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Azvudine HIV Protease inhibitor

Name: Azvudine
Brand: Selleck Chemicals
SKU: E1243
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.E1243

Azvudine (RO-0622) is a novel nucleoside reverse transcriptase inhibitor with antiviral activity against human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV), potently inhibits HIV-1 (EC50 range 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM).

Chemical Structure

Molecular Weight: 286.22

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: E124301 DMSO]57 mg/mL]false]Water]57 mg/mL]false]Ethanol]57 mg/mL]false Purity: 99.86%

99.86

Related Targets	Bacterial Antibiotics Anti-infection Fungal Antiviral COVID-19 Parasite Reverse Transcriptase HIV HCV Protease SARS-CoV Influenza Virus β-lactamase Integrase HBV CMV Neuraminidase HCV HSV RSV Enterovirus Thioredoxin Reductase 3C-Like Protease Ribosomal Peptidyl Transferase HPV
Related Products	Pepstatin A Limonin Temsavir (BMS-626529)

Chemical Information, Storage & Stability

Molecular Weight	286.22	Formula	C₉H₁₁FN₆O₄	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	1011529-10-4	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Solubility

In vitro
Batch:

DMSO : 57 mg/mL ( (199.14 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 57 mg/mL

Ethanol : 57 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	2.850mg/ml (9.96mM)	Taking the 1 mL working solution as an example, add 50 μL of 57 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.470mg/ml (1.64mM)	Taking the 1 mL working solution as an example, add 50 μL of 9.4 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC₅₀/Ki	HIV-1 ^[1] (in antiviral activity assays) 0.03~ 6.92 nM(EC50) HIV-2 ^[1] (in antiviral activity assays) 0.018~ 0.025 nM(EC50) HBV ^[1] HCV ^[1]
References	https://pubmed.ncbi.nlm.nih.gov/25144636/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT05689034	Not yet recruiting	COVID-19 Respiratory Infection	Peking Union Medical College Hospital	January 20 2023	Phase 2\|Phase 3
NCT05033145	Completed	COVID-19	HRH Pharmaceuticals Limited\|GALZU INSTITUTE OF RESEARCH TEACHING SCIENCE AND APPLIED TECHNOLOGY Brazil\|Clinical Research Unit / High Complexity Center (CRU/HCC) / Galzu Institute	January 15 2022	Phase 3
NCT04668235	Completed	COVID-19	HRH Pharmaceuticals Limited\|GALZU INSTITUTE OF RESEARCH TEACHING SCIENCE AND APPLIED TECHNOLOGY Brazil\|UNIVERSIDADE ESTADUAL DO NORTE FLUMINENSE (UENF) Brazil	April 23 2021	Phase 3

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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