All Products

Catalog No. Product Name Information
S6049 (+)-(S)-Carvone (+)-(S)-Carvone, a monoterpene found mainly in caraway and dill seed oils, is used in cosmetic, food and pharmaceutical preparations.
S4628 (+/-)-Sulfinpyrazone Sulfinpyrazone (G-28315, NSC 75925) is one of the most studied platelet COX inhibitors, also a uricosuric agent that competitively inhibits uric acid reabsorption in kidney proximal tubules.
S0043 (-)-(S)-B-973B (-)-(S)-B-973B (B 973B, CS-2844) is a potent allosteric agonist with antinociceptive activity. (-)-(S)-B-973B is a positive allosteric modulator of α7 nAChR,.
E2706 (-)-Secoisolariciresinol

(-)-Secoisolariciresinol is a lignan, a type of phenylpropanoids.

S5556 (-)-Sparteine Sulfate Sparteine Sulfate, a quinolizidine alkaloid, is the sulfate form of sparteini, which is a sodium channel blocker used as an oxytocic and an anti-arrhythmia agent.
E0915 (-)-Syringaresinol

(-)-Syringaresinol suppresses LPS-induced microglia activation via downregulation of NF-κB p65 signaling and interaction with ERβ.

E0549 (-)-Syringaresinol 4-O-β-D-glucopyranoside

(-)-Syringaresinol 4-O-β-D-glucopyranoside, isolated from <i>Alhagi sparsifolia Shap</i>, is a natural potential neuroinflammatory inhibitor.

E2154 (1S)-(-)-Camphanic acid
S5596 (1S)-(-)-α-Pinene α-Pinene is found in the oils of many species of many coniferous trees, notably the pine and has insecticidal activity. (1S)-(-)-α-Pinene is a monoterpene and shows sleep enhancing property through a direct binding to GABAA-benzodiazepine (BZD) receptors by acting as a partial modulator at the BZD binding site.
S4746 (20S)-Protopanaxadiol 20(S)-Protopanaxadiol (PPD, 20-Epiprotopanaxadiol), the main intestinal metabolite of ginsenosides, is one of the active ingredients in ginseng. 20(S)-Protopanaxadiol inhibits P-glycoprotein in multidrug resistant cancer cells.
S3617 (20S)-Protopanaxatriol (20S)-Protopanaxatriol (g-PPT, 20(S)-APPT), a neuroprotective metabolite of ginsenoside, protopanaxatriol (g-PPT), is a functional ligand for both GR and ERbeta and could modulate endothelial cell functions through the glucocorticoid receptor (GR) and estrogen receptor (ER).
S9393 (4S)-4-Hydroxy-L-isoleucine (4S)-4-hydroxy-L-isoleucine is an L-isoleucine derivative that is L-isoleucine bearing a (4S)-hydroxy substituent. It has a role as a plant metabolite.
S3365 (S)-(-)-1-Phenylethanol

(S)-(-)-1-Phenylethanol ((S)-1-Phenylethanol, (S)-(-)-Phenylethanol) is an enantiomer of 1-Phenylethanol with flavor properties.

S6055 (S)-(−)-Limonene (S)-(−)-Limonene, a fragrance monoterpene mainly found in citrus peel oil, is also naturally occurs in the essential oils of herbs, tea tree oil, and turpentine oil.
S6260 (S)-(−)-α-Methylbenzylamine (S)-(−)-α-Methylbenzylamine is a chiral auxiliary in the enantiodivergent synthesis of simple isoquinoline alkaloids.
S2423 (S)-10-Hydroxycamptothecin (S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor with potent anti-tumor activity.
S6271 (S)-2-Hydroxy-3-phenylpropanoic acid (S)-2-Hydroxy-3-phenylpropanoic acid (L-(-)-3-Phenyllactic acid, (2S)-2-Hydroxy-3-phenylpropanoic acid) is a valuable building block in the pharmaceutical and chemical industry—has recently emerged as an important monomer in the composition of the novel degradable biocompatible material of polyphenyllactic acid.
S6292 (S)-2-Hydroxysuccinic acid (S)-2-Hydroxysuccinic acid (L-Malic acid), is a naturally occurring isomer of malic acid, found mainly in sour and unripe fruits.
E0741 (S)-4-(8-Amino-3-(pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide (S)-4-(8-Amino-3-(pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl) benzamide is an intermediate in the preparation process of Acalabrutinib.
S7505 (S)-crizotinib (S)-crizotinib, the (S)-enantiomer of crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM in a cell-free assay.
S6266 (S)-Glutamic acid (S)-Glutamic acid (L-Glutamic acid) is an endogenous, non-selective glutamate receptor agonist.
S6046 (S)-Leucic acid Leucic acid ((S)-α-hydroxyisocaproic acid) is a metabolite of the branched chain amino acid known as leucine, which plays a significant role in the synthesis of muscle protein.
E0360 (S)-Methoprene (S)-Methoprene is a juvenile hormone analogue that prohibits the ability of the insect to change from pupae to adult.
S3631 (S)-Methylisothiourea sulfate (S)-Methylisothiourea sulfate is a potent inhibitor of inducible NO synthase (iNOS).
S0895 (S)-Viloxazine Hydrochloride (S)-Viloxazine Hydrochloride is the S-isomer of Viloxazine, a selective norepinephrine reuptake inhibitor (NRI) that can be used as an antidepressant.
S0097 (S,R,S)-AHPC (MDK7526) (S,R,S)-AHPC (MDK7526, VH032-NH2, VHL ligand 1) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC is potential useful for the targeted degradation of the androgen receptor. (S,R,S)-AHPC can be connected to the ligand for protein such as BCR-ABL1 by a linker to form PROTACs such as GMB-475. GMB-475 induces the degradation of BCR-ABL1 with IC50 of 1.11 μM in Ba/F3 cells.
S1062 (S,R,S)-AHPC hydrochloride (S,R,S)-AHPC hydrochloride (VH032-NH2, VHL ligand 1) is the VH032-based VHL ligand that is applicable to the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC hydrochloride can be connected to the ligand for protein by a linker to form PROTACs.
S3502 (S,R,S)-AHPC-PEG4-NH2 hydrochloride (S,R,S)-AHPC-PEG4-NH2 hydrochloride (VH032-PEG4-NH2 hydrochloride, VHL Ligand-Linker Conjugates 4 hydrochloride, E3 ligase Ligand-Linker Conjugates 7) is a PROTAC E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker.
E2324 10-Shogaol 10-Shogaol is an antioxidant from Zingiber officinale for human skin cell growth and a migration enhancer. [10]-Shogaol inhibits COX-2 with an IC50 of 7.5 μM and has antiproliferation activity.
S9129 20(S)-Ginsenoside Rh1 20(S)-Ginsenoside Rh1 (Prosapogenin A2, Sanchinoside B2, Sanchinoside Rh1) is one of major bioactive compounds extracted from red ginseng, which has been increasingly used for enhancing cognition and physical health worldwide. It exhibits potent characteristics of anti-inflammatory, antioxidant, immunomodulatory effects, and positive effects on the nervous system. Ginsenoside Rh1 inhibits the expression of PPAR-γ, TNF-α, IL-6, and IL-1β.
E0499 4SC-203 4SC-203 (SC71710) is a multikinase inhibitor with potential antineoplastic activity. 4SC-203 selectively inhibits FMS-related tyrosine kinase 3 (FLT3/STK1), FLT3 mutated forms, and vascular endothelial growth factor receptors (VEGFRs).
S9043 6-Shogaol 6-Shogaol, a naturally occuring product found in ginger, has anti-inflammatory and anticancer properties.
E2325 8-Shogaol 8-Shogaol, one of the pungent phenolic compounds in ginger, exhibits anti-platelet activity (IC50=5 μM) and inhibits COX-2 (IC50=17.5 μM). [8]-Shogaol induces apoptosis in human leukemia cells.
S8598 S 38093 S 38093 is a histamine H3 antagonist/inverse agonist with a moderate affinity for rat, mouse and human H3 receptors (Ki = 8.8, 1.44 and 1.2 μM, respectively) and no affinity for other histaminergic receptors.
S5448 S(-)-Carbidopa S(-)-Carbidopa is a peripheral decarboxylase inhibitor, used in combination with levodopa for treatment of Parkinsonism.
S5981 S(-)-Propranolol hydrochloride (S)-(-)-Propranolol hydrochloride, the active enantiomer of propranolol, is a β-Adrenoceptor (β-Adrenergic Receptor) antagonist with log Kd values of -8.16, -9.08, and -6.93 for β1, β2, and β3, respectively.
S5192 S-(+)-Ketoprofen S-(+)-Ketoprofen (Compound 1, Actron, (S)-Ketoprofen, Dexketoprofen) is a potent inhibitor of cyclooxygenase (COX) with IC50 of 1.9 nM and 27 nM for COX-1 and COX-2, respectively.
S2127 S-(+)-Rolipram S-(+)-Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and anti-depressant activity in the central nervous system, less potent than its R enantiomer.
S9339 S-(-)-Cotinine S-(-)-Cotinine, a constituent of tobacco products and the major metabolite of nicotine, stimulates nicotinic receptors to evoke the release of DA in a calcium-dependent manner from superfused rat striatal slices.
S0838 S-(4-Nitrobenzyl)-6-thioinosine (NBMPR) S-(4-Nitrobenzyl)-6-thioinosine (NBMPR, Nitrobenzylthioinosine, NBTI, NSC 296962) is an inhibitor of ENT1 transporter that crosses the blood-brain barrier and is able to potentiate the neuroprotective effects of adenosine.
E1131 S-217622 S-217622 (Ensitrelvir fumarate) is the first orally active non-covalent, non-peptidic, SARS-CoV-2 3CL protease inhibitor with IC50 of 13 nM.
S7868 S-Adenosyl-L-homocysteine (SAH) S-Adenosyl-L-homocysteine (SAH, S-Adenosylhomocysteine, AdoHcy, Formycinylhomocysteine) is an inhibitor for (Methyltransferase Like 3-14) METTL3-METTL14 heterodimer complex (METTL3-14) with IC50 of 0.9 μM.
S4791 S-allyl-L-cysteine S-Allyl cysteine (SAC, S-Allylcysteine), a natural constituent of fresh garlic, has antioxidant and anticancer properties in animals. S-Allyl cysteine has an anticancer effect through the induction of apoptosis and a cell cycle arrest.
S0096 S-Gboxin S-Gboxin, a functional analogue of Gboxin, is an oxidative phosphorylation (OXPHOS) inhibitor which inhibits growth of mouse and human glioblastoma (GBM) with IC50 of 470 nM.
S4786 S-Methyl-L-cysteine S-Methyl-L-cysteine (S-Methylcysteine) is one of the identified number of bioactive substances in garlic that are water soluble that may exert some chemopreventive effects on chemical carcinogenesis.
S2902 S-Ruxolitinib (INCB018424) S-Ruxolitinib is the chirality of INCB018424, which is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3. Phase 3.
S6712 S107 S107 is a Type 1 ryanodine receptor (RyR1) stabilizer that binds RyR1 and enhances the binding affinity of calstabin-1.
S0713 S107 hydrochloride S107 hydrochloride is a specific stabilizer of RyR2 (type 2 ryanodine receptor)/FKBP12.6 (FK506 binding protein 12.6) complex that affects Ca2+ signaling.
E0326 S18-000003 S18-000003, a potent, selective and orally active inhibitor of retinoic acid receptor-related orphan receptor-gamma-t (RORγt), with an IC50 of <30 μM towards human RORγt in competitive binding assays.
S6754 S1RA S1RA (E-52862) is a selective sigma-1 receptor (σ1R) antagonist with a reported binding affinity of Ki = 17.0 ± 7.0 nM for human σ1 receptor , selective over the sigma-2 receptor and against a panel of other 170 receptors, enzymes, transporters and ion channels.
S1155 S3I-201 S3I-201 (NSC 74859) shows potent inhibition of STAT3 DNA-binding activity with IC50 of 86 μM in cell-free assays, and low activity towards STAT1 and STAT5.
S8404 S49076 S49076 is a novel, potent inhibitor of Met (c-Met), AXL/MER, and FGFR1/2/3 with IC50 values below 20 nmol/L.
S8759 S55746 S55746 (S 055746,BCL201) is a novel, orally active BCL-2 specific inhibitor (Ki = 1.3 nM) with poor affinity for BCL-XL and no significant binding to MCL-1, BFL-1 (BCL2A1/A1). The selectivity of S55746 for BCL-2 versus BCL-XL ranges from ~70 to 400 folds.
S8383 S63845 S63845 is a new, selective MCL-1 inhibitor with the Kd value of 0.19 nM and has no discernible binding to the other BCL-2 members, BCL-2 or BCL-XL.
S8836 S64315 (MIK665) S64315 (MIK665) is an inhibitor of induced myeloid leukemia cell differentiation protein Mcl-1 with Ki value of 1.2 nM and has potential pro-apoptotic and antineoplastic activities.
S0385 S6K-18 S6K-18 is a highly selective inhibitor of ribosomal protein S6 kinase beta-1 (S6K1, p70S6K, p70-S6K).
S6922 S961 S961 is a biosynthetic insulin receptor antagonist that inhibits cellular proliferation and colony formation in breast tumour cells.
A2037 Sabatolimab (anti-TIM-3)

Sabatolimab (anti-TIM-3) (MBG453, NVP-MBG453) is a high-affinity, humanized IgG4 antibody targeting TIM-3 on the surface of T-cells.

S8061 Sabutoclax Sabutoclax (BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively.
S4819 Saccharin Saccharin (Benzoic sulfimide, O-Sulfobenzimide, O-Benzoic sulfimide, Saccharimide) is an artificial sweetener with effectively no food energy.
S8326 Saccharin 1-methylimidazole (SMI) Saccharin 1-methylimidazole (SMI) is considered a general-purpose activator for DNA and RNA synthesis.
S6052 Saccharin sodium salt hydrate Saccharin (O-Sulfobenzimide, O-Benzoic sulfimide, Saccharimide) is an artificial sweetener with effectively no food energy.
A2031 Sacituzumab (anti-Trop-2) Sacituzumab (anti-Trop-2) is a fully humanized IgG1 kappa monoclonal antibody that binds Trop-2.
E2841 Sacituzumab govitecan Sacituzumab govitecan (IMMU-132) is an antibody-drug conjugate (ADC) targeting Trop-2 for delivery of SN-38, showing anticancer activity.
S4426 Sacubitril hemicalcium salt Sacubitril (AHU-377) hemicalcium salt, a component of the heart failure medicine LCZ696, is a potent inhibitor of neprilysin (neutral endopeptidase, NEP).
S7678 Sacubitril/valsartan (LCZ696) Sacubitril/valsartan (LCZ696, Sacubitril, Valsartan), consisting of valsartan and sacubitril in 1:1 molar ratio, is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and heart failure. Phase 3.
S3388 Sacubitrilat Sacubitrilat (Sac, LBQ-657) is an active inhibitor of neprilysin (NEP).
E3284 Safflower Extract
S5110 Safflower Yellow Safflower Yellow (Safflor Yellow, SY), the main active constituent of the traditional Chinese medicine Safflower, is known as a neuroprotective agent that indirectly attenuates neuroinflammation.
S5357 Safinamide Safinamide (EMD-1195686, PNU-15774E) is an orally active, selective, reversible monoamine oxidase-B inhibitor with both dopaminergic and non-dopaminergic (glutamatergic) properties. The IC50 value of safinamide for MAO-B is 98 nM.
S1472 Safinamide Mesylate Safinamide Mesylate (PNU-151774E, FCE28073) is mesylate salt of Safinamide, selectively and reversibly inhibits MAO-B with IC50 of 98 nM, exhibits 5918-fold selectivity against MAO-A. Phase 3.
E2130 Saikogenin A

Saikogenin A, isolated from a Chinese herbal plant called Tsai-Fu, is a dipeptidyl peptidase-IV (DPP-IV) inhibitor.

E0984 SAIKOGENIN D Saikogenin D is isolated from Bupleurum chinense. Saikogenin D activates epoxygenases that converts arachidonic acid to epoxyeicosanoids and dihydroxyeicosatrienoic acids.
E2272 Saikogenin F Saikogenin F, a genuine sapogenin isolated from Bupleurum falcatum L., exhibits anti-cancer activity.
S5466 Saikosaponin A Saikosaponin A is a triterpene saponin derived from the medicinal plant, Bupleurum chinensis DC. (Umbelliferae). It has a variety of pharmacological benefits, including anti-inflammatory, immunomodulatory, and anti-bacterial activities.
E0980 Saikosaponin B1 Saikosaponin B1 is a bioactive constituent of Radix Bupleuri with anticancer activity. Saikosaponin B1 significantly inhibits tumor growth in Medulloblastoma (MB) model by inhibiting the Hedgehog pathway through targeting Smoothened (SMO).
S9303 Saikosaponin B2 Saikosaponin B2 is a naturally occurring terpenoid that efficiently inhibits hepatitis C virus entry.
E0927 Saikosaponin B3

Saikosaponin B3 is a bioactive phytochemical of Bupleurum marginatum and B. falcatum and has anticancer and anti-oxidative activities. Saikosaponin b3 protects against MPTP-induced Parkinson's disease by preventing mitochondrial oxidative damage.

E0928 Saikosaponin B4

Saikosaponin B4 is a member of saikosaponins isolated from the roots of B. falcatum, selectively inhibits ACTH-induced lipolysis.

S9278 Saikosaponin C Saikosaponin C is a triterpene saponin found in Bupleurum that exhibits antiviral and pro-angiogenic activities.
S5454 Saikosaponin D Saikosaponin D, a calcium mobilizing agent (SERCA inhibitor), is a type of Saponin derivative, which is a component extracted from Bupleurum falactum. Saikosaponin D has anti-cancer activities.
E2255 Saikosaponin E

Saikosaponin E is a saikosaponin isolated from <i>Bupleurum yinchowense</i>.

E0921 Saikosaponin F Saikosaponin F is isolated from the root of Bupleururn kaoi and has the immunomodulatory effect.
E0983 Saikosaponin G

Saikosaponin G is a triterpene glycoside isolated from Bupleuri Radix.

E0981 Saikosaponin H Saikosaponin H is a saikosaponin derived from the herb Radix bupleuri .
E0982 Saikosaponin I Saikosides I is an active Saikosaponin component in Bupleurum, with a effect of promoting secretion.
P1166 Sakamototide substrate peptide (TFA) Sakamototide substrate peptide TFA is a peptide substrate for members of the AMPK family of kinases, used in kinase activity assays.
S0938 Sakuranetin Sakuranetin belongs to the group of methoxylated flavanones, with a widely bioactivity of antiproliferative against human cell lines typical for B16BL6 melanoma, esophageal squamous cell carcinoma (ESCC) and colon cancer (Colo 320), antiviral activity towards human rhinovirus 3 and influenza B virus, antioxidant, antimicrobial, antiinflammatory, antiparasitic, antimutagenic, and antiallergic properties.
S5494 Salbutamol Salbutamol (Albuterol) is a short-acting, selective beta2-adrenergic receptor agonist used to treat or prevent bronchospasm in patients with asthma, bronchitis, emphysema, and other lung diseases.
S2507 Salbutamol Sulfate Salbutamol Sulfate (Albuterol) is a short-acting β2-adrenergic receptor agonist with an IC50 of 8.93 µM.
S2351 Salicin Salicin (Salicoside, Salicine) is a phenol β-glycosid produced from willow bark that shows anti-inflammatory effects. It is a natural, non-selective COX-1 and COX-2 inhibitor.
S6404 Salicylamide Salicylamide (o-hydroxybenzamide) is a non-prescription drug with analgesic and antipyretic properties.
S4187 Salicylanilide Salicylanilides (WR10019) are a group of compounds with a wide range of biological activities including antiviral potency, antibacterial (including antimycobacterial) and antifungal activities.
S4539 Salicylic acid Salicylic acid (2-Hydroxybenzoic acid) is a beta hydroxy acid that occurs as a natural compound in plants which is an inhibitor of ethylene biosynthesis and cyclooxygenase activity.
S2396 Salidroside Salidroside (Rhodioloside), a phenylpropanoid glycoside isolated from Rhodiola rosea, has been reported to have a broad spectrum of pharmacological properties. Salidroside is a prolyl endopeptidase inhibitor. Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling. Salidroside protects dopaminergic neurons by enhancing PINK1/Parkin-mediated mitophagy.
S6451 Salifungin Salifungin (Multifungin, Bromosalicylchloranilide) is an antifungal and may cause allergic contact dermatitis in some individuals.
S8129 Salinomycin (from Streptomyces albus) Salinomycin (Coxistac, Bio-cox, Procoxacin), traditionally used as an anti-coccidial drug, has recently been shown to possess anti-cancer and anti-cancer stem cell (CSC) effects.
S7504 Salinosporamide A (NPI-0052) Salinosporamide A (NPI-0052, ML858, Marizomib, MRZ) is a novel marine derived proteasome inhibitor which inhibits CT-L β5, C-L β1, and T-L β2 proteasome activities in human erythrocyte-derived 20S proteasomes with IC50 of 3.5 nM, 430 nM, 28 nM.
S7684 Salirasib Salirasib (Farnesylthiosalicylic acid, FTS) is a potent competitive prenylated protein methyltransferase (PPMTase) inhibitor with Ki of 2.6 μM, which inhibits Ras methylation. Salirasib exerts antitumor effects and induces autophagy. Phase 2.
E3025 Salix Alba Bark Extract
S5527 Salmeterol Salmeterol (Astmerole, GR-33343X, SN408D) is a long-acting beta2-adrenergic receptor agonist with Ki value of 1.5 nM for WT β2AR and shows very high selectivity for the WT β2AR(β1Ki/β2Ki ratio of approximately 1500).
S4296 Salmeterol Xinafoate Salmeterol Xinafoate is a long-acting β2-adrenergic receptor agonist with anti-inflammatory effects, used in the treatment of asthma symptoms and chronic obstructive pulmonary disease (COPD) symptoms.
S2923 Salubrinal Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM in a cell-free assay.
E3641 Salvia Chinensis Benth Extract
E3657 Salvia japonica Extract
E3135 Salvia Miltiorrhiza Extract
S9055 Salvianolic acid A Salvianolic acid A (Dan Phenolic Acid A), a water-soluble compound extracted from Radix Salvia miltiorrhiza (Danshen), is an antioxidant and free radical scavenging compound that also acts as an inhibitor of the protein-protein interaction mediated by SH2 domains of Src-family kinases Src and Lck.
S4735 Salvianolic acid B Salvianolic acid B (Sal B, Lithospermate B, Lithospermic acid B), an antioxidant and free radical scavenging compound, is the most abundant bioactive compound extracted from the root of Salvia miltiorrhiza Bunge.
S0922 Salvianolic acid C Salvianolic acid C is a moderate mixed, noncompetitive inhibitor of Cytochrome P4502C8 (CYP2C8) and Cytochrome P45022J2 (CYP2J2) with Ki of 4.82 μM and 5.75 μM for CYP2C8 and CYP2J2, respectively.
E2540 Salvianolic acid F Salvianolic acid F is a kind of salvianolic acids, which are the most effective and abundant compounds extracted from Salvia miltiorrhiza with good anti-oxidative activity.
E2552 Salvigenin

Salvigenin, a natural polyphenolic compound, possesses neuroprotective effect, antitumor cytotoxic and immunomodulatory properties.

E0952 Samatasvir

Samatasvir is a highly effective and selective inhibitor on HCV NS5A, which can effectively inhibit HCV genotypes 1-5 replicatiors.

E3790 Sambucus Adnata Extract
S8322 Samotolisib (LY3023414) Samotolisib (LY3023414, GTPL8918) is an oral ATP competitive inhibitor of the class I PI3K isoforms, mTOR and DNA-PK.
S8722 Samuraciclib hydrochloride (ICEC0942 hydrochloride) Samuraciclib hydrochloride (ICEC0942 hydrochloride, CT7001 hydrochloride) is a new, orally bioavailable CDK7 inhibitor with an IC50 of 40nM. The IC50 values for CDK1, CDK2, CDK5 and CDK9 were 45-, 15-, 230- and 30-fold higher. ICEC0942 (CT7001) promotes cell cycle arrest and apoptosis.
S5859 Sancycline Sancycline (Bonomycin, Norcycline, GS 2147) is a semi-synthetic tetracycline antibiotic.
E2418 Sanggenone D Sanggenon D is a Diels-Alder-type adduct from Chinese crude drug root bark of Morus cathayana. Sanggenon D possesses antioxidant activity and inhibits Pancreatic lipase (PL) with the IC50 of 0.77 μM.
S9032 Sanguinarine Sanguinarine (Pseudochelerythrine, Sanguinarin, Sanguinarium), a benzophenanthridine alkaloid known as an anti-inflammatory agent, is a potent inhibitor of NF-κB activation.
S5452 Sanguinarine chloride Sanguinarine, a plant alkaloid, is a potent and specific protein phosphatase (PP) 2C inhibitor. Sanguinarine chloride can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.
E3151 Sanguisorbae Radix Extract
E2265 Sanguisorbigenin

Sanguisorbigenin is a natural antibacterial agent that inhibits methicillin-resistant <i>S. aureus</i> (MRSA).

S9225 Santalol Santalol is a naturally occuring sesquiterpene that has antibacterial, anti-hyperglycaemic, anti inflammatory and antioxidant effects.
E3683 Santalum album Extract
S2811 Sapanisertib (MLN0128) Sapanisertib (MLN0128, INK 128, TAK-228) is a potent and selective mTOR inhibitor with IC50 of 1 nM in cell-free assays; >200-fold less potent to class I PI3K isoforms, superior in blocking mTORC1/2 and sensitive to pro-invasion genes (vs Rapamycin). Phase 1.
E3725 Sapindus saponaria Linnaeus nutshell Extract (40%)
E3726 Sapindus saponaria Linnaeus nutshell Extract (70%)
S2192 Sapitinib (AZD8931) Sapitinib (AZD8931) is a reversible, ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 with IC50 of 4 nM, 3 nM and 4 nM in cell-free assays, more potent than Gefitinib or Lapatinib against NSCLC cell, 100-fold more selective for the ErbB family than MNK1 and Flt. Phase 2.
S2353 Sapogenins Glycosides Sapogenins glycosides (Saponins) are a mixture of triterpene and steroid saponins isolated from medicinal plants such as Aesculus hippocastanum L., Hedera helix L. and Ruscus aculeatus L., which are claimed to be effective for the treatment/prevention of venous insufficiency.
E0670 Saponaretin

Saponaretin (Isovitexin) is a flavonoid isolated from rice hulls of Oryza sativa and possesses anti-inflammatory and anti-oxidant activities; Isovitexin acts like a JNK1/2 inhibitor and inhibits the activation of NF-κB.

E3193 Saponaria Officinalis Extract
E3189 Saposhnikoviae Radix Extract
E0526 sappanone A Sappanone A, a homoisoflavanone isolated from the heartwood of Caesalpinia sappan (Leguminosae), induces HO-1 expression by activating Nrf2 through the p38 MAPK pathway, suppresses LPS-induced NF-κB activation by suppressing the phosphorylation of RelA/p65 at Ser536, exerting its anti-inflammatory effect.
S9568 Sapropterin Dihydrochloride Sapropterin Dihydrochloride (Tetrahydrobiopterin, R-THBP), a synthetic preparation of the dihydrochloride salt of naturally occurring tetrahydrobiopterin (BH4), is a phenylalanine hydroxylase activator.
S9625 Saquinavir (Ro 31-8959) Saquinavir (Ro 31-8959) is a potent and selective inhibitor of HIV proteinase with a mean IC50 of 2.7 nM in JM cells.
S7740 SAR-020106 SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor with an IC50 of 13.3 nM.
S0437 SAR-20347 SAR-20347 is a potent inhibitor of TYK2, JAK1, JAK2 and JAK3 with IC50 of 0.6 nM, 23 nM, 26 nM and 41 nM, respectively. SAR-20347 inhibits TYK2- and JAK1-mediated IL-12 and IFN-α signaling.
S7564 SAR125844 SAR125844 is a potent intravenously active and highly selective Met (c-Met) kinase inhibitor, displaying nanomolar activity against the wild-type kinase (IC50 value of 4.2 nmol/L) and H1094Y, Y1235D, M1250T, L1195V, and D1228H kinase domain mutants (IC50 values of 0.22, 1.7, 6.5, 65, and 81 nmol/L, respectively).
S2842 SAR131675 SAR131675 is a VEGFR3 inhibitor with IC50/Ki of 23 nM/12 nM in cell-free assays, about 50- and 10-fold more selective for VEGFR3 than VEGFR1/2, little activity against Akt1, CDKs, PLK1, EGFR, IGF-1R, c-Met, Flt2 etc.
S7682 SAR405 SAR405 is a low-molecular-mass kinase inhibitor of PIK3C3/Vps34 (KD 1.5 nM) showing high selectivity and not be active up to 10 μM on class I and class II PI3Ks as well as on mTOR. SAR405 prevents autophagy and synergizes with MTOR (mechanistic target of rapamycin) inhibition in tumor cells.
S4473 SAR405 R enantiomer SAR405 R enantiomer is the less active enantiomer of SAR405 which is an inhibitor of PIK3C3/Vps34.
E2385 SAR407899 hydrochloride SAR407899 hydrochloride is a selective, potent and ATP-competitive Rho kinase (ROCK) inhibitor, with an IC50 of 135 nM for ROCK-2, and Ki values of 36 and 41 nM for human and rat ROCK-2, respectively.
S6634 SAR7334 SAR7334 is a novel, highly potent and bioavailable inhibitor of TRPC6 channels.SAR7334 blocks TRPC6 currents with an IC50 of 7.9 nM in patch-clamp experiment.
S1006 Saracatinib (AZD0530) Saracatinib (AZD0530) is a potent Src inhibitor with IC50 of 2.7 nM in cell-free assays, and potent to c-Yes, Fyn, Lyn, Blk, Fgr and Lck; less active for Abl and EGFR (L858R and L861Q). Saracatinib induces autophagy. Phase 2/3.
S1977 Sarafloxacin HCl Sarafloxacin HCl (A-56620) is a hydrochloride salt form of sarafloxacin which is a quinolone antibiotic drug with IC50 of 0.96 μg/L.
P1150 Saralasin Acetate Saralasin Acetate, an octapeptide analog of angiotensin II, is a highly specific competitive inhibitor of angiotensin II that is used in the diagnosis of hypertension.
E3078 Sarcandra Glabra Extract
S4702 Sarcosine Sarcosine (N-methylglycine, Sarcosinic acid, Methylaminoacetic acid, Methylglycine) is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist.
E0604 Sari 59-801

SaRI 59-801 is an orally effective hypoglycemic compound. SaRI 59-801 decreases blood glucose in several species and to elevate plasma insulin in rats and mice.

A2011 Sarilumab (anti-IL-6Rα) Sarilumab (anti-IL-6Rα) is a fully human anti-IL-6Rα mAb that binds membrane-bound and soluble human IL-6Rα with high affinity, MW: 144.13 KD.
S9674 Saroglitazar Saroglitazar (Lipaglyn, ZYH1) is an agonist of peroxisome proliferator-activated receptor (PPAR) with EC50 of 0.65 pM and 3 nM for hPPARα and hPPARγ in HepG2 cells, respectively.
S3706 Sarpogrelate hydrochloride Sarpogrelate (MCI-9042) is a selective 5-HT2A antagonist with pKi values of 8.52, 7.43 and 6.57 for 5-HT2A, 5-HT2C and 5-HT2B receptors respectively.
E2172 Sarracenin
E3011 Sarsaparilla Extract
S3607 Sarsasapogenin Sarsasapogenin (SAR, Parigenin) is a steroidal sapogenin. It can provoke the generation of reactive oxygen species and activate unfolded protein response (UPR) signaling pathways. SAR potently inhibits NF-κB and MAPK activation, as well as IRAK1, TAK1, and IκBα phosphorylation in LPS-stimulated macrophages.
S4188 Sasapyrine Sasapyrine (Salsalate, NSC-49171) is a nonsteroidal oral anti-inflammatory agent.
E3789 Saussurea Involucrata Extract
S7674 Savolitinib (AZD6094) Savolitinib (Volitinib, AZD6094, HMPL-504) is a novel, potent, and selective MET inhibitor currently in clinical development in various indications, including PRCC. The IC50 values of this compound for c-Met and p-Met are 5 nM and 3 nM, respectively. It shows exquisite selectivity for c-Met over 274 kinase.
E3376 Saw palmetto Extract
S1540 Saxagliptin (BMS-477118) Saxagliptin (BMS-477118, Onglyza) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.
S4697 Saxagliptin hydrate Saxagliptin H2O (BMS-477118, Onglyza) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.
S2649 SB 200646 SB 200646 (SB 200646A) is a potent, selective and oral-active antagonist of 5-HT2B/2C over 5-HT2A receptor with 50 fold selectivity. The pKi for rat 5-HT2C receptor, rat 5-HT2B receptor and rat 5-HT2A receptor are 6.9, 7.5 and 5.2, respectively. SB 200646 has electrophysiological and anxiolytic properties in vivo.
S0387 SB 242235 SB-242235 is a potent and selective p38 MAP kinase inhibitor, inhibits p38 MAP kinase induced by IL-1β with an IC50 of approximately 1.0 μM in primary human chondrocytes.
S9516 SB 265610 SB265610, a competitive antagonist at the human CXCR2 receptor, can displace [125I]-IL-8 and [125I]-GROα with pIC50 values of 8.41 and 8.47 respectively, preventing receptor activation by binding to a region distinct from the agonist binding site.
S2856 SB 271046 hydrochloride SB 271046 hydrochloride is a potent, selective and orally active 5-HT6 receptor antagonist with pKi of 8.9, exhibits 200-fold greater selectivity over other 5-HT receptor subtypes.
S0523 SB 4 SB 4 is a potent and selective agonist of bone morphogenetic protein 4 (BMP4) signaling with EC50 of 74 nM. SB 4 enhances canonical BMP signaling and activates SMAD-1/5/9 phosphorylation.
S0893 SB-200646A SB-200646A is the first selective 5-HT2B/2C over 5-HT2A receptor antagonist with pKi values of 7.5, 6.9 and 5.2 for 5-HT2B, 5-HT2C and 5-HT2A, respectively. 
S0129 SB-297006 SB-297006 is an antagonist of C-C chemokine receptor 3 (CCR3) that suppresses antigen-induced accumulation of T(h)2 as well as eosinophils in the lungs. SB-297006 suppressed CCL11-induced Th2 chemotaxis with IC50 of 2.5 μM.
S7585 SB-334867 SB-334867 is a selective orexin-1 (OX1) receptor antagonist.
S7430 SB-3CT SB-3CT is an effective and selective gelatinase inhibitor with Ki of 13.9 nM and 600 nM for MMP-2 and MMP-9, respectively.
E0641 SB-649868

SB-649868 is a potent and selective orally active orexin (OX) 1 and OX2 receptor antagonist (pKi =9.4 and 9.5 at the OX1 and OX2 receptor, respectively).

S6741 SB-756050 SB-756050 is a selective TGR5 agonist (EC50 = 1.3 μM for the human receptor).
S1077 SB202190 (FHPI) SB202190 (FHPI) is a potent p38 MAPK inhibitor targeting p38α/β with IC50 of 50 nM/100 nM in cell-free assays, sometimes used instead of SB 203580 to investigate potential roles for SAPK2a/p38 in vivo. SB202190 inhibits endothelial cell apoptosis via induction of autophagy and heme oxygenase-1. SB202190 significantly suppresses Erastin‐dependent ferroptosis.
S1075 SB216763 SB216763 is a potent and selective GSK-3 inhibitor with IC50 of 34.3 nM for GSK-3α and equally effective at inhibiting human GSK-3β. SB216763 activates autophagy.
S7651 SB225002 SB225002 is a potent, and selective CXCR2 antagonist with IC50 of 22 nM for inhibiting interleukin IL-8 binding to CXCR2, > 150-fold selectivity over the other 7-TMRs tested.
S7741 SB239063 SB239063 is a potent and selective p38 MAPKα/β inhibitor with IC50 of 44 nM, showing no activity against the γ- and δ-kinase isoforms.
S2849 SB269970 HCl SB269970 HCl is a hydrochloride salt form of SB-269970, which is a 5-HT7 receptor antagonist with pKi of 8.3, exhibits >50-fold selectivity against other receptors.
S7540 SB273005 SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively.
S8931 SB290157 trifluoroacetate SB290157 trifluoroacetate (SB 290157 TFA) is a potent, competitive and selective antagonist of C3a receptor (C3aR) with IC50 of 200 nM for RBL-C3aR.
S8238 SB366791 SB-366791 is a novel, potent, and selective, cinnamide TRPV1 antagonist with an IC50 of 5.7 nM.
S2729 SB415286 SB415286 is a potent GSK3α inhibitor with IC50/Ki of 78 nM/31 nM with equally effective inhibition of GSK-3β. SB415286 causes MM cell growth arrest and apoptosis.
S1067 SB431542 SB431542 is a potent and selective inhibitor of ALK5 with IC50 of 94 nM in a cell-free assay, 100-fold more selective for ALK5 than p38 MAPK and other kinases.
S2186 SB505124 SB505124 is a selective inhibitor of TGFβR for ALK4, ALK5 with IC50 of 129 nM and 47 nM in cell-free assays, respectively, also inhibits ALK7, but does not inhibit ALK1, 2, 3, or 6.
S1476 SB525334 SB525334 is a potent and selective inhibitor of TGFβ receptor I (ALK5) with IC50 of 14.3 nM in a cell-free assay, 4-fold less potent to ALK4 than ALK5 and inactive to ALK2, 3, and 6.
S2220 SB590885 SB590885 is a potent B-Raf inhibitor with Ki of 0.16 nM in a cell-free assay, 11-fold greater selectivity for B-Raf over c-Raf, no inhibition to other human kinases.
S2773 SB705498 SB705498 is a TRPV1 antagonist for hTRPV1, antagonizes capsaicin, acid, and heat activation of TRPV1 with IC50 of 3 nM, 0.1 nM and 6 nM, shows a degree of voltage dependence, exhibits >100-fold selectivity for TRPV1 over TRPM8. Phase 2.
S2894 SB742457 SB742457 (GSK 742457) is a highly selective 5-HT6 receptor antagonist with pKi of 9.63, exhibits >100-fold selectivity over other receptors. Phase 2.
S2182 SB743921 HCl SB743921 is a kinesin spindle protein (KSP) inhibitor with Ki of 0.1 nM, almost no affinity to MKLP1, Kin2, Kif1A, Kif15, KHC, Kif4 and CENP-E. Phase 1/2.
S0118 SBC-110736 SBC-110736 is an inhibitor of proprotein convertase subtilisin kexin type 9 (PCSK9) that lowers cholesterol levels in mice.
S7976 SBC-115076 SBC-115076 is a potent extracellular proprotein convertase subtilisin kexin type 9 (PCSK9) antagonist.
S9957 SBFI-26

SBFI-26 competitively inhibits the activities of FABP5 and FABP7.

