AOA hemihydrochloride

Catalog No.S4989 Synonyms: Carboxymethoxylamine hemihydrochloride, AOAA hemihydrochloride, AOA hemihydrochloride

AOA hemihydrochloride Chemical Structure

Molecular Weight(MW): 109.3

Aminooxyacetic acid is an inhibitor of aminobutyrate aminotransferase involved in amino acid and polyamine metabolism.

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Biological Activity

Description Aminooxyacetic acid is an inhibitor of aminobutyrate aminotransferase involved in amino acid and polyamine metabolism.
Targets
GABA-T [1]
()
Malate-aspartate shuttle [1]
()
In vitro

Aminooxyacetic acid (AOAA) is a malate-aspartate shuttle inhibitor, leading to decreased intracellular ATP levels and altering cell cycle and increasing apoptosis and necrosis of C6 glioma cells, without affecting the survival of primary astrocyte cultures. AOAA also decreases the glycolytic rate and the levels of extracellular lactate and pyruvate, without affecting the mitochondrial membrane potential of C6 cells. Aminooxyacetic acid can selectively inhibit the proliferation of breast cancer cells[1].

In vivo Aminooxyacetic acid suppresses the growth of breast adenocarcinoma in athymic mice[1]. AOAA is much less toxic in rats than in mice[2].

Protocol

Cell Research:

[1]

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  • Cell lines: C6 glioma cells
  • Concentrations: 0.1, 0.25, 0.5, 1, 5 mM
  • Incubation Time: 24 h
  • Method:

    C6 glioma cells are plated into 24-well or 12-well cell culture plates at the initial density of 1 × 106 cells/mL in Dulbecco's Modified Eagle's Medium containing 4500 mg/L D-glucose, 584 mg/L L-glutamine, and 1% penicillin and streptomycin, supplemented with 10% fetal bovine serum. The cells are maintained in a 5% CO2 incubator at 37℃. Cell survival is assessed 24 h after AOAA treatment by intracellular LDH assay.


    (Only for Reference)
Animal Research:

[2]

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  • Animal Models: female Wistar rats
  • Formulation: water
  • Dosages: 15 to 100 mg/kg
  • Administration: i.p. or s.c.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 21 mg/mL (192.13 mM)
Water 21 mg/mL (192.13 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 109.3
Formula

C2H5NO3.1/2HCl

CAS No. 2921-14-4
Storage powder
in solvent
Synonyms Carboxymethoxylamine hemihydrochloride, AOAA hemihydrochloride, AOA hemihydrochloride

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Transferase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID