||(+)-(S)-Carvone, a monoterpene found mainly in caraway and dill seed oils, is used in cosmetic, food and pharmaceutical preparations.
||Sulfinpyrazone (G-28315, NSC 75925) is one of the most studied platelet COX inhibitors, also a uricosuric agent that competitively inhibits uric acid reabsorption in kidney proximal tubules.
||(-)-(S)-B-973B (B 973B, CS-2844) is a potent allosteric agonist with antinociceptive activity. (-)-(S)-B-973B is a positive allosteric modulator of α7 nAChR,.
||Sparteine Sulfate, a quinolizidine alkaloid, is the sulfate form of sparteini, which is a sodium channel blocker used as an oxytocic and an anti-arrhythmia agent.
||α-Pinene is found in the oils of many species of many coniferous trees, notably the pine and has insecticidal activity. (1S)-(-)-α-Pinene is a monoterpene and shows sleep enhancing property through a direct binding to GABAA-benzodiazepine (BZD) receptors by acting as a partial modulator at the BZD binding site.
||20(S)-Protopanaxadiol (PPD, 20-Epiprotopanaxadiol), the main intestinal metabolite of ginsenosides, is one of the active ingredients in ginseng. 20(S)-Protopanaxadiol inhibits P-glycoprotein in multidrug resistant cancer cells.
||(20S)-Protopanaxatriol (g-PPT, 20(S)-APPT), a neuroprotective metabolite of ginsenoside, protopanaxatriol (g-PPT), is a functional ligand for both GR and ERbeta and could modulate endothelial cell functions through the glucocorticoid receptor (GR) and estrogen receptor (ER).
(S)-(-)-1-Phenylethanol ((S)-1-Phenylethanol, (S)-(-)-Phenylethanol) is an enantiomer of 1-Phenylethanol with flavor properties.
||(S)-(−)-Limonene, a fragrance monoterpene mainly found in citrus peel oil, is also naturally occurs in the essential oils of herbs, tea tree oil, and turpentine oil.
||(S)-(−)-α-Methylbenzylamine is a chiral auxiliary in the enantiodivergent synthesis of simple isoquinoline alkaloids.
||(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor with potent anti-tumor activity.
||(S)-2-Hydroxy-3-phenylpropanoic acid (L-(-)-3-Phenyllactic acid, (2S)-2-Hydroxy-3-phenylpropanoic acid) is a valuable building block in the pharmaceutical and chemical industry—has recently emerged as an important monomer in the composition of the novel degradable biocompatible material of polyphenyllactic acid.
||(S)-2-Hydroxysuccinic acid (L-Malic acid), is a naturally occurring isomer of malic acid, found mainly in sour and unripe fruits.
||(S)-crizotinib, the (S)-enantiomer of crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM in a cell-free assay.
||(S)-Glutamic acid (L-Glutamic acid) is an endogenous, non-selective glutamate receptor agonist.
||Leucic acid ((S)-α-hydroxyisocaproic acid) is a metabolite of the branched chain amino acid known as leucine, which plays a significant role in the synthesis of muscle protein.
||(S)-Methoprene is a juvenile hormone analogue that prohibits the ability of the insect to change from pupae to adult.
||(S)-Methylisothiourea sulfate is a potent inhibitor of inducible NO synthase (iNOS).
||(S)-Viloxazine Hydrochloride is the S-isomer of Viloxazine, a selective norepinephrine reuptake inhibitor (NRI) that can be used as an antidepressant.
||(S,R,S)-AHPC (MDK7526, VH032-NH2, VHL ligand 1) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC is potential useful for the targeted degradation of the androgen receptor. (S,R,S)-AHPC can be connected to the ligand for protein such as BCR-ABL1 by a linker to form PROTACs such as GMB-475. GMB-475 induces the degradation of BCR-ABL1 with IC50 of 1.11 μM in Ba/F3 cells.
||(S,R,S)-AHPC hydrochloride (VH032-NH2, VHL ligand 1) is the VH032-based VHL ligand that is applicable to the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC hydrochloride can be connected to the ligand for protein by a linker to form PROTACs.
||(S,R,S)-AHPC-PEG4-NH2 hydrochloride (VH032-PEG4-NH2 hydrochloride, VHL Ligand-Linker Conjugates 4 hydrochloride, E3 ligase Ligand-Linker Conjugates 7) is a PROTAC E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker.
||20(S)-Ginsenoside Rh1 (Prosapogenin A2, Sanchinoside B2, Sanchinoside Rh1) is one of major bioactive compounds extracted from red ginseng, which has been increasingly used for enhancing cognition and physical health worldwide. It exhibits potent characteristics of anti-inflammatory, antioxidant, immunomodulatory effects, and positive effects on the nervous system. Ginsenoside Rh1 inhibits the expression of PPAR-γ, TNF-α, IL-6, and IL-1β.
||6-Shogaol, a naturally occuring product found in ginger, has anti-inflammatory and anticancer properties.
||S 38093 is a histamine H3 antagonist/inverse agonist with a moderate affinity for rat, mouse and human H3 receptors (Ki = 8.8, 1.44 and 1.2 μM, respectively) and no affinity for other histaminergic receptors.
||S(-)-Carbidopa is a peripheral decarboxylase inhibitor, used in combination with levodopa for treatment of Parkinsonism.
||(S)-(-)-Propranolol hydrochloride, the active enantiomer of propranolol, is a β-Adrenoceptor (β-Adrenergic Receptor) antagonist with log Kd values of -8.16, -9.08, and -6.93 for β1, β2, and β3, respectively.
||S-(+)-Ketoprofen (Compound 1, Actron, (S)-Ketoprofen, Dexketoprofen) is a potent inhibitor of cyclooxygenase (COX) with IC50 of 1.9 nM and 27 nM for COX-1 and COX-2, respectively.
||S-(+)-Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and anti-depressant activity in the central nervous system, less potent than its R enantiomer.
||S-(-)-Cotinine, a constituent of tobacco products and the major metabolite of nicotine, stimulates nicotinic receptors to evoke the release of DA in a calcium-dependent manner from superfused rat striatal slices.
||S-(4-Nitrobenzyl)-6-thioinosine (NBMPR, Nitrobenzylthioinosine, NBTI, NSC 296962) is an inhibitor of ENT1 transporter that crosses the blood-brain barrier and is able to potentiate the neuroprotective effects of adenosine.
||S-Adenosyl-L-homocysteine (SAH, S-Adenosylhomocysteine, AdoHcy, Formycinylhomocysteine) is an inhibitor for (Methyltransferase Like 3-14) METTL3-METTL14 heterodimer complex (METTL3-14) with IC50 of 0.9 μM.
||S-Allyl cysteine (SAC, S-Allylcysteine), a natural constituent of fresh garlic, has antioxidant and anticancer properties in animals. S-Allyl cysteine has an anticancer effect through the induction of apoptosis and a cell cycle arrest.
||S-Gboxin, a functional analogue of Gboxin, is an oxidative phosphorylation (OXPHOS) inhibitor which inhibits growth of mouse and human glioblastoma (GBM) with IC50 of 470 nM.
||S-Methyl-L-cysteine (S-Methylcysteine) is one of the identified number of bioactive substances in garlic that are water soluble that may exert some chemopreventive effects on chemical carcinogenesis.
||S-Ruxolitinib is the chirality of INCB018424, which is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3. Phase 3.
||S107 is a Type 1 ryanodine receptor (RyR1) stabilizer that binds RyR1 and enhances the binding affinity of calstabin-1.
||S107 hydrochloride is a specific stabilizer of RyR2 (type 2 ryanodine receptor)/FKBP12.6 (FK506 binding protein 12.6) complex that affects Ca2+ signaling.
S18-000003 is a potent, selective and orally active inhibitor of retinoic acid receptor-related orphan receptor-gamma-t (RORγt), with an IC50 of <30 nM towards human RORγt in competitive binding assays.
||S1RA (E-52862) is a selective sigma-1 receptor (σ1R) antagonist with a reported binding affinity of Ki = 17.0 ± 7.0 nM for human σ1 receptor , selective over the sigma-2 receptor and against a panel of other 170 receptors, enzymes, transporters and ion channels.
||S3I-201 (NSC 74859) shows potent inhibition of STAT3 DNA-binding activity with IC50 of 86 μM in cell-free assays, and low activity towards STAT1 and STAT5.
||S49076 is a novel, potent inhibitor of Met (c-Met), AXL/MER, and FGFR1/2/3 with IC50 values below 20 nmol/L.
||S55746 (S 055746,BCL201) is a novel, orally active BCL-2 specific inhibitor (Ki = 1.3 nM) with poor affinity for BCL-XL and no significant binding to MCL-1, BFL-1 (BCL2A1/A1). The selectivity of S55746 for BCL-2 versus BCL-XL ranges from ~70 to 400 folds.
||S63845 is a new, selective MCL-1 inhibitor with the Kd value of 0.19 nM and has no discernible binding to the other BCL-2 members, BCL-2 or BCL-XL.
||S64315 (MIK665) is an inhibitor of induced myeloid leukemia cell differentiation protein Mcl-1 with Ki value of 1.2 nM and has potential pro-apoptotic and antineoplastic activities.
||S6K-18 is a highly selective inhibitor of ribosomal protein S6 kinase beta-1 (S6K1, p70S6K, p70-S6K).
||S6K1 Rabbit Recombinant mAb
||S6K1 Rabbit Recombinant mAb detects endogenous level of total S6K1.
||S961 is a biosynthetic insulin receptor antagonist that inhibits cellular proliferation and colony formation in breast tumour cells.
||Sabutoclax (BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively.
||Saccharin (Benzoic sulfimide, O-Sulfobenzimide, O-Benzoic sulfimide, Saccharimide) is an artificial sweetener with effectively no food energy.
||Saccharin 1-methylimidazole (SMI)
||Saccharin 1-methylimidazole (SMI) is considered a general-purpose activator for DNA and RNA synthesis.
||Saccharin sodium salt hydrate
||Saccharin (O-Sulfobenzimide, O-Benzoic sulfimide, Saccharimide) is an artificial sweetener with effectively no food energy.
||Sacituzumab (anti-Trop-2) is a fully humanized IgG1 kappa monoclonal antibody that binds Trop-2.
||Sacubitril hemicalcium salt
||Sacubitril (AHU-377) hemicalcium salt, a component of the heart failure medicine LCZ696, is a potent inhibitor of neprilysin (neutral endopeptidase, NEP).
||Sacubitril/valsartan (LCZ696, Sacubitril, Valsartan), consisting of valsartan and sacubitril in 1:1 molar ratio, is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and heart failure. Phase 3.
||Sacubitrilat (Sac, LBQ-657) is an active inhibitor of neprilysin (NEP).
||Safflower Yellow (Safflor Yellow, SY), the main active constituent of the traditional Chinese medicine Safflower, is known as a neuroprotective agent that indirectly attenuates neuroinflammation.
||Safinamide (EMD-1195686, PNU-15774E) is an orally active, selective, reversible monoamine oxidase-B inhibitor with both dopaminergic and non-dopaminergic (glutamatergic) properties. The IC50 value of safinamide for MAO-B is 98 nM.
||Safinamide Mesylate (PNU-151774E, FCE28073) is mesylate salt of Safinamide, selectively and reversibly inhibits MAO-B with IC50 of 98 nM, exhibits 5918-fold selectivity against MAO-A. Phase 3.
||Saikosaponin A is a triterpene saponin derived from the medicinal plant, Bupleurum chinensis DC. (Umbelliferae). It has a variety of pharmacological benefits, including anti-inﬂammatory, immunomodulatory, and anti-bacterial activities.
||Saikosaponin B2 is a naturally occurring terpenoid that efficiently inhibits hepatitis C virus entry.
||Saikosaponin C is a triterpene saponin found in Bupleurum that exhibits antiviral and pro-angiogenic activities.
||Saikosaponin D, a calcium mobilizing agent (SERCA inhibitor), is a type of Saponin derivative, which is a component extracted from Bupleurum falactum. Saikosaponin D has anti-cancer activities.
||Sakuranetin is a rice flavonoid phytoalexin that shows antifungal activity. Sakuranetin has anti-inflammatory and antioxidative activities. Sakuranetin ameliorates LPS-induced acute lung injury.
||Salbutamol (Albuterol) is a short-acting, selective beta2-adrenergic receptor agonist used to treat or prevent bronchospasm in patients with asthma, bronchitis, emphysema, and other lung diseases.
||Salbutamol Sulfate (Albuterol) is a short-acting β2-adrenergic receptor agonist with an IC50 of 8.93 µM.
||Salicin (Salicoside, Salicine) is a phenol β-glycosid produced from willow bark that shows anti-inflammatory effects. It is a natural, non-selective COX-1 and COX-2 inhibitor.
||Salicylamide (o-hydroxybenzamide) is a non-prescription drug with analgesic and antipyretic properties.
||Salicylanilides (WR10019) are a group of compounds with a wide range of biological activities including antiviral potency, antibacterial (including antimycobacterial) and antifungal activities.
||Salicylic acid (2-Hydroxybenzoic acid) is a beta hydroxy acid that occurs as a natural compound in plants which is an inhibitor of ethylene biosynthesis and cyclooxygenase activity.
||Salidroside (Rhodioloside), a phenylpropanoid glycoside isolated from Rhodiola rosea, has been reported to have a broad spectrum of pharmacological properties. Salidroside is a prolyl endopeptidase inhibitor. Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling. Salidroside protects dopaminergic neurons by enhancing PINK1/Parkin-mediated mitophagy.
||Salifungin (Multifungin, Bromosalicylchloranilide) is an antifungal and may cause allergic contact dermatitis in some individuals.
||Salinomycin (from Streptomyces albus)
||Salinomycin (Coxistac, Bio-cox, Procoxacin), traditionally used as an anti-coccidial drug, has recently been shown to possess anti-cancer and anti-cancer stem cell (CSC) effects.
||Salinosporamide A (NPI-0052)
||Salinosporamide A (NPI-0052, ML858, Marizomib, MRZ) is a novel marine derived proteasome inhibitor which inhibits CT-L β5, C-L β1, and T-L β2 proteasome activities in human erythrocyte-derived 20S proteasomes with IC50 of 3.5 nM, 430 nM, 28 nM.
||Salirasib (Farnesylthiosalicylic acid, FTS) is a potent competitive prenylated protein methyltransferase (PPMTase) inhibitor with Ki of 2.6 μM, which inhibits Ras methylation. Salirasib exerts antitumor effects and induces autophagy. Salirasib exerts antitumor effects and induces autophagy. Phase 2.
||Salmeterol (Astmerole, GR-33343X, SN408D) is a long-acting beta2-adrenergic receptor agonist with Ki value of 1.5 nM for WT β2AR and shows very high selectivity for the WT β2AR(β1Ki/β2Ki ratio of approximately 1500).
||Salmeterol Xinafoate is a long-acting β2-adrenergic receptor agonist with anti-inflammatory effects, used in the treatment of asthma symptoms and chronic obstructive pulmonary disease (COPD) symptoms.
||Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM in a cell-free assay.
||Salvianolic acid A
||Salvianolic acid A (Dan Phenolic Acid A), a water-soluble compound extracted from Radix Salvia miltiorrhiza (Danshen), is an antioxidant and free radical scavenging compound that also acts as an inhibitor of the protein-protein interaction mediated by SH2 domains of Src-family kinases Src and Lck.
||Salvianolic acid B
||Salvianolic acid B (Sal B, Lithospermate B, Lithospermic acid B), an antioxidant and free radical scavenging compound, is the most abundant bioactive compound extracted from the root of Salvia miltiorrhiza Bunge.
