For research use only.
Catalog No.S1368 Synonyms: Etretin, RO 10-1670
CAS No. 55079-83-9
Acitretin (Etretin, RO 10-1670) is a second generation retinoid used for psoriasis.
Selleck's Acitretin has been cited by 2 publications
2 Customer Reviews
Acitretin does not induce HIV reactivation in J-lat and ACH-2 cells. (a, b) HIV reactivation induced by acid retinoic (AR) derivative acitretin (25 – 1 μM) in J-Lat cells clone 8.4 (a) and 9.2(b). HDAC inhibitors (HDCAi) panobinostat (PNB, 0.16μM) and vorinostat (VOR, 4 – 0.16 μM) were used as controls. Reactivation was determined by the quantification of GFP+ cells (%) after culturing J-Lat with HDACi and acitretin for 24h. (c, d) HIV reactivation induced by acitretin and HDACi in ACH-2 cells. Reactivation was determined after 48h of incubation by quantification of CAp24 (c) and HIV RNA copy number (d) in the supernatant. Values represent mean±SD of at least three independent experiments performed in triplicate. UN, untreated. *P < 0.05; **P < 0.01; ***P < 0.001.
Antimicrob Agents Chemother, 2016, 61(11). pii: e01368-17. Acitretin purchased from Selleck.
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|Description||Acitretin (Etretin, RO 10-1670) is a second generation retinoid used for psoriasis.|
Acitretin stimulates ADAM10 promoter activity with an EC(50) of 1.5 mM and leads to an increase of mature ADAM10 protein that results in a two- to three-fold increase of the ratio between alpha- and beta-secretase activity in neuroblastoma cells.  Acitretin (5-20 μM) impairs mitochondrial phosphorylation efficiency as demonstrated by the decrease in the state 3 respiration and ATP levels, and by the increase in the lag phase of ADP phosphorylation cycle, without affecting the membrane potential. Acitretin induces Ca(2+)-mediated mitochondrial permeability transition (MPT) and decreased the adenine nucleotide translocase (ANT) content.  Acitretin preferentially inhibits the growth of SCL-1 cells in a dose- and time-dependent manner, but not of non-malignant keratinocyte HaCaT cells. Acitretin increases the levels of CD95 (Fas), CD95-ligand and Fas-associated death domain. Acitretin is able to induce apoptosis in skin cancer cells possibly via death receptor CD95 apoptosis pathway without affecting the viability of normal keratinocyte. 
|In vivo||Acitretin undergoes alpha-oxidation, chain shortening O-demethylation, and glucuronidation in the perfused rat liver.  Acitretin rapidly appears in liver and muscle of rats, where it undergoes redistribution into skin and adipose tissue. |
-  Tippmann F, et al. FASEB J, 2009, 23(6), 1643-1654.
-  Silva FS, et al. Toxicology, 2013, 306, 93-100.
-  Lin XY, et al. J Cell Mol Med, 2009, 13(9A), 2888-2898.
|In vitro||DMSO||20 mg/mL (61.26 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Synonyms||Etretin, RO 10-1670|
In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
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|Step 2: Enter the in vivo formulation ()|
|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
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Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04841187||Not yet recruiting||--||Psoriasis||Assistance Publique - Hôpitaux de Paris|Société de Dermatologie Française||April 1 2021||--|
|NCT04245319||Recruiting||Drug: Acitretin|Other: Narrow band ultraviolet B||Hyperlipidemias|Xerosis|Depression|Liver Diseases||Cairo University||January 1 2020||Not Applicable|
|NCT01039142||Completed||Drug: Acitretin||Psoriasis||Postgraduate Institute of Medical Education and Research||March 2008||Phase 4|
|NCT00488384||Withdrawn||Drug: Chemopreventive application (Acitretin)||Carcinoma Squamous Cell||Günther Hofbauer|University of Zurich||June 2007||Phase 4|
|NCT00156247||Completed||Drug: acitretin||Psoriasis||University of Medicine and Dentistry of New Jersey|Connetics Corp.|Rutgers The State University of New Jersey||September 2005||Phase 2|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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