Name: Amoxicillin
Brand: Selleck Chemicals
SKU: S3015
Availability: InStock
Rating: 5 (5 reviews)

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Quality Control

Batch: Purity: 99.69%

99.69

Related Targets	Integrase Antibiotics Anti-infection Fungal Antiviral COVID-19 Parasite Reverse Transcriptase HIV HCV Protease
Other Bacterial Inhibitors	Berberine BTZ043 Racemate Teicoplanin Ornidazole Skatole Berberine Sulfate Pipemidic acid Ceftiofur PBTZ169 Aminothiazole

Solubility

In vitro
Batch:

DMSO : 73 mg/mL (199.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

%

% Tween 80

% ddH₂O

% DMSO

+

%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	365.4	Formula	C₁₆H₁₉N₃O₅S	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	26787-78-0	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	Amoxycillin			Smiles	CC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=C(C=C3)O)N)C(=O)O)C

Mechanism of Action

In vitro

Amoxicillin treated cells secrete high amounts of interleukin-5 and mostly lower or no amounts of tumor necrosis factor alpha, interleukin-4, and interferon-gamma. This compound-specific T cell clones fails to show drug-specific cytotoxicity, but killed target cells in the presence of concanavalin A, indicating a principal ability to be cytolytic. It releases faster in pH 1.0 hydrochloric acid (HCl) than in pH 7.8 phosphate buffer. The chemical would be degraded to some extent in a pH 1.0 HCl medium at 37 degrees C, which indicated that it is not stable in an acidic surrounding. It inhibits 4 of 15 isolates at 8 mg/mL or less but is not bactericidal against any of the isolates at that concentration. This compound in combination with clavulanic acid is bactericidal for 14 of 15 isolates tested at an amoxicillin concentration of 4 mg/mL or less and a clavulanic acid concentration of 2 mg/mL or less. It inhibits 50% of isolates tested decreased from 0.5 mg/mL (range, 0.25 to 1 mg/mL) to 0.06 mg/mL (range, 0.01 to 0.25 mg/mL) in the presence of only 4 mg of cefotaxime per mL.

References

[1] https://pubmed.ncbi.nlm.nih.gov/10998137/
[2] https://pubmed.ncbi.nlm.nih.gov/15653140/
[3] https://pubmed.ncbi.nlm.nih.gov/6416162/

[4] https://pubmed.ncbi.nlm.nih.gov/8540703/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT05464615	Recruiting	Penicillin Allergy	Geisinger Clinic	March 4 2024	Early Phase 1
NCT04408508	Not yet recruiting	Penicillin Allergy	Saskatchewan Health Authority - Regina Area	December 2023	Not Applicable
NCT05309928	Recruiting	Pregnancy Related	University of Alabama at Birmingham	August 29 2023	Phase 1
NCT05584683	Recruiting	Pediatric\|Bacterial Infections	Kaizen Bioscience Co.	August 9 2023	Phase 1
NCT05340257	Not yet recruiting	Infections Bacterial	GlaxoSmithKline	June 23 2023	Phase 2

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Amoxicillin Bacterial chemical

Chemical Structure

Molecular Weight: 365.4