||Salvianolic acid C
||Salvianolic acid C is a moderate mixed, noncompetitive inhibitor of Cytochrome P4502C8 (CYP2C8) and Cytochrome P45022J2 (CYP2J2) with Ki of 4.82 μM and 5.75 μM for CYP2C8 and CYP2J2, respectively.
||Samotolisib (LY3023414, GTPL8918) is an oral ATP competitive inhibitor of the class I PI3K isoforms, mTOR and DNA-PK.
||Samuraciclib (ICEC0942, CT7001) is a new, orally bioavailable CDK7 inhibitor with an IC50 of 40nM. The IC50 values for CDK1, CDK2, CDK5 and CDK9 were 45-, 15-, 230- and 30-fold higher. ICEC0942 (CT7001) promotes cell cycle arrest and apoptosis.
||Sancycline (Bonomycin, Norcycline, GS 2147) is a semi-synthetic tetracycline antibiotic.
||Sanguinarine (Pseudochelerythrine, Sanguinarin, Sanguinarium), a benzophenanthridine alkaloid known as an anti-inflammatory agent, is a potent inhibitor of NF-κB activation.
||Sanguinarine, a plant alkaloid, is a potent and specific protein phosphatase (PP) 2C inhibitor. Sanguinarine chloride can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.
||Santalol is a naturally occuring sesquiterpene that has antibacterial, anti-hyperglycaemic, anti inflammatory and antioxidant effects.
||Sapanisertib (MLN0128, INK 128, TAK-228) is a potent and selective mTOR inhibitor with IC50 of 1 nM in cell-free assays; >200-fold less potent to class I PI3K isoforms, superior in blocking mTORC1/2 and sensitive to pro-invasion genes (vs Rapamycin). Phase 1.
||Sapitinib (AZD8931) is a reversible, ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 with IC50 of 4 nM, 3 nM and 4 nM in cell-free assays, more potent than Gefitinib or Lapatinib against NSCLC cell, 100-fold more selective for the ErbB family than MNK1 and Flt. Phase 2.
||Sapogenins glycosides (Saponins) are a mixture of triterpene and steroid saponins isolated from medicinal plants such as Aesculus hippocastanum L., Hedera helix L. and Ruscus aculeatus L., which are claimed to be effective for the treatment/prevention of venous insufficiency.
||Sapropterin Dihydrochloride (Tetrahydrobiopterin, R-THBP), a synthetic preparation of the dihydrochloride salt of naturally occurring tetrahydrobiopterin (BH4), is a phenylalanine hydroxylase activator.
||Saquinavir (Ro 31-8959)
||Saquinavir (Ro 31-8959) is a potent and selective inhibitor of HIV proteinase with a mean IC50 of 2.7 nM in JM cells.
||SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor with an IC50 of 13.3 nM.
||SAR-20347 is a potent inhibitor of TYK2, JAK1, JAK2 and JAK3 with IC50 of 0.6 nM, 23 nM, 26 nM and 41 nM, respectively. SAR-20347 inhibits TYK2- and JAK1-mediated IL-12 and IFN-α signaling.
||SAR125844 is a potent intravenously active and highly selective Met (c-Met) kinase inhibitor, displaying nanomolar activity against the wild-type kinase (IC50 value of 4.2 nmol/L) and H1094Y, Y1235D, M1250T, L1195V, and D1228H kinase domain mutants (IC50 values of 0.22, 1.7, 6.5, 65, and 81 nmol/L, respectively).
||SAR131675 is a VEGFR3 inhibitor with IC50/Ki of 23 nM/12 nM in cell-free assays, about 50- and 10-fold more selective for VEGFR3 than VEGFR1/2, little activity against Akt1, CDKs, PLK1, EGFR, IGF-1R, c-Met, Flt2 etc.
||SAR405 is a low-molecular-mass kinase inhibitor of PIK3C3/Vps34 (KD 1.5 nM) showing high selectivity and not be active up to 10 μM on class I and class II PI3Ks as well as on mTOR. SAR405 prevents autophagy and synergizes with MTOR (mechanistic target of rapamycin) inhibition in tumor cells.
||SAR405 R enantiomer
||SAR405 R enantiomer is the less active enantiomer of SAR405 which is an inhibitor of PIK3C3/Vps34.
||SAR7334 is a novel, highly potent and bioavailable inhibitor of TRPC6 channels.SAR7334 blocks TRPC6 currents with an IC50 of 7.9 nM in patch-clamp experiment.
||Saracatinib (AZD0530) is a potent Src inhibitor with IC50 of 2.7 nM in cell-free assays, and potent to c-Yes, Fyn, Lyn, Blk, Fgr and Lck; less active for Abl and EGFR (L858R and L861Q). Saracatinib induces autophagy. Phase 2/3.
||Sarafloxacin HCl (A-56620) is a hydrochloride salt form of sarafloxacin which is a quinolone antibiotic drug with IC50 of 0.96 μg/L.
||Sarcosine (N-methylglycine, Sarcosinic acid, Methylaminoacetic acid, Methylglycine) is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist.
||Sarecycline (P005672) hydrochloride (HCl) is a narrow-spectrum tetracycline-class antibiotic that possesses anti-inflammatory properties and potent activity against Gram-positive bacteria. Sarecycline hydrochloride interferes with tRNA accommodation and tethers mRNA to the 70S ribosome.
||Sarilumab (anti-IL-6Rα) is a fully human anti-IL-6Rα mAb that binds membrane-bound and soluble human IL-6Rα with high affinity, MW: 144.13 KD.
||Saroglitazar (Lipaglyn, ZYH1) is an agonist of peroxisome proliferator-activated receptor (PPAR) with EC50 of 0.65 pM and 3 nM for hPPARα and hPPARγ in HepG2 cells, respectively.
||Sarpogrelate (MCI-9042) is a selective 5-HT2A antagonist with pKi values of 8.52, 7.43 and 6.57 for 5-HT2A, 5-HT2C and 5-HT2B receptors respectively.
||Sarsasapogenin (SAR, Parigenin) is a steroidal sapogenin. It can provoke the generation of reactive oxygen species and activate unfolded protein response (UPR) signaling pathways. SAR potently inhibits NF-κB and MAPK activation, as well as IRAK1, TAK1, and IκBα phosphorylation in LPS-stimulated macrophages.
||Sasapyrine (Salsalate, NSC-49171) is a nonsteroidal oral anti-inflammatory agent.
||Savolitinib (Volitinib, AZD6094, HMPL-504) is a novel, potent, and selective MET inhibitor currently in clinical development in various indications, including PRCC. The IC50 values of this compound for c-Met and p-Met are 5 nM and 3 nM, respectively. It shows exquisite selectivity for c-Met over 274 kinase.
||Saxagliptin (BMS-477118, Onglyza) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.
||Saxagliptin H2O (BMS-477118, Onglyza) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.
||SB 200646 (SB 200646A) is a potent, selective and oral-active antagonist of 5-HT2B/2C over 5-HT2A receptor with 50 fold selectivity. The pKi for rat 5-HT2C receptor, rat 5-HT2B receptor and rat 5-HT2A receptor are 6.9, 7.5 and 5.2, respectively. SB 200646 has electrophysiological and anxiolytic properties in vivo.
||SB265610, a competitive antagonist at the human CXCR2 receptor, can displace [125I]-IL-8 and [125I]-GROα with pIC50 values of 8.41 and 8.47 respectively, preventing receptor activation by binding to a region distinct from the agonist binding site.
||SB 271046 hydrochloride
||SB 271046 hydrochloride is a potent, selective and orally active 5-HT6 receptor antagonist with pKi of 8.9, exhibits 200-fold greater selectivity over other 5-HT receptor subtypes.
||SB 4 (Eticovo)
||SB 4 (Eticovo) is a potent and selective agonist of bone morphogenetic protein 4 (BMP4) signaling with EC50 of 74 nM. SB 4 (Eticovo) enhances canonical BMP signaling and activates SMAD-1/5/9 phosphorylation.
||SB-200646A is an orally active, selective antagonist of 5-HT2B/2C over 5-HT2A receptor with pKi of 7.5, 6.9 and 5.2 for 5-HT2B, 5-HT2C and 5-HT2A, respectively. SB-200646A exerts electrophysiological and anxiolytic properties in vivo.
||SB-297006 is an antagonist of C-C chemokine receptor 3 (CCR3) that suppresses antigen-induced accumulation of T(h)2 as well as eosinophils in the lungs. SB-297006 suppressed CCL11-induced Th2 chemotaxis with IC50 of 2.5 μM.
||SB-334867 is a selective orexin-1 (OX1) receptor antagonist.
||SB-3CT is an effective and selective gelatinase inhibitor with Ki of 13.9 nM and 600 nM for MMP-2 and MMP-9, respectively.
||SB-756050 is a selective TGR5 agonist (EC50 = 1.3 μM for the human receptor).
||SB202190 (FHPI) is a potent p38 MAPK inhibitor targeting p38α/β with IC50 of 50 nM/100 nM in cell-free assays, sometimes used instead of SB 203580 to investigate potential roles for SAPK2a/p38 in vivo. SB202190 inhibits endothelial cell apoptosis via induction of autophagy and heme oxygenase-1. SB202190 significantly suppresses Erastin‐dependent ferroptosis.
||SB216763 is a potent and selective GSK-3 inhibitor with IC50 of 34.3 nM for GSK-3α and equally effective at inhibiting human GSK-3β. SB216763 activates autophagy.
||SB225002 is a potent, and selective CXCR2 antagonist with IC50 of 22 nM for inhibiting interleukin IL-8 binding to CXCR2, > 150-fold selectivity over the other 7-TMRs tested.
||SB239063 is a potent and selective p38 MAPKα/β inhibitor with IC50 of 44 nM, showing no activity against the γ- and δ-kinase isoforms.
||SB269970 HCl is a hydrochloride salt form of SB-269970, which is a 5-HT7 receptor antagonist with pKi of 8.3, exhibits >50-fold selectivity against other receptors.
||SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively.
||SB290157 trifluoroacetate (SB 290157 TFA) is a potent, competitive and selective antagonist of C3a receptor (C3aR) with IC50 of 200 nM for RBL-C3aR.
||SB-366791 is a novel, potent, and selective, cinnamide TRPV1 antagonist with an IC50 of 5.7 nM.
||SB415286 is a potent GSK3α inhibitor with IC50/Ki of 78 nM/31 nM with equally effective inhibition of GSK-3β. SB415286 causes MM cell growth arrest and apoptosis.
||SB431542 is a potent and selective inhibitor of ALK5 with IC50 of 94 nM in a cell-free assay, 100-fold more selective for ALK5 than p38 MAPK and other kinases.
||SB505124 is a selective inhibitor of TGFβR for ALK4, ALK5 with IC50 of 129 nM and 47 nM in cell-free assays, respectively, also inhibits ALK7, but does not inhibit ALK1, 2, 3, or 6.
||SB525334 is a potent and selective inhibitor of TGFβ receptor I (ALK5) with IC50 of 14.3 nM in a cell-free assay, 4-fold less potent to ALK4 than ALK5 and inactive to ALK2, 3, and 6.
||SB590885 is a potent B-Raf inhibitor with Ki of 0.16 nM in a cell-free assay, 11-fold greater selectivity for B-Raf over c-Raf, no inhibition to other human kinases.
||SB705498 is a TRPV1 antagonist for hTRPV1, antagonizes capsaicin, acid, and heat activation of TRPV1 with IC50 of 3 nM, 0.1 nM and 6 nM, shows a degree of voltage dependence, exhibits >100-fold selectivity for TRPV1 over TRPM8. Phase 2.
||SB742457 (GSK 742457) is a highly selective 5-HT6 receptor antagonist with pKi of 9.63, exhibits >100-fold selectivity over other receptors. Phase 2.
||SB743921 is a kinesin spindle protein (KSP) inhibitor with Ki of 0.1 nM, almost no affinity to MKLP1, Kin2, Kif1A, Kif15, KHC, Kif4 and CENP-E. Phase 1/2.
||SBC-110736 is an inhibitor of proprotein convertase subtilisin kexin type 9 (PCSK9) that lowers cholesterol levels in mice.
||SBC-115076 is a potent extracellular proprotein convertase subtilisin kexin type 9 (PCSK9) antagonist.
SBC-115337 is a PCSK9 inhibitor with an IC50 value of 0.5 μM.
SBFI-26 competitively inhibits the activities of FABP5 and FABP7.
||SBI-0206965 is a highly selective autophagy kinase ULK1 inhibitor with IC50 of 108 nM, about 7-fold selectivity over ULK2. SBI-0206965 inhibits autophagy and enhances apoptosis in human glioblastoma and lung cancer cells.
||SBI-0640756 is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex. It can also suppress AKT and NF-kB signaling.
||SBI-115 is a novel TGR5 (GPCR19) antagonist. SBI-115 decreases cell proliferation, cholangiocyte spheroid growth and cAMP levels in cystic cholangiocytes.
||SBI-477 is an insulin signaling inhibitor that deactivates the transcription factor MondoA, leading to reduced expression of the insulin pathway suppressors thioredoxin-interacting protein (TXNIP) and arrestin domain-containing 4 (ARRDC4). SBI-477 inhibits triacylglyceride (TAG) synthesis and enhances basal glucose uptake in human skeletal myocytes.
||SBI-553 is a potent, brain-penetrant and allosteric modulator of NTR1 with EC50 of 0.34 μM.
||SBI-797812 is a NAMPT activator which is structurally similar to active-site directed NAMPT inhibitors and blocks binding of these inhibitors to NAMPT. SBI-797812 turns NAMPT into a "super catalyst" that more efficiently generates NMN.
||SBP-7455 is a dual-Specific ULK1/2 autophagy inhibitor with IC50s of 13 nM and 476 nM for ULK1 and ULK2 in ADP-Glo assay, respectively.
||SC 236 is a selective COX-2 inhibitor with IC50 of 0.005 μM and 17.8 μM for COX-2 and COX-1, respectively. SC 236 displays anti-inflammatory properties and potent antimetastatic activity against both experimental metastases and spontaneous metastases arising following primary tumor excision.
||SC-1 blocks STAT3 phosphorylation and activation, and induces apoptosis in hepatocellular carcinoma cell lines. SC-1 is a derivative of the multiple tyrosine kinase inhibitor sorafenib.
||SC-26196 is a potent, orally active inhibitor of Delta6 desaturase (D6D) with IC50 of 0.2 µM in a rat liver microsomal assay. SC-26196 has anti-inflammatory properties.
||SC-43, a sorafenib derivative, is an agonist of Src-homology protein tyrosine phosphatase-1 (SHP-1/PTPN6) and reduces liver fibrosis. SC-43 reduces p-STAT3 and induces apoptosis with anti-tumor activity.
||SC-514 (GK 01140) is an orally active, ATP-competitive IKK-2 inhibitor with IC50 of 3-12 μM, blocks NF-κB-dependent gene expression, does not inhibit other IKK isoforms or other serine-threonine and tyrosine kinases.
||SC-560 is a highly selective COX-1 inhibitor with IC50 of 9 nM, compared with the IC50 of 6.3 μM for COX-2, nearly 1,000-fold higher than with COX-1.
||SC-57461A is an inhibitor of leukotriene A4 hydrolase (LTA4H).
||SC75741 is a potent NF-κB inhibitor with EC50 of 200 nM. SC75741 efficiently blocks influenza virus propagation.
||SC79 is a brain-penetrable Akt phosphorylation activator and an inhibitor of Akt-PH domain translocation.
||SC99 is an orally active, selective inhibitor of STAT3 that docks into the ATP-binding pocket of JAK2 and inhibits phosphorylation of JAK2 and STAT3. SC99 inhibits platelet activation, aggregation and displays potent anti-myeloma, anti-thrombotic activities.
||SCARB1 Rabbit Recombinant mAb
||SCARB1 Rabbit Recombinant mAb detects endogenous level of SCARB1.
||Scarlet 808 is a chemical dye.
||SCH-23390 hydrochloride (R-(+)-SCH-23390, SCH-23390) is a highly potent and selective dopamine D1-like receptor antagonist with Ki of 0.2 nM and 0.3 nM for the D1 and D5 dopamine receptor subtypes, respectively. SCH-23390 hydrochloride is a potent and high efficacy agonist at h5-HT2C receptors with Ki of 9.3 nM. SCH-23390 hydrochloride directly inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with IC50 of 268 nM.
||SCH-442416 is a selective antagonist of adenosine A2A receptor that binds to human and rat adenosine A2A receptors with Ki of 0.048 nM and 0.5 nM, respectively.
