ATP disodium

For research use only.

Catalog No.S1985 Synonyms: Adenosine-Triphosphate disodium, ATP disodium salt, Adenosine 5'-triphosphate

11 publications

ATP disodium Chemical Structure

CAS No. 987-65-5

ATP Disodium (Adenosine-Triphosphate disodium, ATP disodium salt, Adenosine 5'-triphosphate) is a disodium salt form of adenosine-triphosphate which is a multifunctional nucleoside triphosphate.

Selleck's ATP disodium has been cited by 11 publications

Purity & Quality Control

Biological Activity

Description ATP Disodium (Adenosine-Triphosphate disodium, ATP disodium salt, Adenosine 5'-triphosphate) is a disodium salt form of adenosine-triphosphate which is a multifunctional nucleoside triphosphate.
In vitro

ATP release and autocrine feedback through P2Y2 and A3 receptors provide signal amplification, controlling gradient sensing and migration of neutrophils. [1] ATP results in production of reactive oxygen species (ROS), which stimulates the phosphatidylinositol 3-kinase (PI3K) pathway and subsequent Akt and ERK1/2 activation. ATP-dependent ROS production and PI3K activation also stimulate transcription of genes required for an oxidative stress response. ATP-mediated ROS-dependent PI3K is required for activation of caspase-1 and secretion of IL-1beta and IL-18. [2] ATP potently stimulates TNF-alpha release, resulting from TNF-alpha mRNA expression in rat cultured brain microglia. ATP-induced TNF-alpha release is Ca(2+)-dependent, and a sustained Ca(2+) influx correlated with the TNF-alpha release in ATP-stimulated microglia. ATP-induced TNF-alpha release is inhibited by PD 098059, an inhibitor of extracellular signal-regulated protein kinase (ERK) kinase 1 (MEK1), which activates ERK, and also by SB 203580, an inhibitor of p38 mitogen-activated protein kinase. ATP rapidly activates both ERK and p38 even in the absence of extracellular Ca(2+). [3] ATP-induced cytotoxicity is mediated by classical alterations of apoptosis, including membrane blebbing, nuclear condensation, and DNA fragmentation. ATP but not other nucleotides lead to the potent and selective activation of NF-κB in microglial cells through a P2Z receptor-mediated pathway. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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... Click to View More Cell Line Experimental Data

In vivo

ATP regulates microglial branch dynamics in the intact mice brain, and its release from the damaged tissue and surrounding astrocytes mediates a rapid microglial response towards injury. [5]

Protocol

Solubility (25°C)

In vitro Water 100 mg/mL (181.44 mM)
DMSO Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 551.14
Formula

C10H14N5O13P3.2Na

CAS No. 987-65-5
Storage powder
in solvent
Synonyms Adenosine-Triphosphate disodium, ATP disodium salt, Adenosine 5'-triphosphate
Smiles C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)OP(=O)([O-])OP(=O)(O)[O-])O)O)N.[Na+].[Na+]

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
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Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04987879 Not yet recruiting Behavioral: Exercise NAFLD Milton S. Hershey Medical Center December 2021 Not Applicable
NCT05031780 Not yet recruiting Drug: Mitapivat|Other: Mitapivat-matching placebo Sickle Cell Disease Agios Pharmaceuticals Inc. December 2021 Phase 2|Phase 3
NCT04760860 Not yet recruiting Drug: Terazosin Hydrochloride|Other: Placebo Dementia With Lewy Bodies Qiang Zhang|University of Iowa October 2021 Phase 1|Phase 2
NCT04902833 Not yet recruiting Procedure: Blood Draw Pyruvate Kinase Deficiency|Pyruvate Kinase Deficiency Anemia|Hereditary Hemolytic Anemia|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Neoplasm|Clonal Myeloid Neoplasm|Myeloproliferative Neoplasm|Acute Myeloid Leukemia|Clonal Cytopenia of Undetermined Significance|Other Clonal Myeloid Neoplasm|Unexplained Coombs-negative Non-immune Hemolytic Anemia Massachusetts General Hospital|Agios Pharmaceuticals Inc. October 2021 --
NCT04770779 Not yet recruiting Drug: Placebo Matching Mitapivat|Drug: Mitapivat Transfusion-dependent Alpha-Thalassemia|Transfusion-dependent Beta-Thalassemia Agios Pharmaceuticals Inc. September 2021 Phase 3
NCT04770753 Not yet recruiting Drug: Placebo Matching Mitapivat|Drug: Mitapivat Non-Transfusion-dependent Alpha-Thalassemia|Non-Transfusion-dependent Beta-Thalassemia Agios Pharmaceuticals Inc. September 2021 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID