Catalog No.S5552 Synonyms: ASP2151
Molecular Weight(MW): 482.55
Amenamevir is a potent helicase-primase inhibitor and a novel class of antiviral agent.
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|Description||Amenamevir is a potent helicase-primase inhibitor and a novel class of antiviral agent.|
ASP2151 inhibited the in vitro replication of HSV-1. The mean EC50s of ASP2151 against HSV-1 and HSV-2 were 14 (range, 7.7 to 20) and 30 ng/ml (range, 15 to 58), respectively.
|In vivo||In the cutaneously HSV-1-infected mouse model, ASP2151 dose dependently suppressed intradermal HSV-1 growth, with the effect reaching a plateau at a dose of 30 mg/kg of body weight/day.|
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02223351||Completed||Drug: ASP2151|Drug: ritonavir||Healthy||Maruho Europe Limited||September 2014||Phase 1|
|NCT00487682||Completed||Drug: ASP2151|Drug: Valacyclovir hydrochloride||Herpes Zoster||Astellas Pharma Inc||November 13 2007||Phase 2|
|NCT00486200||Completed||Drug: ASP2151|Drug: valacyclovir|Drug: Placebo||Herpes Genitalis||Astellas Pharma Inc||June 21 2007||Phase 2|
|NCT02796118||Completed||Drug: ASP2151|Drug: Placebo||Healthy Subjects||Astellas Pharma Inc||July 2006||Phase 1|
|NCT02852876||Completed||Drug: ASP2151|Drug: Placebo||Herpes Genitalis|Herpes Zoster||Astellas Pharma Europe Ltd.|Astellas Pharma Inc||September 2005||Phase 1|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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