All Products

Catalog No. Product Name Information
S8337 1400W 2HCl 1400W (N-(3-(Aminomethyl)benzyl)acetamidine) is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase(iNOS).
S0409 5WKS 5WKS (ZINC97756584) is an active biochemical.
E0382 W-84 Dibromide

W-84 Dibromide is a potent allosteric modulator of M2-cholinoceptors, which retards [3H]N-methylscopolamine dissociation.

S0195 Walrycin B Walrycin B is an antibacterial compound and a potent inhibitor of WalR targeting the WalR response regulator.
S9485 Waltonitone Waltonitone, an ursane-type pentacyclic triterpene extracted from Gentiana waltonii Burkill, exerts anti-tumor effect.
S4545 Warfarin Warfarin (Athrombine K, Coumadin, Coumafene, WARF 42, Zoocoumarin) is one of the most widely used anticoagulant drugs worldwide, used in the prevention of thrombosis and thromboembolism, the formation of blood clots in the blood vessels and their migration elsewhere in the body.
A5339 WASF2 Rabbit Recombinant mAb WASF2 Rabbit Recombinant mAb detects endogenous level of total WASF2.
A5400 WASL Rabbit Recombinant mAb WASL Rabbit Recombinant mAb detects endogenous level of total WASL.
S2663 WAY-100635 Maleate WAY-100635 Maleate is a potent and selective 5-HT receptor antagonist with IC50 of 0.95 nM.
S3458 WAY-169916 WAY-169916 is a pathway-selective inhibitor of estrogen receptor (ER) that acts by inhibiting NF-kB transcriptional activity.
S0143 WAY-200070 WAY-200070 is an agonist selective estrogen receptor β (ERRβ) with IC50 of 2.3 nM.
S5892 WAY-213613 WAY-213613 is a potent, selective nonsubstrate reuptake inhibitor of GLT-1 and EAAT2 with IC50 of 85 nM for EAAT2.
S9828 WAY-262611 WAY-262611 (BML-WN110, Compound 5) is a beta-catenin (β-Catenin) agonist that increases bone formation rate with EC50 of 0.63 μM in TCF-Luciferase assay. WAY-262611 is also an inhibitor of dickkopf 1 (DKK1).
S5815 WAY-316606 WAY-316606, a specific antagonist of SFRP1, functions as an activator of canonical Wnt/β-catenin signalling in the human hair bulb.
A5486 WDR5 Rabbit Recombinant mAb WDR5 Rabbit Recombinant mAb detects endogenous level of total WDR5.
S2184 WDR5-0103 WDR5-0103 (WD-Repeat Protein 5-0103) is a small-molecule antagonist of WDR5 (WD40 repeat protein 5) with Kd of 450 nM.
S9042 Wedelolactone Wedelolactone, a medicinal plant-derived natural compound, is an inhibitor of IKK that is critical for activation of NF-κB by mediating phosphorylation and degradation of IκBα. Wedelolactone is also an inhibitor of caspase-11.
S7100 WEHI-539 HCl WEHI-539 HCl (WEHI-539 hydrochloride) has high affinity (IC50=1.1 nM) and selectivity for BCL-XL and potently kills cells by selectively antagonizing its prosurvival activity. It has more than a 400-fold higher affinity for BCL-XL versus other prosurvival BCL-2 family members.
S0393 WEHL-03 WEHL-03 is an active compound.
S0394 WEHL-04 WEHL-04 (7-Bromo-1,2,3,4-tetrahydroquinoline) is an active compound.
S7565 WH-4-023 WH-4-023 (KIN001-112, KIN112, Dual LCK/SRC inhibitor) is a potent and orally active Lck/Src inhibitor with IC50s of 2 nM and 6 nM in cell-free assays, respectively. Exhibits >300-fold selectivity against p38α and KDR. Also potently inhibits SIK (IC50 values are 10, 22 and 60 nM for SIK 1, 2 and 3 respectively) and displays selectivity over a range of closely related kinases.
E0383 WH-4-025

WH-4-025 is a potent inhibitor of Salt-inducible kinase (SIK).