SCH 54292 is a potent Ras-GEF interaction inhibitor with IC50 of 0.7 uM.
||SCH 58261 is a potent and selective A2a adenosine receptor antagonist with Ki of 2.3 nM and 2 nM for rat A2a and bovine A2a, respectively.
||SCH772984 is a novel, specific inhibitor of ERK1/2 with IC50 values of 4 nM and 1 nM in cell-free assay, respectively, And show robust efficacy in RAS- or BRAF-mutant cancer cells.
||Schaftoside, a bioactive compound found in the Herba Desmodii Styracifolii, exhibits pancreatic lipase inhibitory activity. Schaftoside inhibits the expression of TLR4 and Myd88. Schaftoside also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission.
||Schisandrin A (Sch A, Deoxyschizandrin, Wuweizisu A) is an active component of Schisandrae Fructus with liver-protective, antitumor, and antioxidant activities. It is an agonist of the adiponectin receptor 2 (AdipoR2) with the IC50 value of 3.5 μM.
||Schisandrin B (Sch B)
||Schisandrin B is the most abundant dibenzocyclooctadiene lignan present in the traditional Chinese medicinal herb Schisandra chinensis (Turcz.) Baill. It is a kind of ATR and P-gp inhibitor with high safety.
||Schisanhenol (Gomisin K3) is a compound derived from the fruit of a traditional Chinese herb Schisandra rubriflora, exhibiting strong inhibition toward UGT2B7.
||Schisantherin A (Gomisin C, Schisanwilsonin H, Arisanschinin K) is a dibenzocyclooctadiene that exhibits anti-tussive, sedative, anti-inflammatory, anti-osteoporotic, neuroprotective, cognition enhancing, and cardioprotective activities. Schisantherin A inhibits p65-NF-κB translocation into the nucleus by IκBα degradation.
||Schisantherin B (Gomisin-B, Wuweizi ester-B) is one bioactive of lignans isolated from Schisandra chinensis (Turcz.) Baill which has been commonly used as a traditional herbal medicine.
||Schizandrol A is one of the effective components in the dried fruit of Schizandra chinensis Bail and works by increasing dopamine, a neurotransmitter, in the brain.
||Schizandrol B (Gomisin A, Besigomsin, Wuweizi alcohol B, Gamma-Schisandrin), extracted from the fruit of Schisandra chinensis Baill., exhibits potent antitumor activities.
||Sciadopitysi inhibits NF-κB activation and reduces the expression of c-Fos and NFATc1, thus inhibiting RANKL-induced osteoclastogenesis and bone loss. Sciadopitysin is a type of biflavonoids in leaves from ginkgo biloba.
||Sclareol, a labdane-type diterpene isolated from clary sage (Salvia sclarea), exerts growth inhibition and cytotoxic activity against a variety of human cancer cell lines.
||Sclareolide (Norambreinolide) is a sesquiterpene lactone natural product derived from various plant sources including Salvia sclarea, Salvia yosgadensis, and cigar tobacco.
||Scoparone (6,7-dimethoxycoumarin, Aesculetin dimethyl ether, 6,7-Dimethylesculetin, Escoparone) is a natural organic compound discovered from Chinese herb Artemisia scoparia with anticoagulant, hypolipidemic, vasorelaxant, antioxidant, and anti-inflammatory actions.
||Scopine is the metabolite of anisodine, which is a α1-adrenergic receptor agonist and used in the treatment of acute circulatory shock.
||Scopolamine (Skopolamin) is a tropane alkaloid derived from plants of the nightshade family, specifically Hyoscyamus niger and Atropa belladonna, with anticholinergic, antiemetic and antivertigo properties.
||Scopolamine (LSM-4015) HBr
||Scopolamine HBr (LSM-4015, NSC 61806) is a competitive muscarinic acetylcholine receptor antagonist with an IC50 of 55.3 nM.
||Scopolamine HBr trihydrate
||Scopolamine HBr is a competitive muscarinic acetylcholine receptor antagonist with an IC50 of 55.3 nM.
||Scopolamine N-Oxide HydrobroMide Monohydrate
||Scopolamine N-Oxide (Hyoscine N-oxide, Genoscopolamine) is a muscarinic antagonist used to study binding characteristics of muscarinic cholinergic receptors.
||Scopoletin (Esculetin 6-methyl ether, Gelseminic acid, 6-Methylesculetin, Chrysatropic acid) is the main bioactive constituent of flower buds from Magnolia fargesii with anti-inflammatory, hypouricemic, and antioxidant activities.
||Scopoletin acetate is a coumarin isolated from the herbs of Atropa belladonna L.
||Scopolin, a coumarin isolated from Arabidopsis thaliana (Arabidopsis), attenuates hepatic steatosis through activation of SIRT1-mediated signaling cascades, a potent regulator of lipid homeostasis.
||SCR-1481B1 (c-Met inhibitor 2) is a potent activator of Met and an inhibitor of VEGFR. SCR-1481B1 exhibits anti-cancer activity.
||SCR130 is a novel DNA repair inhibitor with IC50s of 14 μM in Reh cells and 2 μM in Nalm6 cells. SCR130 specifically inhibits DNA Ligase IV‐mediated joining with minimal or no effect on Ligase III and Ligase I mediated joining.
||Scriptaid (GCK 1026) is an inhibitor of HDAC. It shows a greater effect on acetylated H4 than H3.
||Scutellarein (6-Hydroxyapigenin), extracted from the perennial herb Scutellaria lateriflora, has antioxidant, antitumor, anti-adipogenic, antiviral and anti-inflammatory activities
||Scutellarein tetramethyl ether
||Scutellarein tetramethyl ether (Tetra-O-methylscutellarein, 4',5,6,7-Tetramethoxyflavone), a bioactive component of Siam weed extract, exhibits anti-inflammatory activity through NF-κB pathway. Scutellarein tetramethyl ether modulats bacterial drug resistance via efflux pump inhibition and can enhance blood coagulation.
||Scutellarin (Breviscapine, Breviscapin, Scutellarein-7-glucuronide), the major active principal flavonoids extracted from the Chinese herbal medicines Scutellaria baicalensis and Erigeron breviscapus (Vant.) Hand-Mazz, has many pharmacological effects, such as antioxidant, antitumor, antiviral, and antiinflammatory activities. Scutellarin can down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts.
||Scyllo-Inositol (Scyllitol, Cocositol, Quercinitol, AZD 103, Scyllo-Cyclohexanehexol) is a naturally occurring plant sugar alcohol found most abundantly in the coconut palm.
||SD0006 is an inhibitor of p38 kinase-alpha (p38alpha) with IC50 values of 0.016 μM and 0.677 μM for p38α and p38β. It is selective for p38α kinase over 50 other kinases screened (including p38γ and p38δ with modest selectivity over p38β).
||SD-208 is a selective TGF-βRI (ALK5) inhibitor with IC50 of 48 nM, >100-fold selectivity over TGF-βRII.
||SMDA (symmetric dimethylarginine) is a methylated form of arginine found within all nucleated cells that is released into circulation after proteolysis, then excreted through the kidneys, and correlates well with GFR (glomerular filtration rate) in people, dogs, and cats.
||SEA0400 is a selective and potent inhibitor of the Na+-Ca2+ exchanger (NCX) that inhibits Na+-dependent Ca2+ uptake in cultured neurons, astrocytes, and microglia with IC50 of 33 nM, 5.0 nM and 8.3 nM, respectively. SEA0400 prevents sodium nitroprusside (SNP) from increasing ERK and p38 MAPK phosphorylation and production of reactive oxygen species (ROS) in an extracellular Ca(2+)-dependent manner.
||Sebacic acid (1,8-Octanedicarboxylic acid) is a saturated, straight-chain naturally occurring dicarboxylic acid
||SEC inhibitor KL-1
||SEC inhibitor KL-1 (KL-1) is a potent and selective inhibitor of super elongation complex (SEC) that disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. KL-1 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with Ki of 3.48 μM.
||Sec-O-Glucosylhamaudol (Hamaudol 3-glucoside) is one of the major bioactive compounds of the Saposhnikoviae Radix.
||SecinH3 is a selective cytohesin inhibitor with IC50 of 2.4 μM, 5.4 μM, 5.4 μM, 5.6 μM, 5.6 μM, and 65 μM for hCyh2, hCyh1, mCyh3, hCyh3, drosophila steppke, and yGea2-S7, respectively.
||Seclidemstat (SP-2577) is a potent and orally bioavailable inhibitor of lysine-specific demethylase 1 (LSD1/KDM1A) with IC50 of 127 nM. Seclidemstat (SP-2577) has potential antineoplastic activity.
||Secnidazole (Flagentyl, PM 185184, RP 14539) is a nitroimidazole anti-infective.
||Secoisolariciresinol diglucoside (SDG), a plant lignan isolated from flaxseed, has strong antioxidant activity, cardioprotective effects, reduces the blood levels of low-density lipoprotein cholesterol, and reduces the risk of hormone related cancer.
||Secretin Acetate is a hormone that controls the secretions into the duodenum, and also separately, water homeostasis throughout the body.
||Secukinumab (anti-IL-17A) (Cosentyx, AIN457) is a human IgG1κ monoclonal antibody that binds to the protein interleukin (IL)-17A, and is applied for the treatment of psoriasis, ankylosing spondylitis, and psoriatic arthritis. MW=147.9 kDa.
||Securinine, a major natural alkaloid product from the root of the plant Securinega suffruticosa, acts as a γ-amino butyric acid (GABA) receptor antagonist.
||SEL120 (SEL120-34A) hydrochloride
||SEL120 (SEL120-34, SEL120-34A) is a novel inhibitor of Cyclin-dependent kinase 8 (CDK8) with IC50 values of 4.4 nM and 10.4 nM for CDK8/Cyclin C and CDK19/CyclinC respectively.
||SEL-201 (SLV-2436, SEL201-88) is a highly potent and ATP-competitive inhibitor of MNK1 and MNK2 with IC50 of 10.8 nM and 5.4 nM, respectively.
||Selamectin (UK-124114) is a novel macrocyclic lactone of the avermectin class. It paralyses and/or kills a wide range of invertebrate parasites through interference with their chloride channel conductance causing disruption of normal neurotransmission and has adulticidal, ovicidal and larvicidal activity against fleas.
||Selective JAK3 inhibitor 1
||Selective JAK3 inhibitor 1 is an irreversible JAK3 inhibitor with Ki values of 0.07 nM, 320 nM, 740 nM for JAK3, JAK1 and JAK2 respectively. It is also selective over the other kinases possessing a cysteine in the same region as JAK3, such as BMX, EGFR, ITK, and BTK.
||Selective PI3Kδ Inhibitor 1 (compound 7n)
||Selective PI3Kδ Inhibitor 1 (compound 7n) is an inhibitor of PI3Kδ with an IC50 of 0.9 nM and >1000-fold selectivity against other class I PI3K isoforms [PI3K α/γ/β=3670/1460/21300 nM].
||Seletalisib (UCB-5857) is a novel small-molecule inhibitor of PI3Kδ with an IC50 value of 12 nM and shows significant selectivity to PI3Kδ with respect to the other class I PI3K isoforms (between 24- and 303-fold).
||Selexipag (NS-304, ACT-293987) is an orally active, first-in-class, selective prostacyclin IP receptor agonist with Ki value of 260 nM for human IP, whereas Ki values > 10,000 nM are measured at the other human G-protein-coupled prostanoid receptors (EP1-4, DP, FP and TP).
||Selinexor (KPT-330, ATG-010) is an orally bioavailable selective CRM1 inhibitor. Phase 2.
||Selisistat (EX 527)
||Selisistat (EX 527, SEN0014196) is a potent and selective SIRT1 inhibitor with IC50 of 38 nM in a cell-free assay, exhibits >200-fold selectivity against SIRT2 and SIRT3. Phase 2.
||Selitrectinib (LOXO-195, BAY 2731954) is an orally available, highly potent, and selective TRK kinase inhibitor with low nanomolar inhibitory activity against TRKA G595R, TRKC G623R, and TRKA G667C, IC50s ranging from 2.0 to 9.8 nmol/L. It is more than 1,000-fold selective for 98% of non-TRK kinases tested.
||Selonsertib (GS-4997) is a highly selective and potent once-daily oral ASK1 inhibitor with potential anti-inflammatory, antineoplastic and anti-fibrotic activities.
||Selpercatinib (LOXO-292, ARRY-192) is a potent and specific RET (c-RET) inhibitor with IC50 values of 1 nM, 2 nM, 2 nM, 4 nM, 2 nM, 2 nM for WT RET, RET V804M, RET V804L, RET A883F, RET M918T and RET S891A respectively.
||Seltorexant (JNJ-42847922) is a potent, selective and orally active antagonist of orexin-2 receptor (OX2R) with pKi of 8.0 and 8.1 for human OX2R and rat OX2R, respectively. Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain.
||Selumetinib (AZD6244, ARRY-142886) is a potent, highly selective MEK inhibitor with IC50 of 14 nM for MEK1 and Kd value of 530 nM for MEK2. It also inhibits ERK1/2 phosphorylation with IC50 of 10 nM, no inhibition to p38α, MKK6, EGFR, ErbB2, ERK2, B-Raf, etc. Selumetinib suppresses cell proliferation, migration and trigger apoptosis. Phase 3.
||Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, also inhibits Notch signaling with IC50 of 14.1 nM in H4 human glioma cell. Phase 3.
||Semaglutide (Rybelsus, Ozempic, NN9535, OG217SC, NNC 0113-0217), a long-acting glucagon-like peptide 1 (GLP-1) analogue, is a GLP-1 receptor agonist with the potential for the treatment of type 2 diabetes mellitus (T2DM).
||Semaxanib (SU5416) is a potent and selective VEGFR(Flk-1/KDR) inhibitor with IC50 of 1.23 μM, 20-fold more selective for VEGFR than PDGFRβ, lack of activity against EGFR, InsR and FGFR. Phase 3.
