Catalog No.S5434 Synonyms: 3-Methylpyrazole-5-carboxylic acid

For research use only.

AS057278 (3-Methylpyrazole-5-carboxylic acid, MPC) is an inhibitor of D-amino acid oxidase (DAAO).

AS057278 Chemical Structure

CAS No. 402-61-9

Purity & Quality Control

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Biological Activity

Description AS057278 (3-Methylpyrazole-5-carboxylic acid, MPC) is an inhibitor of D-amino acid oxidase (DAAO).
DAAO [2]
0.91 μM
In vitro

No inhibitory effect on DASOX were observed with AS057278 at the concentration of 10 μM and no inhibitory effect on serine racemase were observed with AS057278 at the concentration of 50 μM[2].

In vivo MPC is able to increase brain d-serine levels and ameliorate PCP-induced abnormal behavior in SD rat[1]. MPC increaseS D-serine fraction in rat cortex and midbrain (10 mg/kg i.v.). AS057278 was able to normalize phencyclidine (PCP)-induced prepulse inhibition after acute (80 mg/kg) and chronic (20 mg/kg b.i.d.) oral administration in mice. AS057278 after oral chronic treatment (10 mg/kg b.i.d.) was able to normalize PCP-induced hyperlocomotion[2].

Protocol (from reference)

Animal Research:


  • Animal Models: Male SD rats
  • Dosages: 5.0 or 50 mg/kg
  • Administration: i.p.

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 126.11


CAS No. 402-61-9
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=CC(=NN1)C(=O)O

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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