S7885 SBI-0206965 SBI-0206965 is a highly selective autophagy kinase ULK1 inhibitor with IC50 of 108 nM, about 7-fold selectivity over ULK2. SBI-0206965 inhibits autophagy and enhances apoptosis in human glioblastoma and lung cancer cells.
S8181 SBI-0640756 SBI-0640756 is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex. It can also suppress AKT and NF-kB signaling.
S6806 SBI-115 SBI-115 is a novel TGR5 (GPCR19) antagonist. SBI-115 decreases cell proliferation, cholangiocyte spheroid growth and cAMP levels in cystic cholangiocytes.
E1171 SBI-425 SBI-425, a potent, selective and oral bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor, effectively inhibits TNAP in the vasculature, improving cardiovascular parameters and survival.
S3187 SBI-477 SBI-477 is an insulin signaling inhibitor that deactivates the transcription factor MondoA, leading to reduced expression of the insulin pathway suppressors thioredoxin-interacting protein (TXNIP) and arrestin domain-containing 4 (ARRDC4). SBI-477 inhibits triacylglyceride (TAG) synthesis and enhances basal glucose uptake in human skeletal myocytes.
S2950 SBI-553 SBI-553 is a potent, brain-penetrant and allosteric modulator of NTR1 with EC50 of 0.34 μM.
S8980 SBI-797812 SBI-797812 is a NAMPT activator which is structurally similar to active-site directed NAMPT inhibitors and blocks binding of these inhibitors to NAMPT. SBI-797812 turns NAMPT into a "super catalyst" that more efficiently generates NMN.
E1065 SBP-3264 SBP-3264 is a valuable chemical probe for understanding the roles of STK3 and STK4 in acute myeloid leukemia (AML).
S3393 SBP-7455 SBP-7455 is a dual-Specific ULK1/2 autophagy inhibitor with IC50s of 13 nM and 476 nM for ULK1 and ULK2 in ADP-Glo assay, respectively.
S0762 SC 236 SC-236 is a potent, selective, orally active inhibitor of COX-2 with an IC50 of 10 nM and approximately 18,000-fold COX-2 selectivity.
S0986 SC-1 SC-1 (1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea, STAT3-IN-7), a Sorafenib analogue and potently inhibits the phosphorylation of STAT3, induces cell apoptosis through SHP-1 dependent STAT3 inactivation.
S0886 SC-26196 SC-26196 is a potent, orally active inhibitor of Delta6 desaturase (D6D) with IC50 of 0.2 µM in a rat liver microsomal assay. SC-26196 has anti-inflammatory properties.
S0445 SC-43 SC-43, a sorafenib derivative, is an agonist of Src-homology protein tyrosine phosphatase-1 (SHP-1/PTPN6) and reduces liver fibrosis. SC-43 reduces p-STAT3 and induces apoptosis with anti-tumor activity.
S4907 SC-514 SC-514 (GK 01140) is an orally active, ATP-competitive IKK-2 inhibitor with IC50 of 3-12 μM, blocks NF-κB-dependent gene expression, does not inhibit other IKK isoforms or other serine-threonine and tyrosine kinases.
S6686 SC-560 SC-560 is a highly selective COX-1 inhibitor with IC50 of 9 nM, compared with the IC50 of 6.3 μM for COX-2, nearly 1,000-fold higher than with COX-1.
S4468 SC-57461A SC-57461A is an inhibitor of leukotriene A4 hydrolase (LTA4H).
E0789 SC-58125 SC-58125 is a potent and selective inhibitor of human cyclooxygenase 2 (hCOX-2) and triple mutant of hCOX-2, with an IC50 of 0.04 μM and 1 µM, respectively.
S7124 SC144 SC144 is the first-in-class orally active small-molecule gp130 inhibitor that induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes.
S7273 SC75741 SC75741 is a potent NF-κB inhibitor with EC50 of 200 nM. SC75741 efficiently blocks influenza virus propagation.
S7863 SC79 SC79 is a brain-penetrable Akt phosphorylation activator and an inhibitor of Akt-PH domain translocation.
S1349 SC99 SC99 is an orally active, selective STAT3 inhibitor targeting JAK2-STAT3 pathway by docking into the ATP-binding pocket of JAK2, also inhibits phosphorylation of JAK2and STAT3 with no effects on the other kinases associated with STAT3 signaling.
E2015 Scabertopin

Scabertopin is a sesquiterpene lactone with potent anticancer activity.

S9358 Scarlet 808 Scarlet 808 is a chemical dye.
E3824 Scepteridium Ternatum Extract
S0476 SCH-23390 hydrochloride SCH-23390 hydrochloride (R-(+)-SCH-23390, SCH-23390) is a highly potent and selective dopamine D1-like receptor antagonist with Ki of 0.2 nM and 0.3 nM for the D1 and D5 dopamine receptor subtypes, respectively. SCH-23390 hydrochloride is a potent and high efficacy agonist at h5-HT2C receptors with Ki of 9.3 nM. SCH-23390 hydrochloride directly inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with IC50 of 268 nM.
S2945 SCH-442416 SCH-442416 is a selective antagonist of adenosine A2A receptor that binds to human and rat adenosine A2A receptors with Ki of 0.048 nM and 0.5 nM, respectively.
S8104 SCH58261 SCH 58261 is a potent and selective A2a adenosine receptor antagonist with Ki of 2.3 nM and 2 nM for rat A2a and bovine A2a, respectively.
S7101 SCH772984 SCH772984 is a novel, specific inhibitor of ERK1/2 with IC50 values of 4 nM and 1 nM in cell-free assay, respectively, And show robust efficacy in RAS- or BRAF-mutant cancer cells.
S9916 SCH79797 dihydrochloride SCH79797 dihydrochloride is a highly potent, selective nonpeptide protease activated receptor 1 (PAR1) antagonist, which can inhibit binding of a high-affinity thrombin receptor-activating peptide to PAR1 with an IC50 of 70 nM.
S9234 Schaftoside Schaftoside, a bioactive compound found in the Herba Desmodii Styracifolii, exhibits pancreatic lipase inhibitory activity. Schaftoside inhibits the expression of TLR4 and Myd88. Schaftoside also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission.
E2193 Schinifoline
E3734 Schisandrae Chinensis fructus Extract

Schisandrae Chinensis fructus Extract is extracted from Schisandra chinensis Fructus, the dry ripe fruit of <i>Schisandra chinensis</i> (Turcz.) Baill.. Schisandrae Chinensis fructus is mainly used for the treatment of dysphoria and palpitation, insomnia. Schisandrae Chinensis fructus and its active ingredients show a protective role in Neurological diseases, including cerebrovascular diseases, neurodegenerative diseases, or depression.

S3822 Schisandrin A Schisandrin A (Sch A, Deoxyschizandrin, Wuweizisu A) is an active component of Schisandrae Fructus with liver-protective, antitumor, and antioxidant activities. It is an agonist of the adiponectin receptor 2 (AdipoR2) with the IC50 value of 3.5 μM.
S3600 Schisandrin B (Sch B) Schisandrin B is the most abundant dibenzocyclooctadiene lignan present in the traditional Chinese medicinal herb Schisandra chinensis (Turcz.) Baill. It is a kind of ATR and P-gp inhibitor with high safety.
S9231 Schisanhenol Schisanhenol (Gomisin K3) is a compound derived from the fruit of a traditional Chinese herb Schisandra rubriflora, exhibiting strong inhibition toward UGT2B7.
S3880 Schisantherin A Schisantherin A (Gomisin C, Schisanwilsonin H, Arisanschinin K) is a dibenzocyclooctadiene that exhibits anti-tussive, sedative, anti-inflammatory, anti-osteoporotic, neuroprotective, cognition enhancing, and cardioprotective activities. Schisantherin A inhibits p65-NF-κB translocation into the nucleus by IκBα degradation.
S9443 Schisantherin B Schisantherin B (Gomisin-B, Wuweizi ester-B) is one bioactive of lignans isolated from Schisandra chinensis (Turcz.) Baill which has been commonly used as a traditional herbal medicine.
S3823 Schizandrol A Schizandrol A is one of the effective components in the dried fruit of Schizandra chinensis Bail and works by increasing dopamine, a neurotransmitter, in the brain.
S9126 Schizandrol B Schizandrol B (Gomisin A, Besigomsin, Wuweizi alcohol B, Gamma-Schisandrin), extracted from the fruit of Schisandra chinensis Baill., exhibits potent antitumor activities.
S0966 Sciadopitysin Sciadopitysi inhibits NF-κB activation and reduces the expression of c-Fos and NFATc1, thus inhibiting RANKL-induced osteoclastogenesis and bone loss. Sciadopitysin is a type of biflavonoids in leaves from ginkgo biloba.
S2354 Sclareol Sclareol, a labdane-type diterpene isolated from clary sage (Salvia sclarea), exerts growth inhibition and cytotoxic activity against a variety of human cancer cell lines.
S2355 Sclareolide Sclareolide (Norambreinolide) is a sesquiterpene lactone natural product derived from various plant sources including Salvia sclarea, Salvia yosgadensis, and cigar tobacco.
S3613 Scoparone Scoparone (6,7-dimethoxycoumarin, Aesculetin dimethyl ether, 6,7-Dimethylesculetin, Escoparone) is a natural organic compound discovered from Chinese herb Artemisia scoparia with anticoagulant, hypolipidemic, vasorelaxant, antioxidant, and anti-inflammatory actions.
S2545 Scopine Scopine is the metabolite of anisodine, which is a α1-adrenergic receptor agonist and used in the treatment of acute circulatory shock.
S9326 Scopolamine Scopolamine (Skopolamin) is a tropane alkaloid derived from plants of the nightshade family, specifically Hyoscyamus niger and Atropa belladonna, with anticholinergic, antiemetic and antivertigo properties.
S2508 Scopolamine (LSM-4015) HBr Scopolamine HBr (LSM-4015, NSC 61806) is a competitive muscarinic acetylcholine receptor antagonist with an IC50 of 55.3 nM.
S5873 Scopolamine HBr trihydrate Scopolamine HBr is a competitive muscarinic acetylcholine receptor antagonist with an IC50 of 55.3 nM.
S5699 Scopolamine N-Oxide HydrobroMide Monohydrate Scopolamine N-Oxide (Hyoscine N-oxide, Genoscopolamine) is a muscarinic antagonist used to study binding characteristics of muscarinic cholinergic receptors.
S3881 Scopoletin Scopoletin (Esculetin 6-methyl ether, Gelseminic acid, 6-Methylesculetin, Chrysatropic acid) is the main bioactive constituent of flower buds from Magnolia fargesii with anti-inflammatory, hypouricemic, and antioxidant activities.
S0951 Scopoletin acetate Scopoletin acetate is a coumarin isolated from the herbs of Atropa belladonna L.
S3262 Scopolin Scopolin, a coumarin isolated from Arabidopsis thaliana (Arabidopsis), attenuates hepatic steatosis through activation of SIRT1-mediated signaling cascades, a potent regulator of lipid homeostasis.
E2551 Scoulerin

Scoulerine (Discretamine), an isoquinoline alkaloid, is an inhibitor of BACE1 (ß-site amyloid precursor protein cleaving enzyme 1), also is a potent antimitotic compound which inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells.

S9775 SCR130 SCR130 is a novel DNA repair inhibitor with IC50s of 14 μM in Reh cells and 2 μM in Nalm6 cells. SCR130 specifically inhibits DNA Ligase IV‐mediated joining with minimal or no effect on Ligase III and Ligase I mediated joining.
S8043 Scriptaid Scriptaid (GCK 1026) is an inhibitor of HDAC. It shows a greater effect on acetylated H4 than H3.
E3849 Scrophularia Ningpoensis Extract
S9120 Scutellarein Scutellarein (6-Hydroxyapigenin), extracted from the perennial herb Scutellaria lateriflora, has antioxidant, antitumor, anti-adipogenic, antiviral and anti-inflammatory activities
S6371 Scutellarein tetramethyl ether Scutellarein tetramethyl ether (Tetra-O-methylscutellarein, 4',5,6,7-Tetramethoxyflavone), a bioactive component of Siam weed extract, exhibits anti-inflammatory activity through NF-κB pathway. Scutellarein tetramethyl ether modulats bacterial drug resistance via efflux pump inhibition and can enhance blood coagulation.
E3051 Scutellaria Barbata Extract
E3316 Scutellariae rhizome Extract

Scutellariae rhizome Extract is isolated from the rhizome of <i>Scutellaria baicalensis</i>, which contains baicalin as a main constituent, has long been used in China, Japan, and Korea as a traditional medicine and functional food for inflammation, fever, hepatitis, allergic disease, hypertension, etc.

S3810 Scutellarin Scutellarin (Breviscapine, Breviscapin, Scutellarein-7-glucuronide), the major active principal flavonoids extracted from the Chinese herbal medicines Scutellaria baicalensis and Erigeron breviscapus (Vant.) Hand-Mazz, has many pharmacological effects, such as antioxidant, antitumor, antiviral, and antiinflammatory activities. Scutellarin can down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts.
S6176 Scyllo-Inositol Scyllo-Inositol (Scyllitol, Cocositol, Quercinitol, AZD 103, Scyllo-Cyclohexanehexol) is a naturally occurring plant sugar alcohol found most abundantly in the coconut palm.
S6502 SD 0006 SD0006 is an inhibitor of p38 kinase-alpha (p38alpha) with IC50 values of 0.016 μM and 0.677 μM for p38α and p38β. It is selective for p38α kinase over 50 other kinases screened (including p38γ and p38δ with modest selectivity over p38β).
S7624 SD-208 SD-208 is a selective TGF-βRI (ALK5) inhibitor with IC50 of 48 nM, >100-fold selectivity over TGF-βRII.
S0388 SD169 SD-169(5-Carbamoylindole) is a selective inhibitor of p38α MAPK, which can reduce p38 and HSP60 expression in T cells of the pancreatic beta islets.
S5838 SDMA SMDA (symmetric dimethylarginine) is a methylated form of arginine found within all nucleated cells that is released into circulation after proteolysis, then excreted through the kidneys, and correlates well with GFR (glomerular filtration rate) in people, dogs, and cats.
E3605 Sea buckthorn Extract (fruits)

Sea buckthorn Extract (fruits) is extracted from the fruits of sea buckthorn (<i>Hippophae rhamnoides</i> L.). Sea buckthorn has significant cardioprotective activity and exerts many positive healing effects on the cardiovascular system, including inhibiting blood platelet activation (especially platelet aggregation), lowering cholesterol concentration and blood pressure, and providing antioxidant activity.  Sea buckthorn also has antibacterial and antiviral properties. 

E3606 Sea buckthorn Extract (leaves) Sea buckthorn Extract (leaves) is extracted from the leaves of sea buckthorn (Hippophae rhamnoides L.). Sea buckthorn has significant cardioprotective activity and exerts many positive healing effects on the cardiovascular system, including inhibiting blood platelet activation (especially platelet aggregation), lowering cholesterol concentration and blood pressure, and providing antioxidant activity. Sea buckthorn also has antibacterial and antiviral properties.
S6920 SEA0400 SEA0400 is a selective and potent inhibitor of the Na+-Ca2+ exchanger (NCX) that inhibits Na+-dependent Ca2+ uptake in cultured neurons, astrocytes, and microglia with IC50 of 33 nM, 5.0 nM and 8.3 nM, respectively. SEA0400 prevents sodium nitroprusside (SNP) from increasing ERK and p38 MAPK phosphorylation and production of reactive oxygen species (ROS) in an extracellular Ca(2+)-dependent manner.
S5732 Sebacic acid Sebacic acid (1,8-Octanedicarboxylic acid) is a saturated, straight-chain naturally occurring dicarboxylic acid
S2973 SEC inhibitor KL-1 SEC inhibitor KL-1 (KL-1) is a potent and selective inhibitor of super elongation complex (SEC) that disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. KL-1 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with Ki of 3.48 μM.
S9173 Sec-O-Glucosylhamaudol Sec-O-Glucosylhamaudol (Hamaudol 3-glucoside) is one of the major bioactive compounds of the Saposhnikoviae Radix.
S7685 SecinH3 SecinH3 is a selective cytohesin inhibitor with IC50 of 2.4 μM, 5.4 μM, 5.4 μM, 5.6 μM, 5.6 μM, and 65 μM for hCyh2, hCyh1, mCyh3, hCyh3, drosophila steppke, and yGea2-S7, respectively.
S6722 Seclidemstat (SP-2577) Seclidemstat (SP-2577) is a potent and orally bioavailable inhibitor of lysine-specific demethylase 1 (LSD1/KDM1A) with IC50 of 127 nM. Seclidemstat (SP-2577) has potential antineoplastic activity.
S2537 Secnidazole Secnidazole (Flagentyl, PM 185184, RP 14539) is a nitroimidazole anti-infective.
S3780 Secoisolariciresinol diglucoside Secoisolariciresinol diglucoside (SDG), a plant lignan isolated from flaxseed, has strong antioxidant activity, cardioprotective effects, reduces the blood levels of low-density lipoprotein cholesterol, and reduces the risk of hormone related cancer.
A2025 Secukinumab (anti-IL-17A) Secukinumab (anti-IL-17A) (Cosentyx, AIN457) is a human IgG1κ monoclonal antibody that binds to the protein interleukin (IL)-17A, and is applied for the treatment of psoriasis, ankylosing spondylitis, and psoriatic arthritis. MW=147.9 kDa.
S9249 Securinine Securinine, a major natural alkaloid product from the root of the plant Securinega suffruticosa, acts as a γ-amino butyric acid (GABA) receptor antagonist.
E3222 Sedum Aizoon Extract
E3719 Seed of Chinese Tallowtree Extract
E0937 Segesterone acetate Segesterone acetate (Nestoron, ST-1435) is a synthetic progestin that binds to the progesterone receptor with EC50 of 50.3 nM.
E2292 Segetalin B Segetalin B, a cyclopentapeptide from Vaccaria segetalis, possesses estrogen-like activity.
S8840 SEL120 (SEL120-34A) hydrochloride SEL120 (SEL120-34, SEL120-34A) is a novel inhibitor of Cyclin-dependent kinase 8 (CDK8) with IC50 values of 4.4 nM and 10.4 nM for CDK8/Cyclin C and CDK19/CyclinC respectively.
S6888 SEL201 SEL-201 (SLV-2436, SEL201-88) is a highly potent and ATP-competitive inhibitor of MNK1 and MNK2 with IC50 of 10.8  nM and 5.4 nM, respectively.
E3646 Selaginella Doederleinii Extract
E3378 Selaginella Extract
S5247 Selamectin Selamectin (UK-124114) is a novel macrocyclic lactone of the avermectin class. It paralyses and/or kills a wide range of invertebrate parasites through interference with their chloride channel conductance causing disruption of normal neurotransmission and has adulticidal, ovicidal and larvicidal activity against fleas.
S8684 Selective JAK3 inhibitor 1 Selective JAK3 inhibitor 1 is an irreversible JAK3 inhibitor with Ki values of 0.07 nM, 320 nM, 740 nM for JAK3, JAK1 and JAK2 respectively. It is also selective over the other kinases possessing a cysteine in the same region as JAK3, such as BMX, EGFR, ITK, and BTK.
S8693 Selective PI3Kδ Inhibitor 1 (compound 7n) Selective PI3Kδ Inhibitor 1 (compound 7n) is an inhibitor of PI3Kδ with an IC50 of 0.9 nM and >1000-fold selectivity against other class I PI3K isoforms [PI3K α/γ/β=3670/1460/21300 nM].
S8560 Seletalisib (UCB-5857) Seletalisib (UCB-5857) is a novel small-molecule inhibitor of PI3Kδ with an IC50 value of 12 nM and shows significant selectivity to PI3Kδ with respect to the other class I PI3K isoforms (between 24- and 303-fold).
S3726 Selexipag Selexipag (NS-304, ACT-293987) is an orally active, first-in-class, selective prostacyclin IP receptor agonist with Ki value of 260 nM for human IP, whereas Ki values > 10,000 nM are measured at the other human G-protein-coupled prostanoid receptors (EP1-4, DP, FP and TP).
S7252 Selinexor (KPT-330) Selinexor (KPT-330, ATG-010) is an orally bioavailable selective CRM1 inhibitor. Phase 2.
S1541 Selisistat (EX 527) Selisistat (EX 527, SEN0014196) is a potent and selective SIRT1 inhibitor with IC50 of 38 nM in a cell-free assay, exhibits >200-fold selectivity against SIRT2 and SIRT3. Phase 2.
S8636 Selitrectinib (LOXO-195) Selitrectinib (LOXO-195, BAY 2731954) is an orally available, highly potent, and selective TRK kinase inhibitor with low nanomolar inhibitory activity against TRKA G595R, TRKC G623R, and TRKA G667C, IC50s ranging from 2.0 to 9.8 nmol/L. It is more than 1,000-fold selective for 98% of non-TRK kinases tested.
S8292 Selonsertib (GS-4997) Selonsertib (GS-4997) is a highly selective and potent once-daily oral ASK1 inhibitor with potential anti-inflammatory, antineoplastic and anti-fibrotic activities.
S8781 Selpercatinib (LOXO-292) Selpercatinib (LOXO-292, ARRY-192) is a potent and specific RET (c-RET) inhibitor with IC50 values of 1 nM, 2 nM, 2 nM, 4 nM, 2 nM, 2 nM for WT RET, RET V804M, RET V804L, RET A883F, RET M918T and RET S891A respectively.
S3503 Seltorexant Seltorexant (JNJ-42847922) is a potent, selective and orally active antagonist of orexin-2 receptor (OX2R) with pKi of 8.0 and 8.1 for human OX2R and rat OX2R, respectively. Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain.
S1008 Selumetinib (AZD6244) Selumetinib (AZD6244, ARRY-142886) is a potent, highly selective MEK inhibitor with IC50 of 14 nM for MEK1 and Kd value of 530 nM for MEK2. It also inhibits ERK1/2 phosphorylation with IC50 of 10 nM, no inhibition to p38α, MKK6, EGFR, ErbB2, ERK2, B-Raf, etc. Selumetinib suppresses cell proliferation, migration and trigger apoptosis. Phase 3.
S1594 Semagacestat (LY450139) Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, also inhibits Notch signaling with IC50 of 14.1 nM in H4 human glioma cell. Phase 3.
S9697 Semaglutide Semaglutide (Rybelsus, Ozempic, NN9535, OG217SC, NNC 0113-0217), a long-acting glucagon-like peptide 1 (GLP-1) analogue, is a GLP-1 receptor agonist with the potential for the treatment of type 2 diabetes mellitus (T2DM).
P1141 Semax Semax (Met-Glu-His-Phe-Pro-Gly-pro) is an analog of the adrenocorticotropic hormone fragment, which activates the transcription of neurotrophic factors and has neuroprotective and pro-intellectual activities.
S2845 Semaxanib (SU5416) Semaxanib (SU5416, semaxinib) is a potent and selective VEGFR(Flk-1/KDR) inhibitor with IC50 of 1.23 μM, 20-fold more selective for VEGFR than PDGFRβ, lack of activity against EGFR, InsR and FGFR. Phase 3.
E3679 Semen aesculi Extract
E3608 Semen astragali complanati Extract Semen astragali complanati Extract is extracted from Semen Astragali Complanati, the dried ripe seed of Flatstem Milkvetch (Astragalus complanatus Bunge) (Leguminosae). The major contents of Semen astragali complanati include fatty acids, amino acids, polysaccharides, flavonoids, triterpene glycosides and trace elements. Semen astragali complanati exhibits a number of therapeutic effects on chronic diseases such as cardiovascular diseases, diabetes mellitus and cancers.
E3142 Semen Canavaliae Extract
E3576 Semen celosiae Extract
E3019 Semen Ginkgo Extract
E3012 Semen Lablab Album Extract
E3414 Semen litchi Extract
E3684 Semen Persicae Extract
E3846 Semen Pruni Extract
E3677 Semen Ziziphi Spinosae Extract
E3690 Semiaquilegiae Radix Extract
E3260 Seminis Juglandis Septum Extract
E0569 Sempervirine

Sempervirine is an alkaloid compound derived from <i>Gelsemium elegans Benth.</i>, possessing inhibition on the growth of glioma cancer. 