SEN 12333 (WAY-317538) is a potent, selective and orally active α7 nAChR agonist.
||Senecioic acid (3-Methylcrotonic acid, 3,3-Dimethylacrylic acid, β-Methylcrotonic Acid) is an unsaturated fatty acid found in the pheromones of mealybug species and appears in the urine of patients with 3-Methylcrotonic aciduria.
||Senegenin (Tenuigenin) is a natural product from Polygala tenuifolia used in Chinese medicine with antioxidative and antiinflammatory activity.
||Senexin A is a potent and selective inhibitor of CDK8 and its nearest relative, CDK19 with Kd values of 0.83 μM and 0.31 μM for CDK8 and CDK19 ATP site binding, respectively.
||Senkyunolide A is one of the major bioactive ingredients in Rhizoma Chuanxiong, a Chinese medicinal herb commonly used for the treatment of cardiovascular ailments.
||Senkyunolide I (SEI, SENI) is an orally active compound isolated from Ligusticum chuanxiong with analgesic, anti-migraine, neuroprotective, anti-oxidation and anti-apoptosis activities. Senkyunolide I (SEI, SENI) up-regulates the phosphorylation of Erk1/2 and induces Nrf2 nuclear translocation with enhanced HO-1 and NQO1 expressions. Senkyunolide I (SEI, SENI) promotes the ratio of Bcl-2/Bax and inhibits the expressions of cleaved caspase 3 and caspase 9.
||Sennoside A (NSC 112929), a kind of irritant laxative isolated from rhei rhizome, causes purgative actions in the intestine.
||Sennoside B, a kind of irritant laxative isolated from rhei rhizome, inhibits PDGF-stimulated cell proliferation.
||Sephin-1 (NSC-65390) is a selective inhibitor of a holophosphatase, a small molecule that safely and selectively inhibits a regulatory subunit of protein phosphatase 1 in vivo. Sephin-1 (NSC-65390) selectively bounds and inhibits the stress-induced PPP1R15A.
||Sepimostat (FUT-187 free base) is an inhibitor of Ifenprodil binding with Ki of 27.7 μM. Sepimostat is an antagonist of NR2B N-methyl-D-aspartate receptor acting at the Ifenprodil-binding site of the NR2B subunit with neuroprotective activity.
||Serabelisib (TAK-117, INK-1117, MLN-1117) is a potent and selective oral PI3Kα isoform inhibitor (IC50 of 21 nmol/L against PI3Kα) that has demonstrated > 100-fold selectivity relative to other class I PI3K family members (PI3Kβ/γ/δ) and mTOR, and a high degree of selectivity against many other kinase.
||Seralutinib (PK10571, GB002) is a novel PDGFR kinase inhibitor with IC50s of 8 nM and 10 nM for PDGFRα and PDGFRβ in enzyme assays, respectively.
||Seratrodast (AA-2414, ABT-001) is a potent and selective thromboxane A2 receptor (TP) antagonist which is used primarily in the treatment of asthma and used as anti-inflammatory agent.
||Serdemetan (JNJ-26854165) acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells, inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53. Phase 1.
||Serotonin creatinine sulfate monohydrate
Serotonin (5-Hydroxytryptamine) creatinine sulfate monohydrate is an active endogenous metabolite.
||Serotonin HCl (5-HT) is a monoamine neurotransmitter and Endogenous 5-HT receptor agonist.
||Sertaconazole nitrate (FI-7045) is a topical broad-spectrum antifungal that is developed to provide an additional agent for the treatment of superficial cutaneous and mucosal infections.
||Sertraline HCl (CP-51974-1) is a 5-HT antagonist with Ki of 13 nM.
||Sesamin (Fagarol, Fsesamin), a lignan isolated from the bark of Fagara plants and from sesame oil, exhibits various health benefits.
||Sesamol (1,3-Benzodioxol-5-ol, 3,4-Methylenedioxyphenol), a natural organic compound, is regarded as a major antioxidant component in the oil with chemoprevention, antimutagenic, and antihepatotoxic activities. It induces apoptosis of cancer and cardiovascular cells.
||Setanaxib (GKT137831, GKT831) is a potent, dual NADPH oxidase NOX1/NOX4 inhibitor with Ki of 110 nM and 140 nM, respectively. Treatment with GKT137831 suppresses reactive oxygen species (ROS) production. GKT137831 partly inhibits ferroptosis.
||Setipiprant (ACT-129968, KYTH-105) is a selective, orally available antagonist of the prostaglandin D2 receptor 2 (DP2) that that has been shown to have greater specificity for DP2 (CRTH2) than for DP1.
Setmelanotide (RM-493, BIM-22493, CAM 4072) is a cyclic peptide full agonist of melanocortin-4 receptor (MC4R) with an EC50 of 0.27 nM and a Ki of 2.1 nM.
||Sevelamer carbonate is a non-absorbed phosphate binding crosslinked polymer, with the same polymeric structure as sevelamer hydrochloride, in which carbonate replaces chloride as the counterion.
||Sevelamer HCl is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption.
||Sevoflurane (Fluoromethyl) is a noncompetitive inhibitor of 5-HT3 receptor. Sevoflurane acts as a low-soluble inhalation anesthetics.
||SEW 2871 is a highly selective, orally active S1P1 agonist with EC50 of 13.8 nM.
||SF1670 is a highly potent and specific PTEN inhibitor with IC50 of 2 μM.
||SF2/ASF Rabbit Recombinant mAb
||SF2/ASF Rabbit Recombinant mAb detects endogenous level of total SF2/ASF.
||SF2523 is a highly selective and potent inhibitor of PI3K with IC50 values of 34 nM, 158 nM, 9 nM, 241 nM and 280 nM for PI3Kα, PI3Kγ, DNA-PK, BRD4 and mTOR, respectively.
||SGA360 is a selective modulator of aryl hydrocarbon (Ah) receptor that exhibits anti-inflammatory properties.
||SGC 0946 is a highly potent and selective DOT1L methyltransferase inhibitor with IC50 of 0.3 nM in a cell-free assay, is inactive against a panel of 12 PMTs and DNMT1.
SGC-AAK1-1 is a potent and selective AAK1 (AP2 associated kinase 1) inhibitor with an IC50 of 270 nM and a Ki of 9 nM.
||SGC-CBP30 is a potent CREBBP/EP300 inhibitor with IC50 of 21 nM and 38 nM in cell-free assays, respectively. Exhibits 40-fold and 250-fold selectivity for CBP over the first BRD of BRD4 (BRD4(1)) and BRD4(2) respectively.
||SGC-GAK-1 is a potent, selective, and cell-active inhibitor of cyclin G-associated kinase (GAK) with Ki value of 3.1 nM and >50-fold selectivity over nearest kinase.
||SGC2085 hydrochloride is a potent and selective inhibitor of coactivator associated arginine methyltransferase 1 (CARM1) with IC50 of 50 nM.
||SGI-1027 (DNA Methyltransferase Inhibitor II) is a DNMT inhibitor with IC50 of 6, 8, 7.5 μM for DNMT1, DNMT3A, and DNMT3B in cell-free assays, respectively. SGI‑1027 induces apoptosis.
||SGI-1776 free base
||SGI-1776 free base is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM in a cell-free assay, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. SGI-1776 induces apoptosis and autophagy. Phase 1.
||SGI-7079, a novel selective Axl inhibitor with an IC50 of 58 nM in vitro, inhibits tumor growth in a dose dependent manner and is a potential therapeutic target for overcoming EGFR inhibitor resistance.
SGN‐2FF (2-fluorofucose) is an orally bioavailable small‐molecule inhibitor of fucosyltransferase that demonstrated encouraging preclinical antitumor activity in mouse models.
||SGX-523 is a selective Met (c-Met) inhibitor with IC50 of 4 nM, no activity to BRAFV599E, c-Raf, Abl and p38α. Phase 1.
||SHA 68 is a potent and selective antagonist of non-peptide neuropeptide S receptor (NPSR) with IC50 of 22.0 nM and 23.8 nM for NPSR Asn107 and NPSR Ile107, respectively. SHA 68 limits the blood-brain barrier (BBB) penetration and the activity in neuralgia.
||Shanzhiside methyl ester
||Shanzhiside methylester is a principle effective iridoid glycoside of L. rotata and serves as a small molecule glucagon-like peptide-1 (GLP-1) receptor agonist.
||Shield-1 is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP). Shield-1 reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused proteins. Shield-1 stabilizes the entire fusion protein.
||Shikimic acid (Shikimate), more commonly known as its anionic form shikimate, is an important biochemical intermediate in plants and microorganisms.
||Shikonin (C.I. 75535)
||Shikonin (C.I. 75535, Anchusin, Anchusa acid, Alkanna Red, Isoarnebin 4, NSC 252844), a potent and specific Pyruvate kinase M2 (PKM2) inhibitor, is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities. It is also an inhibitor of TMEM16A chloride channel activity using cell-based fluorescent-quenching assay. Shikonin exerts an anti-inflammatory effect by inhibiting tumor necrosis factor-α (TNF-α) and prevents activation of nuclear factor-κB (NF-κB) pathway via proteasome inhibition.
Shionone is a triterpenoid component derived from the herbal medicine Aster tataricus, anit has anti-inflammatory properties. Shionone specifically inhibits NLRP3 inflammasome activation in vitro and in vivo.
SHIP2-IN-1 is a potent SHIP2 inhibitor with an IC50 of 2 µM.
||SHP099 is a highly potent, selective and orally bioavailable small-molecule SHP2 inhibitor with an IC50 value of 71 nM and shows no activity against SHP1.
||SHP099 is a highly potent, selective and orally bioavailable small-molecule SHP2 inhibitor with an IC50 value of 0.071 μM and shows no activity against SHP1.
||SHP1 Rabbit Recombinant mAb
||SHP1 Rabbit Recombinant mAb detects endogenous level of total SHP1.
||SHP2 Rabbit Recombinant mAb
||SHP2 Rabbit Recombinant mAb detects endogenou level of total SHP2.
SHR0302 is a potent and orally active inhibitor of pan-JAK. The selectivity of SHR0302 for JAK1 is >10-fold for JAK2, 77-fold for JAK3, 420-fold for Tyk2.
||SIA Crosslinker is a non-cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
||SIB 1757 is a highly selective, noncompetitive antagonist of metabotropic glutamate receptor type 5 (mGluR5) with IC50 of 0.4 μM at hmGluR5 compared with >30 µM at hmGluR1b, hmGluR2, hmGluR4, hmGluR6, hmGluR7 and hmGluR8.
||SIBA (5′-Isobutylthio-5′-deoxyadenosine, 5'-Deoxy-5'-isobutylthioadenosine, 5'-Isobutylthioadenosine) is a synthetic analogue of S-adenosylhomocysteine and is a powerful antipro-liferative drug. SIBA is not only an inhibitor of transmethylation but also interferes with polyamine biosynthesis, probably by blocking aminopropyltransferase.
||Sildenafil (Revatio, UK-92480, Viagra) is a Phosphodiesterase 5 Inhibitor with IC50 of 5.22 nM.
||Sildenafil Citrate, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5), is a well-tolerated and highly effective treatment for erectile dysfunction.
||Sildenafil Mesylate is a mesylate form of Sildenafil, an inhibitor of Phosphodiesterase 5.
||Silibinin (NSC 651520)
||Silibinin (NSC 651520, Silybin, Silibinin A, Silymarin I, Flavobin), the main flavonoid extracted from the milk thistle Silybum marianum, displays hepatoprotective properties in acute and chronic liver injury.
||Silmitasertib (CX-4945) is a potent and selective inhibitor of CK2 (casein kinase 2) with IC50 of 1 nM in a cell-free assay, less potent to Flt3, Pim1 and CDK1 (inactive in cell-based assay). Silmitasertib induces autophagy and promotes apoptosis. Phase 1/2.
||Silmitasertib (CX-4945) sodium salt
||Silmitasertib (CX-4945) sodium salt is a potent, orally bioavailable and selective inhibitor of casein kinase 2 (CK2) with IC50 of 1 nM against CK2α and CK2α'.
||Silodosin (KAD 3213, KMD 3213) is a highly selective α1A-adrenoceptor antagonist, used in treatment of benign prostatic hyperplasia.
||Siltuximab (anti-IL-6) (CNTO 328) is a human-mouse chimeric monoclonal antibody that binds human interleukin-6 (IL-6).
||Silver sulfadiazine is a bactericidal for many gram- negative and gram-positive bacteria as well as being effective against yeast.
||Silymarin (Silybin B), a polyphenolic flavonoid extracted from the seeds of Silybum marianum or milk thistle, is used in the prevention and treatment of liver diseases and primary liver cancer.
||Simeprevir (TMC-435, TMC-435350) is a competitive, reversible, macrocyclic, noncovalent hepatitis C virus (HCV) NS3/4A protease inhibitor that acts directly against the hepatitis C virus. It has a medium inhibitory concentration (IC50) <13 nM for all HCV NS3/4A enzymes(genotypes 1a, 1b, 2, 4, 5, and 6), but has an IC50 value of 37 nM for genotype 3.
Simethicone (Simeticone) is a nonabsorbable, surface-active, antifoaming agent.
||Simetride, a non-narcotic analgesic, is an ingredient of Kyorin AP2 which is used to treat low back pain, symptomatic neuralgia, headache, menstrual pain and etc.
Simufilam (PTI-125) is a low toxicity, orally active filamin A (FLNA) activator. PTI-125 preferentially binds altered FLNA and restores its native conformation, restoring receptor and synaptic activities and reducing its α7nAChR/TLR4 associations and downstream pathologies.
||Simufilam (PTI-125) Dihydrochloride is a small molecule modulator that preferentially binds altered FLNA and restores its native conformation, restoring receptor and synaptic activities and reducing its α7nAChR/TLR4 associations and downstream pathologies.
||Simvastatin (MK 733)
||Simvastatin (MK-0733, MK 733) is a competitive inhibitor of HMG-CoA reductase with Ki of 0.1-0.2 nM in cell-free assays. Simvastatin induces ferroptosis, mitophagy, autophagy and apoptosis.
||Sinapine is an alkaloid isolated from seeds of the cruciferous species with antioxidant, antitumor and radio-protective activities. Sinapine inhibits the proliferation of Caco-2 cells via downregulation of P-glycoprotein.
||Sinapinic acid (Sinapic acid) is a small naturally occurring hydroxycinnamic acid which belongs to phenylpropanoid family and commonly used as matrix in MALDI mass spectrometry. Sinapinic acid (Sinapic acid) acts as an inhibitor of HDAC, with IC50 of 2.27 mM, and also inhibits ACE-I activity.
||Sincalide (Kinevac) is a synthetically-prepared C-terminal octapeptide of cholecystokinin.
||Sinensetin (Pedalitin Permethyl ether), a natural polymethoxylated flavone, has potent antiangiogenesis activity.
||Sinigrin (Allylglucosinolate, 2-Propenylglucosinolate) is a glucosinolate found in some plants of the Brassicaceae family and exerts various activities including anticancer, anti-inflammatory, antibacterial, antifungal, antioxidant, and wound healing effects.
||Sinoacutine (Salutaridine), isolated from the Chinese drug Ching-fengteng, elicits mild antitussive properties.
||Sinomenine (Cucoline, Kukoline), a pure alkaloid extracted from the chinese medical plant Sinomenium acutum, is used for the treatment of rheumatism and arthritis.
||Sinomenine (SN, Cucoline, Kukoline, Sabianine A), extracted from the Chinese medicinal plant, sinomenium acutum, is a potent anti-inflammatory and neuroprotective agent.
||Sintilimab (anti-PD-1, IBI 308) is a fully human IgG4 monoclonal antibody that binds to PD-1 on the surface of T-cells, blocks the PD-1/PD-Ligand 1 (PD-L1) pathway, and reactivates T-cells to kill cancer cells.
||BAF312 (Siponimod) is a next-generation S1P receptor agonist, selective for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, exhibits >1000-fold selectivity over S1P2, S1P3 and S1P4 receptors. Phase 3.
||Siramesine (Lu 28-179) is a sigma receptor agonist, selective for the σ2 subtype with IC50 values of 0.12 nM and 17 nM for σ2 and σ1 receptors respectively.
||SIRT1 Rabbit Recombinant mAb
SIRT1 Antibody detects endogenous levels of total SIRT1.
||SIRT6 Rabbit Recombinant mAb
SIRT6 Antibody detects endogenous levels of SIRT6.
||SIS17 is a mammalian histone deacetylase 11 (HDAC 11)-specific inhibitor with IC50 of 0.83 μM. SIS17 inhibits the demyristoylation of HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs.
||SIS3 is a cell-permeable inhibitor of SMAD3 that selectively inhibits TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated cellular signaling. SIS3 reduce TGF-β1-induced type 1 procollagen expression and myofibroblast differentiation in normal dermal fibroblasts as well as scleroderma fibroblasts.
||SIS3, a novel specific inhibitor of Smad3, inhibits TGF-β and activin signaling by suppressing Smad3 phosphorylation without affecting the MAPK/p38, ERK, or PI3-kinase signaling pathways.
||Sisomicin sulfate is an aminoglycoside antibiotic, isolated from the fermentation broth of a new species of the genus Micromonospora.
||Sitafloxacin Hydrate (DU-6859a) is a new-generation, broad-spectrum oral fluoroquinolone antibiotic.
||Sitagliptin (MK-0431) is an oral and highly selective DPP-4 inhibitor with an IC50 of 18 nM. It is used for the treatment of type 2 diabetes.
||Sitagliptin phosphate monohydrate
||Sitagliptin phosphate monohydrate (MK-0431) is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts.
||Sitravatinib (MGCD516, MG-516) is a novel small molecule inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Kit, PDGFRβ, PDGFRα, c-Met, and Axl.
||Sivelestat (ONO5046, LY544349, EI546) is a potent and selective inhibitor of neutrophil elastase with IC50 of 44nM. It almost shows no activity at a range of other proteases.
||Sivelestat sodium tetrahydrate
||Sivelestat sodium tetrahydrate (ONO5046-Na, EI546, LY544349) is a competitive inhibitor of human neutrophil elastase, also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse.