S2867 WHI-P154 WHI-P154 is a potent JAK3 inhibitor with IC50 of 1.8 μM, no activity against JAK1 or JAK2, also inhibits EGFR, Src, Abl, VEGFR and MAPK, prevents Stat3, but not Stat5 phosphorylation.
S6520 WHI-P180 WHI-P180 is a multi-kinase inhibitor with IC50 values of 4.5 and 66 nM for the human proto-oncogene RET (c-RET) and kinase insert domain receptor (KDR), respectively.
S6521 WHI-P258 WHI-P258 is an inhibitor of JAK3 with Ki value of 72 μM.
S5904 WHI-P97 WHI-P97 is a potent inhibitor of JAK-3 with an estimated Ki value of 0.09 μM in modeling studies and a measured IC50 value of 2.5 μM in EGFR kinase inhibition assays.
S7490 WIKI4 WIKI4 is a novel Tankyrase inhibitor with IC50 of 15 nM for TNKS2, and leads to inhibition of Wnt/beta-catenin signaling.
S0973 Wilforgine Wilforgine, one of the major bioactive sesquiterpene alkaloids in Tripterygium wilfordii Hook. F., induces microstructural and ultrastructural changes in the muscles of M. separata larvae, and the sites of action are proposed to be calcium receptors or channels in the muscular system.
S0921 Wilforine Wilforine (WR), a sesquiterpene pyridine alkaloid found in T. wilfordii plants, significantly inhibits the efflux activity of P-glycoprotein (P-gp).
S6428 Wilforlide A Wilforlide A is an active compound in Tripterygium wilfordii Hook F (TW) which is a traditional Chinese medicine for treatment of autoimmune diseases.
A5327 Wilms Tumor Protein Rabbit Recombinant mAb Wilms Tumor Protein Rabbit Recombinant mAb detects endogenous level of total wilms tumor protein.
S8017 WIN 55, 212-2 mesylate WIN 55,212-2 Mesylate ((R)-(+)-WIN 55212) is a potent cannabinoid (CB) receptor agonist with Ki of 3.3 nM and 62.3 nM for human recombinant CB2 and CB1, respectively. WIN 55,212-2 Mesylate regulates Glutamate transmission.
S8587 Withaferin A Withaferin A (WA, WFA) potently inhibits NF-κB activation by preventing the tumor necrosis factor-induced activation of IκB kinase β via a thioalkylation-sensitive redox mechanism. Withaferin A binds to the intermediate filament (IF) protein, vimentin with antitumor and antiangiogenesis activity. Withaferin A is a steroidal lactone isolated from Withania somnifera.
S6353 Withanolide A Withanolide A is a natural compound isolated from the indian herbal drug Ashwagandha (root of Withania somnifera). Withanolide A can regenerate neurites and reconstruct synapses in severely damaged neurons.
S2976 WJ460 WJ460 is a potent inhibitor of myoferlin (MYOF) that interacts directly with MYOF and exerts anti-metastatic activity in the nanomolar range in breast cancer cells.
S9805 WM-3835 WM-3835 is a novel and high-specific small molecule Lysine Acetyltransferase 7 (KAT7, MYST2, HBO1) inhibitor, able to potently suppressed OS cell proliferation and migration, and leads to apoptosis activation.
S6655 WM-8014 WM-8014 is a highly potent inhibitor of histone acetyltransferase KAT6A with an IC50 of 8 nM.
S0015 WNK-IN-11 WNK-IN-11 is a potent, selective, and orally acitve allosteric inhibitor of With-No-Lysine (WNK) kinase with IC50 of 4 nM for WNK1 enzyme.
S8358 WNK463 WNK463 is a pan-WNK-kinase inhibitor. It potently inhibits the in vitro kinase activity of all four WNK family members (WNK1, WNK2, WNK3, and WNK4).
S8178 Wnt agonist 1 Wnt agonist 1 (BML-284 HCL, AMBMP HCL) is a cell permeable Wnt signaling pathway activator, which induces β-catenin- and TCF-dependent transcriptional activity with EC50 of 0.7 μM.
S7037 Wnt-C59 (C59) Wnt-C59 (C59) is a PORCN inhibitor for Wnt3A-mediated activation of a multimerized TCF-binding site driving luciferase with IC50 of 74 pM in HEK293 cells.
S4743 Wogonin Wogonin (Vogonin), a natural and biologically-active flavonoid found in plants, is an inhibitor of CDK9 and does not inhibit CDK2, CDK4 and CDK6 at doses that inhibit CDK9 activity; Also inhibits N-acetyltransferase.
S9115 Wogonoside Wogonoside (Oroxindin, Wogonin 7-O-glucuronide, Glychionide B), the main flavonoid component derived from the root of Scutellaria baicalensis Georgi, displays anti-inflammatory, anti-angiogenic, and anticancer chemotherapeutic activities.
S2758 Wortmannin (KY 12420) Wortmannin (KY 12420, SL-2052, BRN 0067676, NSC 627609) is the first described PI3K inhibitor with IC50 of 3 nM in a cell-free assay, with little selectivity within the PI3K family. Wortmannin blocks autophagosome formation and potently inhibits DNA-PK/ATM with IC50 of 16 nM and 150 nM in cell-free assays. Wortmannin also inhibits PLK1 activity.
S2796 WP1066 WP1066 is a novel inhibitor of JAK2 and STAT3 with IC50 of 2.30 μM and 2.43 μM in HEL cells; shows activity to JAK2, STAT3, STAT5, and ERK1/2 not JAK1 and JAK3. WP1066 induces apoptosis. Phase 1.
E0388 WQ 1

