Alverine Citrate

For research use only.

Catalog No.S3054 Synonyms: NSC 35459

1 publication

Alverine Citrate Chemical Structure

Molecular Weight(MW): 473.56

Alverine citrate is a drug used for functional gastrointestinal disorders. Alverine citrate is a 5-HT1A receptor antagonist, with an IC50 of 101 nM.

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Selleck's Alverine Citrate has been cited by 1 publication

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Biological Activity

Description Alverine citrate is a drug used for functional gastrointestinal disorders. Alverine citrate is a 5-HT1A receptor antagonist, with an IC50 of 101 nM.
In vitro

In pharmacological studies, alverine citrate has been shown to exert an effect on intestinal motility and intestinal sensitivity, two factors recognized as involved in the onset of FBD, without exhibiting the potential drawbacks of a medication with systemic effects.Alverine citrate affects basal and stimulated motility via a calcium-dependent and -independent inhibition of neuronal excitability as well as direct inactivation of L-type Ca2+ of smooth muscle cells. Experimental findings support an antinociceptive action by selective receptor-mediated mechanisms.

Protocol

Solubility (25°C)

In vitro DMSO 95 mg/mL (200.6 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 473.56
Formula

C20H27N.C6H8O7

CAS No. 5560-59-8
Storage powder
in solvent
Synonyms NSC 35459
Smiles CCN(CCCC1=CC=CC=C1)CCCC2=CC=CC=C2.OC(=O)CC(O)(CC(O)=O)C(O)=O

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5-HT Receptor Signaling Pathway Map

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