Amenamevir

Catalog No.S5552 Synonyms: ASP2151

Amenamevir Chemical Structure

Molecular Weight(MW): 482.55

Amenamevir is a potent helicase-primase inhibitor and a novel class of antiviral agent.

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Biological Activity

Description Amenamevir is a potent helicase-primase inhibitor and a novel class of antiviral agent.
Targets
helicase-primase [1]
()
In vitro

ASP2151 inhibited the in vitro replication of HSV-1. The mean EC50s of ASP2151 against HSV-1 and HSV-2 were 14 (range, 7.7 to 20) and 30 ng/ml (range, 15 to 58), respectively[2].

In vivo In the cutaneously HSV-1-infected mouse model, ASP2151 dose dependently suppressed intradermal HSV-1 growth, with the effect reaching a plateau at a dose of 30 mg/kg of body weight/day[2].

Protocol

Animal Research:

[2]

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  • Animal Models: HSV-1-infected mice
  • Formulation: polyethylene glycol 400 [PEG 400]
  • Dosages: 1, 3, 10, 30, or 100 mg/kg/day
  • Administration: oral
    (Only for Reference)

Solubility (25°C)

Chemical Information

Molecular Weight 482.55
Formula

C24H26N4O5S

CAS No. 841301-32-4
Storage powder
in solvent
Synonyms ASP2151

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02223351 Completed Drug: ASP2151|Drug: ritonavir Healthy Maruho Europe Limited September 2014 Phase 1
NCT00487682 Completed Drug: ASP2151|Drug: Valacyclovir hydrochloride Herpes Zoster Astellas Pharma Inc November 13 2007 Phase 2
NCT00486200 Completed Drug: ASP2151|Drug: valacyclovir|Drug: Placebo Herpes Genitalis Astellas Pharma Inc June 21 2007 Phase 2
NCT02796118 Completed Drug: ASP2151|Drug: Placebo Healthy Subjects Astellas Pharma Inc July 2006 Phase 1
NCT02852876 Completed Drug: ASP2151|Drug: Placebo Herpes Genitalis|Herpes Zoster Astellas Pharma Europe Ltd.|Astellas Pharma Inc September 2005 Phase 1

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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