E2729 Sempervirine nitrate

Sempervirine is an indole alkaloid isolated from <i>Gelsemium sempervirens</i> with anti-tumor activities.

S6247 Senecioic acid Senecioic acid (3-Methylcrotonic acid, 3,3-Dimethylacrylic acid, β-Methylcrotonic Acid) is an unsaturated fatty acid found in the pheromones of mealybug species and appears in the urine of patients with 3-Methylcrotonic aciduria.
E2302 Senecionine Senecionine is a pyrrolizidine alkaloid isolated from Senecio vulgaris. Senecionine is toxic to animals and humans.
E2298 Seneciphylline

Seneciphylline, a toxic pyrrolizidine alkaloid in Senecio plants, significantly increases the activities of epoxide hydrase and glutathione-S-transferase but causes reduction of cytochrome P-450 and related monooxygenase activities.

S9095 Senegenin Senegenin (Tenuigenin) is a natural product from Polygala tenuifolia used in Chinese medicine with antioxidative and antiinflammatory activity.
S8520 Senexin A Senexin A is a potent and selective inhibitor of CDK8 and its nearest relative, CDK19 with Kd values of 0.83 μM and 0.31 μM for CDK8 and CDK19 ATP site binding, respectively.
E0501 Senicapoc (ICA-17043) Senicapoc (ICA-17043) is a Gardos channel(Ca2+-activated K+ channel; KCa3.1) blocker with an IC50 of 11 nM and produces dose-dependent increases in hemoglobin and decreases in markers of hemolysis. Senicapoc blocks Ca2+-induced rubidium flux from human RBCs with an IC50 value of 11 nM and inhibits RBC dehydration with IC50 of 30 nM.
S9513 Senkyunolide A Senkyunolide A is one of the major bioactive ingredients in Rhizoma Chuanxiong, a Chinese medicinal herb commonly used for the treatment of cardiovascular ailments.
E2171 Senkyunolide H
S3275 Senkyunolide I Senkyunolide I (SEI, SENI) is an orally active compound isolated from Ligusticum chuanxiong with analgesic, anti-migraine, neuroprotective, anti-oxidation and anti-apoptosis activities. Senkyunolide I (SEI, SENI) up-regulates the phosphorylation of Erk1/2 and induces Nrf2 nuclear translocation with enhanced HO-1 and NQO1 expressions. Senkyunolide I (SEI, SENI) promotes the ratio of Bcl-2/Bax and inhibits the expressions of cleaved caspase 3 and caspase 9.
E3186 Sennae Folium Extract
E2490 Sennidin B Sennidin B, a stereoisomer isolated from the leaves of Cassia angustifolia, inhibits HCV NS3 helicase and induces phosphorylation of Akt and glucose transporter 4 (GLUT4) translocation.
S4033 Sennoside A Sennoside A (NSC 112929), a kind of irritant laxative isolated from rhei rhizome, causes purgative actions in the intestine.
S4018 Sennoside B Sennoside B, a kind of irritant laxative isolated from rhei rhizome, inhibits PDGF-stimulated cell proliferation.
S6391 Sephin-1 Sephin-1 (NSC-65390) is a selective inhibitor of a holophosphatase, a small molecule that safely and selectively inhibits a regulatory subunit of protein phosphatase 1 in vivo. Sephin-1 (NSC-65390) selectively bounds and inhibits the stress-induced PPP1R15A.
S5995 Sepimostat Sepimostat (FUT-187 free base) is an inhibitor of Ifenprodil binding with Ki of 27.7  μM. Sepimostat is an antagonist of NR2B N-methyl-D-aspartate receptor acting at the Ifenprodil-binding site of the NR2B subunit with neuroprotective activity.
S8581 Serabelisib (TAK-117) Serabelisib (TAK-117, INK-1117, MLN-1117) is a potent and selective oral PI3Kα isoform inhibitor (IC50 of 21 nmol/L against PI3Kα) that has demonstrated > 100-fold selectivity relative to other class I PI3K family members (PI3Kβ/γ/δ) and mTOR, and a high degree of selectivity against many other kinase.
E0050 Seralutinib (GB002) Seralutinib (PK10571, GB002) is a novel PDGFR kinase inhibitor with IC50s of 8 nM and 10 nM for PDGFRα and PDGFRβ in enzyme assays, respectively.
S2072 Seratrodast(AA-2414) Seratrodast (AA-2414, ABT-001) is a potent and selective thromboxane A2 receptor (TP) antagonist which is used primarily in the treatment of asthma and used as anti-inflammatory agent.
S1172 Serdemetan (JNJ-26854165) Serdemetan (JNJ-26854165) acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells, inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53. Phase 1.
P1128 Sermorelin

Sermorelin, a 29 amino acid analogue of human growth hormone-releasing hormone (GHRH), is the shortest synthetic peptide with full biological activity of GHRH.

S3344 Serotonin creatinine sulfate monohydrate

Serotonin (5-Hydroxytryptamine) creatinine sulfate monohydrate is an active endogenous metabolite.

S4244 Serotonin HCl Serotonin HCl (5-HT) is a monoamine neurotransmitter and Endogenous 5-HT receptor agonist.
S3161 Sertaconazole nitrate Sertaconazole nitrate (FI-7045) is a topical broad-spectrum antifungal that is developed to provide an additional agent for the treatment of superficial cutaneous and mucosal infections.
S4053 Sertraline HCl Sertraline HCl (CP-51974-1) is a 5-HT antagonist with Ki of 13 nM.
S2392 Sesamin Sesamin (Fagarol, Fsesamin), a lignan isolated from the bark of Fagara plants and from sesame oil, exhibits various health benefits.
S3626 Sesamol Sesamol (1,3-Benzodioxol-5-ol, 3,4-Methylenedioxyphenol), a natural organic compound, is regarded as a major antioxidant component in the oil with chemoprevention, antimutagenic, and antihepatotoxic activities. It induces apoptosis of cancer and cardiovascular cells.
E0906 Sesamolin

Sesamolin ((+)-sesamolin) from sesame seed inhibits proliferation by inducing apoptosis in human lymphoid leukemia Molt 4B cells.

S7171 Setanaxib (GKT137831) Setanaxib (GKT137831, GKT831) is a potent, dual NADPH oxidase NOX1/NOX4 inhibitor with Ki of 110 nM and 140 nM, respectively. Treatment with GKT137831 suppresses reactive oxygen species (ROS) production. GKT137831 partly inhibits ferroptosis.
E3231 Setariae Fructus Germinatus Extract
S5753 Setipiprant (ACT-129968) Setipiprant (ACT-129968, KYTH-105) is a selective, orally available antagonist of the prostaglandin D2 receptor 2 (DP2) that that has been shown to have greater specificity for DP2 (CRTH2) than for DP1.
E1002 Setmelanotide (RM-493)

Setmelanotide (RM-493, BIM-22493, CAM 4072) is a cyclic peptide full agonist of melanocortin-4 receptor (MC4R) with an EC50 of 0.27 nM and a Ki of 2.1 nM.

S4134 Sevelamer Carbonate Sevelamer carbonate is a non-absorbed phosphate binding crosslinked polymer, with the same polymeric structure as sevelamer hydrochloride, in which carbonate replaces chloride as the counterion.
S4129 Sevelamer HCl Sevelamer HCl is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption.
S2464 Sevoflurane Sevoflurane (Fluoromethyl) is a noncompetitive inhibitor of 5-HT3 receptor. Sevoflurane acts as a low-soluble inhalation anesthetics.
S7310 SF1670 SF1670 is a highly potent and specific PTEN inhibitor with IC50 of 2 μM.
S8589 SF2523 SF2523 is a highly selective and potent inhibitor of PI3K with IC50 values of 34 nM, 158 nM, 9 nM, 241 nM and 280 nM for PI3Kα, PI3Kγ, DNA-PK, BRD4 and mTOR, respectively.
S3457 SGA360 SGA360 is a selective modulator of aryl hydrocarbon (Ah) receptor that exhibits anti-inflammatory properties.
S7079 SGC 0946 SGC 0946 is a highly potent and selective DOT1L methyltransferase inhibitor with IC50 of 0.3 nM in a cell-free assay, is inactive against a panel of 12 PMTs and DNMT1.
S7256 SGC-CBP30 SGC-CBP30 is a potent CREBBP/EP300 inhibitor with IC50 of 21 nM and 38 nM in cell-free assays, respectively. Exhibits 40-fold and 250-fold selectivity for CBP over the first BRD of BRD4 (BRD4(1)) and BRD4(2) respectively.
S6710 SGC-GAK-1 SGC-GAK-1 is a potent, selective, and cell-active inhibitor of cyclin G-associated kinase (GAK) with Ki value of 3.1 nM and >50-fold selectivity over nearest kinase.

SGC-SMARCA-BRDVIII is a potent and selective SMARCA2/4 BRD inhibitor.

S3482 SGC2085 hydrochloride SGC2085 hydrochloride is a potent and selective inhibitor of coactivator associated arginine methyltransferase 1 (CARM1) with IC50 of 50 nM.
S7276 SGI-1027 SGI-1027 (DNA Methyltransferase Inhibitor II) is a DNMT inhibitor with IC50 of 6, 8, 7.5 μM for DNMT1, DNMT3A, and DNMT3B in cell-free assays, respectively. SGI‑1027 induces apoptosis.
S2198 SGI-1776 free base SGI-1776 free base is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM in a cell-free assay, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. SGI-1776 induces apoptosis and autophagy. Phase 1.
S7847 SGI-7079 SGI-7079, a novel selective Axl inhibitor with an IC50 of 58 nM in vitro, inhibits tumor growth in a dose dependent manner and is a potential therapeutic target for overcoming EGFR inhibitor resistance.
S9954 SGN-2FF

SGN‐2FF (2-fluorofucose) is an orally bioavailable small‐molecule inhibitor of fucosyltransferase that demonstrated encouraging preclinical antitumor activity in mouse models.

S1112 SGX-523 SGX-523 is a selective Met (c-Met) inhibitor with IC50 of 4 nM, no activity to BRAFV599E, c-Raf, Abl and p38α. Phase 1.
S0751 SHA 68 SHA 68 is a potent and selective antagonist of non-peptide neuropeptide S receptor (NPSR) with IC50 of 22.0 nM and 23.8 nM for NPSR Asn107 and NPSR Ile107, respectively. SHA 68 limits the blood-brain barrier (BBB) penetration and the activity in neuralgia.
E2336 Shancigusin I Shancigusin I is a natural compound found in Cremastra appendiculata.
S9307 Shanzhiside methyl ester Shanzhiside methylester is a principle effective iridoid glycoside of L. rotata and serves as a small molecule glucagon-like peptide-1 (GLP-1) receptor agonist.
E2282 Shanziside Shanziside is an iridoid glucoside isolated from Phlomis tuberosa L. (Lamiaceae).
S3469 Shield-1 Shield-1 is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP). Shield-1 reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused proteins. Shield-1 stabilizes the entire fusion protein.
E3757 Shiitake Mushroom Extract
S2356 Shikimic Acid Shikimic acid (Shikimate), more commonly known as its anionic form shikimate, is an important biochemical intermediate in plants and microorganisms.
S8279 Shikonin (C.I. 75535) Shikonin (C.I. 75535, Anchusin, Anchusa acid, Alkanna Red, Isoarnebin 4, NSC 252844), a potent and specific Pyruvate kinase M2 (PKM2) inhibitor, is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities. It is also an inhibitor of TMEM16A chloride channel activity using cell-based fluorescent-quenching assay. Shikonin exerts an anti-inflammatory effect by inhibiting tumor necrosis factor-α (TNF-α) and prevents activation of nuclear factor-κB (NF-κB) pathway via proteasome inhibition.
E3742 SHILAJIT Asphaltum Extract
S9261 Shionone

Shionone is a triterpenoid component derived from the herbal medicine Aster tataricus, anit has anti-inflammatory properties. Shionone specifically inhibits NLRP3 inflammasome activation in vitro and in vivo.

S6388 SHP099 SHP099 is a highly potent, selective and orally bioavailable small-molecule SHP2 inhibitor with an IC50  value of  71 nM and shows no activity against SHP1.
S8278 SHP099 HCl SHP099 is a highly potent, selective and orally bioavailable small-molecule SHP2 inhibitor with an IC50 value of 0.071 μM and shows no activity against SHP1.
E3505 Shrubalthea Flower Extract
S0632 SIA Crosslinker SIA Crosslinker is a non-cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
E2297 Siamenoside I

Siamenoside I is one of the mogrosides that has several kinds of bioactivities.

S2645 SIB 1757 SIB 1757 is a highly selective, noncompetitive antagonist of metabotropic glutamate receptor type 5 (mGluR5) with IC50 of 0.4 μM at hmGluR5 compared with >30 µM at hmGluR1b, hmGluR2, hmGluR4, hmGluR6, hmGluR7 and hmGluR8.
S2971 SIBA SIBA (5′-Isobutylthio-5′-deoxyadenosine, 5'-Deoxy-5'-isobutylthioadenosine, 5'-Isobutylthioadenosine) is a synthetic analogue of S-adenosylhomocysteine and is a powerful antipro-liferative drug. SIBA is not only an inhibitor of transmethylation but also interferes with polyamine biosynthesis, probably by blocking aminopropyltransferase.
E2414 Sibiricaxanthone B Sibiricaxanthone B is a xanthone isolated from Polygala tenuifolia.
E0579 Sibiricose A6

Sibiricose A6 is an oligosaccharide ester isolated from <i>Polygalae Radix</i> with potent antioxidant activity.

E3100 Sichuan Pepper Extract
S4684 Sildenafil Sildenafil (Revatio, UK-92480, Viagra) is a Phosphodiesterase 5 Inhibitor with IC50 of 5.22 nM.
S1431 Sildenafil Citrate Sildenafil Citrate, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5), is a well-tolerated and highly effective treatment for erectile dysfunction.
S4683 Sildenafil Mesylate Sildenafil Mesylate is a mesylate form of Sildenafil, an inhibitor of Phosphodiesterase 5.
S2357 Silibinin (NSC 651520) Silibinin (NSC 651520, Silybin, Silibinin A, Silymarin I, Flavobin), the main flavonoid extracted from the milk thistle Silybum marianum, displays hepatoprotective properties in acute and chronic liver injury.
E3073 Silkworm Chrysalis Extract
S2248 Silmitasertib (CX-4945) Silmitasertib (CX-4945) is a potent and selective inhibitor of CK2 (casein kinase 2) with IC50 of 1 nM in a cell-free assay, less potent to Flt3, Pim1 and CDK1 (inactive in cell-based assay). Silmitasertib induces autophagy and promotes apoptosis. Phase 1/2.
S0707 Silmitasertib (CX-4945) sodium salt Silmitasertib (CX-4945) sodium salt is a potent, orally bioavailable and selective inhibitor of casein kinase 2 (CK2) with IC50 of 1 nM against CK2α and CK2α'.
S1613 Silodosin Silodosin (KAD 3213, KMD 3213) is a highly selective α1A-adrenoceptor antagonist, used in treatment of benign prostatic hyperplasia.
A2030 Siltuximab (anti-IL-6) Siltuximab (anti-IL-6) (CNTO 328) is a human-mouse chimeric monoclonal antibody that binds human interleukin-6 (IL-6).
S4822 Silver Sulfadiazine Silver sulfadiazine is a bactericidal for many gram- negative and gram-positive bacteria as well as being effective against yeast.
E3659 Silybum mariamum Extract
E2207 Silychristin

Silychristin is an abundant flavonolignan present in the fruits of Silybum marianum, with antioxidant properties. Silychristin is a potent inhibitor of the thyroid hormone transporter MCT8, and elicits a strong inhibition of T3 uptake with an IC50 of 110 nM.

E0758 Silydianin Silydianin is an active constituent of Silybium marianum, with exhibit anti-collagenase, antitumor and anti-elastase activities, also is a natural protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC50 of 17.38 μM.
S2358 Silymarin Silymarin (Silybin B), a polyphenolic flavonoid extracted from the seeds of Silybum marianum or milk thistle, is used in the prevention and treatment of liver diseases and primary liver cancer.
S5015 Simeprevir (TMC435) Simeprevir (TMC-435, TMC-435350) is a competitive, reversible, macrocyclic, noncovalent hepatitis C virus (HCV) NS3/4A protease inhibitor that acts directly against the hepatitis C virus. It has a medium inhibitory concentration (IC50) <13 nM for all HCV NS3/4A enzymes(genotypes 1a, 1b, 2, 4, 5, and 6), but has an IC50 value of 37 nM for genotype 3.
E0147 Simethicone

Simethicone (Simeticone) is a nonabsorbable, surface-active, antifoaming agent.

S3556 Simetride Simetride, a non-narcotic analgesic, is an ingredient of Kyorin AP2 which is used to treat low back pain, symptomatic neuralgia, headache, menstrual pain and etc.
E0077 Simufilam

Simufilam (PTI-125) is a low toxicity, orally active filamin A (FLNA) activator. PTI-125 preferentially binds altered FLNA and restores its native conformation, restoring receptor and synaptic activities and reducing its α7nAChR/TLR4 associations and downstream pathologies.

