Alverine Citrate

Catalog No.S3054 Synonyms: NSC 35459

For research use only.

Alverine citrate (NSC 35459) is a drug used for functional gastrointestinal disorders. Alverine citrate is a 5-HT1A receptor antagonist, with an IC50 of 101 nM.

Alverine Citrate Chemical Structure

CAS No. 5560-59-8

Selleck's Alverine Citrate has been cited by 1 Publication

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Biological Activity

Description Alverine citrate (NSC 35459) is a drug used for functional gastrointestinal disorders. Alverine citrate is a 5-HT1A receptor antagonist, with an IC50 of 101 nM.
In vitro

In pharmacological studies, alverine citrate has been shown to exert an effect on intestinal motility and intestinal sensitivity, two factors recognized as involved in the onset of FBD, without exhibiting the potential drawbacks of a medication with systemic effects.Alverine citrate affects basal and stimulated motility via a calcium-dependent and -independent inhibition of neuronal excitability as well as direct inactivation of L-type Ca2+ of smooth muscle cells. Experimental findings support an antinociceptive action by selective receptor-mediated mechanisms.

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 473.56
Formula

C20H27N.C6H8O7

CAS No. 5560-59-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCN(CCCC1=CC=CC=C1)CCCC2=CC=CC=C2.C(C(=O)O)C(CC(=O)O)(C(=O)O)O

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