Afloqualone

Catalog No.S3663 Synonyms: HQ-495

For research use only.

Afloqualone (AFQ, HQ-495) is a quinazolinone family GABAergic drug with muscle-relaxant and sedative effects, showing the agonist activity at the β subtype of the GABAa receptor.

Afloqualone Chemical Structure

CAS No. 56287-74-2

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Biological Activity

Description Afloqualone (AFQ, HQ-495) is a quinazolinone family GABAergic drug with muscle-relaxant and sedative effects, showing the agonist activity at the β subtype of the GABAa receptor.
Targets
GABAA β receptor [2]
In vitro

Afloqualone inhibits vestibular nystagmus probably due to both inhibition of selective polysynaptic transmission and enhancement of the effects of GABA and glycine in the lateral vestibular nucleus (LVN), and its GABA-enhancing effect is thought to be attributable to the increased sensitivity of GABA receptors of the LVN neuron site[1].

Protocol (from reference)

Animal Research:[1]
  • Animal Models: Cats
  • Dosages: 2, 5, 10 mg/kg
  • Administration: p.o.

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 283.30
Formula

C16H14FN3O

CAS No. 56287-74-2
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=CC=CC=C1N2C(=NC3=C(C2=O)C=C(C=C3)N)CF

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