E0076 Simufilam dihydrochloride Simufilam (PTI-125) Dihydrochloride is a small molecule modulator that preferentially binds altered FLNA and restores its native conformation, restoring receptor and synaptic activities and reducing its α7nAChR/TLR4 associations and downstream pathologies.
S8925 Simurosertib
S1792 Simvastatin (MK 733) Simvastatin (MK-0733, MK 733) is a competitive inhibitor of HMG-CoA reductase with Ki of 0.1-0.2 nM in cell-free assays. Simvastatin induces ferroptosis, mitophagy, autophagy and apoptosis.
S3235 Sinapine Sinapine is an alkaloid isolated from seeds of the cruciferous species with antioxidant, antitumor and radio-protective activities. Sinapine inhibits the proliferation of Caco-2 cells via downregulation of P-glycoprotein.
S3981 Sinapinic Acid Sinapinic acid (Sinapic acid) is a small naturally occurring hydroxycinnamic acid which belongs to phenylpropanoid family and commonly used as matrix in MALDI mass spectrometry. Sinapinic acid (Sinapic acid) acts as an inhibitor of HDAC, with IC50 of 2.27 mM, and also inhibits ACE-I activity.
E2166 Sinapyl Alcohol
S9227 Sinensetin Sinensetin (Pedalitin Permethyl ether), a natural polymethoxylated flavone, has potent antiangiogenesis activity.
S9057 Sinigrin Sinigrin (Allylglucosinolate, 2-Propenylglucosinolate) is a glucosinolate found in some plants of the Brassicaceae family and exerts various activities including anticancer, anti-inflammatory, antibacterial, antifungal, antioxidant, and wound healing effects.
S9420 Sinoacutine Sinoacutine (Salutaridine), isolated from the Chinese drug Ching-fengteng, elicits mild antitussive properties.
S2359 Sinomenine Sinomenine (Cucoline, Kukoline), a pure alkaloid extracted from the chinese medical plant Sinomenium acutum, is used for the treatment of rheumatism and arthritis.
S3758 Sinomenine hydrochloride Sinomenine (SN, Cucoline, Kukoline, Sabianine A), extracted from the Chinese medicinal plant, sinomenium acutum, is a potent anti-inflammatory and neuroprotective agent.
A2035 Sintilimab (anti-PD-1) Sintilimab (anti-PD-1, IBI 308) is a fully human IgG4 monoclonal antibody that binds to PD-1 on the surface of T-cells, blocks the PD-1/PD-Ligand 1 (PD-L1) pathway, and reactivates T-cells to kill cancer cells.
S7179 Siponimod (BAF312) BAF312 (Siponimod) is a next-generation S1P receptor agonist, selective for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, exhibits >1000-fold selectivity over S1P2, S1P3 and S1P4 receptors. Phase 3.
S6756 Siramesine HCl Siramesine (Lu 28-179) is a sigma receptor agonist, selective for the σ2 subtype with IC50 values of 0.12 nM and 17 nM for σ2 and σ1 receptors respectively.
E1150 SIRT7 inhibitor 97491 SIRT7 inhibitor 97491, a potent SIRT7 inhibitor with an IC50 of 325 nM, reduces deacetylase activity of SIRT7 in a dose-dependent manner. SIRT7 inhibitor 97491 prevents tumor progression by increasing p53 stability through acetylation at K373/382. SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.
S6687 SIS17 SIS17 is a mammalian histone deacetylase 11 (HDAC 11)-specific inhibitor with IC50 of 0.83 μM. SIS17 inhibits the demyristoylation of HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs.
S3552 SIS3 SIS3 is a cell-permeable inhibitor of Smad3 that selectively inhibits TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated cellular signaling. SIS3 reduces TGF-β1-induced type 1 procollagen expression and myofibroblast differentiation in normal dermal fibroblasts as well as scleroderma fibroblasts.
S7959 SIS3 HCl SIS3, a novel specific inhibitor of Smad3, inhibits TGF-β and activin signaling by suppressing Smad3 phosphorylation without affecting the MAPK/p38, ERK, or PI3-kinase signaling pathways.
S4540 Sisomicin sulfate Sisomicin sulfate is an aminoglycoside antibiotic, isolated from the fermentation broth of a new species of the genus Micromonospora.
S2152 Sitafloxacin Hydrate Sitafloxacin Hydrate (DU-6859a) is a new-generation, broad-spectrum oral fluoroquinolone antibiotic.
S5079 Sitagliptin Sitagliptin (MK-0431) is an oral and highly selective DPP-4 inhibitor with an IC50 of 18 nM. It is used for the treatment of type 2 diabetes.
S4002 Sitagliptin phosphate monohydrate Sitagliptin phosphate monohydrate (MK-0431) is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts.
S8573 Sitravatinib (MGCD516) Sitravatinib (MGCD516, MG-516) is a novel small molecule inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Kit, PDGFRβ, PDGFRα, c-Met, and Axl.
S8136 Sivelestat (ONO-5046) Sivelestat (ONO5046, LY544349, EI546) is a potent and selective inhibitor of neutrophil elastase with IC50 of 44nM. It almost shows no activity at a range of other proteases.
S4666 Sivelestat sodium tetrahydrate Sivelestat sodium tetrahydrate (ONO5046-Na, EI546, LY544349) is a competitive inhibitor of human neutrophil elastase, also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse.
E0051 SJ-172550 SJ 172550 is the first MDMX inhibitor that binds reversibly to MDMX and effectively kills retinoblastoma cells in which the expression of MDMX is amplified.
S0153 SJ000291942 SJ000291942 is a canonical bone morphogenetic proteins (BMP) signaling pathway activator.
S0181 SJA710-6 SJA710-6 is a small molecule that can selectively differentiate MSCs toward hepatocyte-like cells.
S0399 SJB2-043 SJB2-043 is a potent USP1 inhibitor that inhibits the activity of native USP1/UAF1 with IC50 of 544 nM.
E1118 SJB3-019A SJB3-019A, a potent USP1 inhibitor, is 5 times more potent than SJB2-043 in promoting inhibitor of DNA-binding-1 (ID1) degradation and cytoxicity with IC50 of 0.0781 μM in K562 cells.
S0311 SKA-31 SKA-31(Naphtho[1,2-d]thiazol-2-ylamine) is a potent potassium channel activator with EC50s of 260 nM, 1.9 μM, 2.9 μM, and 2.9 μM for KCa3.1, KCa2.2, KCa2.1 and KCa2.3, respectively.
S4959 Skatole Skatole (3-methylindole, Scatole) is a mildly toxic white crystalline organic compound that occurs naturally in feces. It has a fairly broad bacteriostatic effect.
S7214 Skepinone-L Skepinone-L (CBS3830) is a selective p38α-MAPK inhibitor with IC50 of 5 nM.
E2630 SKF-86002 SKF-86002 is an orally active p38 MAPK inhibitor, inhibits lipopolysaccharide (LPS)-stimulate human monocyte IL-1 and TNF-α production with IC50 of 1 μM, also inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid.
S7993 SKF38393 HCl SKF38393 HCl is a selective dopamine D1/D5 receptor agonist.
S7999 SKF96365 SKF96365, originally identified as a blocker of receptor-mediated calcium entry, is widely used diagnostically, as a blocker of transient receptor potential canonical type (TRPC) channels.
S7176 SKI II SKI II (SphK-I2) is a highly selective and non ATP-competitive sphingosine kinase (SphK) inhibitor with IC50 of 0.5 μM, while exhibiting no inhibitory action on other kinases including PI3K, PKCα and ERK2.
S5989 SKI-178 SKI-178 is a potent inhibitors of sphingosine kinase-1 (SphK1) and SphK2 with IC50 values ranging from ∼500 nM to ∼1 μM depending on AML cell lines.
S0817 SKI-V SKI V is a noncompetitive and potent inhibitor of non-lipid sphingosine kinase with IC50 of 2 μM for GST-hSK. SKI-V also inhibits PI3K with IC50 of 6 μM for hPI3k. SKI-V decreases formation of the mitogenic second messenger sphingosine-1-phosphate (S1P) and induces apoptosis with antitumor activity.
E2194 Skimmianine Skimmianine, a furoquinoline alkaloid present mainly in the Rutaceae family, with antispastic, anti-inflammatory activities and antiplatelet aggregation effect, exhibits cytotoxicity against a variety of cancer cell lines and genotoxicity.
S6526 SKLB 610 SKLB-610 is a multi-target inhibitor of the tyrosine kinases. It is most potent against VEGFR2 and exhibits slightly weaker inhibitor of FGFR2 and PDGFR.
E1136 SKLB-197 SKLB-197 exerts selectively inhibition against ataxia telangiectasia mutated and Rad3-related (ATR) kinase with IC50 of 0.013 μM, also displays potent antitumor activity against ATM-deficent tumors both in vitro and in vivo.
S8743 SKLB-23bb SKLB-23bb is an orally bioavailable HDAC6-selective inhibitor with IC50 values under 100 nmol/L, against most of the cell lines checked. It also has microtubule-disrupting ability.
S1099 SKLB4771 (FLT3-IN-1) SKLB4771 is a potent and selective inhibitor of human receptor-type tyrosine-protein kinase FLT3 with IC50 of 10 nM.
S8652 Skp2 inhibitor C1 (SKPin C1) Skp2 inhibitor C1 (SKPin C1) is a specific and selective small-molecule inhibitor of Skp2-mediated p27 degradation by reducing p27 binding through key compound-receptor contacts.
E2101 Skullcapflavone II Skullcapflavone II, a flavonoid derived from Scutellaria baicalensis, possesses activities of anti-inflammatory and anti-microbial, also regulates osteoclast differentiation, survival, and function.
S1066 SL-327 SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/ 0.22 μM, no activity towards Erk1, MKK3, MKK4, c-JUN, PKC, PKA, or CamKII;capable of transport through the blood-brain barrier.
S0755 SLC13A5-IN-1 SLC13A5-IN-1 is a selective inhibitor of sodium-citrate co-transporter (SLC13A5). SLC13A5-IN-1 completely blocks the uptake of 14C-citrate with IC50 of 0.022 μM in HepG2 cells. SLC13A5-IN-1 has the potential for the treatment of metabolic and/or cardiovascular diseases.
S0494 SM 324405 SM 324405 (compound 9e) is a potent and selective Toll-like receptor 7 (TLR7) agonist with EC50 of 50 nM.
E0447 SM-102 SM-102 is a amino cationic lipid used to form the nanoparticle which carries the mRNA to cells in the body.
S7089 SM-164 SM-164 is a potent, non-peptide, cell-permeable antagonist of XIAP that targets both the BIR2 and BIR3 domains with IC50 of 1.39 nM. SM-164 induces apoptosis and tumor regression.
S2952 SM-276001 SM-276001 is a potent and selective agonist of TLR7 that induces antitumor immune responses. SM-276001 is an orally active interferon (IFN) inducer.
E0783 SM-7368 SM-7368 is a potent NF-κB inhibitor that targets downstream of MAPK p38 activation, also inhibits TNF-α-induced MMP-9 upregulation.
L4800 Small Molecule Immuno-Oncology Compound Library A unique collection of 248 Immuno-Oncology small molecules used for oncotherapy in conjunction with other drugs.
E3788 Smallanthus Sonchifolius Extract
S0572 SMCC SMCC (Succinimidyl-4-(N-maleimidomethyl cyclohexane)-1-carboxylate) is a hetero-bifunctional crosslinker that contain N-hydroxysuccinimide (NHS) ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl-containing molecules. SMCC-conjugated antigen couples spleen cells to induce antigen-specific immune responses.
S6497 SMI-16a SMI-16a is a selective Pim kinase inhibitor with IC50 values of 150 nM and 20 nM for Pim1 and Pim2 respectively.
S8005 SMI-4a SMI-4a (TCS PIM-1 4a) is a potent inhibitor of Pim1 with IC50 of 17 nM, modestly potent to Pim-2, does not significantly inhibit any other serine/threonine- or tyrosine-kinases.
E1042 SMIFH2

SMIFH2 is a specific inhibitor of formin that inhibits formin-driven actin polymerization in vitro with IC50s ranging from 5 to 15 μM for different formins.

E2314 Smilagenin acetate

Smilagenin acetate is a sapogenin derivative indicated by patent US20030004147A1. Smilagenin acetate increases the expression of acetylcholine m2 receptors and can be used for the research of dementia.

E3705 Smilax glabra Extract
S6384 Smoothened Agonist (SAG)

Smoothened Agonist (SAG) is potent agonist of Smoothened (Smo). Smoothened Agonist induces firefly luciferase expression in Shh-LIGHT2 cells with an EC50 of 3 nM.

S7779 Smoothened Agonist (SAG) HCl Smoothened Agonist (SAG) HCl is a cell-permeable Smoothened (Smo) agonist with EC50 of 3 nM in Shh-LIGHT2 cells.
S0345 Smurf1-IN-A01 Smurf1-IN-A01 can inhibit Smurf1-mediated Smad1/5 degradation and accelerate BMP-2 signal responsiveness with a Kd of 3.664 nM.
E1066 SN-011 (GUN35901) SN-011 (GUN35901) is a STING-specific antagonist with IC50 of 76 nM.
S4908 SN-38 SN-38 (NK012) is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks. SN-38 induces autophagy.
S0016 SN-6 SN-6 is a selective Na+/Ca2+ exchanger (NCX) inhibitor. SN-6 inhibits NCX1, NCX2, and NCX3 with IC50 of 2.9 μM, 16 μM and 8.6 μM, respectively. SN-6 abolishes acetylcholine (ACh)-induced vasodilation.
S6671 SN50 SN50 (NF-κB SN50), a cell-permeable NF-κB inhibitory peptide, is composed of the signal peptide of Kaposi fibroblast growth factor.SN50 inhibits the activation of NF-κB and attenuates ventilator-induced lung injury.
E3626 Snake Gallbladder Extract Snake Gallbladder Extract is extracted from Snake gallbladder. Snake gallbladder has multiple pharmacological effects, such as relieving coughs and asthma, as well as improving human immunity and visual acuity. Snake gallbladder has been believed in various Asian countries to improve visual acuity and alleviate rheumatism
S0080 SNAP94847 hydrochloride SNAP 94847 hydrochloride is a high affinity and selective antagonist of the MCH1 receptor with an IC50 of 230 nM for rat MCH1 in FLIPR calcium mobility assay.
S8996 SNDX-5613 SNDX-5613 is a potent and selective inhibitor of menin-MLL binding with a Ki of 0.15 nM. SNDX-5613 shows anti-proliferative activity against multiple cell lines harboring MLLr translocations (MV4;11, RS4;11, MOLM-13, KOPN-8) with IC50 values ranging from 10-20 nM.
S1145 SNS-032 (BMS-387032) SNS-032 (BMS-387032) has firstly been described as a selective inhibitor of CDK2 with IC50 of 48 nM in cell-free assays and is 10- and 20-fold selective over CDK1/CDK4. It is also found to be sensitive to CDK7/9 with IC50 of 62 nM/4 nM, with little effect on CDK6. SNS-032 (BMS-387032) induces apoptosis. Phase 1.
S1154 SNS-314 SNS-314 is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively. It is less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2. Phase 1.
S8699 SNS-314 Mesylate SNS-314 Mesylate is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively and less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2.
S2639 SNX-2112 (PF-04928473) SNX-2112 (PF-04928473) selectively binds to the ATP pocket of HSP90α and HSP90β with Ka of 30 nM and 30 nM, uniformly more potent than 17-AAG.
S3324 Sodium 2-(1H-indol-3-yl)acetate

Sodium 2-(1H-indol-3-yl)acetate (3-Indoleacetic acid sodium, Indole-3-acetic acid sodium, 3-IAA sodium) is an endogenous metabolite.

S3126 Sodium 2-hydroxybutanoate

Sodium 2-hydroxybutanoate (Sodium 2-hydroxybutyrate, Sodium DL-2-hydroxybutyrate), converted from 2-Aminobutyric acid, is an intermediate metabolite.

S4414 Sodium 4-aminohippurate Sodium 4-aminohippurate is a derivative of hippuric acid.
E2681 Sodium acrylate Sodium acrylate is a metal salt that can be prepared by an acid-base reaction between sodium hydroxide and acrylic acid. 
S3770 Sodium Aescinate Sodium Aescinate (SA, Escin Sodium Salt) is a widely-applied triterpene saponin product derived from horse chestnut seeds, possessing vasoactive and organ-protective activities with oral or injection administration in the clinic. Sodium aescinate is a triterpene saponin derived from Aesculus hippocastanum seeds, with anti-inflammatory and antioxidant activities. Sodium aescinate inhibits hepatocellular carcinoma growth by targeting CARMA3/NF-κB pathway.
S4245 Sodium ascorbate Sodium Ascorbate (Sodium Vitamin C) is a more bioavailable form of vitamin C that is an alternative to taking ascorbic acid as a supplement.
S3750 Sodium benzoate Sodium benzoate (Benzoic acid sodium salt) is a preservative and uesd as a food additive which is bacteriostatic and fungistatic under acidic conditions.
S1999 Sodium butyrate Sodium butyrate (NaB, Butanoic acid sodium salt), sodium salt of butyric acid, is a histone deacetylase inhibitor and competitively binds to the zinc sites of class I and II histone deacetylases (HDACs). Sodium butyrate (NaB) inhibits cell cycle progression, promotes differentiation, and induces apoptosis and autophagy in several types of cancer cells.
S4828 Sodium carbonate Sodium Carbonate (Disodium carbonate, Soda Ash, Carbonic acid disodium salt) is the disodium salt of carbonic acid with alkalinizing property.
S5599 Sodium cholate Sodium cholate (NaCh) is the sodium salt of the naturally occurring cholic acid, a bile salt produced by the liver, with strong solubilization capacity of water-insoluble substances.
S6446 Sodium citrate dihydrate Sodium citrate dehydrate (Trisodium citrate dihydrate, Citric acid trisodium salt dihydrate) is the preferred anticoagulant.
S2401 Sodium Danshensu Sodium Danshensu is a mono sodium of danshensu, which is a natural phenolic acid of caffeic acid derivatives isolated from Salvia miltiorrhiza.
S6235 Sodium dehydroacetate Sodium dehydroacetate is the sodium salt of dehydroacetic acid, a fungicide and bactericide that is commonly used as a food preservative. Sodium dehydroacetate is a preservative that is used in the formulation of cosmetics and personal care products in order to extend the shelf-life by preventing microbial contamination.
S5765 Sodium Dehydrocholate Sodium Dehydrocholate is a semisynthetic bile acid made from cholic acid. It has been used for stimulation of biliary lipid secretion.
S3861 Sodium Demethylcantharidate Demethylcantharidin (norcantharidin) is a synthetic analogue of cantharidin and has potent antitumor activity.
S8615 Sodium dichloroacetate (DCA) Sodium dichloroacetate (DCA, Dichloroacetic acid, bichloroacetic acid, BCA), a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress Na+-K+-2Cl- cotransporter and a mitochondrial potassium-ion channel axis. Sodium dichloroacetate increases reactive oxygen species (ROS) generation, triggers apoptosis in cancer cells, and inhibits tumor growth.
S5133 Sodium erythorbate Sodium erythorbate (NaE, D-Isoascorbate, Erythorbic acid sodium salt, Araboascorbic acid monosodium salt, Erbit N, Eribate N, Isoascorbate C sodium) is the sodium of erythorbic acid, a highly refined food-grade chemical closely related to vitamin C, synthesized from sugar, and used as a color fixative in preparing cured meats.
S5198 Sodium Etidronate Sodium Etidronate (Didronel, EHDP, Etidronic acid) is a non-aminobisphosphonate that exhibits protein tyrosine phosphatase (PTP) inhibitory activity.
S4740 Sodium ferulate Sodium ferulate (SF, Ferulic acid sodium salt), the sodium salt of ferulic acid, is a drug used in traditional Chinese medicine for treatment of cardiovascular and cerebrovascular diseases and to prevent thrombosis.
S4613 Sodium Fluoride Sodium fluoride (NaF) induces apoptosis and autophagy via the endoplasmic reticulum (ER) stress pathway in MC3T3-E1 osteoblastic cells.
S2587 Sodium Glucoheptonate Dihydrate Sodium glucoheptonate is used for cleaning metal, mercerizing, paint stripping, and aluminum etching.
S4174 Sodium Gluconate Sodium gluconate is the sodium salt of gluconic acid widely used in food and pharmaceutical industry.
S5322 Sodium gualenate Sodium gualenate (Guaiazulenesulfonate sodium), a hydrophilic derivative of guaiazulene (GA), is an unstable compound, which is gradually decomposed in the solid state at room temperature. It has anti-inflammatory and wound-healing effects.
S3801 Sodium Houttuyfonate Sodium Houttuyfonate, the active compound of the Houttuynia plant, is mainly used for treating purulent skin infections, respiratory tract infections, including pneumonia in elderly patients, and chronic bronchitis.
S5650 Sodium Hyaluronate Sodium hyaluronate is the sodium salt of hyaluronic acid, a glycosaminoglycan found in various connective tissue of humans.
E0100 Sodium ionophore III Sodium ionophore III (ETH2120) is a Na+ ionophore suitable for the assay of sodium activity in blood, plasma, serum. etc.
S5115 Sodium L-ascorbyl-2-phosphate Sodium L-ascorbyl-2-phosphate (Sodium ascorbyl monophosphate, Sodium ascorbyl phosphate, SAP) is specifically produced for use as a stabilized source of vitamin C in cosmetic products. It is used in skin care recipes for UV protection, collagen production, as an antioxidant and for its skin lightening and brightening effects. Sodium L-ascorbyl-2-phosphate (2-Phospho-L-ascorbic acid trisodium salt, L-Ascorbic acid 2-phosphate trisodium salt, Sodium ascorbyl phosphate, SAP) is a selective antioxidant and a stimulator of hepatocyte growth factor (HGF) production.
S6010 Sodium L-lactate Sodium L-lactate is used as a food additive, preservative, acidity regulator and bulking agent.
S6218 Sodium lauryl sulfate Sodium lauryl sulfate is an anionic detergent and surfactant found in many personal care products.
S2992 Sodium mesoxalate monohydrate

Sodium mesoxalate monohydrate (sodium 2,2-dihydroxymalonate) is an endogenous metabolite.

