AZD5069

For research use only. Not for use in humans.

Catalog No.S6645

AZD5069 Chemical Structure

Molecular Weight(MW): 476.52

AZD5069 is a novel antagonist of CXCR2, which is shown to inhibit binding of CXCL8 to CXCR2 with a pIC50 value of 8.8 and inhibit CXCL8 binding to CXCR1 with pIC50 values of 6.5.

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Biological Activity

Description AZD5069 is a novel antagonist of CXCR2, which is shown to inhibit binding of CXCL8 to CXCR2 with a pIC50 value of 8.8 and inhibit CXCL8 binding to CXCR1 with pIC50 values of 6.5.
Targets
CXCR2 [1]
()
In vitro

AZD5069 is a slowly reversible antagonist of CXCR2 with effects of time and temperature evident on the pharmacology and binding kinetics[1].

In vivo

In preclinical models, airway neutrophil recruitment in response to inflammatory challenge is abrogated by selective targeting of CXCR2 using AZD5069[2].

Protocol

Solubility (25°C)

In vitro DMSO 95 mg/mL (199.36 mM)
Ethanol 7 mg/mL (14.68 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 476.52
Formula

C18H22F2N4O5S2

CAS No. 878385-84-3
Storage powder
in solvent
Synonyms N/A
Smiles CC(OC1=NC(=NC(=C1)N[S](=O)(=O)N2CCC2)SCC3=C(F)C(=CC=C3)F)C(O)CO

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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CXCR Signaling Pathway Map

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