SJ-172550 is the first small molecule inhibitor of MDMX. SJ-172550 binds the p53-binding pocket of MDMX, thereby displacing p53.
||SJ000291942 is a canonical bone morphogenetic proteins (BMP) signaling pathway activator.
||SJA710-6 is a small molecule that can selectively differentiate MSCs toward hepatocyte-like cells.
||SJB2-043 is a potent USP1 inhibitor that inhibits the activity of native USP1/UAF1 with IC50 of 544 nM.
||SKA-31 (Naphtho[1,2-d]thiazol-2-ylamine) is a potent activator of potassium channel with EC50 of 260 nM, 1.9 μM, 2.9 μM, and 2.9 μM for KCa3.1, KCa2.2, KCa2.1 and KCa2.3, respectively.
||Skatole (3-methylindole, Scatole) is a mildly toxic white crystalline organic compound that occurs naturally in feces. It has a fairly broad bacteriostatic effect.
||Skepinone-L (CBS3830) is a selective p38α-MAPK inhibitor with IC50 of 5 nM.
||SKF38393 HCl is a selective dopamine D1/D5 receptor agonist.
||SKF96365, originally identified as a blocker of receptor-mediated calcium entry, is widely used diagnostically, as a blocker of transient receptor potential canonical type (TRPC) channels.
||SKI II (SphK-I2) is a highly selective and non ATP-competitive sphingosine kinase (SphK) inhibitor with IC50 of 0.5 μM, while exhibiting no inhibitory action on other kinases including PI3K, PKCα and ERK2.
||SKI-178 is a potent inhibitors of sphingosine kinase-1 (SphK1) and SphK2 with IC50 values ranging from ∼500 nM to ∼1 μM depending on AML cell lines.
||SKI V is a noncompetitive and potent inhibitor of non-lipid sphingosine kinase with IC50 of 2 μM for GST-hSK. SKI-V also inhibits PI3K with IC50 of 6 μM for hPI3k. SKI-V decreases formation of the mitogenic second messenger sphingosine-1-phosphate (S1P) and induces apoptosis with antitumor activity.
||SKLB-610 is a multi-target inhibitor of the tyrosine kinases. It is most potent against VEGFR2 and exhibits slightly weaker inhibitor of FGFR2 and PDGFR.
||SKLB-23bb is an orally bioavailable HDAC6-selective inhibitor with IC50 values under 100 nmol/L, against most of the cell lines checked. It also has microtubule-disrupting ability.
||SKLB4771 is a potent and selective inhibitor of human receptor-type tyrosine-protein kinase FLT3 with IC50 of 10 nM.
||Skp2 inhibitor C1 (SKPin C1)
||Skp2 inhibitor C1 (SKPin C1) is a specific and selective small-molecule inhibitor of Skp2-mediated p27 degradation by reducing p27 binding through key compound-receptor contacts.
||SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/ 0.22 μM, no activity towards Erk1, MKK3, MKK4, c-JUN, PKC, PKA, or CamKII;capable of transport through the blood-brain barrier.
||SLC13A5-IN-1 is a selective inhibitor of sodium-citrate co-transporter (SLC13A5). SLC13A5-IN-1 completely blocks the uptake of 14C-citrate with IC50 of 0.022 μM in HepG2 cells. SLC13A5-IN-1 has the potential for the treatment of metabolic and/or cardiovascular diseases.
||Slingshot inhibitor D3
Slingshot inhibitor D3 is a potent, selective, reversible and competitive inhibitor of Slingshot with IC50 of 3 μM for Slingshot 1 and Ki of 3.9 μM for Slingshot 2.
||SM 324405 (compound 9e) is a potent and selective Toll-like receptor 7 (TLR7) agonist with EC50 of 50 nM.
||SM-102 is a amino cationic lipid used to form the nanoparticle which carries the mRNA to cells in the body.
||SM-164 is a potent, non-peptide, cell-permeable antagonist of XIAP that targets both the BIR2 and BIR3 domains with IC50 of 1.39 nM. SM-164 induces apoptosis and tumor regression.
||SM-276001 is a potent and selective agonist of TLR7 that induces antitumor immune responses. SM-276001 is an orally active interferon (IFN) inducer.
||Smad4 Rabbit Recombinant mAb
||Smad4 Rabbit Recombinant mAb detects endogenous level of total Smad4.
||SMAD5 Rabbit Recombinant mAb
||SMAD5 Rabbit Recombinant mAb detects endogenous level of total SMAD5.
||Small Molecule Immuno-Oncology Compound Library
||A unique collection of 248 Immuno-Oncology small molecules used for oncotherapy in conjunction with other drugs.
||SMCC (Succinimidyl-4-(N-maleimidomethyl cyclohexane)-1-carboxylate) is a hetero-bifunctional crosslinker that contain N-hydroxysuccinimide (NHS) ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl-containing molecules. SMCC-conjugated antigen couples spleen cells to induce antigen-specific immune responses.
||SMI-16a is a selective Pim kinase inhibitor with IC50 values of 150 nM and 20 nM for Pim1 and Pim2 respectively.
||SMI-4a (TCS PIM-1 4a) is a potent inhibitor of Pim1 with IC50 of 17 nM, modestly potent to Pim-2, does not significantly inhibit any other serine/threonine- or tyrosine-kinases.
SMIFH2 is a specific inhibitor of formin that inhibits formin-driven actin polymerization in vitro with IC50s ranging from 5 to 15 μM for different formins.
||Smoothened Agonist (SAG)
Smoothened Agonist (SAG) is potent agonist of Smoothened (Smo). Smoothened Agonist induces firefly luciferase expression in Shh-LIGHT2 cells with an EC50 of 3 nM.
||Smoothened Agonist (SAG) HCl
||Smoothened Agonist (SAG) HCl is a cell-permeable Smoothened (Smo) agonist with EC50 of 3 nM in Shh-LIGHT2 cells.
||Smurf1-IN-A01 can inhibit Smurf1-mediated Smad1/5 degradation and accelerate BMP-2 signal responsiveness with a Kd of 3.664 nM.
||SMYD3 Rabbit Recombinant mAb
||SMYD3 Rabbit Recombinant mAb detects endogenous level of total SMYD3.
||SN-011 (GUN35901) is a STING-specific antagonist with IC50 of 76 nM.
||SN-38 (NK012) is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks. SN-38 induces autophagy.
||SN-6 is a selective Na+/Ca2+ exchanger (NCX) inhibitor. SN-6 inhibits NCX1, NCX2, and NCX3 with IC50 of 2.9 μM, 16 μM and 8.6 μM, respectively. SN-6 abolishes acetylcholine (ACh)-induced vasodilation.
||SN50 (NF-κB SN50), a cell-permeable NF-κB inhibitory peptide, is composed of the signal peptide of Kaposi fibroblast growth factor.SN50 inhibits the activation of NF-κB and attenuates ventilator-induced lung injury.
||SNAP 94847 hydrochloride is a novel, high affinity selective melanin-concentrating hormonereceptor1 (MCHR1) antagonist with Ki of 2.2 nM and Kd of 530 pM. SNAP 94847 binds with high affinity to the mouse and rat MCHR1 with minimal cross-reactivity to other GPCR, ion channels, enzymes, and transporters.
||SNDX-5613 is a potent and selective inhibitor of menin-MLL binding with a Ki of 0.15 nM. SNDX-5613 shows anti-proliferative activity against multiple cell lines harboring MLLr translocations (MV4;11, RS4;11, MOLM-13, KOPN-8) with IC50 values ranging from 10-20 nM.
||SNG-1153 is a synthetic modulator of estrogen receptor ER-α36 with anticancer activity.
||SNS-032 (BMS-387032) has firstly been described as a selective inhibitor of CDK2 with IC50 of 48 nM in cell-free assays and is 10- and 20-fold selective over CDK1/CDK4. It is also found to be sensitive to CDK7/9 with IC50 of 62 nM/4 nM, with little effect on CDK6. SNS-032 (BMS-387032) induces apoptosis. Phase 1.
||SNS-314 is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively. It is less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2. Phase 1.
||SNS-314 Mesylate is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively and less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2.
||SNX-2112 (PF-04928473) selectively binds to the ATP pocket of HSP90α and HSP90β with Ka of 30 nM and 30 nM, uniformly more potent than 17-AAG.
||SOD1 Rabbit Recombinant mAb
||SOD1 Rabbit Recombinant mAb detects endogenous levels of total SOD1.
||SOD2 Rabbit Recombinant mAb
||SOD2 Rabbit Recombinant mAb detects endogenous level of total SOD2.
Sodium 2-(1H-indol-3-yl)acetate (3-Indoleacetic acid sodium, Indole-3-acetic acid sodium, 3-IAA sodium) is an endogenous metabolite.
Sodium 2-hydroxybutanoate (Sodium 2-hydroxybutyrate, Sodium DL-2-hydroxybutyrate), converted from 2-Aminobutyric acid, is an intermediate metabolite.
||Sodium 4-aminohippurate is a derivative of hippuric acid.
||Sodium Aescinate (SA, Escin Sodium Salt) is a widely-applied triterpene saponin product derived from horse chestnut seeds, possessing vasoactive and organ-protective activities with oral or injection administration in the clinic. Sodium aescinate is a triterpene saponin derived from Aesculus hippocastanum seeds, with anti-inflammatory and antioxidant activities. Sodium aescinate inhibits hepatocellular carcinoma growth by targeting CARMA3/NF-κB pathway.
||Sodium Ascorbate is a more bioavailable form of vitamin C that is an alternative to taking ascorbic acid as a supplement.
||Sodium benzoate (Benzoic acid sodium salt) is a preservative and uesd as a food additive which is bacteriostatic and fungistatic under acidic conditions.
||Sodium butyrate (NaB, Butanoic acid sodium salt), sodium salt of butyric acid, is a histone deacetylase inhibitor and competitively binds to the zinc sites of class I and II histone deacetylases (HDACs). Sodium butyrate (NaB) inhibits cell cycle progression, promotes differentiation, and induces apoptosis and autophagy in several types of cancer cells.
||Sodium Carbonate (Disodium carbonate, Soda Ash, Carbonic acid disodium salt) is the disodium salt of carbonic acid with alkalinizing property.
||Sodium cholate (NaCh) is the sodium salt of the naturally occurring cholic acid, a bile salt produced by the liver, with strong solubilization capacity of water-insoluble substances.
||Sodium citrate dihydrate
||Sodium citrate dehydrate (Trisodium citrate dihydrate, Citric acid trisodium salt dihydrate) is the preferred anticoagulant.
||Sodium Danshensu is a mono sodium of danshensu, which is a natural phenolic acid of caffeic acid derivatives isolated from Salvia miltiorrhiza.
||Sodium dehydroacetate is the sodium salt of dehydroacetic acid, a fungicide and bactericide that is commonly used as a food preservative. Sodium dehydroacetate is a preservative that is used in the formulation of cosmetics and personal care products in order to extend the shelf-life by preventing microbial contamination.
||Sodium Dehydrocholate is a semisynthetic bile acid made from cholic acid. It has been used for stimulation of biliary lipid secretion.
||Demethylcantharidin (norcantharidin) is a synthetic analogue of cantharidin and has potent antitumor activity.
||Sodium dichloroacetate (DCA)
||Sodium dichloroacetate (DCA, Dichloroacetic acid, bichloroacetic acid, BCA), a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress Na+-K+-2Cl- cotransporter and a mitochondrial potassium-ion channel axis. Sodium dichloroacetate increases reactive oxygen species (ROS) generation, triggers apoptosis in cancer cells, and inhibits tumor growth.
||Sodium erythorbate (NaE, D-Isoascorbate, Erythorbic acid sodium salt, Araboascorbic acid monosodium salt, Erbit N, Eribate N, Isoascorbate C sodium) is the sodium of erythorbic acid, a highly refined food-grade chemical closely related to vitamin C, synthesized from sugar, and used as a color fixative in preparing cured meats.
||Sodium Etidronate (Didronel, EHDP, Etidronic acid) is a non-aminobisphosphonate that exhibits protein tyrosine phosphatase (PTP) inhibitory activity.
||Sodium ferulate (SF, Ferulic acid sodium salt), the sodium salt of ferulic acid, is a drug used in traditional Chinese medicine for treatment of cardiovascular and cerebrovascular diseases and to prevent thrombosis.
||Sodium fluoride (NaF) induces apoptosis and autophagy via the endoplasmic reticulum (ER) stress pathway in MC3T3-E1 osteoblastic cells.
||Sodium Glucoheptonate Dihydrate
||Sodium glucoheptonate is used for cleaning metal, mercerizing, paint stripping, and aluminum etching.
||Sodium gluconate is the sodium salt of gluconic acid widely used in food and pharmaceutical industry.
||Sodium gualenate (Guaiazulenesulfonate sodium), a hydrophilic derivative of guaiazulene (GA), is an unstable compound, which is gradually decomposed in the solid state at room temperature. It has anti-inflammatory and wound-healing effects.
||Sodium Houttuyfonate, the active compound of the Houttuynia plant, is mainly used for treating purulent skin infections, respiratory tract infections, including pneumonia in elderly patients, and chronic bronchitis.
||Sodium hyaluronate is the sodium salt of hyaluronic acid, a glycosaminoglycan found in various connective tissue of humans.
||Sodium ionophore III
Sodium ionophore III (ETH2120) is a sodium-selective ionophore suitable for the assay of sodium activity in blood, plasma, serum. etc.
||Sodium L-ascorbyl-2-phosphate (Sodium ascorbyl monophosphate, Sodium ascorbyl phosphate, SAP) is specifically produced for use as a stabilized source of vitamin C in cosmetic products. It is used in skin care recipes for UV protection, collagen production, as an antioxidant and for its skin lightening and brightening effects. Sodium L-ascorbyl-2-phosphate (2-Phospho-L-ascorbic acid trisodium salt, L-Ascorbic acid 2-phosphate trisodium salt, Sodium ascorbyl phosphate, SAP) is a selective antioxidant and a stimulator of hepatocyte growth factor (HGF) production.
||Sodium L-lactate is used as a food additive, preservative, acidity regulator and bulking agent.
||Sodium lauryl sulfate
||Sodium lauryl sulfate is an anionic detergent and surfactant found in many personal care products.
||Sodium mesoxalate monohydrate
Sodium mesoxalate monohydrate (sodium 2,2-dihydroxymalonate) is an endogenous metabolite.