S5525 SodiuM Metatungstate Sodium metatungstate (SMT) solution is an inorganic heavy liquid which is widely used in density fractionation. Sodium metatungstate (Sodium polyoxotungstates) is a potent and selective inhibitor of ecto-nucleoside triphosphate diphosphohydrolase (NTPDases, CD39) with Ki of 0.140 μM, 0.910 μM and 0.563 μM for NTPDase1, NTPDase2 and NTPDase3, respectively.
S2324 Sodium Monensin (NSC 343257) Sodium Monensin (NSC 343257), isolated from Streptomyces cinnamonensis, is a well-known representative of naturally polyether ionophore antibiotics.
S4013 Sodium Monofluorophosphate Sodium Monofluorophosphate (NSC248) is a competitive inhibitor of pyruvate kinase and alkaline phosphatase with Ki of 3.4 mM and 69 μM, respectively, which also irreversibly inhibits phosphorylase phosphatase with Ki of 0.5 mM.
S4074 Sodium Nitrite Sodium nitrite is a myeloperoxidase inhibitor with IC50 of 1.3 μM.
S4493 Sodium nitroprusside Sodium nitroprusside (SNP, Ro 21-2498) is a generically available and rapid-acting intravenous (IV) vasodilator that dilates cerebral vessels and increases internal carotid (ICA) flow.
S4059 Sodium Nitroprusside Dihydrate Sodium Nitroprusside Dihydrate is a potent vasodilator working through releasing NO spontaneously in blood.
S6871 Sodium oxamate Sodium oxamate (SO, Aminooxoacetic acid, Oxamic acid) is an inhibitor of lactate dehydrogenase (LDH) that specificly inhibits LDH‑A. Sodium oxamate (SO) induces G2/M cell cycle arrest via downregulation of the CDK1/cyclin B1 pathway and promotes apoptosis through enhancement of mitochondrial ROS generation.
S4125 Sodium Phenylbutyrate Sodium phenylbutyrate (4-PBA, 4-Phenylbutyric acid, NaPB) is a salt of 4-phenylbutyrate (4-PBA) or 4-phenylbutyric acid.Sodium phenylbutyrate is a histone deacetylase inhibitor, used to treat urea cycle disorders.
S3351 Sodium phenylpyruvate Sodium phenylpyruvate (Phenylpyruvic acid sodium salt) inhibits amino acid formation and depresses oxygen consumption.
E2701 Sodium phosphate monobasic monohydrate Sodium phosphate monobasic monohydrate is a commonly used buffer which can be used in high-performance liquid chromatography.
S6315 Sodium phytate hydrate Sodium phytate hydrate (Phytic acid, Dodecasodium phytate, Myo-inositol hexakis, Inositol hexakisphosphate) functions as a storage depot and precursor for other inositol phosphates and pyrophosphates. It can be used clinically as a hypocalcemic agent and a complexing agent for removal of traces of heavy metal ions.
S4020 Sodium Picosulfate Sodium Picosulfate inhibits absorption of water and electrolytes, and increases their secretion.
S3137 Sodium salicylate Sodium salicylate is used in medicine as an analgesic and antipyretic.
S2435 Sodium stibogluconate Sodium stibogluconate (SSG, Stibogluconate trisodium nonahydrate, Lenocta, VQD-001), a pentavalent antimony derivative, is a potent and selective inhibitor of protein tyrosine phosphatase (PTPase). Sodium stibogluconate inhibits 99% of Src homology 2 domain-containing phosphatase 1 (SHP-1) activity at 10 μg/ml and similar degrees of inhibition of SHP-2 and PTP1B requires 100 μg/ml. Sodium stibogluconate is a drug used in treatment of leishmaniasis.
S5433 Sodium succinate Sodium succinate (Sodium 3-carboxypropanoate, Disodium butanedioate) is the sodium salt form of succinate, which is an important metabolite at the cross-road of several metabolic pathways and involved in the formation and elimination of reactive oxygen species.
S4634 Sodium sulfadiazine Sodium Sulfadiazine (Sulfadiazin-natrium) is a sodium salt form of sulfadiazine, an intermediate-acting bacteriostatic, synthetic sulfanilamide derivative.
S6463 Sodium tauroglycocholate Sodium tauroglycocholate (STGC, Tauroglycocholic acid sodium salt) is an absorption enhancer of transdermal permeation of drug.
S7896 Sodium Tauroursodeoxycholate (TUDC) Sodium Tauroursodeoxycholate (TUDC) is a water soluble bile salt, used for the treatment of gallstones and liver cirrhosis.
S6281 Sodium Thiocyanate Sodium Thiocyanate (NaSCN, Sodium rhodanide, Sodium sulfocyanate, Sodium rhodanate), one of the main sources of the thiocyanate anion, is used as a precursor for the synthesis of pharmaceuticals and other specialty chemicals. Sodium thiocyanate (NaSCN) reduces IL-6, whereas increases IL-10 levels. Sodium thiocyanate also reduces ROS.
S5450 Sofalcone Sofalcone (SU-88) is an antiulcer drug and a mucosal protective agent, increasing vascular endothelual growth factor via the Nrf2-heme-oxygenase-1 dependent pathway in gastric epithelial cells.
S2794 Sofosbuvir (GS-7977) Sofosbuvir (PSI-7977, GS-7977) is a HCV NS5B polymerase inhibitor for the treatment of chronic hepatitis C virus (HCV) infection.
S2360 Solanesol (Nonaisoprenol) Solanesol (Nonaisoprenol, Betulanonaprenol) is a long-chain polyisoprenoid alcohol compound with inhibitory activities toward FAK. It mainly accumulates in solanaceous crops, including tobacco, tomato, potato, eggplant, and pepper plants.
E2711 Solanidiene

Solanidiene (Solanthrene) is isolated from the leaves of <i>S. tuberosum</i>.

E2713 Solanidine

Solanidine is a cholestane alkaloid isolated from several potato species including Solanum demissum, Solanum acaule, and Solanum tuberosum. Solanidine can inhibit proliferation and exhibit obvious antitumor effect.

E3184 Solanum Lycopersicum Extract
E3037 Solanum lyratum Extract
E3424 Solanum nigrum Extract
S3309 Solasodine Solasodine (Purapuridine, Solancarpidine, Solasodin, Salasodine, Salasdine) is a poisonous alkaloid chemical compound that occurs in plants of the Solanaceae family. Solasodine reduces the mRNA level of matrix metalloproteinase-2 (MMP-2), MMP-9 and extracellular inducer of matrix metalloproteinase (EMMPRIN), but increases the expression of reversion-inducing cysteine-rich protein with kazal motifs (RECK). Solasodine downregulates oncogenic microRNA-21 (miR-21), which has been known to target RECK. Solasodine also reduces PI3K/Akt signaling pathways and downregulates expression of miR-21.
S5917 Solcitinib Solcitinib (GLPG0778, GSK2586184) is an inhibitor of JAK1 with an IC50 of 8-9 nM, and shows 11-, 55- and 23-fold selectivity over JAK2, JAK3 and TYK2, respectively.
E3818 Solidago Decurrens Extract
S5238 Solifenacin (YM905) Solifenacin (YM905) is a competitive muscarinic receptor antagonist. The binding of acetylcholine to these receptors, particularly the M3 receptor subtype, plays a critical role in the contraction of smooth muscle.
S3048 Solifenacin succinate Solifenacin succinate (YM905) is a urinary antispasmodic of the antimuscarinic class.
S5268 Solithromycin Solithromycin (CEM-101, OP-1068), belonging to the well-known class of macrolide antibiotics that also includes azithromycin, is a potent bacterial protein synthesis inhibitor.
E2033 Solnatide

Solnatide is the only compound that can accelerate the clearance of alveolar fluid in clinical trials and has the clinical effect of restoring physiological pulmonary function.

S6101 Solvent Blue 35 Solvent Blue 35 (Sudan Blue II, Oil Blue 35) is a member of the Sudan family of hydrophobic fat-staining dyes, predominantly used for staining triglycerides in animal tissues (frozen sections).
S5165 Solvent Red 23 Solvent Red 23 (Cerasin Red, Sudan III, Sudan Red III, Fettscharlach) is a solvent dye used to color nonpolar substances such as oils, fats, waxes, greases, various hydrocarbon products, and acrylic emulsions.
P1039 Somatostatin Acetate Somatostatin Acetate is a peptide hormone that regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with G protein-coupled somatostatin receptors and inhibition of the release of numerous secondary hormones.
S9065 Songorine Songorine, a ubiquitous alkaloid in the genus Aconitum, is a novel antagonist of the GABAA receptor in rat brain and has antiarrhythmic, antinociceptive, anti-inflammatory, regenerative and CNS-modulating properties.
S2151 Sonidegib (NVP-LDE225) Sonidegib (Erismodegib, NVP-LDE225) is a Smoothened (Smo) antagonist, inhibiting Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human) in cell-free assays, respectively. Phase 3.
S2405 Sophocarpine Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
E2598 Sophoflavescenol

Sophoflavescenol is a prenylated flavonol, which shows great inhibitory activity with IC<sup>50</sup> of 0.013 μM against <b>Phosphodiesterase 5 (PDE5) </b>. Sophoflavescenol also inhibits RLAR, HRAR, AGE, BACE1, AChE and BChE with IC<sup>50</sup>s of 0.30 µM, 0.17 µM, 17.89 µg/mL, 10.98 µM, 8.37 µM and 8.21 µM, respectively.

E3389 Sophora alopecuroides seed Extract
E3387 Sophora flavescens Extract Sophora flavescens Extract (Sophora angustifolia root Extract) is extracted from Chinese traditional herb Kushen (Sophora flavescens Aiton).
E3305 Sophora flower Extract

Sophora flower Extract is extracted from dried flowers of <i>Sophora japonica</i> (Huaihua), which is used in China, Japan and Korea for treating haematemesis and bleeding haemorrhoids.

E3304 Sophora japonica fruit Extract

Sophora japonica fruit Extract (Fructus Sophorae Extract, Rexflavone), isolated from the fruits of <i>Sophora japonica</i>, contains high contents of isoflavones, and is a health functional food ingredient that significantly improves the menopausal index.

E3613 Sophora tonkinensis Extract Sophora tonkinensis Extract is extracted from the dried root ofSophora tonkinensis Gapnep.. Sophora tonkinensis is used in the treatment of pharyngeal and laryngeal diseases. Sophora tonkinensis has hepatoprotective, immunomodulatory, and anticancer effects and produces obvious toxicity to the liver and nervous and cardiovascular systems.
S3895 Sophoridine Sophoridine (5-Epidihydrosophocarpine, Dihydro-5-episophocarpine), a natural product obtained from medicinal plants, has a variety of pharmacological effects, including anti-cancer and anti-arrhythmia, and affects the immune and central nervous systems.
S7397 Sorafenib (BAY 43-9006) Sorafenib (BAY 43-9006, NSC-724772) is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity.
S1040 Sorafenib (BAY 43-9006) tosylate Sorafenib (BAY 43-9006) tosylate is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib Tosylate inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib Tosylate induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity.
S4983 Sorbic acid Sorbic acid (2,4-Hexadienoic acid) is a naturally occurring compound that originated from the unripe berries of the Rowan Tree. It inhibits various bacteria, including sporeformers, at various stages of their life cycle (germination, outgrowth and cell division).
S2393 Sorbitol Sorbitol (Glucitol) is a sugar alcohol and a sugar substitute.
S8103 Sotagliflozin (LX4211) Sotagliflozin (LX4211, LP-802034) is an oral dual SGLT1/SGLT2 inhibitor with IC50 of 36 nM and 1.8 nM, respectively. Phase 3.
S2509 Sotalol HCl Sotalol is a non-selective beta blocker and a potassium channel blocker with an IC50 of 43 μM.
S8830 Sotorasib (AMG510) Sotorasib (AMG510) is a potent KRAS G12C covalent inhibitor with potential antineoplastic activity.This AMG510 is a chiral compound.
S8955 Sotorasib (AMG510) racemate Sotorasib (AMG510) racemate is a racemic of AMG-510 which is a potent KRAS G12C covalent inhibitor with potential antineoplastic activity.
S2791 Sotrastaurin (AEB071) Sotrastaurin (AEB071) is a potent and selective pan-PKC inhibitor, mostly for PKCθ with Ki of 0.22 nM in a cell-free assay; inactive to PKCζ. Phase 2.
E1180 Sovilnesib AMG 650 (Sovilnesib) is an oral, first in class, selective kinesin-like protein KIF18A inhibitor, can be used for the research of cancer.
E2454 Soyasaponin Aa

Soyasaponin Aa is a soyasaponin that exerts an anti-obesity effect in 3T3-L1 adipocytes through downregulation of peroxisome proliferator-activated receptor γ (PPARγ).

E2464 Soyasaponin Ab

Soyasaponin Ab is a soyasaponin that exerts an anti-obesity effect in 3T3-L1 adipocytes through downregulation of peroxisome proliferator-activated receptor γ (PPARγ).

E2455 Soyasaponin Ba Soyasaponin Ba is a soyasaponin isolated from Phaseolus vulgaris, acts as an aldose reductase inhibitors (ARI).
E2456 Soyasaponin Bb Soyasaponin Bb is a soyasaponin isolated from Phaseolus vulgaris , acting as an aldose reductase differential inhibitor (ARDI).
E3307 Soybean Extract Soybean Extract, isolated from the seeds of Soybean, modulates retinoic acid-related genes and shows photo-protective effects, suggesting that soybean Extract could be an anti-ageing ingredient that can be safely used under the sunlight.
E0506 Soybean oil Soybean oil is a vegetable oil extracted from the seeds of the soybean (Glycine max).
S0842 SP-13786 SP-13786 (UAMC-1110)(compound 60) is a potent and selective inhibitor of fibroblast activation protein (FAP) and prolyl oligopeptidase (PREP) with IC50 of 3.2 nM and 1.8 μM, respectively.
E0487 SP-8356 SP-8356, an anti-inflammatory synthetic verbenone derivative, is a CD147 inhibitor with respect to its regulation of breast cancer cell behavior and cancer progression.
S9658 SP-96 SP-96 is a potent, selective and non-ATP-competitive inhibitor of Aurora B with IC50 of 0.316 nM. SP-96 can be used for the research of triple negative breast cancer (TNBC).
S0901 SP141 SP141 is a new class of MDM2 inhibitor that promotes MDM2 auto-ubiquitination and degradation, and reduces levels of MDM2 in pancreatic cancer cell lines, as well as their proliferation and ability to form tumors in nude mice. SP141 inhibits human pancreatic cancer cell growth with IC50 values of less than 0.5 μM (0.38–0.50 μM) in a p53-independent manner.
S7680 SP2509 SP2509 (HCI-2509) is a selective histone demethylase LSD1 inhibitor with IC50 of 13 nM, showing no activity against MAO-A, MAO-B, lactate dehydrogenase and glucose oxidase. SP2509 induces apoptosis and promotes autophagy.
S1460 SP600125 SP600125 (Nsc75890) is a broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 40 nM, 40 nM and 90 nM in cell-free assays, respectively; 10-fold greater selectivity against MKK4, 25-fold greater selectivity against MKK3, MKK6, PKB, and PKCα, and 100-fold selectivity against ERK2, p38, Chk1, EGFR etc. SP600125 is also a broad‐spectrum inhibitor of serine/threonine kinases including Aurora kinase AFLT3 and TRKA with of IC50 of 60 nM, 90 nM and 70 nM. SP600125 inhibits autophagy and activates apoptosis.
S1884 Sparfloxacin Sparfloxacin (AT-4140, CI-978, PD 131501) is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity.
S6665 Sparsentan (PS-433540, RE-021) Sparsentan (PS-433540, RE-021, DARA) is a dual endothelin type A receptor(ETA) and angiotensin II type 1 receptor antagonist.
A2017 Spartalizumab (anti-PD-1) Spartalizumab (anti-PD-1) is a humanized anti-PD-1 IgG4 antibody that blocks the binding of PD-L1 and PD-L2 to PD-1. It binds to PD-1 with high affinity and inhibits the biological activity of PD-1, MW: 145.8 KD.
S9142 Sparteine Sparteine, which could be extracted from scotch broom, is a sodium channel blocker and a class 1a antiarrhythmic agent.
S0801 Spastazoline Spastazoline is a potent, cell-permeable and selective spastin (a microtubule-severing AAA (ATPases associated with diverse cellular activities) protein) inhibitor with IC50 of 99 nM for Human spastin. Spastazoline does not inhibit ATPase activity of a recombinant human VPS4 (another AAA protein required for intercellular bridge disassembly).
S7888 Spautin-1 Spautin-1 is a potent and specific autophagy inhibitor, and inhibits the deubiquitinating activity of USP10 and USP13 with IC50 of ∼0.6-0.7 μM. Spautin-1 enhances apoptosis.
S8431 SPD304 SPD304 is a selective TNF-α inhibitor, which promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor.
S0571 SPDB SPDB is a glutathione cleavable ADC linker applied into the synthesis of antibody-drug conjugate (ADCs).
S0610 SPDB-sulfo SPDB-sulfo is a glutathione cleavable ADC linker applied into the synthesis the antibody-drug conjugates (ADCs).
S0564 SPDP SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable disulfide bonds with cysteine sulfhydryls. SPDP is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs).
S0609 SPDV SPDV is a cleavable ADC linker that can be applied into the diagnosis and treatment of cancer or B cell proliferative disease.
E3422 Spearmint Extract
S7173 Spebrutinib (CC-292) Spebrutinib (CC-292, AVL-292) is a covalent, orally active, and highly selective BTK inhibitor with IC50 of <0.5 nM, displaying at least 1400-fold selectivity over the other kinases assayed. Phase 1.
S9066 Specnuezhenide Specnuezhenide (Nuezhenide), one of the main ingredients of Chinese medicine, has anti-angiogenic and vision improvement effects.
S2510 Spectinomycin 2HCl Spectinomycin 2HCl (Actinospectacin) is a new parenteral antibiotic prepared from Streptomyces spectabilis.
S5417 Spectinomycin dihydrochloride pentahydrate Spectinomycin dihydrochloride pentahydrate (Trobicin) is a widely used antibiotic that inhibits bacterial protein synthesis by blocking translocation of messenger RNA and transfer RNAs on the ribosome.
S3569 Spermidine Spermidine is a natural polyamine that stimulates cytoprotective macroautophagy/autophagy.
S3653 Spermidine trihydrochloride Spermidine (4-Azaoctamethylenediamine), a natural polyamine produced from putrescine and decarboxylated S-adenosylmethionine (dcSAM) by spermidine synthase, is a novel autophagy inducer and negatively modulates N-methyl-d-aspartate (NMDA).
S3948 Spermine Spermine (4,9-Diaza-1,12-dodecanediamine) is a polyamine involved in cellular metabolism found in all eukaryotic cells. It is found in a wide variety of organisms and tissues and is an essential growth factor in some bacteria.
S5524 Spermine Tetrahydrochloride Spermine (Gerontine, Neuridine, Musculamine) is a polyamine involved in cellular metabolism found in all eukaryotic cells. It is a major natural intracellular compound capable of protecting DNA from free radical attack.
E3134 Sphaeranthus Africanus Extract
S2210 Sphingosine Sphingosine (2-amino-4-trans-octadecene-1,3-diol, C18 Sphingosine) is an 18-carbon amino alcohol with an unsaturated hydrocarbon chain, which forms a primary part of sphingolipids, a class of cell membrane lipids that include sphingomyelin, an important phospholipid.
S8810 SPHINX31 SPHINX31 is a SRPK1 inhibiror with an IC50 of 5.9 nM with highly selectivity for SRPK1 over SRPK2 (50-fold) and CLK1 (100-fold).
S0244 SPI-112 SPI-112 is a not cell permeable inhibitor of Src homology region 2 domain-containing phosphatase 2 (SHP-2, PTPN11) with IC50 of 1 μM in cell-free assay.
E3472 Spicate clerodendranthus Extract
S5127 Spiculisporic Acid Spiculisporic acid (4,5-dicarboxy-4-pentadecanolide) is a bioactive γ-butenolide isolated from a marine Aspergillus.
E3069 Spinach Extract
E0524 Spinosad Spinosad, a mixture of spinosyns A and D known as fermentation products of a soil actinomycete, is a biological neurotoxic insecticide with a broader action spectrum, targeting the nicotinic acetylcholine receptor (nAChRs) of the insect nervous system.
S9134 Spinosin Spinosin (Flavoayamenin), a flavone-C-glycoside, is a bioactive ingredient isolated from a traditional Chinese herb Zizyphi Spinosi Semen. It acts as a plant metabolite and an anxiolytic drug.
E3783 Spiraea Salicifolia Extract
S4082 Spiramycin Spiramycin (Formacidine) is a 16-membered ring macrolide (antibiotic).
S5744 Spiramycin I Spiramycin I (Foromacidin A) is a main component of spiramycin, which is a macrolide antimicrobial agent with broad spectrum antibiotic activity.
E3206 Spirodelae Herba Extract
S4054 Spironolactone Spironolactone is a potent antagonist of the androgen receptor with IC50 of 77 nM.
E3444 Spirulina Extract
E2401 SPP-86 SPP-86, a potent and selective cell permeable inhibitor of rearranged during transfection (RET) tyrosine kinase with an IC50 of 8 nM, inhibits RET-induced phosphatidylinositide 3-kinases (PI3K)/Akt and MAPK signaling, also inhibits RET-induced estrogen receptorα (ERα) phosphorylation in MCF7 cells.
S1265 SQ109 SQ109 is a potent inhibitor of the trypomastigote form of the parasite, with IC50 for LLC-MK2 culture-derived trypomastigotes of 50±8 nM, targets MmpL3 (mycobacterial membrane protein large 3) in Mycobacterium tuberculosis.
S8283 SQ22536 SQ22536 (9-(tetrahydrofuran-2-yl)-9h-purin-6-amine) is an inhibitor of adenylyl cyclase with an IC50 of 1.4 μM. It can inhibit PGE1-stimulated increases in cAMP levels in intact human platelets.
S5407 Squalane Squalane (Perhydrosqualene, Dodecahydrosqualene) is a naturally occuring lipid in both plants and animals. It is usually used as an emollient and moisturizer in cosmetics manufacturing.
S4862 Squalene Squalene (Spinacene, Supraene, trans-Squalene), a naturally occurring substance found in plants, animals and humans, is a component of some adjuvants that is added to vaccines to enhance the immune response.
S0094 SR 0987 SR 0987, a SR 1078 analog, is an agonist for T cell-specific RORγ (RORγt) with EC50 of 800 nM. SR 0987 represses PD-1, produces IL17 and is potential for the treatment of cancer.
E2813 SR 11237 SR 11237, a retinoid X receptor (RXR)-specific agonist, can cause RXR/RXR homodimers to form and transactivate a reporter gene containing a RXR-response element.
S0526 SR 19881 SR 19881 is a potent full agonist of ERRγ with EC50 of 0.39 μM and 4.7 μM in a binding assay and a cell-based assay, respectively. SR 19881 is also equipotent on ERRβ with EC50 of 0.63 μM making it an equipotent dual agonist of ERRβ/γ.
E2671 SR 2640 hydrochloride

