Name: Amoxicillin
Brand: Selleck Chemicals
SKU: S3015
Availability: InStock
Rating: 5 (8 reviews)

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Quality Control

Batch: Purity: 99.69%

99.69

Related Targets	Integrase Antibiotics Anti-infection Fungal Antiviral COVID-19 Parasite Reverse Transcriptase HIV HCV Protease
Other Bacterial Inhibitors	BTZ043 Racemate Teicoplanin Pefloxacin Mesylate Ceftiofur Solithromycin 6-Methoxydihydrosanguinarine Proanthocyanidins Flagelin 22 Taurolidine Skatole

Solubility

In vitro
Batch:

DMSO : 73 mg/mL (199.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	3.65mg/ml (9.99mM)	Taking the 1 mL working solution as an example, add 50 μL of 73 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.52mg/ml (1.42mM)	Taking the 1 mL working solution as an example, add 50 μL of 10.4 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

%

% Tween 80

% ddH₂O

% DMSO

+

%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	365.4	Formula	C₁₆H₁₉N₃O₅S	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	26787-78-0	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	Amoxycillin			SMILES	CC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=C(C=C3)O)N)C(=O)O)C

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

In vitro

Amoxicillin treated cells secrete high amounts of interleukin-5 and mostly lower or no amounts of tumor necrosis factor alpha, interleukin-4, and interferon-gamma. This compound-specific T cell clones fails to show drug-specific cytotoxicity, but killed target cells in the presence of concanavalin A, indicating a principal ability to be cytolytic. It releases faster in pH 1.0 hydrochloric acid (HCl) than in pH 7.8 phosphate buffer. The chemical would be degraded to some extent in a pH 1.0 HCl medium at 37 degrees C, which indicated that it is not stable in an acidic surrounding. It inhibits 4 of 15 isolates at 8 mg/mL or less but is not bactericidal against any of the isolates at that concentration. This compound in combination with clavulanic acid is bactericidal for 14 of 15 isolates tested at an amoxicillin concentration of 4 mg/mL or less and a clavulanic acid concentration of 2 mg/mL or less. It inhibits 50% of isolates tested decreased from 0.5 mg/mL (range, 0.25 to 1 mg/mL) to 0.06 mg/mL (range, 0.01 to 0.25 mg/mL) in the presence of only 4 mg of cefotaxime per mL.

References

[1] https://pubmed.ncbi.nlm.nih.gov/10998137/
[2] https://pubmed.ncbi.nlm.nih.gov/15653140/
[3] https://pubmed.ncbi.nlm.nih.gov/6416162/

[4] https://pubmed.ncbi.nlm.nih.gov/8540703/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2025-06-13)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT06461429	NOT_YET_RECRUITING	Preterm Birth	University of Melbourne	2025-11-01
NCT07730814	NOT_YET_RECRUITING	Acute Otitis Media (AOM)	Nader Shaikh	2026-10-01	PHASE4
NCT07732699	NOT_YET_RECRUITING	ACUTE SINUSITIS; Sinusitis	Nader Shaikh	2026-10-01	PHASE4
NCT07457385	NOT_YET_RECRUITING	Syphilis, Congenital	University of Alabama at Birmingham	2026-11-01	PHASE4
NCT07485010	NOT_YET_RECRUITING	Mycobacterium Abscessus Pulmonary Disease; Mycobacterium Abscessus Infection; Non-Tuberculous Mycobacterial (NTM) Infections; Non-Tuberculous Mycobacteria Pulmonary Disease	The University of Queensland	2027-04	PHASE2
NCT07576959	RECRUITING	HELICOBACTER PYLORI INFECTIONS	National Taiwan University Hospital	2026-04-08	PHASE3

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Amoxicillin Bacterial chemical

Chemical Structure

Molecular Weight: 365.4