Amoxicillin

Catalog No.S3015 Synonyms: Amoxycillin

For research use only.

Amoxicillin (Amoxycillin) is a moderate-spectrum, bacteriolytic, β-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms.

Amoxicillin Chemical Structure

CAS No. 26787-78-0

Selleck's Amoxicillin has been cited by 3 Publications

Purity & Quality Control

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Biological Activity

Description Amoxicillin (Amoxycillin) is a moderate-spectrum, bacteriolytic, β-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms.
In vitro

Amoxicillin treated cells secrete high amounts of interleukin-5 and mostly lower or no amounts of tumor necrosis factor alpha, interleukin-4, and interferon-gamma. Amoxicillin-specific T cell clones fails to show drug-specific cytotoxicity, but killed target cells in the presence of concanavalin A, indicating a principal ability to be cytolytic. [1] Amoxicillin releases faster in pH 1.0 hydrochloric acid (HCl) than in pH 7.8 phosphate buffer. Amoxicillin would be degraded to some extent in a pH 1.0 HCl medium at 37 degrees C, which indicated that amoxicillin is not stable in an acidic surrounding. [2] Amoxicillin inhibits 4 of 15 isolates at 8 mg/mL or less but is not bactericidal against any of the isolates at that concentration. Amoxicillin in combination with clavulanic acid is bactericidal for 14 of 15 isolates tested at an amoxicillin concentration of 4 mg/mL or less and a clavulanic acid concentration of 2 mg/mL or less. [3] Amoxicillin inhibits 50% of isolates tested decreased from 0.5 mg/mL (range, 0.25 to 1 mg/mL) to 0.06 mg/mL (range, 0.01 to 0.25 mg/mL) in the presence of only 4 mg of cefotaxime per mL. [4]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 365.4
Formula

C16H19N3O5S

CAS No. 26787-78-0
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=C(C=C3)O)N)C(=O)O)C

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05340257 Not yet recruiting Drug: Augmentin ES Infections Bacterial GlaxoSmithKline January 30 2023 Phase 2
NCT05309928 Not yet recruiting Drug: Amoxicillin Syphilis Congenital University of Alabama at Birmingham September 1 2022 Phase 1
NCT05464615 Not yet recruiting Drug: Amoxicillin Penicillin Allergy Geisinger Clinic August 1 2022 Early Phase 1
NCT05051787 Recruiting Biological: Blood and milk samples Breast Feeding Exclusive University Hospital Toulouse June 23 2022 Phase 4
NCT04408508 Not yet recruiting Drug: Amoxicillin 250 MG Penicillin Allergy Saskatchewan Health Authority - Regina Area March 2022 Not Applicable
NCT05010304 Recruiting Drug: Amoxicillin Penicillin Allergy|Penicillin Reaction University of Texas Southwestern Medical Center|American College of Allergy Asthma and Immunology December 9 2021 Phase 4

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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