SR2640 a cysteinyl leukotrienes (CysLTs) receptor antagonist.

E1185 SR-0813 SR-0813 is a potent and selectively ENL/AF9 YEATS domain inhibitor, which exerts IC50 and EC50 values of 25 nM and 205 nM for ENL YEATS domain, respectively.
S8302 SR-12813 SR-12813 is a pregnane X receptor (PXR) agonist and HMG-CoA reductase inhibitor with an IC50 of 850 nM.
S8528 SR-18292 SR-18292 inhibits PGC-1α gluconeogenic activity and reduces co-activation of HNF4α by modulating the interaction between GCN5 and PGC-1α.
S6544 SR-3029 SR-3029 is a potent and selective casein kinase 1δ/1ε (CK1δ/ε) inhibitor with IC50 values of 44 and 260 nM for CK1δ and CK1ε, respectively.
S2132 SR-4370 SR-4370 is a potent and selective inhibitor of class I HDACs with IC50 of 0.13 µM, 0.58 µM, 0.006 µM, 2.3 µM, 3.7 µM for HDAC 1, HDAC 2, HDAC 3, HDAC 8, HDAC 6, respectively.SR-4370 suppresses AR signaling and in vivo prostate tumor growth.
S8894 SR-4835 SR-4835 is a highly selective dual inhibitor of CDK12 and CDK13 with IC50 of 99 nM and Kd of 98 nM for CDK12 and IC50 of 4.9 nM for CDK13. SR-4835 disables triple-negative breast cancer (TNBC) cells. SR-4835 promotes synergy with DNA-damaging chemotherapy and PARP inhibitors.
S0853 SR-717 lithium SR-717 lithium is a non-nucleotide STING agonist that demonstrates broad interspecies and interallelic specificity with EC50 of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 (cGAS KO) cell lines, respectively. SR-717 lithium also induces the expression of clinically relevant targets, including programmed cell death 1 ligand 1 (PD-L1), in a STING-dependent manner. SR-717 lithium exhibits antitumor activity.
S6724 SR1001 SR1001 is a RORα inverse agonist with Ki values of 172 nM and 111 nM for RORα and RORγ respectively.
S5775 SR1078 SR1078, a synthetic ligand for RORα and RORγ, functions as a RORα/γ agonist.
S0128 SR17018 SR17018 is an agonist of mu-opioid-receptor (MOR) binding with GTPγS with EC50 of 97 nM.
S8900 SR18662 SR18662 is an optimized compund based on ML264 that inhibits Krüppel-like factor 5 (KLF5) with IC50 of 4.4 nM. SR18662 reduces the viability of multiple colorectal cancer cell lines. SR18662 induces apoptosis.
S2969 SR3335 SR3335 (ML-176) is a selective and inverse agonist of retinoic acid receptor-related receptor α (RORα) that directly binds to RORα with Ki of 220 nM.
S0812 SR59230A SR59230A is a blood-brain barrier penetrating, potent and selective antagonist of β3-adrenergic receptor with IC50 of 40 nM, 408 nM, and 648 nM for β3, β1, and β2 receptors, respectively.
S0502 SR8278 SR8278 is a competitive antagonist of nuclear heme receptor REV-ERB with an EC50 of 0.47 μM for REV-ERBα.
S7934 SR9243 SR9243 is a potent and selective LXR inverse agonist.
S6567 Src Inhibitor 1 Src Inhibitor 1 is a potent competitive inhibitor of both Src and Lck (IC50 = 44 and 88 nM, respectively), as well as Csk and Yes.
S6654 SRI-011381 SRI-011381 is a novel agonist of the TGF-beta signaling pathway for treatment of Alzheimer's disease.
S3386 SRI-29329

SRI-29329 is a potent, specific inhibitor of CDC-like kinase (CLK) that targets CLK1, 2 and 4, respectively.

S7270 SRPIN340 SRPIN340 is a selective SRPK inhibitor with Ki of 0.89 μM for SRPK1, showing no significant inhibitory activity against more than 140 other kinases..
S9839 SRS11-92 SRS11-92 (AA9), a Ferrostatin-1 (Fer-1) analogue, is a potent inhibitor of ferroptosis. SRS11-92 inhibits ferroptotic cell death induced by Erastin in HT-1080 human fibrosarcoma cells with EC50 of 6 nM.
S9840 SRS16-86 SRS16-86, a novel third-generation ferrostatin, is an inhibitor of ferroptosis.
S6880 SRT-1460 SRT-1460 is a potent and selective activator of Sirtuin 1 (SIRT1) with EC1.5 of 2.9 μM. SRT-1460 reduces cell viability and growth of pancreatic cancer cells and induces apoptosis.
S1129 SRT1720 HCl SRT1720 HCl is a selective SIRT1 activator with EC50 of 0.16 μM in a cell-free assay, but is >230-fold less potent for SIRT2 and SIRT3. SRT1720 induces autophagy.
S7792 SRT2104 (GSK2245840) SRT2104 (GSK2245840) is a selective SIRT1 activator involved in the regulation of energy homeostasis. Phase 2.
S8270 SRT2183 SRT2183 is a small-molecule activator of the sirtuin subtype SIRT1, currently being developed by Sirtris Pharmaceuticals.
S8481 SRT3025 HCl SRT3025 is an orally available small molecule activator of the SIRT1 enzyme.
S8948 SRX3207 SRX3207 is an orally active dual inhibitor of Syk-PI3K with IC50 of 39.9 nM, 31200 nM, 3070 nM, 3070 nM, 244 nM, 388 nM, 9790 nM for Syk, Zap70, BRD41, BRD42, PI3K alpha, PI3K delta, PI3K gamma, respectively. SRX3207 blocks tumor immunosuppression and increases anti-tumor immunity.
S3509 SSD114 hydrochloride SSD114 hydrochloride is a positive allosteric modulator (PAM) of GABAB receptor.
E2718 SSF-109

SSF-109 is a broad-spectrum fungicide which has protective activity against plant disease. SSF-109 inhibits the biosynthesis of ergosterol at the 14α-demethylation step in <i>Botrytis cinerea</i>.

S7167 SSR128129E SSR128129E is an orally-active and allosteric FGFR1 inhibitor with IC50 of 1.9 μM, while not affecting other related RTKs.
S6522 ST 271 ST271 is a tyrphostin-like protein tyrosine kinase (PTK) inhibitor which inhibits phospholipase D (PLD) activity.
S0451 ST034307 ST034307 is a potent and selective inhibitor of adenylyl cyclase 1 (AC1) with IC50 of 2.3 μM.
S3771 Stachydrine Stachydrine (Proline betaine, L-stachydrine, Methyl hygrate betaine) is a quaternary ammonium derivative of proline that occurs widely in Medicago species. It is an osmoprotective compound found in urine. Stachydrine is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood circulation and dispel blood stasis. Stachydrine can inhibit the NF-κB signal pathway.
S3760 Stachydrine hydrochloride Stachydrine is isolated from seed husk and the pulp of the fruit of C. Leonurus, and many other Asian plants and fruits. It has potent anti-metastatic activity and cardioprotective effects. Stachydrine hydrochloride is the major active constituent of Herba Leonuri, which is a potential therapy for cardiovascular diseases. Stachydrine can inhibit the NF-κB signal pathway. Anti-hypertrophic activities.
S5102 Stachyose Stachyose is a natural sugar found in many foods like beans and vegetables.
E0485 Stafia-1 Stafia-1 is the first STAT5a inhibitor that inhibits STAT5a (IC50=22.2 μM, Ki=10.9 μM) with at least 9‐fold selectivity over STAT5b and higher selectivity against other STAT family members.
E3878 Stalactitum Extract
S0818 STAT3-IN-1 STAT3-IN-1 (compound 7d) is an excellent, selective and orally active inhibitor of STAT3 with IC50 of 1.82 μM and 2.14 μM in HT29 and MDA-MB 231 cells, respectively. STAT3-IN-1 induces apoptosis of tumor cells.
S6784 STAT5-IN-1 STAT5-IN-1 is a potent and selective STAT5 inhibitor with IC50 of 47 μM for STAT5β isoform.
E2398 STAT5-IN-2 STAT5-IN-2 inhibits the growth of acute and chronic myeloid leukemia cells and the phosphorylation and transcriptional activity of STAT5, but not STAT3, AKT, or Erk1/2 phosphorylation, with minimal effects on bone marrow stromal cells that play vital functions in the microenvironment of hematopoietic and leukemic cells.
S7024 Stattic Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM in cell-free assays, highly selectivity over STAT1. Stattic induces apoptosis.
S1421 Staurosporine (AM-2282) Staurosporine (AM-2282, Antibiotic AM-2282, STS) is a potent PKC inhibitor for PKCα, PKCγ and PKCη with IC50 of 2 nM, 5 nM and 4 nM, less potent to PKCδ (20 nM), PKCε (73 nM) and little active to PKCζ (1086 nM) in cell-free assays. Also shows inhibitory activities on other kinases, such as PKA, PKG, S6K, CaMKII, etc. Phase 3.
S1398 Stavudine (d4T) Stavudine (d4T, BMY-27857, Sanilvudine, NSC 163661) is a nucleoside analog reverse transcriptase inhibitor (NARTI) active against HIV.
S5733 Stearic acid Stearic acid (Octadecanoic acid, Isostearic acid, Cetylacetic acid) is a natural saturated fatty acid found in animal and vegetable fats. It could be used as a food additive and used in soaps, cosmetics and detergents.
L9300 Stem Cell Differentiation Compound Library A unique collection of 249 stem cell differentiation related compounds used for high throughput screening(HTS) and high content screening(HCS).
L2100 Stem Cell Signaling Compound Library A unique collection of 870 compounds with biological activity used for stem cell regulatory and signaling pathway research.
E3040 Stemonae Extract
S2858 StemRegenin 1 (SR1) StemRegenin 1 (SR1) is an aryl hydrocarbon receptor (AhR) inhibitor with IC50 of 127 nM in a cell-free assay.
S8692 Stenabolic (SR9009) Stenabolic (SR9009) is a synthetic REV-ERB agonist with IC50s of 670 nM and 800 nM for REV-ERB-α and for REV-ERB-β, respectively.
S8419 Stenoparib (E7449) Stenoparib (E7449, 2X-121, MGI25036) is an orally bioavailable, brain penetrable, small molecule dual inhibitor of PARP1/2 and also inhibits PARP5a/5b, otherwise known as tankyrase1 and 2 (TNKS1/2), important regulators of canonical Wnt/β-catenin signaling. It has IC50 values of 1.0 and 1.2 nM for PARP1 and 2, respectively.
E3551 Stephania Extract
E3190 Stephaniae Tetrandrae Radix Extract
E3698 Stevia rebaudiana Extract
S3272 Steviol (Hydroxydehydrostevic acid) Steviol (Hydroxydehydrostevic acid, Hydroxy Dehydrostevic Acid, NSC 226902), a major metabolite of the sweetening compound stevioside, inhibits CFTR activity, reduces AQP2 expression and promotes AQP2 degradation.
S9226 Steviolbioside Steviolbioside (CCRIS-6025), a natural sweetener, exhibits moderate antituberculosis activity against M. tuberculosis strain H37RV in vitro.
S3805 Stevioside Stevioside is a natural sweetener extracted from leaves of Stevia rebaudiana (Bertoni) Bertoni.
S7931 STF-31 STF-31 is a selective glucose transporter GLUT1 inhibitor.
S1041 STF-62247 STF-62247 is a molecule targeting VHL-deficient renal cell carcinoma that induces autophagy. STF-62247 shows selective toxicity and growth inhibition of renal cells lacking VHL; 25-fold greater sensitivity observed for cells with VHL deficiency compared to wild-type (VHL+).
E2764 Stigmasta-4,22-dien-3-one

Stigmasta-4,22-dien-3-one (Stigmastadienone), a bioactive compound isolated from <i>Isodon rugosus</i>, has physiological effects on many targets.

S2361 Stigmasterol Stigmasterol is an unsaturated plant sterol that exhibits anti-cancer, anti-pyretic, anti-inflammatory and immune-modulating effects.
S8954 STING agonist-1 (G10) STING agonist-1 (G10) is a novel human-specific STING agonist that triggers IFN regulatory factor 3 (IRF3)/ type I interferon (IFN)-associated transcription in human fibroblasts. STING agonist-1 (G10) potently reduces growth of Chikungunya virus (CHIKV) with IC90 of 8.01 μM and blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV) with IC90 of 24.57 μM.
S6667 STING inhibitor C-178 C-178 is a covalent inhibitor of STING,covalently bind to Cys91.
S5266 Stiripentol Stiripentol (BCX2600) is a third-generation anti-epileptic drug that enhances GABAergic neurotransmission. It is an inhibitor of cytochrome P450.
E2396 STK16-IN-1 STK16-IN-1 is a serine/threonine protein kinase 16 (STK16) inhibitor with an IC50 of 295 nM.
E2523 STK414603
S9870 STM2457 STM2457 is a highly potent and selective first-in-class catalytic inhibitor of RNA Methyltransferase METTL3 with an IC50 of 16.9 nM. STM2457 is highly specific for METTL3 and showed no inhibition of other RNA methyltransferases.
S8274 STO-609 STO-609 is a specific inhibitor of the Ca2+/Calmodulin-dependent protein kinase kinase(CaM-KK) that inhibits the activities of recombinant CaM-KKα and CaM-KKβ isoforms, with Ki values of 80 and 15 ng/ml, respectively, and also inhibits their autophosphorylation activities. STO-609 inhibits AMPKK activity and inhibits autophagy.
S2572 Streptomycin sulfate Streptomycin sulfate is a sulfate salt of streptomycin that is a protein synthesis inhibitor.
S1312 Streptozotocin (STZ) Streptozotocin (STZ, NSC-85998, Streptozocin, U 9889) is a glucosamine-nitrosourea derivative, which is a DNA-methylating, carcinogenic, antibiotic and diabetes inducing agent. Streptozotocin induces autophagy and apoptosis. Solutions are best fresh-prepared.
E0205 Strictosamide Strictosamide is the main representative constituent of Nauclea officinalis Pierre ex Pitard (Rubiaceae) with anti-inflammatory and analgesic activities.
S2050 Strontium Ranelate Strontium Ranelate is a strontium(II) salt of ranelic acid for (-)-desmethoxyverapamil binding to calcium channel with IC50 of 0.5 mM.
E3461 Strychnos Extract
S3304 Stylopine Stylopine ((R,S)-Stylopine, Tetrahydrocoptisine) reduces nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), and the IL-6 production and cyclooxygenase-2 (COX-2) activity caused by the LPS stimulation. Stylopine is a major component of the leaf of Chelidonium majus L.
S9220 Stylopine hydrochloride Stylopine (Tetrahydrocoptisine, Coptisine), a major component of the leaf of Chelidonium majus L., is a protoberberine-type alkaloid that has potential biological activities, including anti-inflammatory activity.
S0227 SU 4313 SU 4313 is a bioactive chemical.
S0226 SU 4942 SU 4942 is a tyrosine kinase signal transduction modulator, targeting VEGF and ECGF.
S0228 SU 5201 SU 5201 (NSC 247030) is an interleukin-2 (IL-2) inhibitor.
S5988 SU-4984 SU-4984 is a cell-permeable, ATP-competitive and reversible inhibitor of the fibroblast growth factor receptor 1 (FGFR1).
S9905 SU0268 SU0268 is a potent and specific inhibitor of 8-Oxoguanine DNA glycosylase 1 (OGG1), with the IC50 of 0.059 μM.
S1080 SU11274 SU11274 (PKI-SU11274) is a selective Met (c-Met) inhibitor with IC50 of 10 nM in cell-free assays, no effects on PGDFRβ, EGFR or Tie2. SU11274 induces autophagy, apoptosis and cell cycle arrest.
S0504 SU14813 SU14813 (SU 014813) is a multiple receptor tyrosine kinase inhibitor with IC50 of 50 nM, 2 nM, 4 nM and 15 nM for VEGFR2, VEGFR1, PDGFRβ and Kit (c-Kit). SU14813 exhibits potent antiangiogenic and antitumor activity.
S6535 SU1498 SU1498, a powerful inhibitor of KDR (IC50 = 0.7 μM), stimulates accumulation of phosphorylated ERK1/2 in endothelial cells.
E2252 SU3327 SU3327 is a potent, selective and substrate-competitive c-Jun N-terminal kinase (JNK) inhibitor with an IC50 of 0.7 μM.
S0290 SU5204 SU5204 is a tyrosine kinase inhibitor with IC50 of 4 μM and 51.5 μM for FLK-1 (VEGFR-2) and HER2, respectively.
S6808 SU5205 SU5205 is an inhibitor of VEGF receptor 2 (VEGFR2/FLK-1) with IC50 of 9.6 µM.
S0291 SU5208 SU5208(3-[(Thien-2-yl)methylene]-2-indolinone) is an inhibitor of vascular endothelial growth factor receptor-2 (VEGFR2).
S6809 SU5214 SU5214 is a inhibitor of VEGF receptor 2 (VEGFR2/FLK-1) with IC50 of 14.8 µM and EGFR with IC50 of 36.7 µm, respectively.
S7667 SU5402 SU5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC50 of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGF-Rβ, respectively.
S6514 SU5408 SU5408 (VEGFR2 Kinase Inhibitor I) is a potent and selective inhibitor of VEGFR2 Kinase with IC50 of 70 nM.
S0278 SU5614 SU5614 (Chloro-SU5416, Chloro-Semaxanib) is a small molecule receptor tyrosine kinases (RTK) inhibitor of VEGFR-2, c-kit, and both wild-type and mutant FLT3. SU5614 reduces cell proliferation and induces apoptosis.
S7774 SU6656 SU 6656 is a selective Src family kinase inhibitor with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively.
S7636 SU9516 SU 9516 is a 3-substituted indolinone CDK inhibitor with IC50 of 22 nM, 40 nM, and 200 nM for CDK2, CDK1, and CDK4, respectively.
S8829 Subasumstat (TAK-981) Subasumstat (TAK-981) is a novel, selective inhibitor of the SUMOylation enzymatic cascade with potential immune-activating and antineoplastic activities.
E3328 Suberect spatholobus stem Extract
S5905 Suberohydroxamic acid Suberohydroxamic acid (suberic bishydroxamic acid) is a competitive HDAC inhibitor with IC50 values of 0.25 and 0.3 μM for HDAC1 and HDAC3 respectively.
E2184 Suberosin
E2070 Suberylarginine Suberylarginine is an arginine derivative of dicarboxylic acids isolated from the toad Bufo bufo venom, which can activate γ-aminobutyric acid type A receptor.
P1129 Substance P

Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).

