Catalog No.S4989 Synonyms: Carboxymethoxylamine hemihydrochloride, AOAA hemihydrochloride, AOA hemihydrochloride
Molecular Weight(MW): 109.3
Aminooxyacetic acid is an inhibitor of aminobutyrate aminotransferase involved in amino acid and polyamine metabolism.
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|Description||Aminooxyacetic acid is an inhibitor of aminobutyrate aminotransferase involved in amino acid and polyamine metabolism.|
Aminooxyacetic acid (AOAA) is a malate-aspartate shuttle inhibitor, leading to decreased intracellular ATP levels and altering cell cycle and increasing apoptosis and necrosis of C6 glioma cells, without affecting the survival of primary astrocyte cultures. AOAA also decreases the glycolytic rate and the levels of extracellular lactate and pyruvate, without affecting the mitochondrial membrane potential of C6 cells. Aminooxyacetic acid can selectively inhibit the proliferation of breast cancer cells.
|In vivo||Aminooxyacetic acid suppresses the growth of breast adenocarcinoma in athymic mice. AOAA is much less toxic in rats than in mice.|
|In vitro||DMSO||21 mg/mL (192.13 mM)|
|Water||21 mg/mL (192.13 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Synonyms||Carboxymethoxylamine hemihydrochloride, AOAA hemihydrochloride, AOA hemihydrochloride|
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