase 2/3.
S8719 AZD4573 AZD4573 is a potent inhibitor of CDK9 (IC50 of <0.004 μM) with fast-off binding kinetics (t1/2 = 16 min) and high selectivity versus other kinases, including other CDK family kinases.
S6645 AZD5069 AZD5069 is a novel antagonist of CXCR2, which is shown to inhibit binding of CXCL8 to CXCR2 with a pIC50 value of 8.8 and inhibit CXCL8 binding to CXCR1 with pIC50 values of 6.5.
S9875 AZD5305 AZD5305 is a highly selective and potent inhibitor of PARP1 with an IC50 of 3 nM in wild-type A549 lung cancer cells. AZD5305 shows no or minimal growth inhibitory effects in other cells (IC50s >10μM).
S2621 AZD5438 AZD5438 is a potent inhibitor of CDK1/2/9 with IC50 of 16 nM/6 nM/20 nM in cell-free assays. It is less potent to CDK5/6 and also inhibits GSK3β. Phase 1.
S8643 AZD5991 AZD5991 is a macrocyclic MCL-1 inhibitor with sub-nanomolar affinity for MCL-1 (Ki = 0.13 nM). The binding affinity of AZD5991 is about 25-fold lower for mouse Mcl-1 vs. human Mcl-1 but only four-fold lower for rat Mcl-1.
S1462 AZD6482 AZD6482 (KIN-193) is a PI3Kβ inhibitor with IC50 of 10 nM, 8-, 87- and 109-fold more selective to PI3Kβ than PI3Kδ, PI3Kα and PI3Kγ in cell-free assays. Phase 1.
S7517 AZD7545 AZD7545 is a potent PDHK inhibitor with IC50 of 36.8 nM and 6.4 nM for PDHK1 and PDHK2, respectively. It failed to inhibit PDHK4 at higher concentrations(>10 nM), AZD7545 stimulates PDHK4 activity.
S0448 AZD7594 AZD7594 (AZ13189620) is a potent selective nonsteroidal glucocorticoid receptor modulator with IC50 of 0.9 nM.
S8843 AZD7648 AZD7648 is a potent inhibitor of DNA-PK with an IC50 of 0.6 nM in biochemical assay and more than 100-fold selective against 396 other kinases.
S1532 AZD7762 AZD7762 is a potent and selective inhibitor of Chk1 with IC50 of 5 nM in a cell-free assay. It is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck. Phase 1.
S1555 AZD8055 AZD8055 is a novel ATP-competitive mTOR inhibitor with IC50 of 0.8 nM in MDA-MB-468 cells with excellent selectivity (∼1,000-fold) against PI3K isoforms and ATM/DNA-PK. AZD8055 induces caspase-dependent apoptosis and also induces autophagy. Phase 1.
S7694 AZD8186 AZD8186 is a potent and selective inhibitor of PI3Kβ and PI3Kδ with IC50 of 4 nM and 12 nM, respectively. Phase 1.
S2134 AZD8330 AZD8330 (ARRY704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.
S7966 AZD8835 AZD8835 ia a novel mixed inhibitor of PI3Kα and PI3Kδ with IC50 of 6.2 nM and 5.7 nM, respectively, also with selectivity against PI3Kβ (IC50=431 nM) and PI3Kγ (IC50=90 nM).
S8372 AZD9496 AZD9496 is an oral estrogen receptor inhibitor that blocks the growth of ER-positive and ESR1 mutant breast tumours in preclinical models.
S8958 AZD9833 AZD9833 is an orally available and selective estrogen receptor (ER) antagonist with antineoplastic activity.
E0319 AZD9977

AZD9977 is a potent, selective, and orally active mineralocorticoid receptor (MR) modulator.

S4550 Azelaic acid Azelaic acid (Nonanedioic acid, Finacea, Azelex, Anchoic acid) is an organic compound produced by the ozonolysis of oleic acid and possesses antibacterial, keratolytic, comedolytic, and anti-oxidant activity.
S2552 Azelastine HCl Azelastine HCl is a potent, second-generation, selective, histamine receptor antagonist, used in the treatment of rhinitis.
S6415 Azeliragon (TTP488) Azeliragon (TTP488, PF-04494700) is an orally bioavailable small molecule that inhibits the receptor for advanced glycation endproducts (RAGE), which is an immunoglobulin-like cell surface receptor overexpressed in brain tissues of patients with AD.
S3053 Azelnidipine Azelnidipine (UR-12592) is a dihydropyridine calcium channel blocker.
S7454 Azemiglitazone (MSDC-0602)

Azemiglitazone (MSDC-0602) is a direct mitochondrial pyruvate carrier (MPC) inhibitor that modulates central carbon metabolism in mice and humans.