S4692 Succimer Succimer (DMSA, meso-2,3-dimercaptosuccinic acid) is an orally active metal chelator is used to treat heavy metal poisoning.
S3791 Succinic acid Succinic acid (1,4-Butandioic Acid, 1,2-Ethanedicarboxylic acid, Amber acid, Asuccin, Butanedioic acid) is a crystalline organic acid which occurs in living tissue as an intermediate in glucose metabolism.
S0586 Succinic anhydride Succinic anhydride (SA, Succinyl Oxide, Butanedioic Anhydride) is a cyclic anhydride that can be used in the homogeneous chemical modification of cellulose and as a noncleavable ADC linker that reacts with other compound to link the prodrug to an amine or hydroxy 1 group of a targeting polypeptide.
S4121 Succinylcholine Chloride Dihydrate Succinylcholine Chloride Dihydrate (Suxamethonium) is a nicotinic AChR agonist and also acts as a depolarizing neuromuscular blocker.
S4585 Succinylsulfathiazole Succinylsulfathiazole (Succinylsulphathiazole), a sulfonamide, is an antibiotic.
S4670 Sucralfate Sucralfate is a sucrose sulfate-aluminium complex that binds to the ulcer, creating a physical barrier that protects the gastrointestinal tract from stomach acid and prevents the degradation of mucus.
S4214 Sucralose Sucralose (E955) is an artificial and noncaloric sweetener, not broken down by the body.
S3598 Sucrose Sucrose (D-(+)-Saccharose), a common sugar produced naturally in plants, is a disaccharide, a molecule composed of two monosaccharides:glucose and fructose.
S6191 Sudan I Sudan I (C.I. Solvent Yellow 14) is an azo dye. It causes tumors in the liver or urinary bladder in rats, mice, and rabbits and may be a potential carcinogen for humans.
S6240 Sudan II Sudan II (Sudan Red II, Solvent Orange 7, Color Index No: 12140, C.I. 12140) is a lysochrome (fat-soluble dye) azo dye used for staining of triglycerides in frozen sections, and some protein bound lipids and lipoproteins on paraffin sections.
S6460 Sugammadex (sodium) Sugammadex (ORG-25969) is a selective relaxant binding agent indicated for reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide during surgery in adults.
S1958 Sulbactam Sulbactam is a beta-lactamase inhibitor with an average IC50 of 0.8 μM.
S2551 Sulbactam sodium Sulbactam sodium (Unasyn, CP-45899-2) is an irreversible β-lactamase inhibitor.
S5333 Sulbenicillin Sodium Sulbenicillin Sodium (Sulfocillin, Sulfobenzylpenicillin) is the sodium salt of sulbenicillin, which is a penicillin antibiotic.
S5203 Sulbutiamine Sulbutiamine is a synthetic derivative of thiamine (vitamin B1), belonging to a class of supplements shown to help improve memory, learning capacity, decision-making, concentration, and focus.
S4120 Sulconazole Nitrate Sulconazole Nitrate is an imidazole derivative with broad-spectrum antifungal activity.
S4576 Sulfabenzamide Sulfabenzamide (Sultrin, N-Sulfanilylbenzamide) is an antibacterial/antimicrobial which also exhibit their antitumor effects through multiple mechanisms including inhibition of membrane bound carbonic anhydrases, prevention of microtubule assembly, cell cycle arrest, and inhibition of angiogenesis.
S5546 Sulfacetamide Sulfacetamide (Acetosulfamine) is a synthetic sulfanylacetamide derivative with bacteriostatic activity. It is an anti-infective agent that is used topically to treat skin infections and orally for urinary tract infections.
S4081 Sulfacetamide Sodium Sulfacetamide Sodium is an anti-biotic.
S4750 Sulfacetamide sodium salt hydrate Sulfacetamide is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase(DHPS) with IC50 of 9.5 μM. Sulfacetamide is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid.
S3708 Sulfachloropyridazine Sulfachloropyridazine is an antibiotic used to treat a variety of bacterial infections.
S1770 Sulfadiazine Sulfadiazine is a sulfonamide antibiotic.
S5096 SulfadiMethoxine sodium Sulfadimethoxine (Sulfadimethoxydiazine) is a long-lasting sulfonamide antimicrobial agent used to treat many infections including treatment of respiratory, urinary tract, enteric, and soft tissue infections.
S2511 Sulfadoxine Sulfadoxine (Sulphadoxine) is an ultra-long-lasting sulfonamide with an IC50 of 249 μg/ml for P. vivax.
S4175 Sulfaguanidine Sulfaguanidine is a sulfonamide used as an anti-infective agent.
S5291 sulfaisodimidine Sulfaisodimidine (Sulfamethin) is a sulfonamide antibacterial.
S4976 Sulfalene (SMPZ) Sulfalene (SMPZ, Butadiene sulfone, 3-Sulfolene) is a cyclic organic chemical used as a versatile synthetic intermediate.
S4898 Sulfalozine sodium Sulfalozine sodium (Sulfaclozine sodium, Sulfachlopryrazine sodium) is an antiprotozoal useful in coccidiosis research.
S3132 Sulfamerazine Sulfamerazine (RP 2632) is a sulfonamide antibacterial.
S1618 Sulfameter Sulfameter is a long-acting sulfonamide antibacterial.
S3133 Sulfamethazine Sulfamethazine is a sulfonamide antibacterial.
S5210 Sulfamethazine Sodium Salt Sulfamethazine (Sulfadimethyldiazine) is a sulfanilamide anti-infective agent used in the lifestock industry.
S1957 Sulfamethizole Sulfamethizole is a sulfathiazole antibacterial agent.
S1915 Sulfamethoxazole Sulfamethoxazole is a sulfonamide bacteriostatic antibiotic with an IC50 of 2.7 μM.
S4869 Sulfamethoxazole sodium Sulfamethoxazole sodium is an antibiotic used for bacterial infections.
S4250 Sulfamethoxypyridazine Sulfamethoxypyridazine (CL 13494) is a long-acting sulfonamide for treatment of Dermatitis herpetiformis.
S5606 Sulfamide Sulfamide (Sulfuric diamide) is used in organic chemistry for synthesis.
S3644 Sulfamonomethoxine Sulfamonomethoxine is a long-acting sulfonamide antibacterial agent and blocks the synthesis of folic acid by inhibiting synthetase of dihydropteroate.
S1685 Sulfanilamide Sulfanilamide (Sulphanilamide) is a competitive inhibitor for bacterial enzyme dihydropteroate synthetase with IC50 of 320 μM.
S3673 Sulfaphenazole Sulfaphenazole (Depocid, Depotsulfonamide, Plisulfan, Raziosulfa) is an inhibitor of CYP2C9 with Ki value of 0.3 μM and demonstrates at least 100-fold selectivity over other CYP450 isoforms (Ki values of 63 and 29 μM for CYP2C8 and CYP2C18, respectively, and no activity at CYP1A1, CYP1A2, CYP3A4, CYP2C19).
S1617 Sulfapyridine Sulfapyridine is a sulfonamide antibacterial.
S5031 Sulfaquinoxaline sodium Sulfaquinoxaline sodium (N'1-quinoxalin-2-ylsulphanilamide sodium, SQ-Na) is the sodium salt of sulfaquinoxaline, which is often used as a drug to prevent coccidiosis in poultry, swine, and sheep by inhibiting the synthesis of nucleic acids and proteins in microorganisms.
S1576 Sulfasalazine (NSC 667219) Sulfasalazine (NSC 667219, Azulfidine, Salazopyrin, Sulphasalazine) is a sulfa derivative of mesalazine, used as an anti-inflammatory agent to treat bowel disease and rheumatoid arthritis. Sulfasalazine is a potent and specific inhibitor of nuclear factor kappa B (NF-κB), TGF-β and COX-2. Sulfasalazine induces ferroptosis, apoptosis and autophagy.
S3116 Sulfathiazole Sulfathiazole is an organosulfur compound that has been used as a short-acting sulfa drug.
S5963 Sulfathiazole sodium Sulfathiazole sodium, an antimicrobial agent, is an organosulfur compound that has been used as a short-acting sulfa drug.
S0487 Sulfatinib Sulfatinib (HMPL-012, Sufatinib, Surfatinib, Surufatinib) is a potent and highly selective tyrosine kinase inhibitor against VEGFR1, VEGFR2, VEGFR3, FGFR1 and CSF1R with IC50 of 2 nM, 24 nM, 1 nM, 15 nM and 4 nM, respectively. Sulfatinib shows encouraging antitumor activity and manageable toxicities in patients with advanced NETs.
S1916 Sulfisoxazole Sulfisoxazole (NU-445) is a sulfonamide antibacterial with an oxazole substituent.
S0566 Sulfo-SMCC sodium Sulfo-SMCC sodium is a commonly-used hetero-bifunctional, noncleavable ADC crosslinker with N-hydroxysuccinimide (NHS) ester and maleimide groups to react with primary amines and sulfhydryl groups, respectively.
S4899 Sulfogaiacol Sulfogaiacol (Guaiacolsulfonate) is a antitussive agent that is used for acute respiratory tract infections, cough and other conditions.
S9782 Sulfopin

Sulfopin (PIN1-3) is a highly selective covalent inhibitor of Pin1 with a Ki of 17 nM in the FP assay. Sulfopin blocks Myc-driven tumor initiation and growth in vivo.

S5771 Sulforaphane Sulforaphane is a naturally occurring isothiocyanate derived from the consumption of cruciferous vegetables, such as broccoli, cabbage, and kale. It is an inducer of Nrf2. Sulforaphane is also an inhibitor of histone deacetylase (HDAC) and NF-κB. Sulforaphane increases heme oxygenase-1 (HO-1) and reduces the levels of reactive oxygen species (ROS). Sulforaphane induces cell cycle arrest and apoptosis.
S0974 Sulforaphene Sulforaphene promotes cancer cells apoptosis and inhibits migration via inhibiting EGFR, p-ERK1/2, NF‐κB and other signals. Sulforaphene exhibits inhibiting activity against velvetleaf seedlings. Sulforaphene is isolated from radish seeds.
E0366 Sulforhodamine 101 Sulforhodamine 101 (SR101) is a fluorescent dye and is widely used for astrocyte identification.
S5976 Sulforhodamine B sodium salt Sulforhodamine B (SRB, Acid Red 52, Kiton Red 620) sodium salt is a protein-specific fluorescent dye that is utilized to quantitate cell expansion, growth, and migration.
S2007 Sulindac Sulindac is a non-steroidal COX inhibitor, which potently inhibits prostaglandin synthesis, used in the treatment of acute or chronic inflammatory conditions.
S4652 Sulisobenzone Sulisobenzone (Benzophenone-4, Sungard) is an ingredient in some sunscreens which protects the skin from damage.
S5271 Suloctidil Suloctidil, a sulfur-containing aminoalcohol showing to inhibit human platelet aggregation, is a peripheral vasodilator and a potential antifungal agent.
S0879 Sulopenem Sulopenem (CP-70429) is an orally active, potent inhibitor of beta-lactamase. Sulopenem is a parenteral penem antibiotic with broad-spectrum activities against Gram-positive and Gram-negative bacteria.
S1962 Sulphadimethoxine Sulphadimethoxine is a non-reducing glucuronide.
S4655 Sulpiride Sulpiride (Dolmatil, Dobren, Sulpyrid, Aiglonyl, Dogmatil) is a dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid.
S5411 Sultamicillin Sultamicillin is a newly developed antibiotic in which ampicillin and the β-lactamase inhibitor sulbactam are linked as an ester.
S5406 Sultamicillin Tosylate Sultamicillin Tosylate is the tosylate salt of the double ester of sulbactam plus ampicillin. Sulbactam is a semisynthetic beta-lactamase inhibitor which, in combination with ampicillin, extends the antibacterial activity of the latter to include some beta-lactamase-producing strains of bacteria that would otherwise be resistant.
S1432 Sumatriptan Succinate Sumatriptan Succinate (GR 43175) is a triptan sulfa drug containing a sulfonamide group for the treatment of migraine headaches.
E3398 Sunflower dish Extract
S7781 Sunitinib (SU11248) Sunitinib (SU11248) is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit. Sunitinib is also a dose-dependent inhibitor of the autophosphorylation activity of IRE1α. Sunitinib induces autophagy and apoptosis.
S1042 Sunitinib (SU11248) malate Sunitinib (SU11248) malate is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM in cell-free assays, and also inhibits c-Kit. Sunitinib Malate effectively inhibits autophosphorylation of Ire1α. Sunitinib Malate increases both death receptor and mitochondrial-dependent apoptosis.
S8554 Super-TDU Super-TDU is an inhibitory peptide targeting YAP-TEADs interaction.
S2015 Suplatast Tosylate Suplatast Tosylate (IPD-1151T, Suplatast Tosilate) is a novel capsular anti-asthmatic agent that suppresses both IgE production, IL-4 and IL-5 synthesis with IC50 above 100 μM.
S1761 Suprofen Suprofen is a dual COX-1/COX-2 inhibitor, used as a non-steroidal anti-inflammatory analgesic and antipyretic.
S8942 Suramin sodium salt Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitive protein-tyrosine phosphatase (PTPases) inhibitor, also is the potent inhibitor of sirtuins, purified topoisomerase II and SARS-CoV-2 RNA-dependent RNA polymerase (RdRp).
E3791 Surgentodoxa Cuneata Extract
E3196 Suzuki Extract
S6747 SW-044248 SW-044248 is a non-canonical Top1 inhibitor with a pattern of selective toxicity for NSCLC cells.
E0792 SW-106065 SW-106065 is an apoptosis inducer in malignant peripheral nerve sheath tumors (MPNST), which can inhibit ATP consumption of sporadic MPNST and other models of MPNST with an EC50 of 1 µM.
S3438 SW155246 SW155246 is a potent and selective DNMT1 (DNA methyltransferase 1) inhibitor with IC50 of 1.2 μM. SW155246 induces re-expression of the tumor suppressor geneRASSF1 in A549 cells.
E3146 Sweet Potato Root Extract
E3763 Sweet Potatoes Extract
S9072 Sweroside Sweroside, a bioactive herbal ingredient isolated from Fructus Corni, exhibits diverse biological activities, such as anti-fungal, anti-diabetic, anti-inflammatory, and anti-tumor effects.
E3863 Swertia Bimaculata Extract
S3927 Swertiamarin Swertiamarin (Swertiamaroside) is a common secoiridoid found among the members of Gentianaceae with anti-inflammatory, anticancer, hypoglycemic and hypolipidemic activities.
E0910 Swertisin

Swertisin, a novel SGLT2 inhibitor, with improved glucose homeostasis for effective diabetes therapy.

E3881 Swine'S Gallbladder Extract
E3882 Swine'S Liver Extract Pig's liver Extract is extract from the liver of swine, a valuable edible slaughter by-products suitable for human consumption.
E3885 Swine‘S Pancreas Extract
S8947 SX-682 SX-682 is an orally bioavailable small-molecule allosteric inhibitor of CXCR1 and CXCR2 that blocks tumor MDSC recruitment and enhances T cell activation and antitumor immunity.
E3377 Symphytum officinale Extract
S2362 Synephrine Synephrine (Oxedrine), a natural protoalkaloid in the extract of bitter orange and other citrus species, is commonly used for weight loss.
S2438 Synephrine HCl SynephrineHCl (Oxedrine, p-Synephrine) is a sympathomimetic α-adrenergic receptor (AR) agonist.
S2937 SYP-5 SYP-5 is an inhibitor of Hypoxia-inducible factor-1 (HIF-1) that suppresses tumor cell migration and invasion, as well as tumor angiogenesis.
S4765 Syringaldehyde Syringaldehyde (Syringic aldehyde) is an organic compound that occurs naturally in trace amounts. It possesses worthy bioactive properties and is, therefore, used in pharmaceuticals, food, cosmetics, textiles, pulp and paper industries, and even in biological control applications. Syringaldehyde is a polyphenolic compound belonging to the group of flavonoids and is found in different plant species like Manihot esculenta and Magnolia officinalis. Syringaldehyde moderately inhibits COX-2 activity with an IC50 of 3.5 μg/mL[2]. Anti-hyperglycemic and anti-inflammatory activities.
E2338 Syringaresinol diglucoside

Syringaresinol diglucoside is a natural compound from bamboo leaves.

S0905 Syringaresnol-4-O-beta-D-apiofuranosy Syringaresnol-4-O-beta-D-apiofuranosy is a natrual product isolated from the bark of Albizzia myriophylla.
S3629 Syringic acid Syringic acid (NSC 2129, SYRA) is a potential antioxidant used in traditional Chinese medicine and is an emerging nutraceutical. It has potential anti-angiogenic, anti-glycating, anti-hyperglycaemic, neuroprotective, and memory-enhancing properties.
S9907 Syrosingopine (Su-3118) Syrosingopine (Su-3118) is a dual MCT1 and MCT4 inhibitor with IC50 values of 2500nM and 40 nM in HAP1 cells, respectively.
S9724 SZL P1-41 SZL P1-41 (compound #25) is a specific inhibitor of S-phase kinase-associated protein 2 (Skp2) that indeed binds to Skp2, prevents Skp2-Skp1 interaction and inhibits Skp2 SCF E3 ligase activity, which consequently suppresses survival of cancer cells and cancer stem cells. SZL P1-41 causes higher apoptosis rates in cancer cells.
E0038 [SER140]-PLP(139-151)

[SER140]-PLP(139-151) is a polypeptide fragment of the lipid protein of myelin.

S3999 α-santonin α-santonin, a naturally occurring sesquiterpene lactone, is a potent antiparasitic agent.
E2494 α-Spinasterol α-Spinasterol, isolated from Spinacia oleracea, has antibacterial activity, is a transient receptor potential vanilloid 1 (TRPV1) antagonist and has anti-inflammatory, antidepressant, antioxidant and antinociceptive effects.
S2273 β-Sitosterol β-Sitosterol (SKF 14463, 22,23-Dihydrostigmasterol) is one of several phytosterols (plant sterols) with chemical structures similar to that of cholesterol.
E2403 ζ-Stat (NSC37044) ζ-Stat (NSC37044) is a specific and atypical protein kinase Cζ (PKCζ) inhibitor, with an IC50 of 5 μM.