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AS057278

Cat.No.S5434

AS057278 (3-Methylpyrazole-5-carboxylic acid, MPC) is an inhibitor of D-amino acid oxidase (DAAO).
AS057278 Chemical Structure

Chemical Structure

Molecular Weight: 126.11

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: S543401 DMSO]25 mg/mL]false]]]false]]]false Purity: 99.96%
99.96

Solubility

In vitro
Batch:

DMSO : 25 mg/mL (198.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
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In vivo Formulation Calculator (Clear solution)

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 126.11 Formula

C5H6N2O2

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 402-61-9 -- Storage of Stock Solutions

Synonyms 3-Methylpyrazole-5-carboxylic acid Smiles CC1=CC(=NN1)C(=O)O

Mechanism of Action

Targets/IC50/Ki
DAAO [2]
0.91 μM
In vitro
No inhibitory effect on DASOX were observed with AS057278 at the concentration of 10 μM and no inhibitory effect on serine racemase were observed with this compound at the concentration of 50 μM[2].
In vivo
MPC is able to increase brain d-serine levels and ameliorate PCP-induced abnormal behavior in SD rat[1]. MPC increaseS D-serine fraction in rat cortex and midbrain (10 mg/kg i.v.). This compound was able to normalize phencyclidine (PCP)-induced prepulse inhibition after acute (80 mg/kg) and chronic (20 mg/kg b.i.d.) oral administration in mice. It was able to normalize PCP-induced hyperlocomotion after oral chronic treatment (10 mg/kg b.i.d.)[2].
References

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