S5572 Azetidine-2-carboxylic acid Azetidine-2-carboxylic acid (L-Aze) is a toxic and teratogenic non-protein amino acid that is misincorporated into protein in place of proline, altering collagen, keratin, hemoglobin, and protein folding.
S0675 Azide-PEG5-Tos Azide-PEG5-Tos (Azido-PEG5-OTs) is a cleavable 5-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S1551 Azido-PEG1-CH2CO2H Azido-PEG1-CH2CO2H is a PROTAC linker, which refers to the alkyl/ether composition. Azido-PEG1-CH2CO2H is applicable to the synthesis of PROTAC BRD4 Degrader-1.
S1938 Azido-PEG2-C2-acid Azido-PEG2-C2-acid is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S0616 Azido-PEG2-C2-amine Azido-PEG2-C2-amine (N3-PEG2-CH2CH2NH2) is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. Azido-PEG2-C2-amine is a non-cleavable 2-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S1388 Azido-PEG2-CH2COOH Azido-PEG2-CH2COOH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1418 Azido-PEG3-alcohol Azido-PEG3-alcohol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1861 Azido-PEG3-C-Boc Azido-PEG3-C-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1670 Azido-PEG4-Boc Azido-PEG4-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S0605 Azido-PEG4-CH2-Boc Azido-PEG4-CH2-Boc is a cleavable 4-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). Azido-PEG4-CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be applied into the synthesis of PROTACs.
S1746 Azido-PEG5-amine Azido-PEG5-amine is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1877 Azido-PEG5-Boc Azido-PEG5-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S0642 Azido-PEG6-amine Azido-PEG6-amine is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. Azido-PEG6-amine is also a non-cleavable 6-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0594 Azido-PEG7-amine Azido-PEG7-amine is a non-cleavable 7-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S1447 Azido-PEG8-amine Azido-PEG8-amine is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S0656 Azido-PEG9-acid Azido-PEG9-acid is a non-cleavable 9-unit PEG ADC linker applied in the synthesis of antibody-drug conjugates (ADCs).
S3046 Azilsartan Azilsartan (TAK-536) is an angiotensin II type 1 (AT1) receptor antagonist with IC50 of 2.6 nM.
S3057 Azilsartan Medoxomil Azilsartan Medoxomil (TAK-491) is a potent angiotensin II type 1 (AT1) receptor antagonist, inhibits the RAAS, with an IC50 of 2.6 nM, exhibits >10,000-fold selectivity over AT2.
S1835 Azithromycin (CP-62993) Azithromycin (CP-62993, XZ-450) is an antibiotic by inhibiting protein synthesis, used for the treatment of bacterial infections.
S4147 Azithromycin Dihydrate Azithromycin Dihydrate is an acid stable orally administered macrolide antimicrobial drug, structurally related to erythromycin.
S3195 Azlocillin sodium salt Azlocillin is an acylampicillin with a broad spectrum against bacteria.
S6033 Azo Rubine Azo Rubine is an synthetic red food dye and is used for the purposes where food is heat-treated after fermentation.
S2430 Azodicarbonamide Azodicarbonamide is the first known nucleocapsid inhibitor that inhibits HIV-1 and a broad range of retroviruses by targeting the nucleocapsid CCHC domains. Azodicarbonamide inhibits the HIV-1RF-induced cytopathicity of CEM-SS cells with an EC50 of 38 µM in a standard cell-based antiviral assay .
S2267 Azomycin Azomycin (2-Nitroimidazole) is an antimicrobial antibiotic produced by a strain of Nocardia mesenterica.
S8304 Azoramide Azoramide is a small-molecule modulator of the unfolded protein response (UPR). It improves ER protein-folding ability and activates ER chaperone capacity to protect cells against ER stress.
S1505 Aztreonam Aztreonam (SQ 26776) is a synthetic monocyclic beta-lactam antibiotic, used to treat Gram-negative aerobic bacteria infection.
S3191 Azumolene Azumolene (EU4093 free base), an equipotent dantrolene analog, is a ryanodine receptor (RyR) modulator that inhibits the calcium-release.
S5526 β-Alanine β-Alanine (beta-Alanine, 3-Aminopropanoic acid) is a naturally occurring beta amino acid formed in vivo by the degradation of dihydrouracil and carnosine. It acts as a neurotransmitter by activating glycine and GABA receptors.
S6219 β-Alanine methyl ester hydrochloride β-Alanine ethyl ester is the ethyl ester of the non-essential amino acid β-alanine.