WQ 1 is a highly potent and selective sigma 1 (σ1) receptor antagonist with pKi of 10.28.

S9818 WRW4 WRW4 is a specific formyl peptide receptor-like 1 (FPRL1) antagonist that inhibits WKYMVm binding to FPRL1 with IC50 of 0.23 μM. WRW4 is a selective antagonist of formyl peptide receptor type 2 (FPR2)/Lipoxin A4 receptor (ALX).
S2963 WS-12 WS-12 is a potent TRPM8 agonist with an EC50 of 39 nM.
S7764 WST-8 WST-8 is a water-soluble tetrazolium salt used for assessing cell metabolic activity that produces corresponding formazan dye that absorbs at 460 nm. WST-8 is typically used as a cell viability indicator in cell proliferation assays.
S8495 WT161 WT161 is a potent, selective, and bioavailable HDAC6 inhibitor with IC50 values of 0.4 nM, 8.35 nM and 15.4 nM for HDAC6, HDAC1 and HDAC2, respectively; shown to have >100-fold selectivity over other HDACs. WT161 induces apoptosis.
S3182 WUN-29654

WUN-29654 (CRBN modulator-1, compound 10) is a Thalidomide analog and a CRBN modulator with IC50 of 3.5 μM and Ki of 0.98 μM for CRBN binding.

S0967 Wushanicaritin Wushanicaritin exhibits antioxidant activity with IC50 of 35.3 μM in DPPH radical scavenging activity tests. Wushanicaritin has antitumor effects and anti-inflammatory property. Wushanicaritin is isolated from the traditional Chinese medicine Epimedium plants.
S5896 WWL-154 WWL-154 is an inhibitor of serine hydrolase (SH) and fatty acid amide hydrolase FAAH-4.
S3487 WWL229 WWL229 is a selective inhibitor of Ces3 that acts by inhibiting recombinant Ces3 and recapitulating the effects of WWL113 in adipocytes.
S8029 WY-14643 (Pirinixic Acid) WY-14643 (Pirinixic Acid, NSC 310038) is a potent and selective PPARα activator with an EC50 of 1.5 μM.
S0317 WYC-209 WYC-209 is a synthetic retinoid and an agonist of retinoic acid receptor (RAR). WYC-209 induces apoptosis primarily via the caspase 3 pathway with IC50 of 0.19 μM for inmalignant murine melanoma TRCs. WYC-209 has long-term effects with little toxicity.
S2661 WYE-125132 (WYE-132) WYE-125132 (WYE-132) is a highly potent, ATP-competitive mTOR inhibitor with IC50 of 0.19 nM; highly selective for mTOR versus PI3Ks or PI3K-related kinases hSMG1 and ATR.