||Sodium metatungstate (SMT) solution is an inorganic heavy liquid which is widely used in density fractionation. Sodium metatungstate (Sodium polyoxotungstates) is a potent and selective inhibitor of ecto-nucleoside triphosphate diphosphohydrolase (NTPDases, CD39) with Ki of 0.140 μM, 0.910 μM and 0.563 μM for NTPDase1, NTPDase2 and NTPDase3, respectively.
||Sodium Monensin (NSC 343257)
||Sodium Monensin (NSC 343257), isolated from Streptomyces cinnamonensis, is a well-known representative of naturally polyether ionophore antibiotics.
||Sodium Monofluorophosphate (NSC248) is a competitive inhibitor of pyruvate kinase and alkaline phosphatase with Ki of 3.4 mM and 69 μM, respectively, which also irreversibly inhibits phosphorylase phosphatase with Ki of 0.5 mM.
||Sodium nitrite is a myeloperoxidase inhibitor with IC50 of 1.3 μM.
||Sodium nitroprusside (SNP, Ro 21-2498) is a generically available and rapid-acting intravenous (IV) vasodilator that dilates cerebral vessels and increases internal carotid (ICA) flow.
||Sodium Nitroprusside Dihydrate
||Sodium Nitroprusside Dihydrate is a potent vasodilator working through releasing NO spontaneously in blood.
||Sodium oxamate (SO, Aminooxoacetic acid, Oxamic acid) is an inhibitor of lactate dehydrogenase (LDH) that specificly inhibits LDH‑A. Sodium oxamate (SO) induces G2/M cell cycle arrest via downregulation of the CDK1/cyclin B1 pathway and promotes apoptosis through enhancement of mitochondrial ROS generation.
||Sodium phenylbutyrate is a salt of 4-phenylbutyrate (4-PBA) or 4-phenylbutyric acid.Sodium phenylbutyrate is a histone deacetylase inhibitor, used to treat urea cycle disorders.
||Sodium phenylpyruvate (Phenylpyruvic acid sodium salt) inhibits amino acid formation and depresses oxygen consumption.
||Sodium phytate hydrate
||Sodium phytate hydrate (Phytic acid, Dodecasodium phytate, Myo-inositol hexakis, Inositol hexakisphosphate) functions as a storage depot and precursor for other inositol phosphates and pyrophosphates. It can be used clinically as a hypocalcemic agent and a complexing agent for removal of traces of heavy metal ions.
||Sodium Picosulfate inhibits absorption of water and electrolytes, and increases their secretion.
||Sodium salicylate is used in medicine as an analgesic and antipyretic.
||Sodium stibogluconate (SSG, Stibogluconate trisodium nonahydrate, Lenocta, VQD-001), a pentavalent antimony derivative, is a potent and selective inhibitor of protein tyrosine phosphatase (PTPase). Sodium stibogluconate inhibits 99% of Src homology 2 domain-containing phosphatase 1 (SHP-1) activity at 10 μg/ml and similar degrees of inhibition of SHP-2 and PTP1B requires 100 μg/ml. Sodium stibogluconate is a drug used in treatment of leishmaniasis.
||Sodium succinate (Sodium 3-carboxypropanoate, Disodium butanedioate) is the sodium salt form of succinate, which is an important metabolite at the cross-road of several metabolic pathways and involved in the formation and elimination of reactive oxygen species.
||Sodium Sulfadiazine (Sulfadiazin-natrium) is a sodium salt form of sulfadiazine, an intermediate-acting bacteriostatic, synthetic sulfanilamide derivative.
||Sodium tauroglycocholate (STGC, Tauroglycocholic acid sodium salt) is an absorption enhancer of transdermal permeation of drug.
||Sodium Tauroursodeoxycholate (TUDC)
||Sodium Tauroursodeoxycholate (TUDC) is a water soluble bile salt, used for the treatment of gallstones and liver cirrhosis.
||Sodium Thiocyanate (NaSCN, Sodium rhodanide, Sodium sulfocyanate, Sodium rhodanate), one of the main sources of the thiocyanate anion, is used as a precursor for the synthesis of pharmaceuticals and other specialty chemicals. Sodium thiocyanate (NaSCN) reduces IL-6, whereas increases IL-10 levels. Sodium thiocyanate also reduces ROS.
||Sofalcone (SU-88) is an antiulcer drug and a mucosal protective agent, increasing vascular endothelual growth factor via the Nrf2-heme-oxygenase-1 dependent pathway in gastric epithelial cells.
||Sofiniclin (ABT 894)
Sofiniclin (ABT 894) is an agonist of nicotinic acetylcholine receptor (nAChR) which is used as a potential non-stimulant research for attention-deficit/hyperactivity disorder (ADHD).
||Sofosbuvir (PSI-7977, GS-7977) is a HCV NS5B polymerase inhibitor for the treatment of chronic hepatitis C virus (HCV) infection.
||Solanesol (Nonaisoprenol, Betulanonaprenol) is a long-chain polyisoprenoid alcohol compound with inhibitory activities toward FAK. It mainly accumulates in solanaceous crops, including tobacco, tomato, potato, eggplant, and pepper plants.
||Solasodine (Purapuridine, Solancarpidine, Solasodin, Salasodine, Salasdine) is a poisonous alkaloid chemical compound that occurs in plants of the Solanaceae family. Solasodine reduces the mRNA level of matrix metalloproteinase-2 (MMP-2), MMP-9 and extracellular inducer of matrix metalloproteinase (EMMPRIN), but increases the expression of reversion-inducing cysteine-rich protein with kazal motifs (RECK). Solasodine downregulates oncogenic microRNA-21 (miR-21), which has been known to target RECK. Solasodine also reduces PI3K/Akt signaling pathways and downregulates expression of miR-21.
||Solcitinib (GLPG0778, GSK2586184) is an inhibitor of JAK1 with an IC50 of 8-9 nM, and shows 11-, 55- and 23-fold selectivity over JAK2, JAK3 and TYK2, respectively.
||Solifenacin (YM905) is a competitive muscarinic receptor antagonist. The binding of acetylcholine to these receptors, particularly the M3 receptor subtype, plays a critical role in the contraction of smooth muscle.
||Solifenacin succinate (YM905) is a urinary antispasmodic of the antimuscarinic class.
||Solithromycin (CEM-101, OP-1068), belonging to the well-known class of macrolide antibiotics that also includes azithromycin, is a potent bacterial protein synthesis inhibitor.
||Solvent Blue 35
||Solvent Blue 35 (Sudan Blue II, Oil Blue 35) is a member of the Sudan family of hydrophobic fat-staining dyes, predominantly used for staining triglycerides in animal tissues (frozen sections).
||Solvent Red 23
||Solvent Red 23 (Cerasin Red, Sudan III, Sudan Red III, Fettscharlach) is a solvent dye used to color nonpolar substances such as oils, fats, waxes, greases, various hydrocarbon products, and acrylic emulsions.
||Somatostatin Acetate is a peptide hormone that regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with G protein-coupled somatostatin receptors and inhibition of the release of numerous secondary hormones.
||Songorine, a ubiquitous alkaloid in the genus Aconitum, is a novel antagonist of the GABAA receptor in rat brain and has antiarrhythmic, antinociceptive, anti-inflammatory, regenerative and CNS-modulating properties.
||Sonidegib (Erismodegib, NVP-LDE225) is a Smoothened (Smo) antagonist, inhibiting Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human) in cell-free assays, respectively. Phase 3.
||Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
||Sophoridine (5-Epidihydrosophocarpine, Dihydro-5-episophocarpine), a natural product obtained from medicinal plants, has a variety of pharmacological effects, including anti-cancer and anti-arrhythmia, and affects the immune and central nervous systems.
||Sorafenib (BAY 43-9006)
||Sorafenib (BAY 43-9006, NSC-724772) is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity.
||Sorafenib (BAY 43-9006) tosylate
||Sorafenib (BAY 43-9006) tosylate is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib Tosylate inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib Tosylate induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity.
||Sorbic acid (2,4-Hexadienoic acid) is a naturally occurring compound that originated from the unripe berries of the Rowan Tree. It inhibits various bacteria, including sporeformers, at various stages of their life cycle (germination, outgrowth and cell division).
||Sorbitol (Glucitol) is a sugar alcohol and a sugar substitute.
||SOS1 Rabbit Recombinant mAb
||SOS1 Rabbit Recombinant mAb detects endogenous level of total SOS1.
||Sotagliflozin (LX4211, LP-802034) is an oral dual SGLT1/SGLT2 inhibitor with IC50 of 36 nM and 1.8 nM, respectively. Phase 3.
||Sotalol is a non-selective beta blocker and a potassium channel blocker with an IC50 of 43 μM.
Soticlestat (TAK-935, OV935) is a first-in-class, selective and orally active cholesterol 24-hydroxylase (CYP46A1) inhibitor.
||Sotorasib (AMG510) is a potent KRAS G12C covalent inhibitor with potential antineoplastic activity.This AMG510 is a chiral compound.
||Sotorasib (AMG510) racemate
||Sotorasib (AMG510) racemate is a racemic of AMG-510 which is a potent KRAS G12C covalent inhibitor with potential antineoplastic activity.
||Sotrastaurin (AEB071) is a potent and selective pan-PKC inhibitor, mostly for PKCθ with Ki of 0.22 nM in a cell-free assay; inactive to PKCζ. Phase 2.
||SOX9 Rabbit Recombinant mAb
||SOX9 Rabbit Recombinant mAb detects endogenous levels of SOX9.
||SP-13786 (UAMC-1110)(compound 60) is a potent and selective inhibitor of fibroblast activation protein (FAP) and prolyl oligopeptidase (PREP) with IC50 of 3.2 nM and 1.8 μM, respectively.
||SP-96 is a potent, selective and non-ATP-competitive inhibitor of Aurora B with IC50 of 0.316 nM. SP-96 can be used for the research of triple negative breast cancer (TNBC).
||SP1 Rabbit Recombinant mAb
||SP1 Rabbit Recombinant mAb detects endogenous level of SP1.
||SP-141 is a specific MDM2 inhibitor. SP-141 promotes MDM2 auto-ubiquitination and degradation. SP-141 in potential for cancer research.
SP187 is a host-targeted iminosugar with activity against filovirus infections in vitro and in vivo.
||SP2509 (HCI-2509) is a selective histone demethylase LSD1 inhibitor with IC50 of 13 nM, showing no activity against MAO-A, MAO-B, lactate dehydrogenase and glucose oxidase. SP2509 induces apoptosis and promotes autophagy.
||SP600125 (Nsc75890) is a broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 40 nM, 40 nM and 90 nM in cell-free assays, respectively; 10-fold greater selectivity against MKK4, 25-fold greater selectivity against MKK3, MKK6, PKB, and PKCα, and 100-fold selectivity against ERK2, p38, Chk1, EGFR etc. SP600125 is also a broad‐spectrum inhibitor of serine/threonine kinases including Aurora kinase A，FLT3 and TRKA with of IC50 of 60 nM, 90 nM and 70 nM. SP600125 inhibits autophagy and activates apoptosis.
||Sparfloxacin (AT-4140, CI-978, PD 131501) is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity.
||Sparsentan (PS-433540, RE-021)
||Sparsentan (PS-433540, RE-021, DARA) is a dual endothelin type A receptor(ETA) and angiotensin II type 1 receptor antagonist.
||Spartalizumab (anti-PD-1) is a humanized anti-PD-1 IgG4 antibody that blocks the binding of PD-L1 and PD-L2 to PD-1. It binds to PD-1 with high affinity and inhibits the biological activity of PD-1, MW: 145.8 KD.
||Sparteine, which could be extracted from scotch broom, is a sodium channel blocker and a class 1a antiarrhythmic agent.
||Spastazoline is a potent, cell-permeable and selective spastin (a microtubule-severing AAA (ATPases associated with diverse cellular activities) protein) inhibitor with IC50 of 99 nM for Human spastin. Spastazoline does not inhibit ATPase activity of a recombinant human VPS4 (another AAA protein required for intercellular bridge disassembly).
||Spautin-1 is a potent and specific autophagy inhibitor, and inhibits the deubiquitinating activity of USP10 and USP13 with IC50 of ∼0.6-0.7 μM. Spautin-1 enhances apoptosis.
||SPDB is a glutathione cleavable ADC linker applied into the synthesis of antibody-drug conjugate (ADCs).
||SPDB-sulfo is a glutathione cleavable ADC linker applied into the synthesis the antibody-drug conjugates (ADCs).
||SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable disulfide bonds with cysteine sulfhydryls. SPDP is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs).
||SPDV is a cleavable ADC linker that can be applied into the diagnosis and treatment of cancer or B cell proliferative disease.
||Spebrutinib (CC-292, AVL-292) is a covalent, orally active, and highly selective BTK inhibitor with IC50 of <0.5 nM, displaying at least 1400-fold selectivity over the other kinases assayed. Phase 1.
||Specnuezhenide (Nuezhenide), one of the main ingredients of Chinese medicine, has anti-angiogenic and vision improvement effects.
||Spectinomycin 2HCl (Actinospectacin) is a new parenteral antibiotic prepared from Streptomyces spectabilis.
||Spectinomycin dihydrochloride pentahydrate
||Spectinomycin dihydrochloride pentahydrate (Trobicin) is a widely used antibiotic that inhibits bacterial protein synthesis by blocking translocation of messenger RNA and transfer RNAs on the ribosome.
||Spermidine is a natural polyamine that stimulates cytoprotective macroautophagy/autophagy.
||Spermidine (4-Azaoctamethylenediamine), a natural polyamine produced from putrescine and decarboxylated S-adenosylmethionine (dcSAM) by spermidine synthase, is a novel autophagy inducer and negatively modulates N-methyl-d-aspartate (NMDA).
||Spermine (4,9-Diaza-1,12-dodecanediamine) is a polyamine involved in cellular metabolism found in all eukaryotic cells. It is found in a wide variety of organisms and tissues and is an essential growth factor in some bacteria.
||Spermine (Gerontine, Neuridine, Musculamine) is a polyamine involved in cellular metabolism found in all eukaryotic cells. It is a major natural intracellular compound capable of protecting DNA from free radical attack.
||Sphingosine (2-amino-4-trans-octadecene-1,3-diol, C18 Sphingosine) is an 18-carbon amino alcohol with an unsaturated hydrocarbon chain, which forms a primary part of sphingolipids, a class of cell membrane lipids that include sphingomyelin, an important phospholipid.
||SPHINX31 is a SRPK1 inhibiror with an IC50 of 5.9 nM with highly selectivity for SRPK1 over SRPK2 (50-fold) and CLK1 (100-fold).
||SPI-112 is a not cell permeable inhibitor of Src homology region 2 domain-containing phosphatase 2 (SHP-2, PTPN11) with IC50 of 1 μM in cell-free assay.
||Spiculisporic acid (4,5-dicarboxy-4-pentadecanolide) is a bioactive γ-butenolide isolated from a marine Aspergillus.
||Spinosin (Flavoayamenin), a ﬂavone-C-glycoside, is a bioactive ingredient isolated from a traditional Chinese herb Zizyphi Spinosi Semen. It acts as a plant metabolite and an anxiolytic drug.
||Spiramycin (Formacidine) is a 16-membered ring macrolide (antibiotic).
||Spiramycin I (Foromacidin A) is a main component of spiramycin, which is a macrolide antimicrobial agent with broad spectrum antibiotic activity.
||Spironolactone is a potent antagonist of the androgen receptor with IC50 of 77 nM.
||SQ22536 (9-(tetrahydrofuran-2-yl)-9h-purin-6-amine) is an inhibitor of adenylyl cyclase with an IC50 of 1.4 μM. It can inhibit PGE1-stimulated increases in cAMP levels in intact human platelets.
||Squalane (Perhydrosqualene, Dodecahydrosqualene) is a naturally occuring lipid in both plants and animals. It is usually used as an emollient and moisturizer in cosmetics manufacturing.
||Squalene (Spinacene, Supraene, trans-Squalene), a naturally occurring substance found in plants, animals and humans, is a component of some adjuvants that is added to vaccines to enhance the immune response.
||SR 0987, a SR 1078 analog, is an agonist for T cell-specific RORγ (RORγt) with EC50 of 800 nM. SR 0987 represses PD-1, produces IL17 and is potential for the treatment of cancer.
||SR 19881 is a potent full agonist of ERRγ with EC50 of 0.39 μM and 4.7 μM in a binding assay and a cell-based assay, respectively. SR 19881 is also equipotent on ERRβ with EC50 of 0.63 μM making it an equipotent dual agonist of ERRβ/γ.
