For research use only.

Catalog No.S5552 Synonyms: ASP2151

1 publication

Amenamevir Chemical Structure

CAS No. 841301-32-4

Amenamevir (ASP2151) is a potent helicase-primase inhibitor and a novel class of antiviral agent.

Selleck's Amenamevir has been cited by 1 publication

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Biological Activity

Description Amenamevir (ASP2151) is a potent helicase-primase inhibitor and a novel class of antiviral agent.
helicase-primase [1]
In vitro

ASP2151 inhibited the in vitro replication of HSV-1. The mean EC50s of ASP2151 against HSV-1 and HSV-2 were 14 (range, 7.7 to 20) and 30 ng/ml (range, 15 to 58), respectively[2].

In vivo In the cutaneously HSV-1-infected mouse model, ASP2151 dose dependently suppressed intradermal HSV-1 growth, with the effect reaching a plateau at a dose of 30 mg/kg of body weight/day[2].


Animal Research:


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  • Animal Models: HSV-1-infected mice
  • Dosages: 1, 3, 10, 30, or 100 mg/kg/day
  • Administration: oral
    (Only for Reference)

Solubility (25°C)

Chemical Information

Molecular Weight 482.55


CAS No. 841301-32-4
Storage powder
in solvent
Synonyms ASP2151
Smiles CC1=C(C(=CC=C1)C)N(CC(=O)NC2=CC=C(C=C2)C3=NOC=N3)C(=O)C4CCS(=O)(=O)CC4

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Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02223351 Completed Drug: ASP2151|Drug: ritonavir Healthy Maruho Europe Limited September 2014 Phase 1
NCT00487682 Completed Drug: ASP2151|Drug: Valacyclovir hydrochloride Herpes Zoster Astellas Pharma Inc November 13 2007 Phase 2
NCT00486200 Completed Drug: ASP2151|Drug: valacyclovir|Drug: Placebo Herpes Genitalis Astellas Pharma Inc June 21 2007 Phase 2
NCT02796118 Completed Drug: ASP2151|Drug: Placebo Healthy Subjects Astellas Pharma Inc July 2006 Phase 1
NCT02852876 Completed Drug: ASP2151|Drug: Placebo Herpes Genitalis|Herpes Zoster Astellas Pharma Europe Ltd.|Astellas Pharma Inc September 2005 Phase 1

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID