Almonertinib (HS-10296)

Catalog No.S8817 Synonyms: Aumolertinib, Ameile

For research use only.

Almonertinib (Aumolertinib, HS-10296, Ameile) is a small molecule inhibitor of EGFR-activating mutations and T790M-resistant mutation with limited activity against wild-type EGFR.

Almonertinib (HS-10296) Chemical Structure

CAS No. 1899921-05-1

Selleck's Almonertinib (HS-10296) has been cited by 1 Publication

Purity & Quality Control

Choose Selective EGFR Inhibitors

Other EGFR Products

Biological Activity

Description Almonertinib (Aumolertinib, HS-10296, Ameile) is a small molecule inhibitor of EGFR-activating mutations and T790M-resistant mutation with limited activity against wild-type EGFR.
Targets
EGFR-sensitizing mutation [1] EGFR-T790M resistance mutation [1]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 525.64
Formula

C30H35N7O2

CAS No. 1899921-05-1
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=NC=CC(=N2)C3=CN(C4=CC=CC=C43)C5CC5)OC

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04841811 Not yet recruiting Drug: Almonertinib Lung Cancer Guangdong Association of Clinical Trials|Jiangsu Hansoh Pharmaceutical Co. Ltd. August 15 2021 Phase 2
NCT04882345 Not yet recruiting Drug: Almonertinib Lung Cancer|EGFR Gene Mutation Shanghai Chest Hospital|Jiangsu Hansoh Pharmaceutical Co. Ltd. July 15 2021 Phase 2
NCT04944069 Not yet recruiting Drug: Almonertinib|Drug: Bevacizumab NSCLC|Leptomeningeal Metastasis|EGFR Activating Mutation Second Affiliated Hospital of Nanchang University|Jiangsu Hansoh Pharmaceutical Co. Ltd. July 2021 Not Applicable
NCT04870190 Not yet recruiting Drug: Almonertinib|Drug: Osimertinib NSCLC Shanghai Chest Hospital June 1 2021 Phase 3
NCT04687241 Not yet recruiting Drug: Almonertinib|Drug: Placebo Almonertinib Non-small Cell Lung Cancer Jiangsu Hansoh Pharmaceutical Co. Ltd. January 18 2021 Phase 3

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Almonertinib (HS-10296) | Almonertinib (HS-10296) supplier | purchase Almonertinib (HS-10296) | Almonertinib (HS-10296) cost | Almonertinib (HS-10296) manufacturer | order Almonertinib (HS-10296) | Almonertinib (HS-10296) distributor