SR 57227A is a selective 5-HT3 receptor agonist which crosses the blood brain barrier.
||SR-12813 is a pregnane X receptor (PXR) agonist and HMG-CoA reductase inhibitor with an IC50 of 850 nM.
||SR-18292 inhibits PGC-1α gluconeogenic activity and reduces co-activation of HNF4α by modulating the interaction between GCN5 and PGC-1α.
||SR-3029 is a potent and selective casein kinase 1δ/1ε (CK1δ/ε) inhibitor with IC50 values of 44 and 260 nM for CK1δ and CK1ε, respectively.
||SR-4370 is a potent and selective inhibitor of class I HDACs with IC50 of 0.13 µM, 0.58 µM, 0.006 µM, 2.3 µM, 3.7 µM for HDAC 1, HDAC 2, HDAC 3, HDAC 8, HDAC 6, respectively.SR-4370 suppresses AR signaling and in vivo prostate tumor growth.
||SR-4835 is a highly selective dual inhibitor of CDK12 and CDK13 with IC50 of 99 nM and Kd of 98 nM for CDK12 and IC50 of 4.9 nM for CDK13. SR-4835 disables triple-negative breast cancer (TNBC) cells. SR-4835 promotes synergy with DNA-damaging chemotherapy and PARP inhibitors.
||SR-717 lithium is a non-nucleotide STING agonist that demonstrates broad interspecies and interallelic specificity with EC50 of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 (cGAS KO) cell lines, respectively. SR-717 lithium also induces the expression of clinically relevant targets, including programmed cell death 1 ligand 1 (PD-L1), in a STING-dependent manner. SR-717 lithium exhibits antitumor activity.
||SR1001 is a RORα inverse agonist with Ki values of 172 nM and 111 nM for RORα and RORγ respectively.
||SR1078, a synthetic ligand for RORα and RORγ, functions as a RORα/γ agonist.
SR15006 is potent inhibitor of colorectal cancer (CRC) cells growth in vitro.
||SR17018 is an agonist of mu-opioid-receptor (MOR) binding with GTPγS with EC50 of 97 nM.
||SR18662 is an optimized compund based on ML264 that inhibits Krüppel-like factor 5 (KLF5) with IC50 of 4.4 nM. SR18662 reduces the viability of multiple colorectal cancer cell lines. SR18662 induces apoptosis.
||SR3335 (ML-176) is a selective and inverse agonist of retinoic acid receptor-related receptor α (RORα) that directly binds to RORα with Ki of 220 nM.
SR33805 is a potent Ca2+ channel antagonist with EC50s of 4.1 nM and 33 nM in depolarized and polarized conditions, respectively. SR33805 blocks L-type but not T-type Ca2+ channels.
||SR59230A is a blood-brain barrier penetrating, potent and selective antagonist of β3-adrenergic receptor with IC50 of 40 nM, 408 nM, and 648 nM for β3, β1, and β2 receptors, respectively.
||SR8278 is a competitive antagonist of nuclear heme receptor REV-ERB with an EC50 of 0.47 μM for REV-ERBα.
||SR9243 is a potent and selective LXR inverse agonist.
||Src Inhibitor 1
||Src Inhibitor 1 is a potent competitive inhibitor of both Src and Lck (IC50 = 44 and 88 nM, respectively), as well as Csk and Yes.
||Src Rabbit Recombinant mAb
||Src Rabbit Recombinant mAb detects endogenous levels of total Src.
||SRI-011381 is a novel agonist of the TGF-beta signaling pathway for treatment of Alzheimer's disease.
SRI-29329 is a potent, specific inhibitor of CDC-like kinase (CLK) that targets CLK1, 2 and 4, respectively.
||SRPIN340 is a selective SRPK inhibitor with Ki of 0.89 μM for SRPK1, showing no significant inhibitory activity against more than 140 other kinases..
||SRS11-92 (AA9), a Ferrostatin-1 (Fer-1) analogue, is a potent inhibitor of ferroptosis. SRS11-92 inhibits ferroptotic cell death induced by Erastin in HT-1080 human fibrosarcoma cells with EC50 of 6 nM.
||SRS16-86, a novel third-generation ferrostatin, is an inhibitor of ferroptosis.
||SRT-1460 is a potent and selective activator of Sirtuin 1 (SIRT1) with EC1.5 of 2.9 μM. SRT-1460 reduces cell viability and growth of pancreatic cancer cells and induces apoptosis.
||SRT1720 HCl is a selective SIRT1 activator with EC50 of 0.16 μM in a cell-free assay, but is >230-fold less potent for SIRT2 and SIRT3. SRT1720 induces autophagy.
||SRT2104 (GSK2245840) is a selective SIRT1 activator involved in the regulation of energy homeostasis. Phase 2.
||SRT2183 is a small-molecule activator of the sirtuin subtype SIRT1, currently being developed by Sirtris Pharmaceuticals.
||SRT3025 is an orally available small molecule activator of the SIRT1 enzyme.
||SRX3207 is an orally active dual inhibitor of Syk-PI3K with IC50 of 39.9 nM, 31200 nM, 3070 nM, 3070 nM, 244 nM, 388 nM, 9790 nM for Syk, Zap70, BRD41, BRD42, PI3K alpha, PI3K delta, PI3K gamma, respectively. SRX3207 blocks tumor immunosuppression and increases anti-tumor immunity.
||SSD114 hydrochloride is a positive allosteric modulator (PAM) of GABAB receptor.
||SSR128129E is an orally-active and allosteric FGFR1 inhibitor with IC50 of 1.9 μM, while not affecting other related RTKs.
||ST271 is a tyrphostin-like protein tyrosine kinase (PTK) inhibitor which inhibits phospholipase D (PLD) activity.
||ST034307 is a potent and selective inhibitor of adenylyl cyclase 1 (AC1) with IC50 of 2.3 μM.
||Stachydrine (Proline betaine, L-stachydrine, Methyl hygrate betaine) is a quaternary ammonium derivative of proline that occurs widely in Medicago species. It is an osmoprotective compound found in urine. Stachydrine is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood circulation and dispel blood stasis. Stachydrine can inhibit the NF-κB signal pathway.
||Stachydrine is isolated from seed husk and the pulp of the fruit of C. Leonurus, and many other Asian plants and fruits. It has potent anti-metastatic activity and cardioprotective effects. Stachydrine hydrochloride is the major active constituent of Herba Leonuri, which is a potential therapy for cardiovascular diseases. Stachydrine can inhibit the NF-κB signal pathway. Anti-hypertrophic activities.
||Stachyose is a natural sugar found in many foods like beans and vegetables.
||STAT2 Rabbit Recombinant mAb
STAT2 Antibody detects endogenous levels of STAT2.
||STAT3-IN-1 (compound 7d) is an excellent, selective and orally active inhibitor of STAT3 with IC50 of 1.82 μM and 2.14 μM in HT29 and MDA-MB 231 cells, respectively. STAT3-IN-1 induces apoptosis of tumor cells.
||STAT4 Rabbit Recombinant mAb
STAT4 Antibody detects endogenous levels of STAT4.
||STAT5-IN-1 is a potent and selective STAT5 inhibitor with IC50 of 47 μM for STAT5β isoform.
||STAT5a Rabbit Recombinant mAb
STAT5a Antibody detects endogenous levels of total STAT5a.
||STAT5b Rabbit Recombinant mAb
STAT5b Rabbit Recombinant mAb detects endogenous levels of STAT5b.
||Stathmin 1 Rabbit Recombinant mAb
||Stathmin 1 Rabbit Recombinant mAb detects endogenous level of total Stathmin 1.
||Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM in cell-free assays, highly selectivity over STAT1. Stattic induces apoptosis.
||Staufen Rabbit Recombinant mAb
||Staufen Rabbit Recombinant mAb detects endogenous level of total Staufen.
||Staurosporine (AM-2282, Antibiotic AM-2282, STS) is a potent PKC inhibitor for PKCα, PKCγ and PKCη with IC50 of 2 nM, 5 nM and 4 nM, less potent to PKCδ (20 nM), PKCε (73 nM) and little active to PKCζ (1086 nM) in cell-free assays. Also shows inhibitory activities on other kinases, such as PKA, PKG, S6K, CaMKII, etc. Phase 3.
||Stavudine (d4T, BMY-27857, Sanilvudine, NSC 163661) is a nucleoside analog reverse transcriptase inhibitor (NARTI) active against HIV.
||Stearic acid (Octadecanoic acid, Isostearic acid, Cetylacetic acid) is a natural saturated fatty acid found in animal and vegetable fats. It could be used as a food additive and used in soaps, cosmetics and detergents.
||Stem Cell Differentation Compound Library
||A unique collection of 249 stem cell differentation related compounds used for high throughput screening(HTS) and high content screening(HCS).
||Stem Cell Signaling Compound Library
|| A unique collection of 870 compounds with biological activity used for stem cell regulatory and signaling pathway research.
||StemRegenin 1 (SR1)
||StemRegenin 1 (SR1) is an aryl hydrocarbon receptor (AhR) inhibitor with IC50 of 127 nM in a cell-free assay.
||Stenabolic (SR9009) is a synthetic REV-ERB agonist with IC50s of 670 nM and 800 nM for REV-ERB-α and for REV-ERB-β, respectively.
||Stenoparib (E7449, 2X-121, MGI25036) is an orally bioavailable, brain penetrable, small molecule dual inhibitor of PARP1/2 and also inhibits PARP5a/5b, otherwise known as tankyrase1 and 2 (TNKS1/2), important regulators of canonical Wnt/β-catenin signaling. It has IC50 values of 1.0 and 1.2 nM for PARP1 and 2, respectively.
||Steviol (Hydroxydehydrostevic acid)
||Steviol (Hydroxydehydrostevic acid, Hydroxy Dehydrostevic Acid, NSC 226902), a major metabolite of the sweetening compound stevioside, inhibits CFTR activity, reduces AQP2 expression and promotes AQP2 degradation.
||Steviolbioside (CCRIS-6025), a natural sweetener, exhibits moderate antituberculosis activity against M. tuberculosis strain H37RV in vitro.
||Stevioside is a natural sweetener extracted from leaves of Stevia rebaudiana (Bertoni) Bertoni.
||STF-31 is a selective glucose transporter GLUT1 inhibitor.
||STF-62247 is a molecule targeting VHL-deficient renal cell carcinoma that induces autophagy. STF-62247 shows selective toxicity and growth inhibition of renal cells lacking VHL; 25-fold greater sensitivity observed for cells with VHL deficiency compared to wild-type (VHL+).
||Stigmasterol is an unsaturated plant sterol that exhibits anti-cancer, anti-pyretic, anti-inflammatory and immune-modulating effects.
||STING agonist-1 (G10)
||STING agonist-1 (G10) is a novel human-specific STING agonist that triggers IFN regulatory factor 3 (IRF3)/ type I interferon (IFN)-associated transcription in human fibroblasts. STING agonist-1 (G10) potently reduces growth of Chikungunya virus (CHIKV) with IC90 of 8.01 μM and blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV) with IC90 of 24.57 μM.
||STING inhibitor C-178
||C-178 is a covalent inhibitor of STING,covalently bind to Cys91.
||Stiripentol (BCX2600) is a third-generation anti-epileptic drug that enhances GABAergic neurotransmission. It is an inhibitor of cytochrome P450.
||STK3 Rabbit Recombinant mAb
||STK3 Rabbit Recombinant mAb detects endogenous level of total STK3.
||STM2457 is a highly potent and selective first-in-class catalytic inhibitor of RNA Methyltransferase METTL3 with an IC50 of 16.9 nM. STM2457 is highly specific for METTL3 and showed no inhibition of other RNA methyltransferases.
||STO-609 is a specific inhibitor of the Ca2+/Calmodulin-dependent protein kinase kinase(CaM-KK) that inhibits the activities of recombinant CaM-KKα and CaM-KKβ isoforms, with Ki values of 80 and 15 ng/ml, respectively, and also inhibits their autophosphorylation activities. STO-609 inhibits AMPKK activity and inhibits autophagy.
||Streptomycin sulfate is a sulfate salt of streptomycin that is a protein synthesis inhibitor.
||Streptozotocin (STZ, NSC-85998, Streptozocin, U 9889) is a glucosamine-nitrosourea derivative, which is a DNA-methylating, carcinogenic, antibiotic and diabetes inducing agent. Streptozotocin induces autophagy and apoptosis. Solutions are best fresh-prepared.
||Strictosamide is the main representative constituent of Nauclea officinalis Pierre ex Pitard (Rubiaceae) with anti-inflammatory and analgesic activities.
||Strontium Ranelate is a strontium(II) salt of ranelic acid for (-)-desmethoxyverapamil binding to calcium channel with IC50 of 0.5 mM.
||Stylopine ((R,S)-Stylopine, Tetrahydrocoptisine) reduces nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), and the IL-6 production and cyclooxygenase-2 (COX-2) activity caused by the LPS stimulation. Stylopine is a major component of the leaf of Chelidonium majus L.
||Stylopine (Tetrahydrocoptisine, Coptisine), a major component of the leaf of Chelidonium majus L., is a protoberberine-type alkaloid that has potential biological activities, including anti-inflammatory activity.
||SU 4313 is a bioactive chemical.
||SU 4942 is a tyrosine kinase signal transduction modulator, targeting VEGF and ECGF.
||SU 5201 (NSC 247030) is an interleukin-2 (IL-2) inhibitor.
||SU-4984 is a cell-permeable, ATP-competitive and reversible inhibitor of the fibroblast growth factor receptor 1 (FGFR1).
||SU11274 (PKI-SU11274) is a selective Met (c-Met) inhibitor with IC50 of 10 nM in cell-free assays, no effects on PGDFRβ, EGFR or Tie2. SU11274 induces autophagy, apoptosis and cell cycle arrest.
||SU14813 (SU 014813) is a multiple receptor tyrosine kinase inhibitor with IC50 of 50 nM, 2 nM, 4 nM and 15 nM for VEGFR2, VEGFR1, PDGFRβ and Kit (c-Kit). SU14813 exhibits potent antiangiogenic and antitumor activity.
||SU1498, a powerful inhibitor of KDR (IC50 = 0.7 μM), stimulates accumulation of phosphorylated ERK1/2 in endothelial cells.
||SU5204 is a tyrosine kinase inhibitor with IC50 of 4 μM and 51.5 μM for FLK-1 (VEGFR-2) and HER2, respectively.
||SU5205 is an inhibitor of VEGF receptor 2 (VEGFR2/FLK-1) with IC50 of 9.6 µM.
||SU5208 is a bioactive compound.
||SU5214 is a inhibitor of VEGF receptor 2 (VEGFR2/FLK-1) with IC50 of 14.8 µM and EGFR with IC50 of 36.7 µm, respectively.
||SU5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC50 of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGF-Rβ, respectively.
||SU5408 (VEGFR2 Kinase Inhibitor I) is a potent and selective inhibitor of VEGFR2 Kinase with IC50 of 70 nM.
||SU5614 (Chloro-SU5416, Chloro-Semaxanib) is a small molecule receptor tyrosine kinases (RTK) inhibitor of VEGFR-2, c-kit, and both wild-type and mutant FLT3. SU5614 reduces cell proliferation and induces apoptosis.
||SU 6656 is a selective Src family kinase inhibitor with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively.
||SU 9516 is a 3-substituted indolinone CDK inhibitor with IC50 of 22 nM, 40 nM, and 200 nM for CDK2, CDK1, and CDK4, respectively.
||Subasumstat (TAK-981) is a novel, selective inhibitor of the SUMOylation enzymatic cascade with potential immune-activating and antineoplastic activities.
||Suberohydroxamic acid (suberic bishydroxamic acid) is a competitive HDAC inhibitor with IC50 values of 0.25 and 0.3 μM for HDAC1 and HDAC3 respectively.
||Succimer (DMSA, meso-2,3-dimercaptosuccinic acid) is an orally active metal chelator is used to treat heavy metal poisoning.
||Succinic acid (1,4-Butandioic Acid, 1,2-Ethanedicarboxylic acid, Amber acid, Asuccin, Butanedioic acid) is a crystalline organic acid which occurs in living tissue as an intermediate in glucose metabolism.
||Succinic anhydride (SA, Succinyl Oxide, Butanedioic Anhydride) is a cyclic anhydride that can be used in the homogeneous chemical modification of cellulose and as a noncleavable ADC linker that reacts with other compound to link the prodrug to an amine or hydroxy 1 group of a targeting polypeptide.
||Succinylcholine Chloride Dihydrate
||Succinylcholine Chloride Dihydrate (Suxamethonium) is a nicotinic AChR agonist and also acts as a depolarizing neuromuscular blocker.
||Succinylsulfathiazole (Succinylsulphathiazole), a sulfonamide, is an antibiotic.
||Sucralfate is a sucrose sulfate-aluminium complex that binds to the ulcer, creating a physical barrier that protects the gastrointestinal tract from stomach acid and prevents the degradation of mucus.
||Sucralose (E955) is an artificial and noncaloric sweetener, not broken down by the body.
||Sucrose (D-(+)-Saccharose), a common sugar produced naturally in plants, is a disaccharide, a molecule composed of two monosaccharides:glucose and fructose.
||Sudan I (C.I. Solvent Yellow 14) is an azo dye. It causes tumors in the liver or urinary bladder in rats, mice, and rabbits and may be a potential carcinogen for humans.
||Sudan II (Sudan Red II, Solvent Orange 7, Color Index No: 12140, C.I. 12140) is a lysochrome (fat-soluble dye) azo dye used for staining of triglycerides in frozen sections, and some protein bound lipids and lipoproteins on paraffin sections.
Sufugolix (TAK-013) is a highly potent luteinizing hormone-releasing hormone (LHRH) receptor antagonist with an IC50 of 0.1 nM.
||Sugammadex (ORG-25969) is a selective relaxant binding agent indicated for reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide during surgery in adults.
||Sulbactam is a beta-lactamase inhibitor with an average IC50 of 0.8 μM.
||Sulbactam sodium (Unasyn, CP-45899-2) is an irreversible β-lactamase inhibitor.
||Sulbenicillin Sodium (Sulfocillin, Sulfobenzylpenicillin) is the sodium salt of sulbenicillin, which is a penicillin antibiotic.
||Sulbutiamine is a synthetic derivative of thiamine (vitamin B1), belonging to a class of supplements shown to help improve memory, learning capacity, decision-making, concentration, and focus.
||Sulconazole Nitrate is an imidazole derivative with broad-spectrum antifungal activity.
||Sulfabenzamide (Sultrin, N-Sulfanilylbenzamide) is an antibacterial/antimicrobial which also exhibit their antitumor effects through multiple mechanisms including inhibition of membrane bound carbonic anhydrases, prevention of microtubule assembly, cell cycle arrest, and inhibition of angiogenesis.
||Sulfacetamide (Acetosulfamine) is a synthetic sulfanylacetamide derivative with bacteriostatic activity. It is an anti-infective agent that is used topically to treat skin infections and orally for urinary tract infections.
||Sulfacetamide Sodium is an anti-biotic.
||Sulfacetamide sodium salt hydrate
||Sulfacetamide is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase(DHPS) with IC50 of 9.5 μM. Sulfacetamide is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid.
||Sulfachloropyridazine is an antibiotic used to treat a variety of bacterial infections.
||Sulfadiazine is a sulfonamide antibiotic.
||Sulfadimethoxine (Sulfadimethoxydiazine) is a long-lasting sulfonamide antimicrobial agent used to treat many infections including treatment of respiratory, urinary tract, enteric, and soft tissue infections.
||Sulfadoxine (Sulphadoxine) is an ultra-long-lasting sulfonamide with an IC50 of 249 μg/ml for P. vivax.
||Sulfaguanidine is a sulfonamide used as an anti-infective agent.
||Sulfaisodimidine (Sulfamethin) is a sulfonamide antibacterial.
||Sulfalene (SMPZ, Butadiene sulfone, 3-Sulfolene) is a cyclic organic chemical used as a versatile synthetic intermediate.
||Sulfalozine sodium (Sulfaclozine sodium, Sulfachlopryrazine sodium) is an antiprotozoal useful in coccidiosis research.
||Sulfamerazine (RP 2632) is a sulfonamide antibacterial.
||Sulfameter is a long-acting sulfonamide antibacterial.
||Sulfamethazine is a sulfonamide antibacterial.
||Sulfamethazine Sodium Salt
||Sulfamethazine (Sulfadimethyldiazine) is a sulfanilamide anti-infective agent used in the lifestock industry.
||Sulfamethizole is a sulfathiazole antibacterial agent.
||Sulfamethoxazole is a sulfonamide bacteriostatic antibiotic with an IC50 of 2.7 μM.
||Sulfamethoxazole sodium is an antibiotic used for bacterial infections.
||Sulfamethoxypyridazine (CL 13494) is a long-acting sulfonamide for treatment of Dermatitis herpetiformis.
||Sulfamide (Sulfuric diamide) is used in organic chemistry for synthesis.
||Sulfamonomethoxine is a long-acting sulfonamide antibacterial agent and blocks the synthesis of folic acid by inhibiting synthetase of dihydropteroate.
||Sulfanilamide (Sulphanilamide) is a competitive inhibitor for bacterial enzyme dihydropteroate synthetase with IC50 of 320 μM.
||Sulfaphenazole (Depocid, Depotsulfonamide, Plisulfan, Raziosulfa) is an inhibitor of CYP2C9 with Ki value of 0.3 μM and demonstrates at least 100-fold selectivity over other CYP450 isoforms (Ki values of 63 and 29 μM for CYP2C8 and CYP2C18, respectively, and no activity at CYP1A1, CYP1A2, CYP3A4, CYP2C19).
||Sulfapyridine is a sulfonamide antibacterial.
||Sulfaquinoxaline sodium (N'1-quinoxalin-2-ylsulphanilamide sodium, SQ-Na) is the sodium salt of sulfaquinoxaline, which is often used as a drug to prevent coccidiosis in poultry, swine, and sheep by inhibiting the synthesis of nucleic acids and proteins in microorganisms.
||Sulfasalazine (NSC 667219)
||Sulfasalazine (NSC 667219, Azulfidine, Salazopyrin, Sulphasalazine) is a sulfa derivative of mesalazine, used as an anti-inflammatory agent to treat bowel disease and rheumatoid arthritis. Sulfasalazine is a potent and specific inhibitor of nuclear factor kappa B (NF-κB), TGF-β and COX-2. Sulfasalazine induces ferroptosis, apoptosis and autophagy.
||Sulfathiazole is an organosulfur compound that has been used as a short-acting sulfa drug.
||Sulfathiazole sodium, an antimicrobial agent, is an organosulfur compound that has been used as a short-acting sulfa drug.
||Sulfatinib (HMPL-012, Sufatinib, Surfatinib, Surufatinib) is a potent and highly selective tyrosine kinase inhibitor against VEGFR1, VEGFR2, VEGFR3, FGFR1 and CSF1R with IC50 of 2 nM, 24 nM, 1 nM, 15 nM and 4 nM, respectively. Sulfatinib shows encouraging antitumor activity and manageable toxicities in patients with advanced NETs.
||Sulfisoxazole (NU-445) is a sulfonamide antibacterial with an oxazole substituent.
||Sulfo-SMCC sodium is a commonly-used hetero-bifunctional, noncleavable ADC crosslinker with N-hydroxysuccinimide (NHS) ester and maleimide groups to react with primary amines and sulfhydryl groups, respectively.
||Sulfogaiacol (Guaiacolsulfonate) is a antitussive agent that is used for acute respiratory tract infections, cough and other conditions.
Sulfopin (PIN1-3) is a highly selective covalent inhibitor of Pin1 with a Ki of 17 nM in the FP assay. Sulfopin blocks Myc-driven tumor initiation and growth in vivo.
||Sulforaphane is a naturally occurring isothiocyanate derived from the consumption of cruciferous vegetables, such as broccoli, cabbage, and kale. It is an inducer of Nrf2. Sulforaphane is also an inhibitor of histone deacetylase (HDAC) and NF-κB. Sulforaphane increases heme oxygenase-1 (HO-1) and reduces the levels of reactive oxygen species (ROS). Sulforaphane induces cell cycle arrest and apoptosis.
||Sulforaphene promotes cancer cells apoptosis and inhibits migration via inhibiting EGFR, p-ERK1/2, NF‐κB and other signals. Sulforaphene exhibits inhibiting activity against velvetleaf seedlings. Sulforaphene is isolated from radish seeds.
||Sulforhodamine 101 (SR101) is a fluorescent dye and is widely used for astrocyte identification.
||Sulforhodamine B sodium salt
||Sulforhodamine B (SRB, Acid Red 52, Kiton Red 620) sodium salt is a protein-specific fluorescent dye that is utilized to quantitate cell expansion, growth, and migration.
||Sulindac is a non-steroidal COX inhibitor, which potently inhibits prostaglandin synthesis, used in the treatment of acute or chronic inflammatory conditions.
||Sulisobenzone (Benzophenone-4, Sungard) is an ingredient in some sunscreens which protects the skin from damage.
||Suloctidil, a sulfur-containing aminoalcohol showing to inhibit human platelet aggregation, is a peripheral vasodilator and a potential antifungal agent.
||Sulopenem (CP-70429) is an orally active, potent inhibitor of beta-lactamase. Sulopenem is a parenteral penem antibiotic with broad-spectrum activities against Gram-positive and Gram-negative bacteria.
||Sulphadimethoxine is a non-reducing glucuronide.
||Sulpiride (Dolmatil, Dobren, Sulpyrid, Aiglonyl, Dogmatil) is a dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid.
||Sultamicillin is a newly developed antibiotic in which ampicillin and the β-lactamase inhibitor sulbactam are linked as an ester.
||Sultamicillin Tosylate is the tosylate salt of the double ester of sulbactam plus ampicillin. Sulbactam is a semisynthetic beta-lactamase inhibitor which, in combination with ampicillin, extends the antibacterial activity of the latter to include some beta-lactamase-producing strains of bacteria that would otherwise be resistant.
||Sumatriptan Succinate (GR 43175) is a triptan sulfa drug containing a sulfonamide group for the treatment of migraine headaches.
||SUMO1 Rabbit Recombinant mAb
||SUMO1 Rabbit Recombinant mAb detects endogenous level of total SUMO1.
||Sumo2/3 Rabbit Recombinant mAb
||Sumo2/3 Rabbit Recombinant mAb detects endogenous level of total Sumo2/3.
||SUMO4 Rabbit Recombinant mAb
||SUMO4 Rabbit Recombinant mAb detects endogenous level of total SUMO4.
||Sunitinib (SU11248) is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit. Sunitinib is also a dose-dependent inhibitor of the autophosphorylation activity of IRE1α. Sunitinib induces autophagy and apoptosis.
||Sunitinib (SU11248) malate
||Sunitinib (SU11248) malate is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM in cell-free assays, and also inhibits c-Kit. Sunitinib Malate effectively inhibits autophosphorylation of Ire1α. Sunitinib Malate increases both death receptor and mitochondrial-dependent apoptosis.
||Super-TDU is an inhibitory peptide targeting YAP-TEADs interaction.
||Suplatast Tosylate (IPD-1151T, Suplatast Tosilate) is a novel capsular anti-asthmatic agent that suppresses both IgE production, IL-4 and IL-5 synthesis with IC50 above 100 μM.
||Suprofen is a dual COX-1/COX-2 inhibitor, used as a non-steroidal anti-inflammatory analgesic and antipyretic.
||SUZ12 Rabbit Recombinant mAb
||SUZ12 Rabbit Recombinant mAb detects endogenous level of total SUZ12.
||SW-044248 is a non-canonical Top1 inhibitor with a pattern of selective toxicity for NSCLC cells.
||SW155246 is a potent and selective DNMT1 (DNA methyltransferase 1) inhibitor with IC50 of 1.2 μM. SW155246 induces re-expression of the tumor suppressor geneRASSF1 in A549 cells.
||Sweroside, a bioactive herbal ingredient isolated from Fructus Corni, exhibits diverse biological activities, such as anti-fungal, anti-diabetic, anti-inflammatory, and anti-tumor effects.
||Swertiamarin (Swertiamaroside) is a common secoiridoid found among the members of Gentianaceae with anti-inflammatory, anticancer, hypoglycemic and hypolipidemic activities.
||SX-682 is an orally bioavailable small-molecule allosteric inhibitor of CXCR1 and CXCR2 that blocks tumor MDSC recruitment and enhances T cell activation and antitumor immunity.
||Synephrine (Oxedrine), a natural protoalkaloid in the extract of bitter orange and other citrus species, is commonly used for weight loss.
||SynephrineHCl (Oxedrine, p-Synephrine) is a sympathomimetic α-adrenergic receptor (AR) agonist.
||SYP-5 is an inhibitor of Hypoxia-inducible factor-1 (HIF-1) that suppresses tumor cell migration and invasion, as well as tumor angiogenesis.
||Syringaldehyde (Syringic aldehyde) is an organic compound that occurs naturally in trace amounts. It possesses worthy bioactive properties and is, therefore, used in pharmaceuticals, food, cosmetics, textiles, pulp and paper industries, and even in biological control applications. Syringaldehyde is a polyphenolic compound belonging to the group of flavonoids and is found in different plant species like Manihot esculenta and Magnolia officinalis. Syringaldehyde moderately inhibits COX-2 activity with an IC50 of 3.5 μg/mL. Anti-hyperglycemic and anti-inflammatory activities.
||Syringaresnol-4-O-beta-D-apiofuranosy is a natrual product isolated from the bark of Albizzia myriophylla.
||Syringic acid (NSC 2129, SYRA) is a potential antioxidant used in traditional Chinese medicine and is an emerging nutraceutical. It has potential anti-angiogenic, anti-glycating, anti-hyperglycaemic, neuroprotective, and memory-enhancing properties.
||Syrosingopine (Su-3118) is a dual MCT1 and MCT4 inhibitor with IC50 values of 2500nM and 40 nM in HAP1 cells, respectively.
||SZL P1-41 (compound #25) is a specific inhibitor of S-phase kinase-associated protein 2 (Skp2) that indeed binds to Skp2, prevents Skp2-Skp1 interaction and inhibits Skp2 SCF E3 ligase activity, which consequently suppresses survival of cancer cells and cancer stem cells. SZL P1-41 causes higher apoptosis rates in cancer cells.
[SER140]-PLP(139-151) is a polypeptide fragment of the lipid protein of myelin.
||α-santonin, a naturally occurring sesquiterpene lactone, is a potent antiparasitic agent.
||β-Sitosterol (SKF 14463, 22,23-Dihydrostigmasterol) is one of several phytosterols (plant sterols) with chemical structures similar to that of cholesterol.